C1orf61

Functionⁱ

May play a role in FOS signaling pathways involved in development and remodeling of neurons. Promotes transcription of the FOS promoter.1 Publication

GO - Biological processⁱ

positive regulation of transcription by RNA polymerase II
Source: UniProtKB
Inferred from direct assayⁱ
- 10995546

View the complete GO annotation on QuickGO ...

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Protein CROC-4 Alternative name(s): Contingent replication of cDNA 4
Gene namesⁱ	Name:C1orf61 Synonyms:CROC4
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 1

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000125462.16
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:30780 C1orf61
neXtProtⁱ	NX_Q13536

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	10485
Open Targets More...OpenTargetsⁱ	ENSG00000125462
PharmGKBⁱ	PA142672511

Polymorphism and mutation databases

BioMutaⁱ	C1orf61

BioMutaⁱ

C1orf61

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000333952	1 – 156	Protein CROC-4Add BLAST		156

Proteomic databases

PaxDbⁱ	Q13536
PRIDEⁱ	Q13536
ProteomicsDBⁱ	59524

Expressionⁱ

Tissue specificityⁱ

Expressed throughout the brain in the thalamus, subthalamic nucleus, corpus callosum, hippocampus, substantia nigra, caudate nucleus, and amygdala.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000125462
CleanExⁱ	HS_C1orf61
ExpressionAtlasⁱ	Q13536 baseline and differential
Genevisibleⁱ	Q13536 HS

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q13536
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Phylogenomic databases

eggNOGⁱ	ENOG410J4DY Eukaryota ENOG4111BGU LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000005493
HOGENOMⁱ	HOG000111975
InParanoidⁱ	Q13536
PhylomeDBⁱ	Q13536
TreeFamⁱ	TF342418

Sequenceⁱ

Sequence statusⁱ: Complete.

Q13536-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MFLTEDLITF NLRNFLLFQL WESSFSPGAG GFCTTLPPSF LRVDDRATSS 
        60         70         80         90        100
TTDSSRAPSS PRPPGSTSHC GISTRCTERC LCVLPLRTSQ VPDVMAPQHD 
       110        120        130        140        150
QEKFHDLAYS CLGKSFSMSN QDLYGYSTSS LALGLAWLSW ETKKKNVLHL 

VGLDSL

Length:156

Mass (Da):17,231

Last modified:November 1, 1996 - v1

Checksum:ⁱ939C3E7168FE35CE

GO

Sequence cautionⁱ

The sequence CAI12173 differs from that shown. Reason: Erroneous gene model prediction.Curated

The sequence CAI12175 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U49857 mRNA Translation: AAA93029.1 AL139130 Genomic DNA Translation: CAI12172.1 AL139130 Genomic DNA Translation: CAI12173.1 Sequence problems. AL139130 Genomic DNA Translation: CAI12175.1 Sequence problems. CH471121 Genomic DNA Translation: EAW52956.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS1142.1
NCBI Reference Sequences More...RefSeqⁱ	NP_006356.1, NM_006365.2 XP_011507372.1, XM_011509070.1 XP_011507373.1, XM_011509071.2 XP_011507374.1, XM_011509072.1 XP_016855551.1, XM_017000062.1 XP_016855552.1, XM_017000063.1
UniGeneⁱ	Hs.380027

Genome annotation databases

Ensemblⁱ	ENST00000368243; ENSP00000357226; ENSG00000125462 ENST00000615748; ENSP00000479346; ENSG00000125462
GeneIDⁱ	10485
KEGGⁱ	hsa:10485
UCSC genome browser More...UCSCⁱ	uc001fou.2 human

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length
Q13536	C1orf61 isoform 13		PONAB		156
C1orf61 isoform 13		PANTR		155
Chromosome 1 open reading frame 61		PANPA		155
Chromosome 1 open reading frame 61		COLAP		155
Uncharacterized protein		CERAT		155
+9

Protein	Similar proteins		Species	Score	Length
Q13536	C1orf61 isoform 13		PONAB		156
Chromosome 1 open reading frame 61		COLAP		155
C1orf61 isoform 13		PANTR		155
Chromosome 1 open reading frame 61		PANPA		155
Uncharacterized protein		MANLE		155
+19

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U49857 mRNA Translation: AAA93029.1 AL139130 Genomic DNA Translation: CAI12172.1 AL139130 Genomic DNA Translation: CAI12173.1 Sequence problems. AL139130 Genomic DNA Translation: CAI12175.1 Sequence problems. CH471121 Genomic DNA Translation: EAW52956.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS1142.1
NCBI Reference Sequences More...RefSeqⁱ	NP_006356.1, NM_006365.2 XP_011507372.1, XM_011509070.1 XP_011507373.1, XM_011509071.2 XP_011507374.1, XM_011509072.1 XP_016855551.1, XM_017000062.1 XP_016855552.1, XM_017000063.1
UniGeneⁱ	Hs.380027

3D structure databases

ProteinModelPortalⁱ	Q13536
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Polymorphism and mutation databases

BioMutaⁱ	C1orf61

BioMutaⁱ

C1orf61

Proteomic databases

PaxDbⁱ	Q13536
PRIDEⁱ	Q13536
ProteomicsDBⁱ	59524

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	10485
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000368243; ENSP00000357226; ENSG00000125462 ENST00000615748; ENSP00000479346; ENSG00000125462
GeneIDⁱ	10485
KEGGⁱ	hsa:10485
UCSC genome browser More...UCSCⁱ	uc001fou.2 human

Organism-specific databases

CTDⁱ	10485
DisGeNET More...DisGeNETⁱ	10485
EuPathDBⁱ	HostDB:ENSG00000125462.16
GeneCardsⁱ	C1orf61
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:30780 C1orf61
neXtProtⁱ	NX_Q13536
Open Targets More...OpenTargetsⁱ	ENSG00000125462
PharmGKBⁱ	PA142672511
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410J4DY Eukaryota ENOG4111BGU LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000005493
HOGENOMⁱ	HOG000111975
InParanoidⁱ	Q13536
PhylomeDBⁱ	Q13536
TreeFamⁱ	TF342418

Miscellaneous databases

ChiTaRSⁱ	C1orf61 human
GenomeRNAiⁱ	10485
Protein Ontology More...PROⁱ	PR:Q13536

Gene expression databases

Bgeeⁱ	ENSG00000125462
CleanExⁱ	HS_C1orf61
ExpressionAtlasⁱ	Q13536 baseline and differential
Genevisibleⁱ	Q13536 HS

Family and domain databases

ProtoNetⁱ	Search...

ProtoNetⁱ

Search...

Entry informationⁱ

Entry nameⁱ	CROC4_HUMAN
Accessionⁱ	Q13536Primary (citable) accession number: Q13536 Secondary accession number(s): B1ALL5, B1ALL8
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	May 20, 2008
	Last sequence update:	November 1, 1996
	Last modified:	June 20, 2018
	This is version 101 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q13536 (CROC4_HUMAN)

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Protein CROC-4

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Phylogenomic databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence cautionⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