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UniProtKB - Q13535 (ATR_HUMAN)

Protein

Serine/threonine-protein kinase ATR

Gene

ATR

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates BRCA1, CHEK1, MCM2, RAD17, RPA2, SMC1 and p53/TP53, which collectively inhibit DNA replication and mitosis and promote DNA repair, recombination and apoptosis. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at sites of DNA damage, thereby regulating DNA damage response mechanism. Required for FANCD2 ubiquitination. Critical for maintenance of fragile site stability and efficient regulation of centrosome duplication.24 Publications

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Cofactori

Mn2+1 Publication

Activity regulationi

Serine/threonine-protein kinase activity is directly stimulated by TOPBP1 (PubMed:16530042). ATR kinase activity is also directly activated by ETAA1, independently of TOPBP1 (PubMed:27723720, PubMed:27723717). Activated by DNA and inhibited by BCR-ABL oncogene (PubMed:10597277). Slightly activated by ATRIP (PubMed:14729973). Inhibited by caffeine, wortmannin and LY294002 (PubMed:9766667).6 Publications

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

Keywordsi

Molecular functionDNA-binding, Kinase, Serine/threonine-protein kinase, Transferase
Biological processDNA damage, DNA repair
LigandATP-binding, Manganese, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-HSA-1221632 Meiotic synapsis
R-HSA-176187 Activation of ATR in response to replication stress
R-HSA-3371453 Regulation of HSF1-mediated heat shock response
R-HSA-5685938 HDR through Single Strand Annealing (SSA)
R-HSA-5693607 Processing of DNA double-strand break ends
R-HSA-5693616 Presynaptic phase of homologous DNA pairing and strand exchange
R-HSA-6783310 Fanconi Anemia Pathway
R-HSA-6796648 TP53 Regulates Transcription of DNA Repair Genes
R-HSA-6804756 Regulation of TP53 Activity through Phosphorylation
R-HSA-69473 G2/M DNA damage checkpoint
SignaLinkiQ13535
SIGNORiQ13535

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase ATR (EC:2.7.11.1)
Alternative name(s):
Ataxia telangiectasia and Rad3-related protein
FRAP-related protein 1
Gene namesi
Name:ATR
Synonyms:FRP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000175054.14
HGNCiHGNC:882 ATR
MIMi601215 gene
neXtProtiNX_Q13535

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Nucleus

Pathology & Biotechi

Involvement in diseasei

Seckel syndrome 1 (SCKL1)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA rare autosomal recessive disorder characterized by proportionate dwarfism of prenatal onset associated with low birth weight, growth retardation, severe microcephaly with a bird-headed like appearance, and mental retardation.
See also OMIM:210600
Cutaneous telangiectasia and cancer syndrome, familial (FCTCS)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disease characterized by cutaneous telangiectases in infancy with patchy alopecia over areas of affected skin, thinning of the lateral eyebrows, and mild dental and nail anomalies. Affected individuals are at increased risk of developing oropharyngeal cancer, and other malignancies have been reported as well.
See also OMIM:614564
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0679192144Q → R in FCTCS. 1 PublicationCorresponds to variant dbSNP:rs387906797EnsemblClinVar.1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi2327K → R: Abolishes kinase activity. 3 Publications1
Mutagenesisi2475D → A: Abolishes kinase activity; increases sensitivity to IR and impairs translocation to nuclear foci upon DNA damage. 3 Publications1
Mutagenesisi2494D → E: Abolishes kinase activity; reduces cell viability, augments sensitivity to IR and UV. 2 Publications1

Keywords - Diseasei

Disease mutation, Dwarfism, Mental retardation

Organism-specific databases

DisGeNETi545
GeneReviewsiATR
MalaCardsiATR
MIMi210600 phenotype
614564 phenotype
OpenTargetsiENSG00000175054
Orphaneti313846 Familial cutaneous telangiectasia and oropharyngeal cancer predisposition syndrome
808 Seckel syndrome
PharmGKBiPA74

