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Protein

28 kDa heat- and acid-stable phosphoprotein

Gene

PDAP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Enhances PDGFA-stimulated cell growth in fibroblasts, but inhibits the mitogenic effect of PDGFB.By similarity

GO - Molecular functioni

GO - Biological processi

  • cell proliferation Source: ProtInc
  • neutrophil degranulation Source: Reactome
  • signal transduction Source: ProtInc

Enzyme and pathway databases

ReactomeiR-HSA-6798695 Neutrophil degranulation

Names & Taxonomyi

Protein namesi
Recommended name:
28 kDa heat- and acid-stable phosphoprotein
Alternative name(s):
PDGF-associated protein
Short name:
PAP
PDGFA-associated protein 1
Short name:
PAP1
Gene namesi
Name:PDAP1
Synonyms:HASPP28
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000106244.12
HGNCiHGNC:14634 PDAP1
MIMi607075 gene
neXtProtiNX_Q13442

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi11333
OpenTargetsiENSG00000106244
PharmGKBiPA33102

Polymorphism and mutation databases

BioMutaiPDAP1
DMDMi2498464

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000838971 – 18128 kDa heat- and acid-stable phosphoproteinAdd BLAST181

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei18PhosphothreonineCombined sources1
Modified residuei19PhosphoserineCombined sources1
Cross-linki52Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei57PhosphoserineCombined sources1
Modified residuei60PhosphoserineCombined sources1
Modified residuei63PhosphoserineCombined sources1
Modified residuei70PhosphotyrosineBy similarity1
Modified residuei126N6-methyllysineCombined sources1
Modified residuei132N6-acetyllysineCombined sources1
Modified residuei164N6-acetyllysineBy similarity1
Modified residuei176PhosphoserineCombined sources1
Modified residuei178PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ13442
MaxQBiQ13442
PaxDbiQ13442
PeptideAtlasiQ13442
PRIDEiQ13442
ProteomicsDBi59439
TopDownProteomicsiQ13442

PTM databases

iPTMnetiQ13442
PhosphoSitePlusiQ13442

Miscellaneous databases

PMAP-CutDBiQ13442

Expressioni

Gene expression databases

BgeeiENSG00000106244 Expressed in 228 organ(s), highest expression level in testis
CleanExiHS_PDAP1
ExpressionAtlasiQ13442 baseline and differential
GenevisibleiQ13442 HS

Organism-specific databases

HPAiCAB021103
HPA050294
HPA060836

Interactioni

Protein-protein interaction databases

BioGridi116461, 22 interactors
IntActiQ13442, 8 interactors
STRINGi9606.ENSP00000222968

Structurei

3D structure databases

ProteinModelPortaliQ13442
SMRiQ13442
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PDAP1 family.Curated

Phylogenomic databases

eggNOGiKOG3375 Eukaryota
ENOG4111T3A LUCA
GeneTreeiENSGT00390000018509
HOGENOMiHOG000241539
HOVERGENiHBG000319
InParanoidiQ13442
OMAiKHFSRDL
OrthoDBiEOG091G16GX
PhylomeDBiQ13442
TreeFamiTF324338

