TCIRG1

Functionⁱ

Part of the proton channel of V-ATPases (By similarity). Seems to be directly involved in T-cell activation.By similarity

GO - Molecular functionⁱ

ATPase binding Source: GO_Central
proton-transporting ATPase activity, rotational mechanism Source: GO_Central
transporter activity
Source: ProtInc
Traceable author statementⁱ
- 8579597

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

ATP hydrolysis coupled proton transport Source: InterPro
ATP synthesis coupled proton transport Source: GO_Central
cellular defense response
Source: ProtInc
Traceable author statementⁱ
- 9806637
insulin receptor signaling pathway Source: Reactome
ion transmembrane transport Source: Reactome
macroautophagy Source: ParkinsonsUK-UCL
neutrophil degranulation Source: Reactome
positive regulation of cell proliferation
Source: ProtInc
Traceable author statementⁱ
- 9806637
protein catabolic process in the vacuole Source: ParkinsonsUK-UCL
proton transmembrane transport
Source: ProtInc
Traceable author statementⁱ
- 8579597
transferrin transport Source: Reactome
vacuolar acidification Source: GO_Central
vacuolar proton-transporting V-type ATPase complex assembly Source: GO_Central

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Hydrogen ion transport, Ion transport, Transport

Biological process

Hydrogen ion transport, Ion transport, Transport

Enzyme and pathway databases

BioCycⁱ	MetaCyc:ENSG00000110719-MONOMER
Reactomeⁱ	R-HSA-1222556 ROS, RNS production in phagocytes R-HSA-6798695 Neutrophil degranulation R-HSA-77387 Insulin receptor recycling R-HSA-917977 Transferrin endocytosis and recycling R-HSA-983712 Ion channel transport

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: V-type proton ATPase 116 kDa subunit a isoform 3 Short name: V-ATPase 116 kDa isoform a3 Alternative name(s): Osteoclastic proton pump 116 kDa subunit Short name: OC-116 kDa Short name: OC116 T-cell immune regulator 1 T-cell immune response cDNA7 protein Short name: TIRC7 Vacuolar proton translocating ATPase 116 kDa subunit a isoform 3
Gene namesⁱ	Name:TCIRG1 Synonyms:ATP6N1C, ATP6V0A3
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 11

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000110719.9
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:11647 TCIRG1
MIMⁱ	604592 gene
neXtProtⁱ	NX_Q13488

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 385	CytoplasmicSequence analysisAdd BLAST	385
Transmembraneⁱ	386 – 404	HelicalSequence analysisAdd BLAST	19
Topological domainⁱ	405 – 406	VacuolarSequence analysis	2
Transmembraneⁱ	407 – 423	HelicalSequence analysisAdd BLAST	17
Topological domainⁱ	424 – 438	CytoplasmicSequence analysisAdd BLAST	15
Transmembraneⁱ	439 – 468	HelicalSequence analysisAdd BLAST	30
Topological domainⁱ	469 – 532	VacuolarSequence analysisAdd BLAST	64
Transmembraneⁱ	533 – 552	HelicalSequence analysisAdd BLAST	20
Topological domainⁱ	553 – 570	CytoplasmicSequence analysisAdd BLAST	18
Transmembraneⁱ	571 – 591	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	592 – 635	VacuolarSequence analysisAdd BLAST	44
Transmembraneⁱ	636 – 655	HelicalSequence analysisAdd BLAST	20
Topological domainⁱ	656 – 720	CytoplasmicSequence analysisAdd BLAST	65
Transmembraneⁱ	721 – 745	HelicalSequence analysisAdd BLAST	25
Topological domainⁱ	746 – 766	VacuolarSequence analysisAdd BLAST	21
Transmembraneⁱ	767 – 807	HelicalSequence analysisAdd BLAST	41
Topological domainⁱ	808 – 830	CytoplasmicSequence analysisAdd BLAST	23

Keywords - Cellular componentⁱ

Membrane

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Osteopetrosis, autosomal recessive 1 (OPTB1)3 Publications

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA rare genetic disease characterized by abnormally dense bone, due to defective resorption of immature bone. Osteopetrosis occurs in two forms: a severe autosomal recessive form occurring in utero, infancy, or childhood, and a benign autosomal dominant form occurring in adolescence or adulthood. Recessive osteopetrosis commonly manifests in early infancy with macrocephaly, feeding difficulties, evolving blindness and deafness, bone marrow failure, severe anemia, and hepatosplenomegaly. Deafness and blindness are generally thought to represent effects of pressure on nerves.

