Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Receptor-type tyrosine-protein phosphatase S

Gene

PTPRS

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Cell surface receptor that binds to glycosaminoglycans, including chondroitin sulfate proteoglycans and heparan sulfate proteoglycan (PubMed:21454754). Binding to chondroitin sulfate and heparan sulfate proteoglycans has opposite effects on PTPRS oligomerization and regulation of neurite outgrowth. Contributes to the inhibition of neurite and axonal outgrowth by chondroitin sulfate proteoglycans, also after nerve transection. Plays a role in stimulating neurite outgrowth in response to the heparan sulfate proteoglycan GPC2. Required for normal brain development, especially for normal development of the pituitary gland and the olfactory bulb. Functions as tyrosine phosphatase (PubMed:8524829). Mediates dephosphorylation of NTRK1, NTRK2 and NTRK3 (By similarity). Plays a role in down-regulation of signaling cascades that lead to the activation of Akt and MAP kinases (By similarity). Down-regulates TLR9-mediated activation of NF-kappa-B, as well as production of TNF, interferon alpha and interferon beta (PubMed:26231120).By similarity3 Publications

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation1 Publication1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei1557SubstrateBy similarity1
Active sitei1589Phosphocysteine intermediate1 Publication1
Binding sitei1633SubstrateBy similarity1
Active sitei1880Phosphocysteine intermediateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHeparin-binding, Hydrolase, Protein phosphatase, Receptor
Biological processCell adhesion

Enzyme and pathway databases

BRENDAi3.1.3.48 2681
ReactomeiR-HSA-3000178 ECM proteoglycans
R-HSA-388844 Receptor-type tyrosine-protein phosphatases
R-HSA-8849932 Synaptic adhesion-like molecules
R-HSA-9034015 Signaling by NTRK3 (TRKC)
SIGNORiQ13332

Names & Taxonomyi

Protein namesi
Recommended name:
Receptor-type tyrosine-protein phosphatase S (EC:3.1.3.481 Publication1 Publication)
Short name:
R-PTP-S
Alternative name(s):
Receptor-type tyrosine-protein phosphatase sigma
Short name:
R-PTP-sigma
Gene namesi
Name:PTPRS
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000105426.14
HGNCiHGNC:9681 PTPRS
MIMi601576 gene
neXtProtiNX_Q13332

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini30 – 1282ExtracellularSequence analysisAdd BLAST1253
Transmembranei1283 – 1303HelicalSequence analysisAdd BLAST21
Topological domaini1304 – 1948CytoplasmicSequence analysisAdd BLAST645

Keywords - Cellular componenti

Cell junction, Cell membrane, Cell projection, Cytoplasmic vesicle, Membrane, Postsynaptic cell membrane, Synapse, Synaptosome

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi97R → A: Abolishes interaction with NTRK3; when associated with A-100. 1 Publication1
Mutagenesisi100R → A: Abolishes interaction with NTRK3; when associated with A-97. 1 Publication1
Mutagenesisi233Y → S: Abolishes interaction with NTRK3. 1 Publication1
Mutagenesisi241 – 242RR → AA: Decreases interaction with NTRK3. 1 Publication2

Organism-specific databases

DisGeNETi5802
OpenTargetsiENSG00000105426
PharmGKBiPA34026

Chemistry databases

ChEMBLiCHEMBL2396508
DrugBankiDB00630 Alendronic acid
DB01077 Etidronic acid
GuidetoPHARMACOLOGYi1866

Polymorphism and mutation databases

BioMutaiPTPRS
DMDMi317373519

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 29Sequence analysisAdd BLAST29
ChainiPRO_000002546230 – 1948Receptor-type tyrosine-protein phosphatase SAdd BLAST1919

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi54 ↔ 107PROSITE-ProRule annotationCombined sources2 Publications
Disulfide bondi156 ↔ 216PROSITE-ProRule annotationCombined sources
Glycosylationi263N-linked (GlcNAc...) asparagineCombined sources1 Publication1
Disulfide bondi266 ↔ 311PROSITE-ProRule annotationCombined sources
Glycosylationi308N-linked (GlcNAc...) asparagineCombined sources1 Publication1
Glycosylationi733N-linked (GlcNAc...) asparagine3 Publications1
Glycosylationi940N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

