Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Due to a server migration, the UniProt 'ID mapping', 'Peptide search' and 'community bibliography submission' tools will not be available on the 19th April 2021 during the morning (EST).

UniProtKB - Q13422 (IKZF1_HUMAN)

Entry version 201 (07 Apr 2021)
Sequence version 1 (01 Nov 1996)
Previous versions | rss
Add a publicationFeedback
Protein

DNA-binding protein Ikaros

Gene

IKZF1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Transcription regulator of hematopoietic cell differentiation (PubMed:17934067). Binds gamma-satellite DNA (PubMed:17135265, PubMed:19141594). Plays a role in the development of lymphocytes, B- and T-cells. Binds and activates the enhancer (delta-A element) of the CD3-delta gene. Repressor of the TDT (fikzfterminal deoxynucleotidyltransferase) gene during thymocyte differentiation. Regulates transcription through association with both HDAC-dependent and HDAC-independent complexes. Targets the 2 chromatin-remodeling complexes, NuRD and BAF (SWI/SNF), in a single complex (PYR complex), to the beta-globin locus in adult erythrocytes. Increases normal apoptosis in adult erythroid cells. Confers early temporal competence to retinal progenitor cells (RPCs) (By similarity). Function is isoform-specific and is modulated by dominant-negative inactive isoforms (PubMed:17135265, PubMed:17934067).By similarity4 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei159Required for both pericentromeric heterochromatin localization and complete DNA bindingBy similarity1
Sitei162Required for both pericentromeric heterochromatin localization and complete DNA bindingBy similarity1
Sitei188Required for both pericentromeric heterochromatin localization and DNA bindingBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri117 – 139C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri145 – 167C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri173 – 195C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri201 – 224C2H2-type 4PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri462 – 484C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri490 – 514C2H2-type 6PROSITE-ProRule annotationAdd BLAST25

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, Chromatin regulator, Developmental protein, DNA-binding, Repressor
Biological processCell cycle, Transcription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q13422

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-9013508, NOTCH3 Intracellular Domain Regulates Transcription [Q13422-1]

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q13422

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q13422

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
DNA-binding protein Ikaros
Alternative name(s):
Ikaros family zinc finger protein 1
Lymphoid transcription factor LyF-1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:IKZF1
Synonyms:IK1, IKAROS, LYF1, ZNFN1A1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:13176, IKZF1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		603023, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q13422

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000185811.16

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Defects in IKZF1 are frequent occurrences (28.6%) in acute lymphoblasic leukemia (ALL). Such alterations or deletions lead to poor prognosis for ALL.
Chromosomal aberrations involving IKZF1 are a cause of B-cell non-Hodgkin lymphomas (B-cell NHL). Translocation t(3;7)(q27;p12), with BCL6.
Immunodeficiency, common variable, 13 (CVID13)2 Publications
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. CVID13 is an autosomal dominant disease associated with a striking decrease in B-cell numbers.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_076401162R → L in CVID13; abolishes binding to DNA; has diffuse nuclear localization. 1 PublicationCorresponds to variant dbSNP:rs770551610EnsemblClinVar.1
Natural variantiVAR_076402162R → Q in CVID13; abolishes binding to DNA; has diffuse nuclear localization. 1 PublicationCorresponds to variant dbSNP:rs770551610EnsemblClinVar.1
Natural variantiVAR_076403167H → R in CVID13; abolishes binding to DNA; has diffuse nuclear localization. 1 PublicationCorresponds to variant dbSNP:rs869312884EnsemblClinVar.1
Natural variantiVAR_076404184R → Q in CVID13; abolishes binding to DNA; has diffuse nuclear localization. 1 PublicationCorresponds to variant dbSNP:rs869312885EnsemblClinVar.1
Natural variantiVAR_076405210Y → C in CVID13; decreases binding to pericentromeric heterochromatin DNA; has diffuse nuclear localization. 2 PublicationsCorresponds to variant dbSNP:rs869312883EnsemblClinVar.1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi159N → A: Abolishes binding to DNA and has diffuse nuclear localization. 1 Publication1
Mutagenesisi191H → R: Abolishes binding to DNA and has diffuse nuclear localization. 1 Publication1

Keywords - Diseasei

Disease variant

Organism-specific databases

DisGeNET

More...DisGeNETi		10320

MalaCards human disease database

More...MalaCardsi		IKZF1
MIMi616873, phenotype

Open Targets

More...OpenTargetsi		ENSG00000185811

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		317473, Pancytopenia due to IKZF1 mutations
99860, Precursor B-cell acute lymphoblastic leukemia
36426, Stevens-Johnson syndrome

