UniProtKB - Q13405 (RM49_HUMAN)
39S ribosomal protein L49, mitochondrial
MRPL49
Functioni
GO - Molecular functioni
- structural constituent of ribosome Source: GO_Central
GO - Biological processi
- mitochondrial translational elongation Source: Reactome
- mitochondrial translational termination Source: Reactome
Keywordsi
Molecular function | Ribonucleoprotein, Ribosomal protein |
Enzyme and pathway databases
PathwayCommonsi | Q13405 |
Reactomei | R-HSA-5368286, Mitochondrial translation initiation R-HSA-5389840, Mitochondrial translation elongation R-HSA-5419276, Mitochondrial translation termination |
SIGNORi | Q13405 |
Names & Taxonomyi
Protein namesi | Recommended name: 39S ribosomal protein L49, mitochondrialShort name: L49mt Short name: MRP-L49 Alternative name(s): Mitochondrial large ribosomal subunit protein mL491 Publication Neighbor of FAU Short name: NOF Protein NOF1 |
Gene namesi | Name:MRPL49 Synonyms:C11orf4, NOF1 ORF Names:OK/SW-cl.67 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:1176, MRPL49 |
MIMi | 606866, gene |
neXtProti | NX_Q13405 |
VEuPathDBi | HostDB:ENSG00000149792.8 |
Subcellular locationi
Mitochondrion
- Mitochondrion 3 Publications
Mitochondrion
- mitochondrial inner membrane Source: Reactome
- mitochondrial large ribosomal subunit Source: UniProtKB
- mitochondrial ribosome Source: UniProtKB
- mitochondrion Source: UniProtKB
Keywords - Cellular componenti
MitochondrionPathology & Biotechi
Organism-specific databases
DisGeNETi | 740 |
OpenTargetsi | ENSG00000149792 |
PharmGKBi | PA30981 |
Miscellaneous databases
Pharosi | Q13405, Tbio |
Genetic variation databases
BioMutai | MRPL49 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000207664 | 1 – 166 | 39S ribosomal protein L49, mitochondrialAdd BLAST | 166 |
Proteomic databases
EPDi | Q13405 |
jPOSTi | Q13405 |
MassIVEi | Q13405 |
MaxQBi | Q13405 |
PaxDbi | Q13405 |
PeptideAtlasi | Q13405 |
PRIDEi | Q13405 |
ProteomicsDBi | 59387 |
TopDownProteomicsi | Q13405 |
PTM databases
iPTMneti | Q13405 |
PhosphoSitePlusi | Q13405 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000149792, Expressed in right adrenal gland and 242 other tissues |
ExpressionAtlasi | Q13405, baseline and differential |
Genevisiblei | Q13405, HS |
Organism-specific databases
HPAi | ENSG00000149792, Low tissue specificity |
Interactioni
Subunit structurei
Component of the mitochondrial large ribosomal subunit (mt-LSU) (PubMed:28892042, PubMed:25838379, PubMed:25278503). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins (PubMed:11551941, PubMed:25278503, PubMed:25838379).
Interacts with OXA1L (By similarity).
