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UniProtKB - Q13362 (2A5G_HUMAN)

Entry version 200 (02 Dec 2020)
Sequence version 3 (17 Oct 2006)
Previous versions | rss
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Protein

Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform

Gene

PPP2R5C

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. The PP2A-PPP2R5C holoenzyme may specifically dephosphorylate and activate TP53 and play a role in DNA damage-induced inhibition of cell proliferation. PP2A-PPP2R5C may also regulate the ERK signaling pathway through ERK dephosphorylation.2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q13362

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-141444, Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
R-HSA-195253, Degradation of beta-catenin by the destruction complex
R-HSA-196299, Beta-catenin phosphorylation cascade
R-HSA-2467813, Separation of Sister Chromatids
R-HSA-2500257, Resolution of Sister Chromatid Cohesion
R-HSA-389513, CTLA4 inhibitory signaling
R-HSA-432142, Platelet sensitization by LDL
R-HSA-4641262, Disassembly of the destruction complex and recruitment of AXIN to the membrane
R-HSA-5339716, Misspliced GSK3beta mutants stabilize beta-catenin
R-HSA-5358747, S33 mutants of beta-catenin aren't phosphorylated
R-HSA-5358749, S37 mutants of beta-catenin aren't phosphorylated
R-HSA-5358751, S45 mutants of beta-catenin aren't phosphorylated
R-HSA-5358752, T41 mutants of beta-catenin aren't phosphorylated
R-HSA-5467337, APC truncation mutants have impaired AXIN binding
R-HSA-5467340, AXIN missense mutants destabilize the destruction complex
R-HSA-5467348, Truncations of AMER1 destabilize the destruction complex
R-HSA-5663220, RHO GTPases Activate Formins
R-HSA-5673000, RAF activation
R-HSA-5675221, Negative regulation of MAPK pathway
R-HSA-6804757, Regulation of TP53 Degradation
R-HSA-6811558, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
R-HSA-68877, Mitotic Prometaphase
R-HSA-9648025, EML4 and NUDC in mitotic spindle formation

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q13362

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q13362

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform
Alternative name(s):
PP2A B subunit isoform B'-gamma
PP2A B subunit isoform B56-gamma
PP2A B subunit isoform PR61-gamma
PP2A B subunit isoform R5-gamma
Renal carcinoma antigen NY-REN-29
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PPP2R5C
Synonyms:KIAA0044
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 14

Organism-specific databases

Eukaryotic Pathogen and Host Database Resources

More...EuPathDBi		HostDB:ENSG00000078304.19

Human Gene Nomenclature Database

More...HGNCi		HGNC:9311, PPP2R5C

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		601645, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q13362

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Centromere, Chromosome, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		5527

Open Targets

More...OpenTargetsi		ENSG00000078304

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA33674

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q13362, Tbio

Chemistry databases

Drug and drug target database

More...DrugBanki		DB06905, (2S,3S,4E,6E,8S,9S)-3-amino-9-methoxy-2,6,8-trimethyl-10-phenyldeca-4,6-dienoic acid
DB02506, 2,6,8-Trimethyl-3-Amino-9-Benzyl-9-Methoxynonanoic Acid

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		PPP2R5C

Domain mapping of disease mutations (DMDM)

More...DMDMi		116241235

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000714571 – 524Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoformAdd BLAST524

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Isoform Gamma-3 is phosphorylated on serine residues. Isoform Gamma-1 phosphorylation by ERK2 is IER3-dependent and inhibits ERK dephosphorylation by PP2A-PPP2R5C.2 Publications

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q13362

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q13362

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q13362

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q13362

PeptideAtlas

More...PeptideAtlasi		Q13362

PRoteomics IDEntifications database

More...PRIDEi		Q13362

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		24176
59345
59346 [Q13362-2]
59347 [Q13362-3]
59348 [Q13362-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q13362

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q13362

SwissPalm database of S-palmitoylation events

More...SwissPalmi		Q13362

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highest levels in heart, skeletal muscle and brain. Lower levels in pancreas, kidney, lung and placenta. Very low levels in liver.

