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Entry version 158 (16 Oct 2019)
Sequence version 2 (26 Sep 2001)
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Protein

AP-3 complex subunit beta-2

Gene

AP3B2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Subunit of non-clathrin- and clathrin-associated adaptor protein complex 3 (AP-3) that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. AP-3 appears to be involved in the sorting of a subset of transmembrane proteins targeted to lysosomes and lysosome-related organelles. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processProtein transport, Transport

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
AP-3 complex subunit beta-2
Alternative name(s):
Adaptor protein complex AP-3 subunit beta-2
Adaptor-related protein complex 3 subunit beta-2
Beta-3B-adaptin
Clathrin assembly protein complex 3 beta-2 large chain
Neuron-specific vesicle coat protein beta-NAP
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:AP3B2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 15

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:567 AP3B2

Online Mendelian Inheritance in Man (OMIM)

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MIMi
602166 gene

neXtProt; the human protein knowledge platform

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neXtProti
NX_Q13367

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasmic vesicle, Golgi apparatus, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Epileptic encephalopathy, early infantile, 48 (EIEE48)2 Publications
The disease may be caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of epileptic encephalopathy, a heterogeneous group of severe childhood onset epilepsies characterized by refractory seizures, neurodevelopmental impairment, and poor prognosis. Development is normal prior to seizure onset, after which cognitive and motor delays become apparent. EIEE48 is an autosomal recessive form characterized by onset of seizures in the first year of life. Affected individuals manifest global developmental delay, intellectual disability, absent speech, and poor, if any, motor development.
Related information in OMIM

Keywords - Diseasei

Epilepsy

Organism-specific databases

DisGeNET

More...
DisGeNETi
8120

MalaCards human disease database

More...
MalaCardsi
AP3B2
MIMi617276 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000103723

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
442835 Undetermined early-onset epileptic encephalopathy

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA24858

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q13367

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
AP3B2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
18202497

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001937481 – 1082AP-3 complex subunit beta-2Add BLAST1082

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei272PhosphoserineCombined sources1
Modified residuei282PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q13367

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q13367

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q13367

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q13367

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q13367

PeptideAtlas

More...
PeptideAtlasi
Q13367

PRoteomics IDEntifications database

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PRIDEi
Q13367

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
59351 [Q13367-1]
59352 [Q13367-2]
7189
7190

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q13367

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q13367

SwissPalm database of S-palmitoylation events

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SwissPalmi
Q13367

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Isoform 1 expression is specific to nervous system. Expressed in nerve terminal and cell body, and is associated with nerve-terminal vesicles. Expression seen in Purkinje cells, cortical neurons, neuroectodermal tumors and graded in cerebral cortex (deeper layers exhibit stronger expression) (PubMed:1851215). Isoform 2 is expressed at high levels in brain and testis (PubMed:17453999).2 Publications

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed from early in development through adulthood.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000103723 Expressed in 139 organ(s), highest expression level in right hemisphere of cerebellum

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q13367 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q13367 HS

Organism-specific databases

Human Protein Atlas

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HPAi
HPA039467
HPA039818

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

AP-3 associates with the BLOC-1 complex (By similarity). Adaptor protein complex 3 (AP-3) is a heterotetramer composed of two large adaptins (delta-type subunit AP3D1 and beta-type subunit AP3B1 or AP3B2), a medium adaptin (mu-type subunit AP3M1 or AP3M2) and a small adaptin (sigma-type subunit APS1 or AP3S2).

By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
113788, 10 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
Q13367

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

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ELMi
Q13367

Protein interaction database and analysis system

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IntActi
Q13367, 7 interactors

Molecular INTeraction database

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MINTi
Q13367

STRING: functional protein association networks

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STRINGi
9606.ENSP00000440984

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi646 – 798Glu/Ser-richAdd BLAST153

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1060 Eukaryota
COG5096 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000156817

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q13367

KEGG Orthology (KO)

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KOi
K12397

Identification of Orthologs from Complete Genome Data

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OMAi
CYRLDPN

Database of Orthologous Groups

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OrthoDBi
323029at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q13367

TreeFam database of animal gene trees

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TreeFami
TF314605

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR026740 AP3_beta
IPR029390 AP3B_C
IPR026739 AP_beta
IPR016024 ARM-type_fold
IPR002553 Clathrin/coatomer_adapt-like_N
IPR013041 Clathrin_app_Ig-like_sf

The PANTHER Classification System

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PANTHERi
PTHR11134 PTHR11134, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF01602 Adaptin_N, 1 hit
PF14796 AP3B1_C, 1 hit

PIRSF; a whole-protein classification database

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PIRSFi
PIRSF037096 AP3_complex_beta, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM01355 AP3B1_C, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371 SSF48371, 1 hit
SSF49348 SSF49348, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q13367-1) [UniParc]FASTAAdd to basket
Also known as: AP3B2_v1

