UniProtKB - Q13492 (PICAL_HUMAN)
Phosphatidylinositol-binding clathrin assembly protein
PICALM
Functioni
GO - Molecular functioni
- 1-phosphatidylinositol binding Source: UniProtKB
- amyloid-beta binding Source: ARUK-UCL
- cadherin binding Source: BHF-UCL
- clathrin binding Source: UniProtKB
- clathrin heavy chain binding Source: BHF-UCL
- low-density lipoprotein particle receptor binding Source: ARUK-UCL
- phosphatidylinositol-4,5-bisphosphate binding Source: ARUK-UCL
- small GTPase binding Source: ARUK-UCL
- SNARE binding Source: UniProtKB
- tau protein binding Source: Alzheimers_University_of_Toronto
GO - Biological processi
- amyloid-beta clearance by transcytosis Source: ARUK-UCL
- axonogenesis Source: Ensembl
- clathrin coat assembly Source: BHF-UCL
- clathrin-coated pit assembly Source: UniProtKB
- clathrin-dependent endocytosis Source: Alzheimers_University_of_Toronto
- dendrite morphogenesis Source: Ensembl
- endocytosis Source: UniProtKB
- endosomal transport Source: BHF-UCL
- hemopoiesis Source: Ensembl
- iron ion homeostasis Source: Alzheimers_University_of_Toronto
- learning or memory Source: ARUK-UCL
- membrane bending Source: ARUK-UCL
- membrane organization Source: Reactome
- modulation of age-related behavioral decline Source: ARUK-UCL
- negative regulation of gene expression Source: Alzheimers_University_of_Toronto
- negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process Source: Alzheimers_University_of_Toronto
- negative regulation of protein localization to cell surface Source: ARUK-UCL
- negative regulation of protein localization to plasma membrane Source: ARUK-UCL
- negative regulation of receptor-mediated endocytosis Source: BHF-UCL
- positive regulation of amyloid-beta formation Source: Alzheimers_University_of_Toronto
- positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process Source: Alzheimers_University_of_Toronto
- positive regulation of GTPase activity Source: ARUK-UCL
- positive regulation of neuron death Source: Alzheimers_University_of_Toronto
- positive regulation of transcription, DNA-templated Source: BHF-UCL
- protein-containing complex assembly Source: ProtInc
- receptor internalization Source: BHF-UCL
- receptor-mediated endocytosis Source: UniProtKB
- regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process Source: Alzheimers_University_of_Toronto
- regulation of endocytosis Source: BHF-UCL
- regulation of protein localization Source: BHF-UCL
- regulation of vesicle size Source: ARUK-UCL
- synaptic vesicle budding from presynaptic endocytic zone membrane Source: GO_Central
- synaptic vesicle maturation Source: Alzheimers_University_of_Toronto
- vesicle budding from membrane Source: ARUK-UCL
- vesicle cargo loading Source: Alzheimers_University_of_Toronto
- vesicle-mediated transport Source: ProtInc
Keywordsi
Biological process | Endocytosis |
Enzyme and pathway databases
PathwayCommonsi | Q13492 |
Reactomei | R-HSA-432722, Golgi Associated Vesicle Biogenesis R-HSA-8856825, Cargo recognition for clathrin-mediated endocytosis R-HSA-8856828, Clathrin-mediated endocytosis |
SIGNORi | Q13492 |
Protein family/group databases
MoonDBi | Q13492, Curated |
MoonProti | Q13492 |
Names & Taxonomyi
Protein namesi | Recommended name: Phosphatidylinositol-binding clathrin assembly proteinAlternative name(s): Clathrin assembly lymphoid myeloid leukemia protein |
Gene namesi | Name:PICALM Synonyms:CALM |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:15514, PICALM |
MIMi | 603025, gene |
neXtProti | NX_Q13492 |
VEuPathDBi | HostDB:ENSG00000073921.17 |
Subcellular locationi
Plasma membrane
- Cell membrane 1 Publication
Golgi apparatus
- Golgi apparatus 1 Publication
Nucleus
- Nucleus 1 Publication
Other locations
- clathrin-coated pit 1 Publication
- clathrin-coated vesicle 1 Publication
Note: Colocalized with clathrin in the Golgi area (PubMed:10436022). Interaction with PIMREG may target PICALM to the nucleus in some cells (PubMed:16491119).2 Publications
Cytosol
- cytosol Source: Reactome
Endosome
- early endosome Source: ARUK-UCL
Golgi apparatus
- Golgi apparatus Source: UniProtKB-SubCell
Nucleus
- nucleus Source: BHF-UCL
Plasma Membrane
- clathrin-coated pit Source: UniProtKB
- extrinsic component of presynaptic endocytic zone membrane Source: GO_Central
- plasma membrane Source: UniProtKB
- postsynaptic membrane Source: BHF-UCL
- presynaptic membrane Source: BHF-UCL
Other locations
- cell surface Source: ARUK-UCL
- clathrin-coated endocytic vesicle Source: ARUK-UCL
- clathrin-coated vesicle Source: ARUK-UCL
- endosome to plasma membrane transport vesicle Source: ARUK-UCL
- intracellular membrane-bounded organelle Source: HPA
- intrinsic component of membrane Source: ARUK-UCL
- membrane Source: UniProtKB
- neurofibrillary tangle Source: Alzheimers_University_of_Toronto
- neuronal cell body Source: Alzheimers_University_of_Toronto
- perinuclear region of cytoplasm Source: Ensembl
- synaptic vesicle Source: GO_Central
- vesicle Source: Alzheimers_University_of_Toronto
Keywords - Cellular componenti
Cell membrane, Coated pit, Cytoplasmic vesicle, Golgi apparatus, Membrane, NucleusPathology & Biotechi
Involvement in diseasei
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 648 – 649 | Breakpoint for translocation to form CALM/MLLT10 fusion protein | 2 |
Keywords - Diseasei
Proto-oncogeneOrganism-specific databases
DisGeNETi | 8301 |
MalaCardsi | PICALM |
NIAGADSi | ENSG00000073921 |
OpenTargetsi | ENSG00000073921 |
Orphaneti | 99861, Precursor T-cell acute lymphoblastic leukemia |
PharmGKBi | PA33287 |
Miscellaneous databases
Pharosi | Q13492, Tbio |
Genetic variation databases
BioMutai | PICALM |
DMDMi | 116242714 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedCombined sources | |||
ChainiPRO_0000187062 | 2 – 652 | Phosphatidylinositol-binding clathrin assembly proteinAdd BLAST | 651 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylserineCombined sources | 1 | |
Modified residuei | 16 | PhosphoserineCombined sources | 1 | |
Modified residuei | 20 | PhosphoserineCombined sources | 1 | |
Cross-linki | 238 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 303 | PhosphoserineCombined sources | 1 | |
Modified residuei | 315 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | Q13492 |
jPOSTi | Q13492 |
MassIVEi | Q13492 |
MaxQBi | Q13492 |
PaxDbi | Q13492 |
PeptideAtlasi | Q13492 |
PRIDEi | Q13492 |
ProteomicsDBi | 22268 28286 59489 [Q13492-1] 59490 [Q13492-2] 59491 [Q13492-3] |
PTM databases
GlyGeni | Q13492, 4 sites, 1 O-linked glycan (4 sites) |
iPTMneti | Q13492 |
MetOSitei | Q13492 |
PhosphoSitePlusi | Q13492 |
SwissPalmi | Q13492 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000073921, Expressed in corpus callosum and 246 other tissues |
ExpressionAtlasi | Q13492, baseline and differential |
Genevisiblei | Q13492, HS |
Organism-specific databases
HPAi | ENSG00000073921, Low tissue specificity |
Interactioni
Subunit structurei
Binds to clathrin; involves primarily the C-terminal sequences, but the full-length protein is required for full binding capacity. Binds phosphatidylinositol 4,5- bisphosphate.
Interacts with PIMREG; this interaction may change the subcellular location into the nucleus (PubMed:16491119).
Interacts with AP2A1 (via its alpha-appendage domain) (PubMed:16262731).
Interacts (via N-terminus) with VAMP2; VAMP3; VAMP7 and VAMP8 (Via N-terminus) (PubMed:22118466, PubMed:21808019, PubMed:23741335).
Interacts with LC3/MAP1LC3A (PubMed:24067654).
6 PublicationsBinary interactionsi
Hide detailsQ13492
With | #Exp. | IntAct |
---|---|---|
FHL2 [Q14192] | 8 | EBI-2803688,EBI-701903 |
Isoform 3 [Q13492-3]
With | #Exp. | IntAct |
---|---|---|
ATXN1 [P54253] | 3 | EBI-11031437,EBI-930964 |
ATXN1L [P0C7T5] | 3 | EBI-11031437,EBI-8624731 |
ZC3H10 [Q96K80] | 3 | EBI-11031437,EBI-742550 |
GO - Molecular functioni
- cadherin binding Source: BHF-UCL
- clathrin binding Source: UniProtKB
- clathrin heavy chain binding Source: BHF-UCL
- low-density lipoprotein particle receptor binding Source: ARUK-UCL
- small GTPase binding Source: ARUK-UCL
- SNARE binding Source: UniProtKB
- tau protein binding Source: Alzheimers_University_of_Toronto
Protein-protein interaction databases
BioGRIDi | 113902, 132 interactors |
ELMi | Q13492 |
IntActi | Q13492, 80 interactors |
MINTi | Q13492 |
STRINGi | 9606.ENSP00000377015 |
Miscellaneous databases
RNActi | Q13492, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 14 – 145 | ENTHPROSITE-ProRule annotationAdd BLAST | 132 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 221 – 294 | Interaction with PIMREG1 PublicationAdd BLAST | 74 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG0251, Eukaryota |
GeneTreei | ENSGT00950000183068 |
HOGENOMi | CLU_014080_0_0_1 |
InParanoidi | Q13492 |
OMAi | PPQMGNV |
OrthoDBi | 1592722at2759 |
PhylomeDBi | Q13492 |
TreeFami | TF314861 |
Family and domain databases
Gene3Di | 1.20.58.150, 1 hit 1.25.40.90, 1 hit |
InterProi | View protein in InterPro IPR011417, ANTH_dom IPR014712, Clathrin_AP_dom2 IPR013809, ENTH IPR008942, ENTH_VHS IPR030412, PICALM |
PANTHERi | PTHR22951:SF16, PTHR22951:SF16, 1 hit |
Pfami | View protein in Pfam PF07651, ANTH, 1 hit |
SMARTi | View protein in SMART SM00273, ENTH, 1 hit |
SUPFAMi | SSF48464, SSF48464, 1 hit |
PROSITEi | View protein in PROSITE PS50942, ENTH, 1 hit |
s (5+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 5 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 5 described isoforms and 11 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSGQSLTDRI TAAQHSVTGS AVSKTVCKAT THEIMGPKKK HLDYLIQCTN
60 70 80 90 100
EMNVNIPQLA DSLFERTTNS SWVVVFKSLI TTHHLMVYGN ERFIQYLASR
110 120 130 140 150
NTLFNLSNFL DKSGLQGYDM STFIRRYSRY LNEKAVSYRQ VAFDFTKVKR
160 170 180 190 200
GADGVMRTMN TEKLLKTVPI IQNQMDALLD FNVNSNELTN GVINAAFMLL
210 220 230 240 250
FKDAIRLFAA YNEGIINLLE KYFDMKKNQC KEGLDIYKKF LTRMTRISEF
260 270 280 290 300
LKVAEQVGID RGDIPDLSQA PSSLLDALEQ HLASLEGKKI KDSTAASRAT
310 320 330 340 350
