GAB1

Functionⁱ

Adapter protein that plays a role in intracellular signaling cascades triggered by activated receptor-type kinases. Plays a role in FGFR1 signaling. Probably involved in signaling by the epidermal growth factor receptor (EGFR) and the insulin receptor (INSR). Involved in the MET/HGF-signaling pathway (PubMed:29408807).1 Publication

GO - Molecular functionⁱ

1-phosphatidylinositol-3-kinase activity Source: Reactome
phosphatidylinositol-4,5-bisphosphate 3-kinase activity Source: Reactome
SH3/SH2 adaptor activity
Source: ProtInc
Traceable author statementⁱ
- 8596638

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

actin cytoskeleton reorganization
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 17178724
angiogenesis
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 17178724
axon guidance Source: Reactome
cell proliferation
Source: ProtInc
Traceable author statementⁱ
- 8596638
endothelial cell chemotaxis to vascular endothelial growth factor
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 17178724
epidermal growth factor receptor signaling pathway Source: Reactome
ERBB2 signaling pathway Source: Reactome
insulin receptor signaling pathway
Source: ProtInc
Traceable author statementⁱ
- 8596638
positive regulation of angiogenesis
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 25217442
positive regulation of cell migration by vascular endothelial growth factor signaling pathway Source: BHF-UCL
positive regulation of protein kinase B signaling Source: Reactome
response to hepatocyte growth factor Source: Ensembl
vascular endothelial growth factor signaling pathway
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 17178724

View the complete GO annotation on QuickGO ...

Enzyme and pathway databases

Reactomeⁱ	R-HSA-109704 PI3K Cascade R-HSA-1236382 Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1257604 PIP3 activates AKT signaling R-HSA-180292 GAB1 signalosome R-HSA-1963642 PI3K events in ERBB2 signaling R-HSA-2219530 Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-5637810 Constitutive Signaling by EGFRvIII R-HSA-5654689 PI-3K cascade:FGFR1 R-HSA-5654695 PI-3K cascade:FGFR2 R-HSA-5654710 PI-3K cascade:FGFR3 R-HSA-5654720 PI-3K cascade:FGFR4 R-HSA-5655253 Signaling by FGFR2 in disease R-HSA-5655291 Signaling by FGFR4 in disease R-HSA-5655302 Signaling by FGFR1 in disease R-HSA-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-8851907 MET activates PI3K/AKT signaling R-HSA-8853334 Signaling by FGFR3 fusions in cancer R-HSA-8853338 Signaling by FGFR3 point mutants in cancer R-HSA-8853659 RET signaling R-HSA-8865999 MET activates PTPN11 R-HSA-8875555 MET activates RAP1 and RAC1 R-HSA-8875656 MET receptor recycling R-HSA-9028335 Activated NTRK2 signals through PI3K
SignaLinkⁱ	Q13480
SIGNORⁱ	Q13480

Protein family/group databases

MoonDBⁱ	Q13480 Predicted

MoonDBⁱ

Q13480 Predicted

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: GRB2-associated-binding protein 1 Alternative name(s): GRB2-associated binder 1 Growth factor receptor bound protein 2-associated protein 1
Gene namesⁱ	Name:GAB1
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 4

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000109458.8
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:4066 GAB1
MIMⁱ	604439 gene
neXtProtⁱ	NX_Q13480

Subcellular locationⁱ

GO - Cellular component

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Deafness, autosomal recessive, 26 (DFNB26)1 Publication

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA form of non-syndromic sensorineural deafness characterized by prelingual, severe to profound hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_080809	116	G → E in DFNB26; results in dysregulation of MET-signaling pathway genes expression; does not affect interaction with METTL13. 1 Publication		1

Keywords - Diseaseⁱ

Deafness, Disease mutation, Non-syndromic deafness

Organism-specific databases

DisGeNET More...DisGeNETⁱ	2549
MalaCards human disease database More...MalaCardsⁱ	GAB1
MIMⁱ	605428 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000109458
PharmGKBⁱ	PA28477

Polymorphism and mutation databases

BioMutaⁱ	GAB1
DMDMⁱ	90180201

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Initiator methionineⁱ		RemovedCombined sources
ChainⁱPRO_0000050282	2 – 694	GRB2-associated-binding protein 1Add BLAST		693

