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Protein

Protein OS-9

Gene

OS9

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Lectin which functions in endoplasmic reticulum (ER) quality control and ER-associated degradation (ERAD). May bind terminally misfolded non-glycosylated proteins as well as improperly folded glycoproteins, retain them in the ER, and possibly transfer them to the ubiquitination machinery and promote their degradation. Possible targets include TRPV4.6 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei130Carbohydrate1
Binding sitei182Carbohydrate1
Binding sitei188Carbohydrate1
Binding sitei212Carbohydrate1
Binding sitei218Carbohydrate1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandLectin

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-382556 ABC-family proteins mediated transport
R-HSA-5358346 Hedgehog ligand biogenesis
R-HSA-5362768 Hh mutants that don't undergo autocatalytic processing are degraded by ERAD
R-HSA-5678895 Defective CFTR causes cystic fibrosis
R-HSA-901032 ER Quality Control Compartment (ERQC)

Protein family/group databases

Transport Classification Database

More...
TCDBi
8.A.67.1.1 the os-9 quality control (erad) protein (os-9) family

UniLectin database of carbohydrate-binding proteins

More...
UniLectini
Q13438

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein OS-9
Alternative name(s):
Amplified in osteosarcoma 9
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:OS9
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000135506.15

Human Gene Nomenclature Database

More...
HGNCi
HGNC:16994 OS9

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
609677 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q13438

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi188R → A: Loss of glycan-binding activity and partial inhibition of ERAD of the misfolded glycoprotein NHK (PubMed:19346256). Reduced interaction with SEL1L (PubMed:18264092) not confirmed in (PubMed:19346256). 3 Publications1

Organism-specific databases

DisGeNET

More...
DisGeNETi
10956

Open Targets

More...
OpenTargetsi
ENSG00000135506

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA164724245

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
OS9

Domain mapping of disease mutations (DMDM)

More...
DMDMi
3024310

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 25Sequence analysisAdd BLAST25
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000002195126 – 667Protein OS-9Add BLAST642

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi110 ↔ 123
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi177N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi181 ↔ 216
Disulfide bondi196 ↔ 228

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Intramolecular disulfide bonds.
Isoform 1 and isoform 2 are N-glycosylated.3 Publications

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q13438

MaxQB - The MaxQuant DataBase

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MaxQBi
Q13438

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q13438

PeptideAtlas

More...
PeptideAtlasi
Q13438

PRoteomics IDEntifications database

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PRIDEi
Q13438

ProteomicsDB human proteome resource

More...
ProteomicsDBi
59432
59433 [Q13438-2]
59434 [Q13438-3]
59435 [Q13438-4]

PTM databases

GlyConnect protein glycosylation platform

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GlyConnecti
1666

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q13438

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q13438

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitously expressed. Found as well in all tumor cell lines analyzed, amplified in sarcomas. Highly expressed in osteosarcoma SJSA-1 and rhabdomyosarcoma Rh30 cell lines. Isoform 2 is the major isoform detected in all cell types examined.

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Up-regulated in response to endoplasmic reticulum stress (at protein level).2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000135506 Expressed in 239 organ(s), highest expression level in tendon

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q13438 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q13438 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB011518
HPA013694

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts (via C-terminus) with CPNE6 (via second C2 domain); this interaction occurs in a calcium-dependent manner in vitro (By similarity). Probably part of the HRD1 ubiquitin ligase complex composed at least of SYVN1/HRD1 and SEL1L with which it interacts directly (PubMed:18502753, PubMed:18264092, PubMed:19084021). Through this complex it may interact with ERLEC1 and HSPA5 (PubMed:18502753). Interacts with DERL2 (PubMed:19084021). Interacts with HSP90B1 (PubMed:18264092). Interacts with CREB3 (PubMed:20546900). Interacts with SYVN1 (PubMed:18264092).By similarity4 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
116156, 137 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
Q13438