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_020988	141	A → P in OPTB1. 1 Publication	1
Natural variantⁱVAR_019569	405	G → R in OPTB1. 3 PublicationsCorresponds to variant dbSNP:rs137853150EnsemblClinVar.	1
Natural variantⁱVAR_019570	444	R → L in OPTB1. 1 PublicationCorresponds to variant dbSNP:rs137853151EnsemblClinVar.	1
Natural variantⁱVAR_020989	462	Missing in OPTB1. 1 Publication	1
Natural variantⁱVAR_020990	517	D → N in OPTB1. 1 PublicationCorresponds to variant dbSNP:rs369264588Ensembl.	1
Natural variantⁱVAR_020991	775	P → R in OPTB1. 1 Publication	1

Keywords - Diseaseⁱ

Disease mutation, Osteopetrosis

Organism-specific databases

DisGeNET More...DisGeNETⁱ	10312
MalaCards human disease database More...MalaCardsⁱ	TCIRG1
MIMⁱ	259700 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000110719
Orphanetⁱ	486 Autosomal dominant severe congenital neutropenia 667 Autosomal recessive malignant osteopetrosis
PharmGKBⁱ	PA36399

Polymorphism and mutation databases

BioMutaⁱ	TCIRG1
DMDMⁱ	223634720

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000119218	1 – 830	V-type proton ATPase 116 kDa subunit a isoform 3Add BLAST		830

Proteomic databases

EPDⁱ	Q13488
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q13488
PaxDbⁱ	Q13488
PeptideAtlas More...PeptideAtlasⁱ	Q13488
PRIDEⁱ	Q13488
ProteomicsDBⁱ	59481 59482 [Q13488-2]

PTM databases

iPTMnetⁱ	Q13488
PhosphoSitePlusⁱ	Q13488

Expressionⁱ

Tissue specificityⁱ

Isoform long is highly expressed in osteoclastomas. Isoform short is highly expressed in thymus.

Gene expression databases

Bgeeⁱ	ENSG00000110719
CleanExⁱ	HS_TCIRG1
ExpressionAtlasⁱ	Q13488 baseline and differential
Genevisibleⁱ	Q13488 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA038742

HPAⁱ

HPA038742

Interactionⁱ

Subunit structureⁱ

The V-ATPase is a heteromultimeric enzyme composed of at least thirteen different subunits. It has a membrane peripheral V1 sector for ATP hydrolysis and an integral V0 for proton translocation. The V1 sector comprises subunits A-H, whereas V0 includes subunits a, d, c, c', and c''.

GO - Molecular functionⁱ

ATPase binding Source: GO_Central

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	115597, 21 interactors
IntActⁱ	Q13488, 8 interactors
STRINGⁱ	9606.ENSP00000265686

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q13488
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the V-ATPase 116 kDa subunit family.Curated

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG2189 Eukaryota COG1269 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000004941
HOGENOMⁱ	HOG000037059
HOVERGENⁱ	HBG014606
InParanoidⁱ	Q13488
KEGG Orthology (KO) More...KOⁱ	K02154
OMAⁱ	WRACRGF
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G031W
PhylomeDBⁱ	Q13488
TreeFamⁱ	TF300346

Family and domain databases

InterProⁱ	View protein in InterPro IPR002490 V-ATPase_116kDa_su IPR026028 V-type_ATPase_116kDa_su_euka
PANTHERⁱ	PTHR11629 PTHR11629, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01496 V_ATPase_I, 1 hit
PIRSFⁱ	PIRSF001293 ATP6V0A1, 1 hit

Sequences (2)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket Added to basket

