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Protein

Beta-2-syntrophin

Gene

SNTB2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Adapter protein that binds to and probably organizes the subcellular localization of a variety of membrane proteins. May link various receptors to the actin cytoskeleton and the dystrophin glycoprotein complex. May play a role in the regulation of secretory granules via its interaction with PTPRN.

GO - Molecular functioni

Keywordsi

Molecular functionActin-binding, Calmodulin-binding
LigandCalcium

Enzyme and pathway databases

SIGNORiQ13425

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-2-syntrophin
Alternative name(s):
59 kDa dystrophin-associated protein A1 basic component 2
Syntrophin-3
Short name:
SNT3
Syntrophin-like
Short name:
SNTL
Gene namesi
Name:SNTB2
Synonyms:D16S2531E, SNT2B2, SNTL
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000168807.16
HGNCiHGNC:11169 SNTB2
MIMi600027 gene
neXtProtiNX_Q13425

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cytoplasm, Cytoplasmic vesicle, Cytoskeleton, Membrane, Microtubule

Pathology & Biotechi

Organism-specific databases

DisGeNETi6645
OpenTargetsiENSG00000168807
PharmGKBiPA36009

Polymorphism and mutation databases

BioMutaiSNTB2
DMDMi23822158

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001840111 – 540Beta-2-syntrophinAdd BLAST540

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei95PhosphoserineCombined sources1
Modified residuei110PhosphoserineCombined sources1
Modified residuei129PhosphoserineCombined sources1
Modified residuei211PhosphoserineCombined sources1
Modified residuei222PhosphoserineCombined sources1
Modified residuei233PhosphoserineCombined sources1
Modified residuei393PhosphoserineCombined sources1
Modified residuei395PhosphoserineCombined sources1

Post-translational modificationi

Phosphorylated. Partially dephosphorylated upon insulin stimulation.

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ13425
MaxQBiQ13425
PaxDbiQ13425
PeptideAtlasiQ13425
PRIDEiQ13425
ProteomicsDBi59410
59411 [Q13425-2]

PTM databases

iPTMnetiQ13425
PhosphoSitePlusiQ13425
SwissPalmiQ13425

Expressioni

Tissue specificityi

Ubiquitous. Isoform 1 is the predominant isoform. Weak level of isoform 2 is present in all tested tissues, except in liver and heart where it is highly expressed.

Gene expression databases

BgeeiENSG00000168807 Expressed in 226 organ(s), highest expression level in adipose tissue
CleanExiHS_SNTB2
ExpressionAtlasiQ13425 baseline and differential
GenevisibleiQ13425 HS

Interactioni

Subunit structurei

Monomer and homodimer (Probable). Interacts with the other members of the syntrophin family: SNTA1 and SNTB1; and with the sodium channel proteins SCN4A and SCN5A. Interacts with SAST, MAST205, microtubules and microtubule-associated proteins (By similarity). Interacts with the dystrophin protein DMD and related proteins DTNA and UTRN, and with the neuroregulin receptor ERBB4. Interacts with PTPRN when phosphorylated, protecting PTPRN from protein cleavage by CAPN1. Dephosphorylation upon insulin stimulation disrupts the interaction with PTPRN and results in the cleavage of PTPRN.By similarityCurated4 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
CASKO149362EBI-80411,EBI-1215506

GO - Molecular functioni

Protein-protein interaction databases

BioGridi112528, 46 interactors
IntActiQ13425, 25 interactors
MINTiQ13425
STRINGi9606.ENSP00000338191

Structurei

Secondary structure

1540
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ13425
SMRiQ13425
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ13425

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini115 – 198PDZPROSITE-ProRule annotationAdd BLAST84
Domaini163 – 300PH 1PROSITE-ProRule annotationAdd BLAST138
Domaini325 – 437PH 2PROSITE-ProRule annotationAdd BLAST113
Domaini484 – 540SUAdd BLAST57

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni518 – 540Calmodulin-bindingBy similarityAdd BLAST23

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi54 – 57Poly-Ala4
Compositional biasi66 – 69Poly-Ala4

Domaini

The PH 1 domain mediates the oligomerization in a calcium dependent manner.By similarity
The PDZ domain binds to the last three or four amino acids of ion channels and receptor proteins. The association with dystrophin or related proteins probably leaves the PDZ domain available to recruit proteins to the membrane (By similarity).By similarity
The SU domain binds calmodulin in a calcium-dependent manner.By similarity

