Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
We will be switching to the new UniProt website soon. Please explore and share your feedback. Take me to the new website.

UniProtKB - Q13427 (PPIG_HUMAN)

Entry version 189 (23 Feb 2022)
Sequence version 2 (05 May 2009)
Previous versions | rss
Add a publicationFeedback
Protein

Peptidyl-prolyl cis-trans isomerase G

Gene

PPIG

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding (PubMed:20676357).

May be implicated in the folding, transport, and assembly of proteins. May play an important role in the regulation of pre-mRNA splicing.

1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Inhibited by cyclosporin A (CsA).1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionIsomerase, Rotamase

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...BRENDAi		5.2.1.8, 2681

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q13427

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q13427

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Peptidyl-prolyl cis-trans isomerase G (EC:5.2.1.81 Publication)
Short name:
PPIase G
Short name:
Peptidyl-prolyl isomerase G
Alternative name(s):
CASP10
Clk-associating RS-cyclophilin
Short name:
CARS-Cyp
Short name:
CARS-cyclophilin
Short name:
SR-cyclophilin
Short name:
SR-cyp
Short name:
SRcyp
Cyclophilin G
Rotamase G
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PPIG
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:14650, PPIG

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		606093, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q13427

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000138398

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		9360

Open Targets

More...OpenTargetsi		ENSG00000138398

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA33585

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q13427, Tchem

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL3707467

Drug and drug target database

More...DrugBanki		DB00172, Proline

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		PPIG

Domain mapping of disease mutations (DMDM)

More...DMDMi		229462749

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000641501 – 754Peptidyl-prolyl cis-trans isomerase GAdd BLAST754

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei254PhosphoserineCombined sources1
Modified residuei256PhosphoserineCombined sources1
Modified residuei257PhosphoserineCombined sources1
Modified residuei259PhosphoserineCombined sources1
Modified residuei290PhosphoserineCombined sources1
Modified residuei315PhosphoserineCombined sources1
Modified residuei356PhosphoserineCombined sources1
Modified residuei358PhosphothreonineCombined sources1
Modified residuei386PhosphoserineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki392Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei397PhosphoserineCombined sources1
Modified residuei413PhosphoserineCombined sources1
Modified residuei415PhosphoserineCombined sources1
Modified residuei687PhosphoserineCombined sources1
Modified residuei690PhosphoserineCombined sources1
Cross-linki693Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei696PhosphoserineCombined sources1
Modified residuei744PhosphoserineCombined sources1
Modified residuei745PhosphoserineCombined sources1
Modified residuei748PhosphothreonineCombined sources1
Modified residuei753PhosphoserineCombined sources1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q13427

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q13427

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q13427

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q13427

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q13427

PeptideAtlas

More...PeptideAtlasi		Q13427

PRoteomics IDEntifications database

More...PRIDEi		Q13427

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		59415 [Q13427-1]
59416 [Q13427-2]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q13427, 1 site, 1 O-linked glycan (1 site)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q13427

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q13427

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitous.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000138398, Expressed in sural nerve and 257 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q13427, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q13427, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000138398, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with CLK1, PNN and with the phosphorylated C-terminal domain of RNA polymerase II.

2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		114761, 101 interactors

Protein interaction database and analysis system

More...IntActi		Q13427, 51 interactors

Molecular INTeraction database

More...MINTi		Q13427

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000260970

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		Q13427

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q13427, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1754
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q13427

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		Q13427

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini11 – 176PPIase cyclophilin-typePROSITE-ProRule annotationAdd BLAST166

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni182 – 754DisorderedSequence analysisAdd BLAST573