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Up-regulated upon DNA damage.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000078304, Expressed in sperm and 244 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q13362, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q13362, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000078304, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

PP2A consists of a common heterodimeric core enzyme, composed of PPP2CA a 36 kDa catalytic subunit (subunit C) and PPP2R1A a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules.

Interacts with PPP2CA AND PPP2R1A; the interaction is direct.

Interacts with SGO1; the interaction is direct. Isoform 1 and isoform 2 interact with TP53 (phosphorylated at Ser-15 by ATM); increased upon DNA damage it drives PP2A-mediated dephosphorylation of TP53 at Thr-55.

Interacts with IER3 and/or ERK kinases; regulates ERK dephosphorylation.

Interacts with CIP2A; this interaction stabilizes CIP2A (PubMed:28174209).

9 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		111519, 45 interactors

Database of interacting proteins

More...DIPi		DIP-39401N

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...ELMi		Q13362

Protein interaction database and analysis system

More...IntActi		Q13362, 29 interactors

Molecular INTeraction database

More...MINTi		Q13362

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000412324

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q13362, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1524
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q13362

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		Q13362

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi416 – 422Nuclear localization signalSequence analysis7

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the phosphatase 2A regulatory subunit B56 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG2085, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT01010000222363

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_012437_3_2_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q13362

Identification of Orthologs from Complete Genome Data

More...OMAi		ECSQNFN

Database of Orthologous Groups

More...OrthoDBi		890437at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q13362

TreeFam database of animal gene trees

More...TreeFami		TF105556

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.25.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR011989, ARM-like
IPR016024, ARM-type_fold
IPR002554, PP2A_B56

The PANTHER Classification System

More...PANTHERi		PTHR10257, PTHR10257, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01603, B56, 1 hit

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF028043, PP2A_B56, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48371, SSF48371, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 5 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 16 potential isoforms that are computationally mapped.Show allAlign All

Isoform Gamma-3 (identifier: Q13362-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLTCNKAGSR MVVDAANSNG PFQPVVLLHI RDVPPADQEK LFIQKLRQCC 
        60         70         80         90        100
VLFDFVSDPL SDLKWKEVKR AALSEMVEYI THNRNVITEP IYPEVVHMFA 
       110        120        130        140        150
VNMFRTLPPS SNPTGAEFDP EEDEPTLEAA WPHLQLVYEF FLRFLESPDF 
       160        170        180        190        200
QPNIAKKYID QKFVLQLLEL FDSEDPRERD FLKTTLHRIY GKFLGLRAYI 
       210        220        230        240        250
RKQINNIFYR FIYETEHHNG IAELLEILGS IINGFALPLK EEHKIFLLKV 
       260        270        280        290        300
LLPLHKVKSL SVYHPQLAYC VVQFLEKDST LTEPVVMALL KYWPKTHSPK 
       310        320        330        340        350
EVMFLNELEE ILDVIEPSEF VKIMEPLFRQ LAKCVSSPHF QVAERALYYW 
       360        370        380        390        400
NNEYIMSLIS DNAAKILPIM FPSLYRNSKT HWNKTIHGLI YNALKLFMEM 
       410        420        430        440        450
NQKLFDDCTQ QFKAEKLKEK LKMKEREEAW VKIENLAKAN PQYTVYSQAS 
       460        470        480        490        500
TMSIPVAMET DGPLFEDVQM LRKTVKDEAH QAQKDPKKDR PLARRKSELP 
       510        520 
QDPHTKKALE AHCRADELAS QDGR
Length:524
Mass (Da):61,061
Last modified:October 17, 2006 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB9CBF54550D713F8
GO
Isoform Gamma-1 (identifier: Q13362-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     443-524: YTVYSQASTM...ADELASQDGR → VLKKRIT

Show »
Length:449
Mass (Da):52,625
Checksum:i73CE22E378289FE8
GO
Isoform Gamma-2 (identifier: Q13362-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     443-481: Missing.

