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Protein

Oligodendrocyte transcription factor 2

Gene

OLIG2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Required for oligodendrocyte and motor neuron specification in the spinal cord, as well as for the development of somatic motor neurons in the hindbrain. Functions together with ZNF488 to promote oligodendrocyte differentiation. Cooperates with OLIG1 to establish the pMN domain of the embryonic neural tube. Antagonist of V2 interneuron and of NKX2-2-induced V3 interneuron development.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

SIGNORiQ13516

Names & Taxonomyi

Protein namesi
Recommended name:
Oligodendrocyte transcription factor 2
Short name:
Oligo2
Alternative name(s):
Class B basic helix-loop-helix protein 1
Short name:
bHLHb1
Class E basic helix-loop-helix protein 19
Short name:
bHLHe19
Protein kinase C-binding protein 2
Protein kinase C-binding protein RACK17
Gene namesi
Name:OLIG2
Synonyms:BHLHB1, BHLHE19, PRKCBP2, RACK17
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 21

Organism-specific databases

EuPathDBiHostDB:ENSG00000205927.4
HGNCiHGNC:9398 OLIG2
MIMi606386 gene
neXtProtiNX_Q13516

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Involvement in diseasei

A chromosomal aberration involving OLIG2 may be a cause of a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(14;21)(q11.2;q22) with TCRA.1 Publication

Keywords - Diseasei

Proto-oncogene

Organism-specific databases

DisGeNETi10215
OpenTargetsiENSG00000205927
PharmGKBiPA31919

Polymorphism and mutation databases

BioMutaiOLIG2
DMDMi22261817

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001274141 – 323Oligodendrocyte transcription factor 2Add BLAST323

Proteomic databases

EPDiQ13516
PaxDbiQ13516
PeptideAtlasiQ13516
PRIDEiQ13516
ProteomicsDBi59514

PTM databases

iPTMnetiQ13516
PhosphoSitePlusiQ13516

Expressioni

Tissue specificityi

Expressed in the brain, in oligodendrocytes. Strongly expressed in oligodendrogliomas, while expression is weak to moderate in astrocytomas. Expression in glioblastomas highly variable.2 Publications

Inductioni

By SHH. Also induced by NKX6-1 in the developing spinal cord, but not in the rostral hindbrain (By similarity).By similarity

Gene expression databases

BgeeiENSG00000205927 Expressed in 67 organ(s), highest expression level in globus pallidus
CleanExiHS_OLIG2
ExpressionAtlasiQ13516 baseline and differential
GenevisibleiQ13516 HS

Organism-specific databases

HPAiCAB019381
HPA003254

Interactioni

Subunit structurei

Interacts with NKX2-2. Interacts with ZNF488.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi115510, 3 interactors
IntActiQ13516, 3 interactors
STRINGi9606.ENSP00000331040

Structurei

3D structure databases

ProteinModelPortaliQ13516
SMRiQ13516
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini108 – 162bHLHPROSITE-ProRule annotationAdd BLAST55

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi77 – 88Poly-SerAdd BLAST12
Compositional biasi206 – 212Poly-Ala7
Compositional biasi225 – 237Poly-AlaAdd BLAST13
Compositional biasi266 – 270Poly-Ala5
Compositional biasi273 – 280Poly-Gly8

Domaini

The bHLH is essential for interaction with NKX2-2.By similarity

Phylogenomic databases

eggNOGiKOG3898 Eukaryota
ENOG411169H LUCA
GeneTreeiENSGT00530000063239
HOGENOMiHOG000015765
HOVERGENiHBG053370
InParanoidiQ13516
KOiK09085
OMAiSFQHWGG
OrthoDBiEOG091G129L
PhylomeDBiQ13516
TreeFamiTF322733

Family and domain databases

CDDicd00083 HLH, 1 hit
Gene3Di4.10.280.10, 1 hit
InterProiView protein in InterPro
IPR011598 bHLH_dom
IPR036638 HLH_DNA-bd_sf
IPR032658 Olig2
PANTHERiPTHR19290:SF32 PTHR19290:SF32, 1 hit
PfamiView protein in Pfam
PF00010 HLH, 1 hit
SMARTiView protein in SMART
SM00353 HLH, 1 hit
SUPFAMiSSF47459 SSF47459, 1 hit
PROSITEiView protein in PROSITE
PS50888 BHLH, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q13516-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDSDASLVSS RPSSPEPDDL FLPARSKGSS GSAFTGGTVS SSTPSDCPPE
60 70 80 90 100
LSAELRGAMG SAGAHPGDKL GGSGFKSSSS STSSSTSSAA ASSTKKDKKQ
110 120 130 140 150
MTEPELQQLR LKINSRERKR MHDLNIAMDG LREVMPYAHG PSVRKLSKIA
160 170 180 190 200
TLLLARNYIL MLTNSLEEMK RLVSEIYGGH HAGFHPSACG GLAHSAPLPA
210 220 230 240 250
ATAHPAAAAH AAHHPAVHHP ILPPAAAAAA AAAAAAAVSS ASLPGSGLPS
260 270 280 290 300
VGSIRPPHGL LKSPSAAAAA PLGGGGGGSG ASGGFQHWGG MPCPCSMCQV
310 320
PPPHHHVSAM GAGSLPRLTS DAK
Length:323
Mass (Da):32,385
Last modified:August 13, 2002 - v2
Checksum:i0EC9223961062509
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9J444C9J444_HUMAN
Oligodendrocyte transcription facto...
OLIG2
62Annotation score:

