UniProtKB - Q13324 (CRFR2_HUMAN)
Corticotropin-releasing factor receptor 2
CRHR2
Functioni
GO - Molecular functioni
- corticotrophin-releasing factor receptor activity Source: GO_Central
- corticotropin-releasing hormone receptor activity Source: GO_Central
- G protein-coupled peptide receptor activity Source: GO_Central
- peptide hormone binding Source: GO_Central
GO - Biological processi
- adenylate cyclase-modulating G protein-coupled receptor signaling pathway Source: GO_Central
- cell surface receptor signaling pathway Source: InterPro
- G protein-coupled receptor signaling pathway Source: Reactome
- long-term synaptic potentiation Source: GO_Central
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Enzyme and pathway databases
PathwayCommonsi | Q13324 |
Reactomei | R-HSA-373080, Class B/2 (Secretin family receptors) R-HSA-418555, G alpha (s) signalling events R-HSA-422085, Synthesis, secretion, and deacylation of Ghrelin R-HSA-9660821, ADORA2B mediated anti-inflammatory cytokines production |
Names & Taxonomyi
Protein namesi | Recommended name: Corticotropin-releasing factor receptor 2Short name: CRF-R-2 Short name: CRF-R2 Short name: CRFR-2 Alternative name(s): Corticotropin-releasing hormone receptor 2 Short name: CRH-R-2 Short name: CRH-R2 |
Gene namesi | Name:CRHR2 Synonyms:CRF2R, CRH2R |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000106113.18 |
HGNCi | HGNC:2358, CRHR2 |
MIMi | 602034, gene |
neXtProti | NX_Q13324 |
Subcellular locationi
Plasma membrane
- Cell membrane 1 Publication; Multi-pass membrane protein 1 Publication
Plasma Membrane
- integral component of plasma membrane Source: ProtInc
- plasma membrane Source: GO_Central
Other locations
- axon terminus Source: GO_Central
- dendrite Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 108 | ExtracellularBy similarityAdd BLAST | 108 | |
Transmembranei | 109 – 139 | Helical; Name=1By similarityAdd BLAST | 31 | |
Topological domaini | 140 – 146 | CytoplasmicBy similarity | 7 | |
Transmembranei | 147 – 171 | Helical; Name=2By similarityAdd BLAST | 25 | |
Topological domaini | 172 – 185 | ExtracellularBy similarityAdd BLAST | 14 | |
Transmembranei | 186 – 214 | Helical; Name=3By similarityAdd BLAST | 29 | |
Topological domaini | 215 – 221 | CytoplasmicBy similarity | 7 | |
Transmembranei | 222 – 249 | Helical; Name=4By similarityAdd BLAST | 28 | |
Topological domaini | 250 – 265 | ExtracellularBy similarityAdd BLAST | 16 | |
Transmembranei | 266 – 291 | Helical; Name=5By similarityAdd BLAST | 26 | |
Topological domaini | 292 – 302 | CytoplasmicBy similarityAdd BLAST | 11 | |
Transmembranei | 303 – 327 | Helical; Name=6By similarityAdd BLAST | 25 | |
Topological domaini | 328 – 334 | ExtracellularBy similarity | 7 | |
Transmembranei | 335 – 364 | Helical; Name=7By similarityAdd BLAST | 30 | |
Topological domaini | 365 – 411 | CytoplasmicBy similarityAdd BLAST | 47 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 1395 |
OpenTargetsi | ENSG00000106113 |
PharmGKBi | PA26875 |
Miscellaneous databases
Pharosi | Q13324, Tbio |
Chemistry databases
ChEMBLi | CHEMBL4069 |
DrugCentrali | Q13324 |
GuidetoPHARMACOLOGYi | 213 |
Polymorphism and mutation databases
BioMutai | CRHR2 |
DMDMi | 6226847 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000012820 | 1 – 411 | Corticotropin-releasing factor receptor 2Add BLAST | 411 | |
Signal peptidei | 1 – 19 | Not cleavedAdd BLAST | 19 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length | |
---|---|---|---|---|---|
Glycosylationi | 13 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | ||
Disulfide bondi | 14 ↔ 50 | 1 Publication | |||
Disulfide bondi | 40 ↔ 83 | 1 Publication | |||
Glycosylationi | 41 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | ||
Disulfide bondi | 64 ↔ 98 | 1 Publication | |||
Glycosylationi | 74 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | ||
Glycosylationi | 86 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | ||
Glycosylationi | 94 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | ||
Disulfide bondi | 184 ↔ 254 | By similarity | |||
Isoform CRF2-beta (identifier: Q13324-2) | |||||
Disulfide bondi | 51 ↔ 77 | Curated |
Post-translational modificationi
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
PaxDbi | Q13324 |
PeptideAtlasi | Q13324 |
PRIDEi | Q13324 |
ProteomicsDBi | 30449 59312 [Q13324-1] 59313 [Q13324-2] 59314 [Q13324-3] |
PTM databases
GlyGeni | Q13324, 5 sites |
PhosphoSitePlusi | Q13324 |
Expressioni
Gene expression databases
Bgeei | ENSG00000106113, Expressed in frontal cortex and 107 other tissues |
ExpressionAtlasi | Q13324, baseline and differential |
Genevisiblei | Q13324, HS |
Organism-specific databases
HPAi | ENSG00000106113, Tissue enhanced (brain) |
Interactioni
Subunit structurei
Monomer.
