UniProtKB - Q13404 (UB2V1_HUMAN)
Ubiquitin-conjugating enzyme E2 variant 1
UBE2V1
Functioni
Miscellaneous
GO - Molecular functioni
- ubiquitin conjugating enzyme activity Source: GO_Central
GO - Biological processi
- activation of MAPK activity Source: Reactome
- cell differentiation Source: UniProtKB
- interleukin-1-mediated signaling pathway Source: Reactome
- JNK cascade Source: Reactome
- nucleotide-binding oligomerization domain containing signaling pathway Source: Reactome
- positive regulation of I-kappaB kinase/NF-kappaB signaling Source: HGNC-UCL
- positive regulation of NF-kappaB transcription factor activity Source: HGNC-UCL
- positive regulation of transcription, DNA-templated Source: UniProtKB
- postreplication repair Source: GO_Central
- protein K63-linked ubiquitination Source: UniProtKB
- protein polyubiquitination Source: GO_Central
- regulation of DNA repair Source: ProtInc
- regulation of transcription, DNA-templated Source: UniProtKB
Keywordsi
Biological process | Ubl conjugation pathway |
Enzyme and pathway databases
BRENDAi | 2.3.2.B6, 2681 |
PathwayCommonsi | Q13404 |
Reactomei | R-HSA-168638, NOD1/2 Signaling Pathway R-HSA-168927, TICAM1, RIP1-mediated IKK complex recruitment R-HSA-202424, Downstream TCR signaling R-HSA-2871837, FCERI mediated NF-kB activation R-HSA-445989, TAK1 activates NFkB by phosphorylation and activation of IKKs complex R-HSA-450302, activated TAK1 mediates p38 MAPK activation R-HSA-450321, JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-5607764, CLEC7A (Dectin-1) signaling R-HSA-9020702, Interleukin-1 signaling R-HSA-937039, IRAK1 recruits IKK complex R-HSA-937041, IKK complex recruitment mediated by RIP1 R-HSA-9646399, Aggrephagy R-HSA-975110, TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling R-HSA-975144, IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation R-HSA-983168, Antigen processing: Ubiquitination & Proteasome degradation |
SignaLinki | Q13404 |
SIGNORi | Q13404 |
Protein family/group databases
MoonDBi | Q13404, Predicted |
Names & Taxonomyi
Protein namesi | Recommended name: Ubiquitin-conjugating enzyme E2 variant 1Short name: UEV-1 Alternative name(s): CROC-1 TRAF6-regulated IKK activator 1 beta Uev1A |
Gene namesi | Name:UBE2V1 Synonyms:CROC1, UBE2V, UEV1 ORF Names:P/OKcl.19 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:12494, UBE2V1 |
MIMi | 602995, gene |
neXtProti | NX_Q13404 |
VEuPathDBi | HostDB:ENSG00000244687.11 |
Subcellular locationi
Nucleus
- Nucleus 2 Publications
Note: Excluded from the nucleolus.
