UniProtKB - Q13425 (SNTB2_HUMAN)

BLAST

>sp|Q13425|SNTB2_HUMAN Beta-2-syntrophin OS=Homo sapiens OX=9606 GN=SNTB2 PE=1 SV=1
MRVAAATAAAGAGPAMAVWTRATKAGLVELLLRERWVRVVAELSGESLSLTGDAAAAELE
PALGPAAAAFNGLPNGGGAGDSLPGSPSRGLGPPSPPAPPRGPAGEAGASPPVRRVRVVK
QEAGGLGISIKGGRENRMPILISKIFPGLAADQSRALRLGDAILSVNGTDLRQATHDQAV
QALKRAGKEVLLEVKFIREVTPYIKKPSLVSDLPWEGAAPQSPSFSGSEDSGSPKHQNST
KDRKIIPLKMCFAARNLSMPDLENRLIELHSPDSRNTLILRCKDTATAHSWFVAIHTNIM
ALLPQVLAELNAMLGATSTAGGSKEVKHIAWLAEQAKLDGGRQQWRPVLMAVTEKDLLLY
DCMPWTRDAWASPCHSYPLVATRLVHSGSGCRSPSLGSDLTFATRTGSRQGIEMHLFRVE
THRDLSSWTRILVQGCHAAAELIKEVSLGCMLNGQEVRLTIHYENGFTISRENGGSSSIL
YRYPFERLKMSADDGIRNLYLDFGGPEGELTMDLHSCPKPIVFVLHTFLSAKVTRMGLLV

Align

Format
Add to basket Added to basket
History
Entry version 187 (07 Nov 2018)
Sequence version 1 (01 Nov 1996)
Previous versions | rss
Other tutorials and videos
Help video
Feedback

Protein

Beta-2-syntrophin

Gene

SNTB2

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Adapter protein that binds to and probably organizes the subcellular localization of a variety of membrane proteins. May link various receptors to the actin cytoskeleton and the dystrophin glycoprotein complex. May play a role in the regulation of secretory granules via its interaction with PTPRN.

GO - Molecular functionⁱ

actin binding Source: UniProtKB-KW
calmodulin binding Source: UniProtKB-KW
RNA binding
Source: UniProtKB
Inferred from high throughput direct assayⁱ
- 22658674
structural molecule activity Source: InterPro

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Actin-binding, Calmodulin-binding
Ligand	Calcium

Enzyme and pathway databases

SIGNORⁱ	Q13425

SIGNORⁱ

Q13425

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Beta-2-syntrophin Alternative name(s): 59 kDa dystrophin-associated protein A1 basic component 2 Syntrophin-3 Short name: SNT3 Syntrophin-like Short name: SNTL
Gene namesⁱ	Name:SNTB2 Synonyms:D16S2531E, SNT2B2, SNTL
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 16

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000168807.16
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:11169 SNTB2
MIMⁱ	600027 gene
neXtProtⁱ	NX_Q13425

Keywords - Cellular componentⁱ

Cell junction, Cytoplasm, Cytoplasmic vesicle, Cytoskeleton, Membrane, Microtubule

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	6645
Open Targets More...OpenTargetsⁱ	ENSG00000168807
PharmGKBⁱ	PA36009

Polymorphism and mutation databases

BioMutaⁱ	SNTB2
DMDMⁱ	23822158

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000184011	1 – 540	Beta-2-syntrophinAdd BLAST		540

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	95	PhosphoserineCombined sources	1
Modified residueⁱ	110	PhosphoserineCombined sources	1
Modified residueⁱ	129	PhosphoserineCombined sources	1
Modified residueⁱ	211	PhosphoserineCombined sources	1
Modified residueⁱ	222	PhosphoserineCombined sources	1
Modified residueⁱ	233	PhosphoserineCombined sources	1
Modified residueⁱ	393	PhosphoserineCombined sources	1
Modified residueⁱ	395	PhosphoserineCombined sources	1

Post-translational modificationⁱ

Phosphorylated. Partially dephosphorylated upon insulin stimulation.

