Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 204 (12 Aug 2020)
Sequence version 3 (08 Mar 2011)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

Unconventional myosin-IXb

Gene

MYO9B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Binds actin with high affinity both in the absence and presence of ATP and its mechanochemical activity is inhibited by calcium ions (PubMed:9490638). Also acts as a GTPase activator for RHOA (PubMed:9490638, PubMed:26529257). Plays a role in the regulation of cell migration via its role as RHOA GTPase activator. This is regulated by its interaction with the SLIT2 receptor ROBO1; interaction with ROBO1 impairs interaction with RHOA and subsequent activation of RHOA GTPase activity, and thereby leads to increased levels of active, GTP-bound RHOA (PubMed:26529257).2 Publications

Caution

Represents an unconventional myosin. This protein should not be confused with the conventional myosin-9 (MYH9).Curated

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi239 – 246ATPSequence analysis8
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri1632 – 1681Phorbol-ester/DAG-typePROSITE-ProRule annotationAdd BLAST50

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin-binding, Calmodulin-binding, GTPase activation, Motor protein, Myosin
LigandATP-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q13459

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-194840, Rho GTPase cycle
R-HSA-2029482, Regulation of actin dynamics for phagocytic cup formation
R-HSA-8985586, SLIT2:ROBO1 increases RHOA activity
R-HSA-9664422, FCGR3A-mediated phagocytosis

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q13459

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Unconventional myosin-IXb
Alternative name(s):
Unconventional myosin-9b
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MYO9B
Synonyms:MYR5
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000099331.13

Human Gene Nomenclature Database

More...
HGNCi
HGNC:7609, MYO9B

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
602129, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q13459

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Celiac disease 4 (CELIAC4)
Disease susceptibility is associated with variations affecting the gene represented in this entry.
Disease descriptionA multifactorial, chronic disorder of the small intestine caused by intolerance to gluten. It is characterized by immune-mediated enteropathy associated with failed intestinal absorption, and malnutrition. In predisposed individuals, the ingestion of gluten-containing food such as wheat and rye induces a flat jejunal mucosa with infiltration of lymphocytes.
Related information in OMIM

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi1739A → E or N: Decreases interaction with RHOA. Strongly decreases stimulation of RHOA GTPase activity. 1 Publication1
Mutagenesisi1741N → E: Decreases interaction with RHOA. Decreases stimulation of RHOA GTPase activity. 1 Publication1
Mutagenesisi1742R → E: Strongly decreases interaction with RHOA. Strongly decreases stimulation of RHOA GTPase activity. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
4650

MalaCards human disease database

More...
MalaCardsi
MYO9B
MIMi609753, phenotype

Open Targets

More...
OpenTargetsi
ENSG00000099331

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q13459, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
MYO9B

Domain mapping of disease mutations (DMDM)

More...
DMDMi
325511388

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001234692 – 2157Unconventional myosin-IXbAdd BLAST2156

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylserineCombined sources1
Modified residuei716PhosphoserineCombined sources1
Modified residuei717PhosphoserineCombined sources1
Modified residuei1045PhosphoserineBy similarity1
Modified residuei1114PhosphoserineCombined sources1
Modified residuei1115PhosphoserineCombined sources1
Modified residuei1122PhosphoserineCombined sources1
Modified residuei1242PhosphoserineCombined sources1
Modified residuei1253PhosphoserineBy similarity1
Modified residuei1261PhosphoserineCombined sources1
Modified residuei1267PhosphoserineCombined sources1
Modified residuei1271PhosphothreonineCombined sources1
Modified residuei1290PhosphoserineCombined sources1
Modified residuei1323PhosphoserineCombined sources1
Modified residuei1331PhosphoserineCombined sources1
Modified residuei1346PhosphothreonineCombined sources1
Modified residuei1354PhosphoserineCombined sources1
Modified residuei1356PhosphoserineCombined sources1
Modified residuei1405PhosphoserineCombined sources1
Modified residuei1926PhosphoserineCombined sources1
Modified residuei1972PhosphoserineCombined sources1
Modified residuei1992PhosphoserineCombined sources1
Modified residuei1999PhosphoserineBy similarity1
Modified residuei2005PhosphothreonineBy similarity1
Modified residuei2050PhosphoserineCombined sources1
Modified residuei2141PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