Interacts (via N-terminal extracellular domain) with CRF, UCN, UCN2 and UCN3. Has highest affinity for UCN, and considerably lower affinity for CRF, UNC2 and UCN3.
2 PublicationsBinary interactionsi
Isoform CRF2-beta [Q13324-2]
With | #Exp. | IntAct |
---|---|---|
MALL [Q13021] | 3 | EBI-23865243,EBI-750078 |
Protein-protein interaction databases
BioGRIDi | 107785, 3 interactors |
IntActi | Q13324, 2 interactors |
MINTi | Q13324 |
STRINGi | 9606.ENSP00000340943 |
Chemistry databases
BindingDBi | Q13324 |
Miscellaneous databases
RNActi | Q13324, protein |
Structurei
Secondary structure
3D structure databases
SMRi | Q13324 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q13324 |
Family & Domainsi
Domaini
Sequence similaritiesi
Keywords - Domaini
Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG4564, Eukaryota |
GeneTreei | ENSGT00940000156795 |
HOGENOMi | CLU_002753_4_1_1 |
InParanoidi | Q13324 |
OMAi | EFDVNCS |
OrthoDBi | 1163977at2759 |
PhylomeDBi | Q13324 |
TreeFami | TF315710 |
Family and domain databases
Gene3Di | 4.10.1240.10, 1 hit |
InterProi | View protein in InterPro IPR017981, GPCR_2-like IPR003053, GPCR_2_CRF2_rcpt IPR003051, GPCR_2_CRF_rcpt IPR036445, GPCR_2_extracell_dom_sf IPR001879, GPCR_2_extracellular_dom IPR000832, GPCR_2_secretin-like IPR017983, GPCR_2_secretin-like_CS |
Pfami | View protein in Pfam PF00002, 7tm_2, 1 hit PF02793, HRM, 1 hit |
PRINTSi | PR01279, CRFRECEPTOR PR01281, CRFRECEPTOR2 PR00249, GPCRSECRETIN |
SMARTi | View protein in SMART SM00008, HormR, 1 hit |
SUPFAMi | SSF111418, SSF111418, 1 hit |
PROSITEi | View protein in PROSITE PS00649, G_PROTEIN_RECEP_F2_1, 1 hit PS00650, G_PROTEIN_RECEP_F2_2, 1 hit PS50227, G_PROTEIN_RECEP_F2_3, 1 hit PS50261, G_PROTEIN_RECEP_F2_4, 1 hit |
s (7+)i Sequence
Sequence statusi: Complete.
