UniProtKB - Q13509 (TBB3_HUMAN)
Tubulin beta-3 chain
TUBB3
Functioni
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 140 – 146 | GTPSequence analysis | 7 |
GO - Molecular functioni
- GTPase activity Source: InterPro
- GTP binding Source: GO_Central
- netrin receptor binding Source: UniProtKB
- structural constituent of cytoskeleton Source: GO_Central
GO - Biological processi
- axon guidance Source: UniProtKB
- dorsal root ganglion development Source: UniProtKB
- microtubule-based process Source: GO_Central
- microtubule cytoskeleton organization Source: GO_Central
- mitotic cell cycle Source: GO_Central
- neuron differentiation Source: GO_Central
Keywordsi
Ligand | GTP-binding, Nucleotide-binding |
Enzyme and pathway databases
PathwayCommonsi | Q13509 |
Reactomei | R-HSA-1445148, Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-190840, Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane R-HSA-190861, Gap junction assembly R-HSA-2132295, MHC class II antigen presentation R-HSA-2467813, Separation of Sister Chromatids R-HSA-2500257, Resolution of Sister Chromatid Cohesion R-HSA-3371497, HSP90 chaperone cycle for steroid hormone receptors (SHR) R-HSA-380320, Recruitment of NuMA to mitotic centrosomes R-HSA-389957, Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-389960, Formation of tubulin folding intermediates by CCT/TriC R-HSA-389977, Post-chaperonin tubulin folding pathway R-HSA-437239, Recycling pathway of L1 R-HSA-5610787, Hedgehog 'off' state R-HSA-5617833, Cilium Assembly R-HSA-5620924, Intraflagellar transport R-HSA-5626467, RHO GTPases activate IQGAPs R-HSA-5663220, RHO GTPases Activate Formins R-HSA-6807878, COPI-mediated anterograde transport R-HSA-6811434, COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811436, COPI-independent Golgi-to-ER retrograde traffic R-HSA-68877, Mitotic Prometaphase R-HSA-8852276, The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8955332, Carboxyterminal post-translational modifications of tubulin R-HSA-9609690, HCMV Early Events R-HSA-9609736, Assembly and cell surface presentation of NMDA receptors R-HSA-9619483, Activation of AMPK downstream of NMDARs R-HSA-9646399, Aggrephagy R-HSA-9648025, EML4 and NUDC in mitotic spindle formation R-HSA-9668328, Sealing of the nuclear envelope (NE) by ESCRT-III R-HSA-983189, Kinesins |
SIGNORi | Q13509 |
Names & Taxonomyi
Protein namesi | Recommended name: Tubulin beta-3 chainAlternative name(s): Tubulin beta-4 chain Tubulin beta-III |
Gene namesi | Name:TUBB3 Synonyms:TUBB4 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000258947.6 |
HGNCi | HGNC:20772, TUBB3 |
MIMi | 602661, gene |
neXtProti | NX_Q13509 |
Subcellular locationi
Cytoskeleton
- cytoskeleton By similarity
Other locations
- lamellipodium By similarity
- filopodium By similarity
Cytoskeleton
- microtubule Source: UniProtKB
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
Nucleus
- nucleus Source: UniProtKB
Other locations
- axon Source: ARUK-UCL
- cytoplasm Source: GO_Central
- dendrite Source: ParkinsonsUK-UCL
- filopodium Source: UniProtKB
- growth cone Source: UniProtKB
- lamellipodium Source: UniProtKB
Keywords - Cellular componenti
Cell projection, Cytoplasm, Cytoskeleton, MicrotubulePathology & Biotechi
Involvement in diseasei
Fibrosis of extraocular muscles, congenital, 3A (CFEOM3A)1 Publication
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_062758 | 62 | R → Q in CFEOM3A; affects heterodimers formation; results in increased stability and reduced dynamics of microtubules. 1 PublicationCorresponds to variant dbSNP:rs864321714EnsemblClinVar. | 1 | |
Natural variantiVAR_062759 | 262 | R → C in CFEOM3A; affects heterodimers formation; affects microtubules polymerization and depolymerization rates. 1 PublicationCorresponds to variant dbSNP:rs267607162EnsemblClinVar. | 1 | |
Natural variantiVAR_062760 | 262 | R → H in CFEOM3A; severe phenotype with congenital facial weakness, congenital wrist and finger contractures; affects microtubules polymerization and depolymerization rates. 1 PublicationCorresponds to variant dbSNP:rs864321716EnsemblClinVar. | 1 | |
Natural variantiVAR_062761 | 302 | A → T in CFEOM3A; affects heterodimers formation; results in increased stability and reduced dynamics of microtubules. 1 PublicationCorresponds to variant dbSNP:rs267607163EnsemblClinVar. | 1 | |
