UniProtKB - Q13489 (BIRC3_HUMAN)
Baculoviral IAP repeat-containing protein 3
BIRC3
Functioni
Catalytic activityi
- S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.2 Publications EC:2.3.2.27
Activity regulationi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 292 | ZincPROSITE-ProRule annotation | 1 | |
Metal bindingi | 295 | ZincPROSITE-ProRule annotation | 1 | |
Metal bindingi | 312 | ZincPROSITE-ProRule annotation | 1 | |
Metal bindingi | 319 | ZincPROSITE-ProRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 557 – 592 | RING-typePROSITE-ProRule annotationAdd BLAST | 36 |
GO - Molecular functioni
- cysteine-type endopeptidase inhibitor activity involved in apoptotic process Source: GO_Central
- metal ion binding Source: UniProtKB-KW
- transferase activity Source: Reactome
- ubiquitin protein ligase activity Source: GO_Central
- ubiquitin-protein transferase activity Source: UniProtKB
GO - Biological processi
- cell surface receptor signaling pathway Source: ProtInc
- I-kappaB kinase/NF-kappaB signaling Source: Reactome
- inhibition of cysteine-type endopeptidase activity involved in apoptotic process Source: GO_Central
- MyD88-independent toll-like receptor signaling pathway Source: Reactome
- negative regulation of apoptotic process Source: ProtInc
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: GO_Central
- negative regulation of necroptotic process Source: GO_Central
- NIK/NF-kappaB signaling Source: UniProtKB
- positive regulation of I-kappaB kinase/NF-kappaB signaling Source: UniProtKB
- positive regulation of protein ubiquitination Source: UniProtKB
- protein deubiquitination Source: Reactome
- regulation of apoptotic process Source: UniProtKB
- regulation of cysteine-type endopeptidase activity Source: UniProtKB
- regulation of inflammatory response Source: UniProtKB
- regulation of innate immune response Source: UniProtKB
- regulation of necroptotic process Source: UniProtKB
- regulation of nucleotide-binding oligomerization domain containing signaling pathway Source: UniProtKB
- regulation of RIG-I signaling pathway Source: UniProtKB
- regulation of toll-like receptor signaling pathway Source: UniProtKB
- regulation of tumor necrosis factor-mediated signaling pathway Source: Reactome
- TRIF-dependent toll-like receptor signaling pathway Source: Reactome
- tumor necrosis factor-mediated signaling pathway Source: Reactome
Keywordsi
Molecular function | Transferase |
Biological process | Apoptosis, Ubl conjugation pathway |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q13489 |
Reactomei | R-HSA-168638, NOD1/2 Signaling Pathway R-HSA-168927, TICAM1, RIP1-mediated IKK complex recruitment R-HSA-5213460, RIPK1-mediated regulated necrosis R-HSA-5357905, Regulation of TNFR1 signaling R-HSA-5357956, TNFR1-induced NFkappaB signaling pathway R-HSA-5668541, TNFR2 non-canonical NF-kB pathway R-HSA-5675482, Regulation of necroptotic cell death R-HSA-5676594, TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway R-HSA-5689880, Ub-specific processing proteases R-HSA-937041, IKK complex recruitment mediated by RIP1 |
SignaLinki | Q13489 |
SIGNORi | Q13489 |
Protein family/group databases
MEROPSi | I32.007 |
Names & Taxonomyi
Protein namesi | Recommended name: Baculoviral IAP repeat-containing protein 3 (EC:2.3.2.272 Publications)Alternative name(s): Apoptosis inhibitor 2 Short name: API2 Cellular inhibitor of apoptosis 2 Short name: C-IAP21 Publication IAP homolog C Inhibitor of apoptosis protein 1 Short name: hIAP-1 Short name: hIAP1 RING finger protein 49 RING-type E3 ubiquitin transferase BIRC3Curated TNFR2-TRAF-signaling complex protein 1 |
Gene namesi | Name:BIRC3 Synonyms:API2, MIHC, RNF49 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:591, BIRC3 |
MIMi | 601721, gene |
neXtProti | NX_Q13489 |
VEuPathDBi | HostDB:ENSG00000023445.13 |
Subcellular locationi
Cytosol
- cytosol Source: HPA
Nucleus
- nucleoplasm Source: HPA
- nucleus Source: UniProtKB
Other locations
- cytoplasm Source: UniProtKB
Keywords - Cellular componenti
Cytoplasm, NucleusPathology & Biotechi
Involvement in diseasei
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 442 – 443 | Breakpoint for translocation to form BIRC3-MALT1 | 2 |
Organism-specific databases
DisGeNETi | 330 |
MalaCardsi | BIRC3 |
OpenTargetsi | ENSG00000023445 |
Orphaneti | 52417, MALT lymphoma |
PharmGKBi | PA25360 |
Miscellaneous databases
Pharosi | Q13489, Tchem |
Chemistry databases
ChEMBLi | CHEMBL5335 |
GuidetoPHARMACOLOGYi | 2792 |
Genetic variation databases
BioMutai | BIRC3 |
DMDMi | 2497236 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000122349 | 1 – 604 | Baculoviral IAP repeat-containing protein 3Add BLAST | 604 |
Post-translational modificationi
Keywords - PTMi
Ubl conjugationProteomic databases
EPDi | Q13489 |
jPOSTi | Q13489 |
MassIVEi | Q13489 |
MaxQBi | Q13489 |
PaxDbi | Q13489 |
PeptideAtlasi | Q13489 |
PRIDEi | Q13489 |
ProteomicsDBi | 59483 |
PTM databases
iPTMneti | Q13489 |
PhosphoSitePlusi | Q13489 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000023445, Expressed in tonsil and 194 other tissues |
ExpressionAtlasi | Q13489, baseline and differential |
Genevisiblei | Q13489, HS |
Organism-specific databases
HPAi | ENSG00000023445, Tissue enhanced (intestine, lymphoid tissue) |
Interactioni
Subunit structurei
Interacts with DIABLO/SMAC and with PRSS25; these interactions inhibit apoptotic suppressor activity. The BIR motifs region interacts with TNF receptor associated factors 1 and 2 (TRAF1 and TRAF2) to form a heteromeric complex, which is then recruited to the tumor necrosis factor receptor 2 (TNFR2). Interaction with TRAF2 is required for ubiquitination of IKBKE, degradation of NFKBIA and activation of NF-kappa-B.
Interacts with RIP1, RIP2, RIP3, RIP4 and USP19.
2 PublicationsBinary interactionsi
Hide detailsQ13489
Protein-protein interaction databases
BioGRIDi | 106827, 1316 interactors |
CORUMi | Q13489 |
DIPi | DIP-33720N |
IntActi | Q13489, 41 interactors |
MINTi | Q13489 |
STRINGi | 9606.ENSP00000263464 |
Chemistry databases
BindingDBi | Q13489 |
Miscellaneous databases
RNActi | Q13489, protein |
Structurei
Secondary structure
3D structure databases
SMRi | Q13489 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q13489 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 29 – 96 | BIR 1Add BLAST | 68 | |
Repeati | 169 – 235 | BIR 2Add BLAST | 67 | |
Repeati | 255 – 322 | BIR 3Add BLAST | 68 | |
Domaini | 439 – 529 | CARDPROSITE-ProRule annotationAdd BLAST | 91 |
Sequence similaritiesi
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 557 – 592 | RING-typePROSITE-ProRule annotationAdd BLAST | 36 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1101, Eukaryota |
GeneTreei | ENSGT00940000154175 |
HOGENOMi | CLU_016347_1_1_1 |
InParanoidi | Q13489 |
OMAi | SPIIHFG |
OrthoDBi | 1340284at2759 |
PhylomeDBi | Q13489 |
TreeFami | TF105356 |
Family and domain databases
CDDi | cd00022, BIR, 3 hits |
InterProi | View protein in InterPro IPR001370, BIR_rpt IPR001315, CARD IPR011029, DEATH-like_dom_sf IPR001841, Znf_RING |
Pfami | View protein in Pfam PF00653, BIR, 3 hits PF00619, CARD, 1 hit |
SMARTi | View protein in SMART SM00238, BIR, 3 hits SM00114, CARD, 1 hit SM00184, RING, 1 hit |
SUPFAMi | SSF47986, SSF47986, 1 hit |
PROSITEi | View protein in PROSITE PS01282, BIR_REPEAT_1, 3 hits PS50143, BIR_REPEAT_2, 3 hits PS50209, CARD, 1 hit PS50089, ZF_RING_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
