Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 165 (12 Aug 2020)
Sequence version 2 (04 Nov 2008)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

Aquaporin-6

Gene

AQP6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Forms a water-specific channel that participates in distinct physiological functions such as glomerular filtration, tubular endocytosis and acid-base metabolism.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processTransport

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q13520

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-432047, Passive transport by Aquaporins

Protein family/group databases

Transport Classification Database

More...
TCDBi
1.A.8.8.4, the major intrinsic protein (mip) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Aquaporin-6
Short name:
AQP-6
Alternative name(s):
Aquaporin-2-like
Kidney-specific aquaporin
Short name:
hKID
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:AQP6
Synonyms:AQP2L
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000086159.12

Human Gene Nomenclature Database

More...
HGNCi
HGNC:639, AQP6

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
601383, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q13520

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 30CytoplasmicSequence analysisAdd BLAST30
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei31 – 48HelicalSequence analysisAdd BLAST18
Topological domaini49 – 54ExtracellularSequence analysis6
Transmembranei55 – 73HelicalSequence analysisAdd BLAST19
Topological domaini74 – 99CytoplasmicSequence analysisAdd BLAST26
Transmembranei100 – 121HelicalSequence analysisAdd BLAST22
Topological domaini122 – 141ExtracellularSequence analysisAdd BLAST20
Transmembranei142 – 162HelicalSequence analysisAdd BLAST21
Topological domaini163 – 168CytoplasmicSequence analysis6
Transmembranei169 – 188HelicalSequence analysisAdd BLAST20
Topological domaini189 – 214ExtracellularSequence analysisAdd BLAST26
Transmembranei215 – 236HelicalSequence analysisAdd BLAST22
Topological domaini237 – 282CytoplasmicSequence analysisAdd BLAST46

Keywords - Cellular componenti

Cytoplasmic vesicle, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
363

Open Targets

More...
OpenTargetsi
ENSG00000086159

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA24924

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q13520, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
AQP6

Domain mapping of disease mutations (DMDM)

More...
DMDMi
212276421

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000639551 – 282Aquaporin-6Add BLAST282