By similarity4 PublicationsBinary interactionsi
Hide detailsQ13405
With | #Exp. | IntAct |
---|---|---|
ATN1 [Q86V38] | 3 | EBI-5325200,EBI-11954292 |
BDNF - isoform 2 [P23560-2] | 3 | EBI-5325200,EBI-12275524 |
JPH3 [Q8WXH2] | 3 | EBI-5325200,EBI-1055254 |
PECAM1 [P16284] | 3 | EBI-5325200,EBI-716404 |
Protein-protein interaction databases
BioGRIDi | 107199, 127 interactors |
ComplexPortali | CPX-5226, 39S mitochondrial large ribosomal subunit |
CORUMi | Q13405 |
IntActi | Q13405, 49 interactors |
MINTi | Q13405 |
STRINGi | 9606.ENSP00000279242 |
Miscellaneous databases
RNActi | Q13405, protein |
Structurei
Secondary structure
3D structure databases
SMRi | Q13405 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG4034, Eukaryota |
GeneTreei | ENSGT00390000017253 |
HOGENOMi | CLU_085757_2_3_1 |
InParanoidi | Q13405 |
OMAi | YPSGWKP |
OrthoDBi | 1534017at2759 |
PhylomeDBi | Q13405 |
TreeFami | TF317750 |
Family and domain databases
InterProi | View protein in InterPro IPR007740, Ribosomal_L49/IMG2 |
PANTHERi | PTHR13477, PTHR13477, 1 hit |
Pfami | View protein in Pfam PF05046, Img2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All
10 20 30 40 50
MAATMFRATL RGWRTGVQRG CGLRLLSQTQ GPPDYPRFVE SVDEYQFVER
60 70 80 90 100
LLPATRIPDP PKHEHYPTPS GWQPPRDPPP NLPYFVRRSR MHNIPVYKDI
110 120 130 140 150
THGNRQMTVI RKVEGDIWAL QKDVEDFLSP LLGKTPVTQV NEVTGTLRIK
160
GYFDQELKAW LLEKGF
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketE9PNF1 | E9PNF1_HUMAN | 39S ribosomal protein L49, mitochon... | MRPL49 | 140 | Annotation score: | ||
H0YDP7 | H0YDP7_HUMAN | 39S ribosomal protein L49, mitochon... | MRPL49 | 127 | Annotation score: | ||
E9PI78 | E9PI78_HUMAN | 39S ribosomal protein L49, mitochon... | MRPL49 | 99 | Annotation score: | ||
E9PRD2 | E9PRD2_HUMAN | 39S ribosomal protein L49, mitochon... | MRPL49 | 56 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_021991 | 9 | T → A. Corresponds to variant dbSNP:rs17146691Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U39400 mRNA Translation: AAB18826.1 AB062395 mRNA Translation: BAB93482.1 AK311821 mRNA Translation: BAG34763.1 CH471076 Genomic DNA Translation: EAW74355.1 BC004378 mRNA Translation: AAH04378.1 |
CCDSi | CCDS8096.1 |
PIRi | G02237 |
RefSeqi | NP_004918.1, NM_004927.3 |
Genome annotation databases
Ensembli | ENST00000279242; ENSP00000279242; ENSG00000149792 ENST00000526319; ENSP00000434190; ENSG00000149792 |
GeneIDi | 740 |
KEGGi | hsa:740 |
UCSCi | uc001oda.3, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U39400 mRNA Translation: AAB18826.1 AB062395 mRNA Translation: BAB93482.1 AK311821 mRNA Translation: BAG34763.1 CH471076 Genomic DNA Translation: EAW74355.1 BC004378 mRNA Translation: AAH04378.1 |
CCDSi | CCDS8096.1 |
PIRi | G02237 |
RefSeqi | NP_004918.1, NM_004927.3 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
3J7Y | electron microscopy | 3.40 | g | 1-166 | [»] | |
3J9M | electron microscopy | 3.50 | g | 1-166 | [»] | |
5OOL | electron microscopy | 3.06 | g | 1-166 | [»] | |
5OOM | electron microscopy | 3.03 | g | 1-166 | [»] | |
6I9R | electron microscopy | 3.90 | g | 1-166 | [»] | |
6NU2 | electron microscopy | 3.90 | g | 38-166 | [»] | |
6NU3 | electron microscopy | 4.40 | g | 1-166 | [»] | |
6VLZ | electron microscopy | 2.97 | g | 1-166 | [»] | |
6VMI | electron microscopy | 2.96 | g | 1-166 | [»] | |
6ZM5 | electron microscopy | 2.89 | g | 1-166 | [»] | |
6ZM6 | electron microscopy | 2.59 | g | 1-166 | [»] | |