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi195 – 218Polar residuesSequence analysisAdd BLAST24
Compositional biasi228 – 252Basic residuesSequence analysisAdd BLAST25
Compositional biasi288 – 311Basic and acidic residuesSequence analysisAdd BLAST24
Compositional biasi327 – 349Basic residuesSequence analysisAdd BLAST23
Compositional biasi350 – 368Basic and acidic residuesSequence analysisAdd BLAST19
Compositional biasi375 – 450Basic and acidic residuesSequence analysisAdd BLAST76
Compositional biasi465 – 566Basic and acidic residuesSequence analysisAdd BLAST102
Compositional biasi567 – 581Basic residuesSequence analysisAdd BLAST15
Compositional biasi582 – 602Basic and acidic residuesSequence analysisAdd BLAST21
Compositional biasi625 – 688Basic and acidic residuesSequence analysisAdd BLAST64
Compositional biasi703 – 754Basic and acidic residuesSequence analysisAdd BLAST52

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The RS domain is required for the interaction with the phosphorylated C-terminal domain of RNA polymerase II.1 Publication

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0546, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000157954

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_012062_33_6_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q13427

Identification of Orthologs from Complete Genome Data

More...OMAi		YDHYERS

Database of Orthologous Groups

More...OrthoDBi		1403619at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q13427

TreeFam database of animal gene trees

More...TreeFami		TF318563

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.40.100.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR029000, Cyclophilin-like_dom_sf
IPR020892, Cyclophilin-type_PPIase_CS
IPR002130, Cyclophilin-type_PPIase_dom

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00160, Pro_isomerase, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00153, CSAPPISMRASE

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF50891, SSF50891, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00170, CSA_PPIASE_1, 1 hit
PS50072, CSA_PPIASE_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 9 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q13427-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGIKVQRPRC FFDIAINNQP AGRVVFELFS DVCPKTCENF RCLCTGEKGT 
        60         70         80         90        100
GKSTQKPLHY KSCLFHRVVK DFMVQGGDFS EGNGRGGESI YGGFFEDESF 
       110        120        130        140        150
AVKHNKEFLL SMANRGKDTN GSQFFITTKP TPHLDGHHVV FGQVISGQEV 
       160        170        180        190        200
VREIENQKTD AASKPFAEVR ILSCGELIPK SKVKKEEKKR HKSSSSSSSS 
       210        220        230        240        250
SSDSDSSSDS QSSSDSSDSE SATEEKSKKR KKKHRKNSRK HKKEKKKRKK 
       260        270        280        290        300
SKKSASSESE AENLEAQPQS TVRPEEIPPI PENRFLMRKS PPKADEKERK 
       310        320        330        340        350
NREREREREC NPPNSQPASY QRRLLVTRSG RKIKGRGPRR YRTPSRSRSR 
       360        370        380        390        400
DRFRRSETPP HWRQEMQRAQ RMRVSSGERW IKGDKSELNE IKENQRSPVR 
       410        420        430        440        450
VKERKITDHR NVSESPNRKN EKEKKVKDHK SNSKERDIRR NSEKDDKYKN 
       460        470        480        490        500
KVKKRAKSKS RSKSKEKSKS KERDSKHNRN EEKRMRSRSK GRDHENVKEK 
       510        520        530        540        550
EKQSDSKGKD QERSRSKEKS KQLESKSNEH DHSKSKEKDR RAQSRSRECD 
       560        570        580        590        600
ITKGKHSYNS RTRERSRSRD RSRRVRSRTH DRDRSRSKEY HRYREQEYRR 
       610        620        630        640        650
RGRSRSRERR TPPGRSRSKD RRRRRRDSRS SEREESQSRN KDKYRNQESK 
       660        670        680        690        700
SSHRKENSES EKRMYSKSRD HNSSNNSREK KADRDQSPFS KIKQSSQDNE 
       710        720        730        740        750
LKSSMLKNKE DEKIRSSVEK ENQKSKGQEN DHVHEKNKKF DHESSPGTDE 

DKSG
Length:754
Mass (Da):88,617
Last modified:May 5, 2009 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD4884808D8060CD6
GO
Isoform 2 (identifier: Q13427-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     340-357: RYRTPSRSRSRDRFRRSE → VGDSFPRDLHNIAFVFLK
     358-754: Missing.

