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Protein

Interleukin-18 receptor 1

Gene

IL18R1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Within the IL18 receptor complex, responsible for the binding of the proinflammatory cytokine IL18, but not IL1A nor IL1B (PubMed:8626725, PubMed:14528293, PubMed:25261253, PubMed:25500532). Involved in IL18-mediated IFNG synthesis from T-helper 1 (Th1) cells (PubMed:10653850). Contributes to IL18-induced cytokine production, either independently of SLC12A3, or as a complex with SLC12A3 (By similarity).By similarity5 Publications

GO - Molecular functioni

  • interleukin-18 binding Source: UniProtKB
  • interleukin-18 receptor activity Source: Ensembl
  • interleukin-1 receptor activity Source: InterPro
  • signaling receptor activity Source: ProtInc

GO - Biological processi

Keywordsi

Molecular functionReceptor
Biological processInflammatory response

Enzyme and pathway databases

ReactomeiR-HSA-9008059 Interleukin-37 signaling
R-HSA-9012546 Interleukin-18 signaling
SIGNORiQ13478

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-18 receptor 1
Short name:
IL-18R-1
Short name:
IL-18R1
Alternative name(s):
CD218 antigen-like family member A
CDw218a
IL1 receptor-related protein
Short name:
IL-1Rrp
Short name:
IL1R-rp
Interleukin-18 receptor alpha4 Publications
Short name:
IL-18R-alpha
Short name:
IL-18Ralpha4 Publications
CD_antigen: CD218a
Gene namesi
Name:IL18R1Imported
Synonyms:IL1RRP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000115604.10
HGNCiHGNC:5988 IL18R1
MIMi604494 gene
neXtProtiNX_Q13478

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini22 – 329ExtracellularSequence analysisAdd BLAST308
Transmembranei330 – 350HelicalSequence analysisAdd BLAST21
Topological domaini351 – 541CytoplasmicSequence analysisAdd BLAST191

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi297N → Q: Decreases the affinity for IL18 suggesting that the N-linked glycosylation contributes to ligand recognition. 1 Publication1

Organism-specific databases

DisGeNETi8809
OpenTargetsiENSG00000115604
PharmGKBiPA29804

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 181 PublicationAdd BLAST18
ChainiPRO_000001544819 – 541Interleukin-18 receptor 1Add BLAST523

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi22 ↔ 41Combined sources2 Publications
Disulfide bondi43 ↔ 81Combined sources2 Publications
Glycosylationi91N-linked (GlcNAc...) asparagineCombined sources1 Publication1
Glycosylationi102N-linked (GlcNAc...) asparagineCombined sources1 Publication1
Disulfide bondi119 ↔ 158Combined sources2 Publications
Disulfide bondi140 ↔ 185PROSITE-ProRule annotationCombined sources2 Publications
Glycosylationi150N-linked (GlcNAc...) asparagineCombined sources1 Publication1
Glycosylationi197N-linked (GlcNAc...) asparagineCombined sources2 Publications1
Glycosylationi203N-linked (GlcNAc...) asparagineCombined sources2 Publications1
Glycosylationi236N-linked (GlcNAc...) asparagineCombined sources2 Publications1
Disulfide bondi237 ↔ 298PROSITE-ProRule annotationCombined sources2 Publications
Glycosylationi255N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi297N-linked (GlcNAc...) asparagineCombined sources2 Publications1

Post-translational modificationi

N-glycosylated. N-linked glycosyl chains contribute to ligand recognition and intra-receptor interactions required for formation of an active ternary receptor complex.2 Publications

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiQ13478
MaxQBiQ13478
PaxDbiQ13478
PeptideAtlasiQ13478
PRIDEiQ13478
ProteomicsDBi59476

PTM databases

iPTMnetiQ13478
PhosphoSitePlusiQ13478

Expressioni

Tissue specificityi

Highly expressed in leukocytes, spleen, lung. Also expressed, but at lower levels, in liver, small intestine, colon, prostate, thymus, placenta, and heart. Specifically coexpressed with IL18R1 in Th1 cells (PubMed:10925275, PubMed:11046021, PubMed:10653850).4 Publications

Inductioni

Induced by IL12/interleukin-12 in T-cells. Proposed to be a phenotypic marker for T-helper 1 (Th1) cells.2 Publications

Gene expression databases

BgeeiENSG00000115604 Expressed in 131 organ(s), highest expression level in right lung
CleanExiHS_IL18R1
ExpressionAtlasiQ13478 baseline and differential
GenevisibleiQ13478 HS

