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UniProtKB - Q13370 (PDE3B_HUMAN)

Entry version 187 (12 Aug 2020)
Sequence version 2 (03 Apr 2007)
Previous versions | rss
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Protein

cGMP-inhibited 3',5'-cyclic phosphodiesterase B

Gene

PDE3B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. May play a role in fat metabolism. Regulates cAMP binding of RAPGEF3. Through simultaneous binding to RAPGEF3 and PIK3R6 assembles a signaling complex in which the PI3K gamma complex is activated by RAPGEF3 and which is involved in angiogenesis.2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

a divalent metal cation1 PublicationNote: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Inhibited by cGMP.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei737Proton donorBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi741Divalent metal cation 11
Metal bindingi821Divalent metal cation 11
Metal bindingi822Divalent metal cation 11
Metal bindingi822Divalent metal cation 21
Metal bindingi937Divalent metal cation 11

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase
Biological processAngiogenesis
LigandcAMP, cGMP, Metal-binding

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...BRENDAi		3.1.4.17, 2681

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q13370

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-165160, PDE3B signalling
R-HSA-418555, G alpha (s) signalling events

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q13370

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q13370

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
cGMP-inhibited 3',5'-cyclic phosphodiesterase B (EC:3.1.4.17)
Alternative name(s):
CGIPDE1
Short name:
CGIP1
Cyclic GMP-inhibited phosphodiesterase B
Short name:
CGI-PDE B
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PDE3B
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000152270.8

Human Gene Nomenclature Database

More...HGNCi		HGNC:8779, PDE3B

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		602047, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q13370

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei88 – 108HelicalSequence analysisAdd BLAST21
Transmembranei117 – 137HelicalSequence analysisAdd BLAST21
Transmembranei152 – 172HelicalSequence analysisAdd BLAST21
Transmembranei192 – 212HelicalSequence analysisAdd BLAST21
Transmembranei220 – 240HelicalSequence analysisAdd BLAST21
Transmembranei247 – 267HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi2R → A: Abolishes interaction with RAPGEF3. 1 Publication1
Mutagenesisi3R → A: Abolishes interaction with RAPGEF3. 1 Publication1
Mutagenesisi6R → A: Abolishes interaction with RAPGEF3. 1 Publication1
Mutagenesisi8A → D: Impairs interaction with RAPGEF3. 1 Publication1
Mutagenesisi9K → A: Abolishes interaction with RAPGEF3. 1 Publication1
Mutagenesisi10A → D: Impairss interaction with RAPGEF3. 1 Publication1
Mutagenesisi12R → A: Abolishes interaction with RAPGEF3. 1 Publication1
Mutagenesisi439R → A: Impairss interaction with PIK3R6. 1 Publication1
Mutagenesisi440R → A: Impairss interaction with PIK3R6. 1 Publication1
Mutagenesisi445S → A: Impairss interaction with PIK3R6. 1 Publication1
Mutagenesisi449P → A: Impairss interaction with PIK3R6. 1 Publication1

Organism-specific databases

DisGeNET

More...DisGeNETi		5140

Open Targets

More...OpenTargetsi		ENSG00000152270

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA33127

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q13370, Tclin

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL290

Drug and drug target database

More...DrugBanki		DB07954, 3-isobutyl-1-methyl-7H-xanthine
DB01640, 6-(4-{[2-(3-iodobenzyl)-3-oxocyclohex-1-en-1-yl]amino}phenyl)-5-methyl-4,5-dihydropyridazin-3(2H)-one
DB01427, Amrinone
DB00201, Caffeine
DB01970, Hg9a-9, Nonanoyl-N-Hydroxyethylglucamide
DB09283, Trapidil

DrugCentral

More...DrugCentrali		Q13370

IUPHAR/BPS Guide to PHARMACOLOGY

More...GuidetoPHARMACOLOGYi		1299

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		PDE3B

Domain mapping of disease mutations (DMDM)

