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Protein

Bcl-2-interacting killer

Gene

BIK

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Accelerates programmed cell death. Association to the apoptosis repressors Bcl-X(L), BHRF1, Bcl-2 or its adenovirus homolog E1B 19k protein suppresses this death-promoting activity. Does not interact with BAX.1 Publication

GO - Biological processi

  • apoptotic process Source: UniProtKB
  • male gonad development Source: GO_Central
  • positive regulation of protein homooligomerization Source: BHF-UCL
  • positive regulation of release of cytochrome c from mitochondria Source: BHF-UCL

Keywordsi

Biological processApoptosis

Enzyme and pathway databases

SIGNORiQ13323

Names & Taxonomyi

Protein namesi
Recommended name:
Bcl-2-interacting killer
Alternative name(s):
Apoptosis inducer NBK
BIP1
BP4
Gene namesi
Name:BIK
Synonyms:NBK
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

EuPathDBiHostDB:ENSG00000100290.2
HGNCiHGNC:1051 BIK
MIMi603392 gene
neXtProtiNX_Q13323

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei136 – 156HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane, Mitochondrion

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi153 – 154GG → FF: Inhibits RHBDL4/RHBDD1-induced cleavage. 1 Publication2

Organism-specific databases

DisGeNETi638
OpenTargetsiENSG00000100290
PharmGKBiPA25354

Polymorphism and mutation databases

BioMutaiBIK
DMDMi2493284

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001431001 – 160Bcl-2-interacting killerAdd BLAST160

Post-translational modificationi

Proteolytically cleaved by RHBDL4/RHBDD1. RHBDL4/RHBDD1-induced cleavage is a necessary step prior its degradation by the proteosome-dependent mechanism.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei153 – 154Cleavage; by RHBDL4/RHBDD1Curated2

Proteomic databases

PaxDbiQ13323
PeptideAtlasiQ13323
PRIDEiQ13323
ProteomicsDBi59311

PTM databases

iPTMnetiQ13323
PhosphoSitePlusiQ13323

Expressioni

Gene expression databases

BgeeiENSG00000100290 Expressed in 125 organ(s), highest expression level in nasal cavity epithelium
CleanExiHS_BIK
ExpressionAtlasiQ13323 baseline and differential
GenevisibleiQ13323 HS

Organism-specific databases

HPAiHPA051360

Interactioni

Subunit structurei

Interacts with RHBDL4/RHBDD1.1 Publication

Binary interactionsi

Protein-protein interaction databases

BioGridi107107, 13 interactors
ComplexPortaliCPX-309 BIK:BCL-w complex
DIPiDIP-928N
ELMiQ13323
IntActiQ13323, 96 interactors
MINTiQ13323
STRINGi9606.ENSP00000216115

Structurei

3D structure databases

ProteinModelPortaliQ13323
SMRiQ13323
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni137 – 158Leucine-zipperSequence analysisAdd BLAST22

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi57 – 71BH3Add BLAST15

Domaini

Intact BH3 motif is required by BIK, BID, BAK, BAD and BAX for their pro-apoptotic activity and for their interaction with anti-apoptotic members of the Bcl-2 family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410JHX0 Eukaryota
ENOG41116I0 LUCA
GeneTreeiENSGT00530000064453
HOGENOMiHOG000095229
HOVERGENiHBG001515
InParanoidiQ13323
KOiK18452
OMAiIYDQTED
OrthoDBiEOG091G0VGV
PhylomeDBiQ13323
TreeFamiTF338339

Family and domain databases

InterProiView protein in InterPro
IPR024579 Bcl2-int_killer
IPR020728 Bcl2_BH3_motif_CS
PANTHERiPTHR15018 PTHR15018, 1 hit
PfamiView protein in Pfam
PF12201 bcl-2I13, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD032623 PD032623, 1 hit
PROSITEiView protein in PROSITE
PS01259 BH3, 1 hit

Sequencei

Sequence statusi: Complete.

