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Entry version 174 (31 Jul 2019)
Sequence version 1 (01 Nov 1997)
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Protein

DNA topoisomerase 3-alpha

Gene

TOP3A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone. As an essential component of the RMI complex it is involved in chromosome separation and the processing of homologous recombination intermediates to limit DNA crossover formation in cells. Has DNA decatenation activity (PubMed:30057030). It is required for mtDNA decatenation and segregation after completion of replication, in a process that does not require BLM, RMI1 and RMI2 (PubMed:29290614).4 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mg2+1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei362O-(5'-phospho-DNA)-tyrosine intermediateBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri658 – 685C4-typeSequence analysisAdd BLAST28

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding, Isomerase, Topoisomerase
LigandMagnesium, Metal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-5685938 HDR through Single Strand Annealing (SSA)
R-HSA-5685942 HDR through Homologous Recombination (HRR)
R-HSA-5693554 Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)
R-HSA-5693568 Resolution of D-loop Structures through Holliday Junction Intermediates
R-HSA-5693579 Homologous DNA Pairing and Strand Exchange
R-HSA-5693607 Processing of DNA double-strand break ends
R-HSA-5693616 Presynaptic phase of homologous DNA pairing and strand exchange
R-HSA-6804756 Regulation of TP53 Activity through Phosphorylation
R-HSA-69473 G2/M DNA damage checkpoint
R-HSA-912446 Meiotic recombination

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
DNA topoisomerase 3-alpha (EC:5.6.2.1PROSITE-ProRule annotation2 Publications)
Alternative name(s):
DNA topoisomerase III alpha
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TOP3A
Synonyms:TOP3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:11992 TOP3A

Online Mendelian Inheritance in Man (OMIM)

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MIMi
601243 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q13472

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Microcephaly, growth restriction, and increased sister chromatid exchange 2 (MGRISCE2)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal recessive disorder characterized by intrauterine growth restriction, poor postnatal growth with short stature and microcephaly, and increased sister chromatid exchange on cell studies.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_081107176A → V in MGRISCE2. 1 Publication1
Progressive external ophthalmoplegia with mitochondrial DNA deletions, autosomal recessive 5 (PEOB5)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of progressive external ophthalmoplegia, a mitochondrial myopathy characterized by progressive paralysis of the levator palpebrae, orbicularis oculi, and extraocular muscles. PEOB5 features include slowly progressive ptosis, intermittent double vision, cardiac arrhythmias, exercise intolerance, proximal limb and neck muscle weakness, and cerebellar ataxia. Patients skeletal muscle biopsy show numerous COX-deficient ragged-red fibers, increased mtDNA deletions, and extensive variable mtDNA rearrangements.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_081105100M → V in PEOB5; results in decreased DNA decatenation. 1 PublicationCorresponds to variant dbSNP:rs376902371EnsemblClinVar.1
Natural variantiVAR_081106135 – 1001Missing in PEOB5. 1 PublicationAdd BLAST867

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi362Y → F: Decreased DNA decatenation. 1 Publication1

Keywords - Diseasei

Disease mutation, Dwarfism, Primary mitochondrial disease, Progressive external ophthalmoplegia

Organism-specific databases

DisGeNET

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DisGeNETi
7156

MalaCards human disease database

More...
MalaCardsi
TOP3A
MIMi618097 phenotype
618098 phenotype

Open Targets

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OpenTargetsi
ENSG00000177302

Orphanet; a database dedicated to information on rare diseases and orphan drugs

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Orphaneti
508512 Congenital multiple cafe-au-lait macules-increased sister chromatid exchange syndrome

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA36673

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TOP3A

Domain mapping of disease mutations (DMDM)

More...
DMDMi
2501242

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001451901 – 1001DNA topoisomerase 3-alphaAdd BLAST1001

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q13472

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q13472

MaxQB - The MaxQuant DataBase

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MaxQBi
Q13472

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q13472

PeptideAtlas

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PeptideAtlasi
Q13472

PRoteomics IDEntifications database

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PRIDEi
Q13472

ProteomicsDB human proteome resource

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ProteomicsDBi
4437
59469 [Q13472-1]
59470 [Q13472-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q13472

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q13472

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

High expression is found in testis, heart, skeletal muscle and pancreas.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000177302 Expressed in 176 organ(s), highest expression level in lung

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q13472 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q13472 HS

Organism-specific databases

Human Protein Atlas

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HPAi
CAB002449

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Binds ssDNA (PubMed:29290614).