Chemistry databases

ChEMBLiCHEMBL5024
GuidetoPHARMACOLOGYi1935

Polymorphism and mutation databases

BioMutaiATR
DMDMi62286460

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000888441 – 2644Serine/threonine-protein kinase ATRAdd BLAST2644

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei428PhosphoserineCombined sources1 Publication1
Modified residuei435PhosphoserineCombined sources1
Modified residuei436PhosphoserineCombined sources1
Modified residuei1989PhosphothreonineCombined sources1

Post-translational modificationi

Phosphorylated; autophosphorylates in vitro.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ13535
MaxQBiQ13535
PaxDbiQ13535
PeptideAtlasiQ13535
PRIDEiQ13535
ProteomicsDBi59521
59522 [Q13535-2]
59523 [Q13535-3]

PTM databases

CarbonylDBiQ13535
iPTMnetiQ13535
PhosphoSitePlusiQ13535

Expressioni

Tissue specificityi

Ubiquitous, with highest expression in testis. Isoform 2 is found in pancreas, placenta and liver but not in heart, testis and ovary.3 Publications

Gene expression databases

BgeeiENSG00000175054 Expressed in 225 organ(s), highest expression level in endometrium
CleanExiHS_ATR
ExpressionAtlasiQ13535 baseline and differential
GenevisibleiQ13535 HS

Organism-specific databases

HPAiHPA054320

Interactioni

Subunit structurei

Interacts with ATRIP; forming a heterodimer with ATRIP (PubMed:11721054). Binds to DNA, and to UV-damaged DNA with higher affinity. Interacts with RAD17, MSH2 and HDAC2. Present in a complex containing ATRIP and RPA-coated single-stranded DNA. Present in a complex containing CHD4 and HDAC2. Interacts with BCR-ABL after genotoxic stress. Interacts with EEF1E1. This interaction is enhanced by UV irradiation. Interacts with CLSPN and CEP164. Interacts with TELO2 and TTI1.By similarity15 Publications

Binary interactionsi

Protein-protein interaction databases

BioGridi107027, 128 interactors
ComplexPortaliCPX-3622 ATR-ATRIP DNA damage-sensing kinase complex
CORUMiQ13535
DIPiDIP-35308N
IntActiQ13535, 25 interactors
MINTiQ13535
STRINGi9606.ENSP00000343741

Chemistry databases

BindingDBiQ13535

Structurei

3D structure databases

ProteinModelPortaliQ13535
SMRiQ13535
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati799 – 835HEAT 1Add BLAST37
Repeati1329 – 1365HEAT 2Add BLAST37
Domaini1640 – 2185FATPROSITE-ProRule annotationAdd BLAST546
Domaini2322 – 2567PI3K/PI4KPROSITE-ProRule annotationAdd BLAST246
Domaini2612 – 2644FATCPROSITE-ProRule annotationAdd BLAST33

Sequence similaritiesi

Belongs to the PI3/PI4-kinase family. ATM subfamily.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0890 Eukaryota
COG5032 LUCA
GeneTreeiENSGT00930000150922
HOGENOMiHOG000034221
HOVERGENiHBG050619
InParanoidiQ13535
KOiK06640
OMAiWMLLPHF
OrthoDBiEOG091G013Q
PhylomeDBiQ13535
TreeFamiTF101183