Cytosol
- cytosol Source: Reactome
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
Nucleus
- nucleoplasm Source: HPA
- nucleus Source: GO_Central
Other locations
- cytoplasm Source: HGNC-UCL
- protein-containing complex Source: MGI
- UBC13-UEV1A complex Source: UniProtKB
- ubiquitin conjugating enzyme complex Source: HGNC-UCL
- ubiquitin ligase complex Source: UniProtKB
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 387522 7335 |
OpenTargetsi | ENSG00000244687 |
PharmGKBi | PA37142 |
Miscellaneous databases
Pharosi | Q13404, Tbio |
Genetic variation databases
BioMutai | UBE2V1 |
DMDMi | 259016163 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedCombined sources1 Publication | |||
ChainiPRO_0000082600 | 2 – 147 | Ubiquitin-conjugating enzyme E2 variant 1Add BLAST | 146 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylalanineCombined sources1 Publication | 1 |
Keywords - PTMi
AcetylationProteomic databases
EPDi | Q13404 |
jPOSTi | Q13404 |
MassIVEi | Q13404 |
MaxQBi | Q13404 |
PaxDbi | Q13404 |
PeptideAtlasi | Q13404 |
PRIDEi | Q13404 |
ProteomicsDBi | 59382 [Q13404-4] 59383 [Q13404-1] 59384 [Q13404-2] 59385 [Q13404-6] 59386 [Q13404-7] 65114 |
TopDownProteomicsi | Q13404-4 [Q13404-4] |
PTM databases
iPTMneti | Q13404 |
PhosphoSitePlusi | Q13404 |
SwissPalmi | Q13404 |
Expressioni
Tissue specificityi
Inductioni
Gene expression databases
Bgeei | ENSG00000244687, Expressed in frontal cortex and 118 other tissues |
ExpressionAtlasi | Q13404, baseline and differential |
Genevisiblei | Q13404, HS |
Organism-specific databases
HPAi | ENSG00000244687, Low tissue specificity |
Interactioni
Subunit structurei
Heterodimer with UBE2N (PubMed:11057907, PubMed:16307917, PubMed:16893187).
Interacts (UBE2V2-UBE2N heterodimer) with the E3 ligase STUB1 (via the U-box domain); the complex has a specific 'Lys-63'-linked polyubiquitination activity (PubMed:16307917).
Interacts with TRAF6 (PubMed:11057907, PubMed:16307917).
3 PublicationsBinary interactionsi
Hide detailsQ13404
Isoform 2 [Q13404-2]
With | #Exp. | IntAct |
---|---|---|
UBE2N [P61088] | 2 | EBI-15972179,EBI-1052908 |
Protein-protein interaction databases
BioGRIDi | 113183, 97 interactors 132321, 33 interactors |
ComplexPortali | CPX-485, UBC13-UEV1A ubiquitin-conjugating enzyme E2 complex |
CORUMi | Q13404 |
DIPi | DIP-41911N |
IntActi | Q13404, 136 interactors |
MINTi | Q13404 |
STRINGi | 9606.ENSP00000340305 |
Miscellaneous databases
RNActi | Q13404, protein |
Structurei
Secondary structure
3D structure databases
BMRBi | Q13404 |
SMRi | Q13404 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q13404 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 12 – 147 | UBC corePROSITE-ProRule annotationAdd BLAST | 136 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG0896, Eukaryota |
GeneTreei | ENSGT00740000115534 |
HOGENOMi | CLU_063065_1_2_1 |
InParanoidi | Q13404 |
OMAi | FTMETIL |
OrthoDBi | 1507995at2759 |
TreeFami | TF316971 |
Family and domain databases
Gene3Di | 3.10.110.10, 1 hit |
InterProi | View protein in InterPro IPR000608, UBQ-conjugat_E2 IPR016135, UBQ-conjugating_enzyme/RWD |
Pfami | View protein in Pfam PF00179, UQ_con, 1 hit |
SUPFAMi | SSF54495, SSF54495, 1 hit |
PROSITEi | View protein in PROSITE PS50127, UBC_2, 1 hit |
