UniProtKB - Q13425 (SNTB2_HUMAN)
Beta-2-syntrophin
SNTB2
Functioni
GO - Molecular functioni
- actin binding Source: UniProtKB-KW
- calmodulin binding Source: UniProtKB-KW
- RNA binding Source: UniProtKB
- structural molecule activity Source: InterPro
Keywordsi
Molecular function | Actin-binding, Calmodulin-binding |
Ligand | Calcium |
Enzyme and pathway databases
PathwayCommonsi | Q13425 |
SIGNORi | Q13425 |
Names & Taxonomyi
Protein namesi | Recommended name: Beta-2-syntrophinAlternative name(s): 59 kDa dystrophin-associated protein A1 basic component 2 Syntrophin-3 Short name: SNT3 Syntrophin-like Short name: SNTL |
Gene namesi | Name:SNTB2 Synonyms:D16S2531E, SNT2B2, SNTL |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:11169, SNTB2 |
MIMi | 600027, gene |
neXtProti | NX_Q13425 |
VEuPathDBi | HostDB:ENSG00000168807.16 |
Subcellular locationi
Cytoskeleton
Other locations
- Membrane
- secretory vesicle membrane ; Peripheral membrane protein
- Cell junction By similarity
Note: Membrane-associated. In muscle, it is exclusively localized at the neuromuscular junction (By similarity). In insulinoma cell line, it is enriched in secretory granules.By similarity
Cytoskeleton
- microtubule Source: UniProtKB-KW
Golgi apparatus
- Golgi apparatus Source: HPA
Nucleus
- nucleoplasm Source: HPA
Plasma Membrane
- dystrophin-associated glycoprotein complex Source: GO_Central
- plasma membrane Source: HPA
Other locations
- cytoplasm Source: UniProtKB
- focal adhesion Source: UniProtKB
- membrane Source: ProtInc
- protein-containing complex Source: MGI
- synapse Source: GO_Central
- transport vesicle membrane Source: UniProtKB-SubCell
Keywords - Cellular componenti
Cell junction, Cytoplasm, Cytoplasmic vesicle, Cytoskeleton, Membrane, MicrotubulePathology & Biotechi
Organism-specific databases
DisGeNETi | 6645 |
OpenTargetsi | ENSG00000168807 |
PharmGKBi | PA36009 |
Miscellaneous databases
Pharosi | Q13425, Tbio |
Genetic variation databases
BioMutai | SNTB2 |
DMDMi | 23822158 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000184011 | 1 – 540 | Beta-2-syntrophinAdd BLAST | 540 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 95 | PhosphoserineCombined sources | 1 | |
Modified residuei | 110 | PhosphoserineCombined sources | 1 | |
Modified residuei | 129 | PhosphoserineCombined sources | 1 | |
Modified residuei | 211 | PhosphoserineCombined sources | 1 | |
Modified residuei | 222 | PhosphoserineCombined sources | 1 | |
Modified residuei | 233 | PhosphoserineCombined sources | 1 | |
Modified residuei | 393 | PhosphoserineCombined sources | 1 | |
Modified residuei | 395 | PhosphoserineCombined sources | 1 |
Post-translational modificationi
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q13425 |
jPOSTi | Q13425 |
MassIVEi | Q13425 |
MaxQBi | Q13425 |
PaxDbi | Q13425 |
PeptideAtlasi | Q13425 |
PRIDEi | Q13425 |
ProteomicsDBi | 59410 [Q13425-1] 59411 [Q13425-2] |
PTM databases
iPTMneti | Q13425 |
PhosphoSitePlusi | Q13425 |
SwissPalmi | Q13425 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000168807, Expressed in adipose tissue and 240 other tissues |
ExpressionAtlasi | Q13425, baseline and differential |
Genevisiblei | Q13425, HS |
Organism-specific databases
HPAi | ENSG00000168807, Low tissue specificity |
Interactioni
Subunit structurei
Monomer and homodimer (Probable).
Interacts with the other members of the syntrophin family: SNTA1 and SNTB1; and with the sodium channel proteins SCN4A and SCN5A.
Interacts with SAST, MAST205, microtubules and microtubule-associated proteins (By similarity).
Interacts with the dystrophin protein DMD and related proteins DTNA and UTRN, and with the neuroregulin receptor ERBB4.
Interacts with PTPRN when phosphorylated, protecting PTPRN from protein cleavage by CAPN1. Dephosphorylation upon insulin stimulation disrupts the interaction with PTPRN and results in the cleavage of PTPRN.