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	2	N-acetylserineCombined sources	1
Modified residueⁱ	251	PhosphoserineCombined sources	1
Modified residueⁱ	253	PhosphoserineCombined sources	1
Modified residueⁱ	266	PhosphoserineCombined sources	1
Modified residueⁱ	304	PhosphoserineCombined sources	1
Modified residueⁱ	387	PhosphothreonineCombined sources	1
Modified residueⁱ	402	PhosphoserineCombined sources	1
Modified residueⁱ	454	PhosphoserineBy similarity	1
Modified residueⁱ	627	PhosphotyrosineCombined sources	1
Modified residueⁱ	638	PhosphothreonineCombined sources	1
Modified residueⁱ	651	PhosphoserineCombined sources	1
Modified residueⁱ	659	PhosphotyrosineCombined sources	1
Modified residueⁱ	683	PhosphoserineCombined sources	1
Isoform 2 (identifier: Q13480-2)
Modified residueⁱ	547	PhosphoserineCombined sources	1

Post-translational modificationⁱ

Phosphorylated in response to FGFR1 activation. Phosphorylated on tyrosine residue(s) by the epidermal growth factor receptor (EGFR) and the insulin receptor (INSR). Tyrosine phosphorylation of GAB1 mediates interaction with several proteins that contain SH2 domains. Phosphorylated on tyrosine residues by HCK upon IL6 signaling.1 Publication

Keywords - PTMⁱ

Acetylation, Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q13480
PaxDbⁱ	Q13480
PeptideAtlas More...PeptideAtlasⁱ	Q13480
PRIDEⁱ	Q13480
ProteomicsDBⁱ	59477 59478 [Q13480-2]

PTM databases

iPTMnetⁱ	Q13480
PhosphoSitePlusⁱ	Q13480

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000109458 Expressed in 218 organ(s), highest expression level in corpus callosum
CleanExⁱ	HS_GAB1
ExpressionAtlasⁱ	Q13480 baseline and differential
Genevisibleⁱ	Q13480 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB034333 HPA049599

HPAⁱ

CAB034333
HPA049599

Interactionⁱ

Subunit structureⁱ

Interacts with GRB2 and with other SH2-containing proteins (PubMed:15010462). Interacts with phosphorylated LAT2 (PubMed:12486104). Interacts with PTPRJ (PubMed:12475979). Identified in a complex containing FRS2, GRB2, GAB1, PIK3R1 and SOS1. Interacts (phosphorylated) with PTPN11 (PubMed:15010462). Interacts with HCK (PubMed:15010462). Part of a tripartite complex containing GAB1, METTL13 and SPRY2 (PubMed:29408807). Interacts with METTL13 (PubMed:29408807).4 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
BLK	P51451	3	EBI-517684,EBI-2105445
CRK	P46108	2	EBI-517684,EBI-886
CRKL	P46109	4	EBI-517684,EBI-910
EGFR	P00533	3	EBI-517684,EBI-297353
FES	P07332	2	EBI-517684,EBI-1055635
GRB2	P62993	5	EBI-517684,EBI-401755
GTF2A1L	Q9UNN4	3	EBI-517684,EBI-10229384
INPPL1	O15357	2	EBI-517684,EBI-1384248
LCK	P06239	10	EBI-517684,EBI-1348
LYN	P07948	7	EBI-517684,EBI-79452
NCK1	P16333	3	EBI-517684,EBI-389883
NCK2	O43639	5	EBI-517684,EBI-713635
PIK3R1	P27986	33	EBI-517684,EBI-79464
PIK3R2	O00459	23	EBI-517684,EBI-346930
PIK3R3	Q92569	36	EBI-517684,EBI-79893
PLCG1	P19174	36	EBI-517684,EBI-79387
PLCG2	P16885	15	EBI-517684,EBI-617403
PTK6	Q13882	6	EBI-517684,EBI-1383632
PTPN11	Q06124	39	EBI-517684,EBI-297779
PTPRJ	Q12913	2	EBI-517684,EBI-2264500
PXN	P49023	2	EBI-517684,EBI-702209
RASA1	P20936	25	EBI-517684,EBI-1026476
SH2D1B	O14796	8	EBI-517684,EBI-3923013
SH2D2A	Q9NP31	6	EBI-517684,EBI-490630
SHC1	P29353	9	EBI-517684,EBI-78835
SLA2	Q9H6Q3	4	EBI-517684,EBI-1222854
SOCS3	O14543	4	EBI-517684,EBI-714146
SOCS6	O14544	9	EBI-517684,EBI-3929549
SRC	P12931	12	EBI-517684,EBI-621482
STAP1	Q9ULZ2	3	EBI-517684,EBI-6083058
SYK	P43405	4	EBI-517684,EBI-78302
TEC	P42680	2	EBI-517684,EBI-1383480
VAV1	P15498	2	EBI-517684,EBI-625518
VAV2	P52735	2	EBI-517684,EBI-297549
VAV3	Q9UKW4	6	EBI-517684,EBI-297568
YES1	P07947	7	EBI-517684,EBI-515331