s (6+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 6 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 6 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAATTGSGVK VPRNFRLLEE LEEGQKGVGD GTVSWGLEDD EDMTLTRWTG
60 70 80 90 100
MIIGPPRTIY ENRIYSLKIE CGPKYPEAPP FVRFVTKINM NGVNSSNGVV
110 120 130 140
DPRAISVLAK WQNSYSIKVV LQELRRLMMS KENMKLPQPP EGQCYSN
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketD6RG00 | D6RG00_HUMAN | HCG2018358, isoform CRA_d | UBE2V1 hCG_2018358 | 89 | Annotation score: | ||
G3V2F7 | G3V2F7_HUMAN | Ubiquitin-conjugating enzyme E2 var... | UBE2V1 | 105 | Annotation score: | ||
A0A0A0MSL3 | A0A0A0MSL3_HUMAN | Ubiquitin-conjugating enzyme E2 var... | UBE2V1 | 103 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length | |
---|---|---|---|---|---|
Isoform 1 (identifier: Q13404-1) | |||||
Sequence conflicti | 71 – 81 | SPHETYFCITT → WPTSSAQCYSP in AAC02755 (PubMed:9418904).CuratedAdd BLAST | 11 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_038032 | 1 – 44 | Missing in isoform 4. 1 PublicationAdd BLAST | 44 | |
Alternative sequenceiVSP_038033 | 1 – 14 | MAATT…KVPRN → MPGEVQASYLKSQSKLSDEG RLEPRKFHCKGSKSPSQ in isoform 2. 2 PublicationsAdd BLAST | 14 | |
Alternative sequenceiVSP_038034 | 1 – 7 | MAATTGS → MAYKFRTHSPEALEQLYPWE CFVFCLIIFGTFTNQIHKWS HTYFGLPRWVTLLQDWHVIL PRKHHRIHHVSPHETYFCIT T in isoform 1. 3 Publications | 7 | |
Alternative sequenceiVSP_038035 | 1 – 7 | MAATTGS → MPGEVQASYLKSQSKLSDEG RLEPRKFHCK in isoform 5. 1 Publication | 7 | |
Alternative sequenceiVSP_038036 | 45 – 57 | LTRWT…IGPPR → MKEDLNLENFTAK in isoform 4. 1 PublicationAdd BLAST | 13 | |
Alternative sequenceiVSP_044818 | 58 – 99 | Missing in isoform 6. 1 PublicationAdd BLAST | 42 |
Sequence databases
Genome annotation databases
Ensembli | ENST00000340309; ENSP00000340305; ENSG00000244687 [Q13404-7] ENST00000371657; ENSP00000360720; ENSG00000244687 [Q13404-8] ENST00000371674; ENSP00000360739; ENSG00000244687 [Q13404-4] ENST00000371677; ENSP00000360742; ENSG00000244687 [Q13404-7] ENST00000415862; ENSP00000407770; ENSG00000244687 [Q13404-6] |
GeneIDi | 387522 7335 |
KEGGi | hsa:387522 hsa:7335 |
UCSCi | uc002xva.5, human [Q13404-4] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2A4D | X-ray | 1.69 | A | 8-147 | [»] | |
2C2V | X-ray | 2.90 | C/F/I/L | 8-147 | [»] | |
2HLW | NMR | - | A | 8-147 | [»] | |
6D6I | X-ray | 2.55 | A/D | 8-147 | [»] | |
BMRBi | Q13404 | |||||
SMRi | Q13404 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 113183, 97 interactors 132321, 33 interactors |
ComplexPortali | CPX-485, UBC13-UEV1A ubiquitin-conjugating enzyme E2 complex |
CORUMi | Q13404 |
DIPi | DIP-41911N |
IntActi | Q13404, 136 interactors |
MINTi | Q13404 |
STRINGi | 9606.ENSP00000340305 |
Protein family/group databases
MoonDBi | Q13404, Predicted |
PTM databases
iPTMneti | Q13404 |
PhosphoSitePlusi | Q13404 |
SwissPalmi | Q13404 |
Genetic variation databases
BioMutai | UBE2V1 |
DMDMi | 259016163 |
Proteomic databases
EPDi | Q13404 |
jPOSTi | Q13404 |
MassIVEi | Q13404 |
MaxQBi | Q13404 |
PaxDbi | Q13404 |
PeptideAtlasi | Q13404 |
PRIDEi | Q13404 |
ProteomicsDBi | 59382 [Q13404-4] 59383 [Q13404-1] 59384 [Q13404-2] 59385 [Q13404-6] 59386 [Q13404-7] 65114 |
TopDownProteomicsi | Q13404-4 [Q13404-4] |