The CPTAC Assay portal

More...
CPTACi
CPTAC-981
CPTAC-982

Encyclopedia of Proteome Dynamics

More...
EPDi
Q13459

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q13459

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q13459

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q13459

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q13459

PeptideAtlas

More...
PeptideAtlasi
Q13459

PRoteomics IDEntifications database

More...
PRIDEi
Q13459

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
59458 [Q13459-1]
59459 [Q13459-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q13459

MetOSite database of methionine sulfoxide sites

More...
MetOSitei
Q13459

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q13459

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Detected in peripheral blood leukocytes (at protein level) (PubMed:9490638). Expressed predominantly in peripheral blood leukocytes and at lower levels, in thymus, spleen, testis, prostate, ovary, brain, small intestine and lung.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000099331, Expressed in right testis and 219 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q13459, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q13459, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000099331, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts (via IQ domains) with CALM (PubMed:9490638).

Interacts with RHOA (PubMed:26529257).

Interacts (via Rho-GAP domain) with ROBO1; this inhibits the interaction with RHOA and the stimulation of RHOA GTPase activity, and thereby increases the levels of active RHOA (PubMed:26529257).

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
110734, 36 interactors

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...
ELMi
Q13459

Protein interaction database and analysis system

More...
IntActi
Q13459, 30 interactors

Molecular INTeraction database

More...
MINTi
Q13459

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000471457

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q13459, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

12157
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q13459

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini15 – 114Ras-associatingPROSITE-ProRule annotationAdd BLAST100
Domaini146 – 953Myosin motorPROSITE-ProRule annotationAdd BLAST808
Domaini957 – 977IQ 1PROSITE-ProRule annotationAdd BLAST21
Domaini979 – 1000IQ 2PROSITE-ProRule annotationAdd BLAST22
Domaini1001 – 1023IQ 3PROSITE-ProRule annotationAdd BLAST23
Domaini1024 – 1053IQ 4PROSITE-ProRule annotationAdd BLAST30
Domaini1703 – 1888Rho-GAPPROSITE-ProRule annotationAdd BLAST186

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni844 – 855Actin-bindingCuratedAdd BLAST12
Regioni940 – 1044Neck or regulatory domainCuratedAdd BLAST105
Regioni1045 – 2157TailCuratedAdd BLAST1113
Regioni1739 – 1744Interaction with RHOA1 Publication6

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1046 – 1071Sequence analysisAdd BLAST26
Coiled coili1880 – 1901Sequence analysisAdd BLAST22
Coiled coili1959 – 1989Sequence analysisAdd BLAST31

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri1632 – 1681Phorbol-ester/DAG-typePROSITE-ProRule annotationAdd BLAST50

Keywords - Domaini

Coiled coil, Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1453, Eukaryota
KOG4229, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156845

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000192_2_2_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q13459

KEGG Orthology (KO)

More...
KOi
K10360

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q13459

TreeFam database of animal gene trees

More...
TreeFami
TF319651

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00029, C1, 1 hit
cd01385, MYSc_Myo9, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.555.10, 1 hit
3.40.850.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000048, IQ_motif_EF-hand-BS
IPR036961, Kinesin_motor_dom_sf
IPR028557, MYO9B
IPR001609, Myosin_head_motor_dom
IPR036023, MYSc_Myo9
IPR027417, P-loop_NTPase
IPR002219, PE/DAG-bd
IPR000159, RA_dom
IPR008936, Rho_GTPase_activation_prot
IPR000198, RhoGAP_dom
IPR029071, Ubiquitin-like_domsf

