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UniProtKB - Q13395 (TARB1_HUMAN)

Protein

Probable methyltransferase TARBP1

Gene

TARBP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Probable S-adenosyl-L-methionine-dependent methyltransferase which methylates RNA molecules such as tRNAs. In case of infection by HIV-1, it binds to the loop region of TAR RNA, a region also bound by RNA polymerase II. Binding of TARBP1 and RNA polymerase II to HIV-1 TAR RNA is mutually exclusive, suggesting that TARBP1 may function alone or in conjunction with HIV-1 Tat to disengage RNA polymerase II from HIV-1 TAR RNA. May act by methylating HIV-1 TAR RNA.3 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei1566S-adenosyl-L-methionine; via amide nitrogen1 Publication1
Binding sitei1600S-adenosyl-L-methionine1 Publication1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • RNA binding Source: ProtInc
  • tRNA (guanine) methyltransferase activity Source: GO_Central
View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionMethyltransferase, RNA-binding, Transferase
LigandS-adenosyl-L-methionine

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Probable methyltransferase TARBP1 (EC:2.1.1.-)
Alternative name(s):
TAR RNA-binding protein 1
TAR RNA-binding protein of 185 kDa
Short name:
TRP-185
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TARBP1
Synonyms:TRM3, TRP185
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000059588.9

Human Gene Nomenclature Database

More...HGNCi		HGNC:11568 TARBP1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		605052 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q13395

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		6894

Open Targets

More...OpenTargetsi		ENSG00000059588

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA36333

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		TARBP1

Domain mapping of disease mutations (DMDM)

More...DMDMi		74739787

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002732011 – 1621Probable methyltransferase TARBP1Add BLAST1621

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineCombined sources1
Modified residuei1442PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q13395

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q13395

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q13395

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q13395

PeptideAtlas

More...PeptideAtlasi		Q13395

PRoteomics IDEntifications database

More...PRIDEi		Q13395

ProteomicsDB human proteome resource

More...ProteomicsDBi		59365

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q13395

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q13395

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000059588 Expressed in 227 organ(s), highest expression level in right hemisphere of cerebellum

CleanEx database of gene expression profiles

More...CleanExi		HS_TARBP1

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q13395 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		CAB020810
HPA024632

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Monomer and homodimer.2 Publications

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		112757, 43 interactors

Protein interaction database and analysis system

More...IntActi		Q13395, 8 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000040877

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11621
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2HA8X-ray1.60A/B1438-1621[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...ProteinModelPortali		Q13395

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q13395

Database of comparative protein structure models

More...ModBasei		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		Q13395

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1543 – 1545S-adenosyl-L-methionine binding1 Publication3
Regioni1586 – 1595S-adenosyl-L-methionine binding1 Publication10

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi99 – 219Ala-richAdd BLAST121

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0839 Eukaryota
COG0566 LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00390000003939

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		HOG000154511

The HOVERGEN Database of Homologous Vertebrate Genes

More...HOVERGENi		HBG094026

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q13395

KEGG Orthology (KO)

More...KOi		K15333

Identification of Orthologs from Complete Genome Data

More...OMAi		WFEAKLV

Database of Orthologous Groups

More...OrthoDBi		171334at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q13395

TreeFam database of animal gene trees

More...TreeFami		TF314976

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.40.1280.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR029028 Alpha/beta_knot_MTases
IPR016024 ARM-type_fold
IPR025806 Prob_MeTrfase_TARBP1
IPR001537 SpoU_MeTrfase
IPR029026 tRNA_m1G_MTases_N

