UniProtKB - Q13387 (JIP2_HUMAN)
C-Jun-amino-terminal kinase-interacting protein 2
MAPK8IP2
Functioni
The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. JIP2 inhibits IL1 beta-induced apoptosis in insulin-secreting cells. May function as a regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins (By similarity).
By similarityGO - Molecular functioni
- amyloid-beta binding Source: UniProtKB
- kinesin binding Source: UniProtKB
- MAP-kinase scaffold activity Source: UniProtKB
- protein-containing complex binding Source: Ensembl
- protein kinase activator activity Source: MGI
- protein kinase binding Source: UniProtKB
- structural molecule activity Source: ProtInc
GO - Biological processi
- behavioral fear response Source: BHF-UCL
- dendrite morphogenesis Source: BHF-UCL
- excitatory postsynaptic potential Source: BHF-UCL
- JNK cascade Source: Ensembl
- MAPK cascade Source: MGI
- mating behavior Source: Ensembl
- negative regulation of apoptotic signaling pathway Source: UniProtKB
- nonassociative learning Source: BHF-UCL
- positive regulation of stress-activated MAPK cascade Source: Ensembl
- regulation of AMPA receptor activity Source: BHF-UCL
- regulation of JNK cascade Source: UniProtKB
- regulation of NMDA receptor activity Source: BHF-UCL
- regulation of signaling receptor activity Source: BHF-UCL
- regulation of synaptic transmission, glutamatergic Source: BHF-UCL
- signal complex assembly Source: ProtInc
- social behavior Source: BHF-UCL
Enzyme and pathway databases
PathwayCommonsi | Q13387 |
SignaLinki | Q13387 |
SIGNORi | Q13387 |
Protein family/group databases
MoonDBi | Q13387, Predicted |
Names & Taxonomyi
Protein namesi | Recommended name: C-Jun-amino-terminal kinase-interacting protein 2Short name: JIP-2 Short name: JNK-interacting protein 2 Alternative name(s): Islet-brain-2 Short name: IB-2 JNK MAP kinase scaffold protein 2 Mitogen-activated protein kinase 8-interacting protein 2 |
Gene namesi | Name:MAPK8IP2 Synonyms:IB2, JIP2, PRKM8IPL |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:6883, MAPK8IP2 |
MIMi | 607755, gene |
neXtProti | NX_Q13387 |
VEuPathDBi | HostDB:ENSG00000008735 |
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm 1 Publication
Note: Accumulates in cell surface projections.1 Publication
Other locations
- cytoplasm Source: UniProtKB
- neuronal cell body Source: Ensembl
- postsynaptic density Source: BHF-UCL
- protein-containing complex Source: Ensembl
Keywords - Cellular componenti
CytoplasmPathology & Biotechi
Organism-specific databases
DisGeNETi | 23542 |
OpenTargetsi | ENSG00000008735 |
PharmGKBi | PA30627 |
Miscellaneous databases
Pharosi | Q13387, Tbio |
Genetic variation databases
BioMutai | MAPK8IP2 |
DMDMi | 17433017 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000220631 | 1 – 824 | C-Jun-amino-terminal kinase-interacting protein 2Add BLAST | 824 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 254 | PhosphoserineBy similarity | 1 | |
Modified residuei | 302 | PhosphoserineBy similarity | 1 | |
Modified residuei | 305 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
MassIVEi | Q13387 |
PaxDbi | Q13387 |
PeptideAtlasi | Q13387 |
PRIDEi | Q13387 |
ProteomicsDBi | 59356 [Q13387-1] 59357 [Q13387-2] 59358 [Q13387-3] 59359 [Q13387-4] |
PTM databases
iPTMneti | Q13387 |
PhosphoSitePlusi | Q13387 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000008735, Expressed in anterior cingulate cortex and 196 other tissues |
Genevisiblei | Q13387, HS |
Organism-specific databases
HPAi | ENSG00000008735, Group enriched (brain, pituitary gland) |
Interactioni
Subunit structurei
Forms homo- or heterooligomeric complexes. Binds specific components of the JNK signaling pathway namely JNK1, JNK2, JNK3, MAP2K7, MAP3K10, MAP3K11, MAP3K12 and MAPK13. Also binds the proline-rich domain-containing splice variant of apolipoprotein E receptor 2 (ApoER2). Binds the cytoplasmic tails of LRP1 and LRP2 (Megalin). Binds the TPR motif-containing C-terminal of kinesin light chain, Klc1, pre-assembled MAPK8IP1 scaffolding complexes are then transported as a cargo of kinesin, to the required subcellular location (By similarity).
