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Entry version 176 (18 Sep 2019)
Sequence version 4 (28 Nov 2012)
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Protein

Zinc finger protein 177

Gene

ZNF177

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri145 – 170C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST26
Zinc fingeri176 – 198C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri256 – 278C2H2-type 3; atypicalPROSITE-ProRule annotationAdd BLAST23
Zinc fingeri284 – 306C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri312 – 334C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri340 – 362C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri368 – 390C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri396 – 418C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri424 – 446C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri452 – 474C2H2-type 10PROSITE-ProRule annotationAdd BLAST23

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

  • negative regulation of transcription by RNA polymerase II Source: ProtInc

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger protein 177
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZNF177
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:12966 ZNF177

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
601276 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q13360

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
7730

Open Targets

More...
OpenTargetsi
ENSG00000188629
ENSG00000270011

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA37548

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ZNF177

Domain mapping of disease mutations (DMDM)

More...
DMDMi
425906076

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000474411 – 481Zinc finger protein 177Add BLAST481

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q13360

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q13360

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q13360

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q13360

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q13360

PeptideAtlas

More...
PeptideAtlasi
Q13360

PRoteomics IDEntifications database

More...
PRIDEi
Q13360

ProteomicsDB human proteome resource

More...
ProteomicsDBi
19656
46361
59343 [Q13360-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q13360

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q13360

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000188629 Expressed in 90 organ(s), highest expression level in right uterine tube

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q13360 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q13360 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA003141

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
ARHGAP21J3JSM93EBI-3921570,EBI-10178656

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
113519, 4 interactors

Protein interaction database and analysis system

More...
IntActi
Q13360, 17 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000468531

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q13360

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini14 – 84KRABPROSITE-ProRule annotationAdd BLAST71

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri145 – 170C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST26
Zinc fingeri176 – 198C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri256 – 278C2H2-type 3; atypicalPROSITE-ProRule annotationAdd BLAST23
Zinc fingeri284 – 306C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri312 – 334C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri340 – 362C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri368 – 390C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri396 – 418C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri424 – 446C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri452 – 474C2H2-type 10PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1721 Eukaryota
COG5048 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000163463

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000234617

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q13360

KEGG Orthology (KO)

More...
KOi
K09228

Identification of Orthologs from Complete Genome Data

More...
OMAi
CIQCEKA

Database of Orthologous Groups

More...
OrthoDBi
1318335at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q13360

Family and domain databases

Conserved Domains Database

More...
CDDi
cd07765 KRAB_A-box, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01352 KRAB, 1 hit
PF00096 zf-C2H2, 4 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 8 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 6 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 7 hits
PS50157 ZINC_FINGER_C2H2_2, 10 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q13360-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAAGWLTTWS QNSVTFQEVA VDFSQEEWAL LDPAQKNLYK DVMLENFRNL
60 70 80 90 100
ASVGYQLCRH SLISKVDQEQ LKTDERGILQ GDCADWETQL KPKDTIAMQN
110 120 130 140 150
IPGGKTSNGI NTAENQPGEH SLECNHCGKF RKNTRFICTR YCKGEKCYKY
160 170 180 190 200
IKYSKVFNHP STLRSHVSIH IGEKTLEFTD CRKAFNQESS LRKHLRTPTG
210 220 230 240 250
QKFQEYEQCD MSFSLHSSCS VREQIPTGEK GDECSDYGKI SPLSVHTKTG
260 270 280 290 300
SVEEGLECNE HEKTFTDPLS LQNCVRTHSG EMPYECSDCG KAFIFQSSLK
310 320 330 340 350
KHMRSHTGEK PYECDHCGKS FSQSSHLNVH KRTHTGEKPY DCKECGKAFT
360 370 380 390 400
VPSSLQKHVR THTGEKPYEC SDCGKAFIDQ SSLKKHTRSH TGEKPYECNQ
410 420 430 440 450
CGKSFSTGSY LIVHKRTHTG EKTYECKECG KAFRNSSCLR VHVRTHTGEK
460 470 480
PYKCIQCEKA FSTSTNLIMH KRIHNGQKLH E
Length:481
Mass (Da):54,782
Last modified:November 28, 2012 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iECC43A8D975F6F90
GO
Isoform 2 (identifier: Q13360-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     113-272: Missing.

Show »
Length:321
Mass (Da):36,409
Checksum:i62BE3432F37067D9
GO
Isoform 3 (identifier: Q13360-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     113-120: AENQPGEH → NPHGREFL
     121-481: Missing.