Database of interacting proteins

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DIPi
DIP-37493N

Protein interaction database and analysis system

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IntActi
Q13438, 36 interactors

Molecular INTeraction database

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MINTi
Q13438

STRING: functional protein association networks

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STRINGi
9606.ENSP00000318165

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1667
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q13438

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q13438

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q13438

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini108 – 178PRKCSHAdd BLAST71

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi414 – 429Asp/Glu-rich (acidic)Add BLAST16

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the OS-9 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG3394 Eukaryota
ENOG410XR8A LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00530000063603

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000293348

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG000974

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q13438

KEGG Orthology (KO)

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KOi
K10088

Identification of Orthologs from Complete Genome Data

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OMAi
HGGPNQD

Database of Orthologous Groups

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OrthoDBi
EOG091G02WQ

Database for complete collections of gene phylogenies

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PhylomeDBi
Q13438

TreeFam database of animal gene trees

More...
TreeFami
TF314309

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
2.70.130.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR009011 Man6P_isomerase_rcpt-bd_dom_sf
IPR012913 OS9-like

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07915 PRKCSH, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (8+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 8 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 8 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q13438-1) [UniParc]FASTAAdd to basket
Also known as: OS-9-1

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAAETLLSSL LGLLLLGLLL PASLTGGVGS LNLEELSEMR YGIEILPLPV
60 70 80 90 100
MGGQSQSSDV VIVSSKYKQR YECRLPAGAI HFQREREEET PAYQGPGIPE
110 120 130 140 150
LLSPMRDAPC LLKTKDWWTY EFCYGRHIQQ YHMEDSEIKG EVLYLGYYQS
160 170 180 190 200
AFDWDDETAK ASKQHRLKRY HSQTYGNGSK CDLNGRPREA EVRFLCDEGA
210 220 230 240 250
GISGDYIDRV DEPLSCSYVL TIRTPRLCPH PLLRPPPSAA PQAILCHPSL
260 270 280 290 300
QPEEYMAYVQ RQADSKQYGD KIIEELQDLG PQVWSETKSG VAPQKMAGAS
310 320 330 340 350
PTKDDSKDSD FWKMLNEPED QAPGGEEVPA EEQDPSPEAA DSASGAPNDF
360 370 380 390 400
QNNVQVKVIR SPADLIRFIE ELKGGTKKGK PNIGQEQPVD DAAEVPQREP
410 420 430 440 450
EKERGDPERQ REMEEEEDED EDEDEDEDER QLLGEFEKEL EGILLPSDRD
460 470 480 490 500
RLRSEVKAGM ERELENIIQE TEKELDPDGL KKESERDRAM LALTSTLNKL
510 520 530 540 550
IKRLEEKQSP ELVKKHKKKR VVPKKPPPSP QPTEEDPEHR VRVRVTKLRL
560 570 580 590 600
GGPNQDLTVL EMKRENPQLK QIEGLVKELL EREGLTAAGK IEIKIVRPWA
610 620 630 640 650
EGTEEGARWL TDEDTRNLKE IFFNILVPGA EEAQKERQRQ KELESNYRRV
660
WGSPGGEGTG DLDEFDF
Note: Major isoform.
Length:667
Mass (Da):75,562
Last modified:November 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i65BA3F66CEC58756
GO
Isoform 2 (identifier: Q13438-2) [UniParc]FASTAAdd to basket
Also known as: OS-9-2

The sequence of this isoform differs from the canonical sequence as follows:
     534-588: Missing.

Note: Major isoform.
Show »
Length:612
Mass (Da):69,246
Checksum:i1FD06F7B23101015
GO
Isoform 3 (identifier: Q13438-3) [UniParc]FASTAAdd to basket
Also known as: OS-9-3

The sequence of this isoform differs from the canonical sequence as follows:
     456-470: Missing.
     534-588: Missing.

Show »
Length:597
Mass (Da):67,505
Checksum:i7D00C1EA449B3DA1
GO
Isoform 4 (identifier: Q13438-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     456-470: Missing.