The PANTHER Classification System

More...
PANTHERi
PTHR46184:SF2, PTHR46184:SF2, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00612, IQ, 4 hits
PF00063, Myosin_head, 2 hits
PF00788, RA, 1 hit
PF00620, RhoGAP, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00193, MYOSINHEAVY

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00109, C1, 1 hit
SM00015, IQ, 4 hits
SM00242, MYSc, 1 hit
SM00314, RA, 1 hit
SM00324, RhoGAP, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48350, SSF48350, 1 hit
SSF52540, SSF52540, 2 hits
SSF54236, SSF54236, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50096, IQ, 3 hits
PS51456, MYOSIN_MOTOR, 1 hit
PS50200, RA, 1 hit
PS50238, RHOGAP, 1 hit
PS00479, ZF_DAG_PE_1, 1 hit
PS50081, ZF_DAG_PE_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 8 potential isoforms that are computationally mapped.Show allAlign All

Isoform Long (identifier: Q13459-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSVKEAGSSG RREQAAYHLH IYPQLSTTES QASCRVTATK DSTTSDVIKD
60 70 80 90 100
AIASLRLDGT KCYVLVEVKE SGGEEWVLDA NDSPVHRVLL WPRRAQDEHP
110 120 130 140 150
QEDGYYFLLQ ERNADGTIKY VHMQLVAQAT ATRRLVERGL LPRQQADFDD
160 170 180 190 200
LCNLPELTEG NLLKNLKHRF LQQKIYTYAG SILVAINPFK FLPIYNPKYV
210 220 230 240 250
KMYENQQLGK LEPHVFALAD VAYYTMLRKR VNQCIVISGE SGSGKTQSTN
260 270 280 290 300
FLIHCLTALS QKGYASGVER TILGAGPVLE AFGNAKTAHN NNSSRFGKFI
310 320 330 340 350
QVSYLESGIV RGAVVEKYLL EKSRLVSQEK DERNYHVFYY LLLGVSEEER
360 370 380 390 400
QEFQLKQPED YFYLNQHNLK IEDGEDLKHD FERLKQAMEM VGFLPATKKQ
410 420 430 440 450
IFAVLSAILY LGNVTYKKRA TGREEGLEVG PPEVLDTLSQ LLKVKREILV
460 470 480 490 500
EVLTKRKTVT VNDKLILPYS LSEAITARDS MAKSLYSALF DWIVLRINHA
510 520 530 540 550
LLNKKDVEEA VSCLSIGVLD IFGFEDFERN SFEQFCINYA NEQLQYYFNQ
560 570 580 590 600
HIFKLEQEEY QGEGITWHNI GYTDNVGCIH LISKKPTGLF YLLDEESNFP
610 620 630 640 650
HATSQTLLAK FKQQHEDNKY FLGTPVMEPA FIIQHFAGKV KYQIKDFREK
660 670 680 690 700
NMDYMRPDIV ALLRGSDSSY VRELIGMDPV AVFRWAVLRA AIRAMAVLRE
710 720 730 740 750
AGRLRAERAE KAAGMSSPGA QSHPEELPRG ASTPSEKLYR DLHNQMIKSI
760 770 780 790 800
KGLPWQGEDP RSLLQSLSRL QKPRAFILKS KGIKQKQIIP KNLLDSKSLK
810 820 830 840 850
LIISMTLHDR TTKSLLHLHK KKKPPSISAQ FQTSLNKLLE ALGKAEPFFI
860 870 880 890 900
RCIRSNAEKK ELCFDDELVL QQLRYTGMLE TVRIRRSGYS AKYTFQDFTE
910 920 930 940 950
QFQVLLPKDA QPCREVISTL LEKMKIDKRN YQIGKTKVFL KETERQALQE
960 970 980 990 1000
TLHREVVRKI LLLQSWFRMV LERRHFLQMK RAAVTIQACW RSYRVRRALE
1010 1020 1030 1040 1050
RTQAAVYLQA SWRGYWQRKL YRHQKQSIIR LQSLCRGHLQ RKSFSQMISE
1060 1070 1080 1090 1100
KQKAEEKERE ALEAARAGAE EGGQGQAAGG QQVAEQGPEP AEDGGHLASE
1110 1120 1130 1140 1150
PEVQPSDRSP LEHSSPEKEA PSPEKTLPPQ KTVAAESHEK VPSSREKRES
1160 1170 1180 1190 1200
RRQRGLEHVK FQNKHIQSCK EESALREPSR RVTQEQGVSL LEDKKESRED
1210 1220 1230 1240 1250
ETLLVVETEA ENTSQKQPTE QPQAMAVGKV SEETEKTLPS GSPRPGQLER
1260 1270 1280 1290 1300
PTSLALDSRV SPPAPGSAPE TPEDKSKPCG SPRVQEKPDS PGGSTQIQRY
1310 1320 1330 1340 1350
LDAERLASAV ELWRGKKLVA AASPSAMLSQ SLDLSDRHRA TGAALTPTEE
1360 1370 1380 1390 1400
RRTSFSTSDV SKLLPSLAKA QPAAETTDGE RSAKKPAVQK KKPGDASSLP
1410 1420 1430 1440 1450
DAGLSPGSQV DSKSTFKRLF LHKTKDKKYS LEGAEELENA VSGHVVLEAT
1460 1470 1480 1490 1500
TMKKGLEAPS GQQHRHAAGE KRTKEPGGKG KKNRNVKIGK ITVSEKWRES
1510 1520 1530 1540 1550
VFRQITNANE LKYLDEFLLN KINDLRSQKT PIESLFIEAT EKFRSNIKTM
1560 1570 1580 1590 1600
YSVPNGKIHV GYKDLMENYQ IVVSNLATER GQKDTNLVLN LFQSLLDEFT
1610 1620 1630 1640 1650
RGYTKNDFEP VKQSKAQKKK RKQERAVQEH NGHVFASYQV SIPQSCEQCL
1660 1670 1680 1690 1700
SYIWLMDKAL LCSVCKMTCH KKCVHKIQSH CSYTYGRKGE PGVEPGHFGV
1710 1720 1730 1740 1750
CVDSLTSDKA SVPIVLEKLL EHVEMHGLYT EGLYRKSGAA NRTRELRQAL
1760 1770 1780 1790 1800
QTDPAAVKLE NFPIHAITGV LKQWLRELPE PLMTFAQYGD FLRAVELPEK
1810 1820 1830 1840 1850
QEQLAAIYAV LEHLPEANHN SLERLIFHLV KVALLEDVNR MSPGALAIIF
1860 1870 1880 1890 1900
APCLLRCPDN SDPLTSMKDV LKITTCVEML IKEQMRKYKV KMEEISQLEA
1910 1920 1930 1940 1950
AESIAFRRLS LLRQNAPWPL KLGFSSPYEG VLNKSPKTRD IQEEELEVLL
1960 1970 1980 1990 2000
EEEAAGGDED REKEILIERI QSIKEEKEDI TYRLPELDPR GSDEENLDSE
2010 2020 2030 2040 2050
TSASTESLLE ERAGRGASEG PPAPALPCPG APTPSPLPTV AAPPRRRPSS
2060 2070 2080 2090 2100
FVTVRVKTPR RTPIMPTANI KLPPGLPSHL PRWAPGAREA AAPVRRREPP
2110 2120 2130 2140 2150
ARRPDQIHSV YITPGADLPV QGALEPLEED GQPPGAKRRY SDPPTYCLPP

ASGQTNG
Length:2,157
Mass (Da):243,401
Last modified:March 8, 2011 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA3E72CAB759CD5FD
GO
Isoform Short (identifier: Q13459-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     2021-2022: PP → QY
     2023-2157: Missing.

