OLIG2

Functionⁱ

Required for oligodendrocyte and motor neuron specification in the spinal cord, as well as for the development of somatic motor neurons in the hindbrain. Functions together with ZNF488 to promote oligodendrocyte differentiation. Cooperates with OLIG1 to establish the pMN domain of the embryonic neural tube. Antagonist of V2 interneuron and of NKX2-2-induced V3 interneuron development.By similarity

GO - Molecular functionⁱ

DNA binding Source: UniProtKB-KW
HMG box domain binding Source: Ensembl
protein homodimerization activity Source: Ensembl
RNA polymerase II transcription factor activity, sequence-specific DNA binding Source: NTNU_SB
transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding Source: Ensembl

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

myelination Source: Ensembl
negative regulation of neuron differentiation Source: Ensembl
negative regulation of transcription by RNA polymerase II Source: Ensembl
neuron fate commitment Source: Ensembl
positive regulation of oligodendrocyte differentiation Source: Ensembl
spinal cord motor neuron differentiation Source: Ensembl
spinal cord oligodendrocyte cell fate specification Source: Ensembl
thalamus development Source: Ensembl
transcription, DNA-templated Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Developmental protein, DNA-binding
Biological process	Transcription, Transcription regulation

Enzyme and pathway databases

SIGNORⁱ	Q13516

SIGNORⁱ

Q13516

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Oligodendrocyte transcription factor 2 Short name: Oligo2 Alternative name(s): Class B basic helix-loop-helix protein 1 Short name: bHLHb1 Class E basic helix-loop-helix protein 19 Short name: bHLHe19 Protein kinase C-binding protein 2 Protein kinase C-binding protein RACK17
Gene namesⁱ	Name:OLIG2 Synonyms:BHLHB1, BHLHE19, PRKCBP2, RACK17
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 21

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000205927.4
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:9398 OLIG2
MIMⁱ	606386 gene
neXtProtⁱ	NX_Q13516

Keywords - Cellular componentⁱ

Cytoplasm, Nucleus

Pathology & Biotechⁱ

Involvement in diseaseⁱ

A chromosomal aberration involving OLIG2 may be a cause of a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(14;21)(q11.2;q22) with TCRA.1 Publication

Keywords - Diseaseⁱ

Proto-oncogene

Organism-specific databases

DisGeNET More...DisGeNETⁱ	10215
Open Targets More...OpenTargetsⁱ	ENSG00000205927
PharmGKBⁱ	PA31919

Polymorphism and mutation databases

BioMutaⁱ	OLIG2
DMDMⁱ	22261817

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000127414	1 – 323	Oligodendrocyte transcription factor 2Add BLAST		323

Proteomic databases

EPDⁱ	Q13516
PaxDbⁱ	Q13516
PeptideAtlas More...PeptideAtlasⁱ	Q13516
PRIDEⁱ	Q13516
ProteomicsDBⁱ	59514

PTM databases

iPTMnetⁱ	Q13516
PhosphoSitePlusⁱ	Q13516

Expressionⁱ

Tissue specificityⁱ

Inductionⁱ

By SHH. Also induced by NKX6-1 in the developing spinal cord, but not in the rostral hindbrain (By similarity).By similarity

Gene expression databases

Bgeeⁱ	ENSG00000205927 Expressed in 67 organ(s), highest expression level in globus pallidus
CleanExⁱ	HS_OLIG2
ExpressionAtlasⁱ	Q13516 baseline and differential
Genevisibleⁱ	Q13516 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB019381 HPA003254

HPAⁱ

CAB019381
HPA003254

Interactionⁱ

Subunit structureⁱ

Interacts with NKX2-2. Interacts with ZNF488.By similarity

GO - Molecular functionⁱ

HMG box domain binding Source: Ensembl
protein homodimerization activity Source: Ensembl

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	115510, 3 interactors
IntActⁱ	Q13516, 3 interactors
STRINGⁱ	9606.ENSP00000331040

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q13516
SMRⁱ	Q13516
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	108 – 162	bHLHPROSITE-ProRule annotationAdd BLAST		55

Compositional bias

Feature key	Position(s)	DescriptionActions	Length
Compositional biasⁱ	77 – 88	Poly-SerAdd BLAST	12
Compositional biasⁱ	206 – 212	Poly-Ala	7
Compositional biasⁱ	225 – 237	Poly-AlaAdd BLAST	13
Compositional biasⁱ	266 – 270	Poly-Ala	5
Compositional biasⁱ	273 – 280	Poly-Gly	8

