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Protein

DNA topoisomerase 3-alpha

Gene

TOP3A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone. Essential component of the RMI complex, a complex that plays an important role in the processing of homologous recombination intermediates to limit DNA crossover formation in cells. Has DNA decatenation activity.2 Publications

Catalytic activityi

ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.PROSITE-ProRule annotation2 Publications

Cofactori

Mg2+1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei362O-(5'-phospho-DNA)-tyrosine intermediateBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri658 – 685C4-typeSequence analysisAdd BLAST28

GO - Molecular functioni

  • DNA binding Source: ProtInc
  • DNA topoisomerase activity Source: GO_Central
  • DNA topoisomerase type I activity Source: UniProtKB
  • zinc ion binding Source: InterPro

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, Isomerase, Topoisomerase
LigandMagnesium, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-5685938 HDR through Single Strand Annealing (SSA)
R-HSA-5685942 HDR through Homologous Recombination (HRR)
R-HSA-5693554 Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)
R-HSA-5693568 Resolution of D-loop Structures through Holliday Junction Intermediates
R-HSA-5693579 Homologous DNA Pairing and Strand Exchange
R-HSA-5693607 Processing of DNA double-strand break ends
R-HSA-5693616 Presynaptic phase of homologous DNA pairing and strand exchange
R-HSA-6804756 Regulation of TP53 Activity through Phosphorylation
R-HSA-69473 G2/M DNA damage checkpoint
R-HSA-912446 Meiotic recombination

Names & Taxonomyi

Protein namesi
Recommended name:
DNA topoisomerase 3-alpha (EC:5.99.1.2)
Alternative name(s):
DNA topoisomerase III alpha
Gene namesi
Name:TOP3A
Synonyms:TOP3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000177302.14
HGNCiHGNC:11992 TOP3A
MIMi601243 gene
neXtProtiNX_Q13472

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi7156
MalaCardsiTOP3A
OpenTargetsiENSG00000177302
PharmGKBiPA36673

Polymorphism and mutation databases

BioMutaiTOP3A
DMDMi2501242

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001451901 – 1001DNA topoisomerase 3-alphaAdd BLAST1001

Proteomic databases

EPDiQ13472
MaxQBiQ13472
PaxDbiQ13472
PeptideAtlasiQ13472
PRIDEiQ13472
ProteomicsDBi59469
59470 [Q13472-2]

PTM databases

iPTMnetiQ13472
PhosphoSitePlusiQ13472

Expressioni

Tissue specificityi

High expression is found in testis, heart, skeletal muscle and pancreas.

Gene expression databases

BgeeiENSG00000177302 Expressed in 176 organ(s), highest expression level in lung
CleanExiHS_TOP3A
ExpressionAtlasiQ13472 baseline and differential
GenevisibleiQ13472 HS

Organism-specific databases

HPAiCAB002449

Interactioni

Subunit structurei

Interacts (via N-terminal region) with BLM; the interaction is direct. Directly interacts with RMI1. Component of the RMI complex, containing at least TOP3A, RMI1 and RMI2. The RMI complex interacts with BLM.5 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
RMI1Q9H9A710EBI-621345,EBI-621339

Protein-protein interaction databases

BioGridi113009, 66 interactors
ComplexPortaliCPX-3301 BTR double Holliday Junction dissolution complex
CORUMiQ13472
DIPiDIP-33323N
IntActiQ13472, 17 interactors
MINTiQ13472
STRINGi9606.ENSP00000321636

Structurei

Secondary structure

11001
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ13472
SMRiQ13472
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini35 – 179ToprimPROSITE-ProRule annotationAdd BLAST145
Repeati812 – 8391Add BLAST28
Repeati896 – 9232Add BLAST28

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni812 – 9232 X 27 AA approximate repeatsAdd BLAST112

Sequence similaritiesi

Belongs to the type IA topoisomerase family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri658 – 685C4-typeSequence analysisAdd BLAST28

