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Protein

Integrin alpha-D

Gene

ITGAD

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Integrin alpha-D/beta-2 is a receptor for ICAM3 and VCAM1. May play a role in the atherosclerotic process such as clearing lipoproteins from plaques and in phagocytosis of blood-borne pathogens, particulate matter, and senescent erythrocytes from the blood.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi465 – 473Sequence analysis9
Calcium bindingi529 – 537Sequence analysis9
Calcium bindingi592 – 600Sequence analysis9

GO - Molecular functioni

GO - Biological processi

  • extracellular matrix organization Source: Reactome
  • heterotypic cell-cell adhesion Source: UniProtKB
  • immune response Source: UniProtKB
  • integrin-mediated signaling pathway Source: UniProtKB-KW

Keywordsi

Molecular functionIntegrin, Receptor
Biological processCell adhesion
LigandCalcium, Magnesium, Metal-binding

Enzyme and pathway databases

ReactomeiR-HSA-216083 Integrin cell surface interactions
SIGNORiQ13349

Names & Taxonomyi

Protein namesi
Recommended name:
Integrin alpha-D
Alternative name(s):
ADB2
CD11 antigen-like family member D
Leukointegrin alpha D
CD_antigen: CD11d
Gene namesi
Name:ITGAD
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000156886.11
HGNCiHGNC:6146 ITGAD
MIMi602453 gene
neXtProtiNX_Q13349

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini18 – 1099ExtracellularSequence analysisAdd BLAST1082
Transmembranei1100 – 1120HelicalSequence analysisAdd BLAST21
Topological domaini1121 – 1161CytoplasmicSequence analysisAdd BLAST41

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi3681
OpenTargetsiENSG00000156886
PharmGKBiPA29946

Polymorphism and mutation databases

BioMutaiITGAD
DMDMi296434544

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17Sequence analysisAdd BLAST17
ChainiPRO_000001629618 – 1161Integrin alpha-DAdd BLAST1144

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi59N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi67 ↔ 74By similarity
Glycosylationi87N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi99N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi106 ↔ 124By similarity
Glycosylationi391N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi654 ↔ 709By similarity
Glycosylationi690N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi732N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi768 ↔ 774By similarity
Disulfide bondi845 ↔ 860By similarity
Glycosylationi872N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi956N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi993 ↔ 1017By similarity
Disulfide bondi1022 ↔ 1027By similarity
Glycosylationi1045N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ13349
PeptideAtlasiQ13349
PRIDEiQ13349
ProteomicsDBi59334

PTM databases

iPTMnetiQ13349
PhosphoSitePlusiQ13349

Expressioni

Tissue specificityi

Expressed moderately on myelomonocytic cell lines and subsets of peripheral blood leukocytes and strongly on tissue-specialized cells, including macrophages foam cells within atherosclerotic plaques, and on splenic red pulp macrophages.

Gene expression databases

BgeeiENSG00000156886 Expressed in 61 organ(s), highest expression level in spleen
CleanExiHS_ITGAD
GenevisibleiQ13349 HS

Organism-specific databases

HPAiHPA026786

Interactioni

Subunit structurei

Heterodimer of an alpha and a beta subunit. Alpha-D associates with beta-2.

Protein-protein interaction databases

BioGridi109887, 5 interactors
ComplexPortaliCPX-1828 Integrin alphaD-beta2 complex
IntActiQ13349, 1 interactor
STRINGi9606.ENSP00000373854

Structurei

3D structure databases

ProteinModelPortaliQ13349
SMRiQ13349
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati19 – 76FG-GAP 1PROSITE-ProRule annotationAdd BLAST58
Repeati77 – 136FG-GAP 2PROSITE-ProRule annotationAdd BLAST60
Domaini150 – 332VWFAPROSITE-ProRule annotationAdd BLAST183
Repeati339 – 390FG-GAP 3PROSITE-ProRule annotationAdd BLAST52
Repeati391 – 442FG-GAP 4PROSITE-ProRule annotationAdd BLAST52
Repeati443 – 503FG-GAP 5PROSITE-ProRule annotationAdd BLAST61
Repeati506 – 564FG-GAP 6PROSITE-ProRule annotationAdd BLAST59
Repeati569 – 629FG-GAP 7PROSITE-ProRule annotationAdd BLAST61

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi1126 – 1130GFFKR motif5

Domaini

The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage.