Natural variantiVAR_062762 | 380 | R → C in CFEOM3A; affects heterodimers formation; results in increased stability and reduced dynamics of microtubules. 1 PublicationCorresponds to variant dbSNP:rs864321717EnsemblClinVar. | 1 | |
Natural variantiVAR_062763 | 410 | E → K in CFEOM3A; severe phenotype with congenital facial weakness; lower extremity weakness and sensory loss in the second to third decade of life in one patient; affects microtubules polymerization and depolymerization rates. 1 PublicationCorresponds to variant dbSNP:rs267607165EnsemblClinVar. | 1 | |
Natural variantiVAR_062764 | 417 | D → H in CFEOM3A; severe phenotype with congenital facial weakness, congenital wrist and finger contractures. 1 PublicationCorresponds to variant dbSNP:rs267607164EnsemblClinVar. | 1 | |
Natural variantiVAR_062765 | 417 | D → N in CFEOM3A; some patients with lower extremity weakness and sensory loss in the second to third decade of life; also found in patients without CFEOM3A who developed polyneuropathy. 1 PublicationCorresponds to variant dbSNP:rs267607164EnsemblClinVar. | 1 |
Cortical dysplasia, complex, with other brain malformations 1 (CDCBM1)1 Publication
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_066206 | 178 | T → M in CDCBM1; can form tubulin heterodimers that are properly incorporated into microtubules; the microtubules are less stable than wild-type. 1 PublicationCorresponds to variant dbSNP:rs747480526EnsemblClinVar. | 1 | |
Natural variantiVAR_066207 | 205 | E → K in CDCBM1; does not form tubulin heterodimers; patient fibroblasts show no major alterations in the microtubule network, but the microtubules are less stable than wild-type. 1 PublicationCorresponds to variant dbSNP:rs878853257EnsemblClinVar. | 1 | |
Natural variantiVAR_066208 | 302 | A → V in CDCBM1; does not form tubulin heterodimers. 1 PublicationCorresponds to variant dbSNP:rs878853258EnsemblClinVar. | 1 | |
Natural variantiVAR_066209 | 323 | M → V in CDCBM1; reduced heterodimers formation. 1 PublicationCorresponds to variant dbSNP:rs878853256EnsemblClinVar. | 1 |
Keywords - Diseasei
Disease mutationOrganism-specific databases
DisGeNETi | 10381 |
GeneReviewsi | TUBB3 |
MalaCardsi | TUBB3 |
MIMi | 600638, phenotype 614039, phenotype |
OpenTargetsi | ENSG00000258947 |
Orphaneti | 45358, Congenital fibrosis of extraocular muscles 300570, Cortical dysgenesis with pontocerebellar hypoplasia due to TUBB3 mutation 467166, Tubulinopathy-associated dysgyria |
PharmGKBi | PA134953867 |
Miscellaneous databases
Pharosi | Q13509, Tclin |
Chemistry databases
ChEMBLi | CHEMBL2597 |
DrugBanki | DB05147, CYT997 DB01873, Epothilone D DB04845, Ixabepilone DB03010, Patupilone DB12695, Phenethyl Isothiocyanate DB06042, ZEN-012 |
DrugCentrali | Q13509 |
GuidetoPHARMACOLOGYi | 2752 |
Polymorphism and mutation databases
BioMutai | TUBB3 |
DMDMi | 20455526 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000048250 | 1 – 450 | Tubulin beta-3 chainAdd BLAST | 450 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 172 | Phosphoserine; by CDK11 Publication | 1 | |
Modified residuei | 438 | 5-glutamyl polyglutamateBy similarity | 1 | |
Modified residuei | 444 | PhosphoserineBy similarity | 1 |
Post-translational modificationi
Keywords - PTMi
Isopeptide bond, PhosphoproteinProteomic databases
EPDi | Q13509 |
jPOSTi | Q13509 |
MassIVEi | Q13509 |
MaxQBi | Q13509 |
PaxDbi | Q13509 |
PeptideAtlasi | Q13509 |
PRIDEi | Q13509 |
ProteomicsDBi | 1874 59510 [Q13509-1] |
TopDownProteomicsi | Q13509-1 [Q13509-1] |
2D gel databases
OGPi | Q13509 |
PTM databases
iPTMneti | Q13509 |
MetOSitei | Q13509 |
PhosphoSitePlusi | Q13509 |
SwissPalmi | Q13509 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000258947, Expressed in cortical plate and 112 other tissues |
ExpressionAtlasi | Q13509, baseline and differential |
Genevisiblei | Q13509, HS |
Organism-specific databases
HPAi | ENSG00000258947, Tissue enriched (brain) |
Interactioni
Subunit structurei
Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
Interacts with UNC5C (via cytoplasmic domain); this interaction is decreased by NTN1/Netrin-1 (PubMed:28483977).