GO - Molecular functionⁱ

SH3/SH2 adaptor activity
Source: ProtInc
Traceable author statementⁱ
- 8596638

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	108824, 34 interactors
CORUMⁱ	Q13480
ELMⁱ	Q13480
IntActⁱ	Q13480, 62 interactors
Molecular INTeraction database More...MINTⁱ	Q13480
STRINGⁱ	9606.ENSP00000262995

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q13480
SMRⁱ	Q13480
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	5 – 116	PHPROSITE-ProRule annotationAdd BLAST		112

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	449 – 540	Pro-richAdd BLAST		92

Sequence similaritiesⁱ

Belongs to the GAB family.Curated

Phylogenomic databases

eggNOGⁱ	ENOG410IEIX Eukaryota ENOG4111RDE LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00510000046662
HOGENOMⁱ	HOG000236270
HOVERGENⁱ	HBG051685
InParanoidⁱ	Q13480
KEGG Orthology (KO) More...KOⁱ	K09593
OMAⁱ	CSITRTA
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G03BY
PhylomeDBⁱ	Q13480
TreeFamⁱ	TF329487

Family and domain databases

Gene3Dⁱ	2.30.29.30, 1 hit
InterProⁱ	View protein in InterPro IPR011993 PH-like_dom_sf IPR001849 PH_domain
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00169 PH, 1 hit
SMARTⁱ	View protein in SMART SM00233 PH, 1 hit
PROSITEⁱ	View protein in PROSITE PS50003 PH_DOMAIN, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 6 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q13480-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSGGEVVCSG WLRKSPPEKK LKRYAWKRRW FVLRSGRLTG DPDVLEYYKN 
        60         70         80         90        100
DHAKKPIRII DLNLCQQVDA GLTFNKKEFE NSYIFDINTI DRIFYLVADS 
       110        120        130        140        150
EEEMNKWVRC ICDICGFNPT EEDPVKPPGS SLQAPADLPL AINTAPPSTQ 
       160        170        180        190        200
ADSSSATLPP PYQLINVPPH LETLGIQEDP QDYLLLINCQ SKKPEPTRTH 
       210        220        230        240        250
ADSAKSTSSE TDCNDNVPSH KNPASSQSKH GMNGFFQQQM IYDSPPSRAP 
       260        270        280        290        300
SASVDSSLYN LPRSYSHDVL PKVSPSSTEA DGELYVFNTP SGTSSVETQM 
       310        320        330        340        350
RHVSISYDIP PTPGNTYQIP RTFPEGTLGQ TSKLDTIPDI PPPRPPKPHP 
       360        370        380        390        400
AHDRSPVETC SIPRTASDTD SSYCIPTAGM SPSRSNTIST VDLNKLRKDA 
       410        420        430        440        450
SSQDCYDIPR AFPSDRSSSL EGFHNHFKVK NVLTVGSVSS EELDENYVPM 
       460        470        480        490        500
NPNSPPRQHS SSFTEPIQEA NYVPMTPGTF DFSSFGMQVP PPAHMGFRSS 
       510        520        530        540        550
PKTPPRRPVP VADCEPPPVD RNLKPDRKVK PAPLEIKPLP EWEELQAPVR 
       560        570        580        590        600
SPITRSFARD SSRFPMSPRP DSVHSTTSSS DSHDSEENYV PMNPNLSSED 
       610        620        630        640        650
PNLFGSNSLD GGSSPMIKPK GDKQVEYLDL DLDSGKSTPP RKQKSSGSGS 
       660        670        680        690 
SVADERVDYV VVDQQKTLAL KSTREAWTDG RQSTESETPA KSVK

