SGCG

Functionⁱ

Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix.

GO - Biological processⁱ

cardiac muscle tissue development Source: GO_Central
heart contraction Source: GO_Central
membrane organization Source: GO_Central
muscle cell development Source: GO_Central
muscle organ development
Source: ProtInc
Traceable author statementⁱ
- 8641426

View the complete GO annotation on QuickGO ...

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Gamma-sarcoglycan Short name: Gamma-SG Alternative name(s): 35 kDa dystrophin-associated glycoprotein Short name: 35DAG
Gene namesⁱ	Name:SGCG
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 13

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000102683.7
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:10809 SGCG
MIMⁱ	608896 gene
neXtProtⁱ	NX_Q13326

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 37	CytoplasmicSequence analysisAdd BLAST	37
Transmembraneⁱ	38 – 58	Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST	21
Topological domainⁱ	59 – 291	ExtracellularSequence analysisAdd BLAST	233

Keywords - Cellular componentⁱ

Cell membrane, Cytoplasm, Cytoskeleton, Membrane

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Limb-girdle muscular dystrophy 2C (LGMD2C)2 Publications

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionAn autosomal recessive degenerative myopathy characterized by rapidly progressive muscle wasting from early childhood with loss of independent ambulation around age 12 years, dystrophic pattern on muscle biopsy, absence of gamma-sarcoglycan and normal dystrophin immunostaining.

Keywords - Diseaseⁱ

Disease mutation, Limb-girdle muscular dystrophy

Organism-specific databases

DisGeNET More...DisGeNETⁱ	6445
MalaCards human disease database More...MalaCardsⁱ	SGCG
MIMⁱ	253700 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000102683
Orphanetⁱ	353 Autosomal recessive limb-girdle muscular dystrophy type 2C
PharmGKBⁱ	PA35720

Polymorphism and mutation databases

BioMutaⁱ	SGCG
DMDMⁱ	313104319

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000175248	1 – 291	Gamma-sarcoglycanAdd BLAST		291

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	110	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	265 ↔ 290	Sequence analysis
Disulfide bondⁱ	267 ↔ 283	Sequence analysis

Keywords - PTMⁱ

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbⁱ	Q13326
PeptideAtlas More...PeptideAtlasⁱ	Q13326
PRIDEⁱ	Q13326
ProteomicsDBⁱ	59316

PTM databases

PhosphoSitePlusⁱ	Q13326

PhosphoSitePlusⁱ

Q13326

Expressionⁱ

Tissue specificityⁱ

Expressed in skeletal and heart muscle.

Gene expression databases

Bgeeⁱ	ENSG00000102683
CleanExⁱ	HS_SGCG
Genevisibleⁱ	Q13326 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA007476 HPA011922

HPAⁱ

HPA007476
HPA011922

Interactionⁱ

Subunit structureⁱ

Interacts with the syntrophin SNTA1. Cross-link to form 2 major subcomplexes: one consisting of SGCB, SGCD and SGCG and the other consisting of SGCB and SGCD. The association between SGCB and SGCG is particularly strong while SGCA is loosely associated with the other sarcoglycans (By similarity). Interacts with FLNC.By similarity1 Publication

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
ACO1	P21399	2	EBI-5357343,EBI-2847111
DNAJB6	O75190	2	EBI-5357343,EBI-1053164
DYSF	O75923	3	EBI-5357343,EBI-2799016

Show more details

Protein-protein interaction databases

BioGridⁱ	112343, 2 interactors
CORUMⁱ	Q13326
IntActⁱ	Q13326, 16 interactors
Molecular INTeraction database More...MINTⁱ	Q13326
STRINGⁱ	9606.ENSP00000218867

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q13326
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the sarcoglycan beta/delta/gamma/zeta family.Curated

Keywords - Domainⁱ

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG3950 Eukaryota ENOG4111GCH LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000017950
HOGENOMⁱ	HOG000007853
HOVERGENⁱ	HBG008669
InParanoidⁱ	Q13326
KEGG Orthology (KO) More...KOⁱ	K12564
OMAⁱ	DAETVCL
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G11VY
PhylomeDBⁱ	Q13326
TreeFamⁱ	TF313538

Family and domain databases

InterProⁱ	View protein in InterPro IPR006875 Sarcoglycan IPR027660 SGCG
PANTHERⁱ	PTHR12939:SF4 PTHR12939:SF4, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF04790 Sarcoglycan_1, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Q13326-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MVREQYTTAT EGICIERPEN QYVYKIGIYG WRKRCLYLFV LLLLIILVVN 
        60         70         80         90        100
LALTIWILKV MWFSPAGMGH LCVTKDGLRL EGESEFLFPL YAKEIHSRVD 
       110        120        130        140        150
SSLLLQSTQN VTVNARNSEG EVTGRLKVGP KMVEVQNQQF QINSNDGKPL 
       160        170        180        190        200
FTVDEKEVVV GTDKLRVTGP EGALFEHSVE TPLVRADPFQ DLRLESPTRS 
       210        220        230        240        250
LSMDAPRGVH IQAHAGKIEA LSQMDILFHS SDGMLVLDAE TVCLPKLVQG 
       260        270        280        290 
TWGPSGSSQS LYEICVCPDG KLYLSVAGVS TTCQEHNHIC L

