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UniProtKB - Q13503 (MED21_HUMAN)

Entry version 168 (07 Apr 2021)
Sequence version 1 (01 Nov 1996)
Previous versions | rss
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Protein

Mediator of RNA polymerase II transcription subunit 21

Gene

MED21

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q13503

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-1989781, PPARA activates gene expression
R-HSA-381340, Transcriptional regulation of white adipocyte differentiation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Mediator of RNA polymerase II transcription subunit 21
Alternative name(s):
Mediator complex subunit 21
RNA polymerase II holoenzyme component SRB7
Short name:
RNAPII complex component SRB7
Short name:
hSrb7
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MED21
Synonyms:SRB7, SURB7
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:11473, MED21

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		603800, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q13503

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000152944.8

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		9412

Open Targets

More...OpenTargetsi		ENSG00000152944

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA162395485

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q13503, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		MED21

Domain mapping of disease mutations (DMDM)

More...DMDMi		7531204

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000963751 – 144Mediator of RNA polymerase II transcription subunit 21Add BLAST144

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q13503

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q13503

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q13503

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q13503

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q13503

PeptideAtlas

More...PeptideAtlasi		Q13503

PRoteomics IDEntifications database

More...PRIDEi		Q13503

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		59498

Consortium for Top Down Proteomics

More...TopDownProteomicsi		Q13503

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q13503

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q13503

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000152944, Expressed in secondary oocyte and 240 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q13503, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q13503, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000152944, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with PPARG (By similarity).

Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.

Interacts with THRA in a ligand-dependent fashion.

By similarity8 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		114807, 123 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...ComplexPortali		CPX-3227, Core mediator complex

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		Q13503

Database of interacting proteins

More...DIPi		DIP-31471N

Protein interaction database and analysis system

More...IntActi		Q13503, 113 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000282892

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q13503, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q13503

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the Mediator complex subunit 21 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1510, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000014557

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_126757_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q13503

Identification of Orthologs from Complete Genome Data

More...OMAi		QAENFCN

Database of Orthologous Groups

More...OrthoDBi		1583203at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q13503

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR037212, Med7/Med21-like
IPR021384, Mediator_Med21

The PANTHER Classification System

More...PANTHERi		PTHR13381, PTHR13381, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF11221, Med21, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF140718, SSF140718, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q13503-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MADRLTQLQD AVNSLADQFC NAIGVLQQCG PPASFNNIQT AINKDQPANP 
        60         70         80         90        100
TEEYAQLFAA LIARTAKDID VLIDSLPSEE STAALQAASL YKLEEENHEA 
       110        120        130        140 
ATCLEDVVYR GDMLLEKIQS ALADIAQSQL KTRSGTHSQS LPDS
Length:144
Mass (Da):15,564
Last modified:November 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF786169620EDC126
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F5H872F5H872_HUMAN
Mediator of RNA polymerase II trans...
MED21
159Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5GZQ1F5GZQ1_HUMAN
Mediator of RNA polymerase II trans...
MED21
87Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti104L → V in AAB06944 (PubMed:8609996).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
U46837 mRNA Translation: AAA98511.1
U52960 mRNA Translation: AAB06944.1
CR456999 mRNA Translation: CAG33280.1
AK311838 mRNA Translation: BAG34780.1
CH471094 Genomic DNA Translation: EAW96545.1
BC008380 mRNA Translation: AAH08380.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS8711.1

Protein sequence database of the Protein Information Resource

More...PIRi		S68454

NCBI Reference Sequences

More...RefSeqi		NP_004255.2, NM_004264.4

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000282892; ENSP00000282892; ENSG00000152944

Database of genes from NCBI RefSeq genomes

More...GeneIDi		9412

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:9412

UCSC genome browser

More...UCSCi		uc001rhp.3, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U46837 mRNA Translation: AAA98511.1
U52960 mRNA Translation: AAB06944.1
CR456999 mRNA Translation: CAG33280.1
AK311838 mRNA Translation: BAG34780.1
CH471094 Genomic DNA Translation: EAW96545.1
BC008380 mRNA Translation: AAH08380.1
CCDSiCCDS8711.1
PIRiS68454
RefSeqiNP_004255.2, NM_004264.4

3D structure databases

SMRiQ13503
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi114807, 123 interactors
ComplexPortaliCPX-3227, Core mediator complex
CORUMiQ13503
DIPiDIP-31471N
IntActiQ13503, 113 interactors
STRINGi9606.ENSP00000282892

PTM databases

iPTMnetiQ13503
PhosphoSitePlusiQ13503

Genetic variation databases

BioMutaiMED21
DMDMi7531204

Proteomic databases

EPDiQ13503
jPOSTiQ13503
MassIVEiQ13503
MaxQBiQ13503
PaxDbiQ13503
PeptideAtlasiQ13503
PRIDEiQ13503
ProteomicsDBi59498
TopDownProteomicsiQ13503

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		1803, 167 antibodies

The DNASU plasmid repository

More...DNASUi		9412

Genome annotation databases

EnsembliENST00000282892; ENSP00000282892; ENSG00000152944
GeneIDi9412
KEGGihsa:9412
UCSCiuc001rhp.3, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		9412
DisGeNETi9412

GeneCards: human genes, protein and diseases

More...GeneCardsi		MED21
HGNCiHGNC:11473, MED21
HPAiENSG00000152944, Low tissue specificity
MIMi603800, gene
neXtProtiNX_Q13503
OpenTargetsiENSG00000152944
PharmGKBiPA162395485
VEuPathDBiHostDB:ENSG00000152944.8

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1510, Eukaryota
GeneTreeiENSGT00390000014557
HOGENOMiCLU_126757_0_0_1
InParanoidiQ13503
OMAiQAENFCN
OrthoDBi1583203at2759
PhylomeDBiQ13503

Enzyme and pathway databases

PathwayCommonsiQ13503
ReactomeiR-HSA-1989781, PPARA activates gene expression
R-HSA-381340, Transcriptional regulation of white adipocyte differentiation

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		9412, 627 hits in 1012 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		MED21, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		MED21

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		9412
PharosiQ13503, Tbio

Protein Ontology

More...PROi		PR:Q13503
RNActiQ13503, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000152944, Expressed in secondary oocyte and 240 other tissues
ExpressionAtlasiQ13503, baseline and differential
GenevisibleiQ13503, HS

Family and domain databases

InterProiView protein in InterPro
IPR037212, Med7/Med21-like
IPR021384, Mediator_Med21
PANTHERiPTHR13381, PTHR13381, 1 hit
PfamiView protein in Pfam
PF11221, Med21, 1 hit
SUPFAMiSSF140718, SSF140718, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMED21_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q13503
Secondary accession number(s): B2R4I3, Q6IB05, Q92811
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1996
Last modified: April 7, 2021
This is version 168 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families
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