Show »
Length:357
Mass (Da):40,299
Checksum:i506BC6E24E1ADD4B
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JN15C9JN15_HUMAN
Peptidyl-prolyl cis-trans isomerase
PPIG
246Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A7I2V4W3A0A7I2V4W3_HUMAN
Peptidyl-prolyl cis-trans isomerase
PPIG
133Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PG73E9PG73_HUMAN
Peptidyl-prolyl cis-trans isomerase...
PPIG
739Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JM79C9JM79_HUMAN
Peptidyl-prolyl cis-trans isomerase...
PPIG
487Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A7I2V5Q5A0A7I2V5Q5_HUMAN
Peptidyl-prolyl cis-trans isomerase...
PPIG
751Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A7I2V629A0A7I2V629_HUMAN
Peptidyl-prolyl cis-trans isomerase...
PPIG
732Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A7I2V4F2A0A7I2V4F2_HUMAN
Peptidyl-prolyl cis-trans isomerase...
PPIG
679Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A7I2V2U3A0A7I2V2U3_HUMAN
Peptidyl-prolyl cis-trans isomerase...
PPIG
65Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J679C9J679_HUMAN
Peptidyl-prolyl cis-trans isomerase...
PPIG
104Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_055084445D → E. Corresponds to variant dbSNP:rs1050354Ensembl.1
Natural variantiVAR_055085699N → DCombined sources2 PublicationsCorresponds to variant dbSNP:rs8207Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_009662340 – 357RYRTP…FRRSE → VGDSFPRDLHNIAFVFLK in isoform 2. 1 PublicationAdd BLAST18
Alternative sequenceiVSP_009663358 – 754Missing in isoform 2. 1 PublicationAdd BLAST397

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
U40763 mRNA Translation: AAB40347.1
X99717 mRNA Translation: CAA68053.1
AC093899 Genomic DNA Translation: AAY24119.1
AC016772 Genomic DNA Translation: AAY24233.1
CH471058 Genomic DNA Translation: EAX11267.1
CH471058 Genomic DNA Translation: EAX11268.1
CH471058 Genomic DNA Translation: EAX11269.1
CH471058 Genomic DNA Translation: EAX11270.1
BC001555 mRNA Translation: AAH01555.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS2235.1 [Q13427-1]

Protein sequence database of the Protein Information Resource

More...PIRi		JC5314

NCBI Reference Sequences

More...RefSeqi		NP_004783.2, NM_004792.2 [Q13427-1]
XP_005247023.1, XM_005246966.1 [Q13427-1]
XP_005247024.1, XM_005246967.1 [Q13427-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000260970; ENSP00000260970; ENSG00000138398
ENST00000414307; ENSP00000402222; ENSG00000138398 [Q13427-2]
ENST00000433207; ENSP00000408683; ENSG00000138398
ENST00000448752; ENSP00000407083; ENSG00000138398
ENST00000462903; ENSP00000435987; ENSG00000138398 [Q13427-2]
ENST00000676756; ENSP00000503525; ENSG00000138398
ENST00000678499; ENSP00000503136; ENSG00000138398
ENST00000679107; ENSP00000502997; ENSG00000138398

Database of genes from NCBI RefSeq genomes

More...GeneIDi		9360

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:9360

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000260970.8; ENSP00000260970.3; NM_004792.3; NP_004783.2

UCSC genome browser

More...UCSCi		uc002uez.4, human [Q13427-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U40763 mRNA Translation: AAB40347.1
X99717 mRNA Translation: CAA68053.1
AC093899 Genomic DNA Translation: AAY24119.1
AC016772 Genomic DNA Translation: AAY24233.1
CH471058 Genomic DNA Translation: EAX11267.1
CH471058 Genomic DNA Translation: EAX11268.1
CH471058 Genomic DNA Translation: EAX11269.1
CH471058 Genomic DNA Translation: EAX11270.1
BC001555 mRNA Translation: AAH01555.1
CCDSiCCDS2235.1 [Q13427-1]
PIRiJC5314
RefSeqiNP_004783.2, NM_004792.2 [Q13427-1]
XP_005247023.1, XM_005246966.1 [Q13427-1]
XP_005247024.1, XM_005246967.1 [Q13427-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2GW2X-ray1.80A1-179[»]
2WFIX-ray0.75A1-177[»]
2WFJX-ray0.75A1-177[»]
5YZGelectron microscopy4.1031-754[»]
SMRiQ13427
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi114761, 101 interactors
IntActiQ13427, 51 interactors
MINTiQ13427
STRINGi9606.ENSP00000260970

