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UniProtKB - Q13492 (PICAL_HUMAN)

Protein

Phosphatidylinositol-binding clathrin assembly protein

Gene

PICALM

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Assembly protein recruiting clathrin and adapter protein complex 2 (AP2) to cell membranes at sites of coated-pit formation and clathrin-vesicle assembly. May be required to determine the amount of membrane to be recycled, possibly by regulating the size of the clathrin cage. Involved in AP2-dependent clathrin-mediated endocytosis at the neuromuscular junction.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • 1-phosphatidylinositol binding Source: UniProtKB
  • amyloid-beta binding Source: ARUK-UCL
  • cadherin binding Source: BHF-UCL
  • clathrin binding Source: UniProtKB
  • clathrin heavy chain binding Source: BHF-UCL
  • low-density lipoprotein particle receptor binding Source: ARUK-UCL
  • phosphatidylinositol-4,5-bisphosphate binding Source: ARUK-UCL
  • Rab GTPase binding Source: ARUK-UCL
  • tau protein binding Source: Alzheimers_University_of_Toronto
View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processEndocytosis

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-432722 Golgi Associated Vesicle Biogenesis
R-HSA-8856825 Cargo recognition for clathrin-mediated endocytosis
R-HSA-8856828 Clathrin-mediated endocytosis

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q13492

Protein family/group databases

MoonDB Database of extreme multifunctional and moonlighting proteins

More...MoonDBi		Q13492 Curated

MoonProt database of moonlighting proteins

More...MoonProti		Q13492

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Phosphatidylinositol-binding clathrin assembly protein
Alternative name(s):
Clathrin assembly lymphoid myeloid leukemia protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PICALM
Synonyms:CALM
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000073921.17

Human Gene Nomenclature Database

More...HGNCi		HGNC:15514 PICALM

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		603025 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q13492

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Coated pit, Cytoplasmic vesicle, Golgi apparatus, Membrane, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

A chromosomal aberration involving PICALM is found in diffuse histiocytic lymphomas. Translocation t(10;11)(p13;q14) with MLLT10.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei648 – 649Breakpoint for translocation to form CALM/MLLT10 fusion protein2

Keywords - Diseasei

Proto-oncogene

Organism-specific databases

DisGeNET

More...DisGeNETi		8301

MalaCards human disease database

More...MalaCardsi		PICALM

Open Targets

More...OpenTargetsi		ENSG00000073921

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		99861 Precursor T-cell acute lymphoblastic leukemia

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA33287

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		PICALM

Domain mapping of disease mutations (DMDM)

More...DMDMi		116242714

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001870622 – 652Phosphatidylinositol-binding clathrin assembly proteinAdd BLAST651

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylserineCombined sources1
Modified residuei16PhosphoserineCombined sources1
Modified residuei20PhosphoserineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki238Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei303PhosphoserineCombined sources1
Modified residuei315PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q13492

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q13492

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q13492

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q13492

PeptideAtlas

More...PeptideAtlasi		Q13492

PRoteomics IDEntifications database

More...PRIDEi		Q13492

ProteomicsDB human proteome resource

More...ProteomicsDBi		59489
59490 [Q13492-2]
59491 [Q13492-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q13492

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q13492

SwissPalm database of S-palmitoylation events

More...SwissPalmi		Q13492

Miscellaneous databases

CutDB - Proteolytic event database

More...PMAP-CutDBi		Q13492

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in all tissues examined.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000073921 Expressed in 234 organ(s), highest expression level in corpus callosum

CleanEx database of gene expression profiles

More...CleanExi		HS_PICALM

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q13492 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q13492 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		HPA019053
HPA019061

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Binds clathrin; involves primarily the C-terminal sequences, but the full-length protein is required for full binding capacity. Binds phosphatidylinositol 4,5- bisphosphate. Interacts with PIMREG; this interaction may change the subcellular location into the nucleus.2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
FHL2Q141928EBI-2803688,EBI-701903

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		113902, 103 interactors

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...ELMi		Q13492

Protein interaction database and analysis system

More...IntActi		Q13492, 61 interactors

Molecular INTeraction database

More...MINTi		Q13492

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000377015

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...ProteinModelPortali		Q13492

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q13492

Database of comparative protein structure models

More...ModBasei		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini14 – 145ENTHPROSITE-ProRule annotationAdd BLAST132

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni221 – 294Interaction with PIMREG1 PublicationAdd BLAST74