A cleavage occurs, separating the extracellular domain from the transmembrane segment. This process called 'ectodomain shedding' is thought to be involved in receptor desensitization, signal transduction and/or membrane localization (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei1197 – 1198CleavageBy similarity2

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ13332
PaxDbiQ13332
PeptideAtlasiQ13332
PRIDEiQ13332
ProteomicsDBi59320
59321 [Q13332-2]
59322 [Q13332-3]
59323 [Q13332-4]
59324 [Q13332-5]
59325 [Q13332-6]
59326 [Q13332-7]

PTM databases

DEPODiQ13332
iPTMnetiQ13332
PhosphoSitePlusiQ13332

Expressioni

Tissue specificityi

Detected in peripheral blood plasmacytoid dendritic cells (at protein level) (PubMed:26231120). Detected in all tissues tested except for placenta and liver (PubMed:8524829, PubMed:8992885). Detected in peripheral blood plasmacytoid dendritic cells (PubMed:26231120).3 Publications

Gene expression databases

BgeeiENSG00000105426 Expressed in 203 organ(s), highest expression level in forebrain
CleanExiHS_PTPRS
ExpressionAtlasiQ13332 baseline and differential
GenevisibleiQ13332 HS

Organism-specific databases

HPAiHPA054747

Interactioni

Subunit structurei

Binding to large heparan sulfate proteoglycan structures promotes oligomerization. Binding to chondroitin sulfate proteoglycan does not lead to oligomerization (By similarity). Interacts (via Ig-like domains) with NTRK3 (PubMed:25385546). Interacts (via Ig-like domains) with NTRK1, but does not form detectable complexes with NTRK2 (By similarity). Interacts with PPFIA1, PPFIA2 and PPFIA3 (PubMed:8524829, PubMed:9624153).By similarity2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
PTPRNQ168495EBI-711536,EBI-728153

GO - Molecular functioni

Protein-protein interaction databases

BioGridi111766, 59 interactors
IntActiQ13332, 17 interactors
MINTiQ13332
STRINGi9606.ENSP00000349932

Chemistry databases

BindingDBiQ13332

Structurei

Secondary structure

11948
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ13332
SMRiQ13332
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ13332

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini33 – 123Ig-like C2-type 1Add BLAST91
Domaini135 – 233Ig-like C2-type 2Add BLAST99
Domaini245 – 327Ig-like C2-type 3Add BLAST83
Domaini334 – 424Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST91
Domaini429 – 523Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST95
Domaini527 – 616Fibronectin type-III 3PROSITE-ProRule annotationAdd BLAST90
Domaini621 – 718Fibronectin type-III 4PROSITE-ProRule annotationAdd BLAST98
Domaini723 – 831Fibronectin type-III 5PROSITE-ProRule annotationAdd BLAST109
Domaini832 – 930Fibronectin type-III 6PROSITE-ProRule annotationAdd BLAST99
Domaini931 – 1033Fibronectin type-III 7PROSITE-ProRule annotationAdd BLAST103
Domaini1036 – 1120Fibronectin type-III 8PROSITE-ProRule annotationAdd BLAST85
Domaini1393 – 1648Tyrosine-protein phosphatase 1PROSITE-ProRule annotationAdd BLAST256
Domaini1680 – 1939Tyrosine-protein phosphatase 2PROSITE-ProRule annotationAdd BLAST260

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni68 – 72Important for binding to glycosaminoglycan chainsBy similarity5
Regioni1589 – 1595Substrate bindingBy similarity7

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi641 – 644Poly-Pro4

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4228 Eukaryota
COG5599 LUCA
GeneTreeiENSGT00760000118900
HOGENOMiHOG000010250
HOVERGENiHBG053758
InParanoidiQ13332
KOiK06778
OMAiVPGQPMN
OrthoDBiEOG091G11WG
PhylomeDBiQ13332
TreeFamiTF312900