Show »
Length:485
Mass (Da):56,661
Checksum:i64F2D9D78F9D35B6
GO
Isoform 4 (identifier: Q13362-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-31: MLTCNKAGSRMVVDAANSNGPFQPVVLLHIR → MPNKNKKEKE...RELQKLPSLK
     443-481: Missing.

Show »
Length:540
Mass (Da):62,755
Checksum:i30B98C5AED1A4466
GO
Isoform 5 (identifier: Q13362-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-30: MLTCNKAGSRMVVDAANSNGPFQPVVLLHI → MPNKNKKEKE...LVLIFGGLQG

Show »
Length:555
Mass (Da):64,292
Checksum:i1C4C9780CF86FF71
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 16 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q96B13Q96B13_HUMAN
Serine/threonine-protein phosphatas...
PPP2R5C
384Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YJ75H0YJ75_HUMAN
Serine/threonine-protein phosphatas...
PPP2R5C
553Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YJ35H0YJ35_HUMAN
Serine/threonine-protein phosphatas...
PPP2R5C
71Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3V292G3V292_HUMAN
Serine/threonine-protein phosphatas...
PPP2R5C
124Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3V2U3G3V2U3_HUMAN
Serine/threonine-protein phosphatas...
PPP2R5C
216Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YJ49H0YJ49_HUMAN
Serine/threonine-protein phosphatas...
PPP2R5C
151Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YJU0H0YJU0_HUMAN
Serine/threonine-protein phosphatas...
PPP2R5C
153Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YN84H0YN84_HUMAN
Serine/threonine-protein phosphatas...
PPP2R5C
89Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YJZ3H0YJZ3_HUMAN
Serine/threonine-protein phosphatas...
PPP2R5C
69Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YK26H0YK26_HUMAN
Serine/threonine-protein phosphatas...
PPP2R5C
146Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAC50387 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAG63760 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti494R → L in AAC50387 (PubMed:8617797).Curated1
Isoform 5 (identifier: Q13362-5)
Sequence conflicti3N → K in BAG63760 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_051745515A → P. Corresponds to variant dbSNP:rs3742424Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0436451 – 31MLTCN…LLHIR → MPNKNKKEKESPKAGKSGKS SKEGQDTVESEQISVRKNSL VAVPSTVSAKIKVPVSQPIV KKDKRQNSSRFSASNNRELQ KLPSLK in isoform 4. 1 PublicationAdd BLAST31
Alternative sequenceiVSP_0467681 – 30MLTCN…VLLHI → MPNKNKKEKESPKAGKSGKS SKEGQDTVESEGTSPEEPSS PKVPPPLLPELLVLIFGGLQ G in isoform 5. CuratedAdd BLAST30
Alternative sequenceiVSP_005112443 – 524YTVYS…SQDGR → VLKKRIT in isoform Gamma-1. 2 PublicationsAdd BLAST82
Alternative sequenceiVSP_005113443 – 481Missing in isoform Gamma-2 and isoform 4. 2 PublicationsAdd BLAST39

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
U37352 mRNA Translation: AAC50387.1 Different initiation.
Z69030 mRNA Translation: CAA93154.1
AK131391 mRNA Translation: BAD18542.1
AK302470 mRNA Translation: BAG63760.1 Different initiation.
AB451341 mRNA Translation: BAG70155.1
AL118558 Genomic DNA No translation available.
AL137779 Genomic DNA No translation available.
CH471061 Genomic DNA Translation: EAW81756.1
D26445 mRNA Translation: BAA05465.1
L42375 mRNA Translation: AAC37603.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS45163.1 [Q13362-2]
CCDS53911.1 [Q13362-4]
CCDS53912.1 [Q13362-5]
CCDS9964.1 [Q13362-1]
CCDS9965.1 [Q13362-3]

