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Entry version 156 (12 Aug 2020)
Sequence version 1 (01 Nov 1997)
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Protein

Prepronociceptin

Gene

PNOC

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Ligand of the opioid receptor-like receptor OPRL1. It may act as a transmitter in the brain by modulating nociceptive and locomotor behavior. May be involved in neuronal differentiation and development.By similarity
Blocks nociceptin action in pain transmission by inhibiting nociceptin-induced hyperalgesia and allodynia.By similarity
Has potent analgesic activity.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionNeuropeptide, Neurotransmitter, Opioid peptide

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q13519

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-375276, Peptide ligand-binding receptors
R-HSA-418594, G alpha (i) signalling events

Protein family/group databases

Transport Classification Database

More...
TCDBi
1.C.89.1.3, the dynorphin channel-forming neuropeptide (dynorphin) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Prepronociceptin
Cleaved into the following 3 chains:
Alternative name(s):
Orphanin FQ
PPNOC
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PNOC
Synonyms:OFQ
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000168081.8

Human Gene Nomenclature Database

More...
HGNCi
HGNC:9163, PNOC

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
601459, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q13519

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
5368

Open Targets

More...
OpenTargetsi
ENSG00000168081

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA33485

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q13519, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PNOC

Domain mapping of disease mutations (DMDM)

More...
DMDMi
2494348

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 19Sequence analysisAdd BLAST19
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_000000832520 – 95Add BLAST76
<p>This subsection of the 'PTM / Processing' section describes the position and length of an active peptide in the mature protein.<p><a href='/help/peptide' target='_top'>More...</a></p>PeptideiPRO_000000832698 – 127NocistatinCuratedAdd BLAST30
PeptideiPRO_0000008327130 – 146NociceptinBy similarityAdd BLAST17
PeptideiPRO_0000008328149 – 165Orphanin FQ2CuratedAdd BLAST17
PropeptideiPRO_0000008329169 – 1768

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Specific enzymatic cleavages at paired basic residues probably yield other active peptides besides nociceptin.
The N-terminal domain contains 6 conserved cysteines thought to be involved in disulfide bonding and/or processing.

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q13519

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q13519

PeptideAtlas

More...
PeptideAtlasi
Q13519

PRoteomics IDEntifications database

More...
PRIDEi
Q13519

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
59515 [Q13519-1]
6832

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
Q13519-2 [Q13519-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q13519

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q13519

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Predominantly expressed in the brain and spinal cord. Also expressed and secreted by peripheral blood neutrophils following degranulation.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000168081, Expressed in tonsil and 138 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q13519, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q13519, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000168081, Tissue enhanced (blood, brain, lymphoid tissue)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
111381, 16 interactors

Protein interaction database and analysis system

More...
IntActi
Q13519, 1 interactor

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000301908

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q13519, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q13519

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502S0DD, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000183149

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_143892_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q13519

Identification of Orthologs from Complete Genome Data

More...
OMAi
DPGQSDC

Database of Orthologous Groups

More...
OrthoDBi
1486887at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q13519

TreeFam database of animal gene trees

More...
TreeFami
TF332620

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002367, Nociceptin
IPR006024, Opioid_neupept

The PANTHER Classification System

More...
PANTHERi
PTHR11438, PTHR11438, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01160, Opiods_neuropep, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01028, OPIOIDPRCRSR
PR01031, ORPHNNPRCRSR

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01252, OPIOIDS_PRECURSOR, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q13519-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKVLLCDLLL LSLFSSVFSS CQRDCLTCQE KLHPALDSFD LEVCILECEE
60 70 80 90 100
KVFPSPLWTP CTKVMARSSW QLSPAAPEHV AAALYQPRAS EMQHLRRMPR
110 120 130 140 150
VRSLFQEQEE PEPGMEEAGE MEQKQLQKRF GGFTGARKSA RKLANQKRFS
160 170
EFMRQYLVLS MQSSQRRRTL HQNGNV
Length:176
Mass (Da):20,295
Last modified:November 1, 1997 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8FC8DB4BB094CE6A
GO
Isoform 2 (identifier: Q13519-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-64: Missing.