1 PublicationBinary interactionsi
Hide detailsQ13509
With | #Exp. | IntAct |
---|---|---|
TERF1 [P54274] | 2 | EBI-350989,EBI-710997 |
TUBA1B [P68363] | 3 | EBI-350989,EBI-487083 |
UNC5C [O95185] | 2 | EBI-350989,EBI-11343380 |
GO - Molecular functioni
- netrin receptor binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 115654, 320 interactors |
CORUMi | Q13509 |
DIPi | DIP-31505N |
IntActi | Q13509, 263 interactors |
MINTi | Q13509 |
STRINGi | 9606.ENSP00000320295 |
Miscellaneous databases
RNActi | Q13509, protein |
Structurei
Secondary structure
3D structure databases
SMRi | Q13509 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domaini
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG1375, Eukaryota |
GeneTreei | ENSGT00940000159115 |
HOGENOMi | CLU_015718_0_0_1 |
InParanoidi | Q13509 |
PhylomeDBi | Q13509 |
TreeFami | TF300298 |
Family and domain databases
Gene3Di | 1.10.287.600, 1 hit 3.30.1330.20, 1 hit 3.40.50.1440, 1 hit |
InterProi | View protein in InterPro IPR013838, Beta-tubulin_BS IPR002453, Beta_tubulin IPR008280, Tub_FtsZ_C IPR000217, Tubulin IPR018316, Tubulin/FtsZ_2-layer-sand-dom IPR037103, Tubulin/FtsZ_C_sf IPR036525, Tubulin/FtsZ_GTPase_sf IPR023123, Tubulin_C IPR017975, Tubulin_CS IPR003008, Tubulin_FtsZ_GTPase |
PANTHERi | PTHR11588, PTHR11588, 1 hit |
Pfami | View protein in Pfam PF00091, Tubulin, 1 hit PF03953, Tubulin_C, 1 hit |
PRINTSi | PR01163, BETATUBULIN PR01161, TUBULIN |
SMARTi | View protein in SMART SM00864, Tubulin, 1 hit SM00865, Tubulin_C, 1 hit |
SUPFAMi | SSF52490, SSF52490, 1 hit SSF55307, SSF55307, 1 hit |
PROSITEi | View protein in PROSITE PS00227, TUBULIN, 1 hit PS00228, TUBULIN_B_AUTOREG, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 9 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MREIVHIQAG QCGNQIGAKF WEVISDEHGI DPSGNYVGDS DLQLERISVY
60 70 80 90 100
YNEASSHKYV PRAILVDLEP GTMDSVRSGA FGHLFRPDNF IFGQSGAGNN
110 120 130 140 150
WAKGHYTEGA ELVDSVLDVV RKECENCDCL QGFQLTHSLG GGTGSGMGTL
160 170 180 190 200
LISKVREEYP DRIMNTFSVV PSPKVSDTVV EPYNATLSIH QLVENTDETY
210 220 230 240 250
CIDNEALYDI CFRTLKLATP TYGDLNHLVS ATMSGVTTSL RFPGQLNADL
260 270 280 290 300
RKLAVNMVPF PRLHFFMPGF APLTARGSQQ YRALTVPELT QQMFDAKNMM
310 320 330 340 350
AACDPRHGRY LTVATVFRGR MSMKEVDEQM LAIQSKNSSY FVEWIPNNVK
360 370 380 390 400
VAVCDIPPRG LKMSSTFIGN STAIQELFKR ISEQFTAMFR RKAFLHWYTG
410 420 430 440 450
EGMDEMEFTE AESNMNDLVS EYQQYQDATA EEEGEMYEDD EEESEAQGPK
Computationally mapped potential isoform sequencesi
There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketG3V2A3 | G3V2A3_HUMAN | Tubulin beta chain | TUBB3 | 189 | Annotation score: | ||
G3V2N6 | G3V2N6_HUMAN | HCG1983504, isoform CRA_d | TUBB3 hCG_1983504 | 164 | Annotation score: | ||
G3V3R4 | G3V3R4_HUMAN | HCG1983504, isoform CRA_c | TUBB3 hCG_1983504 | 148 | Annotation score: | ||
G3V5W4 | G3V5W4_HUMAN | Tubulin beta-3 chain | TUBB3 | 97 | Annotation score: | ||
G3V2R8 | G3V2R8_HUMAN | HCG1983504, isoform CRA_e | TUBB3 hCG_1983504 | 118 | Annotation score: | ||
G3V542 | G3V542_HUMAN | Tubulin beta-3 chain | TUBB3 | 46 | Annotation score: | ||
G3V3W7 | G3V3W7_HUMAN | Tubulin beta-3 chain | TUBB3 | 87 | Annotation score: | ||
G3V3J6 | G3V3J6_HUMAN | HCG1983504, isoform CRA_b | TUBB3 hCG_1983504 | 55 | Annotation score: | ||