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00588 SpoU_methylase, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48371 SSF48371, 1 hit
SSF75217 SSF75217, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q13395-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEWVLAEALL SQSRDPRALL GALCQGEASA ERVETLRFLL QRLEDEEARG 
        60         70         80         90        100
SGGAGALPEA AREVAAGYLV PLLRSLRGRP AGGPDPSLQP RHRRRVLRAA 
       110        120        130        140        150
GAALRSCVRL AGRPQLAAAL AEEALRDLLA GWRAPGAEAA VEVLAAVGPC 
       160        170        180        190        200
LRPREDGPLL ERVAGTAVAL ALGGGGDGDE AGPAEDAAAL VAGRLLPVLV 
       210        220        230        240        250
QCGGAALRAV WGGLAAPGAS LGSGRVEEKL LVLSALAEKL LPEPGGDRAR 
       260        270        280        290        300
GAREAGPDAR RCWRFWRTVQ AGLGQADALT RKRARYLLQR AVEVSAELGA 
       310        320        330        340        350
DCTCGPQEGN GPSLFWWSER KKDELLKFWE NYILIMETLE GNQIHVIKPV 
       360        370        380        390        400
LPKLNNLFEY AVSEENGCWL FHPSWHMCIY KRMFESENKI LSKEGVIHFL 
       410        420        430        440        450
ELYETKILPF SPEFSEFIIG PLMDALSESS LYSRSPGQPI GSCSPLGLKL 
       460        470        480        490        500
QKFLVTYISL LPEEIKSSFL LKFIRKMTSR HWCAVPILFL SKALANVPRH 
       510        520        530        540        550
KALGIDGLLA LRDVIHCTMI THQILLRGAA QCYLLQTAMN LLDVEKVSLS 
       560        570        580        590        600
DVSTFLMSLR QEESLGRGTS LWTELCDWLR VNESYFKPSP TCSSIGLHKT 
       610        620        630        640        650
SLNAYVKSIV QEYVKSSAWE TGENCFMPDW FEAKLVSLMV LLAVDVEGMK 
       660        670        680        690        700
TQYSGKQRTE NVLRIFLDPL LDVLMKFSTN AYMPLLKTDR CLQLLLKLLN 
       710        720        730        740        750
TCRLKGSSAQ DDEVSTVLQN FFMSTTESIS EFILRRLTMN ELNSVSDLDR 
       760        770        780        790        800
CHLYLMVLTE LINLHLKVGW KRGNPIWRVI SLLKNASIQH LQEMDSGQEP 
       810        820        830        840        850
TVGSQIQRVV SMAALAMVCE AIDQKPELQL DSLHAGPLES FLSSLQLNQT 
       860        870        880        890        900
LQKPHAEEQS SYAHPLECSS VLEESSSSQG WGKIVAQYIH DQWVCLSFLL 
       910        920        930        940        950
KKYHTLIPTT GSEILEPFLP AVQMPIRTLQ SALEALTVLS SDQVLPVFHC 
       960        970        980        990       1000
LKVLVPKLLT SSESLCIESF DMAWKIISSL SNTQLIFWAN LKAFVQFVFD 
      1010       1020       1030       1040       1050
NKVLTIAAKI KGQAYFKIKE IMYKIIEMSA IKTGVFNTLI SYCCQSWIVS 
      1060       1070       1080       1090       1100
ASNVSQGSLS SAKNYSELIL EACIFGTVFR RDQRLVQDVQ TFIENLGHDC 
      1110       1120       1130       1140       1150
AANIVMENTK REDHYVRICA VKFLCLLDGS NMSHKLFIED LAIKLLDKDE 
      1160       1170       1180       1190       1200
LVSKSKKRYY VNSLQHRVKN RVWQTLLVLF PRLDQNFLNG IIDRIFQAGF 
      1210       1220       1230       1240       1250
TNNQASIKYF IEWIIILILH KFPQFLPKFW DCFSYGEENL KTSICTFLAV 
      1260       1270       1280       1290       1300
LSHLDIITQN IPEKKLILKQ ALIVVLQWCF NHNFSVRLYA LVALKKLWTV 
      1310       1320       1330       1340       1350
CKVLSVEEFD ALTPVIESSL HQVESMHGAG NAKKNWQRIQ EHFFFATFHP 
      1360       1370       1380       1390       1400
LKDYCLETIF YILPRLSGLI EDEWITIDKF TRFTDVPLAA GFQWYLSQTQ 
      1410       1420       1430       1440       1450
LSKLKPGDWS QQDIGTNLVE ADNQAEWTDV QKKIIPWNSR VSDLDLELLF 
      1460       1470       1480       1490       1500
QDRAARLGKS ISRLIVVASL IDKPTNLGGL CRTCEVFGAS VLVVGSLQCI 
      1510       1520       1530       1540       1550
SDKQFQHLSV SAEQWLPLVE VKPPQLIDYL QQKKTEGYTI IGVEQTAKSL 
      1560       1570       1580       1590       1600
DLTQYCFPEK SLLLLGNERE GIPANLIQQL DVCVEIPQQG IIRSLNVHVS 
      1610       1620 
GALLIWEYTR QQLLSHGDTK P
Length:1,621
Mass (Da):181,675
Last modified:November 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA8C2BC62B7F1ADA8
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_030101221L → P. Corresponds to variant dbSNP:rs12082990Ensembl.1
Natural variantiVAR_030102425A → T. Corresponds to variant dbSNP:rs10910439Ensembl.1
Natural variantiVAR_061907513D → G. Corresponds to variant dbSNP:rs35562024Ensembl.1
Natural variantiVAR_030103678S → G. Corresponds to variant dbSNP:rs4920246Ensembl.1
Natural variantiVAR_030104743N → S. Corresponds to variant dbSNP:rs2273872Ensembl.1
Natural variantiVAR_030105864H → P. Corresponds to variant dbSNP:rs4272658Ensembl.1
Natural variantiVAR_030106997F → L. Corresponds to variant dbSNP:rs12135427Ensembl.1
Natural variantiVAR_0301071038T → I. Corresponds to variant dbSNP:rs3820602Ensembl.1
Natural variantiVAR_0301081359I → V. Corresponds to variant dbSNP:rs3738616Ensembl.1
Natural variantiVAR_0301091461I → V. Corresponds to variant dbSNP:rs2275654Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
U38847 mRNA Translation: AAC50379.1
AL136124 Genomic DNA No translation available.
AL355472 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS1601.1