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA37748

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q13422, Tbio

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL4296103

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		IKZF1

Domain mapping of disease mutations (DMDM)

More...DMDMi		3913926

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000470941 – 519DNA-binding protein IkarosAdd BLAST519

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei13PhosphoserineBy similarity1
Modified residuei23PhosphothreonineBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki58Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)By similarity
Modified residuei63PhosphoserineCombined sources1
Modified residuei101PhosphoserineBy similarity1
Modified residuei140PhosphothreonineBy similarity1
Modified residuei168PhosphoserineBy similarity1
Modified residuei196PhosphoserineBy similarity1
Cross-linki241Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)By similarity
Modified residuei258PhosphoserineCombined sources1
Modified residuei261PhosphoserineCombined sources1
Modified residuei289PhosphoserineCombined sources1
Modified residuei295PhosphoserineBy similarity1
Modified residuei298PhosphoserineCombined sources1
Modified residuei361PhosphoserineCombined sources1 Publication1
Modified residuei364PhosphoserineCombined sources1 Publication1
Modified residuei368PhosphoserineCombined sources1
Modified residuei389PhosphoserineBy similarity1
Modified residuei391PhosphoserineBy similarity1
Modified residuei393PhosphoserineBy similarity1
Modified residuei397PhosphoserineBy similarity1
Modified residuei398PhosphothreonineBy similarity1
Modified residuei402PhosphoserineBy similarity1
Modified residuei427PhosphoserineCombined sources1
Modified residuei445PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylation controls cell-cycle progression from late G1 stage to S stage. Hyperphosphorylated during G2/M phase. Dephosphorylated state during late G1 phase. Phosphorylation on Thr-140 is required for DNA and pericentromeric location during mitosis. CK2 is the main kinase, in vitro. GSK3 and CDK may also contribute to phosphorylation of the C-terminal serine and threonine residues. Phosphorylation on these C-terminal residues reduces the DNA-binding ability. Phosphorylation/dephosphorylation events on Ser-13 and Ser-295 regulate TDT expression during thymocyte differentiation. Dephosphorylation by protein phosphatase 1 regulates stability and pericentromeric heterochromatin location. Phosphorylated in both lymphoid and non-lymphoid tissues (By similarity). Phosphorylation at Ser-361 and Ser-364 downstream of SYK induces nuclear translocation.By similarity2 Publications
Sumoylated. Simulataneous sumoylation on the 2 sites results in a loss of both HDAC-dependent and HDAC-independent repression. Has no effect on pericentromeric heterochromatin location. Desumoylated by SENP1 (By similarity).By similarity
Polyubiquitinated.By similarity

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q13422

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q13422

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q13422

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q13422

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q13422

PeptideAtlas

More...PeptideAtlasi		Q13422

PRoteomics IDEntifications database

More...PRIDEi		Q13422

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		59401 [Q13422-1]
59402 [Q13422-2]
59403 [Q13422-3]
59404 [Q13422-4]
59405 [Q13422-5]
59406 [Q13422-6]
59407 [Q13422-7]
66152

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q13422, 2 sites, 1 O-linked glycan (2 sites)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q13422

MetOSite database of methionine sulfoxide sites

More...MetOSitei		Q13422

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q13422

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Abundantly expressed in thymus, spleen and peripheral blood Leukocytes and lymph nodes. Lower expression in bone marrow and small intestine.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000185811, Expressed in leukocyte and 202 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q13422, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q13422, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000185811, Tissue enhanced (blood, bone marrow, lymphoid tissue)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterodimer formed by the various isoforms; this modulates transcription regulator activity (PubMed:17135265, PubMed:17934067). Heterodimer with other IKAROS family members.

Interacts with IKZF4 AND IKZF5 (PubMed:10978333).

Component of the chromatin-remodeling NuRD repressor complex which includes at least HDAC1, HDAC2, RBBP4, RBBP7, IKZF1, MTA2, MBD2, MBD3, MTA1L1, CHD3 and CHD4.

Interacts directly with the CHD4 component of the NuRD complex.

Interacts directly with SMARCA4; the interaction associates IKFZ1 with the BAF complex (PubMed:10204490).

Interacts with SUMO1; the interaction sumoylates IKAROS, promoted by PIAS2 and PIAS3.