Length:694

Mass (Da):76,616

Last modified:February 7, 2006 - v2

Checksum:ⁱE0FAC78772B6677B

GO

Isoform 2 (identifier: Q13480-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
528-528: K → KGQSPKILRLKPHGLERTDSQTIGDFATRRK

« Hide

        10         20         30         40         50
MSGGEVVCSG WLRKSPPEKK LKRYAWKRRW FVLRSGRLTG DPDVLEYYKN 
        60         70         80         90        100
DHAKKPIRII DLNLCQQVDA GLTFNKKEFE NSYIFDINTI DRIFYLVADS 
       110        120        130        140        150
EEEMNKWVRC ICDICGFNPT EEDPVKPPGS SLQAPADLPL AINTAPPSTQ 
       160        170        180        190        200
ADSSSATLPP PYQLINVPPH LETLGIQEDP QDYLLLINCQ SKKPEPTRTH 
       210        220        230        240        250
ADSAKSTSSE TDCNDNVPSH KNPASSQSKH GMNGFFQQQM IYDSPPSRAP 
       260        270        280        290        300
SASVDSSLYN LPRSYSHDVL PKVSPSSTEA DGELYVFNTP SGTSSVETQM 
       310        320        330        340        350
RHVSISYDIP PTPGNTYQIP RTFPEGTLGQ TSKLDTIPDI PPPRPPKPHP 
       360        370        380        390        400
AHDRSPVETC SIPRTASDTD SSYCIPTAGM SPSRSNTIST VDLNKLRKDA 
       410        420        430        440        450
SSQDCYDIPR AFPSDRSSSL EGFHNHFKVK NVLTVGSVSS EELDENYVPM 
       460        470        480        490        500
NPNSPPRQHS SSFTEPIQEA NYVPMTPGTF DFSSFGMQVP PPAHMGFRSS 
       510        520        530        540        550
PKTPPRRPVP VADCEPPPVD RNLKPDRKGQ SPKILRLKPH GLERTDSQTI 
       560        570        580        590        600
GDFATRRKVK PAPLEIKPLP EWEELQAPVR SPITRSFARD SSRFPMSPRP 
       610        620        630        640        650
DSVHSTTSSS DSHDSEENYV PMNPNLSSED PNLFGSNSLD GGSSPMIKPK 
       660        670        680        690        700
GDKQVEYLDL DLDSGKSTPP RKQKSSGSGS SVADERVDYV VVDQQKTLAL 
       710        720 
KSTREAWTDG RQSTESETPA KSVK

Show »

Length:724

Mass (Da):80,005

Checksum:ⁱEAA4573B9E5A25B9

GO

Computationally mapped potential isoform sequencesⁱ

There are 6 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

H0Y8F4	H0Y8F4_HUMAN	GRB2-associated-binding protein 1 GRB2-associated-binding protein 1	GAB1	94	Annotation score:
D6RIF8	D6RIF8_HUMAN	GRB2-associated-binding protein 1 GRB2-associated-binding protein 1	GAB1	176	Annotation score:
D6RIS0	D6RIS0_HUMAN	GRB2-associated-binding protein 1 GRB2-associated-binding protein 1	GAB1	239	Annotation score:
B7Z3B9	B7Z3B9_HUMAN	cDNA FLJ53999, highly similar to GR... cDNA FLJ53999, highly similar to GRB2-associated-binding protein 1	GAB1	591	Annotation score:
D6RF42	D6RF42_HUMAN	GRB2-associated-binding protein 1 GRB2-associated-binding protein 1	GAB1	48	Annotation score:
H0YA71	H0YA71_HUMAN	GRB2-associated-binding protein 1 GRB2-associated-binding protein 1	GAB1	91	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	204	A → G in AAC50380 (PubMed:8596638).Curated		1
Sequence conflictⁱ	213	C → S in AAC50380 (PubMed:8596638).Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_036132	83	Y → C in a breast cancer sample; somatic mutation. 1 Publication	1
Natural variantⁱVAR_080809	116	G → E in DFNB26; results in dysregulation of MET-signaling pathway genes expression; does not affect interaction with METTL13. 1 Publication	1
Natural variantⁱVAR_025261	311	P → L1 PublicationCorresponds to variant dbSNP:rs28925904Ensembl.	1
Natural variantⁱVAR_053096	377	T → I. Corresponds to variant dbSNP:rs2229879Ensembl.	1
Natural variantⁱVAR_036133	387	T → N in a breast cancer sample; somatic mutation. 1 Publication	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_017137	528	K → KGQSPKILRLKPHGLERTDS QTIGDFATRRK in isoform 2. 1 Publication		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U43885 mRNA Translation: AAC50380.1 DQ021880 Genomic DNA Translation: AAY26398.1 AK289767 mRNA Translation: BAF82456.1 AC097658 Genomic DNA No translation available. AC104685 Genomic DNA Translation: AAY40964.1 CH471056 Genomic DNA Translation: EAX05072.1 BC064848 mRNA Translation: AAH64848.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS3759.1 [Q13480-1] CCDS3760.1 [Q13480-2]
PIRⁱ	S68442
NCBI Reference Sequences More...RefSeqⁱ	NP_002030.2, NM_002039.3 [Q13480-1] NP_997006.1, NM_207123.2 [Q13480-2]
UniGeneⁱ	Hs.618456 Hs.80720

