Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

39S ribosomal protein L49, mitochondrial

Gene

MRPL49

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • structural constituent of ribosome Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-HSA-5368286 Mitochondrial translation initiation
R-HSA-5389840 Mitochondrial translation elongation
R-HSA-5419276 Mitochondrial translation termination

Names & Taxonomyi

Protein namesi
Recommended name:
39S ribosomal protein L49, mitochondrial
Short name:
L49mt
Short name:
MRP-L49
Alternative name(s):
Mitochondrial large ribosomal subunit protein mL491 Publication
Neighbor of FAU
Short name:
NOF
Protein NOF1
Gene namesi
Name:MRPL49
Synonyms:C11orf4, NOF1
ORF Names:OK/SW-cl.67
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000149792.8
HGNCiHGNC:1176 MRPL49
MIMi606866 gene
neXtProtiNX_Q13405

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

DisGeNETi740
OpenTargetsiENSG00000149792
PharmGKBiPA30981

Polymorphism and mutation databases

BioMutaiMRPL49

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002076641 – 16639S ribosomal protein L49, mitochondrialAdd BLAST166

Proteomic databases

EPDiQ13405
MaxQBiQ13405
PaxDbiQ13405
PeptideAtlasiQ13405
PRIDEiQ13405
ProteomicsDBi59387
TopDownProteomicsiQ13405

PTM databases

iPTMnetiQ13405
PhosphoSitePlusiQ13405

Expressioni

Tissue specificityi

Ubiquitous.

Gene expression databases

BgeeiENSG00000149792 Expressed in 232 organ(s), highest expression level in right adrenal gland
CleanExiHS_MRPL49
ExpressionAtlasiQ13405 baseline and differential
GenevisibleiQ13405 HS

Organism-specific databases

HPAiHPA046778

Interactioni

Subunit structurei

Component of the mitochondrial large ribosomal subunit (mt-LSU) (PubMed:28892042, PubMed:25838379, PubMed:25278503). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins (PubMed:11551941, PubMed:25278503, PubMed:25838379). Interacts with OXA1L (By similarity).By similarity4 Publications

Protein-protein interaction databases

BioGridi107199, 56 interactors
CORUMiQ13405
IntActiQ13405, 19 interactors
MINTiQ13405
STRINGi9606.ENSP00000279242

Structurei

Secondary structure

1166
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ13405
SMRiQ13405
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG4034 Eukaryota
ENOG4111N34 LUCA
GeneTreeiENSGT00390000017253
HOGENOMiHOG000044600
HOVERGENiHBG023124
InParanoidiQ13405
KOiK17430
OMAiYPSGWKP
OrthoDBiEOG091G1549
PhylomeDBiQ13405
TreeFamiTF317750

Family and domain databases

InterProiView protein in InterPro
IPR007740 Ribosomal_L49/IMG2
PANTHERiPTHR13477 PTHR13477, 1 hit
PfamiView protein in Pfam
PF05046 Img2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

Q13405-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAATMFRATL RGWRTGVQRG CGLRLLSQTQ GPPDYPRFVE SVDEYQFVER
60 70 80 90 100
LLPATRIPDP PKHEHYPTPS GWQPPRDPPP NLPYFVRRSR MHNIPVYKDI
110 120 130 140 150
THGNRQMTVI RKVEGDIWAL QKDVEDFLSP LLGKTPVTQV NEVTGTLRIK
160
GYFDQELKAW LLEKGF
Length:166
Mass (Da):19,198
Last modified:November 1, 1996 - v1
Checksum:i66AB18FDE25D92B4
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PNF1E9PNF1_HUMAN
39S ribosomal protein L49, mitochon...
MRPL49
140Annotation score:
H0YDP7H0YDP7_HUMAN
39S ribosomal protein L49, mitochon...
MRPL49
127Annotation score:
E9PI78E9PI78_HUMAN
39S ribosomal protein L49, mitochon...
MRPL49
99Annotation score:
E9PRD2E9PRD2_HUMAN
39S ribosomal protein L49, mitochon...
MRPL49
56Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0219919T → A. Corresponds to variant dbSNP:rs17146691Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U39400 mRNA Translation: AAB18826.1
AB062395 mRNA Translation: BAB93482.1
AK311821 mRNA Translation: BAG34763.1
CH471076 Genomic DNA Translation: EAW74355.1
BC004378 mRNA Translation: AAH04378.1
CCDSiCCDS8096.1
PIRiG02237
RefSeqiNP_004918.1, NM_004927.3
UniGeneiHs.744882

Genome annotation databases

EnsembliENST00000279242; ENSP00000279242; ENSG00000149792
ENST00000526319; ENSP00000434190; ENSG00000149792
GeneIDi740
KEGGihsa:740
UCSCiuc001oda.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U39400 mRNA Translation: AAB18826.1
AB062395 mRNA Translation: BAB93482.1
AK311821 mRNA Translation: BAG34763.1
CH471076 Genomic DNA Translation: EAW74355.1
BC004378 mRNA Translation: AAH04378.1
CCDSiCCDS8096.1
PIRiG02237
RefSeqiNP_004918.1, NM_004927.3
UniGeneiHs.744882

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3J7Yelectron microscopy3.40g1-166[»]
3J9Melectron microscopy3.50g1-166[»]
5OOLelectron microscopy3.06g1-166[»]
5OOMelectron microscopy3.03g1-166[»]
ProteinModelPortaliQ13405
SMRiQ13405
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107199, 56 interactors
CORUMiQ13405
IntActiQ13405, 19 interactors
MINTiQ13405
STRINGi9606.ENSP00000279242

PTM databases

iPTMnetiQ13405
PhosphoSitePlusiQ13405

Polymorphism and mutation databases

BioMutaiMRPL49

Proteomic databases

EPDiQ13405
MaxQBiQ13405
PaxDbiQ13405
PeptideAtlasiQ13405
PRIDEiQ13405
ProteomicsDBi59387
TopDownProteomicsiQ13405

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000279242; ENSP00000279242; ENSG00000149792
ENST00000526319; ENSP00000434190; ENSG00000149792
GeneIDi740
KEGGihsa:740
UCSCiuc001oda.3 human

Organism-specific databases

CTDi740
DisGeNETi740
EuPathDBiHostDB:ENSG00000149792.8
GeneCardsiMRPL49
HGNCiHGNC:1176 MRPL49
HPAiHPA046778
MIMi606866 gene
neXtProtiNX_Q13405
OpenTargetsiENSG00000149792
PharmGKBiPA30981
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4034 Eukaryota
ENOG4111N34 LUCA
GeneTreeiENSGT00390000017253
HOGENOMiHOG000044600
HOVERGENiHBG023124
InParanoidiQ13405
KOiK17430
OMAiYPSGWKP
OrthoDBiEOG091G1549
PhylomeDBiQ13405
TreeFamiTF317750

Enzyme and pathway databases

ReactomeiR-HSA-5368286 Mitochondrial translation initiation
R-HSA-5389840 Mitochondrial translation elongation
R-HSA-5419276 Mitochondrial translation termination

Miscellaneous databases

ChiTaRSiMRPL49 human
GenomeRNAii740
PROiPR:Q13405
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000149792 Expressed in 232 organ(s), highest expression level in right adrenal gland
CleanExiHS_MRPL49
ExpressionAtlasiQ13405 baseline and differential
GenevisibleiQ13405 HS

Family and domain databases

InterProiView protein in InterPro
IPR007740 Ribosomal_L49/IMG2
PANTHERiPTHR13477 PTHR13477, 1 hit
PfamiView protein in Pfam
PF05046 Img2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRM49_HUMAN
AccessioniPrimary (citable) accession number: Q13405
Secondary accession number(s): B2R4G6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 1, 1996
Last modified: November 7, 2018
This is version 150 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Ribosomal proteins
    Ribosomal proteins families and list of entries
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again