Interacts (via N-terminal region) with BLM; the interaction is direct. Directly interacts with RMI1.

Component of the RMI complex, containing at least TOP3A, RMI1 and RMI2. The RMI complex interacts with BLM.

6 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
RMI1Q9H9A710EBI-621345,EBI-621339

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
113009, 70 interactors

ComplexPortal: manually curated resource of macromolecular complexes

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ComplexPortali
CPX-3301 BTR double Holliday Junction dissolution complex

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
Q13472

Database of interacting proteins

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DIPi
DIP-33323N

Protein interaction database and analysis system

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IntActi
Q13472, 18 interactors

Molecular INTeraction database

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MINTi
Q13472

STRING: functional protein association networks

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STRINGi
9606.ENSP00000442336

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11001
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q13472

Database of comparative protein structure models

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ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini35 – 179ToprimPROSITE-ProRule annotationAdd BLAST145
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati812 – 8391Add BLAST28
Repeati896 – 9232Add BLAST28

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni812 – 9232 X 27 AA approximate repeatsAdd BLAST112

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the type IA topoisomerase family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri658 – 685C4-typeSequence analysisAdd BLAST28

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1956 Eukaryota
COG0550 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000156701

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000184377

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q13472

KEGG Orthology (KO)

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KOi
K03165

Identification of Orthologs from Complete Genome Data

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OMAi
LKFKFKR

Database of Orthologous Groups

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OrthoDBi
373433at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q13472

TreeFam database of animal gene trees

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TreeFami
TF105287

Family and domain databases

Conserved Domains Database

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CDDi
cd00186 TOP1Ac, 1 hit
cd03362 TOPRIM_TopoIA_TopoIII, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.10.290.10, 1 hit
1.10.460.10, 1 hit
2.70.20.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR000380 Topo_IA
IPR003601 Topo_IA_2
IPR023406 Topo_IA_AS
IPR013497 Topo_IA_cen
IPR013824 Topo_IA_cen_sub1
IPR013825 Topo_IA_cen_sub2
IPR013826 Topo_IA_cen_sub3
IPR023405 Topo_IA_core_domain
IPR003602 Topo_IA_DNA-bd_dom
IPR013498 Topo_IA_Znf
IPR006171 TOPRIM_domain
IPR034144 TOPRIM_TopoIII
IPR010666 Znf_GRF

The PANTHER Classification System

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PANTHERi
PTHR11390 PTHR11390, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01131 Topoisom_bac, 1 hit
PF01751 Toprim, 1 hit
PF01396 zf-C4_Topoisom, 1 hit
PF06839 zf-GRF, 2 hits

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR00417 PRTPISMRASEI

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00437 TOP1Ac, 1 hit
SM00436 TOP1Bc, 1 hit
SM00493 TOPRIM, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF56712 SSF56712, 1 hit

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS00396 TOPOISOMERASE_I_PROK, 1 hit
PS50880 TOPRIM, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 8 potential isoforms that are computationally mapped.Show allAlign All

