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Entry version 206 (07 Oct 2020)
Sequence version 3 (19 Sep 2002)
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Protein

Cytoplasmic dynein 1 intermediate chain 2

Gene

DYNC1I2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function (PubMed:31079899). Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules (PubMed:31079899). The intermediate chains mediate the binding of dynein to dynactin via its 150 kDa component (p150-glued) DCTN1 (By similarity). Involved in membrane-transport, such as Golgi apparatus, late endosomes and lysosomes (By similarity).By similarity1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionMotor protein
Biological processHost-virus interaction, Transport

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

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PathwayCommonsi
Q13409

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-141444, Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
R-HSA-2132295, MHC class II antigen presentation
R-HSA-2467813, Separation of Sister Chromatids
R-HSA-2500257, Resolution of Sister Chromatid Cohesion
R-HSA-2565942, Regulation of PLK1 Activity at G2/M Transition
R-HSA-3371497, HSP90 chaperone cycle for steroid hormone receptors (SHR)
R-HSA-380259, Loss of Nlp from mitotic centrosomes
R-HSA-380270, Recruitment of mitotic centrosome proteins and complexes
R-HSA-380284, Loss of proteins required for interphase microtubule organization from the centrosome
R-HSA-380320, Recruitment of NuMA to mitotic centrosomes
R-HSA-5620912, Anchoring of the basal body to the plasma membrane
R-HSA-5663220, RHO GTPases Activate Formins
R-HSA-6807878, COPI-mediated anterograde transport
R-HSA-6811436, COPI-independent Golgi-to-ER retrograde traffic
R-HSA-68877, Mitotic Prometaphase
R-HSA-8854518, AURKA Activation by TPX2
R-HSA-9609690, HCMV Early Events
R-HSA-9646399, Aggrephagy
R-HSA-9648025, EML4 and NUDC in mitotic spindle formation

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q13409

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cytoplasmic dynein 1 intermediate chain 2
Alternative name(s):
Cytoplasmic dynein intermediate chain 2
Dynein intermediate chain 2, cytosolic
Short name:
DH IC-2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DYNC1I2
Synonyms:DNCI2, DNCIC2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000077380.15

Human Gene Nomenclature Database

More...
HGNCi
HGNC:2964, DYNC1I2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
603331, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q13409

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Dynein, Microtubule

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Neurodevelopmental disorder with microcephaly and structural brain anomalies (NEDMIBA)1 Publication
The disease may be caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal recessive neurodevelopmental disorder characterized by global developmental delay, severe intellectual disability, microcephaly, dysmorphic facial features, and cerebral malformations including simplification of cerebral gyration, agenesis of the corpus callosum, and brainstem and white matter hypoplasia.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_082947247Y → C in NEDMIBA; loss-of-function variant; does not rescue neurodevelopmental defects in zebrafish morphants. 1 Publication1
Natural variantiVAR_082948290 – 638Missing in NEDMIBA; loss-of-function variant; does not rescue neurodevelopmental defects in zebrafish morphants. 1 PublicationAdd BLAST349

Keywords - Diseasei

Disease mutation, Mental retardation

Organism-specific databases

DisGeNET

More...
DisGeNETi
1781

MalaCards human disease database

More...
MalaCardsi
DYNC1I2
MIMi618492, phenotype

Open Targets

More...
OpenTargetsi
ENSG00000077380

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA27435

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q13409, Tbio

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL4295815

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
DYNC1I2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
23503058

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001146552 – 638Cytoplasmic dynein 1 intermediate chain 2Add BLAST637

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylserineCombined sources1
Modified residuei51DiphosphoserineBy similarity1
Modified residuei51PhosphoserineCombined sources1
Modified residuei90PhosphoserineBy similarity1
Modified residuei95PhosphothreonineCombined sources1
Modified residuei97PhosphoserineCombined sources1
Modified residuei101PhosphoserineCombined sources1
Modified residuei104PhosphoserineCombined sources1
Isoform 2B (identifier: Q13409-2)
Modified residuei73PhosphoserineCombined sources1
Modified residuei81PhosphoserineCombined sources1
Modified residuei84PhosphoserineCombined sources1
Isoform 2C (identifier: Q13409-3)
Modified residuei73PhosphoserineCombined sources1
Modified residuei81PhosphoserineCombined sources1
Modified residuei84PhosphoserineCombined sources1
Isoform 2F (identifier: Q13409-6)
Modified residuei73PhosphoserineCombined sources1
Modified residuei81PhosphoserineCombined sources1
Modified residuei84PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