Domainⁱ

The bHLH is essential for interaction with NKX2-2.By similarity

Phylogenomic databases

eggNOGⁱ	KOG3898 Eukaryota ENOG411169H LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000063239
HOGENOMⁱ	HOG000015765
HOVERGENⁱ	HBG053370
InParanoidⁱ	Q13516
KEGG Orthology (KO) More...KOⁱ	K09085
OMAⁱ	SFQHWGG
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G129L
PhylomeDBⁱ	Q13516
TreeFamⁱ	TF322733

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00083 HLH, 1 hit
Gene3Dⁱ	4.10.280.10, 1 hit
InterProⁱ	View protein in InterPro IPR011598 bHLH_dom IPR036638 HLH_DNA-bd_sf IPR032658 Olig2
PANTHERⁱ	PTHR19290:SF32 PTHR19290:SF32, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00010 HLH, 1 hit
SMARTⁱ	View protein in SMART SM00353 HLH, 1 hit
SUPFAMⁱ	SSF47459 SSF47459, 1 hit
PROSITEⁱ	View protein in PROSITE PS50888 BHLH, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show all Align All

Q13516-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MDSDASLVSS RPSSPEPDDL FLPARSKGSS GSAFTGGTVS SSTPSDCPPE 
        60         70         80         90        100
LSAELRGAMG SAGAHPGDKL GGSGFKSSSS STSSSTSSAA ASSTKKDKKQ 
       110        120        130        140        150
MTEPELQQLR LKINSRERKR MHDLNIAMDG LREVMPYAHG PSVRKLSKIA 
       160        170        180        190        200
TLLLARNYIL MLTNSLEEMK RLVSEIYGGH HAGFHPSACG GLAHSAPLPA 
       210        220        230        240        250
ATAHPAAAAH AAHHPAVHHP ILPPAAAAAA AAAAAAAVSS ASLPGSGLPS 
       260        270        280        290        300
VGSIRPPHGL LKSPSAAAAA PLGGGGGGSG ASGGFQHWGG MPCPCSMCQV 
       310        320 
PPPHHHVSAM GAGSLPRLTS DAK

Length:323

Mass (Da):32,385

Last modified:August 13, 2002 - v2

Checksum:ⁱ0EC9223961062509

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	C9J444	C9J444_HUMAN		Oligodendrocyte transcription facto... Oligodendrocyte transcription factor 2	OLIG2	62	Annotation score:

Sequence cautionⁱ

The sequence AAC72247 differs from that shown. Reason: Erroneous initiation.Curated

The sequence AAF61215 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	67	G → V in AAH36245 (PubMed:14702039).Curated		1
Sequence conflictⁱ	150	A → T in AAH47511 (PubMed:15489334).Curated		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U48250 mRNA Translation: AAC72247.1 Different initiation. AF221520 mRNA Translation: AAF61215.1 Different initiation. AK091462 mRNA Translation: BAG52365.1 BC034681 mRNA Translation: AAH34681.1 BC036245 mRNA Translation: AAH36245.1 BC047511 mRNA Translation: AAH47511.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS13620.1
PIRⁱ	G02409
NCBI Reference Sequences More...RefSeqⁱ	NP_005797.1, NM_005806.3 XP_005260965.1, XM_005260908.1
UniGeneⁱ	Hs.176977 Hs.732068

Genome annotation databases

Ensemblⁱ	ENST00000333337; ENSP00000331040; ENSG00000205927 ENST00000382357; ENSP00000371794; ENSG00000205927
GeneIDⁱ	10215
KEGGⁱ	hsa:10215
UCSC genome browser More...UCSCⁱ	uc002yqx.3 human

Keywords - Coding sequence diversityⁱ

Chromosomal rearrangement

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q13516	OLIG2 isoform 1		PANTR		323	UniRef100_Q13516
OLIG2 isoform 1		PONAB		323
UPI0000E258C4		PANTR		426

Protein	Similar proteins		Species	Score	Length	Source
Q13516	OLIG2 isoform 1		PANTR		323	UniRef90_Q13516
OLIG2 isoform 1		PONAB		323
UPI0000E258C4		PANTR		426

Protein	Similar proteins		Species	Score	Length	Source
Q13516	OLIG2 isoform 1		PANTR		323	UniRef50_Q13516
OLIG2 isoform 1		PONAB		323
Oligodendrocyte transcription factor 2 (Fragment)		HUMAN		62
Oligodendrocyte transcription factor 2		CANLF		381
oligodendrocyte transcription factor 2		Enhydra lutris kenyoni		378
+15