This entry describes 7 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 7 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MDAALLHSLL EANCSLALAE ELLLDGWGPP LDPEGPYSYC NTTLDQIGTC
60 70 80 90 100
WPRSAAGALV ERPCPEYFNG VKYNTTRNAY RECLENGTWA SKINYSQCEP
110 120 130 140 150
ILDDKQRKYD LHYRIALVVN YLGHCVSVAA LVAAFLLFLA LRSIRCLRNV
160 170 180 190 200
IHWNLITTFI LRNVMWFLLQ LVDHEVHESN EVWCRCITTI FNYFVVTNFF
210 220 230 240 250
WMFVEGCYLH TAIVMTYSTE RLRKCLFLFI GWCIPFPIIV AWAIGKLYYE
260 270 280 290 300
NEQCWFGKEP GDLVDYIYQG PIILVLLINF VFLFNIVRIL MTKLRASTTS
310 320 330 340 350
ETIQYRKAVK ATLVLLPLLG ITYMLFFVNP GEDDLSQIMF IYFNSFLQSF
360 370 380 390 400
QGFFVSVFYC FFNGEVRSAV RKRWHRWQDH HSLRVPMARA MSIPTSPTRI
410
SFHSIKQTAA V
The sequence of this isoform differs from the canonical sequence as follows:
1-34: MDAALLHSLLEANCSLALAEELLLDGWGPPLDPE → MRGPSGPPGL...HTIMTLTNLS
The sequence of this isoform differs from the canonical sequence as follows:
1-34: MDAALLHSLLEANCSLALAEELLLDGWGPPLDPE → MGREPWPEDRDLGFPQLFCQ
The sequence of this isoform differs from the canonical sequence as follows:
106-106: Missing.
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketC9JZM9 | C9JZM9_HUMAN | Corticotropin-releasing factor rece... | CRHR2 | 99 | Annotation score: | ||
F2Z2M6 | F2Z2M6_HUMAN | Corticotropin-releasing factor rece... | CRHR2 | 64 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 185 | R → H in AAA91320 (PubMed:8536644).Curated | 1 | |
Sequence conflicti | 185 | R → H in ABV59313 (Ref. 6) Curated | 1 | |
Sequence conflicti | 185 | R → H in ABV59314 (Ref. 6) Curated | 1 | |
Sequence conflicti | 185 | R → H in ABV59315 (Ref. 6) Curated | 1 | |
Sequence conflicti | 185 | R → H in ABV59317 (Ref. 6) Curated | 1 | |
Sequence conflicti | 374 | W → R in BAG36414 (PubMed:14702039).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_049455 | 220 | E → D. Corresponds to variant dbSNP:rs34625936Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_001999 | 1 – 34 | MDAAL…PLDPE → MRGPSGPPGLLYVPHLLLCL LCLLPPPLQYAAGQSQMPKD QPLWALLEQYCHTIMTLTNL S in isoform CRF2-beta. 2 PublicationsAdd BLAST | 34 | |
Alternative sequenceiVSP_002000 | 1 – 34 | MDAAL…PLDPE → MGREPWPEDRDLGFPQLFCQ in isoform CRF2-gamma. 1 PublicationAdd BLAST | 34 | |
Alternative sequenceiVSP_053564 | 106 | Missing in isoform desQ. 1 Publication | 1 | |
Alternative sequenceiVSP_053565 | 366 – 411 | VRSAV…QTAAV → SWVSKEAQAAGPHGREKPEQ RW in isoform D. 1 PublicationAdd BLAST | 46 | |
Alternative sequenceiVSP_053566 | 366 – 411 | VRSAV…QTAAV → GLEPV in isoform E. 1 PublicationAdd BLAST | 46 | |
Alternative sequenceiVSP_053567 | 367 – 411 | Missing in isoform F. 1 PublicationAdd BLAST | 45 |
Sequence databases
Genome annotation databases
Ensembli | ENST00000341843; ENSP00000344304; ENSG00000106113 [Q13324-3] ENST00000348438; ENSP00000340943; ENSG00000106113 [Q13324-2] ENST00000471646; ENSP00000418722; ENSG00000106113 [Q13324-1] ENST00000506074; ENSP00000426498; ENSG00000106113 [Q13324-4] |
GeneIDi | 1395 |
KEGGi | hsa:1395 |
UCSCi | uc003tbn.4, human [Q13324-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
3N93 | X-ray | 2.50 | A/B | 3-104 | [»] | |
3N95 | X-ray | 2.72 | A/B/C/D | 3-104 | [»] | |
3N96 | X-ray | 2.75 | A/B/C/D | 3-104 | [»] | |
6PB1 | electron microscopy | 2.80 | P | 2-388 | [»] | |
SMRi | Q13324 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 107785, 3 interactors |
IntActi | Q13324, 2 interactors |
MINTi | Q13324 |
STRINGi | 9606.ENSP00000340943 |
Chemistry databases