Family and domain databases

Gene3Di1.10.1070.11, 1 hit
1.25.10.10, 2 hits
1.25.40.10, 1 hit
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR003152 FATC_dom
IPR021133 HEAT_type_2
IPR011009 Kinase-like_dom_sf
IPR000403 PI3/4_kinase_cat_dom
IPR036940 PI3/4_kinase_cat_sf
IPR018936 PI3/4_kinase_CS
IPR003151 PIK-rel_kinase_FAT
IPR014009 PIK_FAT
IPR011990 TPR-like_helical_dom_sf
IPR012993 UME
PfamiView protein in Pfam
PF02259 FAT, 1 hit
PF02260 FATC, 1 hit
PF00454 PI3_PI4_kinase, 1 hit
PF08064 UME, 1 hit
SMARTiView protein in SMART
SM01343 FATC, 1 hit
SM00146 PI3Kc, 1 hit
SM00802 UME, 1 hit
SUPFAMiSSF48371 SSF48371, 2 hits
SSF48452 SSF48452, 1 hit
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS51189 FAT, 1 hit
PS51190 FATC, 1 hit
PS50077 HEAT_REPEAT, 1 hit
PS00916 PI3_4_KINASE_2, 1 hit
PS50290 PI3_4_KINASE_3, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q13535-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGEHGLELAS MIPALRELGS ATPEEYNTVV QKPRQILCQF IDRILTDVNV 
        60         70         80         90        100
VAVELVKKTD SQPTSVMLLD FIQHIMKSSP LMFVNVSGSH EAKGSCIEFS 
       110        120        130        140        150
NWIITRLLRI AATPSCHLLH KKICEVICSL LFLFKSKSPA IFGVLTKELL 
       160        170        180        190        200
QLFEDLVYLH RRNVMGHAVE WPVVMSRFLS QLDEHMGYLQ SAPLQLMSMQ 
       210        220        230        240        250
NLEFIEVTLL MVLTRIIAIV FFRRQELLLW QIGCVLLEYG SPKIKSLAIS 
       260        270        280        290        300
FLTELFQLGG LPAQPASTFF SSFLELLKHL VEMDTDQLKL YEEPLSKLIK 
       310        320        330        340        350
TLFPFEAEAY RNIEPVYLNM LLEKLCVMFE DGVLMRLKSD LLKAALCHLL 
       360        370        380        390        400
QYFLKFVPAG YESALQVRKV YVRNICKALL DVLGIEVDAE YLLGPLYAAL 
       410        420        430        440        450
KMESMEIIEE IQCQTQQENL SSNSDGISPK RRRLSSSLNP SKRAPKQTEE 
       460        470        480        490        500
IKHVDMNQKS ILWSALKQKA ESLQISLEYS GLKNPVIEML EGIAVVLQLT 
       510        520        530        540        550
ALCTVHCSHQ NMNCRTFKDC QHKSKKKPSV VITWMSLDFY TKVLKSCRSL 
       560        570        580        590        600
LESVQKLDLE ATIDKVVKIY DALIYMQVNS SFEDHILEDL CGMLSLPWIY 
       610        620        630        640        650
SHSDDGCLKL TTFAANLLTL SCRISDSYSP QAQSRCVFLL TLFPRRIFLE 
       660        670        680        690        700
WRTAVYNWAL QSSHEVIRAS CVSGFFILLQ QQNSCNRVPK ILIDKVKDDS 
       710        720        730        740        750
DIVKKEFASI LGQLVCTLHG MFYLTSSLTE PFSEHGHVDL FCRNLKATSQ 
       760        770        780        790        800
HECSSSQLKA SVCKPFLFLL KKKIPSPVKL AFIDNLHHLC KHLDFREDET 
       810        820        830        840        850
DVKAVLGTLL NLMEDPDKDV RVAFSGNIKH ILESLDSEDG FIKELFVLRM 
       860        870        880        890        900
KEAYTHAQIS RNNELKDTLI LTTGDIGRAA KGDLVPFALL HLLHCLLSKS 
       910        920        930        940        950
ASVSGAAYTE IRALVAAKSV KLQSFFSQYK KPICQFLVES LHSSQMTALP 
       960        970        980        990       1000
NTPCQNADVR KQDVAHQREM ALNTLSEIAN VFDFPDLNRF LTRTLQVLLP 
      1010       1020       1030       1040       1050
DLAAKASPAA SALIRTLGKQ LNVNRREILI NNFKYIFSHL VCSCSKDELE 
      1060       1070       1080       1090       1100
RALHYLKNET EIELGSLLRQ DFQGLHNELL LRIGEHYQQV FNGLSILASF 
      1110       1120       1130       1140       1150
ASSDDPYQGP RDIISPELMA DYLQPKLLGI LAFFNMQLLS SSVGIEDKKM 
      1160       1170       1180       1190       1200