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the PICALM/SNAP91 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0251 Eukaryota
ENOG410XQ90 LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00940000154483

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		HOG000015764

The HOVERGEN Database of Homologous Vertebrate Genes

More...HOVERGENi		HBG049391

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q13492

KEGG Orthology (KO)

More...KOi		K20044

Identification of Orthologs from Complete Genome Data

More...OMAi		PTGMMAY

Database of Orthologous Groups

More...OrthoDBi		1592722at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q13492

TreeFam database of animal gene trees

More...TreeFami		TF314861

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.20.58.150, 1 hit
1.25.40.90, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR011417 ANTH_dom
IPR014712 Clathrin_AP_dom2
IPR013809 ENTH
IPR008942 ENTH_VHS
IPR030412 PICALM

The PANTHER Classification System

More...PANTHERi		PTHR22951:SF16 PTHR22951:SF16, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF07651 ANTH, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00273 ENTH, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48464 SSF48464, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50942 ENTH, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 5 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 11 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q13492-1) [UniParc]FASTAAdd to basket
Also known as: Type I

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSGQSLTDRI TAAQHSVTGS AVSKTVCKAT THEIMGPKKK HLDYLIQCTN 
        60         70         80         90        100
EMNVNIPQLA DSLFERTTNS SWVVVFKSLI TTHHLMVYGN ERFIQYLASR 
       110        120        130        140        150
NTLFNLSNFL DKSGLQGYDM STFIRRYSRY LNEKAVSYRQ VAFDFTKVKR 
       160        170        180        190        200
GADGVMRTMN TEKLLKTVPI IQNQMDALLD FNVNSNELTN GVINAAFMLL 
       210        220        230        240        250
FKDAIRLFAA YNEGIINLLE KYFDMKKNQC KEGLDIYKKF LTRMTRISEF 
       260        270        280        290        300
LKVAEQVGID RGDIPDLSQA PSSLLDALEQ HLASLEGKKI KDSTAASRAT 
       310        320        330        340        350
TLSNAVSSLA STGLSLTKVD EREKQAALEE EQARLKALKE QRLKELAKKP 
       360        370        380        390        400
HTSLTTAASP VSTSAGGIMT APAIDIFSTP SSSNSTSKLP NDLLDLQQPT 
       410        420        430        440        450
FHPSVHPMST ASQVASTWGD PFSATVDAVD DAIPSLNPFL TKSSGDVHLS 
       460        470        480        490        500
ISSDVSTFTT RTPTHEMFVG FTPSPVAQPH PSAGLNVDFE SVFGNKSTNV 
       510        520        530        540        550
IVDSGGFDEL GGLLKPTVAS QNQNLPVAKL PPSKLVSDDL DSSLANLVGN 
       560        570        580        590        600
LGIGNGTTKN DVNWSQPGEK KLTGGSNWQP KVAPTTAWNA ATMAPPVMAY 
       610        620        630        640        650
PATTPTGMIG YGIPPQMGSV PVMTQPTLIY SQPVMRPPNP FGPVSGAQIQ 

FM
Length:652
Mass (Da):70,755
Last modified:October 17, 2006 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iAC3227E9D32AFEDA
GO
Isoform 2 (identifier: Q13492-2) [UniParc]FASTAAdd to basket
Also known as: Type II

The sequence of this isoform differs from the canonical sequence as follows:
     594-613: Missing.

Show »
Length:632
Mass (Da):68,764
Checksum:iD13D4427A30EE4FD
GO
Isoform 3 (identifier: Q13492-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     420-469: Missing.
     593-593: M → MNGMHFPQY

Note: No experimental confirmation available.
Show »
Length:610
Mass (Da):66,393
Checksum:i3B0D0AEB901CF85D
GO
Isoform 4 (identifier: Q13492-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-51: Missing.
     420-469: Missing.

Note: No experimental confirmation available.
Show »
Length:551
Mass (Da):59,918
Checksum:iA39E7E594F66D57F
GO
Isoform 5 (identifier: Q13492-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     420-426: Missing.