G3V4U2 | G3V4U2_HUMAN | Tubulin beta-3 chain | TUBB3 | 51 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 275 | A → R in AAC52035 (PubMed:9473684).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_062758 | 62 | R → Q in CFEOM3A; affects heterodimers formation; results in increased stability and reduced dynamics of microtubules. 1 PublicationCorresponds to variant dbSNP:rs864321714EnsemblClinVar. | 1 | |
Natural variantiVAR_066206 | 178 | T → M in CDCBM1; can form tubulin heterodimers that are properly incorporated into microtubules; the microtubules are less stable than wild-type. 1 PublicationCorresponds to variant dbSNP:rs747480526EnsemblClinVar. | 1 | |
Natural variantiVAR_066207 | 205 | E → K in CDCBM1; does not form tubulin heterodimers; patient fibroblasts show no major alterations in the microtubule network, but the microtubules are less stable than wild-type. 1 PublicationCorresponds to variant dbSNP:rs878853257EnsemblClinVar. | 1 | |
Natural variantiVAR_062759 | 262 | R → C in CFEOM3A; affects heterodimers formation; affects microtubules polymerization and depolymerization rates. 1 PublicationCorresponds to variant dbSNP:rs267607162EnsemblClinVar. | 1 | |
Natural variantiVAR_062760 | 262 | R → H in CFEOM3A; severe phenotype with congenital facial weakness, congenital wrist and finger contractures; affects microtubules polymerization and depolymerization rates. 1 PublicationCorresponds to variant dbSNP:rs864321716EnsemblClinVar. | 1 | |
Natural variantiVAR_062761 | 302 | A → T in CFEOM3A; affects heterodimers formation; results in increased stability and reduced dynamics of microtubules. 1 PublicationCorresponds to variant dbSNP:rs267607163EnsemblClinVar. | 1 | |
Natural variantiVAR_066208 | 302 | A → V in CDCBM1; does not form tubulin heterodimers. 1 PublicationCorresponds to variant dbSNP:rs878853258EnsemblClinVar. | 1 | |
Natural variantiVAR_066209 | 323 | M → V in CDCBM1; reduced heterodimers formation. 1 PublicationCorresponds to variant dbSNP:rs878853256EnsemblClinVar. | 1 | |
Natural variantiVAR_062762 | 380 | R → C in CFEOM3A; affects heterodimers formation; results in increased stability and reduced dynamics of microtubules. 1 PublicationCorresponds to variant dbSNP:rs864321717EnsemblClinVar. | 1 | |
Natural variantiVAR_062763 | 410 | E → K in CFEOM3A; severe phenotype with congenital facial weakness; lower extremity weakness and sensory loss in the second to third decade of life in one patient; affects microtubules polymerization and depolymerization rates. 1 PublicationCorresponds to variant dbSNP:rs267607165EnsemblClinVar. | 1 | |
Natural variantiVAR_062764 | 417 | D → H in CFEOM3A; severe phenotype with congenital facial weakness, congenital wrist and finger contractures. 1 PublicationCorresponds to variant dbSNP:rs267607164EnsemblClinVar. | 1 | |
Natural variantiVAR_062765 | 417 | D → N in CFEOM3A; some patients with lower extremity weakness and sensory loss in the second to third decade of life; also found in patients without CFEOM3A who developed polyneuropathy. 1 PublicationCorresponds to variant dbSNP:rs267607164EnsemblClinVar. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_054659 | 1 – 72 | Missing in isoform 2. 1 PublicationAdd BLAST | 72 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U47634 mRNA Translation: AAC52035.1 AF427491 mRNA Translation: AAL28094.1 AK122757 mRNA Translation: BAG53710.1 AK292219 mRNA Translation: BAF84908.1 AC092143 Genomic DNA No translation available. CH471184 Genomic DNA Translation: EAW66674.1 BC000748 mRNA Translation: AAH00748.1 BC003021 mRNA Translation: AAH03021.2 |