Interacts with the cytoplasmic domain of APP (By similarity).
Interacts with DCLK2.
Interacts with TIAM1 and TIAM2 (By similarity).
Interacts with FGF13; enables the interaction with MAPK13 and may regulate the MAPK8IP2 scaffolding activity.
Interacts with SH3RF2 (By similarity).
By similarity2 PublicationsBinary interactionsi
Q13387
Isoform 4 [Q13387-4]
GO - Molecular functioni
- kinesin binding Source: UniProtKB
- protein kinase binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 117086, 108 interactors |
CORUMi | Q13387 |
IntActi | Q13387, 84 interactors |
MINTi | Q13387 |
STRINGi | 9606.ENSP00000330572 |
Miscellaneous databases
RNActi | Q13387, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 604 – 665 | SH3PROSITE-ProRule annotationAdd BLAST | 62 | |
Domaini | 677 – 813 | PIDPROSITE-ProRule annotationAdd BLAST | 137 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 28 | DisorderedSequence analysisAdd BLAST | 28 | |
Regioni | 40 – 160 | DisorderedSequence analysisAdd BLAST | 121 | |
Regioni | 110 – 275 | JNK-binding domain (JBD)Add BLAST | 166 | |
Regioni | 172 – 349 | DisorderedSequence analysisAdd BLAST | 178 | |
Regioni | 239 – 498 | Necessary for interaction with FGF131 PublicationAdd BLAST | 260 | |
Regioni | 361 – 501 | DisorderedSequence analysisAdd BLAST | 141 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 49 – 63 | Basic and acidic residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 79 – 110 | Acidic residuesSequence analysisAdd BLAST | 32 | |
Compositional biasi | 142 – 160 | Polar residuesSequence analysisAdd BLAST | 19 | |
Compositional biasi | 239 – 254 | Polar residuesSequence analysisAdd BLAST | 16 | |
Compositional biasi | 272 – 302 | Polar residuesSequence analysisAdd BLAST | 31 | |
Compositional biasi | 415 – 434 | Pro residuesSequence analysisAdd BLAST | 20 | |
Compositional biasi | 468 – 484 | Acidic residuesSequence analysisAdd BLAST | 17 |
Sequence similaritiesi
Keywords - Domaini
SH3 domainPhylogenomic databases
eggNOGi | KOG3775, Eukaryota |
GeneTreei | ENSGT00940000160461 |
HOGENOMi | CLU_006711_0_0_1 |
InParanoidi | Q13387 |
OMAi | CEGNRPA |
OrthoDBi | 372907at2759 |
PhylomeDBi | Q13387 |
Family and domain databases
CDDi | cd11942, SH3_JIP2, 1 hit |
Gene3Di | 2.30.29.30, 1 hit |
InterProi | View protein in InterPro IPR035637, JIP2_SH3 IPR011993, PH-like_dom_sf IPR006020, PTB/PI_dom IPR001452, SH3_domain |
Pfami | View protein in Pfam PF00640, PID, 1 hit PF14604, SH3_9, 1 hit |
SMARTi | View protein in SMART SM00462, PTB, 1 hit SM00326, SH3, 1 hit |
PROSITEi | View protein in PROSITE PS01179, PID, 1 hit PS50002, SH3, 1 hit |
s (4)i Sequence
Sequence statusi: Complete.