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q13520

PeptideAtlas

More...
PeptideAtlasi
Q13520

PRoteomics IDEntifications database

More...
PRIDEi
Q13520

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
59516

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q13520

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q13520

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000086159, Expressed in cortex of kidney and 143 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q13520, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q13520, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000086159, Tissue enriched (kidney)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Q13520
With#Exp.IntAct
ABCG1 - isoform 4 [P45844-4]3EBI-13059134,EBI-8584087
ABHD16A [O95870]3EBI-13059134,EBI-348517
ACSL5 [Q9ULC5]3EBI-13059134,EBI-2876927
ADGRE2 [Q9UHX3]3EBI-13059134,EBI-11277970
ADIPOQ [Q15848]3EBI-13059134,EBI-10827839
AGMO [Q6ZNB7]3EBI-13059134,EBI-18509181
AGPAT3 [Q9NRZ7]3EBI-13059134,EBI-2803601
AGPAT4 [Q9NRZ5]3EBI-13059134,EBI-1754287
AGTRAP - isoform 2 [Q6RW13-2]3EBI-13059134,EBI-11522760
AIG1 - isoform 2 [Q9NVV5-2]3EBI-13059134,EBI-11957045
ALOX5AP [P20292]3EBI-13059134,EBI-3904621
ANKRD46 - isoform 1 [Q86W74-2]3EBI-13059134,EBI-12109402
AOC2 [O75106]3EBI-13059134,EBI-17685278
APOA2 [P02652]3EBI-13059134,EBI-1171525
AQP1 [P29972]3EBI-13059134,EBI-745213
ARL6IP1 [Q15041]3EBI-13059134,EBI-714543
ARL6IP6 [Q8N6S5]3EBI-13059134,EBI-2808844
ARV1 [Q9H2C2]3EBI-13059134,EBI-11724186
ATP13A1 - isoform C [Q9HD20-3]3EBI-13059134,EBI-12069500
ATP6V0C [P27449]3EBI-13059134,EBI-721179
BET1 [O15155]3EBI-13059134,EBI-749204
BMP10 [O95393]3EBI-13059134,EBI-3922513
BRICD5 - isoform 2 [Q6PL45-2]3EBI-13059134,EBI-12244618
BSG - isoform 2 [P35613-2]3EBI-13059134,EBI-11037868
BTN2A2 [Q8WVV5]3EBI-13059134,EBI-8648738
C16orf58 [Q96GQ5]3EBI-13059134,EBI-8636004
C2CD2L [O14523]3EBI-13059134,EBI-12822627
C4orf3 - isoform 2 [Q8WVX3-2]3EBI-13059134,EBI-12003442
C5 [P01031]3EBI-13059134,EBI-8558308
C5orf46 [Q6UWT4]3EBI-13059134,EBI-11986083
CCDC167 [Q9P0B6]3EBI-13059134,EBI-9083477
CCL22 [O00626]3EBI-13059134,EBI-3907871
CCL4L2 [Q8NHW4]3EBI-13059134,EBI-10271156
CD68 [P34810]3EBI-13059134,EBI-2826276
CD81 [P60033]3EBI-13059134,EBI-712921
CDIPT [O14735]3EBI-13059134,EBI-358858
CDW52 [Q6IBD0]3EBI-13059134,EBI-12011352
CGREF1 [A0A4W8VYG7]3EBI-13059134,EBI-23781855
CLDN19 - isoform 2 [Q8N6F1-2]3EBI-13059134,EBI-12256978
CLDN4 [O14493]3EBI-13059134,EBI-9316372
CLDND2 [Q8NHS1]3EBI-13059134,EBI-11959453
CMTM3 [Q96MX0]3EBI-13059134,EBI-7247651
CMTM5 - isoform 2 [Q96DZ9-2]3EBI-13059134,EBI-11522780