Show »
Length:112
Mass (Da):13,047
Checksum:i633AAB7223669BD8
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E7EVP0E7EVP0_HUMAN
Prepronociceptin
PNOC
154Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0551461 – 64Missing in isoform 2. 1 PublicationAdd BLAST64

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X97370 mRNA Translation: CAA66040.1
X97367, X97368 Genomic DNA Translation: CAA66039.1
U48263 mRNA Translation: AAC50651.1
AY335948 mRNA Translation: AAP94601.1
AK301456 mRNA Translation: BAH13485.1
BT019334 mRNA Translation: AAV38141.1
CR541940 mRNA Translation: CAG46738.1
CR541965 mRNA Translation: CAG46763.1
AC021678 Genomic DNA No translation available.
CH471080 Genomic DNA Translation: EAW63526.1
CH471080 Genomic DNA Translation: EAW63527.1
BC034758 mRNA Translation: AAH34758.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS6066.1 [Q13519-1]
CCDS64862.1 [Q13519-2]

Protein sequence database of the Protein Information Resource

More...
PIRi
JC6152

NCBI Reference Sequences

More...
RefSeqi
NP_001271173.1, NM_001284244.1 [Q13519-2]
NP_006219.1, NM_006228.4 [Q13519-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000301908; ENSP00000301908; ENSG00000168081 [Q13519-1]
ENST00000522209; ENSP00000430145; ENSG00000168081 [Q13519-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
5368

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:5368

UCSC genome browser

More...
UCSCi
uc003xgp.5, human [Q13519-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X97370 mRNA Translation: CAA66040.1
X97367, X97368 Genomic DNA Translation: CAA66039.1
U48263 mRNA Translation: AAC50651.1
AY335948 mRNA Translation: AAP94601.1
AK301456 mRNA Translation: BAH13485.1
BT019334 mRNA Translation: AAV38141.1
CR541940 mRNA Translation: CAG46738.1
CR541965 mRNA Translation: CAG46763.1
AC021678 Genomic DNA No translation available.
CH471080 Genomic DNA Translation: EAW63526.1
CH471080 Genomic DNA Translation: EAW63527.1
BC034758 mRNA Translation: AAH34758.1
CCDSiCCDS6066.1 [Q13519-1]
CCDS64862.1 [Q13519-2]
PIRiJC6152
RefSeqiNP_001271173.1, NM_001284244.1 [Q13519-2]
NP_006219.1, NM_006228.4 [Q13519-1]

3D structure databases

SMRiQ13519
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi111381, 16 interactors
IntActiQ13519, 1 interactor
STRINGi9606.ENSP00000301908

Protein family/group databases

TCDBi1.C.89.1.3, the dynorphin channel-forming neuropeptide (dynorphin) family

PTM databases

iPTMnetiQ13519
PhosphoSitePlusiQ13519

Polymorphism and mutation databases

BioMutaiPNOC
DMDMi2494348

Proteomic databases

MassIVEiQ13519
PaxDbiQ13519
PeptideAtlasiQ13519
PRIDEiQ13519
ProteomicsDBi59515 [Q13519-1]
6832
TopDownProteomicsiQ13519-2 [Q13519-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
10388, 284 antibodies

The DNASU plasmid repository

More...
DNASUi
5368

Genome annotation databases

EnsembliENST00000301908; ENSP00000301908; ENSG00000168081 [Q13519-1]
ENST00000522209; ENSP00000430145; ENSG00000168081 [Q13519-2]
GeneIDi5368
KEGGihsa:5368
UCSCiuc003xgp.5, human [Q13519-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
5368
DisGeNETi5368
EuPathDBiHostDB:ENSG00000168081.8

GeneCards: human genes, protein and diseases

More...
GeneCardsi
PNOC
HGNCiHGNC:9163, PNOC
HPAiENSG00000168081, Tissue enhanced (blood, brain, lymphoid tissue)
MIMi601459, gene
neXtProtiNX_Q13519
OpenTargetsiENSG00000168081
PharmGKBiPA33485

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG502S0DD, Eukaryota
GeneTreeiENSGT00950000183149
HOGENOMiCLU_143892_0_0_1
InParanoidiQ13519
OMAiDPGQSDC
OrthoDBi1486887at2759
PhylomeDBiQ13519
TreeFamiTF332620

Enzyme and pathway databases

PathwayCommonsiQ13519
ReactomeiR-HSA-375276, Peptide ligand-binding receptors
R-HSA-418594, G alpha (i) signalling events

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
5368, 3 hits in 864 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
PNOC, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
5368
PharosiQ13519, Tbio

Protein Ontology

More...
PROi
PR:Q13519
RNActiQ13519, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000168081, Expressed in tonsil and 138 other tissues
ExpressionAtlasiQ13519, baseline and differential
GenevisibleiQ13519, HS

Family and domain databases

InterProiView protein in InterPro
IPR002367, Nociceptin
IPR006024, Opioid_neupept
PANTHERiPTHR11438, PTHR11438, 1 hit
PfamiView protein in Pfam
PF01160, Opiods_neuropep, 1 hit
PRINTSiPR01028, OPIOIDPRCRSR
PR01031, ORPHNNPRCRSR
PROSITEiView protein in PROSITE
PS01252, OPIOIDS_PRECURSOR, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPNOC_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q13519
Secondary accession number(s): B7Z749, Q6FH16
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: August 12, 2020
This is version 156 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
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