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UniProtKB - Q13489 (BIRC3_HUMAN)

Entry version 211 (02 Jun 2021)
Sequence version 2 (01 Nov 1997)
Previous versions | rss
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Protein

Baculoviral IAP repeat-containing protein 3

Gene

BIRC3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, mitogenic kinase signaling and cell proliferation, as well as cell invasion and metastasis. Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and regulates both canonical and non-canonical NF-kappa-B signaling by acting in opposite directions: acts as a positive regulator of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling. The target proteins for its E3 ubiquitin-protein ligase activity include: RIPK1, RIPK2, RIPK3, RIPK4, CASP3, CASP7, CASP8, IKBKE, TRAF1, and BCL10. Acts as an important regulator of innate immune signaling via regulation of Toll-like receptors (TLRs), Nodlike receptors (NLRs) and RIG-I like receptors (RLRs), collectively referred to as pattern recognition receptors (PRRs). Protects cells from spontaneous formation of the ripoptosome, a large multi-protein complex that has the capability to kill cancer cells in a caspase-dependent and caspase-independent manner. Suppresses ripoptosome formation by ubiquitinating RIPK1 and CASP8.

2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

USP19 regulates the stability of BIRC3/c-IAP2 by preventing its ubiquitination.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi292ZincPROSITE-ProRule annotation1
Metal bindingi295ZincPROSITE-ProRule annotation1
Metal bindingi312ZincPROSITE-ProRule annotation1
Metal bindingi319ZincPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri557 – 592RING-typePROSITE-ProRule annotationAdd BLAST36

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionTransferase
Biological processApoptosis, Ubl conjugation pathway
LigandMetal-binding, Zinc

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...BRENDAi		2.3.2.27, 2681

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q13489

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-168638, NOD1/2 Signaling Pathway
R-HSA-168927, TICAM1, RIP1-mediated IKK complex recruitment
R-HSA-5213460, RIPK1-mediated regulated necrosis
R-HSA-5357905, Regulation of TNFR1 signaling
R-HSA-5357956, TNFR1-induced NFkappaB signaling pathway
R-HSA-5668541, TNFR2 non-canonical NF-kB pathway
R-HSA-5675482, Regulation of necroptotic cell death
R-HSA-5676594, TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway
R-HSA-5689880, Ub-specific processing proteases
R-HSA-937041, IKK complex recruitment mediated by RIP1

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q13489

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q13489

Protein family/group databases

MEROPS protease database

More...MEROPSi		I32.003

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Baculoviral IAP repeat-containing protein 3 (EC:2.3.2.272 Publications)
Alternative name(s):
Apoptosis inhibitor 2
Short name:
API2
Cellular inhibitor of apoptosis 2
Short name:
C-IAP21 Publication
IAP homolog C
Inhibitor of apoptosis protein 1
Short name:
hIAP-1
Short name:
hIAP1
RING finger protein 49
RING-type E3 ubiquitin transferase BIRC3Curated
TNFR2-TRAF-signaling complex protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:BIRC3
Synonyms:API2, MIHC, RNF49
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:591, BIRC3

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		601721, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q13489

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000023445.13

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

A chromosomal aberration involving BIRC3 is recurrent in low-grade mucosa-associated lymphoid tissue (MALT lymphoma). Translocation t(11;18)(q21;q21) with MALT1. This translocation is found in approximately 50% of cytogenetically abnormal low-grade MALT lymphoma.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei442 – 443Breakpoint for translocation to form BIRC3-MALT12

Organism-specific databases

DisGeNET

More...DisGeNETi		330

MalaCards human disease database

More...MalaCardsi		BIRC3

Open Targets

More...OpenTargetsi		ENSG00000023445

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		52417, MALT lymphoma

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA25360

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q13489, Tchem

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL5335

IUPHAR/BPS Guide to PHARMACOLOGY

More...GuidetoPHARMACOLOGYi		2792

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		BIRC3

Domain mapping of disease mutations (DMDM)

More...DMDMi		2497236

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001223491 – 604Baculoviral IAP repeat-containing protein 3Add BLAST604

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Auto-ubiquitinated and degraded by the proteasome in apoptotic cells.

Keywords - PTMi

Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q13489

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q13489

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q13489

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q13489

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q13489

PeptideAtlas

More...PeptideAtlasi		Q13489

PRoteomics IDEntifications database

More...PRIDEi		Q13489

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		59483

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q13489

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q13489

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in fetal lung, and kidney. In the adult, expression is mainly seen in lymphoid tissues, including spleen, thymus and peripheral blood lymphocytes.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000023445, Expressed in tonsil and 194 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q13489, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q13489, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000023445, Tissue enhanced (intestine, lymphoid tissue)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with DIABLO/SMAC and with PRSS25; these interactions inhibit apoptotic suppressor activity. The BIR motifs region interacts with TNF receptor associated factors 1 and 2 (TRAF1 and TRAF2) to form a heteromeric complex, which is then recruited to the tumor necrosis factor receptor 2 (TNFR2). Interaction with TRAF2 is required for ubiquitination of IKBKE, degradation of NFKBIA and activation of NF-kappa-B.

Interacts with RIP1, RIP2, RIP3, RIP4 and USP19.

2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		106827, 1316 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		Q13489

Database of interacting proteins

More...DIPi		DIP-33720N

Protein interaction database and analysis system

More...IntActi		Q13489, 41 interactors

Molecular INTeraction database

More...MINTi		Q13489

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000263464

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		Q13489

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q13489, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1604
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q13489

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		Q13489

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati29 – 96BIR 1Add BLAST68
Repeati169 – 235BIR 2Add BLAST67
Repeati255 – 322BIR 3Add BLAST68
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini439 – 529CARDPROSITE-ProRule annotationAdd BLAST91

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the IAP family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri557 – 592RING-typePROSITE-ProRule annotationAdd BLAST36

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1101, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000154175

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_016347_1_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q13489

Identification of Orthologs from Complete Genome Data

More...OMAi		SPIIHFG

Database of Orthologous Groups

More...OrthoDBi		1340284at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q13489

TreeFam database of animal gene trees

More...TreeFami		TF105356

Family and domain databases

Conserved Domains Database

More...CDDi		cd00022, BIR, 3 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001370, BIR_rpt
IPR001315, CARD
IPR011029, DEATH-like_dom_sf
IPR001841, Znf_RING

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00653, BIR, 3 hits
PF00619, CARD, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00238, BIR, 3 hits
SM00114, CARD, 1 hit
SM00184, RING, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF47986, SSF47986, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS01282, BIR_REPEAT_1, 3 hits
PS50143, BIR_REPEAT_2, 3 hits
PS50209, CARD, 1 hit
PS50089, ZF_RING_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q13489-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNIVENSIFL SNLMKSANTF ELKYDLSCEL YRMSTYSTFP AGVPVSERSL 
        60         70         80         90        100
ARAGFYYTGV NDKVKCFCCG LMLDNWKRGD SPTEKHKKLY PSCRFVQSLN 
       110        120        130        140        150
SVNNLEATSQ PTFPSSVTNS THSLLPGTEN SGYFRGSYSN SPSNPVNSRA 
       160        170        180        190        200
NQDFSALMRS SYHCAMNNEN ARLLTFQTWP LTFLSPTDLA KAGFYYIGPG 
       210        220        230        240        250
DRVACFACGG KLSNWEPKDN AMSEHLRHFP KCPFIENQLQ DTSRYTVSNL 
       260        270        280        290        300
SMQTHAARFK TFFNWPSSVL VNPEQLASAG FYYVGNSDDV KCFCCDGGLR 
       310        320        330        340        350
CWESGDDPWV QHAKWFPRCE YLIRIKGQEF IRQVQASYPH LLEQLLSTSD 
       360        370        380        390        400
SPGDENAESS IIHFEPGEDH SEDAIMMNTP VINAAVEMGF SRSLVKQTVQ 
       410        420        430        440        450
RKILATGENY RLVNDLVLDL LNAEDEIREE ERERATEEKE SNDLLLIRKN 
       460        470        480        490        500
RMALFQHLTC VIPILDSLLT AGIINEQEHD VIKQKTQTSL QARELIDTIL 
       510        520        530        540        550
VKGNIAATVF RNSLQEAEAV LYEHLFVQQD IKYIPTEDVS DLPVEEQLRR 
       560        570        580        590        600
LQEERTCKVC MDKEVSIVFI PCGHLVVCKD CAPSLRKCPI CRSTIKGTVR 

TFLS
Length:604
Mass (Da):68,372
Last modified:November 1, 1997 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8581A00BA9AAB4A7
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A669KBC7A0A669KBC7_HUMAN
Baculoviral IAP repeat-containing p...
BIRC3
645Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YCJ5H0YCJ5_HUMAN
Baculoviral IAP repeat-containing p...
BIRC3
216Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti18N → Y in AAC83232 (PubMed:10233894).Curated1
Sequence conflicti119N → H in AAC50371 (PubMed:8552191).Curated1
Sequence conflicti153D → E in AAC50371 (PubMed:8552191).Curated1
Sequence conflicti163H → P in AAC50371 (PubMed:8552191).Curated1
Sequence conflicti165A → P in AAC50371 (PubMed:8552191).Curated1
Sequence conflicti191K → R in AAC50371 (PubMed:8552191).Curated1
Sequence conflicti364F → L in AAC50371 (PubMed:8552191).Curated1
Sequence conflicti552Q → P in AAC50371 (PubMed:8552191).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_021069260K → R1 PublicationCorresponds to variant dbSNP:rs2276113Ensembl.1
Natural variantiVAR_049536386V → M. Corresponds to variant dbSNP:rs12222256Ensembl.1
Natural variantiVAR_021070401R → K1 PublicationCorresponds to variant dbSNP:rs17881197EnsemblClinVar.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
L49432 mRNA Translation: AAC41943.1
U45878 mRNA Translation: AAC50371.1
U37546 mRNA Translation: AAC50507.1
AF070674 mRNA Translation: AAC83232.1
AY764389 Genomic DNA Translation: AAU88144.1
BC037420 mRNA Translation: AAH37420.1
AF178945 Genomic DNA Translation: AAG09369.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS8315.1

Protein sequence database of the Protein Information Resource

More...PIRi		S68449

NCBI Reference Sequences

More...RefSeqi		NP_001156.1, NM_001165.4
NP_892007.1, NM_182962.2
XP_016873132.1, XM_017017643.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000263464; ENSP00000263464; ENSG00000023445
ENST00000526421; ENSP00000501119; ENSG00000023445
ENST00000532808; ENSP00000432907; ENSG00000023445
ENST00000615299; ENSP00000481903; ENSG00000023445

Database of genes from NCBI RefSeq genomes

More...GeneIDi		330

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:330

UCSC genome browser

More...UCSCi		uc001pgx.5, human

Keywords - Coding sequence diversityi

Chromosomal rearrangement

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology
NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L49432 mRNA Translation: AAC41943.1
U45878 mRNA Translation: AAC50371.1
U37546 mRNA Translation: AAC50507.1
AF070674 mRNA Translation: AAC83232.1
AY764389 Genomic DNA Translation: AAU88144.1
BC037420 mRNA Translation: AAH37420.1
AF178945 Genomic DNA Translation: AAG09369.1
CCDSiCCDS8315.1
PIRiS68449
RefSeqiNP_001156.1, NM_001165.4
NP_892007.1, NM_182962.2
XP_016873132.1, XM_017017643.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2UVLX-ray1.91A/B244-337[»]
3EB5X-ray2.00A536-604[»]
3EB6X-ray3.40A536-604[»]
3M0AX-ray2.61D26-99[»]
3M0DX-ray2.80D26-99[»]
SMRiQ13489
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi106827, 1316 interactors
CORUMiQ13489
DIPiDIP-33720N
IntActiQ13489, 41 interactors
MINTiQ13489
STRINGi9606.ENSP00000263464