Family and domain databases

CDDicd00063 FN3, 8 hits
Gene3Di2.60.40.10, 11 hits
3.90.190.10, 2 hits
InterProiView protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR029021 Prot-tyrosine_phosphatase-like
IPR000242 PTPase_domain
IPR016130 Tyr_Pase_AS
IPR003595 Tyr_Pase_cat
IPR000387 TYR_PHOSPHATASE_dom
PfamiView protein in Pfam
PF00041 fn3, 7 hits
PF07679 I-set, 2 hits
PF00102 Y_phosphatase, 2 hits
PRINTSiPR00700 PRTYPHPHTASE
SMARTiView protein in SMART
SM00060 FN3, 8 hits
SM00409 IG, 3 hits
SM00408 IGc2, 3 hits
SM00194 PTPc, 2 hits
SM00404 PTPc_motif, 2 hits
SUPFAMiSSF48726 SSF48726, 3 hits
SSF49265 SSF49265, 5 hits
SSF52799 SSF52799, 2 hits
PROSITEiView protein in PROSITE
PS50853 FN3, 8 hits
PS50835 IG_LIKE, 3 hits
PS00383 TYR_PHOSPHATASE_1, 2 hits
PS50056 TYR_PHOSPHATASE_2, 2 hits
PS50055 TYR_PHOSPHATASE_PTP, 2 hits

Sequences (7+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 7 isoformsi produced by alternative splicing. AlignAdd to basket
Note: Additional isoforms seem to exist.

This entry has 7 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q13332-1) [UniParc]FASTAAdd to basket
Also known as: PTPS