This entry describes 4 produced by isoformsialternative splicing. AlignAdd to basketThis isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MADRAEMFSL STFHSLSPPG CRPPQDISLE EFDDEDLSEI TDDCGLGLSY
60 70 80 90 100
DSDHCEKDSL SLGRSEQPHP ICSFQDDFQE FEMIDDNEEE DDEDEEEEEE
110 120 130 140 150
EEEGDGEGQE GGDPGSEAPA PGPLIPSPSV EEPHKHRPTT LRLTTLGAQD
160 170 180 190 200
SLNNNGGFDL VRPASWQETA LCSPAPEALR ELPGPLPATD TGPGGAQSPV
210 220 230 240 250
RPGCDCEGNR PAEPPAPGGT SPSSDPGIEA DLRSRSSGGR GGRRSSQELS
260 270 280 290 300
SPGSDSEDAG GARLGRMISS ISETELELSS DGGSSSSGRS SHLTNSIEEA
310 320 330 340 350
SSPASEPEPP REPPRRPAFL PVGPDDTNSE YESGSESEPD LSEDADSPWL
360 370 380 390 400
LSNLVSRMIS EGSSPIRCPG QCLSPAPRPP GEPVSPAGGA AQDSQDPEAA
410 420 430 440 450
AGPGGVELVD METLCAPPPP APAAPRPGPA QPGPCLFLSN PTRDTITPLW
460 470 480 490 500
AAPGRAARPG RACSAACSEE EDEEDDEEEE DAEDSAGSPG GRGTGPSAPR
510 520 530 540 550
DASLVYDAVK YTLVVDEHTQ LELVSLRRCA GLGHDSEEDS GGEASEEEAG
560 570 580 590 600
AALLGGGQVS GDTSPDSPDL TFSKKFLNVF VNSTSRSSST ESFGLFSCLV
610 620 630 640 650
NGEEREQTHR AVFRFIPRHP DELELDVDDP VLVEAEEDDF WFRGFNMRTG
660 670 680 690 700
ERGVFPAFYA HAVPGPAKDL LGSKRSPCWV ERFDVQFLGS VEVPCHQGNG
710 720 730 740 750
ILCAAMQKIA TARKLTVHLR PPASCDLEIS LRGVKLSLSG GGPEFQRCSH
760 770 780 790 800
FFQMKNISFC GCHPRNSCYF GFITKHPLLS RFACHVFVSQ ESMRPVAQSV
810 820
GRAFLEYYQE HLAYACPTED IYLE
The sequence of this isoform differs from the canonical sequence as follows:
1-57: MADRAEMFSL...LSYDSDHCEK → MLPDFPSPSTWAPGLLLPSGPALLSPSVLQ
152-394: Missing.
415-439: Missing.
768-768: C → CEAPQGAAFQWERGVDRKRVLQTRGNVQPHLGAGQGAALNRATEGSSTGSEKGEWTPLVIMELTQSVNSC
Sequence cautioni
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_049666 | 743 | P → L. Corresponds to variant dbSNP:rs1140555Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_002770 | 1 – 57 | MADRA…DHCEK → MLPDFPSPSTWAPGLLLPSG PALLSPSVLQ in isoform 2 and isoform 3. 1 PublicationAdd BLAST | 57 | |
Alternative sequenceiVSP_002771 | 88 – 468 | Missing in isoform 4. 1 PublicationAdd BLAST | 381 | |
Alternative sequenceiVSP_002772 | 152 – 394 | Missing in isoform 3. CuratedAdd BLAST | 243 | |
Alternative sequenceiVSP_002773 | 415 – 439 | Missing in isoform 3. CuratedAdd BLAST | 25 | |
Alternative sequenceiVSP_002774 | 768 | C → CEAPQGAAFQWERGVDRKRV LQTRGNVQPHLGAGQGAALN RATEGSSTGSEKGEWTPLVI MELTQSVNSC in isoform 3. Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF136382 mRNA Translation: AAF00980.1 AF218778 mRNA Translation: AAF32323.1 U62317 Genomic DNA Translation: AAB03340.1 BC009940 mRNA Translation: AAH09940.2 AL021708 mRNA Translation: CAA16714.1 Different initiation. U79261 mRNA Translation: AAB50207.1 |
CCDSi | CCDS74886.1 [Q13387-1] |
RefSeqi | NP_036456.1, NM_012324.4 [Q13387-1] |
Genome annotation databases
Ensembli | ENST00000329492; ENSP00000330572; ENSG00000008735 |
GeneIDi | 23542 |
KEGGi | hsa:23542 |
MANE-Selecti | ENST00000329492.6; ENSP00000330572.4; NM_012324.6; NP_036456.1 |
UCSCi | uc032qrw.2, human [Q13387-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF136382 mRNA Translation: AAF00980.1 AF218778 mRNA Translation: AAF32323.1 U62317 Genomic DNA Translation: AAB03340.1 BC009940 mRNA Translation: AAH09940.2 AL021708 mRNA Translation: CAA16714.1 Different initiation. U79261 mRNA Translation: AAB50207.1 |
