UniProtKB - Q13516 (OLIG2_HUMAN)
Protein
Oligodendrocyte transcription factor 2
Gene
OLIG2
Organism
Homo sapiens (Human)
Status
Functioni
Required for oligodendrocyte and motor neuron specification in the spinal cord, as well as for the development of somatic motor neurons in the hindbrain. Functions together with ZNF488 to promote oligodendrocyte differentiation. Cooperates with OLIG1 to establish the pMN domain of the embryonic neural tube. Antagonist of V2 interneuron and of NKX2-2-induced V3 interneuron development.By similarity
GO - Molecular functioni
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
- HMG box domain binding Source: Ensembl
- identical protein binding Source: Ensembl
- protein dimerization activity Source: InterPro
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
- sequence-specific double-stranded DNA binding Source: ARUK-UCL
GO - Biological processi
- myelination Source: Ensembl
- negative regulation of neuron differentiation Source: Ensembl
- negative regulation of transcription by RNA polymerase II Source: Ensembl
- neuron differentiation Source: GO_Central
- neuron fate commitment Source: Ensembl
- positive regulation of oligodendrocyte differentiation Source: Ensembl
- regulation of transcription by RNA polymerase II Source: GO_Central
- spinal cord motor neuron differentiation Source: Ensembl
- spinal cord oligodendrocyte cell fate specification Source: Ensembl
- thalamus development Source: Ensembl
Keywordsi
Molecular function | Developmental protein, DNA-binding |
Biological process | Transcription, Transcription regulation |
Enzyme and pathway databases
PathwayCommonsi | Q13516 |
SIGNORi | Q13516 |
Names & Taxonomyi
Protein namesi | Recommended name: Oligodendrocyte transcription factor 2Short name: Oligo2 Alternative name(s): Class B basic helix-loop-helix protein 1 Short name: bHLHb1 Class E basic helix-loop-helix protein 19 Short name: bHLHe19 Protein kinase C-binding protein 2 Protein kinase C-binding protein RACK17 |
Gene namesi | Name:OLIG2 Synonyms:BHLHB1, BHLHE19, PRKCBP2, RACK17 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000205927.4 |
HGNCi | HGNC:9398, OLIG2 |
MIMi | 606386, gene |
neXtProti | NX_Q13516 |
Subcellular locationi
Nucleus
- nuclear chromatin Source: NTNU_SB
- nucleus Source: GO_Central
Other locations
- cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
Cytoplasm, NucleusPathology & Biotechi
Involvement in diseasei
A chromosomal aberration involving OLIG2 may be a cause of a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(14;21)(q11.2;q22) with TCRA.1 Publication
Keywords - Diseasei
Proto-oncogeneOrganism-specific databases
DisGeNETi | 10215 |
OpenTargetsi | ENSG00000205927 |
PharmGKBi | PA31919 |
Miscellaneous databases
Pharosi | Q13516, Tbio |
Polymorphism and mutation databases
BioMutai | OLIG2 |
DMDMi | 22261817 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000127414 | 1 – 323 | Oligodendrocyte transcription factor 2Add BLAST | 323 |
Proteomic databases
PaxDbi | Q13516 |
PeptideAtlasi | Q13516 |
PRIDEi | Q13516 |
ProteomicsDBi | 59514 |
PTM databases
iPTMneti | Q13516 |
PhosphoSitePlusi | Q13516 |
Expressioni
Tissue specificityi
Expressed in the brain, in oligodendrocytes. Strongly expressed in oligodendrogliomas, while expression is weak to moderate in astrocytomas. Expression in glioblastomas highly variable.2 Publications
Inductioni
By SHH. Also induced by NKX6-1 in the developing spinal cord, but not in the rostral hindbrain (By similarity).By similarity
Gene expression databases
Bgeei | ENSG00000205927, Expressed in globus pallidus and 86 other tissues |
ExpressionAtlasi | Q13516, baseline and differential |
Genevisiblei | Q13516, HS |
Organism-specific databases
HPAi | ENSG00000205927, Tissue enriched (brain) |
Interactioni
Subunit structurei
Interacts with NKX2-2.
Interacts with ZNF488.