Organism-specific databases

HPAiHPA007615

Interactioni

Subunit structurei

Forms a ternary complex with IL18 and IL18RAP (PubMed:14528293, PubMed:25500532). Within this complex, IL18R1 is involved in ligand-binding and IL18RAP in signaling leading to NF-kappa-B and JNK activation (Probable). Interacts with SLC12A3 in peritoneal macrophages; this interaction is increased by IL18 treatment (By similarity).By similarityCurated2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
IL18Q141162EBI-9817499,EBI-3910835

GO - Molecular functioni

Protein-protein interaction databases

BioGridi114337, 2 interactors
IntActiQ13478, 1 interactor
MINTiQ13478
STRINGi9606.ENSP00000233957

Structurei

Secondary structure

1541
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ13478
SMRiQ13478
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini33 – 121Ig-like C2-type 1Add BLAST89
Domaini133 – 212Ig-like C2-type 2Add BLAST80
Domaini220 – 312Ig-like C2-type 3Add BLAST93
Domaini373 – 523TIRPROSITE-ProRule annotationAdd BLAST151

Sequence similaritiesi

Belongs to the interleukin-1 receptor family.Curated

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IH1W Eukaryota
ENOG410ZKHN LUCA
GeneTreeiENSGT00760000119071
HOGENOMiHOG000113032
HOVERGENiHBG052098
InParanoidiQ13478
KOiK05173
OMAiFTRGMII
OrthoDBiEOG091G0GXW
PhylomeDBiQ13478
TreeFamiTF325519

Family and domain databases

Gene3Di2.60.40.10, 3 hits
3.40.50.10140, 1 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR015621 IL-1_rcpt_fam
IPR004074 IL-1_rcpt_I/II-typ
IPR000157 TIR_dom
IPR035897 Toll_tir_struct_dom_sf
PANTHERiPTHR11890 PTHR11890, 1 hit
PfamiView protein in Pfam
PF01582 TIR, 1 hit
PRINTSiPR01536 INTRLKN1R12F
SMARTiView protein in SMART
SM00409 IG, 3 hits
SM00255 TIR, 1 hit
SUPFAMiSSF48726 SSF48726, 2 hits
SSF52200 SSF52200, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit
PS50104 TIR, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q13478-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNCRELPLTL WVLISVSTAE SCTSRPHITV VEGEPFYLKH CSCSLAHEIE
60 70 80 90 100
TTTKSWYKSS GSQEHVELNP RSSSRIALHD CVLEFWPVEL NDTGSYFFQM
110 120 130 140 150
KNYTQKWKLN VIRRNKHSCF TERQVTSKIV EVKKFFQITC ENSYYQTLVN
160 170 180 190 200
STSLYKNCKK LLLENNKNPT IKKNAEFEDQ GYYSCVHFLH HNGKLFNITK
210 220 230 240 250
TFNITIVEDR SNIVPVLLGP KLNHVAVELG KNVRLNCSAL LNEEDVIYWM
260 270 280 290 300
FGEENGSDPN IHEEKEMRIM TPEGKWHASK VLRIENIGES NLNVLYNCTV
310 320 330 340 350
ASTGGTDTKS FILVRKADMA DIPGHVFTRG MIIAVLILVA VVCLVTVCVI
360 370 380 390 400
YRVDLVLFYR HLTRRDETLT DGKTYDAFVS YLKECRPENG EEHTFAVEIL
410 420 430 440 450
PRVLEKHFGY KLCIFERDVV PGGAVVDEIH SLIEKSRRLI IVLSKSYMSN
460 470 480 490 500
EVRYELESGL HEALVERKIK IILIEFTPVT DFTFLPQSLK LLKSHRVLKW
510 520 530 540
KADKSLSYNS RFWKNLLYLM PAKTVKPGRD EPEVLPVLSE S
Length:541
Mass (Da):62,304
Last modified:November 1, 1996 - v1
Checksum:i7173DB9C7EA71D32
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q86YL8Q86YL8_HUMAN
Interleukin-18 receptor 1
IL18R1
170Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_053379210R → H. Corresponds to variant dbSNP:rs11465635Ensembl.1
Natural variantiVAR_053380232N → K. Corresponds to variant dbSNP:rs11465644Ensembl.1
Natural variantiVAR_053381310S → N. Corresponds to variant dbSNP:rs11465648Ensembl.1
Natural variantiVAR_014955317Missing 1 Publication1
Natural variantiVAR_053382423G → R. Corresponds to variant dbSNP:rs12619169Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U43672 mRNA Translation: AAC50390.1
AK313967 mRNA Translation: BAG36682.1
AC007248 Genomic DNA Translation: AAY15048.1
BC069575 mRNA Translation: AAH69575.1
BC093975 mRNA Translation: AAH93975.1
BC093977 mRNA Translation: AAH93977.1
CCDSiCCDS2060.1
RefSeqiNP_001269328.1, NM_001282399.1
NP_003846.1, NM_003855.3
UniGeneiHs.469521