Family and domain databases

InterProiView protein in InterPro
IPR019380 Casein_kinase_sb_PP28
PfamiView protein in Pfam
PF10252 PP28, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q13442-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPKGGRKGGH KGRARQYTSP EEIDAQLQAE KQKAREEEEQ KEGGDGAAGD
60 70 80 90 100
PKKEKKSLDS DESEDEEDDY QQKRKGVEGL IDIENPNRVA QTTKKVTQLD
110 120 130 140 150
LDGPKELSRR EREEIEKQKA KERYMKMHLA GKTEQAKADL ARLAIIRKQR
160 170 180
EEAARKKEEE RKAKDDATLS GKRMQSLSLN K
Length:181
Mass (Da):20,630
Last modified:November 1, 1996 - v1
Checksum:iF97914C7920ABAB3
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8WBW6F8WBW6_HUMAN
28 kDa heat- and acid-stable phosph...
PDAP1
39Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti1M → MI in AAB07135 (Ref. 5) Curated1
Sequence conflicti13R → W in AAB07135 (Ref. 5) Curated1
Sequence conflicti25A → T in AAB07135 (Ref. 5) Curated1
Sequence conflicti29A → S in AAB07135 (Ref. 5) Curated1
Sequence conflicti67E → D in AAB07135 (Ref. 5) Curated1
Sequence conflicti80L → F in AAB07135 (Ref. 5) Curated1
Sequence conflicti126K → R in AAB07135 (Ref. 5) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U41745 mRNA Translation: AAC50462.1
AC004922 Genomic DNA Translation: AAF03506.1
CH471091 Genomic DNA Translation: EAW76675.1
CH471091 Genomic DNA Translation: EAW76676.1
BC000684 mRNA Translation: AAH00684.1
BC007873 mRNA Translation: AAH07873.1
U65960 Genomic DNA Translation: AAB07135.1
CCDSiCCDS5662.1
RefSeqiNP_055706.1, NM_014891.6
UniGeneiHs.632296

Genome annotation databases

EnsembliENST00000350498; ENSP00000222968; ENSG00000106244
GeneIDi11333
KEGGihsa:11333
UCSCiuc003uqe.5 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U41745 mRNA Translation: AAC50462.1
AC004922 Genomic DNA Translation: AAF03506.1
CH471091 Genomic DNA Translation: EAW76675.1
CH471091 Genomic DNA Translation: EAW76676.1
BC000684 mRNA Translation: AAH00684.1
BC007873 mRNA Translation: AAH07873.1
U65960 Genomic DNA Translation: AAB07135.1
CCDSiCCDS5662.1
RefSeqiNP_055706.1, NM_014891.6
UniGeneiHs.632296

3D structure databases

ProteinModelPortaliQ13442
SMRiQ13442
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116461, 22 interactors
IntActiQ13442, 8 interactors
STRINGi9606.ENSP00000222968

PTM databases

iPTMnetiQ13442
PhosphoSitePlusiQ13442

Polymorphism and mutation databases

BioMutaiPDAP1
DMDMi2498464

Proteomic databases

EPDiQ13442
MaxQBiQ13442
PaxDbiQ13442
PeptideAtlasiQ13442
PRIDEiQ13442
ProteomicsDBi59439
TopDownProteomicsiQ13442

Protocols and materials databases

DNASUi11333
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000350498; ENSP00000222968; ENSG00000106244
GeneIDi11333
KEGGihsa:11333
UCSCiuc003uqe.5 human

Organism-specific databases

CTDi11333
DisGeNETi11333
EuPathDBiHostDB:ENSG00000106244.12
GeneCardsiPDAP1
HGNCiHGNC:14634 PDAP1
HPAiCAB021103
HPA050294
HPA060836
MIMi607075 gene
neXtProtiNX_Q13442
OpenTargetsiENSG00000106244
PharmGKBiPA33102
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3375 Eukaryota
ENOG4111T3A LUCA
GeneTreeiENSGT00390000018509
HOGENOMiHOG000241539
HOVERGENiHBG000319
InParanoidiQ13442
OMAiKHFSRDL
OrthoDBiEOG091G16GX
PhylomeDBiQ13442
TreeFamiTF324338

Enzyme and pathway databases

ReactomeiR-HSA-6798695 Neutrophil degranulation

Miscellaneous databases

ChiTaRSiPDAP1 human
GeneWikiiPDAP1
GenomeRNAii11333
PMAP-CutDBiQ13442
PROiPR:Q13442
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000106244 Expressed in 228 organ(s), highest expression level in testis
CleanExiHS_PDAP1
ExpressionAtlasiQ13442 baseline and differential
GenevisibleiQ13442 HS

Family and domain databases

InterProiView protein in InterPro
IPR019380 Casein_kinase_sb_PP28
PfamiView protein in Pfam
PF10252 PP28, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiHAP28_HUMAN
AccessioniPrimary (citable) accession number: Q13442
Secondary accession number(s): D6W5S5, Q92906
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: September 12, 2018
This is version 146 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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