Isoform Long (identifier: Q13472-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MIFPVARYAL RWLRRPEDRA FSRAAMEMAL RGVRKVLCVA EKNDAAKGIA
60 70 80 90 100
DLLSNGRMRR REGLSKFNKI YEFDYHLYGQ NVTMVMTSVS GHLLAHDFQM
110 120 130 140 150
QFRKWQSCNP LVLFEAEIEK YCPENFVDIK KTLERETRQC QALVIWTDCD
160 170 180 190 200
REGENIGFEI IHVCKAVKPN LQVLRARFSE ITPHAVRTAC ENLTEPDQRV
210 220 230 240 250
SDAVDVRQEL DLRIGAAFTR FQTLRLQRIF PEVLAEQLIS YGSCQFPTLG
260 270 280 290 300
FVVERFKAIQ AFVPEIFHRI KVTHDHKDGI VEFNWKRHRL FNHTACLVLY
310 320 330 340 350
QLCVEDPMAT VVEVRSKPKS KWRPQALDTV ELEKLASRKL RINAKETMRI
360 370 380 390 400
AEKLYTQGYI SYPRTETNIF PRDLNLTVLV EQQTPDPRWG AFAQSILERG
410 420 430 440 450
GPTPRNGNKS DQAHPPIHPT KYTNNLQGDE QRLYEFIVRH FLACCSQDAQ
460 470 480 490 500
GQETTVEIDI AQERFVAHGL MILARNYLDV YPYDHWSDKI LPVYEQGSHF
510 520 530 540 550
QPSTVEMVDG ETSPPKLLTE ADLIALMEKH GIGTDATHAE HIETIKARMY
560 570 580 590 600
VGLTPDKRFL PGHLGMGLVE GYDSMGYEMS KPDLRAELEA DLKLICDGKK
610 620 630 640 650
DKFVVLRQQV QKYKQVFIEA VAKAKKLDEA LAQYFGNGTE LAQQEDIYPA
660 670 680 690 700
MPEPIRKCPQ CNKDMVLKTK KNGGFYLSCM GFPECRSAVW LPDSVLEASR
710 720 730 740 750
DSSVCPVCQP HPVYRLKLKF KRGSLPPTMP LEFVCCIGGC DDTLREILDL
760 770 780 790 800
RFSGGPPRAS QPSGRLQANQ SLNRMDNSQH PQPADSRQTG SSKALAQTLP
810 820 830 840 850
PPTAAGESNS VTCNCGQEAV LLTVRKEGPN RGRQFFKCNG GSCNFFLWAD
860 870 880 890 900
SPNPGAGGPP ALAYRPLGAS LGCPPGPGIH LGGFGNPGDG SGSGTSCLCS
910 920 930 940 950
QPSVTRTVQK DGPNKGRQFH TCAKPREQQC GFFQWVDENT APGTSGAPSW
960 970 980 990 1000
TGDRGRTLES EARSKRPRAS SSDMGSTAKK PRKCSLCHQP GHTRPFCPQN

R
Length:1,001
Mass (Da):112,372
Last modified:November 1, 1997 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i06558C749569E0C2
GO
Isoform Short (identifier: Q13472-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-25: Missing.

Show »
Length:976
Mass (Da):109,341
Checksum:i4AB9262B5DE7D05B
GO
Isoform 3 (identifier: Q13472-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-105: MIFPVARYAL...HDFQMQFRKW → MNLIIICMAR

Note: No experimental confirmation available.
Show »
Length:906
Mass (Da):101,208
Checksum:i60F389C5FF1A92F9
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
K7ELI7K7ELI7_HUMAN
DNA topoisomerase
TOP3A
133Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EMT6K7EMT6_HUMAN
DNA topoisomerase
TOP3A
163Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3KS96J3KS96_HUMAN
DNA topoisomerase
TOP3A
89Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3QS25J3QS25_HUMAN
DNA topoisomerase
TOP3A
95Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3QR18J3QR18_HUMAN
DNA topoisomerase
TOP3A
139Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EJ41K7EJ41_HUMAN
DNA topoisomerase 3-alpha
TOP3A
52Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EL07K7EL07_HUMAN
DNA topoisomerase 3-alpha
TOP3A
25Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3KRR9J3KRR9_HUMAN
DNA topoisomerase 3-alpha
TOP3A
69Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_081105100M → V in PEOB5; results in decreased DNA decatenation. 1 PublicationCorresponds to variant dbSNP:rs376902371EnsemblClinVar.1
Natural variantiVAR_081106135 – 1001Missing in PEOB5. 1 PublicationAdd BLAST867
Natural variantiVAR_081107176A → V in MGRISCE2. 1 Publication1
Natural variantiVAR_052588459D → N. Corresponds to variant dbSNP:rs28671051Ensembl.1
Natural variantiVAR_007529596C → Y. 1
Natural variantiVAR_052589742D → N. Corresponds to variant dbSNP:rs9909732Ensembl.1
Natural variantiVAR_052590773N → D. Corresponds to variant dbSNP:rs9911283Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0541891 – 105MIFPV…QFRKW → MNLIIICMAR in isoform 3. 1 PublicationAdd BLAST105
Alternative sequenceiVSP_0065241 – 25Missing in isoform Short. 1 PublicationAdd BLAST25