ALNSLMSLMK LMGPKHVSSV RVKMMTTLRT GLRFKDDFPE LCCRAWDCFV 
      1210       1220       1230       1240       1250
RCLDHACLGS LLSHVIVALL PLIHIQPKET AAIFHYLIIE NRDAVQDFLH 
      1260       1270       1280       1290       1300
EIYFLPDHPE LKKIKAVLQE YRKETSESTD LQTTLQLSMK AIQHENVDVR 
      1310       1320       1330       1340       1350
IHALTSLKET LYKNQEKLIK YATDSETVEP IISQLVTVLL KGCQDANSQA 
      1360       1370       1380       1390       1400
RLLCGECLGE LGAIDPGRLD FSTTETQGKD FTFVTGVEDS SFAYGLLMEL 
      1410       1420       1430       1440       1450
TRAYLAYADN SRAQDSAAYA IQELLSIYDC REMETNGPGH QLWRRFPEHV 
      1460       1470       1480       1490       1500
REILEPHLNT RYKSSQKSTD WSGVKKPIYL SKLGSNFAEW SASWAGYLIT 
      1510       1520       1530       1540       1550
KVRHDLASKI FTCCSIMMKH DFKVTIYLLP HILVYVLLGC NQEDQQEVYA 
      1560       1570       1580       1590       1600
EIMAVLKHDD QHTINTQDIA SDLCQLSTQT VFSMLDHLTQ WARHKFQALK 
      1610       1620       1630       1640       1650
AEKCPHSKSN RNKVDSMVST VDYEDYQSVT RFLDLIPQDT LAVASFRSKA 
      1660       1670       1680       1690       1700
YTRAVMHFES FITEKKQNIQ EHLGFLQKLY AAMHEPDGVA GVSAIRKAEP 
      1710       1720       1730       1740       1750
SLKEQILEHE SLGLLRDATA CYDRAIQLEP DQIIHYHGVV KSMLGLGQLS 
      1760       1770       1780       1790       1800
TVITQVNGVH ANRSEWTDEL NTYRVEAAWK LSQWDLVENY LAADGKSTTW 
      1810       1820       1830       1840       1850
SVRLGQLLLS AKKRDITAFY DSLKLVRAEQ IVPLSAASFE RGSYQRGYEY 
      1860       1870       1880       1890       1900
IVRLHMLCEL EHSIKPLFQH SPGDSSQEDS LNWVARLEMT QNSYRAKEPI 
      1910       1920       1930       1940       1950
LALRRALLSL NKRPDYNEMV GECWLQSARV ARKAGHHQTA YNALLNAGES 
      1960       1970       1980       1990       2000
RLAELYVERA KWLWSKGDVH QALIVLQKGV ELCFPENETP PEGKNMLIHG 
      2010       2020       2030       2040       2050
RAMLLVGRFM EETANFESNA IMKKYKDVTA CLPEWEDGHF YLAKYYDKLM 
      2060       2070       2080       2090       2100
PMVTDNKMEK QGDLIRYIVL HFGRSLQYGN QFIYQSMPRM LTLWLDYGTK 
      2110       2120       2130       2140       2150
AYEWEKAGRS DRVQMRNDLG KINKVITEHT NYLAPYQFLT AFSQLISRIC 
      2160       2170       2180       2190       2200
HSHDEVFVVL MEIIAKVFLA YPQQAMWMMT AVSKSSYPMR VNRCKEILNK 
      2210       2220       2230       2240       2250
AIHMKKSLEK FVGDATRLTD KLLELCNKPV DGSSSTLSMS THFKMLKKLV 
      2260       2270       2280       2290       2300
EEATFSEILI PLQSVMIPTL PSILGTHANH ASHEPFPGHW AYIAGFDDMV 
      2310       2320       2330       2340       2350
EILASLQKPK KISLKGSDGK FYIMMCKPKD DLRKDCRLME FNSLINKCLR 
      2360       2370       2380       2390       2400
KDAESRRREL HIRTYAVIPL NDECGIIEWV NNTAGLRPIL TKLYKEKGVY 
      2410       2420       2430       2440       2450
MTGKELRQCM LPKSAALSEK LKVFREFLLP RHPPIFHEWF LRTFPDPTSW 
      2460       2470       2480       2490       2500
YSSRSAYCRS TAVMSMVGYI LGLGDRHGEN ILFDSLTGEC VHVDFNCLFN 
      2510       2520       2530       2540       2550
KGETFEVPEI VPFRLTHNMV NGMGPMGTEG LFRRACEVTM RLMRDQREPL 
      2560       2570       2580       2590       2600
MSVLKTFLHD PLVEWSKPVK GHSKAPLNET GEVVNEKAKT HVLDIEQRLQ 
      2610       2620       2630       2640 
GVIKTRNRVT GLPLSIEGHV HYLIQEATDE NLLCQMYLGW TPYM
Length:2,644
Mass (Da):301,367
Last modified:July 5, 2004 - v3
Checksum:i11BC22297FB9A802
GO
Isoform 2 (identifier: Q13535-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     450-450: E → D
     451-514: Missing.

