UniProtKB - Q13395 (TARB1_HUMAN)
Probable methyltransferase TARBP1
TARBP1
Functioni
Probable S-adenosyl-L-methionine-dependent methyltransferase which methylates RNA molecules such as tRNAs.
1 Publication(Microbial infection) In case of infection by HIV-1, it binds to the loop region of TAR RNA, a region also bound by RNA polymerase II (PubMed:7638159, PubMed:8626763, PubMed:8846792).
Binding of TARBP1 and RNA polymerase II to HIV-1 TAR RNA is mutually exclusive, suggesting that TARBP1 may function alone or in conjunction with HIV-1 Tat to disengage RNA polymerase II from HIV-1 TAR RNA (PubMed:7638159, PubMed:8626763, PubMed:8846792).
3 PublicationsSites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 1566 | S-adenosyl-L-methionine; via amide nitrogen1 Publication | 1 | |
Binding sitei | 1600 | S-adenosyl-L-methionine1 Publication | 1 |
GO - Molecular functioni
- RNA binding Source: ProtInc
- tRNA (guanine) methyltransferase activity Source: GO_Central
GO - Biological processi
- regulation of transcription by RNA polymerase II Source: ProtInc
- tRNA methylation Source: GO_Central
Keywordsi
Molecular function | Methyltransferase, RNA-binding, Transferase |
Ligand | S-adenosyl-L-methionine |
Enzyme and pathway databases
BRENDAi | 2.1.1.34, 2681 |
PathwayCommonsi | Q13395 |
SignaLinki | Q13395 |
Names & Taxonomyi
Protein namesi | Recommended name: Probable methyltransferase TARBP1 (EC:2.1.1.-)Alternative name(s): TAR RNA-binding protein 1 TAR RNA-binding protein of 185 kDa Short name: TRP-185 |
Gene namesi | Name:TARBP1 Synonyms:TRM3, TRP185 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:11568, TARBP1 |
MIMi | 605052, gene |
neXtProti | NX_Q13395 |
VEuPathDBi | HostDB:ENSG00000059588 |
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 6894 |
OpenTargetsi | ENSG00000059588 |
PharmGKBi | PA36333 |
Miscellaneous databases
Pharosi | Q13395, Tbio |
Chemistry databases
ChEMBLi | CHEMBL2807 |
Genetic variation databases
BioMutai | TARBP1 |
DMDMi | 74739787 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000273201 | 1 – 1621 | Probable methyltransferase TARBP1Add BLAST | 1621 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 1 | N-acetylmethionineCombined sources | 1 | |
Modified residuei | 1442 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
EPDi | Q13395 |
jPOSTi | Q13395 |
MassIVEi | Q13395 |
MaxQBi | Q13395 |
PaxDbi | Q13395 |
PeptideAtlasi | Q13395 |
PRIDEi | Q13395 |
ProteomicsDBi | 59365 |
PTM databases
iPTMneti | Q13395 |
PhosphoSitePlusi | Q13395 |
Expressioni
Gene expression databases
Bgeei | ENSG00000059588, Expressed in right hemisphere of cerebellum and 241 other tissues |
Genevisiblei | Q13395, HS |
Organism-specific databases
HPAi | ENSG00000059588, Low tissue specificity |
Interactioni
Subunit structurei
Monomer and homodimer.
