SNTA1

Functionⁱ

Adapter protein that binds to and probably organizes the subcellular localization of a variety of membrane proteins. May link various receptors to the actin cytoskeleton and the extracellular matrix via the dystrophin glycoprotein complex. Plays an important role in synapse formation and in the organization of UTRN and acetylcholine receptors at the neuromuscular synapse. Binds to phosphatidylinositol 4,5-bisphosphate (By similarity).By similarity

GO - Molecular functionⁱ

actin binding Source: UniProtKB-KW
ATPase binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 18591664
calmodulin binding Source: UniProtKB-KW
ion channel binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 18591664
nitric-oxide synthase binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 18591664
PDZ domain binding Source: Ensembl
structural molecule activity Source: InterPro

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

muscle contraction
Source: ProtInc
Traceable author statementⁱ
- 8576247
negative regulation of peptidyl-cysteine S-nitrosylation
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 18591664
regulation of heart rate
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 18591664
regulation of sodium ion transmembrane transport
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 18591664
regulation of ventricular cardiac muscle cell membrane repolarization
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 18591664
ventricular cardiac muscle cell action potential
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 18591664

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Actin-binding, Calmodulin-binding
Ligand	Calcium

Enzyme and pathway databases

SIGNORⁱ	Q13424

SIGNORⁱ

Q13424

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Alpha-1-syntrophin Alternative name(s): 59 kDa dystrophin-associated protein A1 acidic component 1 Pro-TGF-alpha cytoplasmic domain-interacting protein 1 Short name: TACIP1 Syntrophin-1
Gene namesⁱ	Name:SNTA1 Synonyms:SNT1
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 20

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000101400.5
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:11167 SNTA1
MIMⁱ	601017 gene
neXtProtⁱ	NX_Q13424

Keywords - Cellular componentⁱ

Cell junction, Cell membrane, Cytoplasm, Cytoskeleton, Membrane

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Long QT syndrome 12 (LQT12)2 Publications

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA heart disorder characterized by a prolonged QT interval on the ECG and polymorphic ventricular arrhythmias. They cause syncope and sudden death in response to exercise or emotional stress, and can present with a sentinel event of sudden cardiac death in infancy.

Keywords - Diseaseⁱ

Disease mutation, Long QT syndrome

Organism-specific databases

DisGeNET More...DisGeNETⁱ	6640
GeneReviewsⁱ	SNTA1
MalaCards human disease database More...MalaCardsⁱ	SNTA1
MIMⁱ	612955 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000101400
Orphanetⁱ	101016 Romano-Ward syndrome
PharmGKBⁱ	PA36007

Polymorphism and mutation databases

BioMutaⁱ	SNTA1
DMDMⁱ	23822157

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000184006	1 – 505	Alpha-1-syntrophinAdd BLAST		505

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	101	PhosphoserineBy similarity	1
Modified residueⁱ	184	PhosphoserineCombined sources	1
Modified residueⁱ	189	PhosphoserineCombined sources	1
Modified residueⁱ	193	PhosphoserineCombined sources	1
Modified residueⁱ	200	PhosphoserineBy similarity	1

Post-translational modificationⁱ

Phosphorylated by CaM-kinase II. Phosphorylation may inhibit the interaction with DMD (By similarity).By similarity

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	Q13424
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q13424
PaxDbⁱ	Q13424
PeptideAtlas More...PeptideAtlasⁱ	Q13424
PRIDEⁱ	Q13424
ProteomicsDBⁱ	59409

PTM databases

iPTMnetⁱ	Q13424
PhosphoSitePlusⁱ	Q13424

Expressionⁱ

Tissue specificityⁱ

High expression in skeletal muscle and heart. Low expression in brain, pancreas, liver, kidney and lung. Not detected in placenta.

Gene expression databases

Bgeeⁱ	ENSG00000101400 Expressed in 207 organ(s), highest expression level in apex of heart
CleanExⁱ	HS_SNTA1
Genevisibleⁱ	Q13424 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB037059

HPAⁱ

CAB037059

Interactionⁱ

Subunit structureⁱ

Monomer and homodimer. Interacts with the other members of the syntrophin family SNTB1 and SNTB2; SGCG and SGCA of the dystrophin glycoprotein complex; NOS1; GRB2; the sodium channel proteins SCN4A and SCN5A; F-actin and calmodulin (By similarity). Interacts with dystrophin protein DMD and related proteins DTNA and UTRN and with MAPK12, TGFA and GA. Interacts with MYOC; regulates muscle hypertrophy (By similarity).By similarity

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
ABCA1	O95477	2	EBI-717191,EBI-784112
Mapk12	Q63538	5	EBI-717191,EBI-783937	From Rattus norvegicus.

