UniProtKB - Q13387 (JIP2_HUMAN)

BLAST

>sp|Q13387|JIP2_HUMAN C-Jun-amino-terminal kinase-interacting protein 2 OS=Homo sapiens OX=9606 GN=MAPK8IP2 PE=1 SV=2
MADRAEMFSLSTFHSLSPPGCRPPQDISLEEFDDEDLSEITDDCGLGLSYDSDHCEKDSL
SLGRSEQPHPICSFQDDFQEFEMIDDNEEEDDEDEEEEEEEEEGDGEGQEGGDPGSEAPA
PGPLIPSPSVEEPHKHRPTTLRLTTLGAQDSLNNNGGFDLVRPASWQETALCSPAPEALR
ELPGPLPATDTGPGGAQSPVRPGCDCEGNRPAEPPAPGGTSPSSDPGIEADLRSRSSGGR
GGRRSSQELSSPGSDSEDAGGARLGRMISSISETELELSSDGGSSSSGRSSHLTNSIEEA
SSPASEPEPPREPPRRPAFLPVGPDDTNSEYESGSESEPDLSEDADSPWLLSNLVSRMIS
EGSSPIRCPGQCLSPAPRPPGEPVSPAGGAAQDSQDPEAAAGPGGVELVDMETLCAPPPP
APAAPRPGPAQPGPCLFLSNPTRDTITPLWAAPGRAARPGRACSAACSEEEDEEDDEEEE
DAEDSAGSPGGRGTGPSAPRDASLVYDAVKYTLVVDEHTQLELVSLRRCAGLGHDSEEDS
GGEASEEEAGAALLGGGQVSGDTSPDSPDLTFSKKFLNVFVNSTSRSSSTESFGLFSCLV
NGEEREQTHRAVFRFIPRHPDELELDVDDPVLVEAEEDDFWFRGFNMRTGERGVFPAFYA
HAVPGPAKDLLGSKRSPCWVERFDVQFLGSVEVPCHQGNGILCAAMQKIATARKLTVHLR
PPASCDLEISLRGVKLSLSGGGPEFQRCSHFFQMKNISFCGCHPRNSCYFGFITKHPLLS
RFACHVFVSQESMRPVAQSVGRAFLEYYQEHLAYACPTEDIYLE

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Format
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History
Entry version 163 (12 Sep 2018)
Sequence version 2 (05 Dec 2001)
Previous versions | rss
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Protein

C-Jun-amino-terminal kinase-interacting protein 2

Gene

MAPK8IP2

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. JIP2 inhibits IL1 beta-induced apoptosis in insulin-secreting cells. May function as a regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins (By similarity).By similarity

GO - Molecular functionⁱ

amyloid-beta binding
Source: UniProtKB
Non-traceable author statementⁱ
- 12023290
kinesin binding Source: UniProtKB
MAP-kinase scaffold activity
Source: UniProtKB
Inferred from direct assayⁱ
- 10756100
protein-containing complex binding Source: Ensembl
protein kinase activator activity
Source: MGI
Inferred from direct assayⁱ
- 12244047
protein kinase binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 10490659
structural molecule activity
Source: ProtInc
Traceable author statementⁱ
- 10490659

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

behavioral fear response Source: BHF-UCL
dendrite morphogenesis Source: BHF-UCL
excitatory postsynaptic potential Source: BHF-UCL
JNK cascade Source: Ensembl
MAPK cascade
Source: MGI
Inferred from direct assayⁱ
- 12244047
mating behavior Source: Ensembl
negative regulation of apoptotic signaling pathway
Source: UniProtKB
Inferred from direct assayⁱ
- 10756100
nonassociative learning Source: BHF-UCL
positive regulation of stress-activated MAPK cascade Source: Ensembl
regulation of AMPA receptor activity Source: BHF-UCL
regulation of JNK cascade
Source: UniProtKB
Inferred from direct assayⁱ
- 10490659
regulation of NMDA receptor activity Source: BHF-UCL
regulation of signaling receptor activity Source: BHF-UCL
regulation of synaptic transmission, glutamatergic Source: BHF-UCL
signal complex assembly
Source: ProtInc
Traceable author statementⁱ
- 10490659
social behavior Source: BHF-UCL

View the complete GO annotation on QuickGO ...