NCBI Reference Sequences

More...RefSeqi		NP_001155197.1, NM_001161725.1 [Q13362-5]
NP_001155198.1, NM_001161726.1 [Q13362-4]
NP_002710.2, NM_002719.3 [Q13362-1]
NP_848701.1, NM_178586.2 [Q13362-3]
NP_848702.1, NM_178587.2 [Q13362-2]
XP_005267884.1, XM_005267827.1
XP_011535222.1, XM_011536920.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000328724; ENSP00000329009; ENSG00000078304 [Q13362-4]
ENST00000334743; ENSP00000333905; ENSG00000078304 [Q13362-1]
ENST00000350249; ENSP00000262239; ENSG00000078304 [Q13362-3]
ENST00000422945; ENSP00000412324; ENSG00000078304 [Q13362-5]
ENST00000445439; ENSP00000408389; ENSG00000078304 [Q13362-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		5527

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:5527

UCSC genome browser

More...UCSCi		uc001ykk.4, human [Q13362-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U37352 mRNA Translation: AAC50387.1 Different initiation.
Z69030 mRNA Translation: CAA93154.1
AK131391 mRNA Translation: BAD18542.1
AK302470 mRNA Translation: BAG63760.1 Different initiation.
AB451341 mRNA Translation: BAG70155.1
AL118558 Genomic DNA No translation available.
AL137779 Genomic DNA No translation available.
CH471061 Genomic DNA Translation: EAW81756.1
D26445 mRNA Translation: BAA05465.1
L42375 mRNA Translation: AAC37603.1
CCDSiCCDS45163.1 [Q13362-2]
CCDS53911.1 [Q13362-4]
CCDS53912.1 [Q13362-5]
CCDS9964.1 [Q13362-1]
CCDS9965.1 [Q13362-3]
RefSeqiNP_001155197.1, NM_001161725.1 [Q13362-5]
NP_001155198.1, NM_001161726.1 [Q13362-4]
NP_002710.2, NM_002719.3 [Q13362-1]
NP_848701.1, NM_178586.2 [Q13362-3]
NP_848702.1, NM_178587.2 [Q13362-2]
XP_005267884.1, XM_005267827.1
XP_011535222.1, XM_011536920.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2IAEX-ray3.50B/E30-436[»]
2JAKX-ray2.60A11-380[»]
2NPPX-ray3.30B/E1-442[»]
2NYLX-ray3.80B/E38-425[»]
2NYMX-ray3.60B/E38-425[»]
3FGAX-ray2.70B34-436[»]
5JJAX-ray2.35A/B30-380[»]
5K6SX-ray2.79A31-380[»]
5SW9X-ray2.85A31-380[»]
5SWFX-ray2.82A31-380[»]
6OYLX-ray3.15A31-380[»]
6VOYelectron microscopy3.70E/F30-372[»]
6VROX-ray2.45A31-380[»]
SMRiQ13362
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi111519, 45 interactors
DIPiDIP-39401N
ELMiQ13362
IntActiQ13362, 29 interactors
MINTiQ13362
STRINGi9606.ENSP00000412324

Chemistry databases

DrugBankiDB06905, (2S,3S,4E,6E,8S,9S)-3-amino-9-methoxy-2,6,8-trimethyl-10-phenyldeca-4,6-dienoic acid
DB02506, 2,6,8-Trimethyl-3-Amino-9-Benzyl-9-Methoxynonanoic Acid

PTM databases

iPTMnetiQ13362
PhosphoSitePlusiQ13362
SwissPalmiQ13362

Polymorphism and mutation databases

BioMutaiPPP2R5C
DMDMi116241235

Proteomic databases

jPOSTiQ13362
MassIVEiQ13362
MaxQBiQ13362
PaxDbiQ13362
PeptideAtlasiQ13362
PRIDEiQ13362
ProteomicsDBi24176
59345
59346 [Q13362-2]
59347 [Q13362-3]
59348 [Q13362-4]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		27667, 234 antibodies

The DNASU plasmid repository

More...DNASUi		5527

Genome annotation databases

EnsembliENST00000328724; ENSP00000329009; ENSG00000078304 [Q13362-4]
ENST00000334743; ENSP00000333905; ENSG00000078304 [Q13362-1]
ENST00000350249; ENSP00000262239; ENSG00000078304 [Q13362-3]
ENST00000422945; ENSP00000412324; ENSG00000078304 [Q13362-5]
ENST00000445439; ENSP00000408389; ENSG00000078304 [Q13362-2]
GeneIDi5527
KEGGihsa:5527
UCSCiuc001ykk.4, human [Q13362-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		5527
DisGeNETi5527
EuPathDBiHostDB:ENSG00000078304.19

GeneCards: human genes, protein and diseases

More...GeneCardsi		PPP2R5C
HGNCiHGNC:9311, PPP2R5C
HPAiENSG00000078304, Low tissue specificity
MIMi601645, gene
neXtProtiNX_Q13362
OpenTargetsiENSG00000078304
PharmGKBiPA33674

Human Unidentified Gene-Encoded large proteins database

More...HUGEi		Search...

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG2085, Eukaryota
GeneTreeiENSGT01010000222363
HOGENOMiCLU_012437_3_2_1
InParanoidiQ13362
OMAiECSQNFN
OrthoDBi890437at2759
PhylomeDBiQ13362
TreeFamiTF105556

Enzyme and pathway databases

PathwayCommonsiQ13362
ReactomeiR-HSA-141444, Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
R-HSA-195253, Degradation of beta-catenin by the destruction complex
R-HSA-196299, Beta-catenin phosphorylation cascade
R-HSA-2467813, Separation of Sister Chromatids
R-HSA-2500257, Resolution of Sister Chromatid Cohesion
R-HSA-389513, CTLA4 inhibitory signaling
R-HSA-432142, Platelet sensitization by LDL
R-HSA-4641262, Disassembly of the destruction complex and recruitment of AXIN to the membrane
R-HSA-5339716, Misspliced GSK3beta mutants stabilize beta-catenin
R-HSA-5358747, S33 mutants of beta-catenin aren't phosphorylated
R-HSA-5358749, S37 mutants of beta-catenin aren't phosphorylated
R-HSA-5358751, S45 mutants of beta-catenin aren't phosphorylated
R-HSA-5358752, T41 mutants of beta-catenin aren't phosphorylated
R-HSA-5467337, APC truncation mutants have impaired AXIN binding
R-HSA-5467340, AXIN missense mutants destabilize the destruction complex
R-HSA-5467348, Truncations of AMER1 destabilize the destruction complex
R-HSA-5663220, RHO GTPases Activate Formins
R-HSA-5673000, RAF activation
R-HSA-5675221, Negative regulation of MAPK pathway
R-HSA-6804757, Regulation of TP53 Degradation
R-HSA-6811558, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
R-HSA-68877, Mitotic Prometaphase
R-HSA-9648025, EML4 and NUDC in mitotic spindle formation
SignaLinkiQ13362
SIGNORiQ13362

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		5527, 19 hits in 846 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		PPP2R5C, human
EvolutionaryTraceiQ13362

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		PPP2R5C

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		5527
PharosiQ13362, Tbio

Protein Ontology

More...PROi		PR:Q13362
RNActiQ13362, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000078304, Expressed in sperm and 244 other tissues
ExpressionAtlasiQ13362, baseline and differential
GenevisibleiQ13362, HS

Family and domain databases

Gene3Di1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR011989, ARM-like
IPR016024, ARM-type_fold
IPR002554, PP2A_B56
PANTHERiPTHR10257, PTHR10257, 1 hit
PfamiView protein in Pfam
PF01603, B56, 1 hit
PIRSFiPIRSF028043, PP2A_B56, 1 hit
SUPFAMiSSF48371, SSF48371, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry namei2A5G_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q13362
Secondary accession number(s): B4DYJ8
, B5BUA5, F5GWP3, Q14391, Q15060, Q15174, Q6ZN33
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: October 17, 2006
Last modified: December 2, 2020
This is version 200 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families
  5. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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