10 20 30 40 50
MNIVENSIFL SNLMKSANTF ELKYDLSCEL YRMSTYSTFP AGVPVSERSL
60 70 80 90 100
ARAGFYYTGV NDKVKCFCCG LMLDNWKRGD SPTEKHKKLY PSCRFVQSLN
110 120 130 140 150
SVNNLEATSQ PTFPSSVTNS THSLLPGTEN SGYFRGSYSN SPSNPVNSRA
160 170 180 190 200
NQDFSALMRS SYHCAMNNEN ARLLTFQTWP LTFLSPTDLA KAGFYYIGPG
210 220 230 240 250
DRVACFACGG KLSNWEPKDN AMSEHLRHFP KCPFIENQLQ DTSRYTVSNL
260 270 280 290 300
SMQTHAARFK TFFNWPSSVL VNPEQLASAG FYYVGNSDDV KCFCCDGGLR
310 320 330 340 350
CWESGDDPWV QHAKWFPRCE YLIRIKGQEF IRQVQASYPH LLEQLLSTSD
360 370 380 390 400
SPGDENAESS IIHFEPGEDH SEDAIMMNTP VINAAVEMGF SRSLVKQTVQ
410 420 430 440 450
RKILATGENY RLVNDLVLDL LNAEDEIREE ERERATEEKE SNDLLLIRKN
460 470 480 490 500
RMALFQHLTC VIPILDSLLT AGIINEQEHD VIKQKTQTSL QARELIDTIL
510 520 530 540 550
VKGNIAATVF RNSLQEAEAV LYEHLFVQQD IKYIPTEDVS DLPVEEQLRR
560 570 580 590 600
LQEERTCKVC MDKEVSIVFI PCGHLVVCKD CAPSLRKCPI CRSTIKGTVR
TFLS
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A669KBC7 | A0A669KBC7_HUMAN | Baculoviral IAP repeat-containing p... | BIRC3 | 645 | Annotation score: | ||
H0YCJ5 | H0YCJ5_HUMAN | Baculoviral IAP repeat-containing p... | BIRC3 | 216 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 18 | N → Y in AAC83232 (PubMed:10233894).Curated | 1 | |
Sequence conflicti | 119 | N → H in AAC50371 (PubMed:8552191).Curated | 1 | |
Sequence conflicti | 153 | D → E in AAC50371 (PubMed:8552191).Curated | 1 | |
Sequence conflicti | 163 | H → P in AAC50371 (PubMed:8552191).Curated | 1 | |
Sequence conflicti | 165 | A → P in AAC50371 (PubMed:8552191).Curated | 1 | |
Sequence conflicti | 191 | K → R in AAC50371 (PubMed:8552191).Curated | 1 | |
Sequence conflicti | 364 | F → L in AAC50371 (PubMed:8552191).Curated | 1 | |
Sequence conflicti | 552 | Q → P in AAC50371 (PubMed:8552191).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_021069 | 260 | K → R1 PublicationCorresponds to variant dbSNP:rs2276113Ensembl. | 1 | |
Natural variantiVAR_049536 | 386 | V → M. Corresponds to variant dbSNP:rs12222256Ensembl. | 1 | |
Natural variantiVAR_021070 | 401 | R → K1 PublicationCorresponds to variant dbSNP:rs17881197EnsemblClinVar. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L49432 mRNA Translation: AAC41943.1 U45878 mRNA Translation: AAC50371.1 U37546 mRNA Translation: AAC50507.1 AF070674 mRNA Translation: AAC83232.1 AY764389 Genomic DNA Translation: AAU88144.1 BC037420 mRNA Translation: AAH37420.1 AF178945 Genomic DNA Translation: AAG09369.1 |
CCDSi | CCDS8315.1 |
PIRi | S68449 |
RefSeqi | NP_001156.1, NM_001165.4 NP_892007.1, NM_182962.2 XP_016873132.1, XM_017017643.1 |
Genome annotation databases
Ensembli | ENST00000263464; ENSP00000263464; ENSG00000023445 ENST00000526421; ENSP00000501119; ENSG00000023445 ENST00000532808; ENSP00000432907; ENSG00000023445 ENST00000615299; ENSP00000481903; ENSG00000023445 |
GeneIDi | 330 |
KEGGi | hsa:330 |
UCSCi | uc001pgx.5, human |
Keywords - Coding sequence diversityi
Chromosomal rearrangementSimilar proteinsi
Cross-referencesi
Web resourcesi
Atlas of Genetics and Cytogenetics in Oncology and Haematology |
NIEHS-SNPs |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L49432 mRNA Translation: AAC41943.1 U45878 mRNA Translation: AAC50371.1 U37546 mRNA Translation: AAC50507.1 AF070674 mRNA Translation: AAC83232.1 AY764389 Genomic DNA Translation: AAU88144.1 BC037420 mRNA Translation: AAH37420.1 AF178945 Genomic DNA Translation: AAG09369.1 |
CCDSi | CCDS8315.1 |
PIRi | S68449 |
RefSeqi | NP_001156.1, NM_001165.4 NP_892007.1, NM_182962.2 XP_016873132.1, XM_017017643.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2UVL | X-ray | 1.91 | A/B | 244-337 | [»] | |
3EB5 | X-ray | 2.00 | A | 536-604 | [»] | |
3EB6 | X-ray | 3.40 | A | 536-604 | [»] | |
3M0A | X-ray | 2.61 | D | 26-99 | [»] | |
3M0D | X-ray | 2.80 | D | 26-99 | [»] | |
SMRi | Q13489 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 106827, 1316 interactors |
CORUMi | Q13489 |
DIPi | DIP-33720N |
IntActi | Q13489, 41 interactors |
MINTi | Q13489 |
STRINGi | 9606.ENSP00000263464 |
Chemistry databases
BindingDBi | Q13489 |
ChEMBLi | CHEMBL5335 |
GuidetoPHARMACOLOGYi | 2792 |
Protein family/group databases
MEROPSi | I32.007 |
PTM databases
iPTMneti | Q13489 |
PhosphoSitePlusi | Q13489 |
Genetic variation databases
BioMutai | BIRC3 |
DMDMi | 2497236 |
Proteomic databases
EPDi | Q13489 |
jPOSTi | Q13489 |
MassIVEi | Q13489 |
MaxQBi | Q13489 |
PaxDbi | Q13489 |
PeptideAtlasi | Q13489 |
PRIDEi | Q13489 |
ProteomicsDBi | 59483 |
Protocols and materials databases
Antibodypediai | 1035, 672 antibodies |
Genome annotation databases
Ensembli | ENST00000263464; ENSP00000263464; ENSG00000023445 ENST00000526421; ENSP00000501119; ENSG00000023445 ENST00000532808; ENSP00000432907; ENSG00000023445 ENST00000615299; ENSP00000481903; ENSG00000023445 |
GeneIDi | 330 |
KEGGi | hsa:330 |
UCSCi | uc001pgx.5, human |
Organism-specific databases
CTDi | 330 |
DisGeNETi | 330 |
GeneCardsi | BIRC3 |
HGNCi | HGNC:591, BIRC3 |
HPAi | ENSG00000023445, Tissue enhanced (intestine, lymphoid tissue) |
MalaCardsi | BIRC3 |
MIMi | 601721, gene |
neXtProti | NX_Q13489 |
OpenTargetsi | ENSG00000023445 |
Orphaneti | 52417, MALT lymphoma |
PharmGKBi | PA25360 |
VEuPathDBi | HostDB:ENSG00000023445.13 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1101, Eukaryota |
GeneTreei | ENSGT00940000154175 |
HOGENOMi | CLU_016347_1_1_1 |
InParanoidi | Q13489 |
OMAi | SPIIHFG |
OrthoDBi | 1340284at2759 |
PhylomeDBi | Q13489 |
TreeFami | TF105356 |
Enzyme and pathway databases
PathwayCommonsi | Q13489 |
Reactomei | R-HSA-168638, NOD1/2 Signaling Pathway R-HSA-168927, TICAM1, RIP1-mediated IKK complex recruitment R-HSA-5213460, RIPK1-mediated regulated necrosis R-HSA-5357905, Regulation of TNFR1 signaling R-HSA-5357956, TNFR1-induced NFkappaB signaling pathway R-HSA-5668541, TNFR2 non-canonical NF-kB pathway R-HSA-5675482, Regulation of necroptotic cell death R-HSA-5676594, TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway R-HSA-5689880, Ub-specific processing proteases R-HSA-937041, IKK complex recruitment mediated by RIP1 |
SignaLinki | Q13489 |
SIGNORi | Q13489 |
Miscellaneous databases
BioGRID-ORCSi | 330, 10 hits in 880 CRISPR screens |
ChiTaRSi | BIRC3, human |
EvolutionaryTracei | Q13489 |
GeneWikii | Baculoviral_IAP_repeat-containing_protein_3 |
GenomeRNAii | 330 |
Pharosi | Q13489, Tchem |
PROi | PR:Q13489 |
RNActi | Q13489, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000023445, Expressed in tonsil and 194 other tissues |
ExpressionAtlasi | Q13489, baseline and differential |
Genevisiblei | Q13489, HS |
Family and domain databases
CDDi | cd00022, BIR, 3 hits |
InterProi | View protein in InterPro IPR001370, BIR_rpt IPR001315, CARD IPR011029, DEATH-like_dom_sf IPR001841, Znf_RING |
Pfami | View protein in Pfam PF00653, BIR, 3 hits PF00619, CARD, 1 hit |
SMARTi | View protein in SMART SM00238, BIR, 3 hits SM00114, CARD, 1 hit SM00184, RING, 1 hit |
SUPFAMi | SSF47986, SSF47986, 1 hit |
PROSITEi | View protein in PROSITE PS01282, BIR_REPEAT_1, 3 hits PS50143, BIR_REPEAT_2, 3 hits PS50209, CARD, 1 hit PS50089, ZF_RING_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | BIRC3_HUMAN | |
Accessioni | Q13489Primary (citable) accession number: Q13489 Secondary accession number(s): Q16628, Q9HC27, Q9UP46 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | November 1, 1997 | |
Last modified: | February 10, 2021 | |
This is version 209 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families