CCDSi | CCDS10988.1 [Q13509-1] CCDS56012.1 [Q13509-2] |
RefSeqi | NP_001184110.1, NM_001197181.1 [Q13509-2] NP_006077.2, NM_006086.3 [Q13509-1] |
Genome annotation databases
Ensembli | ENST00000315491; ENSP00000320295; ENSG00000258947 [Q13509-1] ENST00000554444; ENSP00000451617; ENSG00000258947 [Q13509-2] |
GeneIDi | 10381 |
KEGGi | hsa:10381 |
UCSCi | uc002fph.2, human [Q13509-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U47634 mRNA Translation: AAC52035.1 AF427491 mRNA Translation: AAL28094.1 AK122757 mRNA Translation: BAG53710.1 AK292219 mRNA Translation: BAF84908.1 AC092143 Genomic DNA No translation available. CH471184 Genomic DNA Translation: EAW66674.1 BC000748 mRNA Translation: AAH00748.1 BC003021 mRNA Translation: AAH03021.2 |
CCDSi | CCDS10988.1 [Q13509-1] CCDS56012.1 [Q13509-2] |
RefSeqi | NP_001184110.1, NM_001197181.1 [Q13509-2] NP_006077.2, NM_006086.3 [Q13509-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
5IJ0 | electron microscopy | 3.80 | B | 1-426 | [»] | |
5IJ9 | electron microscopy | 3.70 | B | 1-426 | [»] | |
5JCO | electron microscopy | 4.00 | C/D/I/J/K/L | 1-426 | [»] | |
6E7B | electron microscopy | 3.50 | B | 1-426 | [»] | |
6S8L | X-ray | 1.80 | B | 1-450 | [»] | |
6WSL | electron microscopy | 3.10 | B/F | 1-450 | [»] | |
SMRi | Q13509 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 115654, 320 interactors |
CORUMi | Q13509 |
DIPi | DIP-31505N |
IntActi | Q13509, 263 interactors |
MINTi | Q13509 |
STRINGi | 9606.ENSP00000320295 |
Chemistry databases
ChEMBLi | CHEMBL2597 |
DrugBanki | DB05147, CYT997 DB01873, Epothilone D DB04845, Ixabepilone DB03010, Patupilone DB12695, Phenethyl Isothiocyanate DB06042, ZEN-012 |
DrugCentrali | Q13509 |
GuidetoPHARMACOLOGYi | 2752 |
PTM databases
iPTMneti | Q13509 |
MetOSitei | Q13509 |
PhosphoSitePlusi | Q13509 |
SwissPalmi | Q13509 |
Polymorphism and mutation databases
BioMutai | TUBB3 |
DMDMi | 20455526 |
2D gel databases
OGPi | Q13509 |
Proteomic databases
EPDi | Q13509 |
jPOSTi | Q13509 |
MassIVEi | Q13509 |
MaxQBi | Q13509 |
PaxDbi | Q13509 |
PeptideAtlasi | Q13509 |
PRIDEi | Q13509 |
ProteomicsDBi | 1874 59510 [Q13509-1] |
TopDownProteomicsi | Q13509-1 [Q13509-1] |
Protocols and materials databases
Antibodypediai | 54822, 1034 antibodies |
DNASUi | 10381 |
Genome annotation databases
Ensembli | ENST00000315491; ENSP00000320295; ENSG00000258947 [Q13509-1] ENST00000554444; ENSP00000451617; ENSG00000258947 [Q13509-2] |
GeneIDi | 10381 |
KEGGi | hsa:10381 |
UCSCi | uc002fph.2, human [Q13509-1] |
Organism-specific databases
CTDi | 10381 |
DisGeNETi | 10381 |
EuPathDBi | HostDB:ENSG00000258947.6 |
GeneCardsi | TUBB3 |
GeneReviewsi | TUBB3 |
HGNCi | HGNC:20772, TUBB3 |
HPAi | ENSG00000258947, Tissue enriched (brain) |
MalaCardsi | TUBB3 |
MIMi | 600638, phenotype 602661, gene 614039, phenotype |
neXtProti | NX_Q13509 |
OpenTargetsi | ENSG00000258947 |
Orphaneti | 45358, Congenital fibrosis of extraocular muscles 300570, Cortical dysgenesis with pontocerebellar hypoplasia due to TUBB3 mutation 467166, Tubulinopathy-associated dysgyria |
PharmGKBi | PA134953867 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1375, Eukaryota |
GeneTreei | ENSGT00940000159115 |
HOGENOMi | CLU_015718_0_0_1 |
InParanoidi | Q13509 |
PhylomeDBi | Q13509 |