Chemistry databases

BindingDBiQ13427
ChEMBLiCHEMBL3707467
DrugBankiDB00172, Proline

PTM databases

GlyGeniQ13427, 1 site, 1 O-linked glycan (1 site)
iPTMnetiQ13427
PhosphoSitePlusiQ13427

Genetic variation databases

BioMutaiPPIG
DMDMi229462749

Proteomic databases

EPDiQ13427
jPOSTiQ13427
MassIVEiQ13427
MaxQBiQ13427
PaxDbiQ13427
PeptideAtlasiQ13427
PRIDEiQ13427
ProteomicsDBi59415 [Q13427-1]
59416 [Q13427-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		19292, 275 antibodies from 34 providers

The DNASU plasmid repository

More...DNASUi		9360

Genome annotation databases

EnsembliENST00000260970; ENSP00000260970; ENSG00000138398
ENST00000414307; ENSP00000402222; ENSG00000138398 [Q13427-2]
ENST00000433207; ENSP00000408683; ENSG00000138398
ENST00000448752; ENSP00000407083; ENSG00000138398
ENST00000462903; ENSP00000435987; ENSG00000138398 [Q13427-2]
ENST00000676756; ENSP00000503525; ENSG00000138398
ENST00000678499; ENSP00000503136; ENSG00000138398
ENST00000679107; ENSP00000502997; ENSG00000138398
GeneIDi9360
KEGGihsa:9360
MANE-SelectiENST00000260970.8; ENSP00000260970.3; NM_004792.3; NP_004783.2
UCSCiuc002uez.4, human [Q13427-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		9360
DisGeNETi9360

GeneCards: human genes, protein and diseases

More...GeneCardsi		PPIG
HGNCiHGNC:14650, PPIG
HPAiENSG00000138398, Low tissue specificity
MIMi606093, gene
neXtProtiNX_Q13427
OpenTargetsiENSG00000138398
PharmGKBiPA33585
VEuPathDBiHostDB:ENSG00000138398

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0546, Eukaryota
GeneTreeiENSGT00940000157954
HOGENOMiCLU_012062_33_6_1
InParanoidiQ13427
OMAiYDHYERS
OrthoDBi1403619at2759
PhylomeDBiQ13427
TreeFamiTF318563

Enzyme and pathway databases

BRENDAi5.2.1.8, 2681
PathwayCommonsiQ13427
SignaLinkiQ13427

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		9360, 11 hits in 1049 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		PPIG, human
EvolutionaryTraceiQ13427

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		PPIG_(gene)

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		9360
PharosiQ13427, Tchem

Protein Ontology

More...PROi		PR:Q13427
RNActiQ13427, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000138398, Expressed in sural nerve and 257 other tissues
ExpressionAtlasiQ13427, baseline and differential
GenevisibleiQ13427, HS

Family and domain databases

Gene3Di2.40.100.10, 1 hit
InterProiView protein in InterPro
IPR029000, Cyclophilin-like_dom_sf
IPR020892, Cyclophilin-type_PPIase_CS
IPR002130, Cyclophilin-type_PPIase_dom
PfamiView protein in Pfam
PF00160, Pro_isomerase, 1 hit
PRINTSiPR00153, CSAPPISMRASE
SUPFAMiSSF50891, SSF50891, 1 hit
PROSITEiView protein in PROSITE
PS00170, CSA_PPIASE_1, 1 hit
PS50072, CSA_PPIASE_2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPPIG_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q13427
Secondary accession number(s): D3DPC5
, D3DPC6, O00706, Q53R40, Q53SN4, Q96DG9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2004
Last sequence update: May 5, 2009
Last modified: February 23, 2022
This is version 189 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again