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U43431 mRNA Translation: AAB03694.1
U43431 mRNA Translation: AAB03695.1
HQ205026 Genomic DNA Translation: ADP90454.1
HQ205027 Genomic DNA Translation: ADP90455.1
HQ205028 Genomic DNA Translation: ADP90456.1
HQ205029 Genomic DNA Translation: ADP90457.1
HQ205030 Genomic DNA Translation: ADP90458.1
HQ205031 Genomic DNA Translation: ADP90459.1
HQ205032 Genomic DNA Translation: ADP90460.1
HQ205033 Genomic DNA Translation: ADP90461.1
HQ205034 Genomic DNA Translation: ADP90462.1
HQ205035 Genomic DNA Translation: ADP90463.1
HQ205036 Genomic DNA Translation: ADP90464.1
HQ205037 Genomic DNA Translation: ADP90465.1
HQ205038 Genomic DNA Translation: ADP90466.1
HQ205039 Genomic DNA Translation: ADP90467.1
HQ205040 Genomic DNA Translation: ADP90468.1
HQ205041 Genomic DNA Translation: ADP90469.1
HQ205042 Genomic DNA Translation: ADP90470.1
HQ205043 Genomic DNA Translation: ADP90471.1
HQ205044 Genomic DNA Translation: ADP90472.1
HQ205045 Genomic DNA Translation: ADP90473.1
HQ205046 Genomic DNA Translation: ADP90474.1
HQ205047 Genomic DNA Translation: ADP90475.1
HQ205048 Genomic DNA Translation: ADP90476.1
HQ205049 Genomic DNA Translation: ADP90477.1
HQ205050 Genomic DNA Translation: ADP90478.1
HQ205051 Genomic DNA Translation: ADP90479.1
HQ205052 Genomic DNA Translation: ADP90480.1
HQ205053 Genomic DNA Translation: ADP90481.1
HQ205054 Genomic DNA Translation: ADP90482.1
HQ205055 Genomic DNA Translation: ADP90483.1
HQ205056 Genomic DNA Translation: ADP90484.1
HQ205057 Genomic DNA Translation: ADP90485.1
HQ205058 Genomic DNA Translation: ADP90486.1
HQ205059 Genomic DNA Translation: ADP90487.1
HQ205060 Genomic DNA Translation: ADP90488.1
HQ205061 Genomic DNA Translation: ADP90489.1
HQ205062 Genomic DNA Translation: ADP90490.1
HQ205063 Genomic DNA Translation: ADP90491.1
HQ205064 Genomic DNA Translation: ADP90492.1
HQ205065 Genomic DNA Translation: ADP90493.1
AK292926 mRNA Translation: BAF85615.1
AK296437 mRNA Translation: BAG59092.1
AC127537 Genomic DNA No translation available.
CH471196 Genomic DNA Translation: EAW55646.1
CH471196 Genomic DNA Translation: EAW55648.1
CH471196 Genomic DNA Translation: EAW55649.1
BC051748 mRNA Translation: AAH51748.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS11194.1 [Q13472-1]

NCBI Reference Sequences

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RefSeqi
NP_001307688.1, NM_001320759.1 [Q13472-3]
NP_004609.1, NM_004618.4 [Q13472-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000321105; ENSP00000321636; ENSG00000177302 [Q13472-1]
ENST00000542570; ENSP00000442336; ENSG00000177302 [Q13472-1]
ENST00000580095; ENSP00000462790; ENSG00000177302 [Q13472-2]
ENST00000638894; ENSP00000492229; ENSG00000284238 [Q13472-1]
ENST00000639065; ENSP00000491260; ENSG00000284238 [Q13472-2]
ENST00000640743; ENSP00000491689; ENSG00000284238 [Q13472-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
7156