Note: No experimental confirmation available.
Show »
Length:652
Mass (Da):73,821
Checksum:i7D44F2347B609055
GO
Isoform 5 (identifier: Q13438-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     161-193: Missing.
     263-263: A → AV
     534-588: Missing.

Note: No experimental confirmation available.
Show »
Length:580
Mass (Da):65,520
Checksum:iBE4EEA80CF8EA076
GO
Isoform 6 (identifier: Q13438-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     142-193: Missing.
     534-588: Missing.

Note: No experimental confirmation available.
Show »
Length:560
Mass (Da):63,155
Checksum:iEBF3F8A812BDAF60
GO
Isoform 7 (identifier: Q13438-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     263-263: A → AV
     534-588: Missing.

Note: Gene prediction based on EST data.
Show »
Length:613
Mass (Da):69,346
Checksum:i353DE17278AB9546
GO
Isoform 8 (identifier: Q13438-8) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     55-113: Missing.
     456-470: Missing.
     534-588: Missing.

Note: No experimental confirmation available.
Show »
Length:538
Mass (Da):60,847
Checksum:i30188F4A2A67AD8E
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B4E321B4E321_HUMAN
Protein OS-9
OS9
406Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8W1V2F8W1V2_HUMAN
Protein OS-9
OS9
186Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8W1N0F8W1N0_HUMAN
Protein OS-9
OS9
146Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8VZI7F8VZI7_HUMAN
Protein OS-9
OS9
162Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8W0R2F8W0R2_HUMAN
Protein OS-9
OS9
125Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8VWQ2F8VWQ2_HUMAN
Protein OS-9
OS9
75Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti7L → V in CAG33072 (Ref. 5) Curated1
Sequence conflicti194F → V in BAG64798 (PubMed:14702039).Curated1
Sequence conflicti371E → G in BAG56939 (PubMed:14702039).Curated1
Sequence conflicti497L → F in BAG64798 (PubMed:14702039).Curated1
Sequence conflicti522V → I in BAG60733 (PubMed:14702039).Curated1
Sequence conflicti653S → P in BAG56939 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_069062305D → N1 PublicationCorresponds to variant dbSNP:rs141986192Ensembl.1
Natural variantiVAR_011897398R → W. Corresponds to variant dbSNP:rs1804598Ensembl.1
Natural variantiVAR_034364454S → L. Corresponds to variant dbSNP:rs34764811Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_04677055 – 113Missing in isoform 8. 1 PublicationAdd BLAST59
Alternative sequenceiVSP_046001142 – 193Missing in isoform 6. 1 PublicationAdd BLAST52
Alternative sequenceiVSP_044701161 – 193Missing in isoform 5. 1 PublicationAdd BLAST33
Alternative sequenceiVSP_044702263A → AV in isoform 5 and isoform 7. 1 Publication1
Alternative sequenceiVSP_004352456 – 470Missing in isoform 3, isoform 4 and isoform 8. 1 PublicationAdd BLAST15
Alternative sequenceiVSP_004353534 – 588Missing in isoform 2, isoform 3, isoform 5, isoform 6, isoform 7 and isoform 8. 3 PublicationsAdd BLAST55

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U41635 mRNA Translation: AAB06495.1
AB002805 Genomic DNA Translation: BAA24362.1
AB002806 mRNA Translation: BAA24363.1
AK291374 mRNA Translation: BAF84063.1
AK293435 mRNA Translation: BAG56939.1
AK296770 mRNA Translation: BAG59349.1
AK298532 mRNA Translation: BAG60733.1
AK303858 mRNA Translation: BAG64798.1
CR456791 mRNA Translation: CAG33072.1
AC025165 Genomic DNA No translation available.
CH471054 Genomic DNA Translation: EAW97045.1
CH471054 Genomic DNA Translation: EAW97046.1
CH471054 Genomic DNA Translation: EAW97047.1
BC000532 mRNA Translation: AAH00532.1
BC007254 mRNA Translation: AAH07254.1
BC023513 mRNA Translation: AAH23513.2
U81031 Genomic DNA Translation: AAC39523.2

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS31843.1 [Q13438-1]
CCDS31844.1 [Q13438-2]
CCDS31845.1 [Q13438-4]
CCDS31846.1 [Q13438-3]
CCDS58246.1 [Q13438-6]
CCDS58247.1 [Q13438-7]
CCDS58248.1 [Q13438-5]
CCDS58249.1 [Q13438-8]

Protein sequence database of the Protein Information Resource

More...
PIRi
JC5889

NCBI Reference Sequences

More...
RefSeqi
NP_001017956.1, NM_001017956.2 [Q13438-2]
NP_001017957.1, NM_001017957.2 [Q13438-3]
NP_001017958.1, NM_001017958.2 [Q13438-4]
NP_001248349.1, NM_001261420.1 [Q13438-7]
NP_001248350.1, NM_001261421.1 [Q13438-5]
NP_001248351.1, NM_001261422.1 [Q13438-6]
NP_001248352.1, NM_001261423.1 [Q13438-8]
NP_006803.1, NM_006812.3 [Q13438-1]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.527861

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000257966; ENSP00000257966; ENSG00000135506 [Q13438-7]
ENST00000315970; ENSP00000318165; ENSG00000135506 [Q13438-1]
ENST00000389142; ENSP00000373794; ENSG00000135506 [Q13438-3]
ENST00000389146; ENSP00000373798; ENSG00000135506 [Q13438-4]
ENST00000435406; ENSP00000389632; ENSG00000135506 [Q13438-6]
ENST00000439210; ENSP00000407360; ENSG00000135506 [Q13438-8]
ENST00000551035; ENSP00000447866; ENSG00000135506 [Q13438-5]
ENST00000552285; ENSP00000450010; ENSG00000135506 [Q13438-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
10956

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:10956

UCSC genome browser

More...
UCSCi
uc001spj.4 human [Q13438-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U41635 mRNA Translation: AAB06495.1
AB002805 Genomic DNA Translation: BAA24362.1
AB002806 mRNA Translation: BAA24363.1
AK291374 mRNA Translation: BAF84063.1
AK293435 mRNA Translation: BAG56939.1
AK296770 mRNA Translation: BAG59349.1
AK298532 mRNA Translation: BAG60733.1
AK303858 mRNA Translation: BAG64798.1
CR456791 mRNA Translation: CAG33072.1
AC025165 Genomic DNA No translation available.
CH471054 Genomic DNA Translation: EAW97045.1
CH471054 Genomic DNA Translation: EAW97046.1
CH471054 Genomic DNA Translation: EAW97047.1
BC000532 mRNA Translation: AAH00532.1
BC007254 mRNA Translation: AAH07254.1
BC023513 mRNA Translation: AAH23513.2
U81031 Genomic DNA Translation: AAC39523.2
CCDSiCCDS31843.1 [Q13438-1]
CCDS31844.1 [Q13438-2]
CCDS31845.1 [Q13438-4]
CCDS31846.1 [Q13438-3]
CCDS58246.1 [Q13438-6]
CCDS58247.1 [Q13438-7]
CCDS58248.1 [Q13438-5]
CCDS58249.1 [Q13438-8]
PIRiJC5889
RefSeqiNP_001017956.1, NM_001017956.2 [Q13438-2]
NP_001017957.1, NM_001017957.2 [Q13438-3]
NP_001017958.1, NM_001017958.2 [Q13438-4]
NP_001248349.1, NM_001261420.1 [Q13438-7]
NP_001248350.1, NM_001261421.1 [Q13438-5]
NP_001248351.1, NM_001261422.1 [Q13438-6]
NP_001248352.1, NM_001261423.1 [Q13438-8]
NP_006803.1, NM_006812.3 [Q13438-1]
UniGeneiHs.527861

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3AIHX-ray2.10A/B108-229[»]
ProteinModelPortaliQ13438
SMRiQ13438
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116156, 137 interactors
CORUMiQ13438
DIPiDIP-37493N
IntActiQ13438, 36 interactors
MINTiQ13438
STRINGi9606.ENSP00000318165

Protein family/group databases

TCDBi8.A.67.1.1 the os-9 quality control (erad) protein (os-9) family
UniLectiniQ13438

PTM databases

GlyConnecti1666
iPTMnetiQ13438
PhosphoSitePlusiQ13438

Polymorphism and mutation databases

BioMutaiOS9
DMDMi3024310

Proteomic databases

EPDiQ13438
MaxQBiQ13438
PaxDbiQ13438
PeptideAtlasiQ13438
PRIDEiQ13438
ProteomicsDBi59432
59433 [Q13438-2]
59434 [Q13438-3]
59435 [Q13438-4]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
10956
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000257966; ENSP00000257966; ENSG00000135506 [Q13438-7]
ENST00000315970; ENSP00000318165; ENSG00000135506 [Q13438-1]
ENST00000389142; ENSP00000373794; ENSG00000135506 [Q13438-3]
ENST00000389146; ENSP00000373798; ENSG00000135506 [Q13438-4]
ENST00000435406; ENSP00000389632; ENSG00000135506 [Q13438-6]
ENST00000439210; ENSP00000407360; ENSG00000135506 [Q13438-8]
ENST00000551035; ENSP00000447866; ENSG00000135506 [Q13438-5]
ENST00000552285; ENSP00000450010; ENSG00000135506 [Q13438-2]
GeneIDi10956
KEGGihsa:10956
UCSCiuc001spj.4 human [Q13438-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
10956
DisGeNETi10956
EuPathDBiHostDB:ENSG00000135506.15

GeneCards: human genes, protein and diseases

More...
GeneCardsi
OS9
HGNCiHGNC:16994 OS9
HPAiCAB011518
HPA013694
MIMi609677 gene
neXtProtiNX_Q13438
OpenTargetsiENSG00000135506
PharmGKBiPA164724245

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3394 Eukaryota
ENOG410XR8A LUCA
GeneTreeiENSGT00530000063603
HOGENOMiHOG000293348
HOVERGENiHBG000974
InParanoidiQ13438
KOiK10088
OMAiHGGPNQD
OrthoDBiEOG091G02WQ
PhylomeDBiQ13438
TreeFamiTF314309

Enzyme and pathway databases

ReactomeiR-HSA-382556 ABC-family proteins mediated transport
R-HSA-5358346 Hedgehog ligand biogenesis
R-HSA-5362768 Hh mutants that don't undergo autocatalytic processing are degraded by ERAD
R-HSA-5678895 Defective CFTR causes cystic fibrosis
R-HSA-901032 ER Quality Control Compartment (ERQC)

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
OS9 human
EvolutionaryTraceiQ13438

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
OS9_(gene)

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
10956

Protein Ontology

More...
PROi
PR:Q13438

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000135506 Expressed in 239 organ(s), highest expression level in tendon
ExpressionAtlasiQ13438 baseline and differential
GenevisibleiQ13438 HS

Family and domain databases

Gene3Di2.70.130.10, 1 hit
InterProiView protein in InterPro
IPR009011 Man6P_isomerase_rcpt-bd_dom_sf
IPR012913 OS9-like
PfamiView protein in Pfam
PF07915 PRKCSH, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiOS9_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q13438
Secondary accession number(s): A6NDD1
, A6NFR7, A6NLB2, A8K5Q9, B4DE28, B4DPX1, B4E1I6, E7ENT8, E7EW91, F8VUH2, G3XA88, O00579, Q6IBL2, Q8IZ58, Q9BW99
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: November 7, 2018
This is version 165 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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