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	Q13425
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q13425
PaxDbⁱ	Q13425
PeptideAtlas More...PeptideAtlasⁱ	Q13425
PRIDEⁱ	Q13425
ProteomicsDBⁱ	59410 59411 [Q13425-2]

PTM databases

iPTMnetⁱ	Q13425
PhosphoSitePlusⁱ	Q13425
SwissPalmⁱ	Q13425

Expressionⁱ

Tissue specificityⁱ

Ubiquitous. Isoform 1 is the predominant isoform. Weak level of isoform 2 is present in all tested tissues, except in liver and heart where it is highly expressed.

Gene expression databases

Bgeeⁱ	ENSG00000168807 Expressed in 226 organ(s), highest expression level in adipose tissue
CleanExⁱ	HS_SNTB2
ExpressionAtlasⁱ	Q13425 baseline and differential
Genevisibleⁱ	Q13425 HS

Interactionⁱ

Subunit structureⁱ

Monomer and homodimer (Probable). Interacts with the other members of the syntrophin family: SNTA1 and SNTB1; and with the sodium channel proteins SCN4A and SCN5A. Interacts with SAST, MAST205, microtubules and microtubule-associated proteins (By similarity). Interacts with the dystrophin protein DMD and related proteins DTNA and UTRN, and with the neuroregulin receptor ERBB4. Interacts with PTPRN when phosphorylated, protecting PTPRN from protein cleavage by CAPN1. Dephosphorylation upon insulin stimulation disrupts the interaction with PTPRN and results in the cleavage of PTPRN.By similarityCurated4 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
CASK	O14936	2	EBI-80411,EBI-1215506

With

Entry

#Exp.

IntAct

Notes

CASK

O14936

EBI-80411,EBI-1215506

GO - Molecular functionⁱ

actin binding Source: UniProtKB-KW
calmodulin binding Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	112528, 46 interactors
IntActⁱ	Q13425, 25 interactors
Molecular INTeraction database More...MINTⁱ	Q13425
STRINGⁱ	9606.ENSP00000338191

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	113 – 119	Combined sources	7
Beta strandⁱ	127 – 133	Combined sources	7
Helixⁱ	134 – 136	Combined sources	3
Beta strandⁱ	138 – 145	Combined sources	8
Helixⁱ	150 – 154	Combined sources	5
Beta strandⁱ	161 – 166	Combined sources	6
Helixⁱ	176 – 184	Combined sources	9
Beta strandⁱ	188 – 196	Combined sources	9

Show more details

3D structure databases

ProteinModelPortalⁱ	Q13425
SMRⁱ	Q13425
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	Q13425

EvolutionaryTraceⁱ

Q13425

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	115 – 198	PDZPROSITE-ProRule annotationAdd BLAST	84
Domainⁱ	163 – 300	PH 1PROSITE-ProRule annotationAdd BLAST	138
Domainⁱ	325 – 437	PH 2PROSITE-ProRule annotationAdd BLAST	113
Domainⁱ	484 – 540	SUAdd BLAST	57

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	518 – 540	Calmodulin-bindingBy similarityAdd BLAST		23

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	54 – 57	Poly-Ala		4
Compositional biasⁱ	66 – 69	Poly-Ala		4

Domainⁱ

The PH 1 domain mediates the oligomerization in a calcium dependent manner.By similarity

The PDZ domain binds to the last three or four amino acids of ion channels and receptor proteins. The association with dystrophin or related proteins probably leaves the PDZ domain available to recruit proteins to the membrane (By similarity).By similarity

The SU domain binds calmodulin in a calcium-dependent manner.By similarity

Sequence similaritiesⁱ

Belongs to the syntrophin family.Curated

Keywords - Domainⁱ

Repeat

Phylogenomic databases

eggNOGⁱ	ENOG410IMRK Eukaryota ENOG4111J6R LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00550000074581
HOGENOMⁱ	HOG000231596
HOVERGENⁱ	HBG054204
InParanoidⁱ	Q13425
OMAⁱ	FRVETHW
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0O31
PhylomeDBⁱ	Q13425
TreeFamⁱ	TF317932

