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Protein

Serine incorporator 3

Gene

SERINC3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Restriction factor required to restrict infectivity of lentiviruses, such as HIV-1: acts by inhibiting an early step of viral infection. Impairs the penetration of the viral particle into the cytoplasm (PubMed:26416733, PubMed:26416734).2 Publications

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processAntiviral defense, Immunity, Innate immunity

Enzyme and pathway databases

ReactomeiR-HSA-977347 Serine biosynthesis

Protein family/group databases

TCDBi9.A.29.3.4 the lantibiotic immunity protein/serine connector (lip/sip) family

Names & Taxonomyi

Protein namesi
Recommended name:
Serine incorporator 3
Alternative name(s):
Tumor differentially expressed protein 11 Publication
Gene namesi
Name:SERINC3
Synonyms:DIFF33, TDE11 Publication
ORF Names:SBBI991 Publication
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

EuPathDBiHostDB:ENSG00000132824.13
HGNCiHGNC:11699 SERINC3
MIMi607165 gene
neXtProtiNX_Q13530

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 96ExtracellularSequence analysisAdd BLAST96
Transmembranei97 – 117HelicalSequence analysisAdd BLAST21
Topological domaini118 – 132CytoplasmicSequence analysisAdd BLAST15
Transmembranei133 – 153HelicalSequence analysisAdd BLAST21
Topological domaini154 – 159ExtracellularSequence analysis6
Transmembranei160 – 180HelicalSequence analysisAdd BLAST21
Topological domaini181 – 203CytoplasmicSequence analysisAdd BLAST23
Transmembranei204 – 224HelicalSequence analysisAdd BLAST21
Topological domaini225 – 239ExtracellularSequence analysisAdd BLAST15
Transmembranei240 – 260HelicalSequence analysisAdd BLAST21
Topological domaini261 – 329CytoplasmicSequence analysisAdd BLAST69
Transmembranei330 – 350HelicalSequence analysisAdd BLAST21
Topological domaini351 – 406ExtracellularSequence analysisAdd BLAST56
Transmembranei407 – 427HelicalSequence analysisAdd BLAST21
Topological domaini428 – 446CytoplasmicSequence analysisAdd BLAST19
Transmembranei447 – 467HelicalSequence analysisAdd BLAST21
Topological domaini468 – 473ExtracellularSequence analysis6

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi10955
OpenTargetsiENSG00000132824
PharmGKBiPA36418

Polymorphism and mutation databases

BioMutaiSERINC3
DMDMi25453293

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002189701 – 473Serine incorporator 3Add BLAST473

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi34N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei371PhosphoserineBy similarity1

Post-translational modificationi

N-glycosylated.By similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

EPDiQ13530
MaxQBiQ13530
PaxDbiQ13530
PeptideAtlasiQ13530
PRIDEiQ13530
ProteomicsDBi59520

PTM databases

iPTMnetiQ13530
PhosphoSitePlusiQ13530
SwissPalmiQ13530

Expressioni

Tissue specificityi

Ubiquitous. Expression levels were increased fourfold to tenfold in lung tumor tissues compared with normal pulmonary tissues.1 Publication

Gene expression databases

BgeeiENSG00000132824 Expressed in 239 organ(s), highest expression level in tendon
CleanExiHS_SERINC3
ExpressionAtlasiQ13530 baseline and differential
GenevisibleiQ13530 HS

Organism-specific databases

HPAiHPA048116

Interactioni

Protein-protein interaction databases

BioGridi116155, 12 interactors
IntActiQ13530, 3 interactors
STRINGi9606.ENSP00000255175

Structurei

3D structure databases

ProteinModelPortaliQ13530
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TDE1 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2592 Eukaryota
ENOG410XP7K LUCA
GeneTreeiENSGT00550000074522
HOGENOMiHOG000165463
HOVERGENiHBG025699
InParanoidiQ13530
OMAiRMEEGNP
OrthoDBiEOG091G07WS
PhylomeDBiQ13530
TreeFamiTF312881

Family and domain databases

InterProiView protein in InterPro
IPR029557 Serinc3
IPR005016 TDE1/TMS
PANTHERiPTHR10383 PTHR10383, 1 hit
PTHR10383:SF27 PTHR10383:SF27, 1 hit
PfamiView protein in Pfam
PF03348 Serinc, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q13530-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGAVLGVFSL ASWVPCLCSG ASCLLCSCCP NSKNSTVTRL IYAFILLLST
60 70 80 90 100
VVSYIMQRKE METYLKKIPG FCEGGFKIHE ADINADKDCD VLVGYKAVYR
110 120 130 140 150
ISFAMAIFFF VFSLLMFKVK TSKDLRAAVH NGFWFFKIAA LIGIMVGSFY
160 170 180 190 200
IPGGYFSSVW FVVGMIGAAL FILIQLVLLV DFAHSWNESW VNRMEEGNPR
210 220 230 240 250
LWYAALLSFT SAFYILSIIC VGLLYTYYTK PDGCTENKFF ISINLILCVV
260 270 280 290 300
ASIISIHPKI QEHQPRSGLL QSSLITLYTM YLTWSAMSNE PDRSCNPNLM
310 320 330 340 350
SFITRITAPT LAPGNSTAVV PTPTPPSKSG SLLDSDNFIG LFVFVLCLLY
360 370 380 390 400
SSIRTSTNSQ VDKLTLSGSD SVILGDTTTS GASDEEDGQP RRAVDNEKEG
410 420 430 440 450
VQYSYSLFHL MLCLASLYIM MTLTSWYSPD AKFQSMTSKW PAVWVKISSS
460 470
WVCLLLYVWT LVAPLVLTSR DFS
Length:473
Mass (Da):52,580
Last modified:November 25, 2002 - v2
Checksum:i9DCB04B2A0AB1132
GO
Isoform 2 (identifier: Q13530-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-55: Missing.