Enzyme and pathway databases

SignaLinkⁱ	Q13387
SIGNORⁱ	Q13387

Protein family/group databases

MoonDBⁱ	Q13387 Predicted

MoonDBⁱ

Q13387 Predicted

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: C-Jun-amino-terminal kinase-interacting protein 2 Short name: JIP-2 Short name: JNK-interacting protein 2 Alternative name(s): Islet-brain-2 Short name: IB-2 JNK MAP kinase scaffold protein 2 Mitogen-activated protein kinase 8-interacting protein 2
Gene namesⁱ	Name:MAPK8IP2 Synonyms:IB2, JIP2, PRKM8IPL
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 22

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000008735.13
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:6883 MAPK8IP2
MIMⁱ	607755 gene
neXtProtⁱ	NX_Q13387

Keywords - Cellular componentⁱ

Cytoplasm

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	23542
Open Targets More...OpenTargetsⁱ	ENSG00000008735
PharmGKBⁱ	PA30627

Polymorphism and mutation databases

BioMutaⁱ	MAPK8IP2
DMDMⁱ	17433017

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000220631	1 – 824	C-Jun-amino-terminal kinase-interacting protein 2Add BLAST		824

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	254	PhosphoserineBy similarity	1
Modified residueⁱ	302	PhosphoserineBy similarity	1
Modified residueⁱ	305	PhosphoserineBy similarity	1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

PaxDbⁱ	Q13387
PeptideAtlas More...PeptideAtlasⁱ	Q13387
PRIDEⁱ	Q13387
ProteomicsDBⁱ	59356 59357 [Q13387-2] 59358 [Q13387-3] 59359 [Q13387-4]

PTM databases

iPTMnetⁱ	Q13387
PhosphoSitePlusⁱ	Q13387

Expressionⁱ

Tissue specificityⁱ

Expressed mainly in the brain and pancreas, including insulin-secreting cells. In the nervous system, more abundantly expressed in the cerebellum, pituitary gland, occipital lobe and the amygdala. Also expressed in fetal brain. Very low levels found in uterus, ovary, prostate, colon, testis, adrenal gland, thyroid gland and salivary gland.

Gene expression databases

Bgeeⁱ	ENSG00000008735 Expressed in 182 organ(s), highest expression level in anterior cingulate cortex
CleanExⁱ	HS_MAPK8IP2
Genevisibleⁱ	Q13387 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA034780

HPAⁱ

HPA034780

Interactionⁱ

Subunit structureⁱ

Forms homo- or heterooligomeric complexes. Binds specific components of the JNK signaling pathway namely JNK1, JNK2, JNK3, MAP2K7, MAP3K10, MAP3K11, MAP3K12 and MAPK13. Also binds the proline-rich domain-containing splice variant of apolipoprotein E receptor 2 (ApoER2). Binds the cytoplasmic tails of LRP1 and LRP2 (Megalin). Binds the TPR motif-containing C-terminal of kinesin light chain, Klc1, pre-assembled MAPK8IP1 scaffolding complexes are then transported as a cargo of kinesin, to the required subcellular location (By similarity). Interacts with the cytoplasmic domain of APP (By similarity). Interacts with DCLK2. Interacts with TIAM1 and TIAM2 (By similarity). Interacts with FGF13; enables the interaction with MAPK13 and may regulate the MAPK8IP2 scaffolding activity. Interacts with SH3RF2 (By similarity).By similarity2 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
	Q53HF2	2	EBI-722813,EBI-877761
ANGPT1	Q15389-2	3	EBI-722813,EBI-10692491
EGFR	P00533	4	EBI-722813,EBI-297353
ERBB2	P04626	3	EBI-722813,EBI-641062
UBD	O15205	3	EBI-722813,EBI-6657186

