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Entry version 162 (16 Oct 2019)
Sequence version 2 (17 Oct 2006)
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Protein

Mesothelin

Gene

MSLN

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Membrane-anchored forms may play a role in cellular adhesion.
Megakaryocyte-potentiating factor (MPF) potentiates megakaryocyte colony formation in vitro.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell adhesion

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-163125 Post-translational modification: synthesis of GPI-anchored proteins
R-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-HSA-8957275 Post-translational protein phosphorylation

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q13421

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Mesothelin
Alternative name(s):
CAK1 antigen
Pre-pro-megakaryocyte-potentiating factor
Cleaved into the following 2 chains:
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MSLN
Synonyms:MPF
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 16

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:7371 MSLN

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
601051 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q13421

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Golgi apparatus, Membrane, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Antibodies against MSLN are detected in patients with mesothelioma and ovarian cancer.1 Publication

Organism-specific databases

DisGeNET

More...
DisGeNETi
10232

Open Targets

More...
OpenTargetsi
ENSG00000102854

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA31176

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q13421

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL3712878

Drug and drug target database

More...
DrugBanki
DB12845 Amatuximab

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
MSLN

Domain mapping of disease mutations (DMDM)

More...
DMDMi
116242654

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 361 PublicationAdd BLAST36
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000025355937 – 606MesothelinAdd BLAST570
ChainiPRO_000025356037 – 286Megakaryocyte-potentiating factorAdd BLAST250
ChainiPRO_0000253561296 – 606Mesothelin, cleaved formAdd BLAST311
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_0000021769607 – 630Removed in mature formSequence analysisAdd BLAST24

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi57N-linked (GlcNAc...) asparagineCurated1
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei200Phosphoserine; by FAM20C1 Publication1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi302 ↔ 3261 Publication
Glycosylationi388N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi496N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi523N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position(s) and the type of covalently attached lipid group(s).<p><a href='/help/lipid' target='_top'>More...</a></p>Lipidationi606GPI-anchor amidated serineSequence analysis1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Both MPF and the cleaved form of mesothelin are N-glycosylated.3 Publications
Proteolytically cleaved by a furin-like convertase to generate megakaryocyte-potentiating factor (MPF), and the cleaved form of mesothelin.1 Publication

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q13421

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q13421

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q13421

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q13421

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q13421

PeptideAtlas

More...
PeptideAtlasi
Q13421

PRoteomics IDEntifications database

More...
PRIDEi
Q13421

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
59397 [Q13421-1]
59398 [Q13421-2]
59399 [Q13421-3]
59400 [Q13421-4]

PTM databases

GlyConnect protein glycosylation platform

More...
GlyConnecti
1503

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q13421

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q13421

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q13421

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in lung. Expressed at low levels in heart, placenta and kidney. Expressed in mesothelial cells. Highly expressed in mesotheliomas, ovarian cancers, and some squamous cell carcinomas (at protein level).2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000102854 Expressed in 120 organ(s), highest expression level in right uterine tube

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q13421 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q13421 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB002216
HPA017172

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with MUC16.

2 Publications

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
115526, 14 interactors

Protein interaction database and analysis system

More...
IntActi
Q13421, 3 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000372313

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1630
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q13421

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni262 – 286Required for megakaryocyte-potentiating factor activityAdd BLAST25

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the mesothelin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IIJH Eukaryota
ENOG4111HFW LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000182957

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q13421

KEGG Orthology (KO)

More...
KOi
K20733

Identification of Orthologs from Complete Genome Data

More...
OMAi
TILRPRF

Database of Orthologous Groups

More...
OrthoDBi
459771at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q13421

TreeFam database of animal gene trees

More...
TreeFami
TF331713

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR010335 Mesothelin
IPR026664 Stereocilin-rel

The PANTHER Classification System

More...
PANTHERi
PTHR23412 PTHR23412, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF06060 Mesothelin, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q13421-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MALPTARPLL GSCGTPALGS LLFLLFSLGW VQPSRTLAGE TGQEAAPLDG
60 70 80 90 100
VLANPPNISS LSPRQLLGFP CAEVSGLSTE RVRELAVALA QKNVKLSTEQ
110 120 130 140 150
LRCLAHRLSE PPEDLDALPL DLLLFLNPDA FSGPQACTRF FSRITKANVD
160 170 180 190 200
LLPRGAPERQ RLLPAALACW GVRGSLLSEA DVRALGGLAC DLPGRFVAES
210 220 230 240 250
AEVLLPRLVS CPGPLDQDQQ EAARAALQGG GPPYGPPSTW SVSTMDALRG
260 270 280 290 300
LLPVLGQPII RSIPQGIVAA WRQRSSRDPS WRQPERTILR PRFRREVEKT
310 320 330 340 350
ACPSGKKARE IDESLIFYKK WELEACVDAA LLATQMDRVN AIPFTYEQLD
360 370 380 390 400
VLKHKLDELY PQGYPESVIQ HLGYLFLKMS PEDIRKWNVT SLETLKALLE
410 420 430 440 450
VNKGHEMSPQ APRRPLPQVA TLIDRFVKGR GQLDKDTLDT LTAFYPGYLC
460 470 480 490 500
SLSPEELSSV PPSSIWAVRP QDLDTCDPRQ LDVLYPKARL AFQNMNGSEY
510 520 530 540 550
FVKIQSFLGG APTEDLKALS QQNVSMDLAT FMKLRTDAVL PLTVAEVQKL
560 570 580 590 600
LGPHVEGLKA EERHRPVRDW ILRQRQDDLD TLGLGLQGGI PNGYLVLDLS
610 620 630
MQEALSGTPC LLGPGPVLTV LALLLASTLA
Note: Minor form.
Length:630
Mass (Da):68,986
Last modified:October 17, 2006 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFA17E3609B6CC9CA
GO
Isoform 2 (identifier: Q13421-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     409-416: Missing.

Note: Major form.
Show »
Length:622
Mass (Da):68,070
Checksum:i1F0FE52883D0DDB8
GO
Isoform 3 (identifier: Q13421-2) [UniParc]FASTAAdd to basket
Also known as: SMRP

The sequence of this isoform differs from the canonical sequence as follows:
     409-416: Missing.
     601-630: MQEALSGTPCLLGPGPVLTVLALLLASTLA → VQGGRGGQAR...HPGLRAPLPC

Note: Soluble form found in the sera from patients with ovarian carcinoma.
Show »
Length:656
Mass (Da):71,492
Checksum:iC1B783689D5DC266
GO
Isoform 4 (identifier: Q13421-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     44-44: Missing.
     409-416: Missing.

Show »
Length:621
Mass (Da):67,940
Checksum:i1A736774094C28D0
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H3BUX1H3BUX1_HUMAN
Mesothelin
MSLN
398Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BV92H3BV92_HUMAN
Mesothelin
MSLN
170Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BR90H3BR90_HUMAN
Mesothelin
MSLN
332Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BMA1H3BMA1_HUMAN
Mesothelin
MSLN
334Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti4 – 11PTARPLLG → QRLDPCW in AAC50348 (PubMed:8552591).Curated8
Sequence conflicti15 – 18TPAL → DRP in AAC50348 (PubMed:8552591).Curated4
Sequence conflicti32 – 34QPS → HPA in AAC50348 (PubMed:8552591).Curated3
Sequence conflicti43 – 45QEA → TES in AAC50348 (PubMed:8552591).Curated3
Sequence conflicti49D → G in AAC50348 (PubMed:8552591).Curated1
Sequence conflicti53 – 56ANPP → TTPH in AAC50348 (PubMed:8552591).Curated4
Sequence conflicti139R → H in AAV87530 (PubMed:15897581).Curated1
Sequence conflicti402N → D in AAC50348 (PubMed:8552591).Curated1
Sequence conflicti604A → T in AAC50348 (PubMed:8552591).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_02838172A → V. Corresponds to variant dbSNP:rs9927389Ensembl.1
Natural variantiVAR_028382309R → P1 PublicationCorresponds to variant dbSNP:rs17850474Ensembl.1
Natural variantiVAR_054012497G → E. Corresponds to variant dbSNP:rs35935235Ensembl.1
Natural variantiVAR_028383601M → V6 PublicationsCorresponds to variant dbSNP:rs1135210Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_02105844Missing in isoform 4. 1 Publication1
Alternative sequenceiVSP_021059409 – 416Missing in isoform 2, isoform 3 and isoform 4. 5 Publications8
Alternative sequenceiVSP_021060601 – 630MQEAL…ASTLA → VQGGRGGQARAGGRAGGVEV GALSHPSLCRGPLGDALPPR TWTCSHRPGTAPSLHPGLRA PLPC in isoform 3. 1 PublicationAdd BLAST30

Sequence databases

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EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
D49441 mRNA Translation: BAA08419.1
U40434 mRNA Translation: AAC50348.1
AY743922 mRNA Translation: AAV87530.1
AE006464 Genomic DNA Translation: AAK61253.1
AL031258 Genomic DNA No translation available.
CH471112 Genomic DNA Translation: EAW85719.1
CH471112 Genomic DNA Translation: EAW85720.1
BC003512 mRNA Translation: AAH03512.1
BC009272 mRNA Translation: AAH09272.1
AF180951 mRNA Translation: AAF01409.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS32356.1 [Q13421-1]
CCDS45370.1 [Q13421-3]

NCBI Reference Sequences

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RefSeqi
NP_001170826.1, NM_001177355.2 [Q13421-3]
NP_005814.2, NM_005823.5 [Q13421-3]
NP_037536.2, NM_013404.4 [Q13421-1]
XP_005255091.1, XM_005255034.4
XP_011520650.1, XM_011522348.2
XP_016878346.1, XM_017022857.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000382862; ENSP00000372313; ENSG00000102854 [Q13421-1]
ENST00000545450; ENSP00000442965; ENSG00000102854 [Q13421-3]
ENST00000563941; ENSP00000456008; ENSG00000102854 [Q13421-3]
ENST00000566549; ENSP00000456702; ENSG00000102854 [Q13421-3]

Database of genes from NCBI RefSeq genomes

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GeneIDi
10232

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:10232

UCSC genome browser

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UCSCi
uc002cjt.2 human [Q13421-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D49441 mRNA Translation: BAA08419.1
U40434 mRNA Translation: AAC50348.1
AY743922 mRNA Translation: AAV87530.1
AE006464 Genomic DNA Translation: AAK61253.1
AL031258 Genomic DNA No translation available.
CH471112 Genomic DNA Translation: EAW85719.1
CH471112 Genomic DNA Translation: EAW85720.1
BC003512 mRNA Translation: AAH03512.1
BC009272 mRNA Translation: AAH09272.1
AF180951 mRNA Translation: AAF01409.1
CCDSiCCDS32356.1 [Q13421-1]
CCDS45370.1 [Q13421-3]
RefSeqiNP_001170826.1, NM_001177355.2 [Q13421-3]
NP_005814.2, NM_005823.5 [Q13421-3]
NP_037536.2, NM_013404.4 [Q13421-1]
XP_005255091.1, XM_005255034.4
XP_011520650.1, XM_011522348.2
XP_016878346.1, XM_017022857.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4F3FX-ray2.65C302-359[»]
SMRiQ13421
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi115526, 14 interactors
IntActiQ13421, 3 interactors
STRINGi9606.ENSP00000372313

Chemistry databases

ChEMBLiCHEMBL3712878
DrugBankiDB12845 Amatuximab

PTM databases

GlyConnecti1503
iPTMnetiQ13421
PhosphoSitePlusiQ13421
SwissPalmiQ13421

Polymorphism and mutation databases

BioMutaiMSLN
DMDMi116242654

Proteomic databases

EPDiQ13421
jPOSTiQ13421
MassIVEiQ13421
MaxQBiQ13421
PaxDbiQ13421
PeptideAtlasiQ13421
PRIDEiQ13421
ProteomicsDBi59397 [Q13421-1]
59398 [Q13421-2]
59399 [Q13421-3]
59400 [Q13421-4]

Protocols and materials databases

ABCD curated depository of sequenced antibodies

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ABCDi
Q13421

The DNASU plasmid repository

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DNASUi
10232

Genome annotation databases

EnsembliENST00000382862; ENSP00000372313; ENSG00000102854 [Q13421-1]
ENST00000545450; ENSP00000442965; ENSG00000102854 [Q13421-3]
ENST00000563941; ENSP00000456008; ENSG00000102854 [Q13421-3]
ENST00000566549; ENSP00000456702; ENSG00000102854 [Q13421-3]
GeneIDi10232
KEGGihsa:10232
UCSCiuc002cjt.2 human [Q13421-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
10232
DisGeNETi10232

GeneCards: human genes, protein and diseases

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GeneCardsi
MSLN
HGNCiHGNC:7371 MSLN
HPAiCAB002216
HPA017172
MIMi601051 gene
neXtProtiNX_Q13421
OpenTargetsiENSG00000102854
PharmGKBiPA31176

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IIJH Eukaryota
ENOG4111HFW LUCA
GeneTreeiENSGT00950000182957
InParanoidiQ13421
KOiK20733
OMAiTILRPRF
OrthoDBi459771at2759
PhylomeDBiQ13421
TreeFamiTF331713

Enzyme and pathway databases

ReactomeiR-HSA-163125 Post-translational modification: synthesis of GPI-anchored proteins
R-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-HSA-8957275 Post-translational protein phosphorylation
SIGNORiQ13421

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
MSLN human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
Mesothelin

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
10232
PharosiQ13421

Protein Ontology

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PROi
PR:Q13421

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000102854 Expressed in 120 organ(s), highest expression level in right uterine tube
ExpressionAtlasiQ13421 baseline and differential
GenevisibleiQ13421 HS

Family and domain databases

InterProiView protein in InterPro
IPR010335 Mesothelin
IPR026664 Stereocilin-rel
PANTHERiPTHR23412 PTHR23412, 1 hit
PfamiView protein in Pfam
PF06060 Mesothelin, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMSLN_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q13421
Secondary accession number(s): D3DU65
, Q14859, Q4VQD5, Q96GR6, Q96KJ5, Q9BR17, Q9BTR2, Q9UCB2, Q9UK57
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: October 17, 2006
Last modified: October 16, 2019
This is version 162 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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