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAPTWGPGMV SVVGPMGLLV VLLVGGCAAE EPPRFIKEPK DQIGVSGGVA
60 70 80 90 100
SFVCQATGDP KPRVTWNKKG KKVNSQRFET IEFDESAGAV LRIQPLRTPR
110 120 130 140 150
DENVYECVAQ NSVGEITVHA KLTVLREDQL PSGFPNIDMG PQLKVVERTR
160 170 180 190 200
TATMLCAASG NPDPEITWFK DFLPVDPSAS NGRIKQLRSE TFESTPIRGA
210 220 230 240 250
LQIESSEETD QGKYECVATN SAGVRYSSPA NLYVRELREV RRVAPRFSIL
260 270 280 290 300
PMSHEIMPGG NVNITCVAVG SPMPYVKWMQ GAEDLTPEDD MPVGRNVLEL
310 320 330 340 350
TDVKDSANYT CVAMSSLGVI EAVAQITVKS LPKAPGTPMV TENTATSITI
360 370 380 390 400
TWDSGNPDPV SYYVIEYKSK SQDGPYQIKE DITTTRYSIG GLSPNSEYEI
410 420 430 440 450
WVSAVNSIGQ GPPSESVVTR TGEQAPASAP RNVQARMLSA TTMIVQWEEP
460 470 480 490 500
VEPNGLIRGY RVYYTMEPEH PVGNWQKHNV DDSLLTTVGS LLEDETYTVR
510 520 530 540 550
VLAFTSVGDG PLSDPIQVKT QQGVPGQPMN LRAEARSETS ITLSWSPPRQ
560 570 580 590 600
ESIIKYELLF REGDHGREVG RTFDPTTSYV VEDLKPNTEY AFRLAARSPQ
610 620 630 640 650
GLGAFTPVVR QRTLQSKPSA PPQDVKCVSV RSTAILVSWR PPPPETHNGA
660 670 680 690 700
LVGYSVRYRP LGSEDPEPKE VNGIPPTTTQ ILLEALEKWT QYRITTVAHT
710 720 730 740 750
EVGPGPESSP VVVRTDEDVP SAPPRKVEAE ALNATAIRVL WRSPAPGRQH
760 770 780 790 800
GQIRGYQVHY VRMEGAEARG PPRIKDVMLA DAQWETDDTA EYEMVITNLQ
810 820 830 840 850
PETAYSITVA AYTMKGDGAR SKPKVVVTKG AVLGRPTLSV QQTPEGSLLA
860 870 880 890 900
RWEPPAGTAE DQVLGYRLQF GREDSTPLAT LEFPPSEDRY TASGVHKGAT
910 920 930 940 950
YVFRLAARSR GGLGEEAAEV LSIPEDTPRG HPQILEAAGN ASAGTVLLRW
960 970 980 990 1000
LPPVPAERNG AIVKYTVAVR EAGALGPARE TELPAAAEPG AENALTLQGL
1010 1020 1030 1040 1050
KPDTAYDLQV RAHTRRGPGP FSPPVRYRTF LRDQVSPKNF KVKMIMKTSV
1060 1070 1080 1090 1100
LLSWEFPDNY NSPTPYKIQY NGLTLDVDGR TTKKLITHLK PHTFYNFVLT
1110 1120 1130 1140 1150
NRGSSLGGLQ QTVTAWTAFN LLNGKPSVAP KPDADGFIMV YLPDGQSPVP
1160 1170 1180 1190 1200
VQSYFIVMVP LRKSRGGQFL TPLGSPEDMD LEELIQDISR LQRRSLRHSR
1210 1220 1230 1240 1250
QLEVPRPYIA ARFSVLPPTF HPGDQKQYGG FDNRGLEPGH RYVLFVLAVL
1260 1270 1280 1290 1300
QKSEPTFAAS PFSDPFQLDN PDPQPIVDGE EGLIWVIGPV LAVVFIICIV
1310 1320 1330 1340 1350
IAILLYKNKP DSKRKDSEPR TKCLLNNADL APHHPKDPVE MRRINFQTPD
1360 1370 1380 1390 1400
SGLRSPLREP GFHFESMLSH PPIPIADMAE HTERLKANDS LKLSQEYESI
1410 1420 1430 1440 1450
DPGQQFTWEH SNLEVNKPKN RYANVIAYDH SRVILQPIEG IMGSDYINAN
1460 1470 1480 1490 1500
YVDGYRCQNA YIATQGPLPE TFGDFWRMVW EQRSATIVMM TRLEEKSRIK
1510 1520 1530 1540 1550
CDQYWPNRGT ETYGFIQVTL LDTIELATFC VRTFSLHKNG SSEKREVRQF
1560 1570 1580 1590 1600
QFTAWPDHGV PEYPTPFLAF LRRVKTCNPP DAGPIVVHCS AGVGRTGCFI
1610 1620 1630 1640 1650
VIDAMLERIK PEKTVDVYGH VTLMRSQRNY MVQTEDQYSF IHEALLEAVG
1660 1670 1680 1690 1700
CGNTEVPARS LYAYIQKLAQ VEPGEHVTGM ELEFKRLANS KAHTSRFISA
1710 1720 1730 1740 1750
NLPCNKFKNR LVNIMPYEST RVCLQPIRGV EGSDYINASF IDGYRQQKAY
1760 1770 1780 1790 1800
IATQGPLAET TEDFWRMLWE NNSTIVVMLT KLREMGREKC HQYWPAERSA
1810 1820 1830 1840 1850
RYQYFVVDPM AEYNMPQYIL REFKVTDARD GQSRTVRQFQ FTDWPEQGVP
1860 1870 1880 1890 1900
KSGEGFIDFI GQVHKTKEQF GQDGPISVHC SAGVGRTGVF ITLSIVLERM
1910 1920 1930 1940
RYEGVVDIFQ TVKMLRTQRP AMVQTEDEYQ FCYQAALEYL GSFDHYAT
Length:1,948
Mass (Da):217,041
Last modified:January 11, 2011 - v3
Checksum:iE8BFA76CA410C457
GO
Isoform PTPS-MEA (identifier: Q13332-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     190-198: Missing.

Show »
Length:1,939
Mass (Da):215,980
Checksum:i3EE7153FDA494FD9
GO
Isoform PTPS-MEB (identifier: Q13332-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     236-239: Missing.
     1350-1365: Missing.
     1366-1366: S → G

Show »
Length:1,928
Mass (Da):214,658
Checksum:i6A3B149EF382D202
GO
Isoform PTPS-MEC (identifier: Q13332-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     784-792: Missing.