GO - Molecular functionⁱ

kinesin binding Source: UniProtKB
MAP-kinase scaffold activity
Source: UniProtKB
Inferred from direct assayⁱ
- 10756100
protein kinase binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 10490659

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	117086, 95 interactors
IntActⁱ	Q13387, 72 interactors
Molecular INTeraction database More...MINTⁱ	Q13387
STRINGⁱ	9606.ENSP00000330572

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q13387
SMRⁱ	Q13387
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	604 – 665	SH3PROSITE-ProRule annotationAdd BLAST		62
Domainⁱ	677 – 813	PIDPROSITE-ProRule annotationAdd BLAST		137

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	110 – 275	JNK-binding domain (JBD)Add BLAST		166
Regionⁱ	239 – 498	Necessary for interaction with FGF131 PublicationAdd BLAST		260

Compositional bias

Feature key	Position(s)	DescriptionActions	Length
Compositional biasⁱ	30 – 36	Asp/Glu-rich (acidic)	7
Compositional biasⁱ	85 – 103	Asp/Glu-rich (acidic)Add BLAST	19
Compositional biasⁱ	279 – 291	Ser-richAdd BLAST	13
Compositional biasⁱ	417 – 434	Pro-richAdd BLAST	18
Compositional biasⁱ	469 – 481	Asp/Glu-rich (acidic)Add BLAST	13

Sequence similaritiesⁱ

Belongs to the JIP scaffold family.Curated

Keywords - Domainⁱ

SH3 domain

Phylogenomic databases

eggNOGⁱ	KOG3775 Eukaryota ENOG410ZFRJ LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000003908
HOGENOMⁱ	HOG000231470
HOVERGENⁱ	HBG018568
InParanoidⁱ	Q13387
KEGG Orthology (KO) More...KOⁱ	K04435
OMAⁱ	HKHRPTT
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0T9G
PhylomeDBⁱ	Q13387

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd11942 SH3_JIP2, 1 hit
Gene3Dⁱ	2.30.29.30, 1 hit
InterProⁱ	View protein in InterPro IPR035637 JIP2_SH3 IPR011993 PH-like_dom_sf IPR006020 PTB/PI_dom IPR001452 SH3_domain
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00640 PID, 1 hit PF14604 SH3_9, 1 hit
SMARTⁱ	View protein in SMART SM00462 PTB, 1 hit SM00326 SH3, 1 hit
PROSITEⁱ	View protein in PROSITE PS01179 PID, 1 hit PS50002 SH3, 1 hit

Sequences (4)ⁱ

Sequence statusⁱ: Complete.

This entry describes 4 isoformsⁱ produced by alternative splicing. Align Add to basket

Note: Experimental confirmation may be lacking for some isoforms.