Show »
Length:2,580
Mass (Da):294,219
Checksum:iA7C5CED46708FC16
GO
Isoform 3 (identifier: Q13535-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     2588-2610: AKTHVLDIEQRLQGVIKTRNRVT → VSRRYSLIWAVVLISTNELDMQL
     2611-2644: Missing.

Note: No experimental confirmation available.
Show »
Length:2,610
Mass (Da):297,479
Checksum:i44281024A65D73B1
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0Y9K2H0Y9K2_HUMAN
Serine/threonine-protein kinase ATR
ATR
457Annotation score:
H0Y8Y6H0Y8Y6_HUMAN
Serine/threonine-protein kinase ATR
ATR
80Annotation score:
D6RIG7D6RIG7_HUMAN
Serine/threonine-protein kinase ATR
ATR
309Annotation score:
D6RFJ6D6RFJ6_HUMAN
Serine/threonine-protein kinase ATR
ATR
100Annotation score:
H0Y8R8H0Y8R8_HUMAN
Serine/threonine-protein kinase ATR
ATR
39Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti92A → R in CAA70298 (PubMed:8978690).Curated1
Sequence conflicti92A → R in AAC50929 (PubMed:8978690).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04158464T → A1 PublicationCorresponds to variant dbSNP:rs35306038EnsemblClinVar.1
Natural variantiVAR_04158590H → Y1 PublicationCorresponds to variant dbSNP:rs28897763EnsemblClinVar.1
Natural variantiVAR_050532211M → T. Corresponds to variant dbSNP:rs2227928EnsemblClinVar.1
Natural variantiVAR_041586297K → N1 PublicationCorresponds to variant dbSNP:rs2229033EnsemblClinVar.1
Natural variantiVAR_041587316V → I1 PublicationCorresponds to variant dbSNP:rs28897764EnsemblClinVar.1
Natural variantiVAR_041588959V → M1 PublicationCorresponds to variant dbSNP:rs28910271EnsemblClinVar.1
Natural variantiVAR_0415891087Y → H1 PublicationCorresponds to variant dbSNP:rs34253059Ensembl.1
Natural variantiVAR_0415901213S → G1 PublicationCorresponds to variant dbSNP:rs34766606Ensembl.1
Natural variantiVAR_0415911488A → P in a lung squamous cell carcinoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_0505331526I → V. Corresponds to variant dbSNP:rs34124242EnsemblClinVar.1
Natural variantiVAR_0415921607S → N1 PublicationCorresponds to variant dbSNP:rs55724025EnsemblClinVar.1
Natural variantiVAR_0415931612N → S1 PublicationCorresponds to variant dbSNP:rs55894265EnsemblClinVar.1
Natural variantiVAR_0415942002A → G in a lung adenocarcinoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_0415952120G → A1 PublicationCorresponds to variant dbSNP:rs35134774Ensembl.1
Natural variantiVAR_0415962132Y → D1 PublicationCorresponds to variant dbSNP:rs28910273EnsemblClinVar.1
Natural variantiVAR_0679192144Q → R in FCTCS. 1 PublicationCorresponds to variant dbSNP:rs387906797EnsemblClinVar.1
Natural variantiVAR_0415972233S → I in a lung large cell carcinoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_0415982425R → Q1 PublicationCorresponds to variant dbSNP:rs2229032EnsemblClinVar.1
Natural variantiVAR_0415992434P → A1 PublicationCorresponds to variant dbSNP:rs33972295EnsemblClinVar.1
Natural variantiVAR_0416002438E → K in a breast pleomorphic lobular carcinoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_0416012537E → Q in a breast infiltrating ductal carcinoma sample; somatic mutation. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_013305450E → D in isoform 2. 1 Publication1
Alternative sequenceiVSP_013304451 – 514Missing in isoform 2. 1 PublicationAdd BLAST64
Alternative sequenceiVSP_0369072588 – 2610AKTHV…RNRVT → VSRRYSLIWAVVLISTNELD MQL in isoform 3. 1 PublicationAdd BLAST23
Alternative sequenceiVSP_0369082611 – 2644Missing in isoform 3. 1 PublicationAdd BLAST34

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y09077 mRNA Translation: CAA70298.1
U76308 mRNA Translation: AAC50929.1
U49844 mRNA Translation: AAC50405.1
AF325699 Genomic DNA Translation: AAK26749.1
AB208847 mRNA Translation: BAD92084.1
CCDSiCCDS3124.1 [Q13535-1]
RefSeqiNP_001175.2, NM_001184.3 [Q13535-1]
XP_016862132.1, XM_017006643.1
UniGeneiHs.271791

Genome annotation databases

EnsembliENST00000350721; ENSP00000343741; ENSG00000175054 [Q13535-1]
GeneIDi545
KEGGihsa:545
UCSCiuc003eux.5 human [Q13535-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y09077 mRNA Translation: CAA70298.1
U76308 mRNA Translation: AAC50929.1
U49844 mRNA Translation: AAC50405.1
AF325699 Genomic DNA Translation: AAK26749.1
AB208847 mRNA Translation: BAD92084.1
CCDSiCCDS3124.1 [Q13535-1]
RefSeqiNP_001175.2, NM_001184.3 [Q13535-1]
XP_016862132.1, XM_017006643.1
UniGeneiHs.271791

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5YZ0electron microscopy4.70A/B1-2644[»]
ProteinModelPortaliQ13535
SMRiQ13535
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107027, 128 interactors
ComplexPortaliCPX-3622 ATR-ATRIP DNA damage-sensing kinase complex
CORUMiQ13535
DIPiDIP-35308N
IntActiQ13535, 25 interactors
MINTiQ13535
STRINGi9606.ENSP00000343741

Chemistry databases

BindingDBiQ13535
ChEMBLiCHEMBL5024
GuidetoPHARMACOLOGYi1935

PTM databases

CarbonylDBiQ13535
iPTMnetiQ13535
PhosphoSitePlusiQ13535

Polymorphism and mutation databases

BioMutaiATR
DMDMi62286460

Proteomic databases

EPDiQ13535
MaxQBiQ13535
PaxDbiQ13535
PeptideAtlasiQ13535
PRIDEiQ13535
ProteomicsDBi59521
59522 [Q13535-2]
59523 [Q13535-3]

Protocols and materials databases

DNASUi545
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000350721; ENSP00000343741; ENSG00000175054 [Q13535-1]
GeneIDi545
KEGGihsa:545
UCSCiuc003eux.5 human [Q13535-1]

Organism-specific databases

CTDi545
DisGeNETi545
EuPathDBiHostDB:ENSG00000175054.14
GeneCardsiATR
GeneReviewsiATR
H-InvDBiHIX0030886
HGNCiHGNC:882 ATR
HPAiHPA054320
MalaCardsiATR
MIMi210600 phenotype
601215 gene
614564 phenotype
neXtProtiNX_Q13535
OpenTargetsiENSG00000175054
Orphaneti313846 Familial cutaneous telangiectasia and oropharyngeal cancer predisposition syndrome
808 Seckel syndrome
PharmGKBiPA74
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0890 Eukaryota
COG5032 LUCA
GeneTreeiENSGT00930000150922
HOGENOMiHOG000034221
HOVERGENiHBG050619
InParanoidiQ13535
KOiK06640
OMAiWMLLPHF
OrthoDBiEOG091G013Q
PhylomeDBiQ13535
TreeFamiTF101183

Enzyme and pathway databases

ReactomeiR-HSA-1221632 Meiotic synapsis
R-HSA-176187 Activation of ATR in response to replication stress
R-HSA-3371453 Regulation of HSF1-mediated heat shock response
R-HSA-5685938 HDR through Single Strand Annealing (SSA)
R-HSA-5693607 Processing of DNA double-strand break ends
R-HSA-5693616 Presynaptic phase of homologous DNA pairing and strand exchange
R-HSA-6783310 Fanconi Anemia Pathway
R-HSA-6796648 TP53 Regulates Transcription of DNA Repair Genes
R-HSA-6804756 Regulation of TP53 Activity through Phosphorylation
R-HSA-69473 G2/M DNA damage checkpoint
SignaLinkiQ13535
SIGNORiQ13535

Miscellaneous databases

ChiTaRSiATR human
GeneWikiiAtaxia_telangiectasia_and_Rad3_related
GenomeRNAii545
PROiPR:Q13535
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000175054 Expressed in 225 organ(s), highest expression level in endometrium
CleanExiHS_ATR
ExpressionAtlasiQ13535 baseline and differential
GenevisibleiQ13535 HS

Family and domain databases

Gene3Di1.10.1070.11, 1 hit
1.25.10.10, 2 hits
1.25.40.10, 1 hit
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR003152 FATC_dom
IPR021133 HEAT_type_2
IPR011009 Kinase-like_dom_sf
IPR000403 PI3/4_kinase_cat_dom
IPR036940 PI3/4_kinase_cat_sf
IPR018936 PI3/4_kinase_CS
IPR003151 PIK-rel_kinase_FAT
IPR014009 PIK_FAT
IPR011990 TPR-like_helical_dom_sf
IPR012993 UME
PfamiView protein in Pfam
PF02259 FAT, 1 hit
PF02260 FATC, 1 hit
PF00454 PI3_PI4_kinase, 1 hit
PF08064 UME, 1 hit
SMARTiView protein in SMART
SM01343 FATC, 1 hit
SM00146 PI3Kc, 1 hit
SM00802 UME, 1 hit
SUPFAMiSSF48371 SSF48371, 2 hits
SSF48452 SSF48452, 1 hit
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS51189 FAT, 1 hit
PS51190 FATC, 1 hit
PS50077 HEAT_REPEAT, 1 hit
PS00916 PI3_4_KINASE_2, 1 hit
PS50290 PI3_4_KINASE_3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiATR_HUMAN
AccessioniPrimary (citable) accession number: Q13535
Secondary accession number(s): Q59HB2
, Q7KYL3, Q93051, Q9BXK4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 29, 2005
Last sequence update: July 5, 2004
Last modified: November 7, 2018
This is version 179 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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