Family and domain databases

Gene3Dⁱ	2.30.29.30, 1 hit
InterProⁱ	View protein in InterPro IPR001478 PDZ IPR036034 PDZ_sf IPR011993 PH-like_dom_sf IPR001849 PH_domain IPR028550 SNTB2 IPR015482 Syntrophin
PANTHERⁱ	PTHR10554 PTHR10554, 1 hit PTHR10554:SF8 PTHR10554:SF8, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00595 PDZ, 1 hit
SMARTⁱ	View protein in SMART SM00228 PDZ, 1 hit SM00233 PH, 2 hits
SUPFAMⁱ	SSF50156 SSF50156, 1 hit
PROSITEⁱ	View protein in PROSITE PS50106 PDZ, 1 hit PS50003 PH_DOMAIN, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 6 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q13425-1) [UniParc]FASTA Add to basket

Also known as: Beta2-syntrophin58

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRVAAATAAA GAGPAMAVWT RATKAGLVEL LLRERWVRVV AELSGESLSL 
        60         70         80         90        100
TGDAAAAELE PALGPAAAAF NGLPNGGGAG DSLPGSPSRG LGPPSPPAPP 
       110        120        130        140        150
RGPAGEAGAS PPVRRVRVVK QEAGGLGISI KGGRENRMPI LISKIFPGLA 
       160        170        180        190        200
ADQSRALRLG DAILSVNGTD LRQATHDQAV QALKRAGKEV LLEVKFIREV 
       210        220        230        240        250
TPYIKKPSLV SDLPWEGAAP QSPSFSGSED SGSPKHQNST KDRKIIPLKM 
       260        270        280        290        300
CFAARNLSMP DLENRLIELH SPDSRNTLIL RCKDTATAHS WFVAIHTNIM 
       310        320        330        340        350
ALLPQVLAEL NAMLGATSTA GGSKEVKHIA WLAEQAKLDG GRQQWRPVLM 
       360        370        380        390        400
AVTEKDLLLY DCMPWTRDAW ASPCHSYPLV ATRLVHSGSG CRSPSLGSDL 
       410        420        430        440        450
TFATRTGSRQ GIEMHLFRVE THRDLSSWTR ILVQGCHAAA ELIKEVSLGC 
       460        470        480        490        500
MLNGQEVRLT IHYENGFTIS RENGGSSSIL YRYPFERLKM SADDGIRNLY 
       510        520        530        540
LDFGGPEGEL TMDLHSCPKP IVFVLHTFLS AKVTRMGLLV

Length:540

Mass (Da):57,950

Last modified:November 1, 1996 - v1

Checksum:ⁱ53A9F3340DC024ED

Isoform 2 (identifier: Q13425-2) [UniParc]FASTA Add to basket

Also known as: Beta2-syntrophin28

The sequence of this isoform differs from the canonical sequence as follows:
266-267: LI → QN
268-540: Missing.

« Hide

        10         20         30         40         50
MRVAAATAAA GAGPAMAVWT RATKAGLVEL LLRERWVRVV AELSGESLSL 
        60         70         80         90        100
TGDAAAAELE PALGPAAAAF NGLPNGGGAG DSLPGSPSRG LGPPSPPAPP 
       110        120        130        140        150
RGPAGEAGAS PPVRRVRVVK QEAGGLGISI KGGRENRMPI LISKIFPGLA 
       160        170        180        190        200
ADQSRALRLG DAILSVNGTD LRQATHDQAV QALKRAGKEV LLEVKFIREV 
       210        220        230        240        250
TPYIKKPSLV SDLPWEGAAP QSPSFSGSED SGSPKHQNST KDRKIIPLKM 
       260 
CFAARNLSMP DLENRQN

Note: Lacks domains required for interaction with dystrophin related proteins. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

Show »