Sequence similaritiesi

Belongs to the syntrophin family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IMRK Eukaryota
ENOG4111J6R LUCA
GeneTreeiENSGT00550000074581
HOGENOMiHOG000231596
HOVERGENiHBG054204
InParanoidiQ13425
OMAiFRVETHW
OrthoDBiEOG091G0O31
PhylomeDBiQ13425
TreeFamiTF317932

Family and domain databases

Gene3Di2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR001478 PDZ
IPR036034 PDZ_sf
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR028550 SNTB2
IPR015482 Syntrophin
PANTHERiPTHR10554 PTHR10554, 1 hit
PTHR10554:SF8 PTHR10554:SF8, 1 hit
PfamiView protein in Pfam
PF00595 PDZ, 1 hit
SMARTiView protein in SMART
SM00228 PDZ, 1 hit
SM00233 PH, 2 hits
SUPFAMiSSF50156 SSF50156, 1 hit
PROSITEiView protein in PROSITE
PS50106 PDZ, 1 hit
PS50003 PH_DOMAIN, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q13425-1) [UniParc]FASTAAdd to basket
Also known as: Beta2-syntrophin58

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRVAAATAAA GAGPAMAVWT RATKAGLVEL LLRERWVRVV AELSGESLSL
60 70 80 90 100
TGDAAAAELE PALGPAAAAF NGLPNGGGAG DSLPGSPSRG LGPPSPPAPP
110 120 130 140 150
RGPAGEAGAS PPVRRVRVVK QEAGGLGISI KGGRENRMPI LISKIFPGLA
160 170 180 190 200
ADQSRALRLG DAILSVNGTD LRQATHDQAV QALKRAGKEV LLEVKFIREV
210 220 230 240 250
TPYIKKPSLV SDLPWEGAAP QSPSFSGSED SGSPKHQNST KDRKIIPLKM
260 270 280 290 300
CFAARNLSMP DLENRLIELH SPDSRNTLIL RCKDTATAHS WFVAIHTNIM
310 320 330 340 350
ALLPQVLAEL NAMLGATSTA GGSKEVKHIA WLAEQAKLDG GRQQWRPVLM
360 370 380 390 400
AVTEKDLLLY DCMPWTRDAW ASPCHSYPLV ATRLVHSGSG CRSPSLGSDL
410 420 430 440 450
TFATRTGSRQ GIEMHLFRVE THRDLSSWTR ILVQGCHAAA ELIKEVSLGC
460 470 480 490 500
MLNGQEVRLT IHYENGFTIS RENGGSSSIL YRYPFERLKM SADDGIRNLY
510 520 530 540
LDFGGPEGEL TMDLHSCPKP IVFVLHTFLS AKVTRMGLLV
Length:540
Mass (Da):57,950
Last modified:November 1, 1996 - v1
Checksum:i53A9F3340DC024ED
GO
Isoform 2 (identifier: Q13425-2) [UniParc]FASTAAdd to basket
Also known as: Beta2-syntrophin28

The sequence of this isoform differs from the canonical sequence as follows:
     266-267: LI → QN
     268-540: Missing.

Note: Lacks domains required for interaction with dystrophin related proteins. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:267
Mass (Da):27,677
Checksum:i45DF36C82C013228
GO

Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YCS0H0YCS0_HUMAN
Beta-2-syntrophin
SNTB2
162Annotation score:
J3KT21J3KT21_HUMAN
Beta-2-syntrophin
SNTB2
64Annotation score:
H7BY41H7BY41_HUMAN
Beta-2-syntrophin
SNTB2
139Annotation score:
A0A140TA73A0A140TA73_HUMAN
Beta-2-syntrophin
SNTB2
193Annotation score:
A0A0G2JM75A0A0G2JM75_HUMAN
Beta-2-syntrophin
SNTB2
62Annotation score:
A0A0G2JLB8A0A0G2JLB8_HUMAN
Beta-2-syntrophin
SNTB2
50Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_073697376S → R1 Publication1
Natural variantiVAR_014076424D → E. Corresponds to variant dbSNP:rs1058482Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_006358266 – 267LI → QN in isoform 2. 1 Publication2
Alternative sequenceiVSP_006359268 – 540Missing in isoform 2. 1 PublicationAdd BLAST273