TreeFami | TF300298 |
Enzyme and pathway databases
PathwayCommonsi | Q13509 |
Reactomei | R-HSA-1445148, Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-190840, Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane R-HSA-190861, Gap junction assembly R-HSA-2132295, MHC class II antigen presentation R-HSA-2467813, Separation of Sister Chromatids R-HSA-2500257, Resolution of Sister Chromatid Cohesion R-HSA-3371497, HSP90 chaperone cycle for steroid hormone receptors (SHR) R-HSA-380320, Recruitment of NuMA to mitotic centrosomes R-HSA-389957, Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-389960, Formation of tubulin folding intermediates by CCT/TriC R-HSA-389977, Post-chaperonin tubulin folding pathway R-HSA-437239, Recycling pathway of L1 R-HSA-5610787, Hedgehog 'off' state R-HSA-5617833, Cilium Assembly R-HSA-5620924, Intraflagellar transport R-HSA-5626467, RHO GTPases activate IQGAPs R-HSA-5663220, RHO GTPases Activate Formins R-HSA-6807878, COPI-mediated anterograde transport R-HSA-6811434, COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811436, COPI-independent Golgi-to-ER retrograde traffic R-HSA-68877, Mitotic Prometaphase R-HSA-8852276, The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8955332, Carboxyterminal post-translational modifications of tubulin R-HSA-9609690, HCMV Early Events R-HSA-9609736, Assembly and cell surface presentation of NMDA receptors R-HSA-9619483, Activation of AMPK downstream of NMDARs R-HSA-9646399, Aggrephagy R-HSA-9648025, EML4 and NUDC in mitotic spindle formation R-HSA-9668328, Sealing of the nuclear envelope (NE) by ESCRT-III R-HSA-983189, Kinesins |
SIGNORi | Q13509 |
Miscellaneous databases
BioGRID-ORCSi | 10381, 86 hits in 846 CRISPR screens |
ChiTaRSi | TUBB3, human |
GeneWikii | TUBB3 |
GenomeRNAii | 10381 |
Pharosi | Q13509, Tclin |
PROi | PR:Q13509 |
RNActi | Q13509, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000258947, Expressed in cortical plate and 112 other tissues |
ExpressionAtlasi | Q13509, baseline and differential |
Genevisiblei | Q13509, HS |
Family and domain databases
Gene3Di | 1.10.287.600, 1 hit 3.30.1330.20, 1 hit 3.40.50.1440, 1 hit |
InterProi | View protein in InterPro IPR013838, Beta-tubulin_BS IPR002453, Beta_tubulin IPR008280, Tub_FtsZ_C IPR000217, Tubulin IPR018316, Tubulin/FtsZ_2-layer-sand-dom IPR037103, Tubulin/FtsZ_C_sf IPR036525, Tubulin/FtsZ_GTPase_sf IPR023123, Tubulin_C IPR017975, Tubulin_CS IPR003008, Tubulin_FtsZ_GTPase |
PANTHERi | PTHR11588, PTHR11588, 1 hit |
Pfami | View protein in Pfam PF00091, Tubulin, 1 hit PF03953, Tubulin_C, 1 hit |
PRINTSi | PR01163, BETATUBULIN PR01161, TUBULIN |
SMARTi | View protein in SMART SM00864, Tubulin, 1 hit SM00865, Tubulin_C, 1 hit |
SUPFAMi | SSF52490, SSF52490, 1 hit SSF55307, SSF55307, 1 hit |
PROSITEi | View protein in PROSITE PS00227, TUBULIN, 1 hit PS00228, TUBULIN_B_AUTOREG, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | TBB3_HUMAN | |
Accessioni | Q13509Primary (citable) accession number: Q13509 Secondary accession number(s): A8K854, Q9BTZ0, Q9BW10 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 15, 1998 |
Last sequence update: | May 2, 2002 | |
Last modified: | December 2, 2020 | |
This is version 201 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human chromosome 16
Human chromosome 16: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations