UniProtKB - Q13535 (ATR_HUMAN)
Serine/threonine-protein kinase ATR
ATR
Functioni
Catalytic activityi
Cofactori
Activity regulationi
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- DNA binding Source: UniProtKB-KW
- MutLalpha complex binding Source: MGI
- MutSalpha complex binding Source: MGI
- protein kinase activity Source: UniProtKB
- protein serine/threonine kinase activity Source: UniProtKB
GO - Biological processi
- cellular response to DNA damage stimulus Source: UniProtKB
- cellular response to gamma radiation Source: BHF-UCL
- cellular response to UV Source: BHF-UCL
- DNA damage checkpoint Source: UniProtKB
- DNA repair Source: ProtInc
- DNA replication Source: Reactome
- establishment of protein-containing complex localization to telomere Source: BHF-UCL
- establishment of RNA localization to telomere Source: BHF-UCL
- interstrand cross-link repair Source: Reactome
- multicellular organism development Source: ProtInc
- negative regulation of DNA replication Source: UniProtKB
- peptidyl-serine phosphorylation Source: BHF-UCL
- positive regulation of DNA damage response, signal transduction by p53 class mediator Source: BHF-UCL
- positive regulation of telomerase catalytic core complex assembly Source: BHF-UCL
- positive regulation of telomere maintenance via telomerase Source: BHF-UCL
- protein autophosphorylation Source: BHF-UCL
- protein localization to chromosome, telomeric region Source: BHF-UCL
- regulation of cellular response to heat Source: Reactome
- regulation of signal transduction by p53 class mediator Source: Reactome
- replicative senescence Source: BHF-UCL
- response to drug Source: Ensembl
- telomere maintenance Source: GO_Central
Keywordsi
Molecular function | DNA-binding, Kinase, Serine/threonine-protein kinase, Transferase |
Biological process | DNA damage, DNA repair |
Ligand | ATP-binding, Manganese, Nucleotide-binding |
Enzyme and pathway databases
PathwayCommonsi | Q13535 |
Reactomei | R-HSA-1221632, Meiotic synapsis R-HSA-176187, Activation of ATR in response to replication stress R-HSA-3371453, Regulation of HSF1-mediated heat shock response R-HSA-5685938, HDR through Single Strand Annealing (SSA) R-HSA-5693607, Processing of DNA double-strand break ends R-HSA-5693616, Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-6783310, Fanconi Anemia Pathway R-HSA-6796648, TP53 Regulates Transcription of DNA Repair Genes R-HSA-6804756, Regulation of TP53 Activity through Phosphorylation R-HSA-69473, G2/M DNA damage checkpoint |
SignaLinki | Q13535 |
SIGNORi | Q13535 |
Names & Taxonomyi
Protein namesi | Recommended name: Serine/threonine-protein kinase ATR (EC:2.7.11.1)Alternative name(s): Ataxia telangiectasia and Rad3-related protein FRAP-related protein 1 |
Gene namesi | Name:ATR Synonyms:FRP1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000175054.14 |
HGNCi | HGNC:882, ATR |
MIMi | 601215, gene |
neXtProti | NX_Q13535 |
Subcellular locationi
Nucleus
Other locations
- Chromosome By similarity
Note: Depending on the cell type, it can also be found in PML nuclear bodies. Recruited to chromatin during S-phase. Redistributes to discrete nuclear foci upon DNA damage, hypoxia or replication fork stalling.
