UBE2V1

Functionⁱ

Has no ubiquitin ligase activity on its own. The UBE2V1-UBE2N heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through Lys-63. This type of poly-ubiquitination activates IKK and does not seem to involve protein degradation by the proteasome. Plays a role in the activation of NF-kappa-B mediated by IL1B, TNF, TRAF6 and TRAF2. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage. Promotes TRIM5 capsid-specific restriction activity and the UBE2V1-UBE2N heterodimer acts in concert with TRIM5 to generate 'Lys-63'-linked polyubiquitin chains which activate the MAP3K7/TAK1 complex which in turn results in the induction and expression of NF-kappa-B and MAPK-responsive inflammatory genes.7 Publications

Miscellaneous

In human, TMEM189/KUA and UBE2V1/UEV1 are adjacent genes which can produce independent proteins and can also be fused to form a TMEM189-UBE2V1 hybrid protein.

GO - Molecular functionⁱ

ubiquitin conjugating enzyme activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

activation of MAPK activity Source: Reactome
cell differentiation
Source: UniProtKB
Non-traceable author statementⁱ
- 9418904
interleukin-1-mediated signaling pathway Source: Reactome
JNK cascade Source: Reactome
nucleotide-binding oligomerization domain containing signaling pathway Source: Reactome
positive regulation of I-kappaB kinase/NF-kappaB signaling
Source: HGNC
Inferred from mutant phenotypeⁱ
- 16129784
positive regulation of NF-kappaB transcription factor activity
Source: HGNC
Inferred from mutant phenotypeⁱ
- 16129784
positive regulation of transcription, DNA-templated
Source: UniProtKB
Traceable author statementⁱ
- 9305758
postreplication repair
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
protein K63-linked ubiquitination
Source: UniProtKB
Inferred from direct assayⁱ
- 16307917
- 21512573
protein polyubiquitination
Source: ProtInc
Traceable author statementⁱ
- 10089880
regulation of DNA repair
Source: ProtInc
Traceable author statementⁱ
- 10089880
regulation of transcription, DNA-templated
Source: UniProtKB
Traceable author statementⁱ
- 9305758

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Ubl conjugation pathway

Biological process

Ubl conjugation pathway

Enzyme and pathway databases

BRENDAⁱ	2.3.2.B6 2681
Reactomeⁱ	R-HSA-168638 NOD1/2 Signaling Pathway R-HSA-168927 TICAM1, RIP1-mediated IKK complex recruitment R-HSA-202424 Downstream TCR signaling R-HSA-2871837 FCERI mediated NF-kB activation R-HSA-445989 TAK1 activates NFkB by phosphorylation and activation of IKKs complex R-HSA-450302 activated TAK1 mediates p38 MAPK activation R-HSA-450321 JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-5607764 CLEC7A (Dectin-1) signaling R-HSA-9020702 Interleukin-1 signaling R-HSA-937039 IRAK1 recruits IKK complex R-HSA-937041 IKK complex recruitment mediated by RIP1 R-HSA-975110 TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling R-HSA-975144 IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation
SignaLinkⁱ	Q13404
SIGNORⁱ	Q13404

Protein family/group databases

MoonDBⁱ	Q13404 Predicted

MoonDBⁱ

Q13404 Predicted

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Ubiquitin-conjugating enzyme E2 variant 1 Short name: UEV-1 Alternative name(s): CROC-1 TRAF6-regulated IKK activator 1 beta Uev1A
Gene namesⁱ	Name:UBE2V1 Synonyms:CROC1, UBE2V, UEV1 ORF Names:P/OKcl.19
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 20

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000244687.11
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:12494 UBE2V1
MIMⁱ	602995 gene
neXtProtⁱ	NX_Q13404

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	387521 387522 7335
Open Targets More...OpenTargetsⁱ	ENSG00000244687
PharmGKBⁱ	PA37142

Polymorphism and mutation databases

BioMutaⁱ	UBE2V1
DMDMⁱ	259016163

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Initiator methionineⁱ		RemovedCombined sources1 Publication
ChainⁱPRO_0000082600	2 – 147	Ubiquitin-conjugating enzyme E2 variant 1Add BLAST		146

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	2	N-acetylalanineCombined sources1 Publication		1

Keywords - PTMⁱ

Acetylation

Proteomic databases

EPDⁱ	Q13404
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q13404
PaxDbⁱ	Q13404
PeptideAtlas More...PeptideAtlasⁱ	Q13404
PRIDEⁱ	Q13404
ProteomicsDBⁱ	59382 59383 [Q13404-1] 59384 [Q13404-2] 59385 [Q13404-6] 59386 [Q13404-7]
TopDownProteomicsⁱ	Q13404-4 [Q13404-4]

PTM databases

iPTMnetⁱ	Q13404
PhosphoSitePlusⁱ	Q13404
SwissPalmⁱ	Q13404

Expressionⁱ

Tissue specificityⁱ

Highly expressed in thyroid, pancreas, spinal cord, lymph node, trachea, adrenal gland, bone marrow and pancreas. Detected at low levels in heart, breast, placenta, brain, liver, kidney, stomach and lung.2 Publications

Inductionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000244687 Expressed in 94 organ(s), highest expression level in frontal cortex
ExpressionAtlasⁱ	Q13404 baseline and differential
Genevisibleⁱ	Q13404 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA052535 HPA053186

HPAⁱ

HPA052535
HPA053186

Interactionⁱ

Subunit structureⁱ

Heterodimer with UBE2N (PubMed:11057907, PubMed:16307917, PubMed:16893187). Interacts (UBE2V2-UBE2N heterodimer) with the E3 ligase STUB1 (via the U-box domain); the complex has a specific 'Lys-63'-linked polyubiquitination activity (PubMed:16307917). Interacts with TRAF6 (PubMed:11057907, PubMed:16307917).3 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
FAM168A	Q92567	3	EBI-1050671,EBI-7957930
RNF111	Q6ZNA4	2	EBI-1050671,EBI-2129175
TRIM32	Q13049	3	EBI-1050671,EBI-742790
UBE2N	P61088	18	EBI-1050671,EBI-1052908
UBQLN1	Q9UMX0	5	EBI-1050671,EBI-741480
UBQLN1	Q9UMX0-2	3	EBI-1050671,EBI-10173939
XIAP	P98170	3	EBI-1050671,EBI-517127
ZNRF1	Q8ND25	2	EBI-1050671,EBI-2129250

Protein-protein interaction databases

BioGridⁱ	113183, 85 interactors 132321, 17 interactors
ComplexPortalⁱ	CPX-485 UBC13-UEV1A ubiquitin-conjugating enzyme E2 complex
CORUMⁱ	Q13404
Database of interacting proteins More...DIPⁱ	DIP-41911N
IntActⁱ	Q13404, 122 interactors
Molecular INTeraction database More...MINTⁱ	Q13404
STRINGⁱ	9606.ENSP00000340305

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	11 – 25	Combined sources	15
Beta strandⁱ	31 – 39	Combined sources	9
Beta strandⁱ	47 – 53	Combined sources	7
Beta strandⁱ	56 – 58	Combined sources	3
Turnⁱ	59 – 62	Combined sources	4
Beta strandⁱ	64 – 70	Combined sources	7
Turnⁱ	73 – 77	Combined sources	5
Beta strandⁱ	81 – 86	Combined sources	6
Beta strandⁱ	91 – 93	Combined sources	3
Turnⁱ	95 – 97	Combined sources	3
Helixⁱ	102 – 104	Combined sources	3
Helixⁱ	106 – 109	Combined sources	4
Helixⁱ	117 – 128	Combined sources	12
Turnⁱ	131 – 135	Combined sources	5

Show more details

3D structure databases

ProteinModelPortalⁱ	Q13404
SMRⁱ	Q13404
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	Q13404

EvolutionaryTraceⁱ

Q13404

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the ubiquitin-conjugating enzyme family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGⁱ	KOG0896 Eukaryota ENOG4111MDW LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00740000115534
HOGENOMⁱ	HOG000036561
HOVERGENⁱ	HBG054552
InParanoidⁱ	Q13404
KEGG Orthology (KO) More...KOⁱ	K10704 K20656
OMAⁱ	GHTVHEN
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0SMT
TreeFamⁱ	TF316971

Family and domain databases

Gene3Dⁱ	3.10.110.10, 1 hit
InterProⁱ	View protein in InterPro IPR000608 UBQ-conjugat_E2 IPR016135 UBQ-conjugating_enzyme/RWD
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00179 UQ_con, 1 hit
SUPFAMⁱ	SSF54495 SSF54495, 1 hit
PROSITEⁱ	View protein in PROSITE PS50127 UBIQUITIN_CONJUGAT_2, 1 hit

Sequences (6+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 6 isoformsⁱ produced by alternative splicing. Align Add to basket

Note: Additional isoforms seem to exist.

This entry has 6 described isoforms and 3 potential isoforms that are computationally mapped.Show all Align All

Isoform 3 (identifier: Q13404-4) [UniParc]FASTA Add to basket

Also known as: Isoform 2

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAATTGSGVK VPRNFRLLEE LEEGQKGVGD GTVSWGLEDD EDMTLTRWTG 
        60         70         80         90        100
MIIGPPRTIY ENRIYSLKIE CGPKYPEAPP FVRFVTKINM NGVNSSNGVV 
       110        120        130        140 
DPRAISVLAK WQNSYSIKVV LQELRRLMMS KENMKLPQPP EGQCYSN

Length:147

Mass (Da):16,495

Last modified:September 22, 2009 - v2

Checksum:ⁱBA53837F21977B3F

GO

Isoform 1 (identifier: Q13404-1) [UniParc]FASTA Add to basket

Also known as: CROC-1B, UEV-1B, Isoform 4

The sequence of this isoform differs from the canonical sequence as follows:
1-7: MAATTGS → MAYKFRTHSP...PHETYFCITT

« Hide

        10         20         30         40         50
MAYKFRTHSP EALEQLYPWE CFVFCLIIFG TFTNQIHKWS HTYFGLPRWV 
        60         70         80         90        100
TLLQDWHVIL PRKHHRIHHV SPHETYFCIT TGVKVPRNFR LLEELEEGQK 
       110        120        130        140        150
GVGDGTVSWG LEDDEDMTLT RWTGMIIGPP RTIYENRIYS LKIECGPKYP 
       160        170        180        190        200
EAPPFVRFVT KINMNGVNSS NGVVDPRAIS VLAKWQNSYS IKVVLQELRR 
       210        220 
LMMSKENMKL PQPPEGQCYS N

Show »

Length:221

Mass (Da):25,797

Checksum:ⁱ6EE5C0FCC8CBBEE6

GO

Isoform 2 (identifier: Q13404-2) [UniParc]FASTA Add to basket

Also known as: CROC-1A, UEV-1A

The sequence of this isoform differs from the canonical sequence as follows:
1-14: MAATTGSGVKVPRN → MPGEVQASYLKSQSKLSDEGRLEPRKFHCKGSKSPSQ

« Hide

        10         20         30         40         50
MPGEVQASYL KSQSKLSDEG RLEPRKFHCK GSKSPSQFRL LEELEEGQKG 
        60         70         80         90        100
VGDGTVSWGL EDDEDMTLTR WTGMIIGPPR TIYENRIYSL KIECGPKYPE 
       110        120        130        140        150
APPFVRFVTK INMNGVNSSN GVVDPRAISV LAKWQNSYSI KVVLQELRRL 
       160        170
MMSKENMKLP QPPEGQCYSN

Show »

Length:170

Mass (Da):19,228

Checksum:ⁱ9D3A8AC1EBEB22A6

GO

Isoform 4 (identifier: Q13404-6) [UniParc]FASTA Add to basket

Also known as: UEV-1As

The sequence of this isoform differs from the canonical sequence as follows:
1-44: Missing.
45-57: LTRWTGMIIGPPR → MKEDLNLENFTAK

« Hide

        10         20         30         40         50
MKEDLNLENF TAKTIYENRI YSLKIECGPK YPEAPPFVRF VTKINMNGVN 
        60         70         80         90        100
SSNGVVDPRA ISVLAKWQNS YSIKVVLQEL RRLMMSKENM KLPQPPEGQC 

YSN

Show »

Length:103

Mass (Da):11,842

Checksum:ⁱ76C152A73DE9AC40

GO

Isoform 5 (identifier: Q13404-7) [UniParc]FASTA Add to basket

Also known as: Isoform 3

The sequence of this isoform differs from the canonical sequence as follows:
1-7: MAATTGS → MPGEVQASYLKSQSKLSDEGRLEPRKFHCK

« Hide

        10         20         30         40         50
MPGEVQASYL KSQSKLSDEG RLEPRKFHCK GVKVPRNFRL LEELEEGQKG 
        60         70         80         90        100
VGDGTVSWGL EDDEDMTLTR WTGMIIGPPR TIYENRIYSL KIECGPKYPE 
       110        120        130        140        150
APPFVRFVTK INMNGVNSSN GVVDPRAISV LAKWQNSYSI KVVLQELRRL 
       160        170
MMSKENMKLP QPPEGQCYSN

Show »

Length:170

Mass (Da):19,307

Checksum:ⁱ5B2E8C6FFDF51510

GO

Isoform 6 (identifier: Q13404-8) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
58-99: Missing.

« Hide

        10         20         30         40         50
MAATTGSGVK VPRNFRLLEE LEEGQKGVGD GTVSWGLEDD EDMTLTRWTG 
        60         70         80         90        100
MIIGPPRVDP RAISVLAKWQ NSYSIKVVLQ ELRRLMMSKE NMKLPQPPEG 

QCYSN

Note: No experimental confirmation available.

Show »

Length:105

Mass (Da):11,766

Checksum:ⁱD7C2659FBA3FC719

GO

Computationally mapped potential isoform sequencesⁱ

There are 3 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

G3V2F7	G3V2F7_HUMAN	Ubiquitin-conjugating enzyme E2 var... Ubiquitin-conjugating enzyme E2 variant 1	UBE2V1	105	Annotation score:
A0A0A0MSL3	A0A0A0MSL3_HUMAN	Ubiquitin-conjugating enzyme E2 var... Ubiquitin-conjugating enzyme E2 variant 1	UBE2V1	103	Annotation score:
D6RG00	D6RG00_HUMAN	HCG2018358, isoform CRA_d HCG2018358, isoform CRA_d (Ubiquitin-conjugating enzyme E2 variant 1)	UBE2V1 hCG_2018358	89	Annotation score:

Sequence cautionⁱ

The sequence AAH08944 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Isoform 1 (identifier: Q13404-1)
Sequence conflictⁱ	71 – 81	SPHETYFCITT → WPTSSAQCYSP in AAC02755 (PubMed:9418904).CuratedAdd BLAST		11

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_038032	1 – 44	Missing in isoform 4. 1 PublicationAdd BLAST	44
Alternative sequenceⁱVSP_038033	1 – 14	MAATT…KVPRN → MPGEVQASYLKSQSKLSDEG RLEPRKFHCKGSKSPSQ in isoform 2. 2 PublicationsAdd BLAST	14
Alternative sequenceⁱVSP_038034	1 – 7	MAATTGS → MAYKFRTHSPEALEQLYPWE CFVFCLIIFGTFTNQIHKWS HTYFGLPRWVTLLQDWHVIL PRKHHRIHHVSPHETYFCIT T in isoform 1. 3 Publications	7
Alternative sequenceⁱVSP_038035	1 – 7	MAATTGS → MPGEVQASYLKSQSKLSDEG RLEPRKFHCK in isoform 5. 1 Publication	7
Alternative sequenceⁱVSP_038036	45 – 57	LTRWT…IGPPR → MKEDLNLENFTAK in isoform 4. 1 PublicationAdd BLAST	13
Alternative sequenceⁱVSP_044818	58 – 99	Missing in isoform 6. 1 PublicationAdd BLAST	42

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U39360 mRNA Translation: AAB72015.1 U39361 mRNA Translation: AAB72016.1 U49278 mRNA Translation: AAC02757.1 U97279 mRNA Translation: AAC02780.1 U97280 mRNA Translation: AAC02755.1 U97281 mRNA Translation: AAC02756.1 AY008273 mRNA Translation: AAG24229.1 BT007382 mRNA Translation: AAP36046.1 DA580976 mRNA No translation available. AL034423 Genomic DNA No translation available. CH471077 Genomic DNA Translation: EAW75635.1 CH471077 Genomic DNA Translation: EAW75634.1 CH471077 Genomic DNA Translation: EAW75636.1 BC000468 mRNA Translation: AAH00468.1 BC008944 mRNA Translation: AAH08944.2 Different initiation.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS13426.1 [Q13404-7] CCDS13427.1 [Q13404-6] CCDS33483.1 [Q13404-4] CCDS58775.1 [Q13404-8]
NCBI Reference Sequences More...RefSeqⁱ	NP_001027459.1, NM_001032288.2 [Q13404-4] NP_001244322.1, NM_001257393.1 [Q13404-7] NP_001244323.1, NM_001257394.1 [Q13404-6] NP_001244325.1, NM_001257396.1 [Q13404-8] NP_068823.2, NM_021988.5 [Q13404-7] NP_071887.1, NM_022442.5 [Q13404-6] NP_954595.1, NM_199144.2 [Q13404-7] NP_954673.1, NM_199203.2
UniGeneⁱ	Hs.420529 Hs.744839

Genome annotation databases

Ensemblⁱ	ENST00000340309; ENSP00000340305; ENSG00000244687 [Q13404-7] ENST00000371657; ENSP00000360720; ENSG00000244687 [Q13404-8] ENST00000371674; ENSP00000360739; ENSG00000244687 [Q13404-4] ENST00000371677; ENSP00000360742; ENSG00000244687 [Q13404-7] ENST00000415862; ENSP00000407770; ENSG00000244687 [Q13404-6]
GeneIDⁱ	387522 7335
KEGGⁱ	hsa:387522 hsa:7335
UCSC genome browser More...UCSCⁱ	uc002xva.5 human [Q13404-4]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q13404	Ubiquitin-conjugating enzyme E2 variant 1		BOVIN		147	UniRef100_Q13404
Uncharacterized protein DKFZp459C1112		PONAB		110
Ubiquitin-conjugating enzyme E2 variant 1 isoform d		CALJA		147
Ubiquitin-conjugating enzyme E2 variant 1		PANTR		147
Ubiquitin conjugating enzyme E2 V1		AOTNA		147
+28
Q13404-1	HCG2044781		HUMAN		370	UniRef100_I3L0A0
Q13404-6	Uncharacterized protein		PANTR		103	UniRef100_A0A2I3SY02
Uncharacterized protein		PANPA		103
Ubiquitin conjugating enzyme E2 V1		GORGO		103
Uncharacterized protein		NOMLE		101
Q13404-7	Ubiquitin-conjugating enzyme E2 variant 1		PANTR		170	UniRef100_K7DI65
Uncharacterized protein		PANPA		170
Ubiquitin conjugating enzyme E2 V1		GORGO		170
UPI0008F4E579		GORGO		183
Q13404-8	Uncharacterized protein		CALJA		105	UniRef100_A0A2R8NEY6
ubiquitin-conjugating enzyme E2 variant 1-like isoform X3		BALAS		105
Uncharacterized protein		MACMU		105
Uncharacterized protein		Cebus capucinus imitator		105
ubiquitin-conjugating enzyme E2 variant 1 isoform X2		ODORO		105
+17

Protein	Similar proteins		Species	Score	Length	Source
Q13404	Ubiquitin-conjugating enzyme E2 variant 1		BOVIN		147	UniRef90_Q13404
Uncharacterized protein DKFZp459C1112		PONAB		110
Ubiquitin-conjugating enzyme E2 variant 1 isoform d		CALJA		147
Ubiquitin-conjugating enzyme E2 variant 1		PANTR		147
Ubiquitin conjugating enzyme E2 V1		AOTNA		147
+28
Q13404-1	HCG2044781		HUMAN		370	UniRef90_I3L0A0
Predicted gene 20431		MOUSE		371
Uncharacterized protein		MACMU		370
TMEM189-UBE2V1 readthrough		CHLSB		370
TMEM189-UBE2V1 readthrough		AILME		370
+9
Q13404-2	Ubiquitin-conjugating enzyme E2 variant 1		PONAB		147	UniRef90_Q13404-2
Uncharacterized protein		Cebus capucinus imitator		173
Ubiquitin-conjugating enzyme E2 variant 1		PANTR		170
Uncharacterized protein		PANPA		170
Ubiquitin conjugating enzyme E2 V1		GORGO		170
+99
Q13404-6	Uncharacterized protein		PANTR		103	UniRef90_A0A2I3SY02
Uncharacterized protein		PANPA		103
Ubiquitin conjugating enzyme E2 V1		GORGO		103
Uncharacterized protein		NOMLE		101
Uncharacterized protein		MACMU		103
+7
Q13404-7	Isoform 2 of Ubiquitin-conjugating enzyme E2 variant 1		HUMAN		170	UniRef90_Q13404-2
Ubiquitin-conjugating enzyme E2 variant 1		PONAB		147
Uncharacterized protein		Cebus capucinus imitator		173
Ubiquitin-conjugating enzyme E2 variant 1		PANTR		170
Uncharacterized protein		PANPA		170
+99
Q13404-8	Uncharacterized protein		CAVPO		103	UniRef90_A0A286X7U8
ubiquitin-conjugating enzyme E2 variant 2 isoform X2		ERIEU		103
ubiquitin-conjugating enzyme E2 variant 2 isoform X3		Florida manatee		103
Uncharacterized protein		ICTTR		103
Uncharacterized protein		CALJA		105
+29

Protein	Similar proteins		Species	Score	Length	Source
Q13404	Ubiquitin-conjugating enzyme E2 variant 1		BOVIN		147	UniRef50_Q13404
Uncharacterized protein DKFZp459C1112		PONAB		110
Ubiquitin-conjugating enzyme E2 variant 1 isoform d		CALJA		147
Ubiquitin-conjugating enzyme E2 variant 1		PANTR		147
Ubiquitin conjugating enzyme E2 V1		AOTNA		147
+33
Q13404-1	HCG2044781		HUMAN		370	UniRef50_I3L0A0
Predicted gene 20431		MOUSE		371
TMEM189-UBE2V1 readthrough		AILME		370
TMEM189-UBE2V1 readthrough		CHLSB		370
Uncharacterized protein		MACMU		370
+62
Q13404-2	Ubiquitin-conjugating enzyme E2 variant 1		PONAB		147	UniRef50_Q13404-2
Ubiquitin-conjugating enzyme E2 variant 2		DANRE		145
Ubiquitin-conjugating enzyme E2 variant 2		MOUSE		145
Ubiquitin-conjugating enzyme E2 variant 2		RAT		145
Ubiquitin-conjugating enzyme E2 variant 2		XENLA		145
+351
Q13404-6	Ubiquitin-conjugating enzyme E2 variant 2 (Fragment)		HUMAN		109	UniRef50_H0YBP9
UBE2V2 isoform 2 (Fragment)		PONAB		108
UBE2V2 isoform 2 (Fragment)		PANTR		108
Uncharacterized protein		GORGO		126
Ubiquitin-conjugating enzyme E2 variant 2 (Fragment)		Draco beccarii		93
+94
Q13404-7	Isoform 2 of Ubiquitin-conjugating enzyme E2 variant 1		HUMAN		170	UniRef50_Q13404-2
Ubiquitin-conjugating enzyme E2 variant 1		PONAB		147
Ubiquitin-conjugating enzyme E2 variant 2		DANRE		145
Ubiquitin-conjugating enzyme E2 variant 2		MOUSE		145
Ubiquitin-conjugating enzyme E2 variant 2		RAT		145
+351
Q13404-8	Isoform 2 of Ubiquitin-conjugating enzyme E2 variant 1		MOUSE		105	UniRef50_Q9CZY3-2
Uncharacterized protein		PROCO		105
ubiquitin-conjugating enzyme E2 variant 1-like isoform X2		ERIEU		105
Uncharacterized protein		CALJA		105
ubiquitin-conjugating enzyme E2 variant 1-like isoform X3		BALAS		105
+77

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U39360 mRNA Translation: AAB72015.1 U39361 mRNA Translation: AAB72016.1 U49278 mRNA Translation: AAC02757.1 U97279 mRNA Translation: AAC02780.1 U97280 mRNA Translation: AAC02755.1 U97281 mRNA Translation: AAC02756.1 AY008273 mRNA Translation: AAG24229.1 BT007382 mRNA Translation: AAP36046.1 DA580976 mRNA No translation available. AL034423 Genomic DNA No translation available. CH471077 Genomic DNA Translation: EAW75635.1 CH471077 Genomic DNA Translation: EAW75634.1 CH471077 Genomic DNA Translation: EAW75636.1 BC000468 mRNA Translation: AAH00468.1 BC008944 mRNA Translation: AAH08944.2 Different initiation.
CCDSⁱ	CCDS13426.1 [Q13404-7] CCDS13427.1 [Q13404-6] CCDS33483.1 [Q13404-4] CCDS58775.1 [Q13404-8]
RefSeqⁱ	NP_001027459.1, NM_001032288.2 [Q13404-4] NP_001244322.1, NM_001257393.1 [Q13404-7] NP_001244323.1, NM_001257394.1 [Q13404-6] NP_001244325.1, NM_001257396.1 [Q13404-8] NP_068823.2, NM_021988.5 [Q13404-7] NP_071887.1, NM_022442.5 [Q13404-6] NP_954595.1, NM_199144.2 [Q13404-7] NP_954673.1, NM_199203.2
UniGeneⁱ	Hs.420529 Hs.744839

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2A4D	X-ray	1.69	A	8-147	[»]
	2C2V	X-ray	2.90	C/F/I/L	8-147	[»]
	2HLW	NMR	-	A	8-147	[»]
ProteinModelPortalⁱ	Q13404
SMRⁱ	Q13404
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	113183, 85 interactors 132321, 17 interactors
ComplexPortalⁱ	CPX-485 UBC13-UEV1A ubiquitin-conjugating enzyme E2 complex
CORUMⁱ	Q13404
DIPⁱ	DIP-41911N
IntActⁱ	Q13404, 122 interactors
MINTⁱ	Q13404
STRINGⁱ	9606.ENSP00000340305

Protein family/group databases

MoonDBⁱ	Q13404 Predicted

MoonDBⁱ

Q13404 Predicted

PTM databases

iPTMnetⁱ	Q13404
PhosphoSitePlusⁱ	Q13404
SwissPalmⁱ	Q13404

Polymorphism and mutation databases

BioMutaⁱ	UBE2V1
DMDMⁱ	259016163

Proteomic databases

EPDⁱ	Q13404
MaxQBⁱ	Q13404
PaxDbⁱ	Q13404
PeptideAtlasⁱ	Q13404
PRIDEⁱ	Q13404
ProteomicsDBⁱ	59382 59383 [Q13404-1] 59384 [Q13404-2] 59385 [Q13404-6] 59386 [Q13404-7]
TopDownProteomicsⁱ	Q13404-4 [Q13404-4]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	387522 7335
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000340309; ENSP00000340305; ENSG00000244687 [Q13404-7] ENST00000371657; ENSP00000360720; ENSG00000244687 [Q13404-8] ENST00000371674; ENSP00000360739; ENSG00000244687 [Q13404-4] ENST00000371677; ENSP00000360742; ENSG00000244687 [Q13404-7] ENST00000415862; ENSP00000407770; ENSG00000244687 [Q13404-6]
GeneIDⁱ	387522 7335
KEGGⁱ	hsa:387522 hsa:7335
UCSCⁱ	uc002xva.5 human [Q13404-4]

Organism-specific databases

CTDⁱ	387522 7335
DisGeNETⁱ	387521 387522 7335
EuPathDBⁱ	HostDB:ENSG00000244687.11
GeneCardsⁱ	UBE2V1
HGNCⁱ	HGNC:12494 UBE2V1
HPAⁱ	HPA052535 HPA053186
MIMⁱ	602995 gene
neXtProtⁱ	NX_Q13404
OpenTargetsⁱ	ENSG00000244687
PharmGKBⁱ	PA37142
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0896 Eukaryota ENOG4111MDW LUCA
GeneTreeⁱ	ENSGT00740000115534
HOGENOMⁱ	HOG000036561
HOVERGENⁱ	HBG054552
InParanoidⁱ	Q13404
KOⁱ	K10704 K20656
OMAⁱ	GHTVHEN
OrthoDBⁱ	EOG091G0SMT
TreeFamⁱ	TF316971

Enzyme and pathway databases

BRENDAⁱ	2.3.2.B6 2681
Reactomeⁱ	R-HSA-168638 NOD1/2 Signaling Pathway R-HSA-168927 TICAM1, RIP1-mediated IKK complex recruitment R-HSA-202424 Downstream TCR signaling R-HSA-2871837 FCERI mediated NF-kB activation R-HSA-445989 TAK1 activates NFkB by phosphorylation and activation of IKKs complex R-HSA-450302 activated TAK1 mediates p38 MAPK activation R-HSA-450321 JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-5607764 CLEC7A (Dectin-1) signaling R-HSA-9020702 Interleukin-1 signaling R-HSA-937039 IRAK1 recruits IKK complex R-HSA-937041 IKK complex recruitment mediated by RIP1 R-HSA-975110 TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling R-HSA-975144 IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation
SignaLinkⁱ	Q13404
SIGNORⁱ	Q13404

Miscellaneous databases

ChiTaRSⁱ	UBE2V1 human
EvolutionaryTraceⁱ	Q13404
GeneWikiⁱ	UBE2V1
Protein Ontology More...PROⁱ	PR:Q13404
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000244687 Expressed in 94 organ(s), highest expression level in frontal cortex
ExpressionAtlasⁱ	Q13404 baseline and differential
Genevisibleⁱ	Q13404 HS

Family and domain databases

Gene3Dⁱ	3.10.110.10, 1 hit
InterProⁱ	View protein in InterPro IPR000608 UBQ-conjugat_E2 IPR016135 UBQ-conjugating_enzyme/RWD
Pfamⁱ	View protein in Pfam PF00179 UQ_con, 1 hit
SUPFAMⁱ	SSF54495 SSF54495, 1 hit
PROSITEⁱ	View protein in PROSITE PS50127 UBIQUITIN_CONJUGAT_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	UB2V1_HUMAN
Accessionⁱ	Q13404Primary (citable) accession number: Q13404 Secondary accession number(s): E1P629 Q9UM50
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	August 31, 2004
	Last sequence update:	September 22, 2009
	Last modified:	November 7, 2018
	This is version 188 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 20
Human chromosome 20: entries, gene names and cross-references to MIM
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

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UniProtKB - Q13404 (UB2V1_HUMAN)

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Ubiquitin-conjugating enzyme E2 variant 1

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

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Enzyme and pathway databases

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Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

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Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

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Sequence databases

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Protein-protein interaction databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