TLSNAVSSLA STGLSLTKVD EREKQAALEE EQARLKALKE QRLKELAKKP
360 370 380 390 400
HTSLTTAASP VSTSAGGIMT APAIDIFSTP SSSNSTSKLP NDLLDLQQPT
410 420 430 440 450
FHPSVHPMST ASQVASTWGD PFSATVDAVD DAIPSLNPFL TKSSGDVHLS
460 470 480 490 500
ISSDVSTFTT RTPTHEMFVG FTPSPVAQPH PSAGLNVDFE SVFGNKSTNV
510 520 530 540 550
IVDSGGFDEL GGLLKPTVAS QNQNLPVAKL PPSKLVSDDL DSSLANLVGN
560 570 580 590 600
LGIGNGTTKN DVNWSQPGEK KLTGGSNWQP KVAPTTAWNA ATMAPPVMAY
610 620 630 640 650
PATTPTGMIG YGIPPQMGSV PVMTQPTLIY SQPVMRPPNP FGPVSGAQIQ
FM
Computationally mapped potential isoform sequencesi
There are 11 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketH0YEF7 | H0YEF7_HUMAN | Phosphatidylinositol-binding clathr... | PICALM | 302 | Annotation score: | ||
H0YD48 | H0YD48_HUMAN | Phosphatidylinositol-binding clathr... | PICALM | 264 | Annotation score: | ||
E9PLJ8 | E9PLJ8_HUMAN | Phosphatidylinositol-binding clathr... | PICALM | 185 | Annotation score: | ||
E9PI56 | E9PI56_HUMAN | Phosphatidylinositol-binding clathr... | PICALM | 147 | Annotation score: | ||
E9PKP6 | E9PKP6_HUMAN | Phosphatidylinositol-binding clathr... | PICALM | 148 | Annotation score: | ||
H0YCY1 | H0YCY1_HUMAN | Phosphatidylinositol-binding clathr... | PICALM | 244 | Annotation score: | ||
H0YEH1 | H0YEH1_HUMAN | Phosphatidylinositol-binding clathr... | PICALM | 308 | Annotation score: | ||
H0YEY8 | H0YEY8_HUMAN | Phosphatidylinositol-binding clathr... | PICALM | 215 | Annotation score: | ||
H0YE97 | H0YE97_HUMAN | Phosphatidylinositol-binding clathr... | PICALM | 134 | Annotation score: | ||
E9PK13 | E9PK13_HUMAN | Phosphatidylinositol-binding clathr... | PICALM | 105 | Annotation score: | ||
There is more potential isoformShow all |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 132 | N → D in BAG62035 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 212 | N → H in AAB07762 (PubMed:8643484).Curated | 1 | |
Sequence conflicti | 331 | E → G in BAG62035 (PubMed:14702039).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_028191 | 158 | T → P. Corresponds to variant dbSNP:rs12800974Ensembl. | 1 | |
Natural variantiVAR_028192 | 383 | S → F. Corresponds to variant dbSNP:rs12222608Ensembl. | 1 | |
Natural variantiVAR_028193 | 578 | W → C2 PublicationsCorresponds to variant dbSNP:rs1043858Ensembl. | 1 | |
Natural variantiVAR_028194 | 579 | Q → E2 PublicationsCorresponds to variant dbSNP:rs1043859Ensembl. | 1 | |
Natural variantiVAR_028195 | 641 | F → L. Corresponds to variant dbSNP:rs556337Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_044567 | 1 – 51 | Missing in isoform 4. 1 PublicationAdd BLAST | 51 | |
Alternative sequenceiVSP_009607 | 420 – 469 | Missing in isoform 3 and isoform 4. 2 PublicationsAdd BLAST | 50 | |
Alternative sequenceiVSP_044568 | 420 – 426 | Missing in isoform 5. 1 Publication | 7 | |
Alternative sequenceiVSP_009608 | 593 | M → MNGMHFPQY in isoform 3. 1 Publication | 1 | |
