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Protein

Putative postmeiotic segregation increased 2-like protein 3

Gene

PMS2P3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Protein uncertaini

Functioni

Miscellaneous

Encoded by one of the numerous copies of postmeiotic segregation increased 2-like genes scattered in the q11-q22 region of the chromosome 7.

Caution

Could be the product of a pseudogene.Curated

GO - Molecular functioni

  • ATPase activity Source: GO_Central
  • single-stranded DNA binding Source: GO_Central

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Putative postmeiotic segregation increased 2-like protein 3
Alternative name(s):
PMS2-related protein 3
Postmeiotic segregation increased 2-like protein 9
Postmeiotic segregation increased protein 5
Putative postmeiotic segregation increased 2 pseudogene 3
Gene namesi
Name:PMS2P3
Synonyms:PMS2L3, PMS2L9, PMS5, PMSR3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:9128 PMS2P3
neXtProtiNX_Q13401

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi5387

Polymorphism and mutation databases

DMDMi313104156

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003111001 – 168Putative postmeiotic segregation increased 2-like protein 3Add BLAST168

Proteomic databases

EPDiQ13401
MaxQBiQ13401
PeptideAtlasiQ13401
PRIDEiQ13401
ProteomicsDBi59372
59373 [Q13401-2]
59374 [Q13401-3]

Expressioni

Gene expression databases

CleanExiHS_PMS2L3

Interactioni

Protein-protein interaction databases

IntActiQ13401, 1 interactor

Structurei

3D structure databases

ProteinModelPortaliQ13401
SMRiQ13401
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini8 – 84KRABPROSITE-ProRule annotationAdd BLAST77

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1978 Eukaryota
COG0323 LUCA
HOGENOMiHOG000231475
HOVERGENiHBG067759
InParanoidiQ13401
PhylomeDBiQ13401

Family and domain databases

CDDicd00075 HATPase_c, 1 hit
cd07765 KRAB_A-box, 1 hit
Gene3Di3.30.565.10, 1 hit
InterProiView protein in InterPro
IPR003594 HATPase_C
IPR036890 HATPase_C_sf
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR038973 MutL/Mlh/Pms
PANTHERiPTHR10073 PTHR10073, 1 hit
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SUPFAMiSSF109640 SSF109640, 1 hit
SSF55874 SSF55874, 1 hit
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q13401-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MNTLQGPVSF KDVAVDFTQE EWRQLDPDEK IAYGDVMLEN YSHLVSVGYD
60 70 80 90 100
YHQAKHHHGV EVKEVEQGEE PWIMEGEFPC QHSPEPAKAI KPIDRKSVHQ
110 120 130 140 150
ICSGPVVLSL STAVKELVEN SLDAGATNID LKLKDYGVDL IEVSDNGCGV
160
EEENFEGLIS FSSETSHM
Length:168
Mass (Da):18,716
Last modified:November 30, 2010 - v2
Checksum:i995B2A9EC5AA3835
GO
Isoform 2 (identifier: Q13401-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     159-168: ISFSSETSHM → TMSPFLPATRR

Note: No experimental confirmation available.
Show »
Length:169
Mass (Da):18,867
Checksum:iE183275BF809864A
GO
Isoform 3 (identifier: Q13401-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     85-168: EPAKAIKPID...ISFSSETSHM → VQNLLRPSNLLIGSQSIRFALGQWY

Show »
Length:109
Mass (Da):12,600
Checksum:i9D727DAAB3B86A0D
GO

Sequence cautioni

The sequence AAA97459 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti23R → W in BC029646 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04028985 – 168EPAKA…ETSHM → VQNLLRPSNLLIGSQSIRFA LGQWY in isoform 3. 1 PublicationAdd BLAST84
Alternative sequenceiVSP_040290159 – 168ISFSSETSHM → TMSPFLPATRR in isoform 2. 1 Publication10

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U38979 Genomic DNA Translation: AAA97459.1 Sequence problems.
CR621744 mRNA No translation available.
AC018720 Genomic DNA No translation available.
CH471220 Genomic DNA Translation: EAW71766.1
BC029646 mRNA No translation available.
BC101598 mRNA Translation: AAI01599.1
UniGeneiHs.659871
Hs.661055

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U38979 Genomic DNA Translation: AAA97459.1 Sequence problems.
CR621744 mRNA No translation available.
AC018720 Genomic DNA No translation available.
CH471220 Genomic DNA Translation: EAW71766.1
BC029646 mRNA No translation available.
BC101598 mRNA Translation: AAI01599.1
UniGeneiHs.659871
Hs.661055

3D structure databases

ProteinModelPortaliQ13401
SMRiQ13401
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ13401, 1 interactor

Polymorphism and mutation databases

DMDMi313104156

Proteomic databases

EPDiQ13401
MaxQBiQ13401
PeptideAtlasiQ13401
PRIDEiQ13401
ProteomicsDBi59372
59373 [Q13401-2]
59374 [Q13401-3]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

DisGeNETi5387
GeneCardsiPMS2P3
HGNCiHGNC:9128 PMS2P3
neXtProtiNX_Q13401
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1978 Eukaryota
COG0323 LUCA
HOGENOMiHOG000231475
HOVERGENiHBG067759
InParanoidiQ13401
PhylomeDBiQ13401

Miscellaneous databases

ChiTaRSiPMS2P3 human
PROiPR:Q13401

Gene expression databases

CleanExiHS_PMS2L3

Family and domain databases

CDDicd00075 HATPase_c, 1 hit
cd07765 KRAB_A-box, 1 hit
Gene3Di3.30.565.10, 1 hit
InterProiView protein in InterPro
IPR003594 HATPase_C
IPR036890 HATPase_C_sf
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR038973 MutL/Mlh/Pms
PANTHERiPTHR10073 PTHR10073, 1 hit
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SUPFAMiSSF109640 SSF109640, 1 hit
SSF55874 SSF55874, 1 hit
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPM2P3_HUMAN
AccessioniPrimary (citable) accession number: Q13401
Secondary accession number(s): A6NG70, Q3MJ29
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: November 30, 2010
Last modified: November 7, 2018
This is version 123 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
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