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSAAPAYSED KGGSAGPGEP EYGHDPASGG IFSSDYKRHD DLKEMLDTNK
60 70 80 90 100
DSLKLEAMKR IVAMIARGKN ASDLFPAVVK NVACKNIEVK KLVYVYLVRY
110 120 130 140 150
AEEQQDLALL SISTFQRGLK DPNQLIRASA LRVLSSIRVP IIVPIMMLAI
160 170 180 190 200
KEAASDMSPY VRKTAAHAIP KLYSLDSDQK DQLIEVIEKL LADKTTLVAG
210 220 230 240 250
SVVMAFEEVC PERIDLIHKN YRKLCNLLID VEEWGQVVII SMLTRYARTQ
260 270 280 290 300
FLSPTQNESL LEENAEKAFY GSEEDEAKGA GSEETAAAAA PSRKPYVMDP
310 320 330 340 350
DHRLLLRNTK PLLQSRSAAV VMAVAQLYFH LAPKAEVGVI AKALVRLLRS
360 370 380 390 400
HSEVQYVVLQ NVATMSIKRR GMFEPYLKSF YIRSTDPTQI KILKLEVLTN
410 420 430 440 450
LANETNIPTV LREFQTYIRS MDKDFVAATI QAIGRCATNI GRVRDTCLNG
460 470 480 490 500
LVQLLSNRDE LVVAESVVVI KKLLQMQPAQ HGEIIKHLAK LTDNIQVPMA
510 520 530 540 550
RASILWLIGE YCEHVPRIAP DVLRKMAKSF TAEEDIVKLQ VINLAAKLYL
560 570 580 590 600
TNSKQTKLLT QYVLSLAKYD QNYDIRDRAR FTRQLIVPSE QGGALSRHAK
610 620 630 640 650
KLFLAPKPAP VLESSFKDRD HFQLGSLSHL LNAKATGYQE LPDWPEEAPD
660 670 680 690 700
PSVRNVEVPE WTKCSNREKR KEKEKPFYSD SEGESGPTES ADSDPESESE
710 720 730 740 750
SDSKSSSESG SGESSSESDN EDQDEDEEKG RGSESEQSEE DGKRKTKKKV
760 770 780 790 800
PERKGEASSS DEGSDSSSSS SESEMTSESE EEQLEPASWS RKTPPSSKSA
810 820 830 840 850
PATKEISLLD LEDFTPPSVQ PVSPPAIVST SLAADLEGLT LTDSTLVPSL
860 870 880 890 900
LSPVSGVGRQ ELLHRVAGEG LAVDYTFSRQ PFSGDPHMVS VHIHFSNSSD
910 920 930 940 950
TPIKGLHVGT PKLPAGISIQ EFPEIESLAP GESATAVMGI NFCDSTQAAN
960 970 980 990 1000
FQLCTQTRQF YVSIQPPVGE LMAPVFMSEN EFKKEQGKLM GMNEITEKLM
1010 1020 1030 1040 1050
LPDTCRSDHI VVQKVTATAN LGRVPCGTSD EYRFAGRTLT GGSLVLLTLD
1060 1070 1080
ARPAGAAQLT VNSEKMVIGT MLVKDVIQAL TQ
Length:1,082
Mass (Da):119,059
Last modified:September 26, 2001 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iEE2AC45263F4552E
GO
Isoform 2 (identifier: Q13367-2) [UniParc]FASTAAdd to basket
Also known as: AP3B2_v2

The sequence of this isoform differs from the canonical sequence as follows:
     1-937: Missing.

Show »
Length:145
Mass (Da):15,820
Checksum:i4A06E9AAB3DF84DB
GO
Isoform 3 (identifier: Q13367-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     89-120: Missing.

Note: No experimental confirmation available.
Show »
Length:1,050
Mass (Da):115,305
Checksum:iF6364F9B117BB4EC
GO
Isoform 4 (identifier: Q13367-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     656-656: V → VEEEDLSLIETHVGLLGEYT

Note: No experimental confirmation available.
Show »
Length:1,101
Mass (Da):121,189
Checksum:iE53694990E7D54E7
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2R8Y2A8A0A2R8Y2A8_HUMAN
AP-3 complex subunit beta
AP3B2
1,125Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5GYB0F5GYB0_HUMAN
AP-3 complex subunit beta-2
AP3B2
141Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5GWU4F5GWU4_HUMAN
AP-3 complex subunit beta-2
AP3B2
193Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti332 – 346APKAE…KALVR → GPRRKWRHRQGAGA in AAC50219 (PubMed:7671305).CuratedAdd BLAST15

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0439051 – 937Missing in isoform 2. 1 PublicationAdd BLAST937
Alternative sequenceiVSP_05491889 – 120Missing in isoform 3. 1 PublicationAdd BLAST32
Alternative sequenceiVSP_054919656V → VEEEDLSLIETHVGLLGEYT in isoform 4. Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
U37673 mRNA Translation: AAC50219.1
AF022152 mRNA Translation: AAB71894.1
DQ092369 mRNA Translation: AAZ38147.1
AC105339 Genomic DNA No translation available.
FJ695193 Genomic DNA No translation available.
BC093739 mRNA Translation: AAH93739.1
BC143342 mRNA Translation: AAI43343.1
BC143346 mRNA Translation: AAI43347.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS45331.1 [Q13367-1]
CCDS61736.1 [Q13367-3]
CCDS61737.1 [Q13367-4]