6ZS9 | electron microscopy | 4.00 | g | 1-166 | [»] | |
6ZSA | electron microscopy | 4.00 | g | 1-166 | [»] | |
6ZSB | electron microscopy | 4.50 | g | 1-166 | [»] | |
6ZSC | electron microscopy | 3.50 | g | 1-166 | [»] | |
6ZSD | electron microscopy | 3.70 | g | 1-166 | [»] | |
6ZSE | electron microscopy | 5.00 | g | 1-166 | [»] | |
6ZSG | electron microscopy | 4.00 | g | 1-166 | [»] | |
7A5F | electron microscopy | 4.40 | g3 | 1-166 | [»] | |
7A5G | electron microscopy | 4.33 | g3 | 1-166 | [»] | |
7A5H | electron microscopy | 3.30 | g | 1-166 | [»] | |
7A5I | electron microscopy | 3.70 | g3 | 1-166 | [»] | |
7A5J | electron microscopy | 3.10 | g | 1-166 | [»] | |
7A5K | electron microscopy | 3.70 | g3 | 1-166 | [»] | |
SMRi | Q13405 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 107199, 127 interactors |
ComplexPortali | CPX-5226, 39S mitochondrial large ribosomal subunit |
CORUMi | Q13405 |
IntActi | Q13405, 49 interactors |
MINTi | Q13405 |
STRINGi | 9606.ENSP00000279242 |
PTM databases
iPTMneti | Q13405 |
PhosphoSitePlusi | Q13405 |
Genetic variation databases
BioMutai | MRPL49 |
Proteomic databases
EPDi | Q13405 |
jPOSTi | Q13405 |
MassIVEi | Q13405 |
MaxQBi | Q13405 |
PaxDbi | Q13405 |
PeptideAtlasi | Q13405 |
PRIDEi | Q13405 |
ProteomicsDBi | 59387 |
TopDownProteomicsi | Q13405 |
Protocols and materials databases
Antibodypediai | 29687, 119 antibodies |
Genome annotation databases
Ensembli | ENST00000279242; ENSP00000279242; ENSG00000149792 ENST00000526319; ENSP00000434190; ENSG00000149792 |
GeneIDi | 740 |
KEGGi | hsa:740 |
UCSCi | uc001oda.3, human |
Organism-specific databases
CTDi | 740 |
DisGeNETi | 740 |
GeneCardsi | MRPL49 |
HGNCi | HGNC:1176, MRPL49 |
HPAi | ENSG00000149792, Low tissue specificity |
MIMi | 606866, gene |
neXtProti | NX_Q13405 |
OpenTargetsi | ENSG00000149792 |
PharmGKBi | PA30981 |
VEuPathDBi | HostDB:ENSG00000149792.8 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG4034, Eukaryota |
GeneTreei | ENSGT00390000017253 |
HOGENOMi | CLU_085757_2_3_1 |
InParanoidi | Q13405 |
OMAi | YPSGWKP |
OrthoDBi | 1534017at2759 |
PhylomeDBi | Q13405 |
TreeFami | TF317750 |
Enzyme and pathway databases
PathwayCommonsi | Q13405 |
Reactomei | R-HSA-5368286, Mitochondrial translation initiation R-HSA-5389840, Mitochondrial translation elongation R-HSA-5419276, Mitochondrial translation termination |
SIGNORi | Q13405 |
Miscellaneous databases
BioGRID-ORCSi | 740, 405 hits in 998 CRISPR screens |
ChiTaRSi | MRPL49, human |
GenomeRNAii | 740 |
Pharosi | Q13405, Tbio |
PROi | PR:Q13405 |
RNActi | Q13405, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000149792, Expressed in right adrenal gland and 242 other tissues |
ExpressionAtlasi | Q13405, baseline and differential |
Genevisiblei | Q13405, HS |
Family and domain databases
InterProi | View protein in InterPro IPR007740, Ribosomal_L49/IMG2 |
PANTHERi | PTHR13477, PTHR13477, 1 hit |
Pfami | View protein in Pfam PF05046, Img2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | RM49_HUMAN | |
Accessioni | Q13405Primary (citable) accession number: Q13405 Secondary accession number(s): B2R4G6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 15, 1999 |
Last sequence update: | November 1, 1996 | |
Last modified: | April 7, 2021 | |
This is version 167 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Ribosomal proteins
Ribosomal proteins families and list of entries - Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families