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Protein

Short transient receptor potential channel 3

Gene

TRPC3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C, and by inositol 1,4,5-triphosphate receptors (ITPR) with bound IP3. May also be activated by internal calcium store depletion.4 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • calcium channel activity Source: Reactome
  • inositol 1,4,5 trisphosphate binding Source: BHF-UCL
  • store-operated calcium channel activity Source: GO_Central

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionCalcium channel, Ion channel
Biological processCalcium transport, Ion transport, Transport
LigandCalcium

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-114508 Effects of PIP2 hydrolysis
R-HSA-139853 Elevation of cytosolic Ca2+ levels
R-HSA-3295583 TRP channels
R-HSA-418890 Role of second messengers in netrin-1 signaling
R-HSA-9022699 MECP2 regulates neuronal receptors and channels

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q13507

Protein family/group databases

Transport Classification Database

More...
TCDBi
1.A.4.1.4 the transient receptor potential ca(2+) channel (trp-cc) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Short transient receptor potential channel 3
Short name:
TrpC3
Alternative name(s):
Transient receptor protein 3
Short name:
TRP-3
Short name:
hTrp-3
Short name:
hTrp3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TRPC3
Synonyms:TRP3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000138741.10

Human Gene Nomenclature Database

More...
HGNCi
HGNC:12335 TRPC3

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
602345 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q13507

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 369CytoplasmicSequence analysisAdd BLAST369
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei370 – 390HelicalSequence analysisAdd BLAST21
Topological domaini391 – 418ExtracellularSequence analysisAdd BLAST28
Transmembranei419 – 439HelicalSequence analysisAdd BLAST21
Topological domaini440 – 451CytoplasmicSequence analysisAdd BLAST12
Transmembranei452 – 472HelicalSequence analysisAdd BLAST21
Topological domaini473 – 523ExtracellularSequence analysisAdd BLAST51
Transmembranei524 – 544HelicalSequence analysisAdd BLAST21
Topological domaini545 – 567CytoplasmicSequence analysisAdd BLAST23
Transmembranei568 – 588HelicalSequence analysisAdd BLAST21
Topological domaini589 – 637ExtracellularSequence analysisAdd BLAST49
Transmembranei638 – 658HelicalSequence analysisAdd BLAST21
Topological domaini659 – 836CytoplasmicSequence analysisAdd BLAST178

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Spinocerebellar ataxia 41 (SCA41)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of spinocerebellar ataxia, a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord.
See also OMIM:616410
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_073835762R → H in SCA41; toxic gain of function effect. 1 Publication1

Keywords - Diseasei

Disease mutation, Neurodegeneration, Spinocerebellar ataxia

Organism-specific databases

DisGeNET

More...
DisGeNETi
7222

MalaCards human disease database

More...
MalaCardsi
TRPC3
MIMi616410 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000138741

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
458798 Spinocerebellar ataxia type 41

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA37008

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL2417348

IUPHAR/BPS Guide to PHARMACOLOGY

More...
GuidetoPHARMACOLOGYi
488

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TRPC3

Domain mapping of disease mutations (DMDM)

More...
DMDMi
332278239

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002153101 – 836Short transient receptor potential channel 3Add BLAST836

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi404N-linked (GlcNAc...) asparagine1 Publication1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q13507

PeptideAtlas

More...
PeptideAtlasi
Q13507

PRoteomics IDEntifications database

More...
PRIDEi
Q13507

ProteomicsDB human proteome resource

More...
ProteomicsDBi
59504
59505 [Q13507-2]
59506 [Q13507-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q13507

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q13507

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed predominantly in brain and at much lower levels in ovary, colon, small intestine, lung, prostate, placenta and testis.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000138741 Expressed in 112 organ(s), highest expression level in buccal mucosa cell

CleanEx database of gene expression profiles

More...
CleanExi
HS_TRPC3

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q13507 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q13507 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA037969

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with TRPC1, ITPR1, ITPR3, MX1 and RNF24. Interacts with JPH2; the interaction is involved in maintaining Ca2+ homeostasis in skeletal muscle and is mediated by JPH2 'Ser-165' phosphorylation.5 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
113073, 14 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
Q13507

Database of interacting proteins

More...
DIPi
DIP-34311N

Protein interaction database and analysis system

More...
IntActi
Q13507, 8 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000368966

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
Q13507

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1836
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q13507

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q13507

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati26 – 55ANK 1Add BLAST30
Repeati61 – 90ANK 2Add BLAST30
Repeati92 – 118ANK 3Add BLAST27
Repeati147 – 176ANK 4Add BLAST30

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni765 – 785Binds to IP3R3Add BLAST21

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

ANK repeat, Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3609 Eukaryota
ENOG410XQ0Y LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000153138

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000020590

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG068337

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q13507

KEGG Orthology (KO)

More...
KOi
K04966

Identification of Orthologs from Complete Genome Data

More...
OMAi
TVTDYPK

Database of Orthologous Groups

More...
OrthoDBi
EOG091G01FB

TreeFam database of animal gene trees

More...
TreeFami
TF313147

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00204 ANK, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.20, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR005821 Ion_trans_dom
IPR013555 TRP_dom
IPR005459 TRPC3_channel
IPR002153 TRPC_channel