CMTM7 [Q96FZ5]3EBI-13059134,EBI-2807956
CNIH1 [O95406]3EBI-13059134,EBI-12172273
CNIH3 [Q8TBE1]3EBI-13059134,EBI-12208021
CORIN [Q9Y5Q5]3EBI-13059134,EBI-17876114
COX20 [Q5RI15]3EBI-13059134,EBI-2834035
CTXN3 [Q4LDR2]3EBI-13059134,EBI-12019274
CXCL9 [Q07325]3EBI-13059134,EBI-3911467
CXorf66 [Q5JRM2]3EBI-13059134,EBI-12823659
CYB561 [P49447]3EBI-13059134,EBI-8646596
CYB561A3 [Q8NBI2]3EBI-13059134,EBI-10269179
CYB561D1 [Q8N8Q1]3EBI-13059134,EBI-12873482
CYB5B [O43169]3EBI-13059134,EBI-1058710
CYB5R3 [P00387]3EBI-13059134,EBI-1046040
CYBC1 [Q9BQA9]3EBI-13059134,EBI-2680384
CYP4F2 [P78329]3EBI-13059134,EBI-1752413
CYP4F22 [Q6NT55]3EBI-13059134,EBI-17509525
DEFB103B [P81534]3EBI-13059134,EBI-12074168
DEFB108B [Q8NET1]3EBI-13059134,EBI-13346443
DEFB127 [Q9H1M4]3EBI-13059134,EBI-10305240
DERL1 [Q9BUN8]3EBI-13059134,EBI-398977
DGAT2L6 [Q6ZPD8]3EBI-13059134,EBI-12831978
DHRSX [Q8N5I4]3EBI-13059134,EBI-3923585
DNAJC30 [Q96LL9]3EBI-13059134,EBI-8639143
EBP [Q15125]3EBI-13059134,EBI-3915253
EFNA5 [P52803]3EBI-13059134,EBI-1753674
EMC6 [Q9BV81]3EBI-13059134,EBI-2820492
EMP1 [P54849]3EBI-13059134,EBI-4319440
EMP3 [P54852]3EBI-13059134,EBI-3907816
ERG28 [Q9UKR5]3EBI-13059134,EBI-711490
ERMP1 [Q7Z2K6]3EBI-13059134,EBI-10976398
FA2H [Q7L5A8]3EBI-13059134,EBI-11337888
FAM177A1 - isoform 2 [Q8N128-2]3EBI-13059134,EBI-12201693
FAXDC2 [Q96IV6]3EBI-13059134,EBI-12142299
FDFT1 [P37268]3EBI-13059134,EBI-714550
FUNDC2 [Q9BWH2]3EBI-13059134,EBI-714482
FXYD3 - isoform 3 [Q14802-3]3EBI-13059134,EBI-12175685
FXYD6 [Q9H0Q3]3EBI-13059134,EBI-713304
GAST [P01350]3EBI-13059134,EBI-3436637
GIMAP1 [Q8WWP7]3EBI-13059134,EBI-11991950
GIMAP5 [Q96F15]3EBI-13059134,EBI-6166686
GJB2 [P29033]3EBI-13059134,EBI-3905204
GKN1 [Q9NS71]3EBI-13059134,EBI-3933251
GOLT1A [Q6ZVE7]3EBI-13059134,EBI-17231387
GOSR2 [O14653]3EBI-13059134,EBI-4401517
GPR151 [Q8TDV0]3EBI-13059134,EBI-11955647
GPR152 [Q8TDT2]3EBI-13059134,EBI-13345167
GPR25 [O00155]3EBI-13059134,EBI-10178951
GRM2 [Q14416]3EBI-13059134,EBI-10232876
GYPC [P04921]3EBI-13059134,EBI-7797098
HMOX1 [P09601]3EBI-13059134,EBI-2806151
HMOX2 [P30519]3EBI-13059134,EBI-712096
HSD3B1 [P14060]3EBI-13059134,EBI-17426018
HTATIP2 - isoform 3 [Q9BUP3-3]3EBI-13059134,EBI-12937691
ICMT [O60725]3EBI-13059134,EBI-11721771
IFITM3 [Q01628]3EBI-13059134,EBI-7932862
IFNGR1 [P15260]3EBI-13059134,EBI-1030755
IGFBP5 [P24593]3EBI-13059134,EBI-720480
INSIG1 [O15503]3EBI-13059134,EBI-6252425
INSIG2 [Q9Y5U4]3EBI-13059134,EBI-8503746
ITGAM [P11215]3EBI-13059134,EBI-2568251
JAGN1 [Q8N5M9]3EBI-13059134,EBI-10266796
JPH1 [Q9HDC5]3EBI-13059134,EBI-465137
KCNK1 [O00180]3EBI-13059134,EBI-3914675
LEMD1 [Q68G75]3EBI-13059134,EBI-12268900