Protein sequence database of the Protein Information Resource

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PIRi
T50650

NCBI Reference Sequences

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RefSeqi
NP_001265440.1, NM_001278511.1 [Q13367-3]
NP_001265441.1, NM_001278512.1 [Q13367-4]
NP_001335370.1, NM_001348441.1 [Q13367-2]
NP_004635.2, NM_004644.4 [Q13367-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000261722; ENSP00000261722; ENSG00000103723 [Q13367-1]
ENST00000535348; ENSP00000438721; ENSG00000103723 [Q13367-3]
ENST00000535359; ENSP00000440984; ENSG00000103723 [Q13367-4]
ENST00000620652; ENSP00000479229; ENSG00000103723 [Q13367-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
8120

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:8120

UCSC genome browser

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UCSCi
uc010uoh.4 human [Q13367-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U37673 mRNA Translation: AAC50219.1
AF022152 mRNA Translation: AAB71894.1
DQ092369 mRNA Translation: AAZ38147.1
AC105339 Genomic DNA No translation available.
FJ695193 Genomic DNA No translation available.
BC093739 mRNA Translation: AAH93739.1
BC143342 mRNA Translation: AAI43343.1
BC143346 mRNA Translation: AAI43347.1
CCDSiCCDS45331.1 [Q13367-1]
CCDS61736.1 [Q13367-3]
CCDS61737.1 [Q13367-4]
PIRiT50650
RefSeqiNP_001265440.1, NM_001278511.1 [Q13367-3]
NP_001265441.1, NM_001278512.1 [Q13367-4]
NP_001335370.1, NM_001348441.1 [Q13367-2]
NP_004635.2, NM_004644.4 [Q13367-1]

3D structure databases

Database of comparative protein structure models

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ModBasei
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SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi113788, 10 interactors
CORUMiQ13367
ELMiQ13367
IntActiQ13367, 7 interactors
MINTiQ13367
STRINGi9606.ENSP00000440984

PTM databases

iPTMnetiQ13367
PhosphoSitePlusiQ13367
SwissPalmiQ13367

Polymorphism and mutation databases

BioMutaiAP3B2
DMDMi18202497

Proteomic databases

EPDiQ13367
jPOSTiQ13367
MassIVEiQ13367
MaxQBiQ13367
PaxDbiQ13367
PeptideAtlasiQ13367
PRIDEiQ13367
ProteomicsDBi59351 [Q13367-1]
59352 [Q13367-2]
7189
7190

Genome annotation databases

EnsembliENST00000261722; ENSP00000261722; ENSG00000103723 [Q13367-1]
ENST00000535348; ENSP00000438721; ENSG00000103723 [Q13367-3]
ENST00000535359; ENSP00000440984; ENSG00000103723 [Q13367-4]
ENST00000620652; ENSP00000479229; ENSG00000103723 [Q13367-1]
GeneIDi8120
KEGGihsa:8120
UCSCiuc010uoh.4 human [Q13367-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
8120
DisGeNETi8120

GeneCards: human genes, protein and diseases

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GeneCardsi
AP3B2
HGNCiHGNC:567 AP3B2
HPAiHPA039467
HPA039818
MalaCardsiAP3B2
MIMi602166 gene
617276 phenotype
neXtProtiNX_Q13367
OpenTargetsiENSG00000103723
Orphaneti442835 Undetermined early-onset epileptic encephalopathy
PharmGKBiPA24858

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG1060 Eukaryota
COG5096 LUCA
GeneTreeiENSGT00940000156817
InParanoidiQ13367
KOiK12397
OMAiCYRLDPN
OrthoDBi323029at2759
PhylomeDBiQ13367
TreeFamiTF314605

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
AP3B2 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
AP3B2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
8120
PharosiQ13367

Protein Ontology

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PROi
PR:Q13367

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000103723 Expressed in 139 organ(s), highest expression level in right hemisphere of cerebellum
ExpressionAtlasiQ13367 baseline and differential
GenevisibleiQ13367 HS

Family and domain databases

InterProiView protein in InterPro
IPR026740 AP3_beta
IPR029390 AP3B_C
IPR026739 AP_beta
IPR016024 ARM-type_fold
IPR002553 Clathrin/coatomer_adapt-like_N
IPR013041 Clathrin_app_Ig-like_sf
PANTHERiPTHR11134 PTHR11134, 1 hit
PfamiView protein in Pfam
PF01602 Adaptin_N, 1 hit
PF14796 AP3B1_C, 1 hit
PIRSFiPIRSF037096 AP3_complex_beta, 1 hit
SMARTiView protein in SMART
SM01355 AP3B1_C, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit
SSF49348 SSF49348, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAP3B2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q13367
Secondary accession number(s): A4Z4T7
, B7ZKR7, B7ZKS0, O14808, Q52LY8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: September 26, 2001
Last modified: October 16, 2019
This is version 158 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
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