Isoform Long (identifier: Q13488-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGSMFRSEEV ALVQLFLPTA AAYTCVSRLG ELGLVEFRDL NASVSAFQRR 
        60         70         80         90        100
FVVDVRRCEE LEKTFTFLQE EVRRAGLVLP PPKGRLPAPP PRDLLRIQEE 
       110        120        130        140        150
TERLAQELRD VRGNQQALRA QLHQLQLHAA VLRQGHEPQL AAAHTDGASE 
       160        170        180        190        200
RTPLLQAPGG PHQDLRVNFV AGAVEPHKAP ALERLLWRAC RGFLIASFRE 
       210        220        230        240        250
LEQPLEHPVT GEPATWMTFL ISYWGEQIGQ KIRKITDCFH CHVFPFLQQE 
       260        270        280        290        300
EARLGALQQL QQQSQELQEV LGETERFLSQ VLGRVLQLLP PGQVQVHKMK 
       310        320        330        340        350
AVYLALNQCS VSTTHKCLIA EAWCSVRDLP ALQEALRDSS MEEGVSAVAH 
       360        370        380        390        400
RIPCRDMPPT LIRTNRFTAS FQGIVDAYGV GRYQEVNPAP YTIITFPFLF 
       410        420        430        440        450
AVMFGDVGHG LLMFLFALAM VLAENRPAVK AAQNEIWQTF FRGRYLLLLM 
       460        470        480        490        500
GLFSIYTGFI YNECFSRATS IFPSGWSVAA MANQSGWSDA FLAQHTMLTL 
       510        520        530        540        550
DPNVTGVFLG PYPFGIDPIW SLAANHLSFL NSFKMKMSVI LGVVHMAFGV 
       560        570        580        590        600
VLGVFNHVHF GQRHRLLLET LPELTFLLGL FGYLVFLVIY KWLCVWAARA 
       610        620        630        640        650
ASAPSILIHF INMFLFSHSP SNRLLYPRQE VVQATLVVLA LAMVPILLLG 
       660        670        680        690        700
TPLHLLHRHR RRLRRRPADR QEENKAGLLD LPDASVNGWS SDEEKAGGLD 
       710        720        730        740        750
DEEEAELVPS EVLMHQAIHT IEFCLGCVSN TASYLRLWAL SLAHAQLSEV 
       760        770        780        790        800
LWAMVMRIGL GLGREVGVAA VVLVPIFAAF AVMTVAILLV MEGLSAFLHA 
       810        820        830
LRLHWVEFQN KFYSGTGYKL SPFTFAATDD

Length:830

Mass (Da):92,968

Last modified:February 10, 2009 - v3

Checksum:ⁱ50751B41B171D9D2

GO

Isoform Short (identifier: Q13488-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-216: Missing.

« Hide

        10         20         30         40         50
MTFLISYWGE QIGQKIRKIT DCFHCHVFPF LQQEEARLGA LQQLQQQSQE 
        60         70         80         90        100
LQEVLGETER FLSQVLGRVL QLLPPGQVQV HKMKAVYLAL NQCSVSTTHK 
       110        120        130        140        150
CLIAEAWCSV RDLPALQEAL RDSSMEEGVS AVAHRIPCRD MPPTLIRTNR 
       160        170        180        190        200
FTASFQGIVD AYGVGRYQEV NPAPYTIITF PFLFAVMFGD VGHGLLMFLF 
       210        220        230        240        250
ALAMVLAENR PAVKAAQNEI WQTFFRGRYL LLLMGLFSIY TGFIYNECFS 
       260        270        280        290        300
RATSIFPSGW SVAAMANQSG WSDAFLAQHT MLTLDPNVTG VFLGPYPFGI 
       310        320        330        340        350
DPIWSLAANH LSFLNSFKMK MSVILGVVHM AFGVVLGVFN HVHFGQRHRL 
       360        370        380        390        400
LLETLPELTF LLGLFGYLVF LVIYKWLCVW AARAASAPSI LIHFINMFLF 
       410        420        430        440        450
SHSPSNRLLY PRQEVVQATL VVLALAMVPI LLLGTPLHLL HRHRRRLRRR 
       460        470        480        490        500
PADRQEENKA GLLDLPDASV NGWSSDEEKA GGLDDEEEAE LVPSEVLMHQ 
       510        520        530        540        550
AIHTIEFCLG CVSNTASYLR LWALSLAHAQ LSEVLWAMVM RIGLGLGREV 
       560        570        580        590        600
GVAAVVLVPI FAAFAVMTVA ILLVMEGLSA FLHALRLHWV EFQNKFYSGT 
       610 
GYKLSPFTFA ATDD

Note: No experimental confirmation available.