LEPROT [O15243]3EBI-13059134,EBI-15672507
LHFPL5 [Q8TAF8]3EBI-13059134,EBI-2820517
LNPEP - isoform 2 [Q9UIQ6-2]3EBI-13059134,EBI-12133176
LPAR3 [Q9UBY5]3EBI-13059134,EBI-12033434
LSS [P48449]3EBI-13059134,EBI-3930711
LY6D [Q14210]3EBI-13059134,EBI-1965225
MAL [P21145]3EBI-13059134,EBI-3932027
MAL2 [Q969L2]3EBI-13059134,EBI-944295
MALL [Q13021]3EBI-13059134,EBI-750078
MARCHF2 [Q9P0N8]3EBI-13059134,EBI-10317612
MARCHF5 [Q9NX47]3EBI-13059134,EBI-2341610
MFF - isoform 5 [Q9GZY8-5]3EBI-13059134,EBI-11956541
MFSD3 [Q96ES6]3EBI-13059134,EBI-745345
MFSD5 [Q6N075]3EBI-13059134,EBI-3920969
MGAM [O43451]3EBI-13059134,EBI-2829774
MGLL [A0A0C4DFN3]3EBI-13059134,EBI-12866138
MMP14 [P50281]3EBI-13059134,EBI-992788
MS4A1 [P11836]3EBI-13059134,EBI-2808234
MS4A13 [Q5J8X5]3EBI-13059134,EBI-12070086
MYADML2 [A6NDP7]3EBI-13059134,EBI-17641390
NEU1 [Q99519]3EBI-13059134,EBI-721517
NINJ1 [Q92982]3EBI-13059134,EBI-2802124
NINJ2 [Q9NZG7]3EBI-13059134,EBI-10317425
NKG7 [Q16617]3EBI-13059134,EBI-3919611
NRAC [Q8N912]3EBI-13059134,EBI-12051377
NRM [Q8IXM6]3EBI-13059134,EBI-10262547
ORMDL1 [Q9P0S3]3EBI-13059134,EBI-1054848
ORMDL2 [Q53FV1]3EBI-13059134,EBI-11075081
ORMDL3 [Q8N138]3EBI-13059134,EBI-721750
OTULINL [Q9NUU6]3EBI-13059134,EBI-6916492
PAEP [P09466]3EBI-13059134,EBI-465167
PDZK1IP1 [Q13113]3EBI-13059134,EBI-716063
PEMT - isoform 2 [Q9UBM1-2]3EBI-13059134,EBI-17513590
PEX11G [Q96HA9]3EBI-13059134,EBI-17284886
PEX16 [Q9Y5Y5]3EBI-13059134,EBI-981985
PIGF [Q07326]3EBI-13059134,EBI-17180304
PLLP [Q9Y342]3EBI-13059134,EBI-3919291
PLP1 - isoform DM-20 [P60201-2]3EBI-13059134,EBI-12188331
PLPP6 [Q8IY26]3EBI-13059134,EBI-11721828
PPGB [Q59EV6]3EBI-13059134,EBI-14210385
PRAF2 [O60831]3EBI-13059134,EBI-2506064
PRB1 [A5D903]3EBI-13059134,EBI-10173935
PRRT2 [Q7Z6L0]3EBI-13059134,EBI-722696
PTPN1 [P18031]3EBI-13059134,EBI-968788
PTPN9 [P43378]3EBI-13059134,EBI-742898
RAB18 [Q9NP72]3EBI-13059134,EBI-722247
RFT1 [Q96AA3]3EBI-13059134,EBI-6269616
RHD - isoform 2 [Q02161-2]3EBI-13059134,EBI-17249212
RPRM [Q9NS64]3EBI-13059134,EBI-1052363
RTP2 [Q5QGT7]3EBI-13059134,EBI-10244780
SACM1L [Q9NTJ5]3EBI-13059134,EBI-3917235
SCAMP4 [Q969E2]3EBI-13059134,EBI-4403649
SCAMP5 [Q8TAC9]3EBI-13059134,EBI-2695784
SCD [O00767]3EBI-13059134,EBI-2684237
SCGB1A1 [P11684]3EBI-13059134,EBI-7797649
SEC22A [Q96IW7]3EBI-13059134,EBI-8652744
SEC22B [O75396]3EBI-13059134,EBI-1058865
SEC61G [P60059]3EBI-13059134,EBI-4402709
SELENOK [Q9Y6D0]3EBI-13059134,EBI-9679163
SERF1B [O75920]3EBI-13059134,EBI-2115181
SERP1 [Q9Y6X1]3EBI-13059134,EBI-10329948
SERP2 [Q8N6R1]3EBI-13059134,EBI-749270
SFRP4 [Q6FHJ7]3EBI-13059134,EBI-2854879
SFT2D1 [Q8WV19]3EBI-13059134,EBI-2854842