Golgi apparatus
- Golgi apparatus Source: HPA
Nucleus
- nucleoplasm Source: HPA
- nucleus Source: GO_Central
- PML body Source: UniProtKB
Other locations
- chromosome Source: UniProtKB
Keywords - Cellular componenti
Chromosome, NucleusPathology & Biotechi
Involvement in diseasei
Seckel syndrome 1 (SCKL1)1 Publication
Cutaneous telangiectasia and cancer syndrome, familial (FCTCS)1 Publication
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_067919 | 2144 | Q → R in FCTCS. 1 PublicationCorresponds to variant dbSNP:rs387906797EnsemblClinVar. | 1 |
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 2327 | K → R: Abolishes kinase activity. 3 Publications | 1 | |
Mutagenesisi | 2475 | D → A: Abolishes kinase activity; increases sensitivity to IR and impairs translocation to nuclear foci upon DNA damage. 3 Publications | 1 | |
Mutagenesisi | 2494 | D → E: Abolishes kinase activity; reduces cell viability, augments sensitivity to IR and UV. 2 Publications | 1 |
Keywords - Diseasei
Disease mutation, Dwarfism, Mental retardationOrganism-specific databases
DisGeNETi | 545 |
MalaCardsi | ATR |
MIMi | 210600, phenotype 614564, phenotype |
OpenTargetsi | ENSG00000175054 |
Orphaneti | 313846, Familial cutaneous telangiectasia and oropharyngeal cancer predisposition syndrome 808, Seckel syndrome |
PharmGKBi | PA74 |
Miscellaneous databases
Pharosi | Q13535, Tchem |
Chemistry databases
ChEMBLi | CHEMBL5024 |
GuidetoPHARMACOLOGYi | 1935 |
Polymorphism and mutation databases
BioMutai | ATR |
DMDMi | 62286460 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000088844 | 1 – 2644 | Serine/threonine-protein kinase ATRAdd BLAST | 2644 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 428 | PhosphoserineCombined sources1 Publication | 1 | |
Modified residuei | 435 | PhosphoserineCombined sources | 1 | |
Modified residuei | 436 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1989 | PhosphothreonineCombined sources | 1 |
Post-translational modificationi
Keywords - PTMi
PhosphoproteinProteomic databases
CPTACi | CPTAC-3214 CPTAC-3215 |
EPDi | Q13535 |
jPOSTi | Q13535 |
MassIVEi | Q13535 |
MaxQBi | Q13535 |
PaxDbi | Q13535 |
PeptideAtlasi | Q13535 |
PRIDEi | Q13535 |
ProteomicsDBi | 59521 [Q13535-1] 59522 [Q13535-2] 59523 [Q13535-3] |
PTM databases
CarbonylDBi | Q13535 |
iPTMneti | Q13535 |
PhosphoSitePlusi | Q13535 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000175054, Expressed in endometrium and 237 other tissues |
ExpressionAtlasi | Q13535, baseline and differential |
Genevisiblei | Q13535, HS |
Organism-specific databases
HPAi | ENSG00000175054, Low tissue specificity |
Interactioni
Subunit structurei
Interacts with ATRIP; forming a heterodimer with ATRIP (PubMed:11721054). Binds to DNA, and to UV-damaged DNA with higher affinity.
Interacts with RAD17, MSH2 and HDAC2. Present in a complex containing ATRIP and RPA-coated single-stranded DNA. Present in a complex containing CHD4 and HDAC2.
Interacts with BCR-ABL after genotoxic stress.
Interacts with EEF1E1. This interaction is enhanced by UV irradiation.