Note: No experimental confirmation available.
Show »
Length:645
Mass (Da):70,037
Checksum:iE4F76B25065B499A
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 11 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YEF7H0YEF7_HUMAN
Phosphatidylinositol-binding clathr...
PICALM
302Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YD48H0YD48_HUMAN
Phosphatidylinositol-binding clathr...
PICALM
264Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YEH1H0YEH1_HUMAN
Phosphatidylinositol-binding clathr...
PICALM
308Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YCY1H0YCY1_HUMAN
Phosphatidylinositol-binding clathr...
PICALM
244Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PLJ8E9PLJ8_HUMAN
Phosphatidylinositol-binding clathr...
PICALM
185Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PKP6E9PKP6_HUMAN
Phosphatidylinositol-binding clathr...
PICALM
148Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PI56E9PI56_HUMAN
Phosphatidylinositol-binding clathr...
PICALM
147Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PK13E9PK13_HUMAN
Phosphatidylinositol-binding clathr...
PICALM
105Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YE97H0YE97_HUMAN
Phosphatidylinositol-binding clathr...
PICALM
134Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YEY8H0YEY8_HUMAN
Phosphatidylinositol-binding clathr...
PICALM
215Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There is more potential isoformShow all

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAE06099 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti132N → D in BAG62035 (PubMed:14702039).Curated1
Sequence conflicti212N → H in AAB07762 (PubMed:8643484).Curated1
Sequence conflicti331E → G in BAG62035 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_028191158T → P. Corresponds to variant dbSNP:rs12800974Ensembl.1
Natural variantiVAR_028192383S → F. Corresponds to variant dbSNP:rs12222608Ensembl.1
Natural variantiVAR_028193578W → C2 PublicationsCorresponds to variant dbSNP:rs1043858Ensembl.1
Natural variantiVAR_028194579Q → E2 PublicationsCorresponds to variant dbSNP:rs1043859Ensembl.1
Natural variantiVAR_028195641F → L. Corresponds to variant dbSNP:rs556337Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0445671 – 51Missing in isoform 4. 1 PublicationAdd BLAST51
Alternative sequenceiVSP_009607420 – 469Missing in isoform 3 and isoform 4. 2 PublicationsAdd BLAST50
Alternative sequenceiVSP_044568420 – 426Missing in isoform 5. 1 Publication7
Alternative sequenceiVSP_009608593M → MNGMHFPQY in isoform 3. 1 Publication1
Alternative sequenceiVSP_004067594 – 613Missing in isoform 2. 1 PublicationAdd BLAST20

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
U45976 mRNA Translation: AAB07762.1
AK300275 mRNA Translation: BAG62035.1
AB210017 mRNA Translation: BAE06099.1 Different initiation.
AP000767 Genomic DNA No translation available.
CH471076 Genomic DNA Translation: EAW75120.1
BC048259 mRNA Translation: AAH48259.2
BC064357 mRNA Translation: AAH64357.1
BC073961 mRNA Translation: AAH73961.1
AF060939 mRNA Translation: AAC16711.1
AF060940 mRNA Translation: AAC16712.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS31653.1 [Q13492-3]
CCDS55783.1 [Q13492-4]
CCDS55784.1 [Q13492-5]
CCDS8272.1 [Q13492-1]

NCBI Reference Sequences

More...RefSeqi		NP_001008660.1, NM_001008660.2 [Q13492-3]
NP_001193875.1, NM_001206946.1 [Q13492-5]
NP_001193876.1, NM_001206947.1 [Q13492-4]
NP_009097.2, NM_007166.3 [Q13492-1]
XP_005274388.1, XM_005274331.2 [Q13492-2]

UniGene gene-oriented nucleotide sequence clusters

More...UniGenei		Hs.163893

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000356360; ENSP00000348718; ENSG00000073921 [Q13492-2]
ENST00000393346; ENSP00000377015; ENSG00000073921 [Q13492-1]
ENST00000526033; ENSP00000433846; ENSG00000073921 [Q13492-5]
ENST00000528398; ENSP00000434884; ENSG00000073921 [Q13492-4]
ENST00000532317; ENSP00000436958; ENSG00000073921 [Q13492-3]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		8301

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:8301

UCSC genome browser

More...UCSCi		uc001pbl.4 human [Q13492-1]