Protocols and materials databases
Antibodypediai | 35021, 258 antibodies |
DNASUi | 387522 7335 |
Genome annotation databases
Ensembli | ENST00000340309; ENSP00000340305; ENSG00000244687 [Q13404-7] ENST00000371657; ENSP00000360720; ENSG00000244687 [Q13404-8] ENST00000371674; ENSP00000360739; ENSG00000244687 [Q13404-4] ENST00000371677; ENSP00000360742; ENSG00000244687 [Q13404-7] ENST00000415862; ENSP00000407770; ENSG00000244687 [Q13404-6] |
GeneIDi | 387522 7335 |
KEGGi | hsa:387522 hsa:7335 |
UCSCi | uc002xva.5, human [Q13404-4] |
Organism-specific databases
CTDi | 387522 7335 |
DisGeNETi | 387522 7335 |
GeneCardsi | UBE2V1 |
HGNCi | HGNC:12494, UBE2V1 |
HPAi | ENSG00000244687, Low tissue specificity |
MIMi | 602995, gene |
neXtProti | NX_Q13404 |
OpenTargetsi | ENSG00000244687 |
PharmGKBi | PA37142 |
VEuPathDBi | HostDB:ENSG00000244687.11 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0896, Eukaryota |
GeneTreei | ENSGT00740000115534 |
HOGENOMi | CLU_063065_1_2_1 |
InParanoidi | Q13404 |
OMAi | FTMETIL |
OrthoDBi | 1507995at2759 |
TreeFami | TF316971 |
Enzyme and pathway databases
BRENDAi | 2.3.2.B6, 2681 |
PathwayCommonsi | Q13404 |
Reactomei | R-HSA-168638, NOD1/2 Signaling Pathway R-HSA-168927, TICAM1, RIP1-mediated IKK complex recruitment R-HSA-202424, Downstream TCR signaling R-HSA-2871837, FCERI mediated NF-kB activation R-HSA-445989, TAK1 activates NFkB by phosphorylation and activation of IKKs complex R-HSA-450302, activated TAK1 mediates p38 MAPK activation R-HSA-450321, JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-5607764, CLEC7A (Dectin-1) signaling R-HSA-9020702, Interleukin-1 signaling R-HSA-937039, IRAK1 recruits IKK complex R-HSA-937041, IKK complex recruitment mediated by RIP1 R-HSA-9646399, Aggrephagy R-HSA-975110, TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling R-HSA-975144, IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation R-HSA-983168, Antigen processing: Ubiquitination & Proteasome degradation |
SignaLinki | Q13404 |
SIGNORi | Q13404 |
Miscellaneous databases
BioGRID-ORCSi | 387522, 65 hits in 822 CRISPR screens 7335, 212 hits in 856 CRISPR screens |
ChiTaRSi | UBE2V1, human |
EvolutionaryTracei | Q13404 |
GeneWikii | UBE2V1 |
Pharosi | Q13404, Tbio |
PROi | PR:Q13404 |
RNActi | Q13404, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000244687, Expressed in frontal cortex and 118 other tissues |
ExpressionAtlasi | Q13404, baseline and differential |
Genevisiblei | Q13404, HS |
Family and domain databases
Gene3Di | 3.10.110.10, 1 hit |
InterProi | View protein in InterPro IPR000608, UBQ-conjugat_E2 IPR016135, UBQ-conjugating_enzyme/RWD |
Pfami | View protein in Pfam PF00179, UQ_con, 1 hit |
SUPFAMi | SSF54495, SSF54495, 1 hit |
PROSITEi | View protein in PROSITE PS50127, UBC_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | UB2V1_HUMAN | |
Accessioni | Q13404Primary (citable) accession number: Q13404 Secondary accession number(s): E1P629 Q9UM50 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 31, 2004 |
Last sequence update: | September 22, 2009 | |
Last modified: | February 10, 2021 | |
This is version 202 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Human chromosome 20
Human chromosome 20: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families