SFT2D2 [O95562]3EBI-13059134,EBI-4402330
SFXN1 [Q9H9B4]3EBI-13059134,EBI-355861
SFXN2 [Q96NB2]3EBI-13059134,EBI-6381136
SFXN3 [A0A1P0AYU5]3EBI-13059134,EBI-14193895
SFXN5 [Q8TD22]3EBI-13059134,EBI-17274136
SLC16A12 [Q6ZSM3]3EBI-13059134,EBI-17460560
SLC16A13 [Q7RTY0]3EBI-13059134,EBI-12243266
SLC25A46 [Q96AG3]3EBI-13059134,EBI-10281975
SLC30A2 [Q9BRI3]3EBI-13059134,EBI-8644112
SLC30A8 [Q8IWU4]3EBI-13059134,EBI-10262251
SLC35A1 [P78382]3EBI-13059134,EBI-12870360
SLC35B1 [P78383]3EBI-13059134,EBI-12147661
SLC35B2 [Q8TB61]3EBI-13059134,EBI-1054782
SLC35B4 [Q969S0]3EBI-13059134,EBI-10281213
SLC35E4 [Q6ICL7]3EBI-13059134,EBI-12867720
SLC35F1 [Q5T1Q4]3EBI-13059134,EBI-13365456
SLC35F6 [Q8N357]3EBI-13059134,EBI-713484
SLC35G2 [Q8TBE7]3EBI-13059134,EBI-727304
SLC38A1 [Q9H2H9]3EBI-13059134,EBI-9978441
SLC39A2 [Q9NP94]3EBI-13059134,EBI-12898013
SLC39A7 [Q92504]3EBI-13059134,EBI-1051105
SLC39A9 [Q9NUM3]3EBI-13059134,EBI-2823239
SLC41A1 [Q8IVJ1]3EBI-13059134,EBI-12266234
SLC41A2 [Q96JW4]3EBI-13059134,EBI-10290130
SLC52A1 [Q9NWF4]3EBI-13059134,EBI-12904614
SLC66A1 - isoform 3 [Q6ZP29-3]3EBI-13059134,EBI-12889586
SLC66A2 [Q8N2U9]3EBI-13059134,EBI-3907610
SLC7A1 [P30825]3EBI-13059134,EBI-4289564
SLC7A8 [Q9UHI5]3EBI-13059134,EBI-13292283
SLCO3A1 - isoform 2 [Q9UIG8-2]3EBI-13059134,EBI-13041931
SMAGP [Q0VAQ4]3EBI-13059134,EBI-10226799
SMCO4 [Q9NRQ5]3EBI-13059134,EBI-8640191
SMIM1 [B2RUZ4]3EBI-13059134,EBI-12188413
SNORC [Q6UX34]3EBI-13059134,EBI-11957067
ST6GAL2 - isoform 2 [Q96JF0-2]3EBI-13059134,EBI-12908338
STARD3 [Q14849]3EBI-13059134,EBI-9819324
STATH [P02808]3EBI-13059134,EBI-738687
STRIT1 [P0DN84]3EBI-13059134,EBI-12200293
STX12 [Q86Y82]3EBI-13059134,EBI-2691717
STX1B [P61266]3EBI-13059134,EBI-9071709
STX3 [Q13277]3EBI-13059134,EBI-1394295
STX5 [Q13190]3EBI-13059134,EBI-714206
STX6 [O43752]3EBI-13059134,EBI-2695795
STX7 [O15400]3EBI-13059134,EBI-3221827
SYNDIG1 [Q9H7V2]3EBI-13059134,EBI-726331
SYNGR1 - isoform 1B [O43759-2]3EBI-13059134,EBI-12187159
SYNJ2BP [P57105]3EBI-13059134,EBI-1049004
TAP1 [Q03518]3EBI-13059134,EBI-747259
TBC1D20 [Q96BZ9]3EBI-13059134,EBI-9254454
TFRC [P02786]3EBI-13059134,EBI-355727
THBD [P07204]3EBI-13059134,EBI-941422
THSD7A [Q9UPZ6]3EBI-13059134,EBI-310962
THSD7B [C9JKN6]3EBI-13059134,EBI-17192156
TIMM23 [O14925]3EBI-13059134,EBI-1047996
TLCD1 [Q96CP7]3EBI-13059134,EBI-11337932
TMEM100 [Q9NV29]3EBI-13059134,EBI-8644968
TMEM107 [Q6UX40]3EBI-13059134,EBI-12845616
TMEM115 [Q12893]3EBI-13059134,EBI-8633987
TMEM120A [Q9BXJ8]3EBI-13059134,EBI-727322
TMEM120B [A0PK00]3EBI-13059134,EBI-10171534
TMEM128 - isoform 2 [Q5BJH2-2]3EBI-13059134,EBI-10694905
TMEM140 [Q9NV12]3EBI-13059134,EBI-2844246