Keywords - Coding sequence diversityi

Alternative splicing, Chromosomal rearrangement, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U45976 mRNA Translation: AAB07762.1
AK300275 mRNA Translation: BAG62035.1
AB210017 mRNA Translation: BAE06099.1 Different initiation.
AP000767 Genomic DNA No translation available.
CH471076 Genomic DNA Translation: EAW75120.1
BC048259 mRNA Translation: AAH48259.2
BC064357 mRNA Translation: AAH64357.1
BC073961 mRNA Translation: AAH73961.1
AF060939 mRNA Translation: AAC16711.1
AF060940 mRNA Translation: AAC16712.1
CCDSiCCDS31653.1 [Q13492-3]
CCDS55783.1 [Q13492-4]
CCDS55784.1 [Q13492-5]
CCDS8272.1 [Q13492-1]
RefSeqiNP_001008660.1, NM_001008660.2 [Q13492-3]
NP_001193875.1, NM_001206946.1 [Q13492-5]
NP_001193876.1, NM_001206947.1 [Q13492-4]
NP_009097.2, NM_007166.3 [Q13492-1]
XP_005274388.1, XM_005274331.2 [Q13492-2]
UniGeneiHs.163893

3D structure databases

ProteinModelPortaliQ13492
SMRiQ13492
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113902, 103 interactors
ELMiQ13492
IntActiQ13492, 61 interactors
MINTiQ13492
STRINGi9606.ENSP00000377015

Protein family/group databases

MoonDBiQ13492 Curated
MoonProtiQ13492

PTM databases

iPTMnetiQ13492
PhosphoSitePlusiQ13492
SwissPalmiQ13492

Polymorphism and mutation databases

BioMutaiPICALM
DMDMi116242714

Proteomic databases

EPDiQ13492
jPOSTiQ13492
MaxQBiQ13492
PaxDbiQ13492
PeptideAtlasiQ13492
PRIDEiQ13492
ProteomicsDBi59489
59490 [Q13492-2]
59491 [Q13492-3]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000356360; ENSP00000348718; ENSG00000073921 [Q13492-2]
ENST00000393346; ENSP00000377015; ENSG00000073921 [Q13492-1]
ENST00000526033; ENSP00000433846; ENSG00000073921 [Q13492-5]
ENST00000528398; ENSP00000434884; ENSG00000073921 [Q13492-4]
ENST00000532317; ENSP00000436958; ENSG00000073921 [Q13492-3]
GeneIDi8301
KEGGihsa:8301
UCSCiuc001pbl.4 human [Q13492-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		8301
DisGeNETi8301
EuPathDBiHostDB:ENSG00000073921.17

GeneCards: human genes, protein and diseases

More...GeneCardsi		PICALM
HGNCiHGNC:15514 PICALM
HPAiHPA019053
HPA019061
MalaCardsiPICALM
MIMi603025 gene
neXtProtiNX_Q13492
OpenTargetsiENSG00000073921
Orphaneti99861 Precursor T-cell acute lymphoblastic leukemia
PharmGKBiPA33287

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0251 Eukaryota
ENOG410XQ90 LUCA
GeneTreeiENSGT00940000154483
HOGENOMiHOG000015764
HOVERGENiHBG049391
InParanoidiQ13492
KOiK20044
OMAiPTGMMAY
OrthoDBi1592722at2759
PhylomeDBiQ13492
TreeFamiTF314861

Enzyme and pathway databases

ReactomeiR-HSA-432722 Golgi Associated Vesicle Biogenesis
R-HSA-8856825 Cargo recognition for clathrin-mediated endocytosis
R-HSA-8856828 Clathrin-mediated endocytosis
SIGNORiQ13492

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		PICALM human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		PICALM

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		8301
PMAP-CutDBiQ13492

Protein Ontology

More...PROi		PR:Q13492

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000073921 Expressed in 234 organ(s), highest expression level in corpus callosum
CleanExiHS_PICALM
ExpressionAtlasiQ13492 baseline and differential
GenevisibleiQ13492 HS

Family and domain databases

Gene3Di1.20.58.150, 1 hit
1.25.40.90, 1 hit
InterProiView protein in InterPro
IPR011417 ANTH_dom
IPR014712 Clathrin_AP_dom2
IPR013809 ENTH
IPR008942 ENTH_VHS
IPR030412 PICALM
PANTHERiPTHR22951:SF16 PTHR22951:SF16, 1 hit
PfamiView protein in Pfam
PF07651 ANTH, 1 hit
SMARTiView protein in SMART
SM00273 ENTH, 1 hit
SUPFAMiSSF48464 SSF48464, 1 hit
PROSITEiView protein in PROSITE
PS50942 ENTH, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPICAL_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q13492
Secondary accession number(s): B4DTM3
, E9PN05, F8VPG7, O60700, Q4LE54, Q6GMQ6, Q86XZ9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 15, 2002
Last sequence update: October 17, 2006
Last modified: January 16, 2019
This is version 177 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
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