Genome annotation databases

Ensemblⁱ	ENST00000262994; ENSP00000262994; ENSG00000109458 [Q13480-1] ENST00000262995; ENSP00000262995; ENSG00000109458 [Q13480-2]
GeneIDⁱ	2549
KEGGⁱ	hsa:2549
UCSC genome browser More...UCSCⁱ	uc003ijd.4 human [Q13480-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Protein	Similar proteins		Species	Score	Length	Source
Q13480	cDNA FLJ53999, highly similar to GRB2-associated-binding protein 1		HUMAN		591	UniRef100_Q13480

Protein	Similar proteins		Species	Score	Length	Source
Q13480	GRB2-associated-binding protein 1		BOVIN		694	UniRef90_Q13480
cDNA FLJ53999, highly similar to GRB2-associated-binding protein 1		HUMAN		591
GRB2-associated-binding protein 1		FUKDA		750
GRB2-associated-binding protein 1		CRIGR		696
Uncharacterized protein		OTOGA		695
+96
Q13480-2	GRB2-associated-binding protein 1 isoform X3		PHYCD		758	UniRef90_Q13480-2
GRB2-associated-binding protein 1 isoform X1		DELLE		757
GRB2-associated-binding protein 1		PTEAL		738
GAB1 isoform 1		PANTR		724
Uncharacterized protein		CALJA		724
+107

Protein	Similar proteins		Species	Score	Length	Source
Q13480	GRB2-associated-binding protein 1		BOVIN		694	UniRef50_Q13480
GRB2-associated-binding protein 1		MESAU		694
GRB2-associated-binding protein 1		MOUSE		695
cDNA FLJ53999, highly similar to GRB2-associated-binding protein 1		HUMAN		591
GRB2-associated-binding protein 1		FUKDA		750
+493

Cross-referencesⁱ

Web resourcesⁱ

NIEHS-SNPs

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U43885 mRNA Translation: AAC50380.1 DQ021880 Genomic DNA Translation: AAY26398.1 AK289767 mRNA Translation: BAF82456.1 AC097658 Genomic DNA No translation available. AC104685 Genomic DNA Translation: AAY40964.1 CH471056 Genomic DNA Translation: EAX05072.1 BC064848 mRNA Translation: AAH64848.1
CCDSⁱ	CCDS3759.1 [Q13480-1] CCDS3760.1 [Q13480-2]
PIRⁱ	S68442
RefSeqⁱ	NP_002030.2, NM_002039.3 [Q13480-1] NP_997006.1, NM_207123.2 [Q13480-2]
UniGeneⁱ	Hs.618456 Hs.80720

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	4QSY	X-ray	2.10	B	621-633	[»]
ProteinModelPortalⁱ	Q13480
SMRⁱ	Q13480
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	108824, 34 interactors
CORUMⁱ	Q13480
ELMⁱ	Q13480
IntActⁱ	Q13480, 62 interactors
MINTⁱ	Q13480
STRINGⁱ	9606.ENSP00000262995