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1956 Eukaryota
COG0550 LUCA
GeneTreeiENSGT00530000063430
HOGENOMiHOG000184377
HOVERGENiHBG056668
InParanoidiQ13472
KOiK03165
OMAiLKFKFKR
OrthoDBiEOG091G03BD
PhylomeDBiQ13472
TreeFamiTF105287

Family and domain databases

CDDicd00186 TOP1Ac, 1 hit
cd03362 TOPRIM_TopoIA_TopoIII, 1 hit
Gene3Di1.10.290.10, 1 hit
1.10.460.10, 1 hit
2.70.20.10, 1 hit
InterProiView protein in InterPro
IPR000380 Topo_IA
IPR003601 Topo_IA_2
IPR023406 Topo_IA_AS
IPR013497 Topo_IA_cen
IPR013824 Topo_IA_cen_sub1
IPR013825 Topo_IA_cen_sub2
IPR013826 Topo_IA_cen_sub3
IPR023405 Topo_IA_core_domain
IPR003602 Topo_IA_DNA-bd_dom
IPR013498 Topo_IA_Znf
IPR006171 TOPRIM_domain
IPR034144 TOPRIM_TopoIII
IPR010666 Znf_GRF
PANTHERiPTHR11390 PTHR11390, 1 hit
PfamiView protein in Pfam
PF01131 Topoisom_bac, 1 hit
PF01751 Toprim, 1 hit
PF01396 zf-C4_Topoisom, 1 hit
PF06839 zf-GRF, 2 hits
PRINTSiPR00417 PRTPISMRASEI
SMARTiView protein in SMART
SM00437 TOP1Ac, 1 hit
SM00436 TOP1Bc, 1 hit
SM00493 TOPRIM, 1 hit
SUPFAMiSSF56712 SSF56712, 1 hit
PROSITEiView protein in PROSITE
PS00396 TOPOISOMERASE_I_PROK, 1 hit
PS50880 TOPRIM, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 8 potential isoforms that are computationally mapped.Show allAlign All

Isoform Long (identifier: Q13472-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MIFPVARYAL RWLRRPEDRA FSRAAMEMAL RGVRKVLCVA EKNDAAKGIA
60 70 80 90 100
DLLSNGRMRR REGLSKFNKI YEFDYHLYGQ NVTMVMTSVS GHLLAHDFQM
110 120 130 140 150
QFRKWQSCNP LVLFEAEIEK YCPENFVDIK KTLERETRQC QALVIWTDCD
160 170 180 190 200
REGENIGFEI IHVCKAVKPN LQVLRARFSE ITPHAVRTAC ENLTEPDQRV
210 220 230 240 250
SDAVDVRQEL DLRIGAAFTR FQTLRLQRIF PEVLAEQLIS YGSCQFPTLG
260 270 280 290 300
FVVERFKAIQ AFVPEIFHRI KVTHDHKDGI VEFNWKRHRL FNHTACLVLY
310 320 330 340 350
QLCVEDPMAT VVEVRSKPKS KWRPQALDTV ELEKLASRKL RINAKETMRI
360 370 380 390 400
AEKLYTQGYI SYPRTETNIF PRDLNLTVLV EQQTPDPRWG AFAQSILERG
410 420 430 440 450
GPTPRNGNKS DQAHPPIHPT KYTNNLQGDE QRLYEFIVRH FLACCSQDAQ
460 470 480 490 500
GQETTVEIDI AQERFVAHGL MILARNYLDV YPYDHWSDKI LPVYEQGSHF
510 520 530 540 550
QPSTVEMVDG ETSPPKLLTE ADLIALMEKH GIGTDATHAE HIETIKARMY
560 570 580 590 600
VGLTPDKRFL PGHLGMGLVE GYDSMGYEMS KPDLRAELEA DLKLICDGKK
610 620 630 640 650
DKFVVLRQQV QKYKQVFIEA VAKAKKLDEA LAQYFGNGTE LAQQEDIYPA
660 670 680 690 700
MPEPIRKCPQ CNKDMVLKTK KNGGFYLSCM GFPECRSAVW LPDSVLEASR
710 720 730 740 750
DSSVCPVCQP HPVYRLKLKF KRGSLPPTMP LEFVCCIGGC DDTLREILDL
760 770 780 790 800
RFSGGPPRAS QPSGRLQANQ SLNRMDNSQH PQPADSRQTG SSKALAQTLP
810 820 830 840 850
PPTAAGESNS VTCNCGQEAV LLTVRKEGPN RGRQFFKCNG GSCNFFLWAD
860 870 880 890 900
SPNPGAGGPP ALAYRPLGAS LGCPPGPGIH LGGFGNPGDG SGSGTSCLCS
910 920 930 940 950
QPSVTRTVQK DGPNKGRQFH TCAKPREQQC GFFQWVDENT APGTSGAPSW
960 970 980 990 1000
TGDRGRTLES EARSKRPRAS SSDMGSTAKK PRKCSLCHQP GHTRPFCPQN

R
Length:1,001
Mass (Da):112,372
Last modified:November 1, 1997 - v1
Checksum:i06558C749569E0C2
GO
Isoform Short (identifier: Q13472-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-25: Missing.

Show »
Length:976
Mass (Da):109,341
Checksum:i4AB9262B5DE7D05B
GO
Isoform 3 (identifier: Q13472-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-105: MIFPVARYAL...HDFQMQFRKW → MNLIIICMAR

Note: No experimental confirmation available.
Show »
Length:906
Mass (Da):101,208
Checksum:i60F389C5FF1A92F9
GO

Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
K7ELI7K7ELI7_HUMAN
DNA topoisomerase
TOP3A
133Annotation score:
K7EMT6K7EMT6_HUMAN
DNA topoisomerase
TOP3A
163Annotation score:
J3QS25J3QS25_HUMAN
DNA topoisomerase
TOP3A
95Annotation score:
J3QR18J3QR18_HUMAN
DNA topoisomerase
TOP3A
139Annotation score:
J3KS96J3KS96_HUMAN
DNA topoisomerase
TOP3A
89Annotation score:
K7EJ41K7EJ41_HUMAN
DNA topoisomerase 3-alpha
TOP3A
52Annotation score:
K7EL07K7EL07_HUMAN
DNA topoisomerase 3-alpha
TOP3A
25Annotation score:
J3KRR9J3KRR9_HUMAN
DNA topoisomerase 3-alpha
TOP3A
69Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_052588459D → N. Corresponds to variant dbSNP:rs28671051Ensembl.1
Natural variantiVAR_007529596C → Y. 1
Natural variantiVAR_052589742D → N. Corresponds to variant dbSNP:rs9909732Ensembl.1
Natural variantiVAR_052590773N → D. Corresponds to variant dbSNP:rs9911283Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0541891 – 105MIFPV…QFRKW → MNLIIICMAR in isoform 3. 1 PublicationAdd BLAST105
Alternative sequenceiVSP_0065241 – 25Missing in isoform Short. 1 PublicationAdd BLAST25

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U43431 mRNA Translation: AAB03694.1
U43431 mRNA Translation: AAB03695.1
HQ205026 Genomic DNA Translation: ADP90454.1
HQ205027 Genomic DNA Translation: ADP90455.1
HQ205028 Genomic DNA Translation: ADP90456.1
HQ205029 Genomic DNA Translation: ADP90457.1
HQ205030 Genomic DNA Translation: ADP90458.1
HQ205031 Genomic DNA Translation: ADP90459.1
HQ205032 Genomic DNA Translation: ADP90460.1
HQ205033 Genomic DNA Translation: ADP90461.1
HQ205034 Genomic DNA Translation: ADP90462.1
HQ205035 Genomic DNA Translation: ADP90463.1
HQ205036 Genomic DNA Translation: ADP90464.1
HQ205037 Genomic DNA Translation: ADP90465.1
HQ205038 Genomic DNA Translation: ADP90466.1
HQ205039 Genomic DNA Translation: ADP90467.1
HQ205040 Genomic DNA Translation: ADP90468.1
HQ205041 Genomic DNA Translation: ADP90469.1
HQ205042 Genomic DNA Translation: ADP90470.1
HQ205043 Genomic DNA Translation: ADP90471.1
HQ205044 Genomic DNA Translation: ADP90472.1
HQ205045 Genomic DNA Translation: ADP90473.1
HQ205046 Genomic DNA Translation: ADP90474.1
HQ205047 Genomic DNA Translation: ADP90475.1
HQ205048 Genomic DNA Translation: ADP90476.1
HQ205049 Genomic DNA Translation: ADP90477.1
HQ205050 Genomic DNA Translation: ADP90478.1
HQ205051 Genomic DNA Translation: ADP90479.1
HQ205052 Genomic DNA Translation: ADP90480.1
HQ205053 Genomic DNA Translation: ADP90481.1
HQ205054 Genomic DNA Translation: ADP90482.1
HQ205055 Genomic DNA Translation: ADP90483.1
HQ205056 Genomic DNA Translation: ADP90484.1
HQ205057 Genomic DNA Translation: ADP90485.1
HQ205058 Genomic DNA Translation: ADP90486.1
HQ205059 Genomic DNA Translation: ADP90487.1
HQ205060 Genomic DNA Translation: ADP90488.1
HQ205061 Genomic DNA Translation: ADP90489.1
HQ205062 Genomic DNA Translation: ADP90490.1
HQ205063 Genomic DNA Translation: ADP90491.1
HQ205064 Genomic DNA Translation: ADP90492.1
HQ205065 Genomic DNA Translation: ADP90493.1
AK292926 mRNA Translation: BAF85615.1
AK296437 mRNA Translation: BAG59092.1
AC127537 Genomic DNA No translation available.
CH471196 Genomic DNA Translation: EAW55646.1
CH471196 Genomic DNA Translation: EAW55648.1
CH471196 Genomic DNA Translation: EAW55649.1
BC051748 mRNA Translation: AAH51748.1
CCDSiCCDS11194.1 [Q13472-1]
RefSeqiNP_001307688.1, NM_001320759.1 [Q13472-3]
NP_004609.1, NM_004618.4 [Q13472-1]
UniGeneiHs.592115
Hs.713037

Genome annotation databases

EnsembliENST00000321105; ENSP00000321636; ENSG00000177302 [Q13472-1]
ENST00000542570; ENSP00000442336; ENSG00000177302 [Q13472-1]
ENST00000580095; ENSP00000462790; ENSG00000177302 [Q13472-2]
ENST00000638894; ENSP00000492229; ENSG00000284238 [Q13472-1]
ENST00000639065; ENSP00000491260; ENSG00000284238 [Q13472-2]
ENST00000640743; ENSP00000491689; ENSG00000284238 [Q13472-1]
GeneIDi7156
KEGGihsa:7156
UCSCiuc002gsx.1 human [Q13472-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U43431 mRNA Translation: AAB03694.1
U43431 mRNA Translation: AAB03695.1
HQ205026 Genomic DNA Translation: ADP90454.1
HQ205027 Genomic DNA Translation: ADP90455.1
HQ205028 Genomic DNA Translation: ADP90456.1
HQ205029 Genomic DNA Translation: ADP90457.1
HQ205030 Genomic DNA Translation: ADP90458.1
HQ205031 Genomic DNA Translation: ADP90459.1
HQ205032 Genomic DNA Translation: ADP90460.1
HQ205033 Genomic DNA Translation: ADP90461.1
HQ205034 Genomic DNA Translation: ADP90462.1
HQ205035 Genomic DNA Translation: ADP90463.1
HQ205036 Genomic DNA Translation: ADP90464.1
HQ205037 Genomic DNA Translation: ADP90465.1
HQ205038 Genomic DNA Translation: ADP90466.1
HQ205039 Genomic DNA Translation: ADP90467.1
HQ205040 Genomic DNA Translation: ADP90468.1
HQ205041 Genomic DNA Translation: ADP90469.1
HQ205042 Genomic DNA Translation: ADP90470.1
HQ205043 Genomic DNA Translation: ADP90471.1
HQ205044 Genomic DNA Translation: ADP90472.1
HQ205045 Genomic DNA Translation: ADP90473.1
HQ205046 Genomic DNA Translation: ADP90474.1
HQ205047 Genomic DNA Translation: ADP90475.1
HQ205048 Genomic DNA Translation: ADP90476.1
HQ205049 Genomic DNA Translation: ADP90477.1
HQ205050 Genomic DNA Translation: ADP90478.1
HQ205051 Genomic DNA Translation: ADP90479.1
HQ205052 Genomic DNA Translation: ADP90480.1
HQ205053 Genomic DNA Translation: ADP90481.1
HQ205054 Genomic DNA Translation: ADP90482.1
HQ205055 Genomic DNA Translation: ADP90483.1
HQ205056 Genomic DNA Translation: ADP90484.1
HQ205057 Genomic DNA Translation: ADP90485.1
HQ205058 Genomic DNA Translation: ADP90486.1
HQ205059 Genomic DNA Translation: ADP90487.1
HQ205060 Genomic DNA Translation: ADP90488.1
HQ205061 Genomic DNA Translation: ADP90489.1
HQ205062 Genomic DNA Translation: ADP90490.1
HQ205063 Genomic DNA Translation: ADP90491.1
HQ205064 Genomic DNA Translation: ADP90492.1
HQ205065 Genomic DNA Translation: ADP90493.1
AK292926 mRNA Translation: BAF85615.1
AK296437 mRNA Translation: BAG59092.1
AC127537 Genomic DNA No translation available.
CH471196 Genomic DNA Translation: EAW55646.1
CH471196 Genomic DNA Translation: EAW55648.1
CH471196 Genomic DNA Translation: EAW55649.1
BC051748 mRNA Translation: AAH51748.1
CCDSiCCDS11194.1 [Q13472-1]
RefSeqiNP_001307688.1, NM_001320759.1 [Q13472-3]
NP_004609.1, NM_004618.4 [Q13472-1]
UniGeneiHs.592115
Hs.713037

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4CGYX-ray2.85A2-753[»]
4CHTX-ray3.25A2-753[»]
ProteinModelPortaliQ13472
SMRiQ13472
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113009, 66 interactors
ComplexPortaliCPX-3301 BTR double Holliday Junction dissolution complex
CORUMiQ13472
DIPiDIP-33323N
IntActiQ13472, 17 interactors
MINTiQ13472
STRINGi9606.ENSP00000321636

PTM databases

iPTMnetiQ13472
PhosphoSitePlusiQ13472

Polymorphism and mutation databases

BioMutaiTOP3A
DMDMi2501242

Proteomic databases

EPDiQ13472
MaxQBiQ13472
PaxDbiQ13472
PeptideAtlasiQ13472
PRIDEiQ13472
ProteomicsDBi59469
59470 [Q13472-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000321105; ENSP00000321636; ENSG00000177302 [Q13472-1]
ENST00000542570; ENSP00000442336; ENSG00000177302 [Q13472-1]
ENST00000580095; ENSP00000462790; ENSG00000177302 [Q13472-2]
ENST00000638894; ENSP00000492229; ENSG00000284238 [Q13472-1]
ENST00000639065; ENSP00000491260; ENSG00000284238 [Q13472-2]
ENST00000640743; ENSP00000491689; ENSG00000284238 [Q13472-1]
GeneIDi7156
KEGGihsa:7156
UCSCiuc002gsx.1 human [Q13472-1]

Organism-specific databases

CTDi7156
DisGeNETi7156
EuPathDBiHostDB:ENSG00000177302.14
GeneCardsiTOP3A
HGNCiHGNC:11992 TOP3A
HPAiCAB002449
MalaCardsiTOP3A
MIMi601243 gene
neXtProtiNX_Q13472
OpenTargetsiENSG00000177302
PharmGKBiPA36673
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1956 Eukaryota
COG0550 LUCA
GeneTreeiENSGT00530000063430
HOGENOMiHOG000184377
HOVERGENiHBG056668
InParanoidiQ13472
KOiK03165
OMAiLKFKFKR
OrthoDBiEOG091G03BD
PhylomeDBiQ13472
TreeFamiTF105287

Enzyme and pathway databases

ReactomeiR-HSA-5685938 HDR through Single Strand Annealing (SSA)
R-HSA-5685942 HDR through Homologous Recombination (HRR)
R-HSA-5693554 Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)
R-HSA-5693568 Resolution of D-loop Structures through Holliday Junction Intermediates
R-HSA-5693579 Homologous DNA Pairing and Strand Exchange
R-HSA-5693607 Processing of DNA double-strand break ends
R-HSA-5693616 Presynaptic phase of homologous DNA pairing and strand exchange
R-HSA-6804756 Regulation of TP53 Activity through Phosphorylation
R-HSA-69473 G2/M DNA damage checkpoint
R-HSA-912446 Meiotic recombination

Miscellaneous databases

GeneWikiiTOP3A
GenomeRNAii7156
PROiPR:Q13472
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000177302 Expressed in 176 organ(s), highest expression level in lung
CleanExiHS_TOP3A
ExpressionAtlasiQ13472 baseline and differential
GenevisibleiQ13472 HS

Family and domain databases

CDDicd00186 TOP1Ac, 1 hit
cd03362 TOPRIM_TopoIA_TopoIII, 1 hit
Gene3Di1.10.290.10, 1 hit
1.10.460.10, 1 hit
2.70.20.10, 1 hit
InterProiView protein in InterPro
IPR000380 Topo_IA
IPR003601 Topo_IA_2
IPR023406 Topo_IA_AS
IPR013497 Topo_IA_cen
IPR013824 Topo_IA_cen_sub1
IPR013825 Topo_IA_cen_sub2
IPR013826 Topo_IA_cen_sub3
IPR023405 Topo_IA_core_domain
IPR003602 Topo_IA_DNA-bd_dom
IPR013498 Topo_IA_Znf
IPR006171 TOPRIM_domain
IPR034144 TOPRIM_TopoIII
IPR010666 Znf_GRF
PANTHERiPTHR11390 PTHR11390, 1 hit
PfamiView protein in Pfam
PF01131 Topoisom_bac, 1 hit
PF01751 Toprim, 1 hit
PF01396 zf-C4_Topoisom, 1 hit
PF06839 zf-GRF, 2 hits
PRINTSiPR00417 PRTPISMRASEI
SMARTiView protein in SMART
SM00437 TOP1Ac, 1 hit
SM00436 TOP1Bc, 1 hit
SM00493 TOPRIM, 1 hit
SUPFAMiSSF56712 SSF56712, 1 hit
PROSITEiView protein in PROSITE
PS00396 TOPOISOMERASE_I_PROK, 1 hit
PS50880 TOPRIM, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTOP3A_HUMAN
AccessioniPrimary (citable) accession number: Q13472
Secondary accession number(s): A8KA61
, B4DK80, D3DXC7, Q13473
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: November 7, 2018
This is version 168 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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