The PANTHER Classification System

More...
PANTHERi
PTHR10117 PTHR10117, 1 hit
PTHR10117:SF8 PTHR10117:SF8, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12796 Ank_2, 1 hit
PF00520 Ion_trans, 1 hit
PF08344 TRP_2, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01097 TRNSRECEPTRP
PR01644 TRPCHANNEL3

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00248 ANK, 3 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48403 SSF48403, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q13507-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MREKGRRQAV RGPAFMFNDR GTSLTAEEER FLDAAEYGNI PVVRKMLEES
60 70 80 90 100
KTLNVNCVDY MGQNALQLAV GNEHLEVTEL LLKKENLARI GDALLLAISK
110 120 130 140 150
GYVRIVEAIL NHPGFAASKR LTLSPCEQEL QDDDFYAYDE DGTRFSPDIT
160 170 180 190 200
PIILAAHCQK YEVVHMLLMK GARIERPHDY FCKCGDCMEK QRHDSFSHSR
210 220 230 240 250
SRINAYKGLA SPAYLSLSSE DPVLTALELS NELAKLANIE KEFKNDYRKL
260 270 280 290 300
SMQCKDFVVG VLDLCRDSEE VEAILNGDLE SAEPLEVHRH KASLSRVKLA
310 320 330 340 350
IKYEVKKFVA HPNCQQQLLT IWYENLSGLR EQTIAIKCLV VLVVALGLPF
360 370 380 390 400
LAIGYWIAPC SRLGKILRSP FMKFVAHAAS FIIFLGLLVF NASDRFEGIT
410 420 430 440 450
TLPNITVTDY PKQIFRVKTT QFTWTEMLIM VWVLGMMWSE CKELWLEGPR
460 470 480 490 500
EYILQLWNVL DFGMLSIFIA AFTARFLAFL QATKAQQYVD SYVQESDLSE
510 520 530 540 550
VTLPPEIQYF TYARDKWLPS DPQIISEGLY AIAVVLSFSR IAYILPANES
560 570 580 590 600
FGPLQISLGR TVKDIFKFMV LFIMVFFAFM IGMFILYSYY LGAKVNAAFT
610 620 630 640 650
TVEESFKTLF WSIFGLSEVT SVVLKYDHKF IENIGYVLYG IYNVTMVVVL
660 670 680 690 700
LNMLIAMINS SYQEIEDDSD VEWKFARSKL WLSYFDDGKT LPPPFSLVPS
710 720 730 740 750
PKSFVYFIMR IVNFPKCRRR RLQKDIEMGM GNSKSRLNLF TQSNSRVFES
760 770 780 790 800
HSFNSILNQP TRYQQIMKRL IKRYVLKAQV DKENDEVNEG ELKEIKQDIS
810 820 830
SLRYELLEDK SQATEELAIL IHKLSEKLNP SMLRCE
Length:836
Mass (Da):96,009
Last modified:May 3, 2011 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4179CB3DA8B3F508
GO
Isoform 2 (identifier: Q13507-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MSTKVRKCKE...SPSLRRMTVM

Show »
Length:921
Mass (Da):105,538
Checksum:i8D7E0D144EF4BE51
GO
Isoform 3 (identifier: Q13507-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MEGSPSLRRMTVM

Show »
Length:848
Mass (Da):97,355
Checksum:i1DBC92BC941DF416
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
J3QTB0J3QTB0_HUMAN
Short transient receptor potential ...
TRPC3
793Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RC49D6RC49_HUMAN
Short transient receptor potential ...
TRPC3
276Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6R902D6R902_HUMAN
Short transient receptor potential ...
TRPC3
93Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti525I → L in BAF76424 (Ref. 4) Curated1
Sequence conflicti662Y → C in BAF76424 (Ref. 4) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_073835762R → H in SCA41; toxic gain of function effect. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0424461M → MSTKVRKCKEQARVTFPAPE EEEDEGEDEGAEPQRRRRGW RGVNGGLEPRSAPSQREPHG YCPPPFSHGPDLSMEGSPSL RRMTVM in isoform 2. 1 Publication1
Alternative sequenceiVSP_0424451M → MEGSPSLRRMTVM in isoform 3. 4 Publications1

Sequence databases

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EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
U47050 mRNA Translation: AAC51653.1
Y13758 mRNA Translation: CAA74083.1
AY865574 mRNA Translation: AAW62292.1
AB255424 mRNA Translation: BAF76424.1
AC079341 Genomic DNA No translation available.
AC108930 Genomic DNA No translation available.
BC093682 mRNA Translation: AAH93682.1
BC093684 mRNA Translation: AAH93684.1
X89068 mRNA Translation: CAA61448.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS3725.1 [Q13507-3]
CCDS47130.1 [Q13507-2]