Interacts with PIAS2 (isoform alpha); the interaction promotes sumoylation and reduces transcription repression.

Interacts, to a lesser extent, with PIAS3.

Interacts with PPP1CC; the interaction targets PPP1CC to pericentromeric heterochromatin, dephosphorylates IKAROS, stabilizes it and prevents it from degradation.

Interacts with IKZF3 (By similarity).

By similarity2 Publications2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Q13422
With#Exp.IntAct
AEN [Q8WTP8]3EBI-745305,EBI-8637627
ALKBH3 [Q96Q83]5EBI-745305,EBI-6658697
AP1M1 [Q9BXS5]3EBI-745305,EBI-541426
ARMC7 [Q9H6L4]3EBI-745305,EBI-742909
BYSL [Q13895]5EBI-745305,EBI-358049
C1orf109 [Q9NX04]3EBI-745305,EBI-8643161
C1orf174 [Q8IYL3]4EBI-745305,EBI-715898
C8orf33 [Q9H7E9]3EBI-745305,EBI-715389
CBX8 [Q9HC52]3EBI-745305,EBI-712912
CEP57L1 - isoform 2 [Q8IYX8-2]3EBI-745305,EBI-10181988
CKS1B [P61024]3EBI-745305,EBI-456371
CTBP1 - isoform 2 [Q13363-2]3EBI-745305,EBI-10171858
CTBP2 [P56545]5EBI-745305,EBI-741533
CTBP2 - isoform 3 [P56545-3]3EBI-745305,EBI-10171902
DCX [O43602]4EBI-745305,EBI-8646694
DDX6 [P26196]3EBI-745305,EBI-351257
DYRK2 [Q92630]3EBI-745305,EBI-749432
FAM161A [Q3B820]3EBI-745305,EBI-719941
FAM214B [Q7L5A3]6EBI-745305,EBI-745689
FAM50B [Q9Y247]4EBI-745305,EBI-742802
FAM74A6 [Q5TZK3]3EBI-745305,EBI-10247271
FGF12 [P61328]3EBI-745305,EBI-6657662
FRMD6 [Q96NE9]3EBI-745305,EBI-741729
GLRX3 [O76003]3EBI-745305,EBI-374781
GMCL2 [Q8NEA9]3EBI-745305,EBI-745707
ISCU [Q9H1K1]3EBI-745305,EBI-1047335
LMO3 [Q8TAP4]3EBI-745305,EBI-742259
LSM4 [Q9Y4Z0]3EBI-745305,EBI-372521
MAD2L2 [Q9UI95]3EBI-745305,EBI-77889
MCRS1 [Q96EZ8]3EBI-745305,EBI-348259
MORF4L1 [Q9UBU8]3EBI-745305,EBI-399246
MORF4L2 [Q15014]3EBI-745305,EBI-399257
MTA1 [Q13330]3EBI-745305,EBI-714236
NEK6 [Q9HC98]3EBI-745305,EBI-740364
NOC4L [Q9BVI4]3EBI-745305,EBI-395927
PIN1 [Q13526]3EBI-745305,EBI-714158
PNKP [Q96T60]3EBI-745305,EBI-1045072
PRKAB2 [O43741]3EBI-745305,EBI-1053424
PSMA1 [P25786]3EBI-745305,EBI-359352
PSMA4 [P25789]3EBI-745305,EBI-359310
RAD51D [O75771]5EBI-745305,EBI-1055693
RWDD2B [P57060]4EBI-745305,EBI-724442
SCNM1 [Q9BWG6]3EBI-745305,EBI-748391
SDCBP [O00560]3EBI-745305,EBI-727004
SH2D4A [Q9H788]3EBI-745305,EBI-747035
SHFL [Q9NUL5]3EBI-745305,EBI-10313866
SNRPF [P62306]3EBI-745305,EBI-356900
SNW1 [Q13573]3EBI-745305,EBI-632715
SPATC1L [Q9H0A9]3EBI-745305,EBI-372911
SYT17 [Q9BSW7]3EBI-745305,EBI-745392
UBE2I [Q7KZS0]3EBI-745305,EBI-10180829
WTAP [Q15007]3EBI-745305,EBI-751647
ZMAT2 [Q96NC0]3EBI-745305,EBI-2682299
ZNF417 [Q8TAU3]3EBI-745305,EBI-740727
ZNF581 [Q9P0T4]3EBI-745305,EBI-745520
A8K9323EBI-745305,EBI-10174671
IKZF1 - isoform Ik7 [Q13422-7]
With#Exp.IntAct
ANKRD36 [A1A5B0]3EBI-11522367,EBI-14100900
AP1M1 [Q9BXS5]3EBI-11522367,EBI-541426
BARD1 [Q99728]3EBI-11522367,EBI-473181
BYSL [Q13895]3EBI-11522367,EBI-358049
C1orf109 [Q9NX04]3EBI-11522367,EBI-8643161
C1orf174 [Q8IYL3]3EBI-11522367,EBI-715898
C8orf33 [Q9H7E9]3EBI-11522367,EBI-715389
CBX8 [Q9HC52]3EBI-11522367,EBI-712912
CCDC185 [Q8N715]3EBI-11522367,EBI-740814
CDC7 [O00311]3EBI-11522367,EBI-374980
CDKL3 [Q8IVW4]3EBI-11522367,EBI-3919850
CKS1B [P61024]3EBI-11522367,EBI-456371
CRBN - isoform 2 [Q96SW2-2]2EBI-11522367,EBI-10693561
CTBP1 - isoform 2 [Q13363-2]5EBI-11522367,EBI-10171858
CTBP2 - isoform 3 [P56545-3]3EBI-11522367,EBI-10171902
CWF19L2 [Q2TBE0]3EBI-11522367,EBI-5453285
DCX - isoform 2 [O43602-2]3EBI-11522367,EBI-14148644
DDX6 [P26196]3EBI-11522367,EBI-351257
FAM214B [Q7L5A3]3EBI-11522367,EBI-745689
FHL2 [Q14192]3EBI-11522367,EBI-701903
FRMD6 - isoform 2 [Q96NE9-2]3EBI-11522367,EBI-13213391
itself3EBI-11522367,EBI-11522367
LHX4 [A0A0S2Z5S9]3EBI-11522367,EBI-16429099
LMO1 [P25800]3EBI-11522367,EBI-8639312
LMO2 - isoform 3 [P25791-3]3EBI-11522367,EBI-11959475
LMO3 - isoform 4 [Q8TAP4-4]3EBI-11522367,EBI-11742507
LMO4 [P61968]3EBI-11522367,EBI-2798728
MAGOHB [Q96A72]3EBI-11522367,EBI-746778
MAPRE3 [Q9UPY8]3EBI-11522367,EBI-726739
MCRS1 [Q96EZ8]3EBI-11522367,EBI-348259
MEOX2 [Q6FHY5]3EBI-11522367,EBI-16439278
MOS [P00540]3EBI-11522367,EBI-1757866
NME7 [Q9Y5B8]6EBI-11522367,EBI-744782
NUDT21 [O43809]3EBI-11522367,EBI-355720
PIAS2 - isoform PIAS2-alpha [O75928-2]3EBI-11522367,EBI-348567
PIN1 [Q13526]3EBI-11522367,EBI-714158
PNKP [Q96T60]3EBI-11522367,EBI-1045072
PPL [O60437]3EBI-11522367,EBI-368321
PRKAA2 [P54646]3EBI-11522367,EBI-1383852
PRPF18 [Q99633]3EBI-11522367,EBI-2798416
PSMA4 [P25789]3EBI-11522367,EBI-359310
QARS1 [P47897]3EBI-11522367,EBI-347462
RAD51D [O75771]3EBI-11522367,EBI-1055693
RBM43 [Q6ZSC3]3EBI-11522367,EBI-2880658
RNF4 [P78317]3EBI-11522367,EBI-2340927
RNF6 [A0A0S2Z4G9]3EBI-11522367,EBI-16428950
SCNM1 [Q9BWG6]3EBI-11522367,EBI-748391
SNRPA1 [P09661]3EBI-11522367,EBI-876439
SNRPF [P62306]3EBI-11522367,EBI-356900
TCEA2 [Q15560]3EBI-11522367,EBI-710310
TSTD2 [Q5T7W7]3EBI-11522367,EBI-8994397
TXK [P42681]3EBI-11522367,EBI-7877438
UBE2I [Q7KZS0]3EBI-11522367,EBI-10180829
WTAP [Q15007]7EBI-11522367,EBI-751647
ZNF417 [Q8TAU3]3EBI-11522367,EBI-740727
ZNF580 [Q9UK33]3EBI-11522367,EBI-746277
ZNF587 [Q96SQ5]3EBI-11522367,EBI-6427977

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		115604, 180 interactors

Database of interacting proteins

More...DIPi		DIP-41110N

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...ELMi		Q13422

Protein interaction database and analysis system

More...IntActi		Q13422, 133 interactors

Molecular INTeraction database

More...MINTi		Q13422

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000331614

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q13422, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1519
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q13422

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni154 – 163Required for both high-affinity DNA binding and pericentromeric heterochromatin localizationBy similarity10
Regioni180 – 195Required for both high-affinity DNA binding and pericentromeric heterochromatin localizationBy similarityAdd BLAST16
Regioni468 – 471Required for binding PP1CCBy similarity4

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi373 – 376Poly-Leu4

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The N-terminal zinc-fingers 2 and 3 are required for DNA binding as well as for targeting IKFZ1 to pericentromeric heterochromatin.By similarity
The C-terminal zinc-finger domain is required for dimerization.By similarity

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the Ikaros C2H2-type zinc-finger protein family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri117 – 139C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri145 – 167C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri173 – 195C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri201 – 224C2H2-type 4PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri462 – 484C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri490 – 514C2H2-type 6PROSITE-ProRule annotationAdd BLAST25

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1721, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000156782

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_025502_2_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q13422

Identification of Orthologs from Complete Genome Data

More...OMAi		NMHRHRM

Database of Orthologous Groups

More...OrthoDBi		385551at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q13422

TreeFam database of animal gene trees

More...TreeFami		TF331189

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00096, zf-C2H2, 3 hits

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00355, ZnF_C2H2, 6 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF57667, SSF57667, 3 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00028, ZINC_FINGER_C2H2_1, 5 hits
PS50157, ZINC_FINGER_C2H2_2, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (8+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 8 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 8 described isoforms and 9 potential isoforms that are computationally mapped.Show allAlign All

Isoform Ik1 (identifier: Q13422-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDADEGQDMS QVSGKESPPV SDTPDEGDEP MPIPEDLSTT SGGQQSSKSD 
        60         70         80         90        100
RVVASNVKVE TQSDEENGRA CEMNGEECAE DLRMLDASGE KMNGSHRDQG 
       110        120        130        140        150
SSALSGVGGI RLPNGKLKCD ICGIICIGPN VLMVHKRSHT GERPFQCNQC 
       160        170        180        190        200
GASFTQKGNL LRHIKLHSGE KPFKCHLCNY ACRRRDALTG HLRTHSVGKP 
       210        220        230        240        250
HKCGYCGRSY KQRSSLEEHK ERCHNYLESM GLPGTLYPVI KEETNHSEMA 
       260        270        280        290        300
EDLCKIGSER SLVLDRLASN VAKRKSSMPQ KFLGDKGLSD TPYDSSASYE 
       310        320        330        340        350
KENEMMKSHV MDQAINNAIN YLGAESLRPL VQTPPGGSEV VPVISPMYQL 
       360        370        380        390        400
HKPLAEGTPR SNHSAQDSAV ENLLLLSKAK LVPSEREASP SNSCQDSTDT 
       410        420        430        440        450
ESNNEEQRSG LIYLTNHIAP HARNGLSLKE EHRAYDLLRA ASENSQDALR 
       460        470        480        490        500
VVSTSGEQMK VYKCEHCRVL FLDHVMYTIH MGCHGFRDPF ECNMCGYHSQ 
       510 
DRYEFSSHIT RGEHRFHMS
Length:519
Mass (Da):57,528
Last modified:November 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7B0129C4E3FE41A8
GO
Isoform Ik2 (identifier: Q13422-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     54-140: Missing.

Show »
Length:432
Mass (Da):48,289
Checksum:iE8E57F8BF5B306E6
GO
Isoform Ik3 (identifier: Q13422-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     197-283: Missing.

Show »
Length:432
Mass (Da):47,634
Checksum:i1093D253341A95E8
GO
Isoform Ik4 (identifier: Q13422-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     10-53: Missing.
     197-283: Missing.

Show »
Length:388
Mass (Da):43,093
Checksum:i137C942A5278A9F0
GO
Isoform Ik5 (identifier: Q13422-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     141-283: Missing.

Show »
Length:376
Mass (Da):41,229
Checksum:i0B060551CB3E0082
GO
Isoform Ik6 (identifier: Q13422-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     54-283: Missing.

Show »
Length:289
Mass (Da):31,989
Checksum:iEB96A15185C62A18
GO
Isoform Ik7 (identifier: Q13422-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     197-238: Missing.

Show »
Length:477
Mass (Da):52,706
Checksum:iB19FE76450EA40E4
GO
Isoform Ikx (identifier: Q13422-8) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     197-238: Missing.
     260-268: RSLVLDRLA → ISRAGQTSK
     269-519: Missing.

Show »
Length:226
Mass (Da):24,470
Checksum:i2BB5B70D38F73264
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
R9R4D9R9R4D9_HUMAN
DNA-binding protein Ikaros
IKZF1
268Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0A0MRA0A0A0A0MRA0_HUMAN
DNA-binding protein Ikaros
IKZF1
249Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WU46A0A087WU46_HUMAN
DNA-binding protein Ikaros
IKZF1
336Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0A0MST1A0A0A0MST1_HUMAN
DNA-binding protein Ikaros
IKZF1
294Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q3T907Q3T907_HUMAN
DNA-binding protein Ikaros
IKZF1 ZNFN1A1
67Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8Y4T7A0A2R8Y4T7_HUMAN
DNA-binding protein Ikaros
IKZF1
170Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8Y4D3A0A2R8Y4D3_HUMAN
DNA-binding protein Ikaros
IKZF1
77Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8YFR0A0A2R8YFR0_HUMAN
DNA-binding protein Ikaros
IKZF1
67Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JTB0C9JTB0_HUMAN
DNA-binding protein Ikaros
IKZF1
174Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti11 – 12QV → FS in AAB50683 (PubMed:8543809).Curated2
Sequence conflicti214S → T in AAB50683 (PubMed:8543809).Curated1
Sequence conflicti245N → K in AAB50683 (PubMed:8543809).Curated1
Sequence conflicti296Missing in AAB50683 (PubMed:8543809).Curated1
Sequence conflicti298S → T in AAB50683 (PubMed:8543809).Curated1
Sequence conflicti352 – 355KPLA → RRS in AAB50683 (PubMed:8543809).Curated4
Sequence conflicti372N → Y in AAB50683 (PubMed:8543809).Curated1
Sequence conflicti420 – 426PHARNGL → RRAQRV in AAB50683 (PubMed:8543809).Curated7

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_076401162R → L in CVID13; abolishes binding to DNA; has diffuse nuclear localization. 1 PublicationCorresponds to variant dbSNP:rs770551610EnsemblClinVar.1
Natural variantiVAR_076402162R → Q in CVID13; abolishes binding to DNA; has diffuse nuclear localization. 1 PublicationCorresponds to variant dbSNP:rs770551610EnsemblClinVar.1
Natural variantiVAR_076403167H → R in CVID13; abolishes binding to DNA; has diffuse nuclear localization. 1 PublicationCorresponds to variant dbSNP:rs869312884EnsemblClinVar.1
Natural variantiVAR_076404184R → Q in CVID13; abolishes binding to DNA; has diffuse nuclear localization. 1 PublicationCorresponds to variant dbSNP:rs869312885EnsemblClinVar.1
Natural variantiVAR_076405210Y → C in CVID13; decreases binding to pericentromeric heterochromatin DNA; has diffuse nuclear localization. 2 PublicationsCorresponds to variant dbSNP:rs869312883EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_00684710 – 53Missing in isoform Ik4. CuratedAdd BLAST44
Alternative sequenceiVSP_00684954 – 283Missing in isoform Ik6. CuratedAdd BLAST230
Alternative sequenceiVSP_00684854 – 140Missing in isoform Ik2. 1 PublicationAdd BLAST87
Alternative sequenceiVSP_006852141 – 283Missing in isoform Ik5. CuratedAdd BLAST143
Alternative sequenceiVSP_006850197 – 283Missing in isoform Ik3 and isoform Ik4. CuratedAdd BLAST87
Alternative sequenceiVSP_006851197 – 238Missing in isoform Ik7 and isoform Ikx. 3 PublicationsAdd BLAST42
Alternative sequenceiVSP_053404260 – 268RSLVLDRLA → ISRAGQTSK in isoform Ikx. 1 Publication9
Alternative sequenceiVSP_053405269 – 519Missing in isoform Ikx. 1 PublicationAdd BLAST251

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
U40462 mRNA Translation: AAC50459.1
S80876 mRNA Translation: AAB50683.1
AY377974 mRNA Translation: AAR84585.1
AK303586 mRNA Translation: BAG64603.1
BT009836 mRNA Translation: AAP88838.1
AC124014 Genomic DNA No translation available.
AC233268 Genomic DNA No translation available.
CH471128 Genomic DNA Translation: EAW60977.1
CH471128 Genomic DNA Translation: EAW60978.1
CH471128 Genomic DNA Translation: EAW60981.1
CH236955 Genomic DNA Translation: EAL23900.1
CH471128 Genomic DNA Translation: EAW60979.1
BC018349 mRNA Translation: AAH18349.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS59055.1 [Q13422-7]
CCDS69299.1 [Q13422-5]
CCDS75596.1 [Q13422-1]
CCDS75597.1 [Q13422-3]
CCDS78233.1 [Q13422-2]

NCBI Reference Sequences

More...RefSeqi		NP_001207694.1, NM_001220765.2 [Q13422-7]
NP_001207696.1, NM_001220767.2
NP_001207697.1, NM_001220768.2 [Q13422-3]
NP_001207699.1, NM_001220770.2
NP_001207700.1, NM_001220771.2 [Q13422-5]
NP_001278766.1, NM_001291837.1 [Q13422-7]
NP_001278767.1, NM_001291838.1 [Q13422-2]
NP_001278768.1, NM_001291839.1
NP_001278769.1, NM_001291840.1 [Q13422-6]
NP_001278770.1, NM_001291841.1
NP_001278771.1, NM_001291842.1
NP_001278772.1, NM_001291843.1
NP_001278773.1, NM_001291844.1
NP_006051.1, NM_006060.5 [Q13422-1]
XP_011513370.1, XM_011515068.2 [Q13422-1]
XP_011513371.1, XM_011515069.2 [Q13422-1]
XP_011513377.1, XM_011515075.2 [Q13422-2]
XP_011513378.1, XM_011515076.2 [Q13422-2]
XP_016867157.1, XM_017011668.1 [Q13422-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000331340; ENSP00000331614; ENSG00000185811 [Q13422-1]
ENST00000343574; ENSP00000342750; ENSG00000185811 [Q13422-2]
ENST00000349824; ENSP00000342485; ENSG00000185811 [Q13422-5]
ENST00000357364; ENSP00000349928; ENSG00000185811 [Q13422-3]
ENST00000359197; ENSP00000352123; ENSG00000185811 [Q13422-7]
ENST00000438033; ENSP00000396554; ENSG00000185811 [Q13422-2]
ENST00000439701; ENSP00000413025; ENSG00000185811 [Q13422-7]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		10320

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:10320

UCSC genome browser

More...UCSCi		uc003tow.5, human [Q13422-1]

Keywords - Coding sequence diversityi

Alternative splicing, Chromosomal rearrangement

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U40462 mRNA Translation: AAC50459.1
S80876 mRNA Translation: AAB50683.1
AY377974 mRNA Translation: AAR84585.1
AK303586 mRNA Translation: BAG64603.1
BT009836 mRNA Translation: AAP88838.1
AC124014 Genomic DNA No translation available.
AC233268 Genomic DNA No translation available.
CH471128 Genomic DNA Translation: EAW60977.1
CH471128 Genomic DNA Translation: EAW60978.1
CH471128 Genomic DNA Translation: EAW60981.1
CH236955 Genomic DNA Translation: EAL23900.1
CH471128 Genomic DNA Translation: EAW60979.1
BC018349 mRNA Translation: AAH18349.1
CCDSiCCDS59055.1 [Q13422-7]
CCDS69299.1 [Q13422-5]
CCDS75596.1 [Q13422-1]
CCDS75597.1 [Q13422-3]
CCDS78233.1 [Q13422-2]
RefSeqiNP_001207694.1, NM_001220765.2 [Q13422-7]
NP_001207696.1, NM_001220767.2
NP_001207697.1, NM_001220768.2 [Q13422-3]
NP_001207699.1, NM_001220770.2
NP_001207700.1, NM_001220771.2 [Q13422-5]
NP_001278766.1, NM_001291837.1 [Q13422-7]
NP_001278767.1, NM_001291838.1 [Q13422-2]
NP_001278768.1, NM_001291839.1
NP_001278769.1, NM_001291840.1 [Q13422-6]
NP_001278770.1, NM_001291841.1
NP_001278771.1, NM_001291842.1
NP_001278772.1, NM_001291843.1
NP_001278773.1, NM_001291844.1
NP_006051.1, NM_006060.5 [Q13422-1]
XP_011513370.1, XM_011515068.2 [Q13422-1]
XP_011513371.1, XM_011515069.2 [Q13422-1]
XP_011513377.1, XM_011515075.2 [Q13422-2]
XP_011513378.1, XM_011515076.2 [Q13422-2]
XP_016867157.1, XM_017011668.1 [Q13422-2]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
6H0FX-ray3.25C/F/I/L141-174[»]
SMRiQ13422
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi115604, 180 interactors
DIPiDIP-41110N
ELMiQ13422
IntActiQ13422, 133 interactors
MINTiQ13422
STRINGi9606.ENSP00000331614