GO - Molecular functionⁱ

actin binding Source: UniProtKB-KW
ATPase binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 18591664
calmodulin binding Source: UniProtKB-KW
ion channel binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 18591664
nitric-oxide synthase binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 18591664
PDZ domain binding Source: Ensembl

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	112523, 84 interactors
Database of interacting proteins More...DIPⁱ	DIP-966N
IntActⁱ	Q13424, 7 interactors
Molecular INTeraction database More...MINTⁱ	Q13424
STRINGⁱ	9606.ENSP00000217381

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q13424
SMRⁱ	Q13424
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	6 – 269	PH 1PROSITE-ProRule annotationAdd BLAST	264
Domainⁱ	87 – 170	PDZPROSITE-ProRule annotationAdd BLAST	84
Domainⁱ	293 – 401	PH 2PROSITE-ProRule annotationAdd BLAST	109
Domainⁱ	449 – 505	SUAdd BLAST	57

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	483 – 505	Calmodulin-bindingBy similarityAdd BLAST		23

Domainⁱ

The PH 1 domain mediates the oligomerization in a calcium dependent manner, and the association with the phosphatidylinositol 4,5-bisphosphate.By similarity

The PDZ domain binds to the last three or four amino acids of ion channels and receptor proteins. The association with dystrophin or related proteins probably leaves the PDZ domain available to recruit proteins to the membrane (By similarity).By similarity

The SU domain binds calmodulin in a calcium-dependent manner.By similarity

Sequence similaritiesⁱ

Belongs to the syntrophin family.Curated

Keywords - Domainⁱ

Repeat

Phylogenomic databases

eggNOGⁱ	ENOG410IMRM Eukaryota ENOG410XS4Y LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00550000074581
HOGENOMⁱ	HOG000231596
HOVERGENⁱ	HBG054204
InParanoidⁱ	Q13424
OMAⁱ	IGWLTEQ
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0O31
PhylomeDBⁱ	Q13424
TreeFamⁱ	TF317932

Family and domain databases

Gene3Dⁱ	2.30.29.30, 2 hits
InterProⁱ	View protein in InterPro IPR001478 PDZ IPR036034 PDZ_sf IPR011993 PH-like_dom_sf IPR001849 PH_domain IPR028552 SNTA1 IPR015482 Syntrophin
PANTHERⁱ	PTHR10554 PTHR10554, 1 hit PTHR10554:SF6 PTHR10554:SF6, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00595 PDZ, 1 hit PF00169 PH, 1 hit
SMARTⁱ	View protein in SMART SM00228 PDZ, 1 hit SM00233 PH, 2 hits
SUPFAMⁱ	SSF50156 SSF50156, 1 hit
PROSITEⁱ	View protein in PROSITE PS50106 PDZ, 1 hit PS50003 PH_DOMAIN, 2 hits

Sequences (2)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

Isoform 1 (identifier: Q13424-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MASGRRAPRT GLLELRAGAG SGAGGERWQR VLLSLAEDVL TVSPADGDPG 
        60         70         80         90        100
PEPGAPREQE PAQLNGAAEP GAGPPQLPEA LLLQRRRVTV RKADAGGLGI 
       110        120        130        140        150
SIKGGRENKM PILISKIFKG LAADQTEALF VGDAILSVNG EDLSSATHDE 
       160        170        180        190        200
AVQVLKKTGK EVVLEVKYMK DVSPYFKNST GGTSVGWDSP PASPLQRQPS 
       210        220        230        240        250
SPGPTPRNFS EAKHMSLKMA YVSKRCTPND PEPRYLEICS ADGQDTLFLR 
       260        270        280        290        300
AKDEASARSW ATAIQAQVNT LTPRVKDELQ ALLAATSTAG SQDIKQIGWL 
       310        320        330        340        350
TEQLPSGGTA PTLALLTEKE LLLYLSLPET REALSRPART APLIATRLVH 
       360        370        380        390        400
SGPSKGSVPY DAELSFALRT GTRHGVDTHL FSVESPQELA AWTRQLVDGC 
       410        420        430        440        450
HRAAEGVQEV STACTWNGRP CSLSVHIDKG FTLWAAEPGA ARAVLLRQPF 
       460        470        480        490        500
EKLQMSSDDG ASLLFLDFGG AEGEIQLDLH SCPKTIVFII HSFLSAKVTR 

LGLLA

Length:505

Mass (Da):53,895

Last modified:November 1, 1996 - v1

Checksum:ⁱC07DA5F21C775CF8

GO

Isoform 2 (identifier: Q13424-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
254-328: Missing.