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:7156

UCSC genome browser

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UCSCi
uc002gsx.1 human [Q13472-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U43431 mRNA Translation: AAB03694.1
U43431 mRNA Translation: AAB03695.1
HQ205026 Genomic DNA Translation: ADP90454.1
HQ205027 Genomic DNA Translation: ADP90455.1
HQ205028 Genomic DNA Translation: ADP90456.1
HQ205029 Genomic DNA Translation: ADP90457.1
HQ205030 Genomic DNA Translation: ADP90458.1
HQ205031 Genomic DNA Translation: ADP90459.1
HQ205032 Genomic DNA Translation: ADP90460.1
HQ205033 Genomic DNA Translation: ADP90461.1
HQ205034 Genomic DNA Translation: ADP90462.1
HQ205035 Genomic DNA Translation: ADP90463.1
HQ205036 Genomic DNA Translation: ADP90464.1
HQ205037 Genomic DNA Translation: ADP90465.1
HQ205038 Genomic DNA Translation: ADP90466.1
HQ205039 Genomic DNA Translation: ADP90467.1
HQ205040 Genomic DNA Translation: ADP90468.1
HQ205041 Genomic DNA Translation: ADP90469.1
HQ205042 Genomic DNA Translation: ADP90470.1
HQ205043 Genomic DNA Translation: ADP90471.1
HQ205044 Genomic DNA Translation: ADP90472.1
HQ205045 Genomic DNA Translation: ADP90473.1
HQ205046 Genomic DNA Translation: ADP90474.1
HQ205047 Genomic DNA Translation: ADP90475.1
HQ205048 Genomic DNA Translation: ADP90476.1
HQ205049 Genomic DNA Translation: ADP90477.1
HQ205050 Genomic DNA Translation: ADP90478.1
HQ205051 Genomic DNA Translation: ADP90479.1
HQ205052 Genomic DNA Translation: ADP90480.1
HQ205053 Genomic DNA Translation: ADP90481.1
HQ205054 Genomic DNA Translation: ADP90482.1
HQ205055 Genomic DNA Translation: ADP90483.1
HQ205056 Genomic DNA Translation: ADP90484.1
HQ205057 Genomic DNA Translation: ADP90485.1
HQ205058 Genomic DNA Translation: ADP90486.1
HQ205059 Genomic DNA Translation: ADP90487.1
HQ205060 Genomic DNA Translation: ADP90488.1
HQ205061 Genomic DNA Translation: ADP90489.1
HQ205062 Genomic DNA Translation: ADP90490.1
HQ205063 Genomic DNA Translation: ADP90491.1
HQ205064 Genomic DNA Translation: ADP90492.1
HQ205065 Genomic DNA Translation: ADP90493.1
AK292926 mRNA Translation: BAF85615.1
AK296437 mRNA Translation: BAG59092.1
AC127537 Genomic DNA No translation available.
CH471196 Genomic DNA Translation: EAW55646.1
CH471196 Genomic DNA Translation: EAW55648.1
CH471196 Genomic DNA Translation: EAW55649.1
BC051748 mRNA Translation: AAH51748.1
CCDSiCCDS11194.1 [Q13472-1]
RefSeqiNP_001307688.1, NM_001320759.1 [Q13472-3]
NP_004609.1, NM_004618.4 [Q13472-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4CGYX-ray2.85A2-753[»]
4CHTX-ray3.25A2-753[»]
SMRiQ13472
ModBaseiSearch...

Protein-protein interaction databases

BioGridi113009, 70 interactors
ComplexPortaliCPX-3301 BTR double Holliday Junction dissolution complex
CORUMiQ13472
DIPiDIP-33323N
IntActiQ13472, 18 interactors
MINTiQ13472
STRINGi9606.ENSP00000442336