Alternative sequenceiVSP_004067 | 594 – 613 | Missing in isoform 2. 1 PublicationAdd BLAST | 20 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U45976 mRNA Translation: AAB07762.1 AK300275 mRNA Translation: BAG62035.1 AB210017 mRNA Translation: BAE06099.1 Different initiation. AP000767 Genomic DNA No translation available. CH471076 Genomic DNA Translation: EAW75120.1 BC048259 mRNA Translation: AAH48259.2 BC064357 mRNA Translation: AAH64357.1 BC073961 mRNA Translation: AAH73961.1 AF060939 mRNA Translation: AAC16711.1 AF060940 mRNA Translation: AAC16712.1 |
CCDSi | CCDS31653.1 [Q13492-3] CCDS55783.1 [Q13492-4] CCDS55784.1 [Q13492-5] CCDS8272.1 [Q13492-1] |
RefSeqi | NP_001008660.1, NM_001008660.2 [Q13492-3] NP_001193875.1, NM_001206946.1 [Q13492-5] NP_001193876.1, NM_001206947.1 [Q13492-4] NP_009097.2, NM_007166.3 [Q13492-1] XP_005274388.1, XM_005274331.2 [Q13492-2] |
Genome annotation databases
Ensembli | ENST00000356360; ENSP00000348718; ENSG00000073921 [Q13492-2] ENST00000393346; ENSP00000377015; ENSG00000073921 [Q13492-1] ENST00000526033; ENSP00000433846; ENSG00000073921 [Q13492-5] ENST00000528398; ENSP00000434884; ENSG00000073921 [Q13492-4] ENST00000532317; ENSP00000436958; ENSG00000073921 [Q13492-3] |
GeneIDi | 8301 |
KEGGi | hsa:8301 |
UCSCi | uc001pbl.4, human [Q13492-1] |
Keywords - Coding sequence diversityi
Alternative splicing, Chromosomal rearrangementSimilar proteinsi
Cross-referencesi
Web resourcesi
Atlas of Genetics and Cytogenetics in Oncology and Haematology |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U45976 mRNA Translation: AAB07762.1 AK300275 mRNA Translation: BAG62035.1 AB210017 mRNA Translation: BAE06099.1 Different initiation. AP000767 Genomic DNA No translation available. CH471076 Genomic DNA Translation: EAW75120.1 BC048259 mRNA Translation: AAH48259.2 BC064357 mRNA Translation: AAH64357.1 BC073961 mRNA Translation: AAH73961.1 AF060939 mRNA Translation: AAC16711.1 AF060940 mRNA Translation: AAC16712.1 |
CCDSi | CCDS31653.1 [Q13492-3] CCDS55783.1 [Q13492-4] CCDS55784.1 [Q13492-5] CCDS8272.1 [Q13492-1] |
RefSeqi | NP_001008660.1, NM_001008660.2 [Q13492-3] NP_001193875.1, NM_001206946.1 [Q13492-5] NP_001193876.1, NM_001206947.1 [Q13492-4] NP_009097.2, NM_007166.3 [Q13492-1] XP_005274388.1, XM_005274331.2 [Q13492-2] |
3D structure databases
SMRi | Q13492 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 113902, 132 interactors |
ELMi | Q13492 |
IntActi | Q13492, 80 interactors |
MINTi | Q13492 |
STRINGi | 9606.ENSP00000377015 |
Protein family/group databases
MoonDBi | Q13492, Curated |
MoonProti | Q13492 |
PTM databases
GlyGeni | Q13492, 4 sites, 1 O-linked glycan (4 sites) |
iPTMneti | Q13492 |
MetOSitei | Q13492 |
PhosphoSitePlusi | Q13492 |
SwissPalmi | Q13492 |
Genetic variation databases
BioMutai | PICALM |
DMDMi | 116242714 |
Proteomic databases
EPDi | Q13492 |
jPOSTi | Q13492 |
MassIVEi | Q13492 |
MaxQBi | Q13492 |
PaxDbi | Q13492 |
PeptideAtlasi | Q13492 |
PRIDEi | Q13492 |
ProteomicsDBi | 22268 28286 59489 [Q13492-1] 59490 [Q13492-2] 59491 [Q13492-3] |
Protocols and materials databases
Antibodypediai | 17636, 200 antibodies |
Genome annotation databases
Ensembli | ENST00000356360; ENSP00000348718; ENSG00000073921 [Q13492-2] ENST00000393346; ENSP00000377015; ENSG00000073921 [Q13492-1] ENST00000526033; ENSP00000433846; ENSG00000073921 [Q13492-5] ENST00000528398; ENSP00000434884; ENSG00000073921 [Q13492-4] ENST00000532317; ENSP00000436958; ENSG00000073921 [Q13492-3] |
GeneIDi | 8301 |
KEGGi | hsa:8301 |
UCSCi | uc001pbl.4, human [Q13492-1] |
Organism-specific databases
CTDi | 8301 |
DisGeNETi | 8301 |
GeneCardsi | PICALM |
HGNCi | HGNC:15514, PICALM |
HPAi | ENSG00000073921, Low tissue specificity |
MalaCardsi | PICALM |
MIMi | 603025, gene |
neXtProti | NX_Q13492 |
NIAGADSi | ENSG00000073921 |
OpenTargetsi | ENSG00000073921 |
Orphaneti | 99861, Precursor T-cell acute lymphoblastic leukemia |
PharmGKBi | PA33287 |
VEuPathDBi | HostDB:ENSG00000073921.17 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0251, Eukaryota |
GeneTreei | ENSGT00950000183068 |
HOGENOMi | CLU_014080_0_0_1 |
InParanoidi | Q13492 |
OMAi | PPQMGNV |
OrthoDBi | 1592722at2759 |
PhylomeDBi | Q13492 |
TreeFami | TF314861 |
Enzyme and pathway databases
PathwayCommonsi | Q13492 |
Reactomei | R-HSA-432722, Golgi Associated Vesicle Biogenesis R-HSA-8856825, Cargo recognition for clathrin-mediated endocytosis R-HSA-8856828, Clathrin-mediated endocytosis |
SIGNORi | Q13492 |
Miscellaneous databases
BioGRID-ORCSi | 8301, 35 hits in 1001 CRISPR screens |
ChiTaRSi | PICALM, human |
GeneWikii | PICALM |
GenomeRNAii | 8301 |
Pharosi | Q13492, Tbio |
PROi | PR:Q13492 |
RNActi | Q13492, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000073921, Expressed in corpus callosum and 246 other tissues |
ExpressionAtlasi | Q13492, baseline and differential |
Genevisiblei | Q13492, HS |
Family and domain databases
Gene3Di | 1.20.58.150, 1 hit 1.25.40.90, 1 hit |
InterProi | View protein in InterPro IPR011417, ANTH_dom IPR014712, Clathrin_AP_dom2 IPR013809, ENTH IPR008942, ENTH_VHS IPR030412, PICALM |
PANTHERi | PTHR22951:SF16, PTHR22951:SF16, 1 hit |
Pfami | View protein in Pfam PF07651, ANTH, 1 hit |
SMARTi | View protein in SMART SM00273, ENTH, 1 hit |
SUPFAMi | SSF48464, SSF48464, 1 hit |
PROSITEi | View protein in PROSITE PS50942, ENTH, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | PICAL_HUMAN | |
Accessioni | Q13492Primary (citable) accession number: Q13492 Secondary accession number(s): B4DTM3 Q86XZ9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 15, 2002 |
Last sequence update: | October 17, 2006 | |
Last modified: | April 7, 2021 | |
This is version 194 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families