TMEM143 [Q96AN5]3EBI-13059134,EBI-13342951
TMEM144 [Q7Z5S9]3EBI-13059134,EBI-12876358
TMEM14A [Q9Y6G1]3EBI-13059134,EBI-2800360
TMEM167B [Q9NRX6]3EBI-13059134,EBI-17684533
TMEM189-UBE2V1 [I3L0A0]3EBI-13059134,EBI-12213001
TMEM19 [Q96HH6]3EBI-13059134,EBI-741829
TMEM199 [Q8N511]3EBI-13059134,EBI-10265825
TMEM203 [Q969S6]3EBI-13059134,EBI-12274070
TMEM218 [A2RU14]3EBI-13059134,EBI-10173151
TMEM222 [Q9H0R3]3EBI-13059134,EBI-347385
TMEM229B [Q8NBD8]3EBI-13059134,EBI-12195227
TMEM234 [Q8WY98]3EBI-13059134,EBI-8642211
TMEM239 - isoform 2 [Q8WW34-2]3EBI-13059134,EBI-11528917
TMEM242 [Q9NWH2]3EBI-13059134,EBI-10315004
TMEM243 [Q9BU79]3EBI-13059134,EBI-12887458
TMEM254 [Q8TBM7]3EBI-13059134,EBI-11956809
TMEM262 [E9PQX1]3EBI-13059134,EBI-17180389
TMEM42 [Q69YG0]3EBI-13059134,EBI-12038591
TMEM50A [O95807]3EBI-13059134,EBI-12903814
TMEM51 [Q9NW97]3EBI-13059134,EBI-726044
TMEM60 [Q9H2L4]3EBI-13059134,EBI-2852148
TMEM65 [Q6PI78]3EBI-13059134,EBI-6656213
TMEM69 [Q5SWH9]3EBI-13059134,EBI-17963363
TMEM74 [Q96NL1]3EBI-13059134,EBI-10292091
TMEM86B [Q8N661]3EBI-13059134,EBI-2548832
TMEM97 [Q5BJF2]3EBI-13059134,EBI-12111910
TMUB2 [Q71RG4]3EBI-13059134,EBI-2820477
TMX2 [Q9Y320]3EBI-13059134,EBI-6447886
TNFRSF10C [O14798]3EBI-13059134,EBI-717441
TOMM22 [Q9NS69]3EBI-13059134,EBI-1047508
TOMM6 [Q96B49]3EBI-13059134,EBI-10826510
TPRG1 [Q6ZUI0]3EBI-13059134,EBI-17249488
TREX1 - isoform 1 [Q9NSU2-1]3EBI-13059134,EBI-16746122
TSPO2 [Q5TGU0]3EBI-13059134,EBI-12195249
TTMP [Q5BVD1]3EBI-13059134,EBI-10243654
UBE2J2 [Q8N2K1]3EBI-13059134,EBI-2340110
UBTD2 [Q8WUN7]3EBI-13059134,EBI-12867288
UBXN8 [O00124]3EBI-13059134,EBI-1993850
UNC50 [Q53HI1]3EBI-13059134,EBI-7601760
UNC93A - isoform 2 [Q86WB7-2]3EBI-13059134,EBI-13356252
USE1 [Q9NZ43]3EBI-13059134,EBI-742842
VAMP1 - isoform 2 [P23763-3]3EBI-13059134,EBI-12097582
VAMP2 [P63027]3EBI-13059134,EBI-520113
VAMP3 [Q15836]3EBI-13059134,EBI-722343
VAMP4 [O75379]3EBI-13059134,EBI-744953
VAMP5 [O95183]3EBI-13059134,EBI-10191195
VAPA [Q9P0L0]3EBI-13059134,EBI-1059156
VAPB [O95292]3EBI-13059134,EBI-1188298
VKORC1L1 [Q8N0U8]3EBI-13059134,EBI-11337915
VMA21 [Q3ZAQ7]3EBI-13059134,EBI-1055364
VRK2 [Q86Y07]3EBI-13059134,EBI-1207615
VSTM1 - isoform 3 [Q6UX27-3]3EBI-13059134,EBI-12190699
VTI1B [Q9UEU0]3EBI-13059134,EBI-723716
WFS1 [O76024]3EBI-13059134,EBI-720609
YIF1A [O95070]3EBI-13059134,EBI-2799703
YIPF1 [Q9Y548]3EBI-13059134,EBI-7850136
YIPF2 [Q9BWQ6]3EBI-13059134,EBI-751204
YIPF4 [Q9BSR8]3EBI-13059134,EBI-751253
YIPF6 [Q96EC8]3EBI-13059134,EBI-751210
ZDHHC21 [Q8IVQ6]3EBI-13059134,EBI-2849773
ZDHHC24 [Q6UX98]3EBI-13059134,EBI-10254561
ZNF587 [Q96SQ5]3EBI-13059134,EBI-6427977
A0A087WZY13EBI-13059134,EBI-13387614