BindingDBi | Q13324 |
ChEMBLi | CHEMBL4069 |
DrugCentrali | Q13324 |
GuidetoPHARMACOLOGYi | 213 |
Protein family/group databases
GPCRDBi | Search... |
PTM databases
GlyGeni | Q13324, 5 sites |
PhosphoSitePlusi | Q13324 |
Polymorphism and mutation databases
BioMutai | CRHR2 |
DMDMi | 6226847 |
Proteomic databases
PaxDbi | Q13324 |
PeptideAtlasi | Q13324 |
PRIDEi | Q13324 |
ProteomicsDBi | 30449 59312 [Q13324-1] 59313 [Q13324-2] 59314 [Q13324-3] |
Protocols and materials databases
Antibodypediai | 12618, 622 antibodies |
Genome annotation databases
Ensembli | ENST00000341843; ENSP00000344304; ENSG00000106113 [Q13324-3] ENST00000348438; ENSP00000340943; ENSG00000106113 [Q13324-2] ENST00000471646; ENSP00000418722; ENSG00000106113 [Q13324-1] ENST00000506074; ENSP00000426498; ENSG00000106113 [Q13324-4] |
GeneIDi | 1395 |
KEGGi | hsa:1395 |
UCSCi | uc003tbn.4, human [Q13324-1] |
Organism-specific databases
CTDi | 1395 |
DisGeNETi | 1395 |
EuPathDBi | HostDB:ENSG00000106113.18 |
GeneCardsi | CRHR2 |
HGNCi | HGNC:2358, CRHR2 |
HPAi | ENSG00000106113, Tissue enhanced (brain) |
MIMi | 602034, gene |
neXtProti | NX_Q13324 |
OpenTargetsi | ENSG00000106113 |
PharmGKBi | PA26875 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG4564, Eukaryota |
GeneTreei | ENSGT00940000156795 |
HOGENOMi | CLU_002753_4_1_1 |
InParanoidi | Q13324 |
OMAi | EFDVNCS |
OrthoDBi | 1163977at2759 |
PhylomeDBi | Q13324 |
TreeFami | TF315710 |
Enzyme and pathway databases
PathwayCommonsi | Q13324 |
Reactomei | R-HSA-373080, Class B/2 (Secretin family receptors) R-HSA-418555, G alpha (s) signalling events R-HSA-422085, Synthesis, secretion, and deacylation of Ghrelin R-HSA-9660821, ADORA2B mediated anti-inflammatory cytokines production |
Miscellaneous databases
BioGRID-ORCSi | 1395, 3 hits in 838 CRISPR screens |
ChiTaRSi | CRHR2, human |
EvolutionaryTracei | Q13324 |
GeneWikii | Corticotropin_releasing_hormone_receptor_2 |
GenomeRNAii | 1395 |
Pharosi | Q13324, Tbio |
PROi | PR:Q13324 |
RNActi | Q13324, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000106113, Expressed in frontal cortex and 107 other tissues |
ExpressionAtlasi | Q13324, baseline and differential |
Genevisiblei | Q13324, HS |
Family and domain databases
Gene3Di | 4.10.1240.10, 1 hit |
InterProi | View protein in InterPro IPR017981, GPCR_2-like IPR003053, GPCR_2_CRF2_rcpt IPR003051, GPCR_2_CRF_rcpt IPR036445, GPCR_2_extracell_dom_sf IPR001879, GPCR_2_extracellular_dom IPR000832, GPCR_2_secretin-like IPR017983, GPCR_2_secretin-like_CS |
Pfami | View protein in Pfam PF00002, 7tm_2, 1 hit PF02793, HRM, 1 hit |
PRINTSi | PR01279, CRFRECEPTOR PR01281, CRFRECEPTOR2 PR00249, GPCRSECRETIN |
SMARTi | View protein in SMART SM00008, HormR, 1 hit |
SUPFAMi | SSF111418, SSF111418, 1 hit |
PROSITEi | View protein in PROSITE PS00649, G_PROTEIN_RECEP_F2_1, 1 hit PS00650, G_PROTEIN_RECEP_F2_2, 1 hit PS50227, G_PROTEIN_RECEP_F2_3, 1 hit PS50261, G_PROTEIN_RECEP_F2_4, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CRFR2_HUMAN | |
Accessioni | Q13324Primary (citable) accession number: Q13324 Secondary accession number(s): B2R967 Q99431 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | May 30, 2000 | |
Last modified: | December 2, 2020 | |
This is version 171 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 7
Human chromosome 7: entries, gene names and cross-references to MIM - Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations - 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries