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Entry version 190 (22 Apr 2020)
Sequence version 1 (01 Nov 1996)
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Protein

Golgin subfamily A member 4

Gene

GOLGA4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in vesicular trafficking at the Golgi apparatus level. May play a role in delivery of transport vesicles containing GPI-linked proteins from the trans-Golgi network through its interaction with MACF1. Involved in endosome-to-Golgi trafficking (PubMed:29084197).2 Publications

Miscellaneous

Antibodies against GOLGA4 are present in sera from patients with Sjoegren syndrome. Sera from patients with Sjoegren syndrome often contain antibodies that react with normal components of the Golgi complex.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • GTPase binding Source: UniProtKB

GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-6811440 Retrograde transport at the Trans-Golgi-Network

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Golgin subfamily A member 4
Alternative name(s):
256 kDa golgin
Golgin-245
Protein 72.1
Trans-Golgi p230
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:GOLGA4
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:4427 GOLGA4

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
602509 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q13439

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm, Golgi apparatus, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi2F → A: Loss of TBC1D23-binding. 1 Publication1
Mutagenesisi2177Y → A: Loss of localization at the Golgi apparatus. Loss of ARL1-binding. 4 Publications1
Mutagenesisi2177Y → F: No effect on localization at the Golgi apparatus. 2 Publications1
Mutagenesisi2181V → A: Abolishes Golgi localization. 1 Publication1
Mutagenesisi2183F → A: Abolishes Golgi localization. 1 Publication1
Mutagenesisi2185Y → A: Loss of localization at the Golgi apparatus. 1 Publication1
Mutagenesisi2186M → A: Abolishes Golgi localization. 1 Publication1
Mutagenesisi2193T → A: Abolishes Golgi localization. 1 Publication1
Mutagenesisi2194M → A: Abolishes Golgi localization. 1 Publication1
Mutagenesisi2197V → A: Abolishes Golgi localization. 1 Publication1
Mutagenesisi2198I → A: Abolishes Golgi localization. 1 Publication1
Mutagenesisi2202L → A: Abolishes Golgi localization. 1 Publication1
Mutagenesisi2204F → A: Abolishes Golgi localization. 1 Publication1
Mutagenesisi2212I → A: Abolishes Golgi localization. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
2803

Open Targets

More...
OpenTargetsi
ENSG00000144674

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA28808

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q13439 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
GOLGA4

Domain mapping of disease mutations (DMDM)

More...
DMDMi
12643718

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001900591 – 2230Golgin subfamily A member 4Add BLAST2230

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei10PhosphoserineCombined sources1
Modified residuei39PhosphothreonineBy similarity1
Modified residuei41PhosphoserineCombined sources1
Modified residuei71PhosphoserineCombined sources1
Modified residuei78PhosphoserineCombined sources1
Modified residuei89PhosphoserineCombined sources1
Modified residuei266PhosphoserineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi585N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi1612N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Modified residuei2223PhosphothreonineCombined sources1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q13439

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q13439

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q13439

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q13439

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q13439

PeptideAtlas

More...
PeptideAtlasi
Q13439

PRoteomics IDEntifications database

More...
PRIDEi
Q13439

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
30188
59436 [Q13439-1]
59437 [Q13439-3]
59438 [Q13439-4]

PTM databases

GlyConnect protein glycosylation platform

More...
GlyConnecti
690

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q13439

MetOSite database of methionine sulfoxide sites

More...
MetOSitei
Q13439

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q13439

UniCarbKB; an annotated and curated database of glycan structures

More...
UniCarbKBi
Q13439

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000144674 Expressed in biceps brachii and 239 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q13439 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q13439 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000144674 Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer (PubMed:14718928).

Interacts with RAB6A (PubMed:10209123).

Interacts with GTP-bound ARL1 and ARL3 (PubMed:11303027, PubMed:14580338, PubMed:14718928).

Interacts with MACF1 (PubMed:15265687). Directly interacts with TBC1D23 (PubMed:29084197).

Interacts with FAM91A1; this interaction may be mediated by TBC1D23 (PubMed:29084197).

6 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
109065, 50 interactors

Protein interaction database and analysis system

More...
IntActi
Q13439, 46 interactors

Molecular INTeraction database

More...
MINTi
Q13439

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000349305

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q13439 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

12230
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q13439

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q13439

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini2168 – 2215GRIPPROSITE-ProRule annotationAdd BLAST48

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni133 – 203Interaction with MACF11 PublicationAdd BLAST71

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili133 – 2185Sequence analysisAdd BLAST2053

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi252 – 2096Glu-richAdd BLAST1845

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Extended rod-like protein with coiled-coil domains.

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IEA5 Eukaryota
ENOG410XQQG LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00730000111139

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_001994_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q13439

KEGG Orthology (KO)

More...
KOi
K20283

Identification of Orthologs from Complete Genome Data

More...
OMAi
DEFRNQG

Database of Orthologous Groups

More...
OrthoDBi
663248at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q13439

TreeFam database of animal gene trees

More...
TreeFami
TF325082

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000237 GRIP_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01465 GRIP, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00755 Grip, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50913 GRIP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Note: Additional isoforms seem to exist.

This entry has 4 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q13439-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MFKKLKQKIS EEQQQLQQAL APAQASSNSS TPTRMRSRTS SFTEQLDEGT
60 70 80 90 100
PNRESGDTQS FAQKLQLRVP SVESLFRSPI KESLFRSSSK ESLVRTSSRE
110 120 130 140 150
SLNRLDLDSS TASFDPPSDM DSEAEDLVGN SDSLNKEQLI QRLRRMERSL
160 170 180 190 200
SSYRGKYSEL VTAYQMLQRE KKKLQGILSQ SQDKSLRRIA ELREELQMDQ
210 220 230 240 250
QAKKHLQEEF DASLEEKDQY ISVLQTQVSL LKQRLRNGPM NVDVLKPLPQ
260 270 280 290 300
LEPQAEVFTK EENPESDGEP VVEDGTSVKT LETLQQRVKR QENLLKRCKE
310 320 330 340 350
TIQSHKEQCT LLTSEKEALQ EQLDERLQEL EKIKDLHMAE KTKLITQLRD
360 370 380 390 400
AKNLIEQLEQ DKGMVIAETK RQMHETLEMK EEEIAQLRSR IKQMTTQGEE
410 420 430 440 450
LREQKEKSER AAFEELEKAL STAQKTEEAR RKLKAEMDEQ IKTIEKTSEE
460 470 480 490 500
ERISLQQELS RVKQEVVDVM KKSSEEQIAK LQKLHEKELA RKEQELTKKL
510 520 530 540 550
QTREREFQEQ MKVALEKSQS EYLKISQEKE QQESLALEEL ELQKKAILTE
560 570 580 590 600
SENKLRDLQQ EAETYRTRIL ELESSLEKSL QENKNQSKDL AVHLEAEKNK
610 620 630 640 650
HNKEITVMVE KHKTELESLK HQQDALWTEK LQVLKQQYQT EMEKLREKCE
660 670 680 690 700
QEKETLLKDK EIIFQAHIEE MNEKTLEKLD VKQTELESLS SELSEVLKAR
710 720 730 740 750
HKLEEELSVL KDQTDKMKQE LEAKMDEQKN HHQQQVDSII KEHEVSIQRT
760 770 780 790 800
EKALKDQINQ LELLLKERDK HLKEHQAHVE NLEADIKRSE GELQQASAKL
810 820 830 840 850
DVFQSYQSAT HEQTKAYEEQ LAQLQQKLLD LETERILLTK QVAEVEAQKK
860 870 880 890 900
DVCTELDAHK IQVQDLMQQL EKQNSEMEQK VKSLTQVYES KLEDGNKEQE
910 920 930 940 950
QTKQILVEKE NMILQMREGQ KKEIEILTQK LSAKEDSIHI LNEEYETKFK
960 970 980 990 1000
NQEKKMEKVK QKAKEMQETL KKKLLDQEAK LKKELENTAL ELSQKEKQFN
1010 1020 1030 1040 1050
AKMLEMAQAN SAGISDAVSR LETNQKEQIE SLTEVHRREL NDVISIWEKK
1060 1070 1080 1090 1100
LNQQAEELQE IHEIQLQEKE QEVAELKQKI LLFGCEKEEM NKEITWLKEE
1110 1120 1130 1140 1150
GVKQDTTLNE LQEQLKQKSA HVNSLAQDET KLKAHLEKLE VDLNKSLKEN
1160 1170 1180 1190 1200
TFLQEQLVEL KMLAEEDKRK VSELTSKLKT TDEEFQSLKS SHEKSNKSLE
1210 1220 1230 1240 1250
DKSLEFKKLS EELAIQLDIC CKKTEALLEA KTNELINISS SKTNAILSRI
1260 1270 1280 1290 1300
SHCQHRTTKV KEALLIKTCT VSELEAQLRQ LTEEQNTLNI SFQQATHQLE
1310 1320 1330 1340 1350
EKENQIKSMK ADIESLVTEK EALQKEGGNQ QQAASEKESC ITQLKKELSE
1360 1370 1380 1390 1400
NINAVTLMKE ELKEKKVEIS SLSKQLTDLN VQLQNSISLS EKEAAISSLR
1410 1420 1430 1440 1450
KQYDEEKCEL LDQVQDLSFK VDTLSKEKIS ALEQVDDWSN KFSEWKKKAQ
1460 1470 1480 1490 1500
SRFTQHQNTV KELQIQLELK SKEAYEKDEQ INLLKEELDQ QNKRFDCLKG
1510 1520 1530 1540 1550
EMEDDKSKME KKESNLETEL KSQTARIMEL EDHITQKTIE IESLNEVLKN
1560 1570 1580 1590 1600
YNQQKDIEHK ELVQKLQHFQ ELGEEKDNRV KEAEEKILTL ENQVYSMKAE
1610 1620 1630 1640 1650
LETKKKELEH VNLSVKSKEE ELKALEDRLE SESAAKLAEL KRKAEQKIAA
1660 1670 1680 1690 1700
IKKQLLSQME EKEEQYKKGT ESHLSELNTK LQEREREVHI LEEKLKSVES
1710 1720 1730 1740 1750
SQSETLIVPR SAKNVAAYTE QEEADSQGCV QKTYEEKISV LQRNLTEKEK
1760 1770 1780 1790 1800
LLQRVGQEKE ETVSSHFEMR CQYQERLIKL EHAEAKQHED QSMIGHLQEE
1810 1820 1830 1840 1850
LEEKNKKYSL IVAQHVEKEG GKNNIQAKQN LENVFDDVQK TLQEKELTCQ
1860 1870 1880 1890 1900
ILEQKIKELD SCLVRQKEVH RVEMEELTSK YEKLQALQQM DGRNKPTELL
1910 1920 1930 1940 1950
EENTEEKSKS HLVQPKLLSN MEAQHNDLEF KLAGAEREKQ KLGKEIVRLQ
1960 1970 1980 1990 2000
KDLRMLRKEH QQELEILKKE YDQEREEKIK QEQEDLELKH NSTLKQLMRE
2010 2020 2030 2040 2050
FNTQLAQKEQ ELEMTIKETI NKAQEVEAEL LESHQEETNQ LLKKIAEKDD
2060 2070 2080 2090 2100
DLKRTAKRYE EILDAREEEM TAKVRDLQTQ LEELQKKYQQ KLEQEENPGN
2110 2120 2130 2140 2150
DNVTIMELQT QLAQKTTLIS DSKLKEQEFR EQIHNLEDRL KKYEKNVYAT
2160 2170 2180 2190 2200
TVGTPYKGGN LYHTDVSLFG EPTEFEYLRK VLFEYMMGRE TKTMAKVITT
2210 2220 2230
VLKFPDDQTQ KILEREDARL MFTSPRSGIF
Length:2,230
Mass (Da):261,140
Last modified:November 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3BB733DB1EA86134
GO
Isoform 3 (identifier: Q13439-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     2103-2109: Missing.

Show »
Length:2,223
Mass (Da):260,325
Checksum:iB401B4C93E612E70
GO
Isoform 4 (identifier: Q13439-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     2222-2230: FTSPRSGIF → SWLRSSS

Show »
Length:2,228
Mass (Da):260,951
Checksum:i9E1B1F1B13A6A218
GO
Isoform 5 (identifier: Q13439-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     54-54: E → ENASTHASKSPDSVNGSEPSIPQ
     2103-2109: Missing.
     2222-2230: FTSPRSGIF → SWLRSSS

Show »
Length:2,243
Mass (Da):262,328
Checksum:iEDD8BCB88E02B9A4
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0Y6I0H0Y6I0_HUMAN
Golgin subfamily A member 4
GOLGA4
2,099Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7EVX2E7EVX2_HUMAN
Golgin subfamily A member 4
GOLGA4
445Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JHJ5C9JHJ5_HUMAN
Golgin subfamily A member 4
GOLGA4
585Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WTW2A0A087WTW2_HUMAN
Golgin subfamily A member 4
GOLGA4
218Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J0Y3C9J0Y3_HUMAN
Golgin subfamily A member 4
GOLGA4
118Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q86W71Q86W71_HUMAN
GOLGA4 protein
GOLGA4
166Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAD92930 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
The sequence CAA58041 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti188R → K in AAC51791 (PubMed:8537393).Curated1
Sequence conflicti220Y → H in AAC51791 (PubMed:8537393).Curated1
Sequence conflicti276T → A in AAC51791 (PubMed:8537393).Curated1
Sequence conflicti584K → E in AAC51791 (PubMed:8537393).Curated1
Sequence conflicti628T → A in AAC51791 (PubMed:8537393).Curated1
Sequence conflicti630K → E in AAC51791 (PubMed:8537393).Curated1
Sequence conflicti682K → N in AAC51791 (PubMed:8537393).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0339751028Q → K. Corresponds to variant dbSNP:rs11718848Ensembl.1
Natural variantiVAR_0339761552N → S. Corresponds to variant dbSNP:rs9840779Ensembl.1
Natural variantiVAR_0492582058R → S. Corresponds to variant dbSNP:rs11924014Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_04481954E → ENASTHASKSPDSVNGSEPS IPQ in isoform 5. 1 Publication1
Alternative sequenceiVSP_0042742103 – 2109Missing in isoform 3 and isoform 5. 1 Publication7
Alternative sequenceiVSP_0042752222 – 2230FTSPRSGIF → SWLRSSS in isoform 4 and isoform 5. 1 Publication9

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U41740 mRNA Translation: AAC50434.1
X82834 mRNA Translation: CAA58041.1 Frameshift.
AC097359 Genomic DNA No translation available.
AB209693 mRNA Translation: BAD92930.1 Different initiation.
U31906 mRNA Translation: AAC51791.1
X76942 mRNA Translation: CAA54261.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS2666.1 [Q13439-1]
CCDS54564.1 [Q13439-5]

NCBI Reference Sequences

More...
RefSeqi
NP_001166184.1, NM_001172713.1 [Q13439-5]
NP_002069.2, NM_002078.4 [Q13439-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000356847; ENSP00000349305; ENSG00000144674 [Q13439-5]
ENST00000361924; ENSP00000354486; ENSG00000144674 [Q13439-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
2803

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:2803

UCSC genome browser

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UCSCi
uc003cgv.4 human [Q13439-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U41740 mRNA Translation: AAC50434.1
X82834 mRNA Translation: CAA58041.1 Frameshift.
AC097359 Genomic DNA No translation available.
AB209693 mRNA Translation: BAD92930.1 Different initiation.
U31906 mRNA Translation: AAC51791.1
X76942 mRNA Translation: CAA54261.1
CCDSiCCDS2666.1 [Q13439-1]
CCDS54564.1 [Q13439-5]
RefSeqiNP_001166184.1, NM_001172713.1 [Q13439-5]
NP_002069.2, NM_002078.4 [Q13439-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1R4AX-ray2.30E/F/G/H2172-2222[»]
1UPTX-ray1.70B/D/F/H2170-2228[»]
SMRiQ13439
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi109065, 50 interactors
IntActiQ13439, 46 interactors
MINTiQ13439
STRINGi9606.ENSP00000349305

PTM databases

GlyConnecti690
iPTMnetiQ13439
MetOSiteiQ13439
PhosphoSitePlusiQ13439
UniCarbKBiQ13439

Polymorphism and mutation databases

BioMutaiGOLGA4
DMDMi12643718

Proteomic databases

EPDiQ13439
jPOSTiQ13439
MassIVEiQ13439
MaxQBiQ13439
PaxDbiQ13439
PeptideAtlasiQ13439
PRIDEiQ13439
ProteomicsDBi30188
59436 [Q13439-1]
59437 [Q13439-3]
59438 [Q13439-4]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
28305 85 antibodies

Genome annotation databases

EnsembliENST00000356847; ENSP00000349305; ENSG00000144674 [Q13439-5]
ENST00000361924; ENSP00000354486; ENSG00000144674 [Q13439-1]
GeneIDi2803
KEGGihsa:2803
UCSCiuc003cgv.4 human [Q13439-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
2803
DisGeNETi2803

GeneCards: human genes, protein and diseases

More...
GeneCardsi
GOLGA4
HGNCiHGNC:4427 GOLGA4
HPAiENSG00000144674 Low tissue specificity
MIMi602509 gene
neXtProtiNX_Q13439
OpenTargetsiENSG00000144674
PharmGKBiPA28808

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IEA5 Eukaryota
ENOG410XQQG LUCA
GeneTreeiENSGT00730000111139
HOGENOMiCLU_001994_0_0_1
InParanoidiQ13439
KOiK20283
OMAiDEFRNQG
OrthoDBi663248at2759
PhylomeDBiQ13439
TreeFamiTF325082

Enzyme and pathway databases

ReactomeiR-HSA-6811440 Retrograde transport at the Trans-Golgi-Network

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
GOLGA4 human
EvolutionaryTraceiQ13439

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
GOLGA4

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
2803
PharosiQ13439 Tbio

Protein Ontology

More...
PROi
PR:Q13439
RNActiQ13439 protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000144674 Expressed in biceps brachii and 239 other tissues
ExpressionAtlasiQ13439 baseline and differential
GenevisibleiQ13439 HS

Family and domain databases

InterProiView protein in InterPro
IPR000237 GRIP_dom
PfamiView protein in Pfam
PF01465 GRIP, 1 hit
SMARTiView protein in SMART
SM00755 Grip, 1 hit
PROSITEiView protein in PROSITE
PS50913 GRIP, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGOGA4_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q13439
Secondary accession number(s): F8W8Q7
, Q13270, Q13654, Q14436, Q59EW8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1996
Last modified: April 22, 2020
This is version 190 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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