By similarityBinary interactionsi
Hide detailsQ13516
With | #Exp. | IntAct |
---|---|---|
KRTAP12-4 [P60329] | 3 | EBI-3914525,EBI-10176396 |
TXLNA [P40222] | 3 | EBI-3914525,EBI-359793 |
GO - Molecular functioni
- HMG box domain binding Source: Ensembl
- identical protein binding Source: Ensembl
- protein dimerization activity Source: InterPro
Protein-protein interaction databases
BioGRIDi | 115510, 9 interactors |
IntActi | Q13516, 3 interactors |
STRINGi | 9606.ENSP00000331040 |
Miscellaneous databases
RNActi | Q13516, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 108 – 162 | bHLHPROSITE-ProRule annotationAdd BLAST | 55 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 77 – 88 | Poly-SerAdd BLAST | 12 | |
Compositional biasi | 206 – 212 | Poly-Ala | 7 | |
Compositional biasi | 225 – 237 | Poly-AlaAdd BLAST | 13 | |
Compositional biasi | 266 – 270 | Poly-Ala | 5 | |
Compositional biasi | 273 – 280 | Poly-Gly | 8 |
Domaini
The bHLH is essential for interaction with NKX2-2.By similarity
Phylogenomic databases
eggNOGi | KOG3898, Eukaryota |
GeneTreei | ENSGT00940000161651 |
HOGENOMi | CLU_065376_1_0_1 |
InParanoidi | Q13516 |
OMAi | PVHHPIL |
OrthoDBi | 1290623at2759 |
PhylomeDBi | Q13516 |
TreeFami | TF322733 |
Family and domain databases
CDDi | cd00083, HLH, 1 hit |
Gene3Di | 4.10.280.10, 1 hit |
InterProi | View protein in InterPro IPR011598, bHLH_dom IPR036638, HLH_DNA-bd_sf IPR032658, Olig2 |
PANTHERi | PTHR19290:SF32, PTHR19290:SF32, 1 hit |
Pfami | View protein in Pfam PF00010, HLH, 1 hit |
SMARTi | View protein in SMART SM00353, HLH, 1 hit |
SUPFAMi | SSF47459, SSF47459, 1 hit |
PROSITEi | View protein in PROSITE PS50888, BHLH, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q13516-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDSDASLVSS RPSSPEPDDL FLPARSKGSS GSAFTGGTVS SSTPSDCPPE
60 70 80 90 100
LSAELRGAMG SAGAHPGDKL GGSGFKSSSS STSSSTSSAA ASSTKKDKKQ
110 120 130 140 150
MTEPELQQLR LKINSRERKR MHDLNIAMDG LREVMPYAHG PSVRKLSKIA
160 170 180 190 200
TLLLARNYIL MLTNSLEEMK RLVSEIYGGH HAGFHPSACG GLAHSAPLPA
210 220 230 240 250
ATAHPAAAAH AAHHPAVHHP ILPPAAAAAA AAAAAAAVSS ASLPGSGLPS
260 270 280 290 300
VGSIRPPHGL LKSPSAAAAA PLGGGGGGSG ASGGFQHWGG MPCPCSMCQV
310 320
PPPHHHVSAM GAGSLPRLTS DAK
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketC9J444 | C9J444_HUMAN | Oligodendrocyte transcription facto... | OLIG2 | 62 | Annotation score: |
Sequence cautioni
The sequence AAC72247 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAF61215 differs from that shown. Reason: Erroneous initiation.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 67 | G → V in AAH36245 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 150 | A → T in AAH47511 (PubMed:15489334).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U48250 mRNA Translation: AAC72247.1 Different initiation. AF221520 mRNA Translation: AAF61215.1 Different initiation. AK091462 mRNA Translation: BAG52365.1 BC034681 mRNA Translation: AAH34681.1 BC036245 mRNA Translation: AAH36245.1 BC047511 mRNA Translation: AAH47511.1 |
CCDSi | CCDS13620.1 |
PIRi | G02409 |
RefSeqi | NP_005797.1, NM_005806.3 XP_005260965.1, XM_005260908.1 |
Genome annotation databases
Ensembli | ENST00000333337; ENSP00000331040; ENSG00000205927 ENST00000382357; ENSP00000371794; ENSG00000205927 |