Show »
Length:1,939
Mass (Da):215,930
Checksum:i63119FAC3E811F31
GO
Isoform PTPS-F4-7 (identifier: Q13332-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     617-1034: Missing.
     1035-1035: V → I

Show »
Length:1,530
Mass (Da):171,838
Checksum:i91EF6825A0AEE9F9
GO
Isoform 2 (identifier: Q13332-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     190-198: Missing.
     236-239: Missing.
     784-792: Missing.
     1350-1365: Missing.
     1366-1366: S → G

Show »
Length:1,910
Mass (Da):212,486
Checksum:i578E617EC9255E5C
GO
Isoform 3 (identifier: Q13332-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     190-198: Missing.
     236-239: Missing.
     617-1034: Missing.
     1035-1035: V → I
     1350-1365: Missing.
     1366-1366: S → G

Show »
Length:1,501
Mass (Da):168,394
Checksum:i8505BCDE81596910
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0A0MR60A0A0A0MR60_HUMAN
Receptor-type tyrosine-protein phos...
PTPRS
1,505Annotation score:
G8JL96G8JL96_HUMAN
Receptor-type tyrosine-protein phos...
PTPRS
1,501Annotation score:
Q8NHS7Q8NHS7_HUMAN
PTPRS protein
PTPRS
128Annotation score:
K7ESP0K7ESP0_HUMAN
Receptor-type tyrosine-protein phos...
PTPRS
90Annotation score:
K7ERX4K7ERX4_HUMAN
Receptor-type tyrosine-protein phos...
PTPRS
79Annotation score:

Sequence cautioni

The sequence AAC50567 differs from that shown. Reason: Frameshift at several positions.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti48G → R in AAC50567 (PubMed:8992885).Curated1
Sequence conflicti428 – 429SA → RP in AAC50567 (PubMed:8992885).Curated2
Sequence conflicti742 – 745RSPA → LGPV in AAC50299 (PubMed:8524829).Curated4
Sequence conflicti765 – 766GA → RR in AAC50567 (PubMed:8992885).Curated2
Sequence conflicti768A → G in AAC50299 (PubMed:8524829).Curated1
Sequence conflicti910R → P in AAC50567 (PubMed:8992885).Curated1
Sequence conflicti995L → V in AAC50299 (PubMed:8524829).Curated1
Sequence conflicti1195 – 1196SL → TV in AAC50299 (PubMed:8524829).Curated2
Sequence conflicti1310 – 1313Missing in AAC62834 (PubMed:15057824).Curated4
Sequence conflicti1431S → F in AAC50299 (PubMed:8524829).Curated1
Sequence conflicti1546E → D in AAB21146 (PubMed:1370651).Curated1
Sequence conflicti1587V → A in AAB21146 (PubMed:1370651).Curated1
Sequence conflicti1705N → K in AAC50567 (PubMed:8992885).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_035649996T → M in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs775778266Ensembl.1
Natural variantiVAR_0472771457C → R4 PublicationsCorresponds to variant dbSNP:rs4807697Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_050021190 – 198Missing in isoform PTPS-MEA, isoform 2 and isoform 3. 2 Publications9
Alternative sequenceiVSP_050022236 – 239Missing in isoform PTPS-MEB, isoform 2 and isoform 3. 2 Publications4
Alternative sequenceiVSP_050023617 – 1034Missing in isoform PTPS-F4-7 and isoform 3. 1 PublicationAdd BLAST418
Alternative sequenceiVSP_050024784 – 792Missing in isoform PTPS-MEC and isoform 2. 1 Publication9
Alternative sequenceiVSP_0500251035V → I in isoform PTPS-F4-7 and isoform 3. 1 Publication1
Alternative sequenceiVSP_0500261350 – 1365Missing in isoform PTPS-MEB, isoform 2 and isoform 3. 2 PublicationsAdd BLAST16
Alternative sequenceiVSP_0500271366S → G in isoform PTPS-MEB, isoform 2 and isoform 3. 2 Publications1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U35234 mRNA Translation: AAC50299.1
U40317 mRNA Translation: AAC50567.1 Frameshift.
AC005335 Genomic DNA No translation available.
AC005790 Genomic DNA Translation: AAC62832.1
AC005338 Genomic DNA Translation: AAC27825.1
AC005788 Genomic DNA Translation: AAC62834.1
AC118535 Genomic DNA No translation available.
CH471139 Genomic DNA Translation: EAW69176.1
BC104812 mRNA Translation: AAI04813.1
BC143287 mRNA Translation: AAI43288.1
S78080 mRNA Translation: AAB21146.2
CCDSiCCDS12139.1 [Q13332-7]
CCDS12140.1 [Q13332-6]
CCDS45930.1 [Q13332-1]
RefSeqiNP_002841.3, NM_002850.3 [Q13332-1]
NP_570923.2, NM_130853.2 [Q13332-7]
NP_570924.2, NM_130854.2 [Q13332-6]
NP_570925.2, NM_130855.2
XP_005259663.1, XM_005259606.2 [Q13332-6]
XP_005259666.1, XM_005259609.1 [Q13332-7]
XP_016882554.1, XM_017027065.1 [Q13332-2]
XP_016882555.1, XM_017027066.1 [Q13332-2]
XP_016882556.1, XM_017027067.1 [Q13332-2]
UniGeneiHs.744928

