BIRC3

Functionⁱ

Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, mitogenic kinase signaling and cell proliferation, as well as cell invasion and metastasis. Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and regulates both canonical and non-canonical NF-kappa-B signaling by acting in opposite directions: acts as a positive regulator of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling. The target proteins for its E3 ubiquitin-protein ligase activity include: RIPK1, RIPK2, RIPK3, RIPK4, CASP3, CASP7, CASP8, IKBKE, TRAF1, and BCL10. Acts as an important regulator of innate immune signaling via regulation of Toll-like receptors (TLRs), Nodlike receptors (NLRs) and RIG-I like receptors (RLRs), collectively referred to as pattern recognition receptors (PRRs). Protects cells from spontaneous formation of the ripoptosome, a large multi-protein complex that has the capability to kill cancer cells in a caspase-dependent and caspase-independent manner. Suppresses ripoptosome formation by ubiquitinating RIPK1 and CASP8.2 Publications

Catalytic activityⁱ

S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N₆-ubiquitinyl-[acceptor protein]-L-lysine.2 Publications

Activity regulationⁱ

USP19 regulates the stability of BIRC3/c-IAP2 by preventing its ubiquitination.1 Publication

Sites

Feature key	Position(s)	DescriptionActions	Length
Metal bindingⁱ	292	ZincPROSITE-ProRule annotation	1
Metal bindingⁱ	295	ZincPROSITE-ProRule annotation	1
Metal bindingⁱ	312	ZincPROSITE-ProRule annotation	1
Metal bindingⁱ	319	ZincPROSITE-ProRule annotation	1

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Zinc fingerⁱ	557 – 592	RING-typePROSITE-ProRule annotationAdd BLAST		36

GO - Molecular functionⁱ

cysteine-type endopeptidase inhibitor activity involved in apoptotic process
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
metal ion binding Source: UniProtKB-KW
transferase activity
Source: Reactome
Inferred from experimentⁱ
- 19008929
ubiquitin protein ligase activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
ubiquitin-protein transferase activity
Source: UniProtKB
Inferred from direct assayⁱ
- 16395405
- 21931591

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cell surface receptor signaling pathway
Source: ProtInc
Traceable author statementⁱ
- 8548810
I-kappaB kinase/NF-kappaB signaling Source: Reactome
inhibition of cysteine-type endopeptidase activity involved in apoptotic process
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
negative regulation of apoptotic process
Source: ProtInc
Traceable author statementⁱ
- 8552191
negative regulation of necroptotic process
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
NIK/NF-kappaB signaling
Source: UniProtKB
Traceable author statementⁱ
- 20651737
positive regulation of I-kappaB kinase/NF-kappaB signaling
Source: UniProtKB
Traceable author statementⁱ
- 20651737
positive regulation of protein ubiquitination
Source: UniProtKB
Inferred from direct assayⁱ
- 21931591
protein deubiquitination Source: Reactome
protein heterooligomerization Source: Ensembl
regulation of apoptotic process
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 21737330
regulation of cysteine-type endopeptidase activity
Source: UniProtKB
Traceable author statementⁱ
- 20651737
regulation of inflammatory response
Source: UniProtKB
Traceable author statementⁱ
- 21447281
regulation of innate immune response
Source: UniProtKB
Traceable author statementⁱ
- 21447281
regulation of necroptotic process
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 21737330
regulation of nucleotide-binding oligomerization domain containing signaling pathway
Source: UniProtKB
Traceable author statementⁱ
- 20888210
regulation of RIG-I signaling pathway
Source: UniProtKB
Traceable author statementⁱ
- 20888210
regulation of toll-like receptor signaling pathway
Source: UniProtKB
Traceable author statementⁱ
- 20888210
regulation of tumor necrosis factor-mediated signaling pathway Source: Reactome
spermatogenesis Source: Ensembl
tumor necrosis factor-mediated signaling pathway Source: Reactome

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Transferase
Biological process	Apoptosis, Ubl conjugation pathway
Ligand	Metal-binding, Zinc

Enzyme and pathway databases

Reactomeⁱ	R-HSA-168638 NOD1/2 Signaling Pathway R-HSA-168927 TICAM1, RIP1-mediated IKK complex recruitment R-HSA-5213460 RIPK1-mediated regulated necrosis R-HSA-5357905 Regulation of TNFR1 signaling R-HSA-5357956 TNFR1-induced NFkappaB signaling pathway R-HSA-5668541 TNFR2 non-canonical NF-kB pathway R-HSA-5675482 Regulation of necroptotic cell death R-HSA-5676594 TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway R-HSA-5689880 Ub-specific processing proteases R-HSA-937041 IKK complex recruitment mediated by RIP1
SignaLinkⁱ	Q13489
SIGNORⁱ	Q13489

Protein family/group databases

MEROPS protease database More...MEROPSⁱ	I32.007

MEROPSⁱ

I32.007

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Baculoviral IAP repeat-containing protein 3 (EC:2.3.2.272 Publications) Alternative name(s): Apoptosis inhibitor 2 Short name: API2 Cellular inhibitor of apoptosis 2 Short name: C-IAP21 Publication IAP homolog C Inhibitor of apoptosis protein 1 Short name: hIAP-1 Short name: hIAP1 RING finger protein 49 RING-type E3 ubiquitin transferase BIRC3Curated TNFR2-TRAF-signaling complex protein 1
Gene namesⁱ	Name:BIRC3 Synonyms:API2, MIHC, RNF49
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 11

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000023445.13
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:591 BIRC3
MIMⁱ	601721 gene
neXtProtⁱ	NX_Q13489

Keywords - Cellular componentⁱ

Cytoplasm, Nucleus

Pathology & Biotechⁱ

Involvement in diseaseⁱ

A chromosomal aberration involving BIRC3 is recurrent in low-grade mucosa-associated lymphoid tissue (MALT lymphoma). Translocation t(11;18)(q21;q21) with MALT1. This translocation is found in approximately 50% of cytogenetically abnormal low-grade MALT lymphoma.

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Siteⁱ	442 – 443	Breakpoint for translocation to form BIRC3-MALT1		2

Organism-specific databases

DisGeNET More...DisGeNETⁱ	330
MalaCards human disease database More...MalaCardsⁱ	BIRC3
Open Targets More...OpenTargetsⁱ	ENSG00000023445
Orphanetⁱ	52417 MALT lymphoma
PharmGKBⁱ	PA25360

Chemistry databases

ChEMBLⁱ	CHEMBL5335
IUPHAR/BPS Guide to PHARMACOLOGY More...GuidetoPHARMACOLOGYⁱ	2792

Polymorphism and mutation databases

BioMutaⁱ	BIRC3
DMDMⁱ	2497236

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000122349	1 – 604	Baculoviral IAP repeat-containing protein 3Add BLAST		604

Post-translational modificationⁱ

Auto-ubiquitinated and degraded by the proteasome in apoptotic cells.

Keywords - PTMⁱ

Ubl conjugation

Proteomic databases

EPDⁱ	Q13489
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q13489
PaxDbⁱ	Q13489
PeptideAtlas More...PeptideAtlasⁱ	Q13489
PRIDEⁱ	Q13489
ProteomicsDBⁱ	59483

PTM databases

iPTMnetⁱ	Q13489
PhosphoSitePlusⁱ	Q13489

Miscellaneous databases

PMAP-CutDBⁱ	Q13489

PMAP-CutDBⁱ

Q13489

Expressionⁱ

Tissue specificityⁱ

Highly expressed in fetal lung, and kidney. In the adult, expression is mainly seen in lymphoid tissues, including spleen, thymus and peripheral blood lymphocytes.

Gene expression databases

Bgeeⁱ	ENSG00000023445 Expressed in 172 organ(s), highest expression level in epithelium of nasopharynx
CleanExⁱ	HS_BIRC3
ExpressionAtlasⁱ	Q13489 baseline and differential
Genevisibleⁱ	Q13489 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA002317

HPAⁱ

HPA002317

Interactionⁱ

Subunit structureⁱ

Interacts with DIABLO/SMAC and with PRSS25; these interactions inhibit apoptotic suppressor activity. The BIR motifs region interacts with TNF receptor associated factors 1 and 2 (TRAF1 and TRAF2) to form a heteromeric complex, which is then recruited to the tumor necrosis factor receptor 2 (TNFR2). Interaction with TRAF2 is required for ubiquitination of IKBKE, degradation of NFKBIA and activation of NF-kappa-B. Interacts with RIP1, RIP2, RIP3, RIP4 and USP19.2 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
CASP9	P55211	2	EBI-517709,EBI-516799
RIPK1	Q13546	3	EBI-517709,EBI-358507
RIPK2	O43353	3	EBI-517709,EBI-358522
RIPK3	Q9Y572	3	EBI-517709,EBI-298250
RIPK4	P57078	3	EBI-517709,EBI-4422308
TRAF1	Q13077	2	EBI-517709,EBI-359224
TRAF2	Q12933	7	EBI-517709,EBI-355744
UBE2D2	P62837	2	EBI-517709,EBI-347677
UBE2N	P61088	2	EBI-517709,EBI-1052908

Protein-protein interaction databases

BioGridⁱ	106827, 81 interactors
CORUMⁱ	Q13489
Database of interacting proteins More...DIPⁱ	DIP-33720N
IntActⁱ	Q13489, 40 interactors
Molecular INTeraction database More...MINTⁱ	Q13489
STRINGⁱ	9606.ENSP00000263464

Chemistry databases

BindingDBⁱ

Q13489

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	28 – 34	Combined sources	7
Helixⁱ	35 – 38	Combined sources	4
Helixⁱ	47 – 52	Combined sources	6
Beta strandⁱ	55 – 57	Combined sources	3
Beta strandⁱ	64 – 66	Combined sources	3
Turnⁱ	67 – 69	Combined sources	3
Helixⁱ	82 – 89	Combined sources	8
Turnⁱ	94 – 97	Combined sources	4
Helixⁱ	250 – 252	Combined sources	3
Helixⁱ	255 – 260	Combined sources	6
Helixⁱ	261 – 264	Combined sources	4
Helixⁱ	273 – 278	Combined sources	6
Beta strandⁱ	281 – 285	Combined sources	5
Turnⁱ	286 – 288	Combined sources	3
Beta strandⁱ	289 – 292	Combined sources	4
Turnⁱ	293 – 295	Combined sources	3
Beta strandⁱ	298 – 301	Combined sources	4
Helixⁱ	308 – 315	Combined sources	8
Helixⁱ	320 – 334	Combined sources	15
Helixⁱ	544 – 555	Combined sources	12
Turnⁱ	558 – 560	Combined sources	3
Beta strandⁱ	561 – 564	Combined sources	4
Beta strandⁱ	567 – 570	Combined sources	4
Beta strandⁱ	575 – 577	Combined sources	3
Turnⁱ	579 – 581	Combined sources	3
Helixⁱ	582 – 584	Combined sources	3
Beta strandⁱ	589 – 591	Combined sources	3
Beta strandⁱ	597 – 600	Combined sources	4

Show more details

3D structure databases

ProteinModelPortalⁱ	Q13489
SMRⁱ	Q13489
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	Q13489

EvolutionaryTraceⁱ

Q13489

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Repeatⁱ	29 – 96	BIR 1Add BLAST	68
Repeatⁱ	169 – 235	BIR 2Add BLAST	67
Repeatⁱ	255 – 322	BIR 3Add BLAST	68
Domainⁱ	439 – 529	CARDPROSITE-ProRule annotationAdd BLAST	91

Sequence similaritiesⁱ

Belongs to the IAP family.Curated

Zinc finger

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Zinc fingerⁱ	557 – 592	RING-typePROSITE-ProRule annotationAdd BLAST		36

Keywords - Domainⁱ

Repeat, Zinc-finger

Phylogenomic databases

eggNOGⁱ	KOG1101 Eukaryota ENOG410YPNM LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00500000044782
HOGENOMⁱ	HOG000232059
HOVERGENⁱ	HBG004848
InParanoidⁱ	Q13489
KEGG Orthology (KO) More...KOⁱ	K16060
OMAⁱ	CAMNTEK
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0CXH
PhylomeDBⁱ	Q13489
TreeFamⁱ	TF105356

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00022 BIR, 3 hits
InterProⁱ	View protein in InterPro IPR001370 BIR_rpt IPR001315 CARD IPR011029 DEATH-like_dom_sf IPR001841 Znf_RING
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00653 BIR, 3 hits PF00619 CARD, 1 hit
SMARTⁱ	View protein in SMART SM00238 BIR, 3 hits SM00114 CARD, 1 hit SM00184 RING, 1 hit
SUPFAMⁱ	SSF47986 SSF47986, 1 hit
PROSITEⁱ	View protein in PROSITE PS01282 BIR_REPEAT_1, 3 hits PS50143 BIR_REPEAT_2, 3 hits PS50209 CARD, 1 hit PS50089 ZF_RING_2, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show all Align All

Q13489-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MNIVENSIFL SNLMKSANTF ELKYDLSCEL YRMSTYSTFP AGVPVSERSL 
        60         70         80         90        100
ARAGFYYTGV NDKVKCFCCG LMLDNWKRGD SPTEKHKKLY PSCRFVQSLN 
       110        120        130        140        150
SVNNLEATSQ PTFPSSVTNS THSLLPGTEN SGYFRGSYSN SPSNPVNSRA 
       160        170        180        190        200
NQDFSALMRS SYHCAMNNEN ARLLTFQTWP LTFLSPTDLA KAGFYYIGPG 
       210        220        230        240        250
DRVACFACGG KLSNWEPKDN AMSEHLRHFP KCPFIENQLQ DTSRYTVSNL 
       260        270        280        290        300
SMQTHAARFK TFFNWPSSVL VNPEQLASAG FYYVGNSDDV KCFCCDGGLR 
       310        320        330        340        350
CWESGDDPWV QHAKWFPRCE YLIRIKGQEF IRQVQASYPH LLEQLLSTSD 
       360        370        380        390        400
SPGDENAESS IIHFEPGEDH SEDAIMMNTP VINAAVEMGF SRSLVKQTVQ 
       410        420        430        440        450
RKILATGENY RLVNDLVLDL LNAEDEIREE ERERATEEKE SNDLLLIRKN 
       460        470        480        490        500
RMALFQHLTC VIPILDSLLT AGIINEQEHD VIKQKTQTSL QARELIDTIL 
       510        520        530        540        550
VKGNIAATVF RNSLQEAEAV LYEHLFVQQD IKYIPTEDVS DLPVEEQLRR 
       560        570        580        590        600
LQEERTCKVC MDKEVSIVFI PCGHLVVCKD CAPSLRKCPI CRSTIKGTVR 

TFLS

Length:604

Mass (Da):68,372

Last modified:November 1, 1997 - v2

Checksum:ⁱ8581A00BA9AAB4A7

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	H0YCJ5	H0YCJ5_HUMAN		Baculoviral IAP repeat-containing p... Baculoviral IAP repeat-containing protein 3	BIRC3	183	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	18	N → Y in AAC83232 (PubMed:10233894).Curated	1
Sequence conflictⁱ	119	N → H in AAC50371 (PubMed:8552191).Curated	1
Sequence conflictⁱ	153	D → E in AAC50371 (PubMed:8552191).Curated	1
Sequence conflictⁱ	163	H → P in AAC50371 (PubMed:8552191).Curated	1
Sequence conflictⁱ	165	A → P in AAC50371 (PubMed:8552191).Curated	1
Sequence conflictⁱ	191	K → R in AAC50371 (PubMed:8552191).Curated	1
Sequence conflictⁱ	364	F → L in AAC50371 (PubMed:8552191).Curated	1
Sequence conflictⁱ	552	Q → P in AAC50371 (PubMed:8552191).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_021069	260	K → R1 PublicationCorresponds to variant dbSNP:rs2276113Ensembl.	1
Natural variantⁱVAR_049536	386	V → M. Corresponds to variant dbSNP:rs12222256Ensembl.	1
Natural variantⁱVAR_021070	401	R → K1 PublicationCorresponds to variant dbSNP:rs17881197Ensembl.	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	L49432 mRNA Translation: AAC41943.1 U45878 mRNA Translation: AAC50371.1 U37546 mRNA Translation: AAC50507.1 AF070674 mRNA Translation: AAC83232.1 AY764389 Genomic DNA Translation: AAU88144.1 BC037420 mRNA Translation: AAH37420.1 AF178945 Genomic DNA Translation: AAG09369.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS8315.1
PIRⁱ	S68449
NCBI Reference Sequences More...RefSeqⁱ	NP_001156.1, NM_001165.4 NP_892007.1, NM_182962.2 XP_016873132.1, XM_017017643.1
UniGeneⁱ	Hs.127799

Genome annotation databases

Ensemblⁱ	ENST00000263464; ENSP00000263464; ENSG00000023445 ENST00000532808; ENSP00000432907; ENSG00000023445 ENST00000615299; ENSP00000481903; ENSG00000023445
GeneIDⁱ	330
KEGGⁱ	hsa:330
UCSC genome browser More...UCSCⁱ	uc001pgx.5 human

Keywords - Coding sequence diversityⁱ

Chromosomal rearrangement, Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q13489	Baculoviral IAP repeat containing 3		PANTR		610	UniRef90_Q13489
Baculoviral IAP repeat containing 3		MACFA		604
Baculoviral IAP repeat-containing protein 3		MACMU		604
Uncharacterized protein		MACNE		604
BIRC3 isoform 1		PONAB		604
+26

Protein	Similar proteins		Species	Score	Length	Source
Q13489	Baculoviral IAP repeat-containing protein 2	)	HUMAN		618	UniRef50_Q13490
Baculoviral IAP repeat-containing protein 2		MOUSE		612
Baculoviral IAP repeat-containing protein 3		CANLF		604
Inhibitor of apoptosis protein		CHICK		611
Uncharacterized protein		PANPA		618
+491

Cross-referencesⁱ

Web resourcesⁱ

Atlas of Genetics and Cytogenetics in Oncology and Haematology

NIEHS-SNPs

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	L49432 mRNA Translation: AAC41943.1 U45878 mRNA Translation: AAC50371.1 U37546 mRNA Translation: AAC50507.1 AF070674 mRNA Translation: AAC83232.1 AY764389 Genomic DNA Translation: AAU88144.1 BC037420 mRNA Translation: AAH37420.1 AF178945 Genomic DNA Translation: AAG09369.1
CCDSⁱ	CCDS8315.1
PIRⁱ	S68449
RefSeqⁱ	NP_001156.1, NM_001165.4 NP_892007.1, NM_182962.2 XP_016873132.1, XM_017017643.1
UniGeneⁱ	Hs.127799

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2UVL	X-ray	1.91	A/B	244-337	[»]
	3EB5	X-ray	2.00	A	536-604	[»]
	3EB6	X-ray	3.40	A	536-604	[»]
	3M0A	X-ray	2.61	D	26-99	[»]
	3M0D	X-ray	2.80	D	26-99	[»]
ProteinModelPortalⁱ	Q13489
SMRⁱ	Q13489
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	106827, 81 interactors
CORUMⁱ	Q13489
DIPⁱ	DIP-33720N
IntActⁱ	Q13489, 40 interactors
MINTⁱ	Q13489
STRINGⁱ	9606.ENSP00000263464

Chemistry databases

BindingDBⁱ	Q13489
ChEMBLⁱ	CHEMBL5335
GuidetoPHARMACOLOGYⁱ	2792

Protein family/group databases

MEROPSⁱ	I32.007

MEROPSⁱ

I32.007

PTM databases

iPTMnetⁱ	Q13489
PhosphoSitePlusⁱ	Q13489

Polymorphism and mutation databases

BioMutaⁱ	BIRC3
DMDMⁱ	2497236

Proteomic databases

EPDⁱ	Q13489
MaxQBⁱ	Q13489
PaxDbⁱ	Q13489
PeptideAtlasⁱ	Q13489
PRIDEⁱ	Q13489
ProteomicsDBⁱ	59483

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000263464; ENSP00000263464; ENSG00000023445 ENST00000532808; ENSP00000432907; ENSG00000023445 ENST00000615299; ENSP00000481903; ENSG00000023445
GeneIDⁱ	330
KEGGⁱ	hsa:330
UCSCⁱ	uc001pgx.5 human

Organism-specific databases

CTDⁱ	330
DisGeNETⁱ	330
EuPathDBⁱ	HostDB:ENSG00000023445.13
GeneCardsⁱ	BIRC3
HGNCⁱ	HGNC:591 BIRC3
HPAⁱ	HPA002317
MalaCardsⁱ	BIRC3
MIMⁱ	601721 gene
neXtProtⁱ	NX_Q13489
OpenTargetsⁱ	ENSG00000023445
Orphanetⁱ	52417 MALT lymphoma
PharmGKBⁱ	PA25360
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG1101 Eukaryota ENOG410YPNM LUCA
GeneTreeⁱ	ENSGT00500000044782
HOGENOMⁱ	HOG000232059
HOVERGENⁱ	HBG004848
InParanoidⁱ	Q13489
KOⁱ	K16060
OMAⁱ	CAMNTEK
OrthoDBⁱ	EOG091G0CXH
PhylomeDBⁱ	Q13489
TreeFamⁱ	TF105356

Enzyme and pathway databases

Reactomeⁱ	R-HSA-168638 NOD1/2 Signaling Pathway R-HSA-168927 TICAM1, RIP1-mediated IKK complex recruitment R-HSA-5213460 RIPK1-mediated regulated necrosis R-HSA-5357905 Regulation of TNFR1 signaling R-HSA-5357956 TNFR1-induced NFkappaB signaling pathway R-HSA-5668541 TNFR2 non-canonical NF-kB pathway R-HSA-5675482 Regulation of necroptotic cell death R-HSA-5676594 TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway R-HSA-5689880 Ub-specific processing proteases R-HSA-937041 IKK complex recruitment mediated by RIP1
SignaLinkⁱ	Q13489
SIGNORⁱ	Q13489

Miscellaneous databases

ChiTaRSⁱ	BIRC3 human
EvolutionaryTraceⁱ	Q13489
GeneWikiⁱ	Baculoviral_IAP_repeat-containing_protein_3
GenomeRNAiⁱ	330
PMAP-CutDBⁱ	Q13489
Protein Ontology More...PROⁱ	PR:Q13489
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000023445 Expressed in 172 organ(s), highest expression level in epithelium of nasopharynx
CleanExⁱ	HS_BIRC3
ExpressionAtlasⁱ	Q13489 baseline and differential
Genevisibleⁱ	Q13489 HS

Family and domain databases

CDDⁱ	cd00022 BIR, 3 hits
InterProⁱ	View protein in InterPro IPR001370 BIR_rpt IPR001315 CARD IPR011029 DEATH-like_dom_sf IPR001841 Znf_RING
Pfamⁱ	View protein in Pfam PF00653 BIR, 3 hits PF00619 CARD, 1 hit
SMARTⁱ	View protein in SMART SM00238 BIR, 3 hits SM00114 CARD, 1 hit SM00184 RING, 1 hit
SUPFAMⁱ	SSF47986 SSF47986, 1 hit
PROSITEⁱ	View protein in PROSITE PS01282 BIR_REPEAT_1, 3 hits PS50143 BIR_REPEAT_2, 3 hits PS50209 CARD, 1 hit PS50089 ZF_RING_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	BIRC3_HUMAN
Accessionⁱ	Q13489Primary (citable) accession number: Q13489 Secondary accession number(s): Q16628, Q9HC27, Q9UP46
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
	Last sequence update:	November 1, 1997
	Last modified:	November 7, 2018
	This is version 194 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM

UniProtKB

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Supporting data

UniProtKB - Q13489 (BIRC3_HUMAN)

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Baculoviral IAP repeat-containing protein 3

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Other locations

Cytosol

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Sites

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Keywords - PTMi

Proteomic databases

PTM databases

Miscellaneous databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