Genome annotation databases

EnsembliENST00000233957; ENSP00000233957; ENSG00000115604
ENST00000409599; ENSP00000387211; ENSG00000115604
ENST00000410040; ENSP00000386663; ENSG00000115604
GeneIDi8809
KEGGihsa:8809
UCSCiuc002tbw.6 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U43672 mRNA Translation: AAC50390.1
AK313967 mRNA Translation: BAG36682.1
AC007248 Genomic DNA Translation: AAY15048.1
BC069575 mRNA Translation: AAH69575.1
BC093975 mRNA Translation: AAH93975.1
BC093977 mRNA Translation: AAH93977.1
CCDSiCCDS2060.1
RefSeqiNP_001269328.1, NM_001282399.1
NP_003846.1, NM_003855.3
UniGeneiHs.469521

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3WO3X-ray3.10B/D/F/H/J/L20-329[»]
3WO4X-ray3.10B20-329[»]
4R6UX-ray2.80A/C19-329[»]
ProteinModelPortaliQ13478
SMRiQ13478
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114337, 2 interactors
IntActiQ13478, 1 interactor
MINTiQ13478
STRINGi9606.ENSP00000233957

PTM databases

iPTMnetiQ13478
PhosphoSitePlusiQ13478

Proteomic databases

EPDiQ13478
MaxQBiQ13478
PaxDbiQ13478
PeptideAtlasiQ13478
PRIDEiQ13478
ProteomicsDBi59476

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000233957; ENSP00000233957; ENSG00000115604
ENST00000409599; ENSP00000387211; ENSG00000115604
ENST00000410040; ENSP00000386663; ENSG00000115604
GeneIDi8809
KEGGihsa:8809
UCSCiuc002tbw.6 human

Organism-specific databases

CTDi8809
DisGeNETi8809
EuPathDBiHostDB:ENSG00000115604.10
GeneCardsiIL18R1
HGNCiHGNC:5988 IL18R1
HPAiHPA007615
MIMi604494 gene
neXtProtiNX_Q13478
OpenTargetsiENSG00000115604
PharmGKBiPA29804
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IH1W Eukaryota
ENOG410ZKHN LUCA
GeneTreeiENSGT00760000119071
HOGENOMiHOG000113032
HOVERGENiHBG052098
InParanoidiQ13478
KOiK05173
OMAiFTRGMII
OrthoDBiEOG091G0GXW
PhylomeDBiQ13478
TreeFamiTF325519

Enzyme and pathway databases

ReactomeiR-HSA-9008059 Interleukin-37 signaling
R-HSA-9012546 Interleukin-18 signaling
SIGNORiQ13478

Miscellaneous databases

GeneWikiiIL18R1
GenomeRNAii8809
PROiPR:Q13478
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000115604 Expressed in 131 organ(s), highest expression level in right lung
CleanExiHS_IL18R1
ExpressionAtlasiQ13478 baseline and differential
GenevisibleiQ13478 HS

Family and domain databases

Gene3Di2.60.40.10, 3 hits
3.40.50.10140, 1 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR015621 IL-1_rcpt_fam
IPR004074 IL-1_rcpt_I/II-typ
IPR000157 TIR_dom
IPR035897 Toll_tir_struct_dom_sf
PANTHERiPTHR11890 PTHR11890, 1 hit
PfamiView protein in Pfam
PF01582 TIR, 1 hit
PRINTSiPR01536 INTRLKN1R12F
SMARTiView protein in SMART
SM00409 IG, 3 hits
SM00255 TIR, 1 hit
SUPFAMiSSF48726 SSF48726, 2 hits
SSF52200 SSF52200, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit
PS50104 TIR, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiIL18R_HUMAN
AccessioniPrimary (citable) accession number: Q13478
Secondary accession number(s): B2R9Y5, Q52LC9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 6, 2002
Last sequence update: November 1, 1996
Last modified: November 7, 2018
This is version 161 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
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