More...DMDMi		143811435

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001988021 – 1112cGMP-inhibited 3',5'-cyclic phosphodiesterase BAdd BLAST1112

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei13PhosphoserineBy similarity1
Modified residuei295Phosphoserine; by PKB/AKT1 or PKB/AKT2By similarity1
Modified residuei296PhosphoserineBy similarity1
Modified residuei442PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q13370

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q13370

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q13370

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q13370

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q13370

PeptideAtlas

More...PeptideAtlasi		Q13370

PRoteomics IDEntifications database

More...PRIDEi		Q13370

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		59354 [Q13370-1]
7244

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q13370

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q13370

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Abundant in adipose tissues.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000152270, Expressed in adipose tissue and 175 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q13370, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000152270, Tissue enhanced (adipose)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with PIK3CG (By similarity).

Interacts with RAPGEF3 and PIK3R6.

By similarity2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		111166, 52 interactors

Protein interaction database and analysis system

More...IntActi		Q13370, 22 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000282096

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		Q13370

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q13370, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11112
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q13370

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		Q13370

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini651 – 1079PDEasePROSITE-ProRule annotationAdd BLAST429

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 25Interaction with RAPGEF31 PublicationAdd BLAST25
Regioni436 – 460Interaction with PIK3R61 PublicationAdd BLAST25

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1077 – 1080Poly-Glu4

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the cyclic nucleotide phosphodiesterase family. PDE3 subfamily.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502QSV8, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000159336

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_008844_1_0_1

KEGG Orthology (KO)

More...KOi		K13296

Identification of Orthologs from Complete Genome Data

More...OMAi		GIEWSSE

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q13370

TreeFam database of animal gene trees

More...TreeFami		TF329631

Family and domain databases

Conserved Domains Database

More...CDDi		cd00077, HDc, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.1300.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR003607, HD/PDEase_dom
IPR002073, PDEase_catalytic_dom
IPR036971, PDEase_catalytic_dom_sf
IPR023174, PDEase_CS

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00233, PDEase_I, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00471, HDc, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00126, PDEASE_I_1, 1 hit
PS51845, PDEASE_I_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q13370-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRRDERDAKA MRSLQPPDGA GSPPESLRNG YVKSCVSPLR QDPPRGFFFH 
        60         70         80         90        100
LCRFCNVELR PPPASPQQPR RCSPFCRARL SLGALAAFVL ALLLGAEPES 
       110        120        130        140        150
WAAGAAWLRT LLSVCSHSLS PLFSIACAFF FLTCFLTRTK RGPGPGRSCG 
       160        170        180        190        200
SWWLLALPAC CYLGDFLVWQ WWSWPWGDGD AGSAAPHTPP EAAAGRLLLV 
       210        220        230        240        250
LSCVGLLLTL AHPLRLRHCV LVLLLASFVW WVSFTSLGSL PSALRPLLSG 
       260        270        280        290        300
LVGGAGCLLA LGLDHFFQIR EAPLHPRLSS AAEEKVPVIR PRRRSSCVSL 
       310        320        330        340        350
GETAASYYGS CKIFRRPSLP CISREQMILW DWDLKQWYKP HYQNSGGGNG 
       360        370        380        390        400
VDLSVLNEAR NMVSDLLTDP SLPPQVISSL RSISSLMGAF SGSCRPKINP 
       410        420        430        440        450
LTPFPGFYPC SEIEDPAEKG DRKLNKGLNR NSLPTPQLRR SSGTSGLLPV 
       460        470        480        490        500
EQSSRWDRNN GKRPHQEFGI SSQGCYLNGP FNSNLLTIPK QRSSSVSLTH 
       510        520        530        540        550
HVGLRRAGVL SSLSPVNSSN HGPVSTGSLT NRSPIEFPDT ADFLNKPSVI 
       560        570        580        590        600
LQRSLGNAPN TPDFYQQLRN SDSNLCNSCG HQMLKYVSTS ESDGTDCCSG 
       610        620        630        640        650
KSGEEENIFS KESFKLMETQ QEEETEKKDS RKLFQEGDKW LTEEAQSEQQ 
       660        670        680        690        700
TNIEQEVSLD LILVEEYDSL IEKMSNWNFP IFELVEKMGE KSGRILSQVM 
       710        720        730        740        750
YTLFQDTGLL EIFKIPTQQF MNYFRALENG YRDIPYHNRI HATDVLHAVW 
       760        770        780        790        800
YLTTRPVPGL QQIHNGCGTG NETDSDGRIN HGRIAYISSK SCSNPDESYG 
       810        820        830        840        850
CLSSNIPALE LMALYVAAAM HDYDHPGRTN AFLVATNAPQ AVLYNDRSVL 
       860        870        880        890        900
ENHHAASAWN LYLSRPEYNF LLHLDHVEFK RFRFLVIEAI LATDLKKHFD 
       910        920        930        940        950
FLAEFNAKAN DVNSNGIEWS NENDRLLVCQ VCIKLADING PAKVRDLHLK 
       960        970        980        990       1000
WTEGIVNEFY EQGDEEANLG LPISPFMDRS SPQLAKLQES FITHIVGPLC 
      1010       1020       1030       1040       1050
NSYDAAGLLP GQWLEAEEDN DTESGDDEDG EELDTEDEEM ENNLNPKPPR 
      1060       1070       1080       1090       1100
RKSRRRIFCQ LMHHLTENHK IWKEIVEEEE KCKADGNKLQ VENSSLPQAD 
      1110 
EIQVIEEADE EE
Length:1,112
Mass (Da):124,333
Last modified:April 3, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i55451C3DA142EF6A
GO
Isoform 2 (identifier: Q13370-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     376-426: Missing.