Isoform 1 (identifier: Q13387-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MADRAEMFSL STFHSLSPPG CRPPQDISLE EFDDEDLSEI TDDCGLGLSY 
        60         70         80         90        100
DSDHCEKDSL SLGRSEQPHP ICSFQDDFQE FEMIDDNEEE DDEDEEEEEE 
       110        120        130        140        150
EEEGDGEGQE GGDPGSEAPA PGPLIPSPSV EEPHKHRPTT LRLTTLGAQD 
       160        170        180        190        200
SLNNNGGFDL VRPASWQETA LCSPAPEALR ELPGPLPATD TGPGGAQSPV 
       210        220        230        240        250
RPGCDCEGNR PAEPPAPGGT SPSSDPGIEA DLRSRSSGGR GGRRSSQELS 
       260        270        280        290        300
SPGSDSEDAG GARLGRMISS ISETELELSS DGGSSSSGRS SHLTNSIEEA 
       310        320        330        340        350
SSPASEPEPP REPPRRPAFL PVGPDDTNSE YESGSESEPD LSEDADSPWL 
       360        370        380        390        400
LSNLVSRMIS EGSSPIRCPG QCLSPAPRPP GEPVSPAGGA AQDSQDPEAA 
       410        420        430        440        450
AGPGGVELVD METLCAPPPP APAAPRPGPA QPGPCLFLSN PTRDTITPLW 
       460        470        480        490        500
AAPGRAARPG RACSAACSEE EDEEDDEEEE DAEDSAGSPG GRGTGPSAPR 
       510        520        530        540        550
DASLVYDAVK YTLVVDEHTQ LELVSLRRCA GLGHDSEEDS GGEASEEEAG 
       560        570        580        590        600
AALLGGGQVS GDTSPDSPDL TFSKKFLNVF VNSTSRSSST ESFGLFSCLV 
       610        620        630        640        650
NGEEREQTHR AVFRFIPRHP DELELDVDDP VLVEAEEDDF WFRGFNMRTG 
       660        670        680        690        700
ERGVFPAFYA HAVPGPAKDL LGSKRSPCWV ERFDVQFLGS VEVPCHQGNG 
       710        720        730        740        750
ILCAAMQKIA TARKLTVHLR PPASCDLEIS LRGVKLSLSG GGPEFQRCSH 
       760        770        780        790        800
FFQMKNISFC GCHPRNSCYF GFITKHPLLS RFACHVFVSQ ESMRPVAQSV 
       810        820 
GRAFLEYYQE HLAYACPTED IYLE

Length:824

Mass (Da):87,975

Last modified:December 5, 2001 - v2

Checksum:ⁱ7EFC8F3BC58E37BB

Isoform 2 (identifier: Q13387-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-57: MADRAEMFSL...LSYDSDHCEK → MLPDFPSPSTWAPGLLLPSGPALLSPSVLQ

« Hide

        10         20         30         40         50
MLPDFPSPST WAPGLLLPSG PALLSPSVLQ DSLSLGRSEQ PHPICSFQDD 
        60         70         80         90        100
FQEFEMIDDN EEEDDEDEEE EEEEEEGDGE GQEGGDPGSE APAPGPLIPS 
       110        120        130        140        150
PSVEEPHKHR PTTLRLTTLG AQDSLNNNGG FDLVRPASWQ ETALCSPAPE 
       160        170        180        190        200
ALRELPGPLP ATDTGPGGAQ SPVRPGCDCE GNRPAEPPAP GGTSPSSDPG 
       210        220        230        240        250
IEADLRSRSS GGRGGRRSSQ ELSSPGSDSE DAGGARLGRM ISSISETELE 
       260        270        280        290        300
LSSDGGSSSS GRSSHLTNSI EEASSPASEP EPPREPPRRP AFLPVGPDDT 
       310        320        330        340        350
NSEYESGSES EPDLSEDADS PWLLSNLVSR MISEGSSPIR CPGQCLSPAP 
       360        370        380        390        400
RPPGEPVSPA GGAAQDSQDP EAAAGPGGVE LVDMETLCAP PPPAPAAPRP 
       410        420        430        440        450
GPAQPGPCLF LSNPTRDTIT PLWAAPGRAA RPGRACSAAC SEEEDEEDDE 
       460        470        480        490        500
EEEDAEDSAG SPGGRGTGPS APRDASLVYD AVKYTLVVDE HTQLELVSLR 
       510        520        530        540        550
RCAGLGHDSE EDSGGEASEE EAGAALLGGG QVSGDTSPDS PDLTFSKKFL 
       560        570        580        590        600
NVFVNSTSRS SSTESFGLFS CLVNGEEREQ THRAVFRFIP RHPDELELDV 
       610        620        630        640        650
DDPVLVEAEE DDFWFRGFNM RTGERGVFPA FYAHAVPGPA KDLLGSKRSP 
       660        670        680        690        700
CWVERFDVQF LGSVEVPCHQ GNGILCAAMQ KIATARKLTV HLRPPASCDL 
       710        720        730        740        750
EISLRGVKLS LSGGGPEFQR CSHFFQMKNI SFCGCHPRNS CYFGFITKHP 
       760        770        780        790 
LLSRFACHVF VSQESMRPVA QSVGRAFLEY YQEHLAYACP TEDIYLE