Show »
Length:2,022
Mass (Da):229,143
Checksum:iD0E47A7EAF86A929
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
M0R0P8M0R0P8_HUMAN
Unconventional myosin-IXb
MYO9B
2,157Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0R300M0R300_HUMAN
Unconventional myosin-IXb
MYO9B
2,071Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0QZY4M0QZY4_HUMAN
Unconventional myosin-IXb
MYO9B
154Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0R2J3M0R2J3_HUMAN
Unconventional myosin-IXb
MYO9B
174Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0QXP0M0QXP0_HUMAN
Unconventional myosin-IXb
MYO9B
195Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0R332M0R332_HUMAN
Unconventional myosin-IXb
MYO9B
195Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0R240M0R240_HUMAN
Unconventional myosin-IXb
MYO9B
174Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0QXX1M0QXX1_HUMAN
Unconventional myosin-IXb
MYO9B
59Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAC50402 differs from that shown. The C-terminal sequence from position 1917 onwards appears to be not correctly spliced.Curated
The sequence BAA92132 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti237 – 238IS → YP in AAC50402 (PubMed:8907710).Curated2
Sequence conflicti276G → C in AAC50402 (PubMed:8907710).Curated1
Sequence conflicti1011S → A in AAC50402 (PubMed:8907710).Curated1
Sequence conflicti1693V → A in AAC50402 (PubMed:8907710).Curated1
Sequence conflicti1946L → P in BAA92132 (PubMed:9490638).Curated1
Sequence conflicti2039 – 2044TVAAPP → PWPPLH in AAC26597 (PubMed:10580159).Curated6
Sequence conflicti2048P → L in AAC26597 (PubMed:10580159).Curated1
Sequence conflicti2066P → S in AAC26597 (PubMed:10580159).Curated1
Sequence conflicti2156 – 2157NG → MAESHS in AAC26597 (PubMed:10580159).Curated2

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0033612021 – 2022PP → QY in isoform Short. 1 Publication2
Alternative sequenceiVSP_0033622023 – 2157Missing in isoform Short. 1 PublicationAdd BLAST135

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U42391 mRNA Translation: AAC50402.1 Sequence problems.
AC020913 Genomic DNA No translation available.
AC020908 Genomic DNA No translation available.
AF143684 mRNA Translation: AAF00119.1
AF020267 mRNA Translation: AAC26597.1
AK002201 mRNA Translation: BAA92132.1 Different initiation.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS46010.1 [Q13459-2]

NCBI Reference Sequences

More...
RefSeqi
NP_004136.2, NM_004145.3 [Q13459-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000397274; ENSP00000380444; ENSG00000099331 [Q13459-2]
ENST00000595618; ENSP00000471457; ENSG00000099331 [Q13459-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
4650

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:4650

UCSC genome browser

More...
UCSCi
uc002nfi.3, human [Q13459-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Wikipedia

MYO9B entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U42391 mRNA Translation: AAC50402.1 Sequence problems.
AC020913 Genomic DNA No translation available.
AC020908 Genomic DNA No translation available.
AF143684 mRNA Translation: AAF00119.1
AF020267 mRNA Translation: AAC26597.1
AK002201 mRNA Translation: BAA92132.1 Different initiation.
CCDSiCCDS46010.1 [Q13459-2]
RefSeqiNP_004136.2, NM_004145.3 [Q13459-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5C5SX-ray2.20A/B/C/D1691-1916[»]
5HPYX-ray2.40A/D1691-1916[»]
SMRiQ13459
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi110734, 36 interactors
ELMiQ13459
IntActiQ13459, 30 interactors
MINTiQ13459
STRINGi9606.ENSP00000471457

PTM databases

iPTMnetiQ13459
MetOSiteiQ13459
PhosphoSitePlusiQ13459

Polymorphism and mutation databases

BioMutaiMYO9B
DMDMi325511388

Proteomic databases

CPTACiCPTAC-981
CPTAC-982
EPDiQ13459
jPOSTiQ13459
MassIVEiQ13459
MaxQBiQ13459
PaxDbiQ13459
PeptideAtlasiQ13459
PRIDEiQ13459
ProteomicsDBi59458 [Q13459-1]
59459 [Q13459-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
7715, 104 antibodies

Genome annotation databases

EnsembliENST00000397274; ENSP00000380444; ENSG00000099331 [Q13459-2]
ENST00000595618; ENSP00000471457; ENSG00000099331 [Q13459-2]
GeneIDi4650
KEGGihsa:4650
UCSCiuc002nfi.3, human [Q13459-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
4650
DisGeNETi4650
EuPathDBiHostDB:ENSG00000099331.13

GeneCards: human genes, protein and diseases

More...
GeneCardsi
MYO9B
HGNCiHGNC:7609, MYO9B
HPAiENSG00000099331, Low tissue specificity
MalaCardsiMYO9B
MIMi602129, gene
609753, phenotype
neXtProtiNX_Q13459
OpenTargetsiENSG00000099331

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1453, Eukaryota
KOG4229, Eukaryota
GeneTreeiENSGT00940000156845
HOGENOMiCLU_000192_2_2_1
InParanoidiQ13459
KOiK10360
PhylomeDBiQ13459
TreeFamiTF319651

Enzyme and pathway databases

PathwayCommonsiQ13459
ReactomeiR-HSA-194840, Rho GTPase cycle
R-HSA-2029482, Regulation of actin dynamics for phagocytic cup formation
R-HSA-8985586, SLIT2:ROBO1 increases RHOA activity
R-HSA-9664422, FCGR3A-mediated phagocytosis
SIGNORiQ13459

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
4650, 30 hits in 884 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
MYO9B, human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
MYO9B

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
4650
PharosiQ13459, Tbio

Protein Ontology

More...
PROi
PR:Q13459
RNActiQ13459, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000099331, Expressed in right testis and 219 other tissues
ExpressionAtlasiQ13459, baseline and differential
GenevisibleiQ13459, HS

Family and domain databases

CDDicd00029, C1, 1 hit
cd01385, MYSc_Myo9, 1 hit
Gene3Di1.10.555.10, 1 hit
3.40.850.10, 2 hits
InterProiView protein in InterPro
IPR000048, IQ_motif_EF-hand-BS
IPR036961, Kinesin_motor_dom_sf
IPR028557, MYO9B
IPR001609, Myosin_head_motor_dom
IPR036023, MYSc_Myo9
IPR027417, P-loop_NTPase
IPR002219, PE/DAG-bd
IPR000159, RA_dom
IPR008936, Rho_GTPase_activation_prot
IPR000198, RhoGAP_dom
IPR029071, Ubiquitin-like_domsf
PANTHERiPTHR46184:SF2, PTHR46184:SF2, 1 hit
PfamiView protein in Pfam
PF00612, IQ, 4 hits
PF00063, Myosin_head, 2 hits
PF00788, RA, 1 hit
PF00620, RhoGAP, 1 hit
PRINTSiPR00193, MYOSINHEAVY
SMARTiView protein in SMART
SM00109, C1, 1 hit
SM00015, IQ, 4 hits
SM00242, MYSc, 1 hit
SM00314, RA, 1 hit
SM00324, RhoGAP, 1 hit
SUPFAMiSSF48350, SSF48350, 1 hit
SSF52540, SSF52540, 2 hits
SSF54236, SSF54236, 1 hit
PROSITEiView protein in PROSITE
PS50096, IQ, 3 hits
PS51456, MYOSIN_MOTOR, 1 hit
PS50200, RA, 1 hit
PS50238, RHOGAP, 1 hit
PS00479, ZF_DAG_PE_1, 1 hit
PS50081, ZF_DAG_PE_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMYO9B_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q13459
Secondary accession number(s): O75314, Q9NUJ2, Q9UHN0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: March 8, 2011
Last modified: August 12, 2020
This is version 204 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again