Genome annotation databases

EnsembliENST00000587303; ENSP00000467537; ENSG00000105426 [Q13332-1]
ENST00000588012; ENSP00000465443; ENSG00000105426 [Q13332-6]
ENST00000592099; ENSP00000467398; ENSG00000105426 [Q13332-7]
GeneIDi5802
KEGGihsa:5802
UCSCiuc002mbv.3 human [Q13332-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U35234 mRNA Translation: AAC50299.1
U40317 mRNA Translation: AAC50567.1 Frameshift.
AC005335 Genomic DNA No translation available.
AC005790 Genomic DNA Translation: AAC62832.1
AC005338 Genomic DNA Translation: AAC27825.1
AC005788 Genomic DNA Translation: AAC62834.1
AC118535 Genomic DNA No translation available.
CH471139 Genomic DNA Translation: EAW69176.1
BC104812 mRNA Translation: AAI04813.1
BC143287 mRNA Translation: AAI43288.1
S78080 mRNA Translation: AAB21146.2
CCDSiCCDS12139.1 [Q13332-7]
CCDS12140.1 [Q13332-6]
CCDS45930.1 [Q13332-1]
RefSeqiNP_002841.3, NM_002850.3 [Q13332-1]
NP_570923.2, NM_130853.2 [Q13332-7]
NP_570924.2, NM_130854.2 [Q13332-6]
NP_570925.2, NM_130855.2
XP_005259663.1, XM_005259606.2 [Q13332-6]
XP_005259666.1, XM_005259609.1 [Q13332-7]
XP_016882554.1, XM_017027065.1 [Q13332-2]
XP_016882555.1, XM_017027066.1 [Q13332-2]
XP_016882556.1, XM_017027067.1 [Q13332-2]
UniGeneiHs.744928

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2FH7X-ray2.00A1365-1948[»]
2YD2X-ray2.55A30-244[»]
2YD3X-ray2.30A30-235[»]
2YD9X-ray2.60A30-334[»]
4BPCX-ray2.10A1367-1948[»]
4PBXX-ray3.15A30-614[»]
ProteinModelPortaliQ13332
SMRiQ13332
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111766, 59 interactors
IntActiQ13332, 17 interactors
MINTiQ13332
STRINGi9606.ENSP00000349932

Chemistry databases

BindingDBiQ13332
ChEMBLiCHEMBL2396508
DrugBankiDB00630 Alendronic acid
DB01077 Etidronic acid
GuidetoPHARMACOLOGYi1866