Show »

Length:797

Mass (Da):84,711

Checksum:ⁱ715D63743DF04E7B

Isoform 3 (identifier: Q13387-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-57: MADRAEMFSL...LSYDSDHCEK → MLPDFPSPSTWAPGLLLPSGPALLSPSVLQ
     152-394: Missing.
     415-439: Missing.
     768-768: C → CEAPQGAAFQWERGVDRKRVLQTRGNVQPHLGAGQGAALNRATEGSSTGSEKGEWTPLVIMELTQSVNSC

« Hide

        10         20         30         40         50
MLPDFPSPST WAPGLLLPSG PALLSPSVLQ DSLSLGRSEQ PHPICSFQDD 
        60         70         80         90        100
FQEFEMIDDN EEEDDEDEEE EEEEEEGDGE GQEGGDPGSE APAPGPLIPS 
       110        120        130        140        150
PSVEEPHKHR PTTLRLTTLG AQDSQDPEAA AGPGGVELVD METLNPTRDT 
       160        170        180        190        200
ITPLWAAPGR AARPGRACSA ACSEEEDEED DEEEEDAEDS AGSPGGRGTG 
       210        220        230        240        250
PSAPRDASLV YDAVKYTLVV DEHTQLELVS LRRCAGLGHD SEEDSGGEAS 
       260        270        280        290        300
EEEAGAALLG GGQVSGDTSP DSPDLTFSKK FLNVFVNSTS RSSSTESFGL 
       310        320        330        340        350
FSCLVNGEER EQTHRAVFRF IPRHPDELEL DVDDPVLVEA EEDDFWFRGF 
       360        370        380        390        400
NMRTGERGVF PAFYAHAVPG PAKDLLGSKR SPCWVERFDV QFLGSVEVPC 
       410        420        430        440        450
HQGNGILCAA MQKIATARKL TVHLRPPASC DLEISLRGVK LSLSGGGPEF 
       460        470        480        490        500
QRCSHFFQMK NISFCGCHPR NSCEAPQGAA FQWERGVDRK RVLQTRGNVQ 
       510        520        530        540        550
PHLGAGQGAA LNRATEGSST GSEKGEWTPL VIMELTQSVN SCYFGFITKH 
       560        570        580        590 
PLLSRFACHV FVSQESMRPV AQSVGRAFLE YYQEHLAYAC PTEDIYLE

Note: Might be artifactual as it is only predicted from a genomic sequence.

Show »

Length:598

Mass (Da):64,934

Checksum:ⁱ863EA918E833DCAE

Isoform 4 (identifier: Q13387-4) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
88-468: Missing.

« Hide

        10         20         30         40         50
MADRAEMFSL STFHSLSPPG CRPPQDISLE EFDDEDLSEI TDDCGLGLSY 
        60         70         80         90        100
DSDHCEKDSL SLGRSEQPHP ICSFQDDFQE FEMIDDNEEE DEEDDEEEED 
       110        120        130        140        150
AEDSAGSPGG RGTGPSAPRD ASLVYDAVKY TLVVDEHTQL ELVSLRRCAG 
       160        170        180        190        200
LGHDSEEDSG GEASEEEAGA ALLGGGQVSG DTSPDSPDLT FSKKFLNVFV 
       210        220        230        240        250
NSTSRSSSTE SFGLFSCLVN GEEREQTHRA VFRFIPRHPD ELELDVDDPV 
       260        270        280        290        300
LVEAEEDDFW FRGFNMRTGE RGVFPAFYAH AVPGPAKDLL GSKRSPCWVE 
       310        320        330        340        350
RFDVQFLGSV EVPCHQGNGI LCAAMQKIAT ARKLTVHLRP PASCDLEISL 
       360        370        380        390        400
RGVKLSLSGG GPEFQRCSHF FQMKNISFCG CHPRNSCYFG FITKHPLLSR 
       410        420        430        440 
FACHVFVSQE SMRPVAQSVG RAFLEYYQEH LAYACPTEDI YLE

