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Protein

Phosducin-like protein

Gene

PDCL

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts as a positive regulator of hedgehog signaling and regulates ciliary function.By similarity
Isoform 1: Functions as a co-chaperone for CCT in the assembly of heterotrimeric G protein complexes, facilitates the assembly of both Gbeta-Ggamma and RGS-Gbeta5 heterodimers.
Isoform 2: Acts as a negative regulator of heterotrimeric G proteins assembly by trapping the preloaded G beta subunits inside the CCT chaperonin.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChaperone
Biological processCilium biogenesis/degradation, Sensory transduction, Vision

Enzyme and pathway databases

ReactomeiR-HSA-6814122 Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
SIGNORiQ13371

Names & Taxonomyi

Protein namesi
Recommended name:
Phosducin-like protein
Short name:
PHLP
Gene namesi
Name:PDCL
Synonyms:PHLOP1, PhLP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000136940.13
HGNCiHGNC:8770 PDCL
MIMi604421 gene
neXtProtiNX_Q13371

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000136940
PharmGKBiPA33119

Polymorphism and mutation databases

BioMutaiPDCL

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001637552 – 301Phosducin-like proteinAdd BLAST300

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylthreonine1 Publication1
Modified residuei20PhosphoserineBy similarity1
Modified residuei25PhosphoserineBy similarity1
Modified residuei226PhosphoserineCombined sources1
Modified residuei293PhosphoserineCombined sources1
Modified residuei296PhosphoserineCombined sources1 Publication1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ13371
PaxDbiQ13371
PeptideAtlasiQ13371
PRIDEiQ13371
ProteomicsDBi59355

PTM databases

iPTMnetiQ13371
PhosphoSitePlusiQ13371

Expressioni

Gene expression databases

BgeeiENSG00000136940 Expressed in 226 organ(s), highest expression level in buccal mucosa cell
CleanExiHS_PDCL
ExpressionAtlasiQ13371 baseline and differential
GenevisibleiQ13371 HS

Organism-specific databases

HPAiCAB026473
HPA021571
HPA021647

Interactioni

Subunit structurei

Forms a complex with the beta and gamma subunits of the GTP-binding protein, transducin. Interacts with the CCT chaperonin complex.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
PSMC5P621956EBI-5772890,EBI-357745

Protein-protein interaction databases

BioGridi111116, 66 interactors
CORUMiQ13371
IntActiQ13371, 22 interactors
MINTiQ13371
STRINGi9606.ENSP00000259467

Structurei

3D structure databases

ProteinModelPortaliQ13371
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the phosducin family.Curated

Phylogenomic databases

eggNOGiKOG3171 Eukaryota
ENOG4110DRD LUCA
GeneTreeiENSGT00930000150898
HOGENOMiHOG000232010
HOVERGENiHBG003456
InParanoidiQ13371
OMAiPSIKFAK
OrthoDBiEOG091G0ISM
PhylomeDBiQ13371
TreeFamiTF315179

Family and domain databases

CDDicd02987 Phd_like_Phd, 1 hit
Gene3Di1.10.168.10, 1 hit
InterProiView protein in InterPro
IPR001200 Phosducin
IPR023196 Phosducin_N_dom_sf
IPR024253 Phosducin_thioredoxin-like_dom
IPR036249 Thioredoxin-like_sf
PfamiView protein in Pfam
PF02114 Phosducin, 1 hit
PRINTSiPR00677 PHOSDUCIN
SUPFAMiSSF52833 SSF52833, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q13371-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTTLDDKLLG EKLQYYYSSS EDEDSDHEDK DRGRCAPASS SVPAEAELAG
60 70 80 90 100
EGISVNTGPK GVINDWRRFK QLETEQREEQ CREMERLIKK LSMTCRSHLD
110 120 130 140 150
EEEEQQKQKD LQEKISGKMT LKEFAIMNED QDDEEFLQQY RKQRMEEMRQ
160 170 180 190 200
QLHKGPQFKQ VFEISSGEGF LDMIDKEQKS IVIMVHIYED GIPGTEAMNG
210 220 230 240 250
CMICLAAEYP AVKFCKVKSS VIGASSQFTR NALPALLIYK GGELIGNFVR
260 270 280 290 300
VTDQLGDDFF AVDLEAFLQE FGLLPEKEVL VLTSVRNSAT CHSEDSDLEI

D
Length:301
Mass (Da):34,282
Last modified:January 17, 2003 - v3
Checksum:i717675FF869760D5
GO
Isoform 2 (identifier: Q13371-2) [UniParc]FASTAAdd to basket
Also known as: PhLPs

The sequence of this isoform differs from the canonical sequence as follows:
     1-83: Missing.