CCDSi | CCDS74886.1 [Q13387-1] |
RefSeqi | NP_036456.1, NM_012324.4 [Q13387-1] |
3D structure databases
SMRi | Q13387 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 117086, 108 interactors |
CORUMi | Q13387 |
IntActi | Q13387, 84 interactors |
MINTi | Q13387 |
STRINGi | 9606.ENSP00000330572 |
Protein family/group databases
MoonDBi | Q13387, Predicted |
PTM databases
iPTMneti | Q13387 |
PhosphoSitePlusi | Q13387 |
Genetic variation databases
BioMutai | MAPK8IP2 |
DMDMi | 17433017 |
Proteomic databases
MassIVEi | Q13387 |
PaxDbi | Q13387 |
PeptideAtlasi | Q13387 |
PRIDEi | Q13387 |
ProteomicsDBi | 59356 [Q13387-1] 59357 [Q13387-2] 59358 [Q13387-3] 59359 [Q13387-4] |
Protocols and materials databases
Antibodypediai | 28835, 252 antibodies from 27 providers |
DNASUi | 23542 |
Genome annotation databases
Ensembli | ENST00000329492; ENSP00000330572; ENSG00000008735 |
GeneIDi | 23542 |
KEGGi | hsa:23542 |
MANE-Selecti | ENST00000329492.6; ENSP00000330572.4; NM_012324.6; NP_036456.1 |
UCSCi | uc032qrw.2, human [Q13387-1] |
Organism-specific databases
CTDi | 23542 |
DisGeNETi | 23542 |
GeneCardsi | MAPK8IP2 |
HGNCi | HGNC:6883, MAPK8IP2 |
HPAi | ENSG00000008735, Group enriched (brain, pituitary gland) |
MIMi | 607755, gene |
neXtProti | NX_Q13387 |
OpenTargetsi | ENSG00000008735 |
PharmGKBi | PA30627 |
VEuPathDBi | HostDB:ENSG00000008735 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3775, Eukaryota |
GeneTreei | ENSGT00940000160461 |
HOGENOMi | CLU_006711_0_0_1 |
InParanoidi | Q13387 |
OMAi | CEGNRPA |
OrthoDBi | 372907at2759 |
PhylomeDBi | Q13387 |
Enzyme and pathway databases
PathwayCommonsi | Q13387 |
SignaLinki | Q13387 |
SIGNORi | Q13387 |
Miscellaneous databases
BioGRID-ORCSi | 23542, 3 hits in 256 CRISPR screens |
ChiTaRSi | MAPK8IP2, human |
GeneWikii | MAPK8IP2 |
GenomeRNAii | 23542 |
Pharosi | Q13387, Tbio |
PROi | PR:Q13387 |
RNActi | Q13387, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000008735, Expressed in anterior cingulate cortex and 196 other tissues |
Genevisiblei | Q13387, HS |
Family and domain databases
CDDi | cd11942, SH3_JIP2, 1 hit |
Gene3Di | 2.30.29.30, 1 hit |
InterProi | View protein in InterPro IPR035637, JIP2_SH3 IPR011993, PH-like_dom_sf IPR006020, PTB/PI_dom IPR001452, SH3_domain |
Pfami | View protein in Pfam PF00640, PID, 1 hit PF14604, SH3_9, 1 hit |
SMARTi | View protein in SMART SM00462, PTB, 1 hit SM00326, SH3, 1 hit |
PROSITEi | View protein in PROSITE PS01179, PID, 1 hit PS50002, SH3, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | JIP2_HUMAN | |
Accessioni | Q13387Primary (citable) accession number: Q13387 Secondary accession number(s): Q96G62 Q9UKQ4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 5, 2001 |
Last sequence update: | December 5, 2001 | |
Last modified: | February 23, 2022 | |
This is version 182 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 22
Human chromosome 22: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families