Chemistry databases

ChEMBLiCHEMBL4296103

PTM databases

GlyGeniQ13422, 2 sites, 1 O-linked glycan (2 sites)
iPTMnetiQ13422
MetOSiteiQ13422
PhosphoSitePlusiQ13422

Genetic variation databases

BioMutaiIKZF1
DMDMi3913926

Proteomic databases

EPDiQ13422
jPOSTiQ13422
MassIVEiQ13422
MaxQBiQ13422
PaxDbiQ13422
PeptideAtlasiQ13422
PRIDEiQ13422
ProteomicsDBi59401 [Q13422-1]
59402 [Q13422-2]
59403 [Q13422-3]
59404 [Q13422-4]
59405 [Q13422-5]
59406 [Q13422-6]
59407 [Q13422-7]
66152

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		3980, 554 antibodies

The DNASU plasmid repository

More...DNASUi		10320

Genome annotation databases

EnsembliENST00000331340; ENSP00000331614; ENSG00000185811 [Q13422-1]
ENST00000343574; ENSP00000342750; ENSG00000185811 [Q13422-2]
ENST00000349824; ENSP00000342485; ENSG00000185811 [Q13422-5]
ENST00000357364; ENSP00000349928; ENSG00000185811 [Q13422-3]
ENST00000359197; ENSP00000352123; ENSG00000185811 [Q13422-7]
ENST00000438033; ENSP00000396554; ENSG00000185811 [Q13422-2]
ENST00000439701; ENSP00000413025; ENSG00000185811 [Q13422-7]
GeneIDi10320
KEGGihsa:10320
UCSCiuc003tow.5, human [Q13422-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		10320
DisGeNETi10320

GeneCards: human genes, protein and diseases

More...GeneCardsi		IKZF1
HGNCiHGNC:13176, IKZF1
HPAiENSG00000185811, Tissue enhanced (blood, bone marrow, lymphoid tissue)
MalaCardsiIKZF1
MIMi603023, gene
616873, phenotype
neXtProtiNX_Q13422
OpenTargetsiENSG00000185811
Orphaneti317473, Pancytopenia due to IKZF1 mutations
99860, Precursor B-cell acute lymphoblastic leukemia
36426, Stevens-Johnson syndrome
PharmGKBiPA37748
VEuPathDBiHostDB:ENSG00000185811.16

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1721, Eukaryota
GeneTreeiENSGT00940000156782
HOGENOMiCLU_025502_2_0_1
InParanoidiQ13422
OMAiNMHRHRM
OrthoDBi385551at2759
PhylomeDBiQ13422
TreeFamiTF331189

Enzyme and pathway databases

PathwayCommonsiQ13422
ReactomeiR-HSA-9013508, NOTCH3 Intracellular Domain Regulates Transcription [Q13422-1]
SignaLinkiQ13422
SIGNORiQ13422

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		10320, 30 hits in 1013 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		IKZF1, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		IKZF1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		10320
PharosiQ13422, Tbio

Protein Ontology

More...PROi		PR:Q13422
RNActiQ13422, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000185811, Expressed in leukocyte and 202 other tissues
ExpressionAtlasiQ13422, baseline and differential
GenevisibleiQ13422, HS

Family and domain databases

InterProiView protein in InterPro
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type
PfamiView protein in Pfam
PF00096, zf-C2H2, 3 hits
SMARTiView protein in SMART
SM00355, ZnF_C2H2, 6 hits
SUPFAMiSSF57667, SSF57667, 3 hits
PROSITEiView protein in PROSITE
PS00028, ZINC_FINGER_C2H2_1, 5 hits
PS50157, ZINC_FINGER_C2H2_2, 4 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiIKZF1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q13422
Secondary accession number(s): A4D260
, B4E0Z1, D3DVM5, O00598, Q53XL2, Q69BM4, Q8WVA3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: November 1, 1996
Last modified: April 7, 2021
This is version 201 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again