PTM databases

DEPODiQ13332
iPTMnetiQ13332
PhosphoSitePlusiQ13332

Polymorphism and mutation databases

BioMutaiPTPRS
DMDMi317373519

Proteomic databases

MaxQBiQ13332
PaxDbiQ13332
PeptideAtlasiQ13332
PRIDEiQ13332
ProteomicsDBi59320
59321 [Q13332-2]
59322 [Q13332-3]
59323 [Q13332-4]
59324 [Q13332-5]
59325 [Q13332-6]
59326 [Q13332-7]

Protocols and materials databases

DNASUi5802
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000587303; ENSP00000467537; ENSG00000105426 [Q13332-1]
ENST00000588012; ENSP00000465443; ENSG00000105426 [Q13332-6]
ENST00000592099; ENSP00000467398; ENSG00000105426 [Q13332-7]
GeneIDi5802
KEGGihsa:5802
UCSCiuc002mbv.3 human [Q13332-1]

Organism-specific databases

CTDi5802
DisGeNETi5802
EuPathDBiHostDB:ENSG00000105426.14
GeneCardsiPTPRS
HGNCiHGNC:9681 PTPRS
HPAiHPA054747
MIMi601576 gene
neXtProtiNX_Q13332
OpenTargetsiENSG00000105426
PharmGKBiPA34026
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4228 Eukaryota
COG5599 LUCA
GeneTreeiENSGT00760000118900
HOGENOMiHOG000010250
HOVERGENiHBG053758
InParanoidiQ13332
KOiK06778
OMAiVPGQPMN
OrthoDBiEOG091G11WG
PhylomeDBiQ13332
TreeFamiTF312900

Enzyme and pathway databases

BRENDAi3.1.3.48 2681
ReactomeiR-HSA-3000178 ECM proteoglycans
R-HSA-388844 Receptor-type tyrosine-protein phosphatases
R-HSA-8849932 Synaptic adhesion-like molecules
R-HSA-9034015 Signaling by NTRK3 (TRKC)
SIGNORiQ13332

Miscellaneous databases

ChiTaRSiPTPRS human
EvolutionaryTraceiQ13332
GeneWikiiPTPRS
GenomeRNAii5802
PROiPR:Q13332
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000105426 Expressed in 203 organ(s), highest expression level in forebrain
CleanExiHS_PTPRS
ExpressionAtlasiQ13332 baseline and differential
GenevisibleiQ13332 HS

Family and domain databases

CDDicd00063 FN3, 8 hits
Gene3Di2.60.40.10, 11 hits
3.90.190.10, 2 hits
InterProiView protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR029021 Prot-tyrosine_phosphatase-like
IPR000242 PTPase_domain
IPR016130 Tyr_Pase_AS
IPR003595 Tyr_Pase_cat
IPR000387 TYR_PHOSPHATASE_dom
PfamiView protein in Pfam
PF00041 fn3, 7 hits
PF07679 I-set, 2 hits
PF00102 Y_phosphatase, 2 hits
PRINTSiPR00700 PRTYPHPHTASE
SMARTiView protein in SMART
SM00060 FN3, 8 hits
SM00409 IG, 3 hits
SM00408 IGc2, 3 hits
SM00194 PTPc, 2 hits
SM00404 PTPc_motif, 2 hits
SUPFAMiSSF48726 SSF48726, 3 hits
SSF49265 SSF49265, 5 hits
SSF52799 SSF52799, 2 hits
PROSITEiView protein in PROSITE
PS50853 FN3, 8 hits
PS50835 IG_LIKE, 3 hits
PS00383 TYR_PHOSPHATASE_1, 2 hits
PS50056 TYR_PHOSPHATASE_2, 2 hits
PS50055 TYR_PHOSPHATASE_PTP, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiPTPRS_HUMAN
AccessioniPrimary (citable) accession number: Q13332
Secondary accession number(s): O75255
, O75870, Q15718, Q16341, Q2M3R7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2003
Last sequence update: January 11, 2011
Last modified: October 10, 2018
This is version 185 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. SIMILARITY comments
    Index of protein domains and families
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again