Show »
Length:120
Mass (Da):13,572
Checksum:i99F27784198CC0F3
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
K7EK36K7EK36_HUMAN
Zinc finger protein 177
ZNF177
126Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EQU1K7EQU1_HUMAN
Zinc finger protein 177
ZNF177
17Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti29A → G in U37251 (PubMed:11549323).Curated1
Sequence conflicti470H → P in AAH12012 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_03169294D → G. Corresponds to variant dbSNP:rs2230750Ensembl.1
Natural variantiVAR_031693112T → M3 PublicationsCorresponds to variant dbSNP:rs2217652Ensembl.1
Natural variantiVAR_057401455I → F2 PublicationsCorresponds to variant dbSNP:rs2230752Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_044461113 – 272Missing in isoform 2. 2 PublicationsAdd BLAST160
Alternative sequenceiVSP_045841113 – 120AENQPGEH → NPHGREFL in isoform 3. 1 Publication8
Alternative sequenceiVSP_045842121 – 481Missing in isoform 3. 1 PublicationAdd BLAST361

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U37263 mRNA Translation: AAB09749.1
U37251 mRNA No translation available.
AK302274 mRNA Translation: BAG63619.1
AC011451 Genomic DNA No translation available.
BC012012 mRNA Translation: AAH12012.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS12212.1 [Q13360-2]
CCDS54214.1 [Q13360-1]
CCDS56081.1 [Q13360-3]

NCBI Reference Sequences

More...
RefSeqi
NP_001166121.1, NM_001172650.2 [Q13360-2]
NP_001166122.1, NM_001172651.1 [Q13360-1]
NP_001189354.1, NM_001202425.1 [Q13360-3]
NP_003442.2, NM_003451.2 [Q13360-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000343499; ENSP00000341497; ENSG00000188629 [Q13360-2]
ENST00000434737; ENSP00000415070; ENSG00000188629 [Q13360-1]
ENST00000589262; ENSP00000468531; ENSG00000188629 [Q13360-1]
ENST00000602856; ENSP00000473272; ENSG00000188629 [Q13360-3]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
100529215
7730

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:100529215
hsa:7730

UCSC genome browser

More...
UCSCi
uc002mlk.4 human [Q13360-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U37263 mRNA Translation: AAB09749.1
U37251 mRNA No translation available.
AK302274 mRNA Translation: BAG63619.1
AC011451 Genomic DNA No translation available.
BC012012 mRNA Translation: AAH12012.1
CCDSiCCDS12212.1 [Q13360-2]
CCDS54214.1 [Q13360-1]
CCDS56081.1 [Q13360-3]
RefSeqiNP_001166121.1, NM_001172650.2 [Q13360-2]
NP_001166122.1, NM_001172651.1 [Q13360-1]
NP_001189354.1, NM_001202425.1 [Q13360-3]
NP_003442.2, NM_003451.2 [Q13360-2]

3D structure databases

SMRiQ13360
ModBaseiSearch...

Protein-protein interaction databases

BioGridi113519, 4 interactors
IntActiQ13360, 17 interactors
STRINGi9606.ENSP00000468531

PTM databases

iPTMnetiQ13360
PhosphoSitePlusiQ13360

Polymorphism and mutation databases

BioMutaiZNF177
DMDMi425906076

Proteomic databases

EPDiQ13360
jPOSTiQ13360
MassIVEiQ13360
MaxQBiQ13360
PaxDbiQ13360
PeptideAtlasiQ13360
PRIDEiQ13360
ProteomicsDBi19656
46361
59343 [Q13360-1]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
7730
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000343499; ENSP00000341497; ENSG00000188629 [Q13360-2]
ENST00000434737; ENSP00000415070; ENSG00000188629 [Q13360-1]
ENST00000589262; ENSP00000468531; ENSG00000188629 [Q13360-1]
ENST00000602856; ENSP00000473272; ENSG00000188629 [Q13360-3]
GeneIDi100529215
7730
KEGGihsa:100529215
hsa:7730
UCSCiuc002mlk.4 human [Q13360-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
100529215
7730
DisGeNETi7730

GeneCards: human genes, protein and diseases

More...
GeneCardsi
ZNF177
HGNCiHGNC:12966 ZNF177
HPAiHPA003141
MIMi601276 gene
neXtProtiNX_Q13360
OpenTargetsiENSG00000188629
ENSG00000270011
PharmGKBiPA37548

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00940000163463
HOGENOMiHOG000234617
InParanoidiQ13360
KOiK09228
OMAiCIQCEKA
OrthoDBi1318335at2759
PhylomeDBiQ13360

Miscellaneous databases

Pharos

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Pharosi
Q13360

Protein Ontology

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PROi
PR:Q13360

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000188629 Expressed in 90 organ(s), highest expression level in right uterine tube
ExpressionAtlasiQ13360 baseline and differential
GenevisibleiQ13360 HS

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
PF00096 zf-C2H2, 4 hits
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 8 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 6 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 7 hits
PS50157 ZINC_FINGER_C2H2_2, 10 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZN177_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q13360
Secondary accession number(s): B4DY57
, E9PDG0, I3L0I4, Q96ER2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 28, 2012
Last modified: September 18, 2019
This is version 176 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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