By similarityCurated4 PublicationsBinary interactionsi
Hide detailsQ13425
With | #Exp. | IntAct |
---|---|---|
ADRA1D [P25100] | 16 | EBI-80411,EBI-489993 |
CASK [O14936] | 2 | EBI-80411,EBI-1215506 |
DMD [P11532] | 2 | EBI-80411,EBI-295827 |
GO - Molecular functioni
- actin binding Source: UniProtKB-KW
- calmodulin binding Source: UniProtKB-KW
Protein-protein interaction databases
BioGRIDi | 112528, 69 interactors |
IntActi | Q13425, 51 interactors |
MINTi | Q13425 |
STRINGi | 9606.ENSP00000338191 |
Miscellaneous databases
RNActi | Q13425, protein |
Structurei
Secondary structure
3D structure databases
SMRi | Q13425 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q13425 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 115 – 198 | PDZPROSITE-ProRule annotationAdd BLAST | 84 | |
Domaini | 163 – 300 | PH 1PROSITE-ProRule annotationAdd BLAST | 138 | |
Domaini | 325 – 437 | PH 2PROSITE-ProRule annotationAdd BLAST | 113 | |
Domaini | 484 – 540 | SUAdd BLAST | 57 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 518 – 540 | Calmodulin-bindingBy similarityAdd BLAST | 23 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 54 – 57 | Poly-Ala | 4 | |
Compositional biasi | 66 – 69 | Poly-Ala | 4 |
Domaini
Sequence similaritiesi
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | KOG3551, Eukaryota |
GeneTreei | ENSGT00950000182863 |
HOGENOMi | CLU_026406_3_1_1 |
InParanoidi | Q13425 |
OMAi | WRPILMA |
PhylomeDBi | Q13425 |
TreeFami | TF317932 |
Family and domain databases
CDDi | cd01258, PHsplit_syntrophin, 1 hit |
Gene3Di | 2.30.29.30, 1 hit 2.30.42.10, 1 hit |
InterProi | View protein in InterPro IPR001478, PDZ IPR036034, PDZ_sf IPR011993, PH-like_dom_sf IPR001849, PH_domain IPR041428, PHsplit_syntrophin IPR028550, SNTB2 IPR015482, Syntrophin |
PANTHERi | PTHR10554, PTHR10554, 1 hit PTHR10554:SF8, PTHR10554:SF8, 1 hit |
Pfami | View protein in Pfam PF00595, PDZ, 1 hit PF18012, PH_17, 1 hit |
SMARTi | View protein in SMART SM00228, PDZ, 1 hit SM00233, PH, 2 hits |
SUPFAMi | SSF50156, SSF50156, 1 hit |
PROSITEi | View protein in PROSITE PS50106, PDZ, 1 hit PS50003, PH_DOMAIN, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MRVAAATAAA GAGPAMAVWT RATKAGLVEL LLRERWVRVV AELSGESLSL
60 70 80 90 100
TGDAAAAELE PALGPAAAAF NGLPNGGGAG DSLPGSPSRG LGPPSPPAPP
110 120 130 140 150
RGPAGEAGAS PPVRRVRVVK QEAGGLGISI KGGRENRMPI LISKIFPGLA
160 170 180 190 200
ADQSRALRLG DAILSVNGTD LRQATHDQAV QALKRAGKEV LLEVKFIREV
210 220 230 240 250
TPYIKKPSLV SDLPWEGAAP QSPSFSGSED SGSPKHQNST KDRKIIPLKM
260 270 280 290 300
CFAARNLSMP DLENRLIELH SPDSRNTLIL RCKDTATAHS WFVAIHTNIM
310 320 330 340 350
ALLPQVLAEL NAMLGATSTA GGSKEVKHIA WLAEQAKLDG GRQQWRPVLM
360 370 380 390 400
AVTEKDLLLY DCMPWTRDAW ASPCHSYPLV ATRLVHSGSG CRSPSLGSDL
410 420 430 440 450
TFATRTGSRQ GIEMHLFRVE THRDLSSWTR ILVQGCHAAA ELIKEVSLGC
460 470 480 490 500
MLNGQEVRLT IHYENGFTIS RENGGSSSIL YRYPFERLKM SADDGIRNLY
510 520 530 540
LDFGGPEGEL TMDLHSCPKP IVFVLHTFLS AKVTRMGLLV
The sequence of this isoform differs from the canonical sequence as follows:
266-267: LI → QN
268-540: Missing.