Note: No experimental confirmation available.
Show »
Length:418
Mass (Da):46,821
Checksum:i6EB1F9F980ECFB6F
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5H936Q5H936_HUMAN
Serine incorporator 3
SERINC3
212Annotation score:

Sequence cautioni

The sequence AAB48858 differs from that shown. Reason: Frameshift at positions 321, 393, 407 and 459.Curated
The sequence AAD34641 differs from that shown. Reason: Frameshift at positions 321, 393, 407 and 459.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_014315437T → A1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0568331 – 55Missing in isoform 2. 1 PublicationAdd BLAST55

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF112227 mRNA Translation: AAD22448.1
U49188 mRNA Translation: AAB48858.1 Frameshift.
AF153979 mRNA Translation: AAD34641.1 Frameshift.
AK300618 mRNA Translation: BAG62311.1
Z97053 Genomic DNA No translation available.
BC006088 mRNA Translation: AAH06088.1
CCDSiCCDS13333.1 [Q13530-1]
RefSeqiNP_006802.1, NM_006811.3 [Q13530-1]
NP_945179.1, NM_198941.2 [Q13530-1]
XP_016883090.1, XM_017027601.1 [Q13530-2]
UniGeneiHs.272168
Hs.696712
Hs.744982

Genome annotation databases

EnsembliENST00000255175; ENSP00000255175; ENSG00000132824 [Q13530-1]
ENST00000342374; ENSP00000340243; ENSG00000132824 [Q13530-1]
GeneIDi10955
KEGGihsa:10955
UCSCiuc002xme.4 human [Q13530-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF112227 mRNA Translation: AAD22448.1
U49188 mRNA Translation: AAB48858.1 Frameshift.
AF153979 mRNA Translation: AAD34641.1 Frameshift.
AK300618 mRNA Translation: BAG62311.1
Z97053 Genomic DNA No translation available.
BC006088 mRNA Translation: AAH06088.1
CCDSiCCDS13333.1 [Q13530-1]
RefSeqiNP_006802.1, NM_006811.3 [Q13530-1]
NP_945179.1, NM_198941.2 [Q13530-1]
XP_016883090.1, XM_017027601.1 [Q13530-2]
UniGeneiHs.272168
Hs.696712
Hs.744982

3D structure databases

ProteinModelPortaliQ13530
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116155, 12 interactors
IntActiQ13530, 3 interactors
STRINGi9606.ENSP00000255175

Protein family/group databases

TCDBi9.A.29.3.4 the lantibiotic immunity protein/serine connector (lip/sip) family

PTM databases

iPTMnetiQ13530
PhosphoSitePlusiQ13530
SwissPalmiQ13530

Polymorphism and mutation databases

BioMutaiSERINC3
DMDMi25453293

Proteomic databases

EPDiQ13530
MaxQBiQ13530
PaxDbiQ13530
PeptideAtlasiQ13530
PRIDEiQ13530
ProteomicsDBi59520

Protocols and materials databases

DNASUi10955
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000255175; ENSP00000255175; ENSG00000132824 [Q13530-1]
ENST00000342374; ENSP00000340243; ENSG00000132824 [Q13530-1]
GeneIDi10955
KEGGihsa:10955
UCSCiuc002xme.4 human [Q13530-1]

Organism-specific databases

CTDi10955
DisGeNETi10955
EuPathDBiHostDB:ENSG00000132824.13
GeneCardsiSERINC3
HGNCiHGNC:11699 SERINC3
HPAiHPA048116
MIMi607165 gene
neXtProtiNX_Q13530
OpenTargetsiENSG00000132824
PharmGKBiPA36418
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2592 Eukaryota
ENOG410XP7K LUCA
GeneTreeiENSGT00550000074522
HOGENOMiHOG000165463
HOVERGENiHBG025699
InParanoidiQ13530
OMAiRMEEGNP
OrthoDBiEOG091G07WS
PhylomeDBiQ13530
TreeFamiTF312881

Enzyme and pathway databases

ReactomeiR-HSA-977347 Serine biosynthesis

Miscellaneous databases

ChiTaRSiSERINC3 human
GeneWikiiSERINC3
GenomeRNAii10955
PROiPR:Q13530
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000132824 Expressed in 239 organ(s), highest expression level in tendon
CleanExiHS_SERINC3
ExpressionAtlasiQ13530 baseline and differential
GenevisibleiQ13530 HS

Family and domain databases

InterProiView protein in InterPro
IPR029557 Serinc3
IPR005016 TDE1/TMS
PANTHERiPTHR10383 PTHR10383, 1 hit
PTHR10383:SF27 PTHR10383:SF27, 1 hit
PfamiView protein in Pfam
PF03348 Serinc, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSERC3_HUMAN
AccessioniPrimary (citable) accession number: Q13530
Secondary accession number(s): B4DUE9, O43717, Q9BR33
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 25, 2002
Last sequence update: November 25, 2002
Last modified: November 7, 2018
This is version 153 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
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