Protein family/group databases

MoonDBⁱ	Q13480 Predicted

MoonDBⁱ

Q13480 Predicted

PTM databases

iPTMnetⁱ	Q13480
PhosphoSitePlusⁱ	Q13480

Polymorphism and mutation databases

BioMutaⁱ	GAB1
DMDMⁱ	90180201

Proteomic databases

MaxQBⁱ	Q13480
PaxDbⁱ	Q13480
PeptideAtlasⁱ	Q13480
PRIDEⁱ	Q13480
ProteomicsDBⁱ	59477 59478 [Q13480-2]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	2549
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000262994; ENSP00000262994; ENSG00000109458 [Q13480-1] ENST00000262995; ENSP00000262995; ENSG00000109458 [Q13480-2]
GeneIDⁱ	2549
KEGGⁱ	hsa:2549
UCSCⁱ	uc003ijd.4 human [Q13480-1]

Organism-specific databases

CTDⁱ	2549
DisGeNETⁱ	2549
EuPathDBⁱ	HostDB:ENSG00000109458.8
GeneCardsⁱ	GAB1
H-InvDBⁱ	HIX0004529
HGNCⁱ	HGNC:4066 GAB1
HPAⁱ	CAB034333 HPA049599
MalaCardsⁱ	GAB1
MIMⁱ	604439 gene 605428 phenotype
neXtProtⁱ	NX_Q13480
OpenTargetsⁱ	ENSG00000109458
PharmGKBⁱ	PA28477
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IEIX Eukaryota ENOG4111RDE LUCA
GeneTreeⁱ	ENSGT00510000046662
HOGENOMⁱ	HOG000236270
HOVERGENⁱ	HBG051685
InParanoidⁱ	Q13480
KOⁱ	K09593
OMAⁱ	CSITRTA
OrthoDBⁱ	EOG091G03BY
PhylomeDBⁱ	Q13480
TreeFamⁱ	TF329487

Enzyme and pathway databases

Reactomeⁱ	R-HSA-109704 PI3K Cascade R-HSA-1236382 Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1257604 PIP3 activates AKT signaling R-HSA-180292 GAB1 signalosome R-HSA-1963642 PI3K events in ERBB2 signaling R-HSA-2219530 Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-5637810 Constitutive Signaling by EGFRvIII R-HSA-5654689 PI-3K cascade:FGFR1 R-HSA-5654695 PI-3K cascade:FGFR2 R-HSA-5654710 PI-3K cascade:FGFR3 R-HSA-5654720 PI-3K cascade:FGFR4 R-HSA-5655253 Signaling by FGFR2 in disease R-HSA-5655291 Signaling by FGFR4 in disease R-HSA-5655302 Signaling by FGFR1 in disease R-HSA-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-8851907 MET activates PI3K/AKT signaling R-HSA-8853334 Signaling by FGFR3 fusions in cancer R-HSA-8853338 Signaling by FGFR3 point mutants in cancer R-HSA-8853659 RET signaling R-HSA-8865999 MET activates PTPN11 R-HSA-8875555 MET activates RAP1 and RAC1 R-HSA-8875656 MET receptor recycling R-HSA-9028335 Activated NTRK2 signals through PI3K
SignaLinkⁱ	Q13480
SIGNORⁱ	Q13480

Miscellaneous databases

ChiTaRSⁱ	GAB1 human
GeneWikiⁱ	GAB1
GenomeRNAiⁱ	2549
Protein Ontology More...PROⁱ	PR:Q13480
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000109458 Expressed in 218 organ(s), highest expression level in corpus callosum
CleanExⁱ	HS_GAB1
ExpressionAtlasⁱ	Q13480 baseline and differential
Genevisibleⁱ	Q13480 HS

Family and domain databases

Gene3Dⁱ	2.30.29.30, 1 hit
InterProⁱ	View protein in InterPro IPR011993 PH-like_dom_sf IPR001849 PH_domain
Pfamⁱ	View protein in Pfam PF00169 PH, 1 hit
SMARTⁱ	View protein in SMART SM00233 PH, 1 hit
PROSITEⁱ	View protein in PROSITE PS50003 PH_DOMAIN, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	GAB1_HUMAN
Accessionⁱ	Q13480Primary (citable) accession number: Q13480 Secondary accession number(s): A8K152, Q4W5G2, Q6P1W2
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	April 13, 2004
	Last sequence update:	February 7, 2006
	Last modified:	November 7, 2018
	This is version 171 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 4
Human chromosome 4: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

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UniProtKB - Q13480 (GAB1_HUMAN)

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GRB2-associated-binding protein 1

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