Length:267

Mass (Da):27,677

Checksum:ⁱ45DF36C82C013228

Computationally mapped potential isoform sequencesⁱ

There are 6 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

H0YCS0	H0YCS0_HUMAN	Beta-2-syntrophin Beta-2-syntrophin	SNTB2	162	Annotation score:
J3KT21	J3KT21_HUMAN	Beta-2-syntrophin Beta-2-syntrophin	SNTB2	64	Annotation score:
H7BY41	H7BY41_HUMAN	Beta-2-syntrophin Beta-2-syntrophin	SNTB2	139	Annotation score:
A0A140TA73	A0A140TA73_HUMAN	Beta-2-syntrophin Beta-2-syntrophin	SNTB2	193	Annotation score:
A0A0G2JM75	A0A0G2JM75_HUMAN	Beta-2-syntrophin Beta-2-syntrophin	SNTB2	62	Annotation score:
A0A0G2JLB8	A0A0G2JLB8_HUMAN	Beta-2-syntrophin Beta-2-syntrophin	SNTB2	50	Annotation score:

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_073697	376	S → R1 Publication		1
Natural variantⁱVAR_014076	424	D → E. Corresponds to variant dbSNP:rs1058482Ensembl.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_006358	266 – 267	LI → QN in isoform 2. 1 Publication		2
Alternative sequenceⁱVSP_006359	268 – 540	Missing in isoform 2. 1 PublicationAdd BLAST		273

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U40572 mRNA Translation: AAC50449.1 AF243385 mRNA Translation: AAK15149.1 BC048215 mRNA Translation: AAH48215.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS10873.1 [Q13425-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_006741.1, NM_006750.3 [Q13425-1]
UniGeneⁱ	Hs.461117

Genome annotation databases

Ensemblⁱ	ENST00000336278; ENSP00000338191; ENSG00000168807 [Q13425-1] ENST00000467311; ENSP00000436443; ENSG00000168807 [Q13425-2] ENST00000562438; ENSP00000458999; ENSG00000260873
GeneIDⁱ	6645
KEGGⁱ	hsa:6645
UCSC genome browser More...UCSCⁱ	uc002ewu.4 human [Q13425-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q13425	Syntrophin, beta 2 (Dystrophin-associated protein A1, 59kDa, basic component 2), isoform CRA_a		HUMAN		540	UniRef100_Q13425
Uncharacterized protein		NOMLE		540
Uncharacterized protein		RHIRO		275
Beta-2-syntrophin (Fragment)		HUMAN		193
UPI0002ADA4C4		NOMLE		565

Protein	Similar proteins		Species	Score	Length	Source
Q13425	Beta-2-syntrophin		MOUSE		520	UniRef90_Q13425
Syntrophin, beta 2 (Dystrophin-associated protein A1, 59kDa, basic component 2), isoform CRA_a		HUMAN		540
Uncharacterized protein		NOMLE		540
Uncharacterized protein		RHIRO		275
Syntrophin beta 2		CANLF		568
+77

Protein	Similar proteins		Species	Score	Length	Source
Q13425	Beta-2-syntrophin		MOUSE		520	UniRef50_Q13425
Syntrophin, beta 2 (Dystrophin-associated protein A1, 59kDa, basic component 2), isoform CRA_a		HUMAN		540
Uncharacterized protein		NOMLE		540
Uncharacterized protein		RHIRO		275
Syntrophin beta 2		CANLF		568
+101
Q13425-2	Uncharacterized protein		ONCMY		234	UniRef50_Q13425-2
PDZ domain-containing protein MAGIX		ALLMI		217
UPI000809E31A		Cebus capucinus imitator		224
UPI000DF2413E		PUMCO		224
UPI0009070359		ALLMI		244

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U40572 mRNA Translation: AAC50449.1 AF243385 mRNA Translation: AAK15149.1 BC048215 mRNA Translation: AAH48215.1
CCDSⁱ	CCDS10873.1 [Q13425-1]
RefSeqⁱ	NP_006741.1, NM_006750.3 [Q13425-1]
UniGeneⁱ	Hs.461117