Length:291

Mass (Da):32,379

Last modified:November 30, 2010 - v4

Checksum:ⁱ6CF219706ABFB77B

GO

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_010430	69	G → D in LGMD2C.	1
Natural variantⁱVAR_012202	69	G → R in LGMD2C. 1 Publication	1
Natural variantⁱVAR_010397	116	R → H1 PublicationCorresponds to variant dbSNP:rs17314986EnsemblClinVar.	1
Natural variantⁱVAR_010398	283	C → Y in LGMD2C. 1 PublicationCorresponds to variant dbSNP:rs104894422EnsemblClinVar.	1
Natural variantⁱVAR_010399	287	N → S3 PublicationsCorresponds to variant dbSNP:rs1800354Ensembl.	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U34976 mRNA Translation: AAC50269.1 U63395 U63394 Genomic DNA Translation: AAD13475.1 AL157766 Genomic DNA No translation available. AL356287 Genomic DNA No translation available. AL160256 Genomic DNA No translation available. BC074777 mRNA Translation: AAH74777.1 BC074778 mRNA Translation: AAH74778.1 BC109321 mRNA Translation: AAI09322.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS9299.1
NCBI Reference Sequences More...RefSeqⁱ	NP_000222.1, NM_000231.2 XP_005266562.1, XM_005266505.2
UniGeneⁱ	Hs.37167

Genome annotation databases

Ensemblⁱ	ENST00000218867; ENSP00000218867; ENSG00000102683
GeneIDⁱ	6445
KEGGⁱ	hsa:6445
UCSC genome browser More...UCSCⁱ	uc001uom.3 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length
Q13326	UPI0003EAFB21		HUMAN		309
UPI0005F4F94D		CERAT		309
Sarcoglycan gamma		RHIRO		308
Gamma-sarcoglycan		MACMU		291
Gamma-sarcoglycan		MACFA		291
+6

Protein	Similar proteins		Species	Score	Length
Q13326	UPI0003EAFB21		HUMAN		309
UPI0005F4F94D		CERAT		309
Sarcoglycan gamma		RHIRO		308
Gamma-sarcoglycan		MACMU		291
Gamma-sarcoglycan		MACFA		291
+21

Cross-referencesⁱ

Web resourcesⁱ

Leiden Muscular Dystrophy pages

SGCG mutations in LGMD2C

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U34976 mRNA Translation: AAC50269.1 U63395 U63394 Genomic DNA Translation: AAD13475.1 AL157766 Genomic DNA No translation available. AL356287 Genomic DNA No translation available. AL160256 Genomic DNA No translation available. BC074777 mRNA Translation: AAH74777.1 BC074778 mRNA Translation: AAH74778.1 BC109321 mRNA Translation: AAI09322.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS9299.1
NCBI Reference Sequences More...RefSeqⁱ	NP_000222.1, NM_000231.2 XP_005266562.1, XM_005266505.2
UniGeneⁱ	Hs.37167

3D structure databases

ProteinModelPortalⁱ	Q13326
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	112343, 2 interactors
CORUMⁱ	Q13326
IntActⁱ	Q13326, 16 interactors
Molecular INTeraction database More...MINTⁱ	Q13326
STRINGⁱ	9606.ENSP00000218867

PTM databases

PhosphoSitePlusⁱ	Q13326

PhosphoSitePlusⁱ

Q13326

Polymorphism and mutation databases

BioMutaⁱ	SGCG
DMDMⁱ	313104319

Proteomic databases

PaxDbⁱ	Q13326
PeptideAtlas More...PeptideAtlasⁱ	Q13326
PRIDEⁱ	Q13326
ProteomicsDBⁱ	59316

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	6445
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000218867; ENSP00000218867; ENSG00000102683
GeneIDⁱ	6445
KEGGⁱ	hsa:6445
UCSC genome browser More...UCSCⁱ	uc001uom.3 human

Organism-specific databases

CTDⁱ	6445
DisGeNET More...DisGeNETⁱ	6445
EuPathDBⁱ	HostDB:ENSG00000102683.7
GeneCardsⁱ	SGCG
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:10809 SGCG
Human Protein Atlas More...HPAⁱ	HPA007476 HPA011922
MalaCards human disease database More...MalaCardsⁱ	SGCG
MIMⁱ	253700 phenotype 608896 gene
neXtProtⁱ	NX_Q13326
Open Targets More...OpenTargetsⁱ	ENSG00000102683
Orphanetⁱ	353 Autosomal recessive limb-girdle muscular dystrophy type 2C
PharmGKBⁱ	PA35720
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3950 Eukaryota ENOG4111GCH LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000017950
HOGENOMⁱ	HOG000007853
HOVERGENⁱ	HBG008669
InParanoidⁱ	Q13326
KEGG Orthology (KO) More...KOⁱ	K12564
OMAⁱ	DAETVCL
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G11VY
PhylomeDBⁱ	Q13326
TreeFamⁱ	TF313538

Miscellaneous databases

ChiTaRSⁱ	SGCG human
GeneWikiⁱ	SGCG
GenomeRNAiⁱ	6445
Protein Ontology More...PROⁱ	PR:Q13326
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000102683
CleanExⁱ	HS_SGCG
Genevisibleⁱ	Q13326 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR006875 Sarcoglycan IPR027660 SGCG
PANTHERⁱ	PTHR12939:SF4 PTHR12939:SF4, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF04790 Sarcoglycan_1, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	SGCG_HUMAN
Accessionⁱ	Q13326Primary (citable) accession number: Q13326 Secondary accession number(s): Q32M32, Q5T9J6
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	April 27, 2001
	Last sequence update:	November 30, 2010
	Last modified:	June 20, 2018
	This is version 160 of the entry and version 4 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

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UniProtKB - Q13326 (SGCG_HUMAN)

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Gamma-sarcoglycan

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Cytoskeleton

Cytoskeleton

Nucleus

Plasma Membrane

Other locations

Topology

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Natural variant

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