Note: Expressed ubiquitously, highest levels are found in neural tissues amounting to 10% of total PDCL mRNA.
Show »
Length:218
Mass (Da):24,902
Checksum:i5B7D4109656A481B
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0Y3M0H0Y3M0_HUMAN
Phosducin-like protein
PDCL
109Annotation score:
H0Y5D3H0Y5D3_HUMAN
Phosducin-like protein
PDCL
91Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti151Q → E in AAD01930 (Ref. 1) Curated1
Sequence conflicti218K → E in CAB56011 (PubMed:11230166).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_050525218K → N. Corresponds to variant dbSNP:rs4466466Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0535711 – 83Missing in isoform 2. CuratedAdd BLAST83

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF031463 mRNA Translation: AAD01930.1
AL117602 mRNA Translation: CAB56011.1
AK313429 mRNA Translation: BAG36221.1
AL359512 Genomic DNA No translation available.
CH471090 Genomic DNA Translation: EAW87546.1
BC017227 mRNA Translation: AAH17227.1
AF083324 Genomic DNA Translation: AAC78848.1
AF083325 Genomic DNA Translation: AAC78849.1
U38236 Genomic DNA Translation: AAA79724.1
CCDSiCCDS6845.1 [Q13371-1]
PIRiT17321
RefSeqiNP_005379.3, NM_005388.4 [Q13371-1]
UniGeneiHs.271749
Hs.620774

Genome annotation databases

EnsembliENST00000259467; ENSP00000259467; ENSG00000136940 [Q13371-1]
GeneIDi5082
KEGGihsa:5082
UCSCiuc004bmz.3 human [Q13371-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF031463 mRNA Translation: AAD01930.1
AL117602 mRNA Translation: CAB56011.1
AK313429 mRNA Translation: BAG36221.1
AL359512 Genomic DNA No translation available.
CH471090 Genomic DNA Translation: EAW87546.1
BC017227 mRNA Translation: AAH17227.1
AF083324 Genomic DNA Translation: AAC78848.1
AF083325 Genomic DNA Translation: AAC78849.1
U38236 Genomic DNA Translation: AAA79724.1
CCDSiCCDS6845.1 [Q13371-1]
PIRiT17321
RefSeqiNP_005379.3, NM_005388.4 [Q13371-1]
UniGeneiHs.271749
Hs.620774

3D structure databases

ProteinModelPortaliQ13371
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111116, 66 interactors
CORUMiQ13371
IntActiQ13371, 22 interactors
MINTiQ13371
STRINGi9606.ENSP00000259467

PTM databases

iPTMnetiQ13371
PhosphoSitePlusiQ13371

Polymorphism and mutation databases

BioMutaiPDCL

Proteomic databases

EPDiQ13371
PaxDbiQ13371
PeptideAtlasiQ13371
PRIDEiQ13371
ProteomicsDBi59355

Protocols and materials databases

DNASUi5082
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000259467; ENSP00000259467; ENSG00000136940 [Q13371-1]
GeneIDi5082
KEGGihsa:5082
UCSCiuc004bmz.3 human [Q13371-1]

Organism-specific databases

CTDi5082
EuPathDBiHostDB:ENSG00000136940.13
GeneCardsiPDCL
HGNCiHGNC:8770 PDCL
HPAiCAB026473
HPA021571
HPA021647
MIMi604421 gene
neXtProtiNX_Q13371
OpenTargetsiENSG00000136940
PharmGKBiPA33119
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3171 Eukaryota
ENOG4110DRD LUCA
GeneTreeiENSGT00930000150898
HOGENOMiHOG000232010
HOVERGENiHBG003456
InParanoidiQ13371
OMAiPSIKFAK
OrthoDBiEOG091G0ISM
PhylomeDBiQ13371
TreeFamiTF315179

Enzyme and pathway databases

ReactomeiR-HSA-6814122 Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
SIGNORiQ13371

Miscellaneous databases

ChiTaRSiPDCL human
GeneWikiiPhosducin-like
GenomeRNAii5082
PROiPR:Q13371
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000136940 Expressed in 226 organ(s), highest expression level in buccal mucosa cell
CleanExiHS_PDCL
ExpressionAtlasiQ13371 baseline and differential
GenevisibleiQ13371 HS

Family and domain databases

CDDicd02987 Phd_like_Phd, 1 hit
Gene3Di1.10.168.10, 1 hit
InterProiView protein in InterPro
IPR001200 Phosducin
IPR023196 Phosducin_N_dom_sf
IPR024253 Phosducin_thioredoxin-like_dom
IPR036249 Thioredoxin-like_sf
PfamiView protein in Pfam
PF02114 Phosducin, 1 hit
PRINTSiPR00677 PHOSDUCIN
SUPFAMiSSF52833 SSF52833, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPHLP_HUMAN
AccessioniPrimary (citable) accession number: Q13371
Secondary accession number(s): Q4VXB6
, Q96AF1, Q9UEW7, Q9UFL0, Q9UNX1, Q9UNX2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: January 17, 2003
Last modified: November 7, 2018
This is version 161 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
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