Computationally mapped potential isoform sequencesi
There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketH0YCS0 | H0YCS0_HUMAN | Beta-2-syntrophin | SNTB2 | 162 | Annotation score: | ||
A0A140TA73 | A0A140TA73_HUMAN | Beta-2-syntrophin | SNTB2 | 193 | Annotation score: | ||
J3KT21 | J3KT21_HUMAN | Beta-2-syntrophin | SNTB2 | 64 | Annotation score: | ||
A0A0G2JM75 | A0A0G2JM75_HUMAN | Beta-2-syntrophin | SNTB2 | 62 | Annotation score: | ||
H7BY41 | H7BY41_HUMAN | Beta-2-syntrophin | SNTB2 | 139 | Annotation score: | ||
A0A0G2JLB8 | A0A0G2JLB8_HUMAN | Beta-2-syntrophin | SNTB2 | 50 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_073697 | 376 | S → R1 Publication | 1 | |
Natural variantiVAR_014076 | 424 | D → E. Corresponds to variant dbSNP:rs1058482Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_006358 | 266 – 267 | LI → QN in isoform 2. 1 Publication | 2 | |
Alternative sequenceiVSP_006359 | 268 – 540 | Missing in isoform 2. 1 PublicationAdd BLAST | 273 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U40572 mRNA Translation: AAC50449.1 AF243385 mRNA Translation: AAK15149.1 BC048215 mRNA Translation: AAH48215.1 |
CCDSi | CCDS10873.1 [Q13425-1] |
RefSeqi | NP_006741.1, NM_006750.3 [Q13425-1] |
Genome annotation databases
Ensembli | ENST00000336278; ENSP00000338191; ENSG00000168807 [Q13425-1] ENST00000467311; ENSP00000436443; ENSG00000168807 [Q13425-2] |
GeneIDi | 6645 |
KEGGi | hsa:6645 |
UCSCi | uc002ewu.4, human [Q13425-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U40572 mRNA Translation: AAC50449.1 AF243385 mRNA Translation: AAK15149.1 BC048215 mRNA Translation: AAH48215.1 |
CCDSi | CCDS10873.1 [Q13425-1] |
RefSeqi | NP_006741.1, NM_006750.3 [Q13425-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2VRF | X-ray | 2.00 | A/B/C/D | 112-200 | [»] | |
SMRi | Q13425 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 112528, 69 interactors |
IntActi | Q13425, 51 interactors |
MINTi | Q13425 |
STRINGi | 9606.ENSP00000338191 |
PTM databases
iPTMneti | Q13425 |
PhosphoSitePlusi | Q13425 |
SwissPalmi | Q13425 |
Genetic variation databases
BioMutai | SNTB2 |
DMDMi | 23822158 |
Proteomic databases
EPDi | Q13425 |
jPOSTi | Q13425 |
MassIVEi | Q13425 |
MaxQBi | Q13425 |
PaxDbi | Q13425 |
PeptideAtlasi | Q13425 |
PRIDEi | Q13425 |
ProteomicsDBi | 59410 [Q13425-1] 59411 [Q13425-2] |
Protocols and materials databases
Antibodypediai | 656, 151 antibodies |
DNASUi | 6645 |
Genome annotation databases
Ensembli | ENST00000336278; ENSP00000338191; ENSG00000168807 [Q13425-1] ENST00000467311; ENSP00000436443; ENSG00000168807 [Q13425-2] |
GeneIDi | 6645 |
KEGGi | hsa:6645 |
UCSCi | uc002ewu.4, human [Q13425-1] |
Organism-specific databases
CTDi | 6645 |
DisGeNETi | 6645 |
GeneCardsi | SNTB2 |
HGNCi | HGNC:11169, SNTB2 |
HPAi | ENSG00000168807, Low tissue specificity |
MIMi | 600027, gene |
neXtProti | NX_Q13425 |
OpenTargetsi | ENSG00000168807 |
PharmGKBi | PA36009 |
VEuPathDBi | HostDB:ENSG00000168807.16 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3551, Eukaryota |
GeneTreei | ENSGT00950000182863 |
HOGENOMi | CLU_026406_3_1_1 |
InParanoidi | Q13425 |
OMAi | WRPILMA |
PhylomeDBi | Q13425 |
TreeFami | TF317932 |
Enzyme and pathway databases
PathwayCommonsi | Q13425 |
SIGNORi | Q13425 |
Miscellaneous databases
BioGRID-ORCSi | 6645, 6 hits in 990 CRISPR screens |
ChiTaRSi | SNTB2, human |
EvolutionaryTracei | Q13425 |
GeneWikii | SNTB2 |
GenomeRNAii | 6645 |
Pharosi | Q13425, Tbio |
PROi | PR:Q13425 |
RNActi | Q13425, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000168807, Expressed in adipose tissue and 240 other tissues |
ExpressionAtlasi | Q13425, baseline and differential |
Genevisiblei | Q13425, HS |
Family and domain databases
CDDi | cd01258, PHsplit_syntrophin, 1 hit |
Gene3Di | 2.30.29.30, 1 hit 2.30.42.10, 1 hit |
InterProi | View protein in InterPro IPR001478, PDZ IPR036034, PDZ_sf IPR011993, PH-like_dom_sf IPR001849, PH_domain IPR041428, PHsplit_syntrophin IPR028550, SNTB2 IPR015482, Syntrophin |
PANTHERi | PTHR10554, PTHR10554, 1 hit PTHR10554:SF8, PTHR10554:SF8, 1 hit |
Pfami | View protein in Pfam PF00595, PDZ, 1 hit PF18012, PH_17, 1 hit |
SMARTi | View protein in SMART SM00228, PDZ, 1 hit SM00233, PH, 2 hits |
SUPFAMi | SSF50156, SSF50156, 1 hit |
PROSITEi | View protein in PROSITE PS50106, PDZ, 1 hit PS50003, PH_DOMAIN, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | SNTB2_HUMAN | |
Accessioni | Q13425Primary (citable) accession number: Q13425 Secondary accession number(s): Q9BY09 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 10, 2002 |
Last sequence update: | November 1, 1996 | |
Last modified: | April 7, 2021 | |
This is version 206 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 16
Human chromosome 16: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families