The phosphorylation status of Ser-90 appears to be involved in dynactin-dependent target binding.By similarity
Pyrophosphorylation by 5-diphosphoinositol pentakisphosphate (5-IP7) promotes interaction with DCTN1. Serine pyrophosphorylation is achieved by Mg2+-dependent, but enzyme independent transfer of a beta-phosphate from a inositol pyrophosphate to a pre-phosphorylated serine residue.By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q13409

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q13409

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q13409

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q13409

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q13409

PeptideAtlas

More...
PeptideAtlasi
Q13409

PRoteomics IDEntifications database

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PRIDEi
Q13409

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
59388 [Q13409-1]
59389 [Q13409-2]
59390 [Q13409-3]
59391 [Q13409-5]
59392 [Q13409-6]
7048

2D gel databases

REPRODUCTION-2DPAGE

More...
REPRODUCTION-2DPAGEi
IPI00827813

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q13409

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q13409

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q13409

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000077380, Expressed in brain and 116 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q13409, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q13409, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000077380, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer (By similarity). The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs), light intermediate chains (LICs) and light chains (LCs); the composition seems to vary in respect to the IC, LIC and LC composition (By similarity). The heavy chain homodimer serves as a scaffold for the probable homodimeric assembly of the respective non-catalytic subunits (By similarity). The ICs and LICs bind directly to the HC dimer and the LCs assemble on the IC dimer (By similarity).

Interacts with DYNLT3 (By similarity).

Interacts with DYNLT1 (PubMed:27502274).

Interacts (dephosphorylated at Ser-90) with DCTN1 (By similarity).

Interacts with BICD2.

Interacts with SPEF2 (By similarity).

By similarity1 Publication

(Microbial infection) Interacts with human adenovirus 5 hexon protein; this interaction probably allows virus intracellular transport.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
108119, 188 interactors

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...
ELMi
Q13409

Protein interaction database and analysis system

More...
IntActi
Q13409, 38 interactors

Molecular INTeraction database

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MINTi
Q13409

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000380308

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q13409, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1638
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q13409

Database of comparative protein structure models

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ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati277 – 326WD 1Add BLAST50
Repeati330 – 370WD 2Add BLAST41
Repeati379 – 420WD 3Add BLAST42
Repeati429 – 469WD 4Add BLAST41
Repeati474 – 519WD 5Add BLAST46
Repeati522 – 562WD 6Add BLAST41
Repeati568 – 607WD 7Add BLAST40

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the dynein intermediate chain family.Curated

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG1587, Eukaryota

Ensembl GeneTree

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GeneTreei
ENSGT00940000155442

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_012999_1_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q13409

KEGG Orthology (KO)

More...
KOi
K10415

Identification of Orthologs from Complete Genome Data

More...
OMAi
TAKFSPY

Database for complete collections of gene phylogenies

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PhylomeDBi
Q13409

TreeFam database of animal gene trees

More...
TreeFami
TF300553

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.130.10.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR025956, DYNC1I1/DYNC1I2
IPR015943, WD40/YVTN_repeat-like_dom_sf
IPR001680, WD40_repeat
IPR017986, WD40_repeat_dom
IPR036322, WD40_repeat_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF11540, Dynein_IC2, 1 hit
PF00400, WD40, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00320, WD40, 5 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50978, SSF50978, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50294, WD_REPEATS_REGION, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (6+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 6 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 6 described isoforms and 12 potential isoforms that are computationally mapped.Show allAlign All

Isoform 2A (identifier: Q13409-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSDKSELKAE LERKKQRLAQ IREEKKRKEE ERKKKETDQK KEAVAPVQEE
60 70 80 90 100
SDLEKKRREA EALLQSMGLT PESPIVFSEY WVPPPMSPSS KSVSTPSEAG
110 120 130 140 150
SQDSGDGAVG SRTLHWDTDP SVLQLHSDSD LGRGPIKLGM AKITQVDFPP
160 170 180 190 200
REIVTYTKET QTPVMAQPKE DEEEDDDVVA PKPPIEPEEE KTLKKDEEND
210 220 230 240 250
SKAPPHELTE EEKQQILHSE EFLSFFDHST RIVERALSEQ INIFFDYSGR
260 270 280 290 300
DLEDKEGEIQ AGAKLSLNRQ FFDERWSKHR VVSCLDWSSQ YPELLVASYN
310 320 330 340 350
NNEDAPHEPD GVALVWNMKY KKTTPEYVFH CQSAVMSATF AKFHPNLVVG
360 370 380 390 400
GTYSGQIVLW DNRSNKRTPV QRTPLSAAAH THPVYCVNVV GTQNAHNLIS
410 420 430 440 450
ISTDGKICSW SLDMLSHPQD SMELVHKQSK AVAVTSMSFP VGDVNNFVVG
460 470 480 490 500
SEEGSVYTAC RHGSKAGISE MFEGHQGPIT GIHCHAAVGA VDFSHLFVTS
510 520 530 540 550
SFDWTVKLWT TKNNKPLYSF EDNADYVYDV MWSPTHPALF ACVDGMGRLD
560 570 580 590 600
LWNLNNDTEV PTASISVEGN PALNRVRWTH SGREIAVGDS EGQIVIYDVG
610 620 630
EQIAVPRNDE WARFGRTLAE INANRADAEE EAATRIPA
Length:638
Mass (Da):71,457
Last modified:September 19, 2002 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2F868EC9556C47F2
GO
Isoform 2B (identifier: Q13409-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     77-82: Missing.

Show »
Length:632
Mass (Da):70,645
Checksum:i5E643B54A2979294
GO
Isoform 2C (identifier: Q13409-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     77-82: Missing.
     113-132: Missing.

Show »
Length:612
Mass (Da):68,426
Checksum:i518E1D765A2CBB15
GO
Isoform 2E (identifier: Q13409-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     602-602: Missing.

Show »
Length:637
Mass (Da):71,328
Checksum:i0526BC20523DF804
GO
Isoform 2F (identifier: Q13409-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     77-82: Missing.
     113-132: Missing.
     602-602: Missing.

Show »
Length:611
Mass (Da):68,298
Checksum:i9DB5032F12C11F5B
GO
Isoform 3 (identifier: Q13409-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     76-81: VFSEYW → AEQPLRVVTADTCLFHYL
     113-132: Missing.

Show »
Length:630
Mass (Da):70,485
Checksum:i5C3022F6F62D9C67
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 12 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E7EMU4E7EMU4_HUMAN
Cytoplasmic dynein 1 intermediate c...
DYNC1I2
214Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7EQU2E7EQU2_HUMAN
Cytoplasmic dynein 1 intermediate c...
DYNC1I2
185Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7EQL5E7EQL5_HUMAN
Cytoplasmic dynein 1 intermediate c...
DYNC1I2
305Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7ESD3E7ESD3_HUMAN
Cytoplasmic dynein 1 intermediate c...
DYNC1I2
187Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7ETL8E7ETL8_HUMAN
Cytoplasmic dynein 1 intermediate c...
DYNC1I2
184Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7ET01E7ET01_HUMAN
Cytoplasmic dynein 1 intermediate c...
DYNC1I2
173Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7EV09E7EV09_HUMAN
Cytoplasmic dynein 1 intermediate c...
DYNC1I2
250Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PGG1E9PGG1_HUMAN
Cytoplasmic dynein 1 intermediate c...
DYNC1I2
110Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7ERH4E7ERH4_HUMAN
Cytoplasmic dynein 1 intermediate c...
DYNC1I2
151Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7ERR6E7ERR6_HUMAN
Cytoplasmic dynein 1 intermediate c...
DYNC1I2
139Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAA89166 differs from that shown. Unlikely isoform. Several sequence problems.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti510T → S in AAP97254 (Ref. 1) Curated1
Sequence conflicti525D → G in AAP97254 (Ref. 1) Curated1
Sequence conflicti572A → G in AAI09376 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_082947247Y → C in NEDMIBA; loss-of-function variant; does not rescue neurodevelopmental defects in zebrafish morphants. 1 Publication1
Natural variantiVAR_082948290 – 638Missing in NEDMIBA; loss-of-function variant; does not rescue neurodevelopmental defects in zebrafish morphants. 1 PublicationAdd BLAST349
Natural variantiVAR_082949516P → A Likely benign variant; can rescue neurodevelopmental defects in zebrafish morphants. 1 PublicationCorresponds to variant dbSNP:rs767705533Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_05437776 – 81VFSEYW → AEQPLRVVTADTCLFHYL in isoform 3. 1 Publication6
Alternative sequenceiVSP_00133677 – 82Missing in isoform 2B, isoform 2C and isoform 2F. 5 Publications6
Alternative sequenceiVSP_001337113 – 132Missing in isoform 2C, isoform 2F and isoform 3. 6 PublicationsAdd BLAST20
Alternative sequenceiVSP_023011602Missing in isoform 2E and isoform 2F. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF134477 mRNA Translation: AAP97254.1
AF250307 mRNA Translation: AAK37426.1
AY037160 mRNA Translation: AAK67638.1
BT007130 mRNA Translation: AAP35794.1
AK055491 mRNA Translation: BAB70932.1
AK316119 mRNA Translation: BAH14490.1
AL137519 mRNA Translation: CAB70785.1
BX537412 mRNA Translation: CAD97654.1
AC064826 Genomic DNA No translation available.
AC068039 Genomic DNA Translation: AAY24133.1
CH471058 Genomic DNA Translation: EAX11202.1
CH471058 Genomic DNA Translation: EAX11204.1
CH471058 Genomic DNA Translation: EAX11206.1
CH471058 Genomic DNA Translation: EAX11207.1
CH471058 Genomic DNA Translation: EAX11208.1
CH471058 Genomic DNA Translation: EAX11209.1
BC091498 mRNA Translation: AAH91498.1
BC109375 mRNA Translation: AAI09376.1
BC015038 mRNA Translation: AAH15038.1
U39575 mRNA Translation: AAA89166.1 Sequence problems.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS46450.1 [Q13409-1]
CCDS63054.1 [Q13409-7]
CCDS63056.1 [Q13409-3]
CCDS63057.1 [Q13409-6]
CCDS82533.1 [Q13409-2]

Protein sequence database of the Protein Information Resource

More...
PIRi
T46365

NCBI Reference Sequences

More...
RefSeqi
NP_001258714.1, NM_001271785.1 [Q13409-1]
NP_001258715.1, NM_001271786.1 [Q13409-7]
NP_001258716.1, NM_001271787.1 [Q13409-7]
NP_001258717.1, NM_001271788.1 [Q13409-3]
NP_001258718.1, NM_001271789.1 [Q13409-3]
NP_001258719.1, NM_001271790.1 [Q13409-6]
NP_001307811.1, NM_001320882.1 [Q13409-2]
NP_001307812.1, NM_001320883.1 [Q13409-2]
NP_001307813.1, NM_001320884.1 [Q13409-6]
NP_001369.1, NM_001378.2 [Q13409-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000340296; ENSP00000339430; ENSG00000077380 [Q13409-3]
ENST00000397119; ENSP00000380308; ENSG00000077380 [Q13409-1]
ENST00000409197; ENSP00000386397; ENSG00000077380 [Q13409-3]
ENST00000409317; ENSP00000386591; ENSG00000077380 [Q13409-2]
ENST00000409453; ENSP00000386886; ENSG00000077380 [Q13409-5]
ENST00000409773; ENSP00000386415; ENSG00000077380 [Q13409-1]
ENST00000410079; ENSP00000386522; ENSG00000077380 [Q13409-7]
ENST00000508530; ENSP00000423339; ENSG00000077380 [Q13409-6]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
1781

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:1781

UCSC genome browser

More...
UCSCi
uc002uha.3, human [Q13409-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF134477 mRNA Translation: AAP97254.1
AF250307 mRNA Translation: AAK37426.1
AY037160 mRNA Translation: AAK67638.1
BT007130 mRNA Translation: AAP35794.1
AK055491 mRNA Translation: BAB70932.1
AK316119 mRNA Translation: BAH14490.1
AL137519 mRNA Translation: CAB70785.1
BX537412 mRNA Translation: CAD97654.1
AC064826 Genomic DNA No translation available.
AC068039 Genomic DNA Translation: AAY24133.1
CH471058 Genomic DNA Translation: EAX11202.1
CH471058 Genomic DNA Translation: EAX11204.1
CH471058 Genomic DNA Translation: EAX11206.1
CH471058 Genomic DNA Translation: EAX11207.1
CH471058 Genomic DNA Translation: EAX11208.1
CH471058 Genomic DNA Translation: EAX11209.1
BC091498 mRNA Translation: AAH91498.1
BC109375 mRNA Translation: AAI09376.1
BC015038 mRNA Translation: AAH15038.1
U39575 mRNA Translation: AAA89166.1 Sequence problems.
CCDSiCCDS46450.1 [Q13409-1]
CCDS63054.1 [Q13409-7]
CCDS63056.1 [Q13409-3]
CCDS63057.1 [Q13409-6]
CCDS82533.1 [Q13409-2]
PIRiT46365
RefSeqiNP_001258714.1, NM_001271785.1 [Q13409-1]
NP_001258715.1, NM_001271786.1 [Q13409-7]
NP_001258716.1, NM_001271787.1 [Q13409-7]
NP_001258717.1, NM_001271788.1 [Q13409-3]
NP_001258718.1, NM_001271789.1 [Q13409-3]
NP_001258719.1, NM_001271790.1 [Q13409-6]
NP_001307811.1, NM_001320882.1 [Q13409-2]
NP_001307812.1, NM_001320883.1 [Q13409-2]
NP_001307813.1, NM_001320884.1 [Q13409-6]
NP_001369.1, NM_001378.2 [Q13409-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5JPWNMR-A/B134-154[»]
6F1Telectron microscopy3.50g/h/o/p1-638[»]
6F1Uelectron microscopy3.40h1-638[»]
6F1Zelectron microscopy3.40o/p1-638[»]
6F38electron microscopy6.70g/h/o/p1-638[»]
6F3Aelectron microscopy8.20g/h1-638[»]
SMRiQ13409
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi108119, 188 interactors
ELMiQ13409
IntActiQ13409, 38 interactors
MINTiQ13409
STRINGi9606.ENSP00000380308

Chemistry databases

ChEMBLiCHEMBL4295815

PTM databases

iPTMnetiQ13409
PhosphoSitePlusiQ13409
SwissPalmiQ13409

Polymorphism and mutation databases

BioMutaiDYNC1I2
DMDMi23503058

2D gel databases

REPRODUCTION-2DPAGEiIPI00827813

Proteomic databases

EPDiQ13409
jPOSTiQ13409
MassIVEiQ13409
MaxQBiQ13409
PaxDbiQ13409
PeptideAtlasiQ13409
PRIDEiQ13409
ProteomicsDBi59388 [Q13409-1]
59389 [Q13409-2]
59390 [Q13409-3]
59391 [Q13409-5]
59392 [Q13409-6]
7048