« Hide

        10         20         30         40         50
MASGRRAPRT GLLELRAGAG SGAGGERWQR VLLSLAEDVL TVSPADGDPG 
        60         70         80         90        100
PEPGAPREQE PAQLNGAAEP GAGPPQLPEA LLLQRRRVTV RKADAGGLGI 
       110        120        130        140        150
SIKGGRENKM PILISKIFKG LAADQTEALF VGDAILSVNG EDLSSATHDE 
       160        170        180        190        200
AVQVLKKTGK EVVLEVKYMK DVSPYFKNST GGTSVGWDSP PASPLQRQPS 
       210        220        230        240        250
SPGPTPRNFS EAKHMSLKMA YVSKRCTPND PEPRYLEICS ADGQDTLFLR 
       260        270        280        290        300
AKDETREALS RPARTAPLIA TRLVHSGPSK GSVPYDAELS FALRTGTRHG 
       310        320        330        340        350
VDTHLFSVES PQELAAWTRQ LVDGCHRAAE GVQEVSTACT WNGRPCSLSV 
       360        370        380        390        400
HIDKGFTLWA AEPGAARAVL LRQPFEKLQM SSDDGASLLF LDFGGAEGEI 
       410        420        430
QLDLHSCPKT IVFIIHSFLS AKVTRLGLLA

Note: No experimental confirmation available.

Show »

Length:430

Mass (Da):45,951

Checksum:ⁱCC6ACFC81506F650

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	6	R → P in AAB36398 (PubMed:8612778).Curated	1
Sequence conflictⁱ	25	G → A in AAB36398 (PubMed:8612778).Curated	1
Sequence conflictⁱ	32 – 33	LL → PV in AAB36398 (PubMed:8612778).Curated	2
Sequence conflictⁱ	66	G → D in AAB36398 (PubMed:8612778).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_062399	257	A → G in LQT12; leads to a gain of function of the voltage dependent sodium channel. 1 PublicationCorresponds to variant dbSNP:rs56157422EnsemblClinVar.	1
Natural variantⁱVAR_014075	364	L → F. Corresponds to variant dbSNP:rs1046815Ensembl.	1
Natural variantⁱVAR_062400	390	A → V in LQT12; results in released inhibition of nNOS, S-nitrosylation of SCN5A and increased late sodium current. 1 PublicationCorresponds to variant dbSNP:rs121434500EnsemblClinVar.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_056827	254 – 328	Missing in isoform 2. 1 PublicationAdd BLAST		75

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U40571 mRNA Translation: AAC50448.1 S81737 mRNA Translation: AAB36398.1 AL355392 Genomic DNA No translation available. AK291994 mRNA Translation: BAF84683.1 AK301800 mRNA Translation: BAG63252.1 CH471077 Genomic DNA Translation: EAW76316.1 CH471077 Genomic DNA Translation: EAW76317.1 BC026215 mRNA Translation: AAH26215.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS13220.1 [Q13424-1]
PIRⁱ	S62894
NCBI Reference Sequences More...RefSeqⁱ	NP_003089.1, NM_003098.2 [Q13424-1]
UniGeneⁱ	Hs.31121

Genome annotation databases

Ensemblⁱ	ENST00000217381; ENSP00000217381; ENSG00000101400 [Q13424-1]
GeneIDⁱ	6640
KEGGⁱ	hsa:6640
UCSC genome browser More...UCSCⁱ	uc002wzd.2 human [Q13424-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q13424	Syntrophin, alpha 1 (Dystrophin-associated protein A1, 59kDa, acidic component), isoform CRA_a		HUMAN		396	UniRef100_Q13424

Protein	Similar proteins		Species	Score	Length	Source
Q13424	Alpha-1-syntrophin		RABIT		505	UniRef90_Q13424
Alpha-1-syntrophin		BOVIN		505
Alpha-1-syntrophin	)	MOUSE		503
Syntrophin, alpha 1 (Dystrophin-associated protein A1, 59kDa, acidic component), isoform CRA_a		HUMAN		396
Uncharacterized protein		SHEEP		598
+90
Q13424-2	alpha-1-syntrophin isoform X2		ODORO		430	UniRef90_Q13424-2
alpha-1-syntrophin isoform X2		LIPVE		430
UPI0003F15B89		CHRAS		430
UPI00045DAA2C		Orycteropus afer afer		430
UPI00046BD744		EPTFU		430
+4

Protein	Similar proteins		Species	Score	Length	Source
Q13424	Alpha-1-syntrophin		RABIT		505	UniRef50_Q13424
Alpha-1-syntrophin		BOVIN		505
Alpha-1-syntrophin	)	MOUSE		503
Syntrophin, alpha 1 (Dystrophin-associated protein A1, 59kDa, acidic component), isoform CRA_a		HUMAN		396
Uncharacterized protein		SHEEP		598
+137
Q13424-2	alpha-1-syntrophin isoform X2		ODORO		430	UniRef50_Q13424-2
alpha-1-syntrophin isoform X2		LIPVE		430
Alpha-1-syntrophin		CHEMY		385
Syntrophin alpha 1		ICTTR		453
Syntrophin alpha 1		SAIBB		420
+17

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U40571 mRNA Translation: AAC50448.1 S81737 mRNA Translation: AAB36398.1 AL355392 Genomic DNA No translation available. AK291994 mRNA Translation: BAF84683.1 AK301800 mRNA Translation: BAG63252.1 CH471077 Genomic DNA Translation: EAW76316.1 CH471077 Genomic DNA Translation: EAW76317.1 BC026215 mRNA Translation: AAH26215.1
CCDSⁱ	CCDS13220.1 [Q13424-1]
PIRⁱ	S62894
RefSeqⁱ	NP_003089.1, NM_003098.2 [Q13424-1]
UniGeneⁱ	Hs.31121

3D structure databases

ProteinModelPortalⁱ	Q13424
SMRⁱ	Q13424
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	112523, 84 interactors
DIPⁱ	DIP-966N
IntActⁱ	Q13424, 7 interactors
MINTⁱ	Q13424
STRINGⁱ	9606.ENSP00000217381

PTM databases

iPTMnetⁱ	Q13424
PhosphoSitePlusⁱ	Q13424

Polymorphism and mutation databases

BioMutaⁱ	SNTA1
DMDMⁱ	23822157

Proteomic databases

EPDⁱ	Q13424
MaxQBⁱ	Q13424
PaxDbⁱ	Q13424
PeptideAtlasⁱ	Q13424
PRIDEⁱ	Q13424
ProteomicsDBⁱ	59409

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	6640
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000217381; ENSP00000217381; ENSG00000101400 [Q13424-1]
GeneIDⁱ	6640
KEGGⁱ	hsa:6640
UCSCⁱ	uc002wzd.2 human [Q13424-1]

Organism-specific databases

CTDⁱ	6640
DisGeNETⁱ	6640
EuPathDBⁱ	HostDB:ENSG00000101400.5
GeneCardsⁱ	SNTA1
GeneReviewsⁱ	SNTA1
HGNCⁱ	HGNC:11167 SNTA1
HPAⁱ	CAB037059
MalaCardsⁱ	SNTA1
MIMⁱ	601017 gene 612955 phenotype
neXtProtⁱ	NX_Q13424
OpenTargetsⁱ	ENSG00000101400
Orphanetⁱ	101016 Romano-Ward syndrome
PharmGKBⁱ	PA36007
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IMRM Eukaryota ENOG410XS4Y LUCA
GeneTreeⁱ	ENSGT00550000074581
HOGENOMⁱ	HOG000231596
HOVERGENⁱ	HBG054204
InParanoidⁱ	Q13424
OMAⁱ	IGWLTEQ
OrthoDBⁱ	EOG091G0O31
PhylomeDBⁱ	Q13424
TreeFamⁱ	TF317932

Enzyme and pathway databases

SIGNORⁱ	Q13424

SIGNORⁱ

Q13424

Miscellaneous databases

ChiTaRSⁱ	SNTA1 human
GeneWikiⁱ	Syntrophin,_alpha_1
GenomeRNAiⁱ	6640
Protein Ontology More...PROⁱ	PR:Q13424
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000101400 Expressed in 207 organ(s), highest expression level in apex of heart
CleanExⁱ	HS_SNTA1
Genevisibleⁱ	Q13424 HS

Family and domain databases

Gene3Dⁱ	2.30.29.30, 2 hits
InterProⁱ	View protein in InterPro IPR001478 PDZ IPR036034 PDZ_sf IPR011993 PH-like_dom_sf IPR001849 PH_domain IPR028552 SNTA1 IPR015482 Syntrophin
PANTHERⁱ	PTHR10554 PTHR10554, 1 hit PTHR10554:SF6 PTHR10554:SF6, 1 hit
Pfamⁱ	View protein in Pfam PF00595 PDZ, 1 hit PF00169 PH, 1 hit
SMARTⁱ	View protein in SMART SM00228 PDZ, 1 hit SM00233 PH, 2 hits
SUPFAMⁱ	SSF50156 SSF50156, 1 hit
PROSITEⁱ	View protein in PROSITE PS50106 PDZ, 1 hit PS50003 PH_DOMAIN, 2 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	SNTA1_HUMAN
Accessionⁱ	Q13424Primary (citable) accession number: Q13424 Secondary accession number(s): A8K7H9 , B4DX40, E1P5N1, Q16438
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 10, 2002
	Last sequence update:	November 1, 1996
	Last modified:	September 12, 2018
	This is version 176 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 20
Human chromosome 20: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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UniProtKB - Q13424 (SNTA1_HUMAN)

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Alpha-1-syntrophin

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Cytoskeleton

Plasma membrane

Other locations

Cytoskeleton

Plasma Membrane

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Keywords - Diseasei

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

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Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

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Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