2 PublicationsProtein-protein interaction databases
BioGRIDi | 112757, 70 interactors |
IntActi | Q13395, 30 interactors |
STRINGi | 9606.ENSP00000040877 |
Miscellaneous databases
RNActi | Q13395, protein |
Structurei
Secondary structure
3D structure databases
SMRi | Q13395 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q13395 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1543 – 1545 | S-adenosyl-L-methionine binding1 Publication | 3 | |
Regioni | 1586 – 1595 | S-adenosyl-L-methionine binding1 Publication | 10 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG0839, Eukaryota |
GeneTreei | ENSGT00390000003939 |
HOGENOMi | CLU_002618_1_1_1 |
InParanoidi | Q13395 |
OMAi | NTQLTFW |
OrthoDBi | 171334at2759 |
PhylomeDBi | Q13395 |
TreeFami | TF314976 |
Family and domain databases
CDDi | cd18091, SpoU-like_TRM3-like, 1 hit |
Gene3Di | 3.40.1280.10, 1 hit |
InterProi | View protein in InterPro IPR029028, Alpha/beta_knot_MTases IPR016024, ARM-type_fold IPR025806, Prob_MeTrfase_TARBP1 IPR001537, SpoU_MeTrfase IPR045330, Trm3/TARBP1 IPR044748, Trm3/TARBP1_C IPR029026, tRNA_m1G_MTases_N |
PANTHERi | PTHR12029, PTHR12029, 1 hit |
Pfami | View protein in Pfam PF00588, SpoU_methylase, 1 hit |
SUPFAMi | SSF48371, SSF48371, 1 hit SSF75217, SSF75217, 1 hit |
i Sequence
Sequence statusi: Complete.
10 20 30 40 50
MEWVLAEALL SQSRDPRALL GALCQGEASA ERVETLRFLL QRLEDEEARG
60 70 80 90 100
SGGAGALPEA AREVAAGYLV PLLRSLRGRP AGGPDPSLQP RHRRRVLRAA
110 120 130 140 150
GAALRSCVRL AGRPQLAAAL AEEALRDLLA GWRAPGAEAA VEVLAAVGPC
160 170 180 190 200
LRPREDGPLL ERVAGTAVAL ALGGGGDGDE AGPAEDAAAL VAGRLLPVLV
210 220 230 240 250
QCGGAALRAV WGGLAAPGAS LGSGRVEEKL LVLSALAEKL LPEPGGDRAR
260 270 280 290 300
GAREAGPDAR RCWRFWRTVQ AGLGQADALT RKRARYLLQR AVEVSAELGA
310 320 330 340 350
DCTCGPQEGN GPSLFWWSER KKDELLKFWE NYILIMETLE GNQIHVIKPV
360 370 380 390 400
LPKLNNLFEY AVSEENGCWL FHPSWHMCIY KRMFESENKI LSKEGVIHFL
410 420 430 440 450
ELYETKILPF SPEFSEFIIG PLMDALSESS LYSRSPGQPI GSCSPLGLKL
460 470 480 490 500
QKFLVTYISL LPEEIKSSFL LKFIRKMTSR HWCAVPILFL SKALANVPRH
510 520 530 540 550
KALGIDGLLA LRDVIHCTMI THQILLRGAA QCYLLQTAMN LLDVEKVSLS
560 570 580 590 600
DVSTFLMSLR QEESLGRGTS LWTELCDWLR VNESYFKPSP TCSSIGLHKT
610 620 630 640 650
SLNAYVKSIV QEYVKSSAWE TGENCFMPDW FEAKLVSLMV LLAVDVEGMK
660 670 680 690 700
TQYSGKQRTE NVLRIFLDPL LDVLMKFSTN AYMPLLKTDR CLQLLLKLLN
710 720 730 740 750
TCRLKGSSAQ DDEVSTVLQN FFMSTTESIS EFILRRLTMN ELNSVSDLDR
760 770 780 790 800
CHLYLMVLTE LINLHLKVGW KRGNPIWRVI SLLKNASIQH LQEMDSGQEP
810 820 830 840 850
TVGSQIQRVV SMAALAMVCE AIDQKPELQL DSLHAGPLES FLSSLQLNQT
860 870 880 890 900
LQKPHAEEQS SYAHPLECSS VLEESSSSQG WGKIVAQYIH DQWVCLSFLL
910 920 930 940 950
KKYHTLIPTT GSEILEPFLP AVQMPIRTLQ SALEALTVLS SDQVLPVFHC
960 970 980 990 1000
LKVLVPKLLT SSESLCIESF DMAWKIISSL SNTQLIFWAN LKAFVQFVFD
1010 1020 1030 1040 1050
NKVLTIAAKI KGQAYFKIKE IMYKIIEMSA IKTGVFNTLI SYCCQSWIVS
1060 1070 1080 1090 1100
ASNVSQGSLS SAKNYSELIL EACIFGTVFR RDQRLVQDVQ TFIENLGHDC
1110 1120 1130 1140 1150
AANIVMENTK REDHYVRICA VKFLCLLDGS NMSHKLFIED LAIKLLDKDE
1160 1170 1180 1190 1200
LVSKSKKRYY VNSLQHRVKN RVWQTLLVLF PRLDQNFLNG IIDRIFQAGF
1210 1220 1230 1240 1250
TNNQASIKYF IEWIIILILH KFPQFLPKFW DCFSYGEENL KTSICTFLAV
1260 1270 1280 1290 1300
LSHLDIITQN IPEKKLILKQ ALIVVLQWCF NHNFSVRLYA LVALKKLWTV
1310 1320 1330 1340 1350
CKVLSVEEFD ALTPVIESSL HQVESMHGAG NAKKNWQRIQ EHFFFATFHP
1360 1370 1380 1390 1400
LKDYCLETIF YILPRLSGLI EDEWITIDKF TRFTDVPLAA GFQWYLSQTQ
1410 1420 1430 1440 1450
LSKLKPGDWS QQDIGTNLVE ADNQAEWTDV QKKIIPWNSR VSDLDLELLF
1460 1470 1480 1490 1500
QDRAARLGKS ISRLIVVASL IDKPTNLGGL CRTCEVFGAS VLVVGSLQCI
1510 1520 1530 1540 1550
SDKQFQHLSV SAEQWLPLVE VKPPQLIDYL QQKKTEGYTI IGVEQTAKSL
1560 1570 1580 1590 1600
DLTQYCFPEK SLLLLGNERE GIPANLIQQL DVCVEIPQQG IIRSLNVHVS
1610 1620
GALLIWEYTR QQLLSHGDTK P
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_030101 | 221 | L → P. Corresponds to variant dbSNP:rs12082990Ensembl. | 1 | |
Natural variantiVAR_030102 | 425 | A → T. Corresponds to variant dbSNP:rs10910439Ensembl. | 1 | |
Natural variantiVAR_061907 | 513 | D → G. Corresponds to variant dbSNP:rs35562024EnsemblClinVar. | 1 | |
Natural variantiVAR_030103 | 678 | S → G. Corresponds to variant dbSNP:rs4920246Ensembl. | 1 | |
Natural variantiVAR_030104 | 743 | N → S. Corresponds to variant dbSNP:rs2273872Ensembl. | 1 | |
Natural variantiVAR_030105 | 864 | H → P. Corresponds to variant dbSNP:rs4272658Ensembl. | 1 | |
Natural variantiVAR_030106 | 997 | F → L. Corresponds to variant dbSNP:rs12135427Ensembl. | 1 | |
Natural variantiVAR_030107 | 1038 | T → I. Corresponds to variant dbSNP:rs3820602Ensembl. | 1 | |
Natural variantiVAR_030108 | 1359 | I → V. Corresponds to variant dbSNP:rs3738616Ensembl. | 1 | |
Natural variantiVAR_030109 | 1461 | I → V. Corresponds to variant dbSNP:rs2275654Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U38847 mRNA Translation: AAC50379.1 AL136124 Genomic DNA No translation available. AL355472 Genomic DNA No translation available. |
CCDSi | CCDS1601.1 |
PIRi | S62356 |
RefSeqi | NP_005637.3, NM_005646.3 |
Genome annotation databases
Ensembli | ENST00000040877; ENSP00000040877; ENSG00000059588 |
GeneIDi | 6894 |
KEGGi | hsa:6894 |
MANE-Selecti | ENST00000040877.2; ENSP00000040877.1; NM_005646.4; NP_005637.3 |
UCSCi | uc001hwd.3, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U38847 mRNA Translation: AAC50379.1 AL136124 Genomic DNA No translation available. AL355472 Genomic DNA No translation available. |
CCDSi | CCDS1601.1 |
PIRi | S62356 |
RefSeqi | NP_005637.3, NM_005646.3 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2HA8 | X-ray | 1.60 | A/B | 1438-1621 | [»] | |
SMRi | Q13395 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 112757, 70 interactors |
IntActi | Q13395, 30 interactors |
STRINGi | 9606.ENSP00000040877 |
Chemistry databases
ChEMBLi | CHEMBL2807 |
PTM databases
iPTMneti | Q13395 |
PhosphoSitePlusi | Q13395 |
Genetic variation databases
BioMutai | TARBP1 |
DMDMi | 74739787 |
Proteomic databases
EPDi | Q13395 |
jPOSTi | Q13395 |
MassIVEi | Q13395 |
MaxQBi | Q13395 |
PaxDbi | Q13395 |
PeptideAtlasi | Q13395 |
PRIDEi | Q13395 |
ProteomicsDBi | 59365 |
Protocols and materials databases
Antibodypediai | 20805, 71 antibodies from 24 providers |
DNASUi | 6894 |
Genome annotation databases
Ensembli | ENST00000040877; ENSP00000040877; ENSG00000059588 |
GeneIDi | 6894 |
KEGGi | hsa:6894 |
MANE-Selecti | ENST00000040877.2; ENSP00000040877.1; NM_005646.4; NP_005637.3 |
UCSCi | uc001hwd.3, human |
Organism-specific databases
CTDi | 6894 |
DisGeNETi | 6894 |
GeneCardsi | TARBP1 |
HGNCi | HGNC:11568, TARBP1 |
HPAi | ENSG00000059588, Low tissue specificity |
MIMi | 605052, gene |
neXtProti | NX_Q13395 |
OpenTargetsi | ENSG00000059588 |
PharmGKBi | PA36333 |
VEuPathDBi | HostDB:ENSG00000059588 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0839, Eukaryota |
GeneTreei | ENSGT00390000003939 |
HOGENOMi | CLU_002618_1_1_1 |
InParanoidi | Q13395 |
OMAi | NTQLTFW |
OrthoDBi | 171334at2759 |
PhylomeDBi | Q13395 |
TreeFami | TF314976 |
Enzyme and pathway databases
BRENDAi | 2.1.1.34, 2681 |
PathwayCommonsi | Q13395 |
SignaLinki | Q13395 |
Miscellaneous databases
BioGRID-ORCSi | 6894, 15 hits in 1050 CRISPR screens |
ChiTaRSi | TARBP1, human |
EvolutionaryTracei | Q13395 |
GeneWikii | TARBP1 |
GenomeRNAii | 6894 |
Pharosi | Q13395, Tbio |
PROi | PR:Q13395 |
RNActi | Q13395, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000059588, Expressed in right hemisphere of cerebellum and 241 other tissues |
Genevisiblei | Q13395, HS |
Family and domain databases
CDDi | cd18091, SpoU-like_TRM3-like, 1 hit |
Gene3Di | 3.40.1280.10, 1 hit |
InterProi | View protein in InterPro IPR029028, Alpha/beta_knot_MTases IPR016024, ARM-type_fold IPR025806, Prob_MeTrfase_TARBP1 IPR001537, SpoU_MeTrfase IPR045330, Trm3/TARBP1 IPR044748, Trm3/TARBP1_C IPR029026, tRNA_m1G_MTases_N |
PANTHERi | PTHR12029, PTHR12029, 1 hit |
Pfami | View protein in Pfam PF00588, SpoU_methylase, 1 hit |
SUPFAMi | SSF48371, SSF48371, 1 hit SSF75217, SSF75217, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | TARB1_HUMAN | |
Accessioni | Q13395Primary (citable) accession number: Q13395 Secondary accession number(s): Q9H581 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 23, 2007 |
Last sequence update: | November 1, 1996 | |
Last modified: | February 23, 2022 | |
This is version 158 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families