Show »
Length:1,061
Mass (Da):118,809
Checksum:i755DBD55004867DC
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti84A → D in AAC50724 (PubMed:8884271).Curated1
Sequence conflicti84A → D in BAA09306 (PubMed:8706823).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_03146287A → V1 PublicationCorresponds to variant dbSNP:rs1056584Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_054138376 – 426Missing in isoform 2. 1 PublicationAdd BLAST51

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
U38178 Genomic DNA Translation: AAC50724.1
D50640 Genomic DNA Translation: BAA09306.1
X95520 mRNA Translation: CAA64774.1
AY459346 mRNA Translation: AAR24292.1
AC018795 Genomic DNA No translation available.
AC087207 Genomic DNA No translation available.
AC090835 Genomic DNA No translation available.
CH471064 Genomic DNA Translation: EAW68474.1
BC136565 mRNA Translation: AAI36566.1
BC136566 mRNA Translation: AAI36567.1
BC144248 mRNA Translation: AAI44249.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS7817.1 [Q13370-1]

Protein sequence database of the Protein Information Resource

More...PIRi		S70522

NCBI Reference Sequences

More...RefSeqi		NP_000913.2, NM_000922.3 [Q13370-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000282096; ENSP00000282096; ENSG00000152270 [Q13370-1]
ENST00000455098; ENSP00000388644; ENSG00000152270 [Q13370-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		5140

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:5140

UCSC genome browser

More...UCSCi		uc001mln.4, human [Q13370-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U38178 Genomic DNA Translation: AAC50724.1
D50640 Genomic DNA Translation: BAA09306.1
X95520 mRNA Translation: CAA64774.1
AY459346 mRNA Translation: AAR24292.1
AC018795 Genomic DNA No translation available.
AC087207 Genomic DNA No translation available.
AC090835 Genomic DNA No translation available.
CH471064 Genomic DNA Translation: EAW68474.1
BC136565 mRNA Translation: AAI36566.1
BC136566 mRNA Translation: AAI36567.1
BC144248 mRNA Translation: AAI44249.1
CCDSiCCDS7817.1 [Q13370-1]
PIRiS70522
RefSeqiNP_000913.2, NM_000922.3 [Q13370-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1SO2X-ray2.40A/B/C/D654-1073[»]
1SOJX-ray2.90A/B/C/D/E/F/G/H/I/J/K/L654-1073[»]
SMRiQ13370
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi111166, 52 interactors
IntActiQ13370, 22 interactors
STRINGi9606.ENSP00000282096