NCBI Reference Sequences

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RefSeqi
NP_001124170.1, NM_001130698.1 [Q13507-2]
NP_003296.1, NM_003305.2 [Q13507-3]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.150981

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000264811; ENSP00000264811; ENSG00000138741 [Q13507-3]
ENST00000379645; ENSP00000368966; ENSG00000138741 [Q13507-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
7222

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:7222

UCSC genome browser

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UCSCi
uc003ief.3 human [Q13507-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U47050 mRNA Translation: AAC51653.1
Y13758 mRNA Translation: CAA74083.1
AY865574 mRNA Translation: AAW62292.1
AB255424 mRNA Translation: BAF76424.1
AC079341 Genomic DNA No translation available.
AC108930 Genomic DNA No translation available.
BC093682 mRNA Translation: AAH93682.1
BC093684 mRNA Translation: AAH93684.1
X89068 mRNA Translation: CAA61448.1
CCDSiCCDS3725.1 [Q13507-3]
CCDS47130.1 [Q13507-2]
RefSeqiNP_001124170.1, NM_001130698.1 [Q13507-2]
NP_003296.1, NM_003305.2 [Q13507-3]
UniGeneiHs.150981

3D structure databases

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Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5ZBGelectron microscopy4.36A/B/C/D1-836[»]
6CUDelectron microscopy3.30A/B/C/D1-806[»]
6D7Lelectron microscopy4.00A/B/C/D1-836[»]
6DJSelectron microscopy5.80A/B/C/D1-299[»]
ProteinModelPortaliQ13507
SMRiQ13507
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113073, 14 interactors
CORUMiQ13507
DIPiDIP-34311N
IntActiQ13507, 8 interactors
STRINGi9606.ENSP00000368966

Chemistry databases

BindingDBiQ13507
ChEMBLiCHEMBL2417348
GuidetoPHARMACOLOGYi488

Protein family/group databases

TCDBi1.A.4.1.4 the transient receptor potential ca(2+) channel (trp-cc) family

PTM databases

iPTMnetiQ13507
PhosphoSitePlusiQ13507

Polymorphism and mutation databases

BioMutaiTRPC3
DMDMi332278239

Proteomic databases

PaxDbiQ13507
PeptideAtlasiQ13507
PRIDEiQ13507
ProteomicsDBi59504
59505 [Q13507-2]
59506 [Q13507-3]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000264811; ENSP00000264811; ENSG00000138741 [Q13507-3]
ENST00000379645; ENSP00000368966; ENSG00000138741 [Q13507-2]
GeneIDi7222
KEGGihsa:7222
UCSCiuc003ief.3 human [Q13507-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
7222
DisGeNETi7222
EuPathDBiHostDB:ENSG00000138741.10

GeneCards: human genes, protein and diseases

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GeneCardsi
TRPC3
HGNCiHGNC:12335 TRPC3
HPAiHPA037969
MalaCardsiTRPC3
MIMi602345 gene
616410 phenotype
neXtProtiNX_Q13507
OpenTargetsiENSG00000138741
Orphaneti458798 Spinocerebellar ataxia type 41
PharmGKBiPA37008

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3609 Eukaryota
ENOG410XQ0Y LUCA
GeneTreeiENSGT00940000153138
HOGENOMiHOG000020590
HOVERGENiHBG068337
InParanoidiQ13507
KOiK04966
OMAiTVTDYPK
OrthoDBiEOG091G01FB
TreeFamiTF313147

Enzyme and pathway databases

ReactomeiR-HSA-114508 Effects of PIP2 hydrolysis
R-HSA-139853 Elevation of cytosolic Ca2+ levels
R-HSA-3295583 TRP channels
R-HSA-418890 Role of second messengers in netrin-1 signaling
R-HSA-9022699 MECP2 regulates neuronal receptors and channels
SIGNORiQ13507

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
TRPC3 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
TRPC3

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
7222

Protein Ontology

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PROi
PR:Q13507

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000138741 Expressed in 112 organ(s), highest expression level in buccal mucosa cell
CleanExiHS_TRPC3
ExpressionAtlasiQ13507 baseline and differential
GenevisibleiQ13507 HS

Family and domain databases

CDDicd00204 ANK, 1 hit
Gene3Di1.25.40.20, 1 hit
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR005821 Ion_trans_dom
IPR013555 TRP_dom
IPR005459 TRPC3_channel
IPR002153 TRPC_channel
PANTHERiPTHR10117 PTHR10117, 1 hit
PTHR10117:SF8 PTHR10117:SF8, 1 hit
PfamiView protein in Pfam
PF12796 Ank_2, 1 hit
PF00520 Ion_trans, 1 hit
PF08344 TRP_2, 1 hit
PRINTSiPR01097 TRNSRECEPTRP
PR01644 TRPCHANNEL3
SMARTiView protein in SMART
SM00248 ANK, 3 hits
SUPFAMiSSF48403 SSF48403, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTRPC3_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q13507
Secondary accession number(s): A7VJS1
, E9PCJ9, O00593, Q15660, Q52M35, Q5G1L5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 3, 2011
Last modified: December 5, 2018
This is version 176 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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