Interacts with CLSPN and CEP164.
Interacts with TELO2 and TTI1.
By similarity15 PublicationsBinary interactionsi
Hide detailsQ13535
Protein-protein interaction databases
BioGRIDi | 107027, 153 interactors |
ComplexPortali | CPX-3622, ATR-ATRIP DNA damage-sensing kinase complex |
CORUMi | Q13535 |
DIPi | DIP-35308N |
IntActi | Q13535, 52 interactors |
MINTi | Q13535 |
STRINGi | 9606.ENSP00000343741 |
Chemistry databases
BindingDBi | Q13535 |
Miscellaneous databases
RNActi | Q13535, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 799 – 835 | HEAT 1Add BLAST | 37 | |
Repeati | 1329 – 1365 | HEAT 2Add BLAST | 37 | |
Domaini | 1640 – 2185 | FATPROSITE-ProRule annotationAdd BLAST | 546 | |
Domaini | 2322 – 2567 | PI3K/PI4KPROSITE-ProRule annotationAdd BLAST | 246 | |
Domaini | 2612 – 2644 | FATCPROSITE-ProRule annotationAdd BLAST | 33 |
Sequence similaritiesi
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | KOG0890, Eukaryota |
GeneTreei | ENSGT00940000155714 |
HOGENOMi | CLU_000178_2_1_1 |
InParanoidi | Q13535 |
OMAi | WMLLPHF |
OrthoDBi | 80538at2759 |
PhylomeDBi | Q13535 |
TreeFami | TF101183 |
Family and domain databases
Gene3Di | 1.10.1070.11, 1 hit 1.25.10.10, 2 hits 1.25.40.10, 1 hit |
InterProi | View protein in InterPro IPR011989, ARM-like IPR016024, ARM-type_fold IPR003152, FATC_dom IPR021133, HEAT_type_2 IPR011009, Kinase-like_dom_sf IPR000403, PI3/4_kinase_cat_dom IPR036940, PI3/4_kinase_cat_sf IPR018936, PI3/4_kinase_CS IPR003151, PIK-rel_kinase_FAT IPR014009, PIK_FAT IPR011990, TPR-like_helical_dom_sf IPR012993, UME |
Pfami | View protein in Pfam PF02259, FAT, 1 hit PF02260, FATC, 1 hit PF00454, PI3_PI4_kinase, 1 hit PF08064, UME, 1 hit |
SMARTi | View protein in SMART SM01343, FATC, 1 hit SM00146, PI3Kc, 1 hit SM00802, UME, 1 hit |
SUPFAMi | SSF48371, SSF48371, 2 hits SSF48452, SSF48452, 1 hit SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS51189, FAT, 1 hit PS51190, FATC, 1 hit PS50077, HEAT_REPEAT, 1 hit PS00916, PI3_4_KINASE_2, 1 hit PS50290, PI3_4_KINASE_3, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MGEHGLELAS MIPALRELGS ATPEEYNTVV QKPRQILCQF IDRILTDVNV
60 70 80 90 100
VAVELVKKTD SQPTSVMLLD FIQHIMKSSP LMFVNVSGSH EAKGSCIEFS
110 120 130 140 150
NWIITRLLRI AATPSCHLLH KKICEVICSL LFLFKSKSPA IFGVLTKELL
160 170 180 190 200
QLFEDLVYLH RRNVMGHAVE WPVVMSRFLS QLDEHMGYLQ SAPLQLMSMQ
210 220 230 240 250
NLEFIEVTLL MVLTRIIAIV FFRRQELLLW QIGCVLLEYG SPKIKSLAIS
260 270 280 290 300
FLTELFQLGG LPAQPASTFF SSFLELLKHL VEMDTDQLKL YEEPLSKLIK
310 320 330 340 350
TLFPFEAEAY RNIEPVYLNM LLEKLCVMFE DGVLMRLKSD LLKAALCHLL
360 370 380 390 400
QYFLKFVPAG YESALQVRKV YVRNICKALL DVLGIEVDAE YLLGPLYAAL
410 420 430 440 450
KMESMEIIEE IQCQTQQENL SSNSDGISPK RRRLSSSLNP SKRAPKQTEE
460 470 480 490 500
IKHVDMNQKS ILWSALKQKA ESLQISLEYS GLKNPVIEML EGIAVVLQLT
510 520 530 540 550
ALCTVHCSHQ NMNCRTFKDC QHKSKKKPSV VITWMSLDFY TKVLKSCRSL
560 570 580 590 600
LESVQKLDLE ATIDKVVKIY DALIYMQVNS SFEDHILEDL CGMLSLPWIY
610 620 630 640 650
SHSDDGCLKL TTFAANLLTL SCRISDSYSP QAQSRCVFLL TLFPRRIFLE
660 670 680 690 700
WRTAVYNWAL QSSHEVIRAS CVSGFFILLQ QQNSCNRVPK ILIDKVKDDS
710 720 730 740 750
DIVKKEFASI LGQLVCTLHG MFYLTSSLTE PFSEHGHVDL FCRNLKATSQ
760 770 780 790 800
HECSSSQLKA SVCKPFLFLL KKKIPSPVKL AFIDNLHHLC KHLDFREDET
810 820 830 840 850
DVKAVLGTLL NLMEDPDKDV RVAFSGNIKH ILESLDSEDG FIKELFVLRM
860 870 880 890 900
KEAYTHAQIS RNNELKDTLI LTTGDIGRAA KGDLVPFALL HLLHCLLSKS
910 920 930 940 950
ASVSGAAYTE IRALVAAKSV KLQSFFSQYK KPICQFLVES LHSSQMTALP
960 970 980 990 1000
NTPCQNADVR KQDVAHQREM ALNTLSEIAN VFDFPDLNRF LTRTLQVLLP
1010 1020 1030 1040 1050
DLAAKASPAA SALIRTLGKQ LNVNRREILI NNFKYIFSHL VCSCSKDELE
1060 1070 1080 1090 1100
RALHYLKNET EIELGSLLRQ DFQGLHNELL LRIGEHYQQV FNGLSILASF
1110 1120 1130 1140 1150
ASSDDPYQGP RDIISPELMA DYLQPKLLGI LAFFNMQLLS SSVGIEDKKM
1160 1170 1180 1190 1200
ALNSLMSLMK LMGPKHVSSV RVKMMTTLRT GLRFKDDFPE LCCRAWDCFV
1210 1220 1230 1240 1250
RCLDHACLGS LLSHVIVALL PLIHIQPKET AAIFHYLIIE NRDAVQDFLH
1260 1270 1280 1290 1300
EIYFLPDHPE LKKIKAVLQE YRKETSESTD LQTTLQLSMK AIQHENVDVR
1310 1320 1330 1340 1350
IHALTSLKET LYKNQEKLIK YATDSETVEP IISQLVTVLL KGCQDANSQA
1360 1370 1380 1390 1400
RLLCGECLGE LGAIDPGRLD FSTTETQGKD FTFVTGVEDS SFAYGLLMEL
1410 1420 1430 1440 1450
TRAYLAYADN SRAQDSAAYA IQELLSIYDC REMETNGPGH QLWRRFPEHV
1460 1470 1480 1490 1500
REILEPHLNT RYKSSQKSTD WSGVKKPIYL SKLGSNFAEW SASWAGYLIT
1510 1520 1530 1540 1550
KVRHDLASKI FTCCSIMMKH DFKVTIYLLP HILVYVLLGC NQEDQQEVYA
1560 1570 1580 1590 1600
EIMAVLKHDD QHTINTQDIA SDLCQLSTQT VFSMLDHLTQ WARHKFQALK
1610 1620 1630 1640 1650
AEKCPHSKSN RNKVDSMVST VDYEDYQSVT RFLDLIPQDT LAVASFRSKA
1660 1670 1680 1690 1700
YTRAVMHFES FITEKKQNIQ EHLGFLQKLY AAMHEPDGVA GVSAIRKAEP
1710 1720 1730 1740 1750
SLKEQILEHE SLGLLRDATA CYDRAIQLEP DQIIHYHGVV KSMLGLGQLS
1760 1770 1780 1790 1800
TVITQVNGVH ANRSEWTDEL NTYRVEAAWK LSQWDLVENY LAADGKSTTW
1810 1820 1830 1840 1850
SVRLGQLLLS AKKRDITAFY DSLKLVRAEQ IVPLSAASFE RGSYQRGYEY
1860 1870 1880 1890 1900
IVRLHMLCEL EHSIKPLFQH SPGDSSQEDS LNWVARLEMT QNSYRAKEPI
1910 1920 1930 1940 1950
LALRRALLSL NKRPDYNEMV GECWLQSARV ARKAGHHQTA YNALLNAGES
1960 1970 1980 1990 2000
RLAELYVERA KWLWSKGDVH QALIVLQKGV ELCFPENETP PEGKNMLIHG
2010 2020 2030 2040 2050
RAMLLVGRFM EETANFESNA IMKKYKDVTA CLPEWEDGHF YLAKYYDKLM
2060 2070 2080 2090 2100
PMVTDNKMEK QGDLIRYIVL HFGRSLQYGN QFIYQSMPRM LTLWLDYGTK
2110 2120 2130 2140 2150
AYEWEKAGRS DRVQMRNDLG KINKVITEHT NYLAPYQFLT AFSQLISRIC
2160 2170 2180 2190 2200
HSHDEVFVVL MEIIAKVFLA YPQQAMWMMT AVSKSSYPMR VNRCKEILNK
2210 2220 2230 2240 2250
AIHMKKSLEK FVGDATRLTD KLLELCNKPV DGSSSTLSMS THFKMLKKLV
2260 2270 2280 2290 2300
EEATFSEILI PLQSVMIPTL PSILGTHANH ASHEPFPGHW AYIAGFDDMV
2310 2320 2330 2340 2350
EILASLQKPK KISLKGSDGK FYIMMCKPKD DLRKDCRLME FNSLINKCLR
2360 2370 2380 2390 2400
KDAESRRREL HIRTYAVIPL NDECGIIEWV NNTAGLRPIL TKLYKEKGVY
2410 2420 2430 2440 2450
MTGKELRQCM LPKSAALSEK LKVFREFLLP RHPPIFHEWF LRTFPDPTSW
2460 2470 2480 2490 2500
YSSRSAYCRS TAVMSMVGYI LGLGDRHGEN ILFDSLTGEC VHVDFNCLFN
2510 2520 2530 2540 2550
KGETFEVPEI VPFRLTHNMV NGMGPMGTEG LFRRACEVTM RLMRDQREPL
2560 2570 2580 2590 2600
MSVLKTFLHD PLVEWSKPVK GHSKAPLNET GEVVNEKAKT HVLDIEQRLQ
2610 2620 2630 2640
GVIKTRNRVT GLPLSIEGHV HYLIQEATDE NLLCQMYLGW TPYM
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A590UJ01 | A0A590UJ01_HUMAN | Serine/threonine-protein kinase ATR | ATR | 2,193 | Annotation score: | ||
D6RIG7 | D6RIG7_HUMAN | Serine/threonine-protein kinase ATR | ATR | 115 | Annotation score: | ||
H0Y8R8 | H0Y8R8_HUMAN | Serine/threonine-protein kinase ATR | ATR | 39 | Annotation score: | ||
D6RFJ6 | D6RFJ6_HUMAN | Serine/threonine-protein kinase ATR | ATR | 100 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 92 | A → R in CAA70298 (PubMed:8978690).Curated | 1 | |
Sequence conflicti | 92 | A → R in AAC50929 (PubMed:8978690).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_041584 | 64 | T → A1 PublicationCorresponds to variant dbSNP:rs35306038EnsemblClinVar. | 1 | |
Natural variantiVAR_041585 | 90 | H → Y1 PublicationCorresponds to variant dbSNP:rs28897763EnsemblClinVar. | 1 | |
Natural variantiVAR_050532 | 211 | M → T. Corresponds to variant dbSNP:rs2227928EnsemblClinVar. | 1 | |
Natural variantiVAR_041586 | 297 | K → N1 PublicationCorresponds to variant dbSNP:rs2229033EnsemblClinVar. | 1 | |
Natural variantiVAR_041587 | 316 | V → I1 PublicationCorresponds to variant dbSNP:rs28897764EnsemblClinVar. | 1 | |
Natural variantiVAR_041588 | 959 | V → M1 PublicationCorresponds to variant dbSNP:rs28910271EnsemblClinVar. | 1 | |
Natural variantiVAR_041589 | 1087 | Y → H1 PublicationCorresponds to variant dbSNP:rs34253059Ensembl. | 1 | |
Natural variantiVAR_041590 | 1213 | S → G1 PublicationCorresponds to variant dbSNP:rs34766606Ensembl. | 1 | |
Natural variantiVAR_041591 | 1488 | A → P in a lung squamous cell carcinoma sample; somatic mutation. 1 Publication | 1 | |
Natural variantiVAR_050533 | 1526 | I → V. Corresponds to variant dbSNP:rs34124242EnsemblClinVar. | 1 | |
Natural variantiVAR_041592 | 1607 | S → N1 PublicationCorresponds to variant dbSNP:rs55724025EnsemblClinVar. | 1 | |
Natural variantiVAR_041593 | 1612 | N → S1 PublicationCorresponds to variant dbSNP:rs55894265EnsemblClinVar. | 1 | |
Natural variantiVAR_041594 | 2002 | A → G in a lung adenocarcinoma sample; somatic mutation. 1 Publication | 1 | |
Natural variantiVAR_041595 | 2120 | G → A1 PublicationCorresponds to variant dbSNP:rs35134774Ensembl. | 1 | |
Natural variantiVAR_041596 | 2132 | Y → D1 PublicationCorresponds to variant dbSNP:rs28910273EnsemblClinVar. | 1 | |
Natural variantiVAR_067919 | 2144 | Q → R in FCTCS. 1 PublicationCorresponds to variant dbSNP:rs387906797EnsemblClinVar. | 1 | |
Natural variantiVAR_041597 | 2233 | S → I in a lung large cell carcinoma sample; somatic mutation. 1 Publication | 1 | |
Natural variantiVAR_041598 | 2425 | R → Q1 PublicationCorresponds to variant dbSNP:rs2229032EnsemblClinVar. | 1 | |
Natural variantiVAR_041599 | 2434 | P → A1 PublicationCorresponds to variant dbSNP:rs33972295EnsemblClinVar. | 1 | |
Natural variantiVAR_041600 | 2438 | E → K in a breast pleomorphic lobular carcinoma sample; somatic mutation. 1 Publication | 1 | |
Natural variantiVAR_041601 | 2537 | E → Q in a breast infiltrating ductal carcinoma sample; somatic mutation. 1 Publication | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_013305 | 450 | E → D in isoform 2. 1 Publication | 1 | |
Alternative sequenceiVSP_013304 | 451 – 514 | Missing in isoform 2. 1 PublicationAdd BLAST | 64 | |
Alternative sequenceiVSP_036907 | 2588 – 2610 | AKTHV…RNRVT → VSRRYSLIWAVVLISTNELD MQL in isoform 3. 1 PublicationAdd BLAST | 23 | |
Alternative sequenceiVSP_036908 | 2611 – 2644 | Missing in isoform 3. 1 PublicationAdd BLAST | 34 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Y09077 mRNA Translation: CAA70298.1 U76308 mRNA Translation: AAC50929.1 U49844 mRNA Translation: AAC50405.1 AF325699 Genomic DNA Translation: AAK26749.1 AB208847 mRNA Translation: BAD92084.1 |
CCDSi | CCDS3124.1 [Q13535-1] |
RefSeqi | NP_001175.2, NM_001184.3 [Q13535-1] XP_016862132.1, XM_017006643.1 |
Genome annotation databases
Ensembli | ENST00000350721; ENSP00000343741; ENSG00000175054 [Q13535-1] ENST00000661310; ENSP00000499589; ENSG00000175054 [Q13535-2] |
GeneIDi | 545 |
KEGGi | hsa:545 |
UCSCi | uc003eux.5, human [Q13535-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Web resourcesi
Atlas of Genetics and Cytogenetics in Oncology and Haematology |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Y09077 mRNA Translation: CAA70298.1 U76308 mRNA Translation: AAC50929.1 U49844 mRNA Translation: AAC50405.1 AF325699 Genomic DNA Translation: AAK26749.1 AB208847 mRNA Translation: BAD92084.1 |
CCDSi | CCDS3124.1 [Q13535-1] |
RefSeqi | NP_001175.2, NM_001184.3 [Q13535-1] XP_016862132.1, XM_017006643.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
5YZ0 | electron microscopy | 4.70 | A/B | 1-2644 | [»] | |
SMRi | Q13535 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 107027, 153 interactors |
ComplexPortali | CPX-3622, ATR-ATRIP DNA damage-sensing kinase complex |
CORUMi | Q13535 |
DIPi | DIP-35308N |
IntActi | Q13535, 52 interactors |
MINTi | Q13535 |
STRINGi | 9606.ENSP00000343741 |
Chemistry databases
BindingDBi | Q13535 |
ChEMBLi | CHEMBL5024 |
GuidetoPHARMACOLOGYi | 1935 |
PTM databases
CarbonylDBi | Q13535 |
iPTMneti | Q13535 |
PhosphoSitePlusi | Q13535 |
Polymorphism and mutation databases
BioMutai | ATR |
DMDMi | 62286460 |
Proteomic databases
CPTACi | CPTAC-3214 CPTAC-3215 |
EPDi | Q13535 |
jPOSTi | Q13535 |
MassIVEi | Q13535 |
MaxQBi | Q13535 |
PaxDbi | Q13535 |
PeptideAtlasi | Q13535 |
PRIDEi | Q13535 |
ProteomicsDBi | 59521 [Q13535-1] 59522 [Q13535-2] 59523 [Q13535-3] |
Protocols and materials databases
Antibodypediai | 18078, 511 antibodies |
CPTCi | Q13535, 1 antibody |
DNASUi | 545 |
Genome annotation databases
Ensembli | ENST00000350721; ENSP00000343741; ENSG00000175054 [Q13535-1] ENST00000661310; ENSP00000499589; ENSG00000175054 [Q13535-2] |
GeneIDi | 545 |
KEGGi | hsa:545 |
UCSCi | uc003eux.5, human [Q13535-1] |
Organism-specific databases
CTDi | 545 |
DisGeNETi | 545 |
EuPathDBi | HostDB:ENSG00000175054.14 |
GeneCardsi | ATR |
HGNCi | HGNC:882, ATR |
HPAi | ENSG00000175054, Low tissue specificity |
MalaCardsi | ATR |
MIMi | 210600, phenotype 601215, gene 614564, phenotype |
neXtProti | NX_Q13535 |
OpenTargetsi | ENSG00000175054 |
Orphaneti | 313846, Familial cutaneous telangiectasia and oropharyngeal cancer predisposition syndrome 808, Seckel syndrome |
PharmGKBi | PA74 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0890, Eukaryota |
GeneTreei | ENSGT00940000155714 |
HOGENOMi | CLU_000178_2_1_1 |
InParanoidi | Q13535 |
OMAi | WMLLPHF |
OrthoDBi | 80538at2759 |
PhylomeDBi | Q13535 |
TreeFami | TF101183 |
Enzyme and pathway databases
PathwayCommonsi | Q13535 |
Reactomei | R-HSA-1221632, Meiotic synapsis R-HSA-176187, Activation of ATR in response to replication stress R-HSA-3371453, Regulation of HSF1-mediated heat shock response R-HSA-5685938, HDR through Single Strand Annealing (SSA) R-HSA-5693607, Processing of DNA double-strand break ends R-HSA-5693616, Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-6783310, Fanconi Anemia Pathway R-HSA-6796648, TP53 Regulates Transcription of DNA Repair Genes R-HSA-6804756, Regulation of TP53 Activity through Phosphorylation R-HSA-69473, G2/M DNA damage checkpoint |
SignaLinki | Q13535 |
SIGNORi | Q13535 |
Miscellaneous databases
BioGRID-ORCSi | 545, 675 hits in 878 CRISPR screens |
ChiTaRSi | ATR, human |
GeneWikii | Ataxia_telangiectasia_and_Rad3_related |
GenomeRNAii | 545 |
Pharosi | Q13535, Tchem |
PROi | PR:Q13535 |
RNActi | Q13535, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000175054, Expressed in endometrium and 237 other tissues |
ExpressionAtlasi | Q13535, baseline and differential |
Genevisiblei | Q13535, HS |
Family and domain databases
Gene3Di | 1.10.1070.11, 1 hit 1.25.10.10, 2 hits 1.25.40.10, 1 hit |
InterProi | View protein in InterPro IPR011989, ARM-like IPR016024, ARM-type_fold IPR003152, FATC_dom IPR021133, HEAT_type_2 IPR011009, Kinase-like_dom_sf IPR000403, PI3/4_kinase_cat_dom IPR036940, PI3/4_kinase_cat_sf IPR018936, PI3/4_kinase_CS IPR003151, PIK-rel_kinase_FAT IPR014009, PIK_FAT IPR011990, TPR-like_helical_dom_sf IPR012993, UME |
Pfami | View protein in Pfam PF02259, FAT, 1 hit PF02260, FATC, 1 hit PF00454, PI3_PI4_kinase, 1 hit PF08064, UME, 1 hit |
SMARTi | View protein in SMART SM01343, FATC, 1 hit SM00146, PI3Kc, 1 hit SM00802, UME, 1 hit |
SUPFAMi | SSF48371, SSF48371, 2 hits SSF48452, SSF48452, 1 hit SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS51189, FAT, 1 hit PS51190, FATC, 1 hit PS50077, HEAT_REPEAT, 1 hit PS00916, PI3_4_KINASE_2, 1 hit PS50290, PI3_4_KINASE_3, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ATR_HUMAN | |
Accessioni | Q13535Primary (citable) accession number: Q13535 Secondary accession number(s): Q59HB2 Q9BXK4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 29, 2005 |
Last sequence update: | July 5, 2004 | |
Last modified: | December 2, 2020 | |
This is version 195 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 3
Human chromosome 3: entries, gene names and cross-references to MIM - Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations - Human and mouse protein kinases
Human and mouse protein kinases: classification and index