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
Q13520, 296 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000477688

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q13520, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q13520

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi82 – 84NPA 13
Motifi196 – 198NPA 23

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0223, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000161949

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_020019_3_3_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q13520

KEGG Orthology (KO)

More...
KOi
K09868

Identification of Orthologs from Complete Genome Data

More...
OMAi
WTAISKA

Database of Orthologous Groups

More...
OrthoDBi
1152704at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q13520

TreeFam database of animal gene trees

More...
TreeFami
TF312940

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00333, MIP, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.1080.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR023271, Aquaporin-like
IPR023254, Aquaporin_6
IPR034294, Aquaporin_transptr
IPR000425, MIP
IPR022357, MIP_CS

The PANTHER Classification System

More...
PANTHERi
PTHR19139, PTHR19139, 1 hit
PTHR19139:SF113, PTHR19139:SF113, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00230, MIP, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR02018, AQUAPORIN6
PR00783, MINTRINSICP

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF81338, SSF81338, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00861, MIP, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00221, MIP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q13520-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDAVEPGGRG WASMLACRLW KAISRALFAE FLATGLYVFF GVGSVMRWPT
60 70 80 90 100
ALPSVLQIAI TFNLVTAMAV QVTWKASGAH ANPAVTLAFL VGSHISLPRA
110 120 130 140 150
VAYVAAQLVG ATVGAALLYG VMPGDIRETL GINVVRNSVS TGQAVAVELL
160 170 180 190 200
LTLQLVLCVF ASTDSRQTSG SPATMIGISV ALGHLIGIHF TGCSMNPARS
210 220 230 240 250
FGPAIIIGKF TVHWVFWVGP LMGALLASLI YNFVLFPDTK TLAQRLAILT
260 270 280
GTVEVGTGAG AGAEPLKKES QPGSGAVEME SV
Length:282
Mass (Da):29,370
Last modified:November 4, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBDA1B3DFCA5C685E
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8VW87F8VW87_HUMAN
Aquaporin-6
AQP6
108Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q9NSV5Q9NSV5_HUMAN
Aquaporin-6
AQP6 DKFZp434D2030
163Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti4 – 5VE → EV in AAB41566 (PubMed:8812490).Curated2
Sequence conflicti76A → T in AAB41566 (PubMed:8812490).Curated1
Sequence conflicti180V → W in AAB41566 (PubMed:8812490).Curated1
Sequence conflicti189H → L in AAB41566 (PubMed:8812490).Curated1
Sequence conflicti260G → R in AAB41566 (PubMed:8812490).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_047233234V → I. Corresponds to variant dbSNP:rs17124220Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U48408 mRNA Translation: AAB41566.1
AC025154 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS31798.1

NCBI Reference Sequences

More...
RefSeqi
NP_001643.2, NM_001652.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000315520; ENSP00000320247; ENSG00000086159
ENST00000615425; ENSP00000477688; ENSG00000086159

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
363

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:363

UCSC genome browser

More...
UCSCi
uc001rvr.2, human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U48408 mRNA Translation: AAB41566.1
AC025154 Genomic DNA No translation available.
CCDSiCCDS31798.1
RefSeqiNP_001643.2, NM_001652.3

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1S6Emodel-A1-282[»]
SMRiQ13520
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

IntActiQ13520, 296 interactors
STRINGi9606.ENSP00000477688

Protein family/group databases

TCDBi1.A.8.8.4, the major intrinsic protein (mip) family

PTM databases

iPTMnetiQ13520
PhosphoSitePlusiQ13520

Polymorphism and mutation databases

BioMutaiAQP6
DMDMi212276421

Proteomic databases

PaxDbiQ13520
PeptideAtlasiQ13520
PRIDEiQ13520
ProteomicsDBi59516

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
26099, 79 antibodies

Genome annotation databases

EnsembliENST00000315520; ENSP00000320247; ENSG00000086159
ENST00000615425; ENSP00000477688; ENSG00000086159
GeneIDi363
KEGGihsa:363
UCSCiuc001rvr.2, human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
363
DisGeNETi363
EuPathDBiHostDB:ENSG00000086159.12

GeneCards: human genes, protein and diseases

More...
GeneCardsi
AQP6
HGNCiHGNC:639, AQP6
HPAiENSG00000086159, Tissue enriched (kidney)
MIMi601383, gene
neXtProtiNX_Q13520
OpenTargetsiENSG00000086159
PharmGKBiPA24924

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0223, Eukaryota
GeneTreeiENSGT00940000161949
HOGENOMiCLU_020019_3_3_1
InParanoidiQ13520
KOiK09868
OMAiWTAISKA
OrthoDBi1152704at2759
PhylomeDBiQ13520
TreeFamiTF312940

Enzyme and pathway databases

PathwayCommonsiQ13520
ReactomeiR-HSA-432047, Passive transport by Aquaporins

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
363, 1 hit in 870 CRISPR screens

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
AQP6

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
363
PharosiQ13520, Tbio

Protein Ontology

More...
PROi
PR:Q13520
RNActiQ13520, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000086159, Expressed in cortex of kidney and 143 other tissues
ExpressionAtlasiQ13520, baseline and differential
GenevisibleiQ13520, HS

Family and domain databases

CDDicd00333, MIP, 1 hit
Gene3Di1.20.1080.10, 1 hit
InterProiView protein in InterPro
IPR023271, Aquaporin-like
IPR023254, Aquaporin_6
IPR034294, Aquaporin_transptr
IPR000425, MIP
IPR022357, MIP_CS
PANTHERiPTHR19139, PTHR19139, 1 hit
PTHR19139:SF113, PTHR19139:SF113, 1 hit
PfamiView protein in Pfam
PF00230, MIP, 1 hit
PRINTSiPR02018, AQUAPORIN6
PR00783, MINTRINSICP
SUPFAMiSSF81338, SSF81338, 1 hit
TIGRFAMsiTIGR00861, MIP, 1 hit
PROSITEiView protein in PROSITE
PS00221, MIP, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAQP6_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q13520
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 4, 2008
Last modified: August 12, 2020
This is version 165 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again