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U40572 mRNA Translation: AAC50449.1
AF243385 mRNA Translation: AAK15149.1
BC048215 mRNA Translation: AAH48215.1
CCDSiCCDS10873.1 [Q13425-1]
RefSeqiNP_006741.1, NM_006750.3 [Q13425-1]
UniGeneiHs.461117

Genome annotation databases

EnsembliENST00000336278; ENSP00000338191; ENSG00000168807 [Q13425-1]
ENST00000467311; ENSP00000436443; ENSG00000168807 [Q13425-2]
ENST00000562438; ENSP00000458999; ENSG00000260873
GeneIDi6645
KEGGihsa:6645
UCSCiuc002ewu.4 human [Q13425-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U40572 mRNA Translation: AAC50449.1
AF243385 mRNA Translation: AAK15149.1
BC048215 mRNA Translation: AAH48215.1
CCDSiCCDS10873.1 [Q13425-1]
RefSeqiNP_006741.1, NM_006750.3 [Q13425-1]
UniGeneiHs.461117

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2VRFX-ray2.00A/B/C/D112-200[»]
ProteinModelPortaliQ13425
SMRiQ13425
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112528, 46 interactors
IntActiQ13425, 25 interactors
MINTiQ13425
STRINGi9606.ENSP00000338191

PTM databases

iPTMnetiQ13425
PhosphoSitePlusiQ13425
SwissPalmiQ13425

Polymorphism and mutation databases

BioMutaiSNTB2
DMDMi23822158

Proteomic databases

EPDiQ13425
MaxQBiQ13425
PaxDbiQ13425
PeptideAtlasiQ13425
PRIDEiQ13425
ProteomicsDBi59410
59411 [Q13425-2]

Protocols and materials databases

DNASUi6645
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000336278; ENSP00000338191; ENSG00000168807 [Q13425-1]
ENST00000467311; ENSP00000436443; ENSG00000168807 [Q13425-2]
ENST00000562438; ENSP00000458999; ENSG00000260873
GeneIDi6645
KEGGihsa:6645
UCSCiuc002ewu.4 human [Q13425-1]

Organism-specific databases

CTDi6645
DisGeNETi6645
EuPathDBiHostDB:ENSG00000168807.16
GeneCardsiSNTB2
HGNCiHGNC:11169 SNTB2
MIMi600027 gene
neXtProtiNX_Q13425
OpenTargetsiENSG00000168807
PharmGKBiPA36009
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IMRK Eukaryota
ENOG4111J6R LUCA
GeneTreeiENSGT00550000074581
HOGENOMiHOG000231596
HOVERGENiHBG054204
InParanoidiQ13425
OMAiFRVETHW
OrthoDBiEOG091G0O31
PhylomeDBiQ13425
TreeFamiTF317932

Enzyme and pathway databases

SIGNORiQ13425

Miscellaneous databases

ChiTaRSiSNTB2 human
EvolutionaryTraceiQ13425
GeneWikiiSNTB2
GenomeRNAii6645
PROiPR:Q13425
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000168807 Expressed in 226 organ(s), highest expression level in adipose tissue
CleanExiHS_SNTB2
ExpressionAtlasiQ13425 baseline and differential
GenevisibleiQ13425 HS

Family and domain databases

Gene3Di2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR001478 PDZ
IPR036034 PDZ_sf
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR028550 SNTB2
IPR015482 Syntrophin
PANTHERiPTHR10554 PTHR10554, 1 hit
PTHR10554:SF8 PTHR10554:SF8, 1 hit
PfamiView protein in Pfam
PF00595 PDZ, 1 hit
SMARTiView protein in SMART
SM00228 PDZ, 1 hit
SM00233 PH, 2 hits
SUPFAMiSSF50156 SSF50156, 1 hit
PROSITEiView protein in PROSITE
PS50106 PDZ, 1 hit
PS50003 PH_DOMAIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSNTB2_HUMAN
AccessioniPrimary (citable) accession number: Q13425
Secondary accession number(s): Q9BY09
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2002
Last sequence update: November 1, 1996
Last modified: November 7, 2018
This is version 187 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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Main funding by: National Institutes of Health

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