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Protein

Protein phosphatase 1 regulatory subunit 1A

Gene

PPP1R1A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Inhibitor of protein-phosphatase 1. This protein may be important in hormonal control of glycogen metabolism. Hormones that elevate intracellular cAMP increase I-1 activity in many tissues. I-1 activation may impose cAMP control over proteins that are not directly phosphorylated by PKA. Following a rise in intracellular calcium, I-1 is inactivated by calcineurin (or PP2B). Does not inhibit type-2 phosphatases.

GO - Molecular functioni

  • protein serine/threonine phosphatase inhibitor activity Source: ProtInc

GO - Biological processi

Keywordsi

Molecular functionProtein phosphatase inhibitor
Biological processCarbohydrate metabolism, Glycogen metabolism

Enzyme and pathway databases

SIGNORiQ13522

Names & Taxonomyi

Protein namesi
Recommended name:
Protein phosphatase 1 regulatory subunit 1A
Alternative name(s):
Protein phosphatase inhibitor 1
Short name:
I-1
Short name:
IPP-1
Gene namesi
Name:PPP1R1A
Synonyms:IPP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000135447.16
HGNCiHGNC:9286 PPP1R1A
MIMi613246 gene
neXtProtiNX_Q13522

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi35T → A: No activity. 1 Publication1
Mutagenesisi35T → D: 1000-fold reduction in activity, inhibits equally PP1 and PP2A. 1 Publication1

Organism-specific databases

DisGeNETi5502
PharmGKBiPA33636

Polymorphism and mutation databases

BioMutaiPPP1R1A
DMDMi296452864

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000714771 – 171Protein phosphatase 1 regulatory subunit 1AAdd BLAST171

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei35Phosphothreonine; by PKA1 Publication1
Modified residuei43PhosphoserineBy similarity1
Modified residuei46PhosphoserineBy similarity1
Modified residuei47PhosphoserineBy similarity1
Modified residuei67PhosphoserineCombined sources1

Post-translational modificationi

Phosphorylation of Thr-35 is required for activity.1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ13522
PaxDbiQ13522
PeptideAtlasiQ13522
PRIDEiQ13522
ProteomicsDBi59517

PTM databases

iPTMnetiQ13522
PhosphoSitePlusiQ13522

Expressioni

Gene expression databases

BgeeiENSG00000135447 Expressed in 200 organ(s), highest expression level in adipose tissue
CleanExiHS_PPP1R1A
ExpressionAtlasiQ13522 baseline and differential
GenevisibleiQ13522 HS

Organism-specific databases

HPAiCAB007811
HPA041542

Interactioni

Subunit structurei

Interacts with PPP1R15A.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
PPP1R15AO758074EBI-1568511,EBI-714746

Protein-protein interaction databases

BioGridi111496, 15 interactors
IntActiQ13522, 2 interactors
STRINGi9606.ENSP00000257905

Chemistry databases

BindingDBiQ13522

Structurei

3D structure databases

ProteinModelPortaliQ13522
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni9 – 12Essential for activity4
Regioni42 – 54Essential for activityCuratedAdd BLAST13
Regioni143 – 171Interaction with PPP1R15A1 PublicationAdd BLAST29

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG410J0ZP Eukaryota
ENOG41125ZM LUCA
HOGENOMiHOG000115665
HOVERGENiHBG096069
InParanoidiQ13522
KOiK08050
OrthoDBiEOG091G1A3V
PhylomeDBiQ13522
TreeFamiTF332576