Show »

Length:443

Mass (Da):49,070

Checksum:ⁱ6340E55966B6EFC3

Sequence cautionⁱ

The sequence CAA16714 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_049666	743	P → L. Corresponds to variant dbSNP:rs1140555Ensembl.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_002770	1 – 57	MADRA…DHCEK → MLPDFPSPSTWAPGLLLPSG PALLSPSVLQ in isoform 2 and isoform 3. 1 PublicationAdd BLAST	57
Alternative sequenceⁱVSP_002771	88 – 468	Missing in isoform 4. 1 PublicationAdd BLAST	381
Alternative sequenceⁱVSP_002772	152 – 394	Missing in isoform 3. CuratedAdd BLAST	243
Alternative sequenceⁱVSP_002773	415 – 439	Missing in isoform 3. CuratedAdd BLAST	25
Alternative sequenceⁱVSP_002774	768	C → CEAPQGAAFQWERGVDRKRV LQTRGNVQPHLGAGQGAALN RATEGSSTGSEKGEWTPLVI MELTQSVNSC in isoform 3. Curated	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF136382 mRNA Translation: AAF00980.1 AF218778 mRNA Translation: AAF32323.1 U62317 Genomic DNA Translation: AAB03340.1 BC009940 mRNA Translation: AAH09940.2 AL021708 mRNA Translation: CAA16714.1 Different initiation. U79261 mRNA Translation: AAB50207.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS74886.1 [Q13387-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_036456.1, NM_012324.4 [Q13387-1]
UniGeneⁱ	Hs.558180 Hs.656617

Genome annotation databases

Ensemblⁱ	ENST00000329492; ENSP00000330572; ENSG00000008735 [Q13387-1]
GeneIDⁱ	23542
KEGGⁱ	hsa:23542
UCSC genome browser More...UCSCⁱ	uc032qrw.2 human [Q13387-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q13387	Mitogen-activated protein kinase 8 interacting protein 2		GORGO		847	UniRef90_Q13387
C-Jun-amino-terminal kinase-interacting protein 2 isoform 1		CALJA		830
Uncharacterized protein		Cebus capucinus imitator		828
Uncharacterized protein		AOTNA		825
Mitogen-activated protein kinase 8 interacting protein 2		PANTR		824
+33

Protein	Similar proteins		Species	Score	Length	Source
Q13387	C-Jun-amino-terminal kinase-interacting protein 2		RAT		835	UniRef50_Q13387
C-Jun-amino-terminal kinase-interacting protein 2		MOUSE		830
Mitogen-activated protein kinase 8 interacting protein 2		GORGO		847
C-Jun-amino-terminal kinase-interacting protein 2 isoform 1		CALJA		830
Uncharacterized protein		Cebus capucinus imitator		828
+59
Q13387-3	cDNA FLJ61227, highly similar to C-jun-amino-terminal kinase-interacting protein 2		HUMAN		547	UniRef50_Q13387-3
UPI0003C17698		PANHO		543
UPI000703CB63		CAMFR		528
UPI0005F3CD0C		COLAP		538
UPI000812DCEE		MANJA		534
Q13387-4	C-Jun-amino-terminal kinase-interacting protein 2 (Fragment)		CORBR		233	UniRef50_Q13387-4
Mitogen-activated protein kinase 8 interacting protein 1 (Fragment)		Nothobranchius kadleci		424
C-Jun-amino-terminal kinase-interacting protein 2 (Fragment)		MYODS		434
C-jun-amino-terminal kinase-interacting protein 2		HETGA		407
MAPK8IP1		CEREH		412
+9

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF136382 mRNA Translation: AAF00980.1 AF218778 mRNA Translation: AAF32323.1 U62317 Genomic DNA Translation: AAB03340.1 BC009940 mRNA Translation: AAH09940.2 AL021708 mRNA Translation: CAA16714.1 Different initiation. U79261 mRNA Translation: AAB50207.1
CCDSⁱ	CCDS74886.1 [Q13387-1]
RefSeqⁱ	NP_036456.1, NM_012324.4 [Q13387-1]
UniGeneⁱ	Hs.558180 Hs.656617