Chemistry databases

BindingDBiQ13370
ChEMBLiCHEMBL290
DrugBankiDB07954, 3-isobutyl-1-methyl-7H-xanthine
DB01640, 6-(4-{[2-(3-iodobenzyl)-3-oxocyclohex-1-en-1-yl]amino}phenyl)-5-methyl-4,5-dihydropyridazin-3(2H)-one
DB01427, Amrinone
DB00201, Caffeine
DB01970, Hg9a-9, Nonanoyl-N-Hydroxyethylglucamide
DB09283, Trapidil
DrugCentraliQ13370
GuidetoPHARMACOLOGYi1299

PTM databases

iPTMnetiQ13370
PhosphoSitePlusiQ13370

Polymorphism and mutation databases

BioMutaiPDE3B
DMDMi143811435

Proteomic databases

EPDiQ13370
jPOSTiQ13370
MassIVEiQ13370
MaxQBiQ13370
PaxDbiQ13370
PeptideAtlasiQ13370
PRIDEiQ13370
ProteomicsDBi59354 [Q13370-1]
7244

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		4012, 191 antibodies

Genome annotation databases

EnsembliENST00000282096; ENSP00000282096; ENSG00000152270 [Q13370-1]
ENST00000455098; ENSP00000388644; ENSG00000152270 [Q13370-2]
GeneIDi5140
KEGGihsa:5140
UCSCiuc001mln.4, human [Q13370-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		5140
DisGeNETi5140
EuPathDBiHostDB:ENSG00000152270.8

GeneCards: human genes, protein and diseases

More...GeneCardsi		PDE3B
HGNCiHGNC:8779, PDE3B
HPAiENSG00000152270, Tissue enhanced (adipose)
MIMi602047, gene
neXtProtiNX_Q13370
OpenTargetsiENSG00000152270
PharmGKBiPA33127

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502QSV8, Eukaryota
GeneTreeiENSGT00940000159336
HOGENOMiCLU_008844_1_0_1
KOiK13296
OMAiGIEWSSE
PhylomeDBiQ13370
TreeFamiTF329631

Enzyme and pathway databases

BRENDAi3.1.4.17, 2681
PathwayCommonsiQ13370
ReactomeiR-HSA-165160, PDE3B signalling
R-HSA-418555, G alpha (s) signalling events
SignaLinkiQ13370
SIGNORiQ13370

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		5140, 4 hits in 870 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		PDE3B, human
EvolutionaryTraceiQ13370

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		5140
PharosiQ13370, Tclin

Protein Ontology

More...PROi		PR:Q13370
RNActiQ13370, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000152270, Expressed in adipose tissue and 175 other tissues
GenevisibleiQ13370, HS

Family and domain databases

CDDicd00077, HDc, 1 hit
Gene3Di1.10.1300.10, 1 hit
InterProiView protein in InterPro
IPR003607, HD/PDEase_dom
IPR002073, PDEase_catalytic_dom
IPR036971, PDEase_catalytic_dom_sf
IPR023174, PDEase_CS
PfamiView protein in Pfam
PF00233, PDEase_I, 1 hit
SMARTiView protein in SMART
SM00471, HDc, 1 hit
PROSITEiView protein in PROSITE
PS00126, PDEASE_I_1, 1 hit
PS51845, PDEASE_I_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPDE3B_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q13370
Secondary accession number(s): B7ZM37
, O00639, Q14408, Q6SEI4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: April 3, 2007
Last modified: August 12, 2020
This is version 187 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families
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