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
33847, 135 antibodies

The DNASU plasmid repository

More...
DNASUi
1781

Genome annotation databases

EnsembliENST00000340296; ENSP00000339430; ENSG00000077380 [Q13409-3]
ENST00000397119; ENSP00000380308; ENSG00000077380 [Q13409-1]
ENST00000409197; ENSP00000386397; ENSG00000077380 [Q13409-3]
ENST00000409317; ENSP00000386591; ENSG00000077380 [Q13409-2]
ENST00000409453; ENSP00000386886; ENSG00000077380 [Q13409-5]
ENST00000409773; ENSP00000386415; ENSG00000077380 [Q13409-1]
ENST00000410079; ENSP00000386522; ENSG00000077380 [Q13409-7]
ENST00000508530; ENSP00000423339; ENSG00000077380 [Q13409-6]
GeneIDi1781
KEGGihsa:1781
UCSCiuc002uha.3, human [Q13409-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
1781
DisGeNETi1781
EuPathDBiHostDB:ENSG00000077380.15

GeneCards: human genes, protein and diseases

More...
GeneCardsi
DYNC1I2
HGNCiHGNC:2964, DYNC1I2
HPAiENSG00000077380, Low tissue specificity
MalaCardsiDYNC1I2
MIMi603331, gene
618492, phenotype
neXtProtiNX_Q13409
OpenTargetsiENSG00000077380
PharmGKBiPA27435

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1587, Eukaryota
GeneTreeiENSGT00940000155442
HOGENOMiCLU_012999_1_1_1
InParanoidiQ13409
KOiK10415
OMAiTAKFSPY
PhylomeDBiQ13409
TreeFamiTF300553

Enzyme and pathway databases

PathwayCommonsiQ13409
ReactomeiR-HSA-141444, Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
R-HSA-2132295, MHC class II antigen presentation
R-HSA-2467813, Separation of Sister Chromatids
R-HSA-2500257, Resolution of Sister Chromatid Cohesion
R-HSA-2565942, Regulation of PLK1 Activity at G2/M Transition
R-HSA-3371497, HSP90 chaperone cycle for steroid hormone receptors (SHR)
R-HSA-380259, Loss of Nlp from mitotic centrosomes
R-HSA-380270, Recruitment of mitotic centrosome proteins and complexes
R-HSA-380284, Loss of proteins required for interphase microtubule organization from the centrosome
R-HSA-380320, Recruitment of NuMA to mitotic centrosomes
R-HSA-5620912, Anchoring of the basal body to the plasma membrane
R-HSA-5663220, RHO GTPases Activate Formins
R-HSA-6807878, COPI-mediated anterograde transport
R-HSA-6811436, COPI-independent Golgi-to-ER retrograde traffic
R-HSA-68877, Mitotic Prometaphase
R-HSA-8854518, AURKA Activation by TPX2
R-HSA-9609690, HCMV Early Events
R-HSA-9646399, Aggrephagy
R-HSA-9648025, EML4 and NUDC in mitotic spindle formation
SignaLinkiQ13409

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
1781, 726 hits in 877 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
DYNC1I2, human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
DYNC1I2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
1781
PharosiQ13409, Tbio

Protein Ontology

More...
PROi
PR:Q13409
RNActiQ13409, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000077380, Expressed in brain and 116 other tissues
ExpressionAtlasiQ13409, baseline and differential
GenevisibleiQ13409, HS

Family and domain databases

Gene3Di2.130.10.10, 2 hits
InterProiView protein in InterPro
IPR025956, DYNC1I1/DYNC1I2
IPR015943, WD40/YVTN_repeat-like_dom_sf
IPR001680, WD40_repeat
IPR017986, WD40_repeat_dom
IPR036322, WD40_repeat_dom_sf
PfamiView protein in Pfam
PF11540, Dynein_IC2, 1 hit
PF00400, WD40, 1 hit
SMARTiView protein in SMART
SM00320, WD40, 5 hits
SUPFAMiSSF50978, SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS50294, WD_REPEATS_REGION, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDC1I2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q13409
Secondary accession number(s): B7ZA04
, D3DPD4, D3DPD5, D3DPD6, Q32LY9, Q53S84, Q5BJF8, Q7Z4X1, Q96NG7, Q96S87, Q9BXZ5, Q9NT58
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: September 19, 2002
Last modified: October 7, 2020
This is version 206 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families
  5. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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