GeneIDi | 10215 |
KEGGi | hsa:10215 |
UCSCi | uc002yqx.3, human |
Keywords - Coding sequence diversityi
Chromosomal rearrangementSimilar proteinsi
Cross-referencesi
Web resourcesi
Atlas of Genetics and Cytogenetics in Oncology and Haematology |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U48250 mRNA Translation: AAC72247.1 Different initiation. AF221520 mRNA Translation: AAF61215.1 Different initiation. AK091462 mRNA Translation: BAG52365.1 BC034681 mRNA Translation: AAH34681.1 BC036245 mRNA Translation: AAH36245.1 BC047511 mRNA Translation: AAH47511.1 |
CCDSi | CCDS13620.1 |
PIRi | G02409 |
RefSeqi | NP_005797.1, NM_005806.3 XP_005260965.1, XM_005260908.1 |
3D structure databases
SMRi | Q13516 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 115510, 9 interactors |
IntActi | Q13516, 3 interactors |
STRINGi | 9606.ENSP00000331040 |
PTM databases
iPTMneti | Q13516 |
PhosphoSitePlusi | Q13516 |
Polymorphism and mutation databases
BioMutai | OLIG2 |
DMDMi | 22261817 |
Proteomic databases
PaxDbi | Q13516 |
PeptideAtlasi | Q13516 |
PRIDEi | Q13516 |
ProteomicsDBi | 59514 |
Protocols and materials databases
Antibodypediai | 917, 468 antibodies |
Genome annotation databases
Ensembli | ENST00000333337; ENSP00000331040; ENSG00000205927 ENST00000382357; ENSP00000371794; ENSG00000205927 |
GeneIDi | 10215 |
KEGGi | hsa:10215 |
UCSCi | uc002yqx.3, human |
Organism-specific databases
CTDi | 10215 |
DisGeNETi | 10215 |
EuPathDBi | HostDB:ENSG00000205927.4 |
GeneCardsi | OLIG2 |
HGNCi | HGNC:9398, OLIG2 |
HPAi | ENSG00000205927, Tissue enriched (brain) |
MIMi | 606386, gene |
neXtProti | NX_Q13516 |
OpenTargetsi | ENSG00000205927 |
PharmGKBi | PA31919 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3898, Eukaryota |
GeneTreei | ENSGT00940000161651 |
HOGENOMi | CLU_065376_1_0_1 |
InParanoidi | Q13516 |
OMAi | PVHHPIL |
OrthoDBi | 1290623at2759 |
PhylomeDBi | Q13516 |
TreeFami | TF322733 |
Enzyme and pathway databases
PathwayCommonsi | Q13516 |
SIGNORi | Q13516 |
Miscellaneous databases
BioGRID-ORCSi | 10215, 9 hits in 866 CRISPR screens |
GeneWikii | OLIG2 |
GenomeRNAii | 10215 |
Pharosi | Q13516, Tbio |
PROi | PR:Q13516 |
RNActi | Q13516, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000205927, Expressed in globus pallidus and 86 other tissues |
ExpressionAtlasi | Q13516, baseline and differential |
Genevisiblei | Q13516, HS |
Family and domain databases
CDDi | cd00083, HLH, 1 hit |
Gene3Di | 4.10.280.10, 1 hit |
InterProi | View protein in InterPro IPR011598, bHLH_dom IPR036638, HLH_DNA-bd_sf IPR032658, Olig2 |
PANTHERi | PTHR19290:SF32, PTHR19290:SF32, 1 hit |
Pfami | View protein in Pfam PF00010, HLH, 1 hit |
SMARTi | View protein in SMART SM00353, HLH, 1 hit |
SUPFAMi | SSF47459, SSF47459, 1 hit |
PROSITEi | View protein in PROSITE PS50888, BHLH, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | OLIG2_HUMAN | |
Accessioni | Q13516Primary (citable) accession number: Q13516 Secondary accession number(s): B3KRF3 Q9NZ14 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 30, 2000 |
Last sequence update: | August 13, 2002 | |
Last modified: | December 2, 2020 | |
This is version 167 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - Human chromosome 21
Human chromosome 21: entries, gene names and cross-references to MIM