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2VRF	X-ray	2.00	A/B/C/D	112-200	[»]
ProteinModelPortalⁱ	Q13425
SMRⁱ	Q13425
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	112528, 46 interactors
IntActⁱ	Q13425, 25 interactors
MINTⁱ	Q13425
STRINGⁱ	9606.ENSP00000338191

PTM databases

iPTMnetⁱ	Q13425
PhosphoSitePlusⁱ	Q13425
SwissPalmⁱ	Q13425

Polymorphism and mutation databases

BioMutaⁱ	SNTB2
DMDMⁱ	23822158

Proteomic databases

EPDⁱ	Q13425
MaxQBⁱ	Q13425
PaxDbⁱ	Q13425
PeptideAtlasⁱ	Q13425
PRIDEⁱ	Q13425
ProteomicsDBⁱ	59410 59411 [Q13425-2]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	6645
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000336278; ENSP00000338191; ENSG00000168807 [Q13425-1] ENST00000467311; ENSP00000436443; ENSG00000168807 [Q13425-2] ENST00000562438; ENSP00000458999; ENSG00000260873
GeneIDⁱ	6645
KEGGⁱ	hsa:6645
UCSCⁱ	uc002ewu.4 human [Q13425-1]

Organism-specific databases

CTDⁱ	6645
DisGeNETⁱ	6645
EuPathDBⁱ	HostDB:ENSG00000168807.16
GeneCardsⁱ	SNTB2
HGNCⁱ	HGNC:11169 SNTB2
MIMⁱ	600027 gene
neXtProtⁱ	NX_Q13425
OpenTargetsⁱ	ENSG00000168807
PharmGKBⁱ	PA36009
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IMRK Eukaryota ENOG4111J6R LUCA
GeneTreeⁱ	ENSGT00550000074581
HOGENOMⁱ	HOG000231596
HOVERGENⁱ	HBG054204
InParanoidⁱ	Q13425
OMAⁱ	FRVETHW
OrthoDBⁱ	EOG091G0O31
PhylomeDBⁱ	Q13425
TreeFamⁱ	TF317932

Enzyme and pathway databases

SIGNORⁱ	Q13425

SIGNORⁱ

Q13425

Miscellaneous databases

ChiTaRSⁱ	SNTB2 human
EvolutionaryTraceⁱ	Q13425
GeneWikiⁱ	SNTB2
GenomeRNAiⁱ	6645
Protein Ontology More...PROⁱ	PR:Q13425
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000168807 Expressed in 226 organ(s), highest expression level in adipose tissue
CleanExⁱ	HS_SNTB2
ExpressionAtlasⁱ	Q13425 baseline and differential
Genevisibleⁱ	Q13425 HS

Family and domain databases

Gene3Dⁱ	2.30.29.30, 1 hit
InterProⁱ	View protein in InterPro IPR001478 PDZ IPR036034 PDZ_sf IPR011993 PH-like_dom_sf IPR001849 PH_domain IPR028550 SNTB2 IPR015482 Syntrophin
PANTHERⁱ	PTHR10554 PTHR10554, 1 hit PTHR10554:SF8 PTHR10554:SF8, 1 hit
Pfamⁱ	View protein in Pfam PF00595 PDZ, 1 hit
SMARTⁱ	View protein in SMART SM00228 PDZ, 1 hit SM00233 PH, 2 hits
SUPFAMⁱ	SSF50156 SSF50156, 1 hit
PROSITEⁱ	View protein in PROSITE PS50106 PDZ, 1 hit PS50003 PH_DOMAIN, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	SNTB2_HUMAN
Accessionⁱ	Q13425Primary (citable) accession number: Q13425 Secondary accession number(s): Q9BY09
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 10, 2002
	Last sequence update:	November 1, 1996
	Last modified:	November 7, 2018
	This is version 187 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 16
Human chromosome 16: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q13425 (SNTB2_HUMAN)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the ‘basket’ to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

Beta-2-syntrophin

SNTB2

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Cytoskeleton

Other locations

Cytoskeleton

Plasma Membrane

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

Your basket is currently empty. ⁱ

Functionⁱ

GO - Molecular functionⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