PTM databases

iPTMnetiQ13472
PhosphoSitePlusiQ13472

Polymorphism and mutation databases

BioMutaiTOP3A
DMDMi2501242

Proteomic databases

EPDiQ13472
jPOSTiQ13472
MaxQBiQ13472
PaxDbiQ13472
PeptideAtlasiQ13472
PRIDEiQ13472
ProteomicsDBi4437
59469 [Q13472-1]
59470 [Q13472-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000321105; ENSP00000321636; ENSG00000177302 [Q13472-1]
ENST00000542570; ENSP00000442336; ENSG00000177302 [Q13472-1]
ENST00000580095; ENSP00000462790; ENSG00000177302 [Q13472-2]
ENST00000638894; ENSP00000492229; ENSG00000284238 [Q13472-1]
ENST00000639065; ENSP00000491260; ENSG00000284238 [Q13472-2]
ENST00000640743; ENSP00000491689; ENSG00000284238 [Q13472-1]
GeneIDi7156
KEGGihsa:7156
UCSCiuc002gsx.1 human [Q13472-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
7156
DisGeNETi7156

GeneCards: human genes, protein and diseases

More...
GeneCardsi
TOP3A
HGNCiHGNC:11992 TOP3A
HPAiCAB002449
MalaCardsiTOP3A
MIMi601243 gene
618097 phenotype
618098 phenotype
neXtProtiNX_Q13472
OpenTargetsiENSG00000177302
Orphaneti508512 Congenital multiple cafe-au-lait macules-increased sister chromatid exchange syndrome
PharmGKBiPA36673

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1956 Eukaryota
COG0550 LUCA
GeneTreeiENSGT00940000156701
HOGENOMiHOG000184377
InParanoidiQ13472
KOiK03165
OMAiLKFKFKR
OrthoDBi373433at2759
PhylomeDBiQ13472
TreeFamiTF105287

Enzyme and pathway databases

ReactomeiR-HSA-5685938 HDR through Single Strand Annealing (SSA)
R-HSA-5685942 HDR through Homologous Recombination (HRR)
R-HSA-5693554 Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)
R-HSA-5693568 Resolution of D-loop Structures through Holliday Junction Intermediates
R-HSA-5693579 Homologous DNA Pairing and Strand Exchange
R-HSA-5693607 Processing of DNA double-strand break ends
R-HSA-5693616 Presynaptic phase of homologous DNA pairing and strand exchange
R-HSA-6804756 Regulation of TP53 Activity through Phosphorylation
R-HSA-69473 G2/M DNA damage checkpoint
R-HSA-912446 Meiotic recombination

Miscellaneous databases

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
TOP3A

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
7156

Protein Ontology

More...
PROi
PR:Q13472

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000177302 Expressed in 176 organ(s), highest expression level in lung
ExpressionAtlasiQ13472 baseline and differential
GenevisibleiQ13472 HS

Family and domain databases

CDDicd00186 TOP1Ac, 1 hit
cd03362 TOPRIM_TopoIA_TopoIII, 1 hit
Gene3Di1.10.290.10, 1 hit
1.10.460.10, 1 hit
2.70.20.10, 1 hit
InterProiView protein in InterPro
IPR000380 Topo_IA
IPR003601 Topo_IA_2
IPR023406 Topo_IA_AS
IPR013497 Topo_IA_cen
IPR013824 Topo_IA_cen_sub1
IPR013825 Topo_IA_cen_sub2
IPR013826 Topo_IA_cen_sub3
IPR023405 Topo_IA_core_domain
IPR003602 Topo_IA_DNA-bd_dom
IPR013498 Topo_IA_Znf
IPR006171 TOPRIM_domain
IPR034144 TOPRIM_TopoIII
IPR010666 Znf_GRF
PANTHERiPTHR11390 PTHR11390, 1 hit
PfamiView protein in Pfam
PF01131 Topoisom_bac, 1 hit
PF01751 Toprim, 1 hit
PF01396 zf-C4_Topoisom, 1 hit
PF06839 zf-GRF, 2 hits
PRINTSiPR00417 PRTPISMRASEI
SMARTiView protein in SMART
SM00437 TOP1Ac, 1 hit
SM00436 TOP1Bc, 1 hit
SM00493 TOPRIM, 1 hit
SUPFAMiSSF56712 SSF56712, 1 hit
PROSITEiView protein in PROSITE
PS00396 TOPOISOMERASE_I_PROK, 1 hit
PS50880 TOPRIM, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTOP3A_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q13472
Secondary accession number(s): A8KA61
, B4DK80, D3DXC7, Q13473
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: July 31, 2019
This is version 174 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
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