Chemistry databases

BindingDBiQ13489
ChEMBLiCHEMBL5335
GuidetoPHARMACOLOGYi2792

Protein family/group databases

MEROPSiI32.003

PTM databases

iPTMnetiQ13489
PhosphoSitePlusiQ13489

Genetic variation databases

BioMutaiBIRC3
DMDMi2497236

Proteomic databases

EPDiQ13489
jPOSTiQ13489
MassIVEiQ13489
MaxQBiQ13489
PaxDbiQ13489
PeptideAtlasiQ13489
PRIDEiQ13489
ProteomicsDBi59483

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		1035, 678 antibodies

The DNASU plasmid repository

More...DNASUi		330

Genome annotation databases

EnsembliENST00000263464; ENSP00000263464; ENSG00000023445
ENST00000526421; ENSP00000501119; ENSG00000023445
ENST00000532808; ENSP00000432907; ENSG00000023445
ENST00000615299; ENSP00000481903; ENSG00000023445
GeneIDi330
KEGGihsa:330
UCSCiuc001pgx.5, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		330
DisGeNETi330

GeneCards: human genes, protein and diseases

More...GeneCardsi		BIRC3
HGNCiHGNC:591, BIRC3
HPAiENSG00000023445, Tissue enhanced (intestine, lymphoid tissue)
MalaCardsiBIRC3
MIMi601721, gene
neXtProtiNX_Q13489
OpenTargetsiENSG00000023445
Orphaneti52417, MALT lymphoma
PharmGKBiPA25360
VEuPathDBiHostDB:ENSG00000023445.13

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1101, Eukaryota
GeneTreeiENSGT00940000154175
HOGENOMiCLU_016347_1_1_1
InParanoidiQ13489
OMAiSPIIHFG
OrthoDBi1340284at2759
PhylomeDBiQ13489
TreeFamiTF105356

Enzyme and pathway databases

BRENDAi2.3.2.27, 2681
PathwayCommonsiQ13489
ReactomeiR-HSA-168638, NOD1/2 Signaling Pathway
R-HSA-168927, TICAM1, RIP1-mediated IKK complex recruitment
R-HSA-5213460, RIPK1-mediated regulated necrosis
R-HSA-5357905, Regulation of TNFR1 signaling
R-HSA-5357956, TNFR1-induced NFkappaB signaling pathway
R-HSA-5668541, TNFR2 non-canonical NF-kB pathway
R-HSA-5675482, Regulation of necroptotic cell death
R-HSA-5676594, TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway
R-HSA-5689880, Ub-specific processing proteases
R-HSA-937041, IKK complex recruitment mediated by RIP1
SignaLinkiQ13489
SIGNORiQ13489

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		330, 10 hits in 989 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		BIRC3, human
EvolutionaryTraceiQ13489

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		Baculoviral_IAP_repeat-containing_protein_3

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		330
PharosiQ13489, Tchem

Protein Ontology

More...PROi		PR:Q13489
RNActiQ13489, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000023445, Expressed in tonsil and 194 other tissues
ExpressionAtlasiQ13489, baseline and differential
GenevisibleiQ13489, HS

Family and domain databases

CDDicd00022, BIR, 3 hits
InterProiView protein in InterPro
IPR001370, BIR_rpt
IPR001315, CARD
IPR011029, DEATH-like_dom_sf
IPR001841, Znf_RING
PfamiView protein in Pfam
PF00653, BIR, 3 hits
PF00619, CARD, 1 hit
SMARTiView protein in SMART
SM00238, BIR, 3 hits
SM00114, CARD, 1 hit
SM00184, RING, 1 hit
SUPFAMiSSF47986, SSF47986, 1 hit
PROSITEiView protein in PROSITE
PS01282, BIR_REPEAT_1, 3 hits
PS50143, BIR_REPEAT_2, 3 hits
PS50209, CARD, 1 hit
PS50089, ZF_RING_2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiBIRC3_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q13489
Secondary accession number(s): Q16628, Q9HC27, Q9UP46
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: June 2, 2021
This is version 211 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families
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