Sequence similaritiesi

Belongs to the integrin alpha chain family.Curated

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IPBA Eukaryota
ENOG410ZFBE LUCA
GeneTreeiENSGT00930000150854
HOGENOMiHOG000113114
HOVERGENiHBG100530
InParanoidiQ13349
KOiK06594
OMAiALPECPN
OrthoDBiEOG091G01BZ
PhylomeDBiQ13349
TreeFamiTF105391

Family and domain databases

Gene3Di2.130.10.130, 1 hit
3.40.50.410, 1 hit
InterProiView protein in InterPro
IPR013517 FG-GAP
IPR013519 Int_alpha_beta-p
IPR000413 Integrin_alpha
IPR013649 Integrin_alpha-2
IPR018184 Integrin_alpha_C_CS
IPR028994 Integrin_alpha_N
IPR032695 Integrin_dom_sf
IPR002035 VWF_A
IPR036465 vWFA_dom_sf
PfamiView protein in Pfam
PF01839 FG-GAP, 1 hit
PF00357 Integrin_alpha, 1 hit
PF08441 Integrin_alpha2, 1 hit
PF00092 VWA, 1 hit
PRINTSiPR01185 INTEGRINA
SMARTiView protein in SMART
SM00191 Int_alpha, 5 hits
SM00327 VWA, 1 hit
SUPFAMiSSF53300 SSF53300, 1 hit
SSF69179 SSF69179, 3 hits
PROSITEiView protein in PROSITE
PS51470 FG_GAP, 7 hits
PS00242 INTEGRIN_ALPHA, 1 hit
PS50234 VWFA, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q13349-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTFGTVLLLS VLASYHGFNL DVEEPTIFQE DAGGFGQSVV QFGGSRLVVG
60 70 80 90 100
APLEVVAANQ TGRLYDCAAA TGMCQPIPLH IRPEAVNMSL GLTLAASTNG
110 120 130 140 150
SRLLACGPTL HRVCGENSYS KGSCLLLGSR WEIIQTVPDA TPECPHQEMD
160 170 180 190 200
IVFLIDGSGS IDQNDFNQMK GFVQAVMGQF EGTDTLFALM QYSNLLKIHF
210 220 230 240 250
TFTQFRTSPS QQSLVDPIVQ LKGLTFTATG ILTVVTQLFH HKNGARKSAK
260 270 280 290 300
KILIVITDGQ KYKDPLEYSD VIPQAEKAGI IRYAIGVGHA FQGPTARQEL
310 320 330 340 350
NTISSAPPQD HVFKVDNFAA LGSIQKQLQE KIYAVEGTQS RASSSFQHEM
360 370 380 390 400
SQEGFSTALT MDGLFLGAVG SFSWSGGAFL YPPNMSPTFI NMSQENVDMR
410 420 430 440 450
DSYLGYSTEL ALWKGVQNLV LGAPRYQHTG KAVIFTQVSR QWRKKAEVTG
460 470 480 490 500
TQIGSYFGAS LCSVDVDSDG STDLILIGAP HYYEQTRGGQ VSVCPLPRGR
510 520 530 540 550
VQWQCDAVLR GEQGHPWGRF GAALTVLGDV NEDKLIDVAI GAPGEQENRG
560 570 580 590 600
AVYLFHGASE SGISPSHSQR IASSQLSPRL QYFGQALSGG QDLTQDGLMD
610 620 630 640 650
LAVGARGQVL LLRSLPVLKV GVAMRFSPVE VAKAVYRCWE EKPSALEAGD
660 670 680 690 700
ATVCLTIQKS SLDQLGDIQS SVRFDLALDP GRLTSRAIFN ETKNPTLTRR
710 720 730 740 750
KTLGLGIHCE TLKLLLPDCV EDVVSPIILH LNFSLVREPI PSPQNLRPVL
760 770 780 790 800
AVGSQDLFTA SLPFEKNCGQ DGLCEGDLGV TLSFSGLQTL TVGSSLELNV
810 820 830 840 850
IVTVWNAGED SYGTVVSLYY PAGLSHRRVS GAQKQPHQSA LRLACETVPT
860 870 880 890 900
EDEGLRSSRC SVNHPIFHEG SNGTFIVTFD VSYKATLGDR MLMRASASSE
910 920 930 940 950
NNKASSSKAT FQLELPVKYA VYTMISRQEE STKYFNFATS DEKKMKEAEH
960 970 980 990 1000
RYRVNNLSQR DLAISINFWV PVLLNGVAVW DVVMEAPSQS LPCVSERKPP
1010 1020 1030 1040 1050
QHSDFLTQIS RSPMLDCSIA DCLQFRCDVP SFSVQEELDF TLKGNLSFGW
1060 1070 1080 1090 1100
VRETLQKKVL VVSVAEITFD TSVYSQLPGQ EAFMRAQMEM VLEEDEVYNA
1110 1120 1130 1140 1150
IPIIMGSSVG ALLLLALITA TLYKLGFFKR HYKEMLEDKP EDTATFSGDD
1160
FSCVAPNVPL S
Length:1,161
Mass (Da):126,758
Last modified:May 18, 2010 - v2
Checksum:i769D658010CE5823
GO