3D structure databases

ProteinModelPortalⁱ	Q13387
SMRⁱ	Q13387
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	117086, 95 interactors
IntActⁱ	Q13387, 72 interactors
MINTⁱ	Q13387
STRINGⁱ	9606.ENSP00000330572

Protein family/group databases

MoonDBⁱ	Q13387 Predicted

MoonDBⁱ

Q13387 Predicted

PTM databases

iPTMnetⁱ	Q13387
PhosphoSitePlusⁱ	Q13387

Polymorphism and mutation databases

BioMutaⁱ	MAPK8IP2
DMDMⁱ	17433017

Proteomic databases

PaxDbⁱ	Q13387
PeptideAtlasⁱ	Q13387
PRIDEⁱ	Q13387
ProteomicsDBⁱ	59356 59357 [Q13387-2] 59358 [Q13387-3] 59359 [Q13387-4]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	23542
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000329492; ENSP00000330572; ENSG00000008735 [Q13387-1]
GeneIDⁱ	23542
KEGGⁱ	hsa:23542
UCSCⁱ	uc032qrw.2 human [Q13387-1]

Organism-specific databases

CTDⁱ	23542
DisGeNETⁱ	23542
EuPathDBⁱ	HostDB:ENSG00000008735.13
GeneCardsⁱ	MAPK8IP2
HGNCⁱ	HGNC:6883 MAPK8IP2
HPAⁱ	HPA034780
MIMⁱ	607755 gene
neXtProtⁱ	NX_Q13387
OpenTargetsⁱ	ENSG00000008735
PharmGKBⁱ	PA30627
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3775 Eukaryota ENOG410ZFRJ LUCA
GeneTreeⁱ	ENSGT00390000003908
HOGENOMⁱ	HOG000231470
HOVERGENⁱ	HBG018568
InParanoidⁱ	Q13387
KOⁱ	K04435
OMAⁱ	HKHRPTT
OrthoDBⁱ	EOG091G0T9G
PhylomeDBⁱ	Q13387

Enzyme and pathway databases

SignaLinkⁱ	Q13387
SIGNORⁱ	Q13387

Miscellaneous databases

ChiTaRSⁱ	MAPK8IP2 human
GeneWikiⁱ	MAPK8IP2
GenomeRNAiⁱ	23542
Protein Ontology More...PROⁱ	PR:Q13387
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000008735 Expressed in 182 organ(s), highest expression level in anterior cingulate cortex
CleanExⁱ	HS_MAPK8IP2
Genevisibleⁱ	Q13387 HS

Family and domain databases

CDDⁱ	cd11942 SH3_JIP2, 1 hit
Gene3Dⁱ	2.30.29.30, 1 hit
InterProⁱ	View protein in InterPro IPR035637 JIP2_SH3 IPR011993 PH-like_dom_sf IPR006020 PTB/PI_dom IPR001452 SH3_domain
Pfamⁱ	View protein in Pfam PF00640 PID, 1 hit PF14604 SH3_9, 1 hit
SMARTⁱ	View protein in SMART SM00462 PTB, 1 hit SM00326 SH3, 1 hit
PROSITEⁱ	View protein in PROSITE PS01179 PID, 1 hit PS50002 SH3, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	JIP2_HUMAN
Accessionⁱ	Q13387Primary (citable) accession number: Q13387 Secondary accession number(s): Q96G62 , Q99771, Q9NZ59, Q9UKQ4
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	December 5, 2001
	Last sequence update:	December 5, 2001
	Last modified:	September 12, 2018
	This is version 163 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 22
Human chromosome 22: entries, gene names and cross-references to MIM

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UniProtKB - Q13387 (JIP2_HUMAN)

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C-Jun-amino-terminal kinase-interacting protein 2

MAPK8IP2

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