Protein sequence database of the Protein Information Resource

More...PIRi		S62356

NCBI Reference Sequences

More...RefSeqi		NP_005637.3, NM_005646.3

UniGene gene-oriented nucleotide sequence clusters

More...UniGenei		Hs.498115

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000040877; ENSP00000040877; ENSG00000059588

Database of genes from NCBI RefSeq genomes

More...GeneIDi		6894

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:6894

UCSC genome browser

More...UCSCi		uc001hwd.3 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U38847 mRNA Translation: AAC50379.1
AL136124 Genomic DNA No translation available.
AL355472 Genomic DNA No translation available.
CCDSiCCDS1601.1
PIRiS62356
RefSeqiNP_005637.3, NM_005646.3
UniGeneiHs.498115

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2HA8X-ray1.60A/B1438-1621[»]
ProteinModelPortaliQ13395
SMRiQ13395
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112757, 43 interactors
IntActiQ13395, 8 interactors
STRINGi9606.ENSP00000040877

PTM databases

iPTMnetiQ13395
PhosphoSitePlusiQ13395

Polymorphism and mutation databases

BioMutaiTARBP1
DMDMi74739787

Proteomic databases

EPDiQ13395
jPOSTiQ13395
MaxQBiQ13395
PaxDbiQ13395
PeptideAtlasiQ13395
PRIDEiQ13395
ProteomicsDBi59365

Protocols and materials databases

The DNASU plasmid repository

More...DNASUi		6894
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000040877; ENSP00000040877; ENSG00000059588
GeneIDi6894
KEGGihsa:6894
UCSCiuc001hwd.3 human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		6894
DisGeNETi6894
EuPathDBiHostDB:ENSG00000059588.9

GeneCards: human genes, protein and diseases

More...GeneCardsi		TARBP1
HGNCiHGNC:11568 TARBP1
HPAiCAB020810
HPA024632
MIMi605052 gene
neXtProtiNX_Q13395
OpenTargetsiENSG00000059588
PharmGKBiPA36333

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0839 Eukaryota
COG0566 LUCA
GeneTreeiENSGT00390000003939
HOGENOMiHOG000154511
HOVERGENiHBG094026
InParanoidiQ13395
KOiK15333
OMAiWFEAKLV
OrthoDBi171334at2759
PhylomeDBiQ13395
TreeFamiTF314976

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		TARBP1 human
EvolutionaryTraceiQ13395

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		TARBP1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		6894

Protein Ontology

More...PROi		PR:Q13395

The Stanford Online Universal Resource for Clones and ESTs

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Gene expression databases

BgeeiENSG00000059588 Expressed in 227 organ(s), highest expression level in right hemisphere of cerebellum
CleanExiHS_TARBP1
GenevisibleiQ13395 HS

Family and domain databases

Gene3Di3.40.1280.10, 1 hit
InterProiView protein in InterPro
IPR029028 Alpha/beta_knot_MTases
IPR016024 ARM-type_fold
IPR025806 Prob_MeTrfase_TARBP1
IPR001537 SpoU_MeTrfase
IPR029026 tRNA_m1G_MTases_N
PfamiView protein in Pfam
PF00588 SpoU_methylase, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit
SSF75217 SSF75217, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTARB1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q13395
Secondary accession number(s): Q9H581
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: November 1, 1996
Last modified: January 16, 2019
This is version 142 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
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