Sequence cautioni

The sequence AAB60634 differs from that shown.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti499G → GQ in AAB38547 (PubMed:8777714).Curated1
Sequence conflicti824L → V in AAB60637 (PubMed:8666289).Curated1
Sequence conflicti983V → A in AAB60638 (PubMed:8666289).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U37028 mRNA Translation: AAB38547.1
AF187881 Genomic DNA Translation: AAF62875.1
U40274 Genomic DNA Translation: AAB60634.1 Sequence problems.
U40275 Genomic DNA Translation: AAB60635.1
U40276 Genomic DNA Translation: AAB60636.1
U40277 Genomic DNA Translation: AAB60637.1
U40279, U40278 Genomic DNA Translation: AAB60638.1
CCDSiCCDS32438.1
RefSeqiNP_001305114.1, NM_001318185.1
NP_005344.2, NM_005353.2
UniGeneiHs.679163

Genome annotation databases

EnsembliENST00000389202; ENSP00000373854; ENSG00000156886
GeneIDi3681
KEGGihsa:3681
UCSCiuc002ebv.1 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U37028 mRNA Translation: AAB38547.1
AF187881 Genomic DNA Translation: AAF62875.1
U40274 Genomic DNA Translation: AAB60634.1 Sequence problems.
U40275 Genomic DNA Translation: AAB60635.1
U40276 Genomic DNA Translation: AAB60636.1
U40277 Genomic DNA Translation: AAB60637.1
U40279, U40278 Genomic DNA Translation: AAB60638.1
CCDSiCCDS32438.1
RefSeqiNP_001305114.1, NM_001318185.1
NP_005344.2, NM_005353.2
UniGeneiHs.679163

3D structure databases

ProteinModelPortaliQ13349
SMRiQ13349
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109887, 5 interactors
ComplexPortaliCPX-1828 Integrin alphaD-beta2 complex
IntActiQ13349, 1 interactor
STRINGi9606.ENSP00000373854

PTM databases

iPTMnetiQ13349
PhosphoSitePlusiQ13349

Polymorphism and mutation databases

BioMutaiITGAD
DMDMi296434544

Proteomic databases

PaxDbiQ13349
PeptideAtlasiQ13349
PRIDEiQ13349
ProteomicsDBi59334

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000389202; ENSP00000373854; ENSG00000156886
GeneIDi3681
KEGGihsa:3681
UCSCiuc002ebv.1 human

Organism-specific databases

CTDi3681
DisGeNETi3681
EuPathDBiHostDB:ENSG00000156886.11
GeneCardsiITGAD
H-InvDBiHIX0012989
HIX0134372
HGNCiHGNC:6146 ITGAD
HPAiHPA026786
MIMi602453 gene
neXtProtiNX_Q13349
OpenTargetsiENSG00000156886
PharmGKBiPA29946
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IPBA Eukaryota
ENOG410ZFBE LUCA
GeneTreeiENSGT00930000150854
HOGENOMiHOG000113114
HOVERGENiHBG100530
InParanoidiQ13349
KOiK06594
OMAiALPECPN
OrthoDBiEOG091G01BZ
PhylomeDBiQ13349
TreeFamiTF105391

Enzyme and pathway databases

ReactomeiR-HSA-216083 Integrin cell surface interactions
SIGNORiQ13349

Miscellaneous databases

ChiTaRSiITGAD human
GeneWikiiITGAD
GenomeRNAii3681
PROiPR:Q13349
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000156886 Expressed in 61 organ(s), highest expression level in spleen
CleanExiHS_ITGAD
GenevisibleiQ13349 HS

Family and domain databases

Gene3Di2.130.10.130, 1 hit
3.40.50.410, 1 hit
InterProiView protein in InterPro
IPR013517 FG-GAP
IPR013519 Int_alpha_beta-p
IPR000413 Integrin_alpha
IPR013649 Integrin_alpha-2
IPR018184 Integrin_alpha_C_CS
IPR028994 Integrin_alpha_N
IPR032695 Integrin_dom_sf
IPR002035 VWF_A
IPR036465 vWFA_dom_sf
PfamiView protein in Pfam
PF01839 FG-GAP, 1 hit
PF00357 Integrin_alpha, 1 hit
PF08441 Integrin_alpha2, 1 hit
PF00092 VWA, 1 hit
PRINTSiPR01185 INTEGRINA
SMARTiView protein in SMART
SM00191 Int_alpha, 5 hits
SM00327 VWA, 1 hit
SUPFAMiSSF53300 SSF53300, 1 hit
SSF69179 SSF69179, 3 hits
PROSITEiView protein in PROSITE
PS51470 FG_GAP, 7 hits
PS00242 INTEGRIN_ALPHA, 1 hit
PS50234 VWFA, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiITAD_HUMAN
AccessioniPrimary (citable) accession number: Q13349
Secondary accession number(s): Q15575, Q15576
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 18, 2010
Last modified: November 7, 2018
This is version 168 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
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Main funding by: National Institutes of Health

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