Cross-referencesⁱ

Web resourcesⁱ

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U48250 mRNA Translation: AAC72247.1 Different initiation. AF221520 mRNA Translation: AAF61215.1 Different initiation. AK091462 mRNA Translation: BAG52365.1 BC034681 mRNA Translation: AAH34681.1 BC036245 mRNA Translation: AAH36245.1 BC047511 mRNA Translation: AAH47511.1
CCDSⁱ	CCDS13620.1
PIRⁱ	G02409
RefSeqⁱ	NP_005797.1, NM_005806.3 XP_005260965.1, XM_005260908.1
UniGeneⁱ	Hs.176977 Hs.732068

3D structure databases

ProteinModelPortalⁱ	Q13516
SMRⁱ	Q13516
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	115510, 3 interactors
IntActⁱ	Q13516, 3 interactors
STRINGⁱ	9606.ENSP00000331040

PTM databases

iPTMnetⁱ	Q13516
PhosphoSitePlusⁱ	Q13516

Polymorphism and mutation databases

BioMutaⁱ	OLIG2
DMDMⁱ	22261817

Proteomic databases

EPDⁱ	Q13516
PaxDbⁱ	Q13516
PeptideAtlasⁱ	Q13516
PRIDEⁱ	Q13516
ProteomicsDBⁱ	59514

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000333337; ENSP00000331040; ENSG00000205927 ENST00000382357; ENSP00000371794; ENSG00000205927
GeneIDⁱ	10215
KEGGⁱ	hsa:10215
UCSCⁱ	uc002yqx.3 human

Organism-specific databases

CTDⁱ	10215
DisGeNETⁱ	10215
EuPathDBⁱ	HostDB:ENSG00000205927.4
GeneCardsⁱ	OLIG2
H-InvDBⁱ	HIX0016071
HGNCⁱ	HGNC:9398 OLIG2
HPAⁱ	CAB019381 HPA003254
MIMⁱ	606386 gene
neXtProtⁱ	NX_Q13516
OpenTargetsⁱ	ENSG00000205927
PharmGKBⁱ	PA31919
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3898 Eukaryota ENOG411169H LUCA
GeneTreeⁱ	ENSGT00530000063239
HOGENOMⁱ	HOG000015765
HOVERGENⁱ	HBG053370
InParanoidⁱ	Q13516
KOⁱ	K09085
OMAⁱ	SFQHWGG
OrthoDBⁱ	EOG091G129L
PhylomeDBⁱ	Q13516
TreeFamⁱ	TF322733

Enzyme and pathway databases

SIGNORⁱ	Q13516

SIGNORⁱ

Q13516

Miscellaneous databases

GeneWikiⁱ	OLIG2
GenomeRNAiⁱ	10215
Protein Ontology More...PROⁱ	PR:Q13516
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000205927 Expressed in 67 organ(s), highest expression level in globus pallidus
CleanExⁱ	HS_OLIG2
ExpressionAtlasⁱ	Q13516 baseline and differential
Genevisibleⁱ	Q13516 HS

Family and domain databases

CDDⁱ	cd00083 HLH, 1 hit
Gene3Dⁱ	4.10.280.10, 1 hit
InterProⁱ	View protein in InterPro IPR011598 bHLH_dom IPR036638 HLH_DNA-bd_sf IPR032658 Olig2
PANTHERⁱ	PTHR19290:SF32 PTHR19290:SF32, 1 hit
Pfamⁱ	View protein in Pfam PF00010 HLH, 1 hit
SMARTⁱ	View protein in SMART SM00353 HLH, 1 hit
SUPFAMⁱ	SSF47459 SSF47459, 1 hit
PROSITEⁱ	View protein in PROSITE PS50888 BHLH, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	OLIG2_HUMAN
Accessionⁱ	Q13516Primary (citable) accession number: Q13516 Secondary accession number(s): B3KRF3 , Q05BP9, Q49AL3, Q86X04, Q9NZ14
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
	Last sequence update:	August 13, 2002
	Last modified:	September 12, 2018
	This is version 152 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human chromosome 21
Human chromosome 21: entries, gene names and cross-references to MIM
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

UniProtKB

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Help

UniRef

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Supporting data

UniProtKB - Q13516 (OLIG2_HUMAN)

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Oligodendrocyte transcription factor 2

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Other locations

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Keywords - Diseasei

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Compositional bias

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