Show »

Length:614

Mass (Da):68,776

Checksum:ⁱB493A1F9514419FE

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	377	A → R in AAA97878 (PubMed:8579597).Curated		1
Sequence conflictⁱ	603	Missing in AAA97878 (PubMed:8579597).Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_054340	56	R → W. Corresponds to variant dbSNP:rs36027301EnsemblClinVar.	1
Natural variantⁱVAR_020988	141	A → P in OPTB1. 1 Publication	1
Natural variantⁱVAR_054341	161	P → L. Corresponds to variant dbSNP:rs34227834EnsemblClinVar.	1
Natural variantⁱVAR_019569	405	G → R in OPTB1. 3 PublicationsCorresponds to variant dbSNP:rs137853150EnsemblClinVar.	1
Natural variantⁱVAR_019570	444	R → L in OPTB1. 1 PublicationCorresponds to variant dbSNP:rs137853151EnsemblClinVar.	1
Natural variantⁱVAR_020989	462	Missing in OPTB1. 1 Publication	1
Natural variantⁱVAR_020990	517	D → N in OPTB1. 1 PublicationCorresponds to variant dbSNP:rs369264588Ensembl.	1
Natural variantⁱVAR_020991	775	P → R in OPTB1. 1 Publication	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_000345	1 – 216	Missing in isoform Short. 1 PublicationAdd BLAST		216

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U45285 mRNA Translation: AAA97878.1 AF025374 mRNA Translation: AAC35742.1 AF033033 Genomic DNA Translation: AAD31081.2 CH471076 Genomic DNA Translation: EAW74691.1 BC018133 mRNA Translation: AAH18133.1 BC032465 mRNA Translation: AAH32465.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS53670.1 [Q13488-2] CCDS8177.1 [Q13488-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_006010.2, NM_006019.3 [Q13488-1] NP_006044.1, NM_006053.3 [Q13488-2] XP_005273766.1, XM_005273709.3 [Q13488-1] XP_011543028.1, XM_011544726.2 [Q13488-1]
UniGeneⁱ	Hs.495985 Hs.716672

Genome annotation databases

Ensemblⁱ	ENST00000265686; ENSP00000265686; ENSG00000110719 [Q13488-1] ENST00000532635; ENSP00000434407; ENSG00000110719 [Q13488-2]
GeneIDⁱ	10312
KEGGⁱ	hsa:10312
UCSC genome browser More...UCSCⁱ	uc001one.4 human [Q13488-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length
Q13488	V-type proton ATPase subunit a		HUMAN		830
UPI0000D4C917		HUMAN		532
Q13488-2				614

Protein	Similar proteins		Species	Score	Length
Q13488	V-type proton ATPase subunit a		HUMAN		830
V-type proton ATPase subunit a		SAIBB		845
V-type proton ATPase subunit a		MACNE		838
V-type proton ATPase subunit a		NOMLE		832
V-type proton ATPase subunit a		CHLSB		830
+37

Protein	Similar proteins		Species	Score	Length
Q13488	V-type proton ATPase subunit a		HUMAN		830
V-type proton ATPase subunit a		SAIBB		845
V-type proton ATPase subunit a		MACNE		838
V-type proton ATPase subunit a		NOMLE		832
V-type proton ATPase subunit a		COLAP		830
+62

Cross-referencesⁱ

Web resourcesⁱ

TCIRG1base

TCIRG1 mutation db

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U45285 mRNA Translation: AAA97878.1 AF025374 mRNA Translation: AAC35742.1 AF033033 Genomic DNA Translation: AAD31081.2 CH471076 Genomic DNA Translation: EAW74691.1 BC018133 mRNA Translation: AAH18133.1 BC032465 mRNA Translation: AAH32465.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS53670.1 [Q13488-2] CCDS8177.1 [Q13488-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_006010.2, NM_006019.3 [Q13488-1] NP_006044.1, NM_006053.3 [Q13488-2] XP_005273766.1, XM_005273709.3 [Q13488-1] XP_011543028.1, XM_011544726.2 [Q13488-1]
UniGeneⁱ	Hs.495985 Hs.716672

3D structure databases

ProteinModelPortalⁱ	Q13488
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	115597, 21 interactors
IntActⁱ	Q13488, 8 interactors
STRINGⁱ	9606.ENSP00000265686

PTM databases

iPTMnetⁱ	Q13488
PhosphoSitePlusⁱ	Q13488

Polymorphism and mutation databases

BioMutaⁱ	TCIRG1
DMDMⁱ	223634720

Proteomic databases

EPDⁱ	Q13488
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q13488
PaxDbⁱ	Q13488
PeptideAtlas More...PeptideAtlasⁱ	Q13488
PRIDEⁱ	Q13488
ProteomicsDBⁱ	59481 59482 [Q13488-2]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	10312
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000265686; ENSP00000265686; ENSG00000110719 [Q13488-1] ENST00000532635; ENSP00000434407; ENSG00000110719 [Q13488-2]
GeneIDⁱ	10312
KEGGⁱ	hsa:10312
UCSC genome browser More...UCSCⁱ	uc001one.4 human [Q13488-1]

Organism-specific databases

CTDⁱ	10312
DisGeNET More...DisGeNETⁱ	10312
EuPathDBⁱ	HostDB:ENSG00000110719.9
GeneCardsⁱ	TCIRG1
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:11647 TCIRG1
Human Protein Atlas More...HPAⁱ	HPA038742
MalaCards human disease database More...MalaCardsⁱ	TCIRG1
MIMⁱ	259700 phenotype 604592 gene
neXtProtⁱ	NX_Q13488
Open Targets More...OpenTargetsⁱ	ENSG00000110719
Orphanetⁱ	486 Autosomal dominant severe congenital neutropenia 667 Autosomal recessive malignant osteopetrosis
PharmGKBⁱ	PA36399
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG2189 Eukaryota COG1269 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000004941
HOGENOMⁱ	HOG000037059
HOVERGENⁱ	HBG014606
InParanoidⁱ	Q13488
KEGG Orthology (KO) More...KOⁱ	K02154
OMAⁱ	WRACRGF
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G031W
PhylomeDBⁱ	Q13488
TreeFamⁱ	TF300346

Enzyme and pathway databases

BioCycⁱ	MetaCyc:ENSG00000110719-MONOMER
Reactomeⁱ	R-HSA-1222556 ROS, RNS production in phagocytes R-HSA-6798695 Neutrophil degranulation R-HSA-77387 Insulin receptor recycling R-HSA-917977 Transferrin endocytosis and recycling R-HSA-983712 Ion channel transport

Miscellaneous databases

ChiTaRSⁱ	TCIRG1 human
GeneWikiⁱ	TCIRG1
GenomeRNAiⁱ	10312
Protein Ontology More...PROⁱ	PR:Q13488
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000110719
CleanExⁱ	HS_TCIRG1
ExpressionAtlasⁱ	Q13488 baseline and differential
Genevisibleⁱ	Q13488 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR002490 V-ATPase_116kDa_su IPR026028 V-type_ATPase_116kDa_su_euka
PANTHERⁱ	PTHR11629 PTHR11629, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01496 V_ATPase_I, 1 hit
PIRSFⁱ	PIRSF001293 ATP6V0A1, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	VPP3_HUMAN
Accessionⁱ	Q13488Primary (citable) accession number: Q13488 Secondary accession number(s): O75877, Q8WVC5
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
	Last sequence update:	February 10, 2009
	Last modified:	June 20, 2018
	This is version 175 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
SIMILARITY comments
Index of protein domains and families

UniProtKB

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Supporting data

UniProtKB - Q13488 (VPP3_HUMAN)

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V-type proton ATPase 116 kDa subunit a isoform 3

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Endosome

Lysosome

Plasma Membrane

Other locations

Topology

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

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<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

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<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