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Protein

Transmembrane emp24 domain-containing protein 1

Gene

TMED1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Potential role in vesicular protein trafficking, mainly in the early secretory pathway. May act as a cargo receptor at the lumenal side for incorporation of secretory cargo molecules into transport vesicles and may be involved in vesicle coat formation at the cytoplasmic side.

Miscellaneous

Found only in very low concentrations in the endoplasmic reticulum, Golgi apparatus and endoplasmic reticulum-Golgi intermediate compartment compared to other members of the EMP24/GP25L family.

GO - Molecular functioni

  • signaling receptor binding Source: ProtInc

GO - Biological processi

Keywordsi

Biological processProtein transport, Transport

Protein family/group databases

TCDBi9.B.188.1.1 the transmembrane emp24 domain-containing protein (tmed) family

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane emp24 domain-containing protein 1
Alternative name(s):
Interleukin-1 receptor-like 1 ligand
Putative T1/ST2 receptor-binding protein
p24 family protein gamma-1
Short name:
Tp24
Short name:
p24gamma1
Gene namesi
Name:TMED1
Synonyms:IL1RL1L, IL1RL1LG
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000099203.6
HGNCiHGNC:17291 TMED1
MIMi605395 gene
neXtProtiNX_Q13445

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini24 – 194ExtracellularSequence analysisAdd BLAST171
Transmembranei195 – 215HelicalSequence analysisAdd BLAST21
Topological domaini216 – 227CytoplasmicSequence analysisAdd BLAST12

Keywords - Cellular componenti

Cell membrane, Endoplasmic reticulum, Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi11018
OpenTargetsiENSG00000099203
PharmGKBiPA134972147

Polymorphism and mutation databases

DMDMi74739789

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Combined sources1 PublicationAdd BLAST23
ChainiPRO_000024801924 – 227Transmembrane emp24 domain-containing protein 1Add BLAST204

Proteomic databases

EPDiQ13445
MaxQBiQ13445
PaxDbiQ13445
PeptideAtlasiQ13445
PRIDEiQ13445
ProteomicsDBi59453
TopDownProteomicsiQ13445

PTM databases

iPTMnetiQ13445
PhosphoSitePlusiQ13445
SwissPalmiQ13445

Expressioni

Tissue specificityi

Widely expressed.1 Publication

Gene expression databases

BgeeiENSG00000099203 Expressed in 220 organ(s), highest expression level in epithelium of bronchus
CleanExiHS_TMED1
ExpressionAtlasiQ13445 baseline and differential
GenevisibleiQ13445 HS

Organism-specific databases

HPAiHPA018507

Interactioni

Subunit structurei

Homodimer in endoplasmic reticulum, endoplasmic reticulum-Golgi intermediate compartment and cis-Golgi network. May interact with IL1RL1.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi116208, 20 interactors
IntActiQ13445, 10 interactors
MINTiQ13445
STRINGi9606.ENSP00000214869

Structurei

3D structure databases

ProteinModelPortaliQ13445
SMRiQ13445
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini43 – 125GOLDPROSITE-ProRule annotationAdd BLAST83

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili145 – 170Sequence analysisAdd BLAST26

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi218 – 227COPI vesicle coat-bindingSequence analysis10
Motifi218 – 219COPII vesicle coat-bindingSequence analysis2

Sequence similaritiesi

Belongs to the EMP24/GP25L family.Curated

Keywords - Domaini

Coiled coil, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3287 Eukaryota
ENOG410Z18S LUCA
GeneTreeiENSGT00670000097656
HOGENOMiHOG000039809
HOVERGENiHBG000271
InParanoidiQ13445
KOiK20348
OMAiRSRQMQT
OrthoDBiEOG091G0RNG
PhylomeDBiQ13445
TreeFamiTF313000

Family and domain databases

InterProiView protein in InterPro
IPR009038 GOLD_dom
IPR036598 GOLD_dom_sf
IPR015720 TMP21-related
PANTHERiPTHR22811 PTHR22811, 1 hit
PfamiView protein in Pfam
PF01105 EMP24_GP25L, 1 hit
SMARTiView protein in SMART
SM01190 EMP24_GP25L, 1 hit
SUPFAMiSSF101576 SSF101576, 1 hit
PROSITEiView protein in PROSITE
PS50866 GOLD, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.Show allAlign All

Q13445-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MMAAGAALAL ALWLLMPPVE VGGAGPPPIQ DGEFTFLLPA GRKQCFYQSA
60 70 80 90 100
PANASLETEY QVIGGAGLDV DFTLESPQGV LLVSESRKAD GVHTVEPTEA
110 120 130 140 150
GDYKLCFDNS FSTISEKLVF FELIFDSLQD DEEVEGWAEA VEPEEMLDVK
160 170 180 190 200
MEDIKESIET MRTRLERSIQ MLTLLRAFEA RDRNLQEGNL ERVNFWSAVN
210 220
VAVLLLVAVL QVCTLKRFFQ DKRPVPT
Length:227
Mass (Da):25,206
Last modified:November 1, 1996 - v1
Checksum:i058C5274E05F8575
GO

Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
K7EQ63K7EQ63_HUMAN
Transmembrane emp24 domain-containi...
TMED1
191Annotation score:
K7EIN4K7EIN4_HUMAN
Transmembrane emp24 domain-containi...
TMED1
82Annotation score:
K7ERK5K7ERK5_HUMAN
Transmembrane emp24 domain-containi...
TMED1
185Annotation score:
K7ES06K7ES06_HUMAN
Transmembrane emp24 domain-containi...
TMED1
95Annotation score:
K7ER03K7ER03_HUMAN
Transmembrane emp24 domain-containi...
TMED1
74Annotation score:
K7EIR1K7EIR1_HUMAN
Transmembrane emp24 domain-containi...
TMED1
65Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_036533102D → N in a breast cancer sample; somatic mutation. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U41804 mRNA Translation: AAC50419.1
AC007229 Genomic DNA Translation: AAD23605.1
BC002443 mRNA Translation: AAH02443.1
CCDSiCCDS12249.1
RefSeqiNP_006849.1, NM_006858.3
UniGeneiHs.211463
Hs.515139
Hs.661691

Genome annotation databases

EnsembliENST00000214869; ENSP00000214869; ENSG00000099203
GeneIDi11018
KEGGihsa:11018
UCSCiuc002mpy.5 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U41804 mRNA Translation: AAC50419.1
AC007229 Genomic DNA Translation: AAD23605.1
BC002443 mRNA Translation: AAH02443.1
CCDSiCCDS12249.1
RefSeqiNP_006849.1, NM_006858.3
UniGeneiHs.211463
Hs.515139
Hs.661691

3D structure databases

ProteinModelPortaliQ13445
SMRiQ13445
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116208, 20 interactors
IntActiQ13445, 10 interactors
MINTiQ13445
STRINGi9606.ENSP00000214869

Protein family/group databases

TCDBi9.B.188.1.1 the transmembrane emp24 domain-containing protein (tmed) family

PTM databases

iPTMnetiQ13445
PhosphoSitePlusiQ13445
SwissPalmiQ13445

Polymorphism and mutation databases

DMDMi74739789

Proteomic databases

EPDiQ13445
MaxQBiQ13445
PaxDbiQ13445
PeptideAtlasiQ13445
PRIDEiQ13445
ProteomicsDBi59453
TopDownProteomicsiQ13445

Protocols and materials databases

DNASUi11018
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000214869; ENSP00000214869; ENSG00000099203
GeneIDi11018
KEGGihsa:11018
UCSCiuc002mpy.5 human

Organism-specific databases

CTDi11018
DisGeNETi11018
EuPathDBiHostDB:ENSG00000099203.6
GeneCardsiTMED1
HGNCiHGNC:17291 TMED1
HPAiHPA018507
MIMi605395 gene
neXtProtiNX_Q13445
OpenTargetsiENSG00000099203
PharmGKBiPA134972147
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3287 Eukaryota
ENOG410Z18S LUCA
GeneTreeiENSGT00670000097656
HOGENOMiHOG000039809
HOVERGENiHBG000271
InParanoidiQ13445
KOiK20348
OMAiRSRQMQT
OrthoDBiEOG091G0RNG
PhylomeDBiQ13445
TreeFamiTF313000

Miscellaneous databases

GeneWikiiTMED1
GenomeRNAii11018
PROiPR:Q13445
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000099203 Expressed in 220 organ(s), highest expression level in epithelium of bronchus
CleanExiHS_TMED1
ExpressionAtlasiQ13445 baseline and differential
GenevisibleiQ13445 HS

Family and domain databases

InterProiView protein in InterPro
IPR009038 GOLD_dom
IPR036598 GOLD_dom_sf
IPR015720 TMP21-related
PANTHERiPTHR22811 PTHR22811, 1 hit
PfamiView protein in Pfam
PF01105 EMP24_GP25L, 1 hit
SMARTiView protein in SMART
SM01190 EMP24_GP25L, 1 hit
SUPFAMiSSF101576 SSF101576, 1 hit
PROSITEiView protein in PROSITE
PS50866 GOLD, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTMED1_HUMAN
AccessioniPrimary (citable) accession number: Q13445
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 5, 2006
Last sequence update: November 1, 1996
Last modified: November 7, 2018
This is version 139 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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