Family and domain databases

InterProiView protein in InterPro
IPR008466 PPP1R1A/B/C
PANTHERiPTHR15417 PTHR15417, 1 hit
PfamiView protein in Pfam
PF05395 DARPP-32, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q13522-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEQDNSPRKI QFTVPLLEPH LDPEAAEQIR RRRPTPATLV LTSDQSSPEI
60 70 80 90 100
DEDRIPNPHL KSTLAMSPRQ RKKMTRITPT MKELQMMVEH HLGQQQQGEE
110 120 130 140 150
PEGAAESTET QESRPPGIPD TEVESRLGTS GTAKKTAECI PKTHERGSKE
160 170
PSTKEPSTHI PPLDSKGANS V
Length:171
Mass (Da):19,011
Last modified:May 18, 2010 - v2
Checksum:i6F61FF08E4305729
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8VR76F8VR76_HUMAN
Protein phosphatase 1 regulatory su...
PPP1R1A
64Annotation score:
R4GMQ8R4GMQ8_HUMAN
Protein phosphatase 1 regulatory su...
PPP1R1A
153Annotation score:
H0YIU4H0YIU4_HUMAN
Protein phosphatase 1 regulatory su...
PPP1R1A
90Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti8R → Q in AAH22470 (PubMed:15489334).Curated1
Sequence conflicti43S → G in AAL48321 (Ref. 2) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_053898109E → G4 PublicationsCorresponds to variant dbSNP:rs1249958Ensembl.1
Natural variantiVAR_053899147G → D. Corresponds to variant dbSNP:rs34376731Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U48707 mRNA Translation: AAB02402.1
AY063766 mRNA Translation: AAL48321.1
CR457003 mRNA Translation: CAG33284.1
BC022470 mRNA Translation: AAH22470.1
CCDSiCCDS44912.1
RefSeqiNP_006732.3, NM_006741.3
UniGeneiHs.505662

Genome annotation databases

EnsembliENST00000257905; ENSP00000257905; ENSG00000135447
GeneIDi5502
KEGGihsa:5502
UCSCiuc001sgg.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U48707 mRNA Translation: AAB02402.1
AY063766 mRNA Translation: AAL48321.1
CR457003 mRNA Translation: CAG33284.1
BC022470 mRNA Translation: AAH22470.1
CCDSiCCDS44912.1
RefSeqiNP_006732.3, NM_006741.3
UniGeneiHs.505662

3D structure databases

ProteinModelPortaliQ13522
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111496, 15 interactors
IntActiQ13522, 2 interactors
STRINGi9606.ENSP00000257905

Chemistry databases

BindingDBiQ13522

PTM databases

iPTMnetiQ13522
PhosphoSitePlusiQ13522

Polymorphism and mutation databases

BioMutaiPPP1R1A
DMDMi296452864

Proteomic databases

EPDiQ13522
PaxDbiQ13522
PeptideAtlasiQ13522
PRIDEiQ13522
ProteomicsDBi59517

Protocols and materials databases

DNASUi5502
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000257905; ENSP00000257905; ENSG00000135447
GeneIDi5502
KEGGihsa:5502
UCSCiuc001sgg.3 human

Organism-specific databases

CTDi5502
DisGeNETi5502
EuPathDBiHostDB:ENSG00000135447.16
GeneCardsiPPP1R1A
HGNCiHGNC:9286 PPP1R1A
HPAiCAB007811
HPA041542
MIMi613246 gene
neXtProtiNX_Q13522
PharmGKBiPA33636
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J0ZP Eukaryota
ENOG41125ZM LUCA
HOGENOMiHOG000115665
HOVERGENiHBG096069
InParanoidiQ13522
KOiK08050
OrthoDBiEOG091G1A3V
PhylomeDBiQ13522
TreeFamiTF332576

Enzyme and pathway databases

SIGNORiQ13522

Miscellaneous databases

GenomeRNAii5502
PROiPR:Q13522
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000135447 Expressed in 200 organ(s), highest expression level in adipose tissue
CleanExiHS_PPP1R1A
ExpressionAtlasiQ13522 baseline and differential
GenevisibleiQ13522 HS

Family and domain databases

InterProiView protein in InterPro
IPR008466 PPP1R1A/B/C
PANTHERiPTHR15417 PTHR15417, 1 hit
PfamiView protein in Pfam
PF05395 DARPP-32, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPPR1A_HUMAN
AccessioniPrimary (citable) accession number: Q13522
Secondary accession number(s): Q6IB01, Q8TBJ2, Q8WWV2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 18, 2010
Last modified: September 12, 2018
This is version 136 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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