Sequence cautioni

The sequence AAC72247 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAF61215 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti67G → V in AAH36245 (PubMed:14702039).Curated1
Sequence conflicti150A → T in AAH47511 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U48250 mRNA Translation: AAC72247.1 Different initiation.
AF221520 mRNA Translation: AAF61215.1 Different initiation.
AK091462 mRNA Translation: BAG52365.1
BC034681 mRNA Translation: AAH34681.1
BC036245 mRNA Translation: AAH36245.1
BC047511 mRNA Translation: AAH47511.1
CCDSiCCDS13620.1
PIRiG02409
RefSeqiNP_005797.1, NM_005806.3
XP_005260965.1, XM_005260908.1
UniGeneiHs.176977
Hs.732068

Genome annotation databases

EnsembliENST00000333337; ENSP00000331040; ENSG00000205927
ENST00000382357; ENSP00000371794; ENSG00000205927
GeneIDi10215
KEGGihsa:10215
UCSCiuc002yqx.3 human

Keywords - Coding sequence diversityi

Chromosomal rearrangement

Similar proteinsi

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U48250 mRNA Translation: AAC72247.1 Different initiation.
AF221520 mRNA Translation: AAF61215.1 Different initiation.
AK091462 mRNA Translation: BAG52365.1
BC034681 mRNA Translation: AAH34681.1
BC036245 mRNA Translation: AAH36245.1
BC047511 mRNA Translation: AAH47511.1
CCDSiCCDS13620.1
PIRiG02409
RefSeqiNP_005797.1, NM_005806.3
XP_005260965.1, XM_005260908.1
UniGeneiHs.176977
Hs.732068

3D structure databases

ProteinModelPortaliQ13516
SMRiQ13516
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115510, 3 interactors
IntActiQ13516, 3 interactors
STRINGi9606.ENSP00000331040

PTM databases

iPTMnetiQ13516
PhosphoSitePlusiQ13516

Polymorphism and mutation databases

BioMutaiOLIG2
DMDMi22261817

Proteomic databases

EPDiQ13516
PaxDbiQ13516
PeptideAtlasiQ13516
PRIDEiQ13516
ProteomicsDBi59514

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000333337; ENSP00000331040; ENSG00000205927
ENST00000382357; ENSP00000371794; ENSG00000205927
GeneIDi10215
KEGGihsa:10215
UCSCiuc002yqx.3 human

Organism-specific databases

CTDi10215
DisGeNETi10215
EuPathDBiHostDB:ENSG00000205927.4
GeneCardsiOLIG2
H-InvDBiHIX0016071
HGNCiHGNC:9398 OLIG2
HPAiCAB019381
HPA003254
MIMi606386 gene
neXtProtiNX_Q13516
OpenTargetsiENSG00000205927
PharmGKBiPA31919
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3898 Eukaryota
ENOG411169H LUCA
GeneTreeiENSGT00530000063239
HOGENOMiHOG000015765
HOVERGENiHBG053370
InParanoidiQ13516
KOiK09085
OMAiSFQHWGG
OrthoDBiEOG091G129L
PhylomeDBiQ13516
TreeFamiTF322733

Enzyme and pathway databases

SIGNORiQ13516

Miscellaneous databases

GeneWikiiOLIG2
GenomeRNAii10215
PROiPR:Q13516
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000205927 Expressed in 67 organ(s), highest expression level in globus pallidus
CleanExiHS_OLIG2
ExpressionAtlasiQ13516 baseline and differential
GenevisibleiQ13516 HS

Family and domain databases

CDDicd00083 HLH, 1 hit
Gene3Di4.10.280.10, 1 hit
InterProiView protein in InterPro
IPR011598 bHLH_dom
IPR036638 HLH_DNA-bd_sf
IPR032658 Olig2
PANTHERiPTHR19290:SF32 PTHR19290:SF32, 1 hit
PfamiView protein in Pfam
PF00010 HLH, 1 hit
SMARTiView protein in SMART
SM00353 HLH, 1 hit
SUPFAMiSSF47459 SSF47459, 1 hit
PROSITEiView protein in PROSITE
PS50888 BHLH, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiOLIG2_HUMAN
AccessioniPrimary (citable) accession number: Q13516
Secondary accession number(s): B3KRF3
, Q05BP9, Q49AL3, Q86X04, Q9NZ14
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: August 13, 2002
Last modified: September 12, 2018
This is version 152 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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