Q13323-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSEVRPLSRD ILMETLLYEQ LLEPPTMEVL GMTDSEEDLD PMEDFDSLEC
60 70 80 90 100
MEGSDALALR LACIGDEMDV SLRAPRLAQL SEVAMHSLGL AFIYDQTEDI
110 120 130 140 150
RDVLRSFMDG FTTLKENIMR FWRSPNPGSW VSCEQVLLAL LLLLALLLPL
160
LSGGLHLLLK
Length:160
Mass (Da):18,016
Last modified:November 1, 1997 - v2
Checksum:i89034F4443F5A136
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02917919E → K1 PublicationCorresponds to variant dbSNP:rs4988415Ensembl.1
Natural variantiVAR_04842026T → I. Corresponds to variant dbSNP:rs11090143Ensembl.1
Natural variantiVAR_029180148L → P. Corresponds to variant dbSNP:rs11574527Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U34584 mRNA Translation: AAC50413.1
U49730 mRNA Translation: AAC79124.1
X89986 mRNA Translation: CAA62013.1
AF174424
, AF174421, AF174422, AF174423 Genomic DNA Translation: AAF01156.1
CR456390 mRNA Translation: CAG30276.1
BT006728 mRNA Translation: AAP35374.1
AY245248 Genomic DNA Translation: AAO61089.1
CR541863 mRNA Translation: CAG46661.1
CR541883 mRNA Translation: CAG46681.1
AL022237 Genomic DNA Translation: CAA18260.2
CH471138 Genomic DNA Translation: EAW73282.1
BC001599 mRNA Translation: AAH01599.1
CCDSiCCDS14044.1
PIRiS58214
RefSeqiNP_001188.1, NM_001197.4
UniGeneiHs.475055

Genome annotation databases

EnsembliENST00000216115; ENSP00000216115; ENSG00000100290
GeneIDi638
KEGGihsa:638
UCSCiuc003bdk.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U34584 mRNA Translation: AAC50413.1
U49730 mRNA Translation: AAC79124.1
X89986 mRNA Translation: CAA62013.1
AF174424
, AF174421, AF174422, AF174423 Genomic DNA Translation: AAF01156.1
CR456390 mRNA Translation: CAG30276.1
BT006728 mRNA Translation: AAP35374.1
AY245248 Genomic DNA Translation: AAO61089.1
CR541863 mRNA Translation: CAG46661.1
CR541883 mRNA Translation: CAG46681.1
AL022237 Genomic DNA Translation: CAA18260.2
CH471138 Genomic DNA Translation: EAW73282.1
BC001599 mRNA Translation: AAH01599.1
CCDSiCCDS14044.1
PIRiS58214
RefSeqiNP_001188.1, NM_001197.4
UniGeneiHs.475055

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2IPEmodel-@1-160[»]
ProteinModelPortaliQ13323
SMRiQ13323
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107107, 13 interactors
ComplexPortaliCPX-309 BIK:BCL-w complex
DIPiDIP-928N
ELMiQ13323
IntActiQ13323, 96 interactors
MINTiQ13323
STRINGi9606.ENSP00000216115

PTM databases

iPTMnetiQ13323
PhosphoSitePlusiQ13323

Polymorphism and mutation databases

BioMutaiBIK
DMDMi2493284

Proteomic databases

PaxDbiQ13323
PeptideAtlasiQ13323
PRIDEiQ13323
ProteomicsDBi59311

Protocols and materials databases

DNASUi638
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000216115; ENSP00000216115; ENSG00000100290
GeneIDi638
KEGGihsa:638
UCSCiuc003bdk.3 human

Organism-specific databases

CTDi638
DisGeNETi638
EuPathDBiHostDB:ENSG00000100290.2
GeneCardsiBIK
HGNCiHGNC:1051 BIK
HPAiHPA051360
MIMi603392 gene
neXtProtiNX_Q13323
OpenTargetsiENSG00000100290
PharmGKBiPA25354
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410JHX0 Eukaryota
ENOG41116I0 LUCA
GeneTreeiENSGT00530000064453
HOGENOMiHOG000095229
HOVERGENiHBG001515
InParanoidiQ13323
KOiK18452
OMAiIYDQTED
OrthoDBiEOG091G0VGV
PhylomeDBiQ13323
TreeFamiTF338339

Enzyme and pathway databases

SIGNORiQ13323

Miscellaneous databases

GeneWikiiBcl-2-interacting_killer
GenomeRNAii638
PROiPR:Q13323
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000100290 Expressed in 125 organ(s), highest expression level in nasal cavity epithelium
CleanExiHS_BIK
ExpressionAtlasiQ13323 baseline and differential
GenevisibleiQ13323 HS

Family and domain databases

InterProiView protein in InterPro
IPR024579 Bcl2-int_killer
IPR020728 Bcl2_BH3_motif_CS
PANTHERiPTHR15018 PTHR15018, 1 hit
PfamiView protein in Pfam
PF12201 bcl-2I13, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD032623 PD032623, 1 hit
PROSITEiView protein in PROSITE
PS01259 BH3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiBIK_HUMAN
AccessioniPrimary (citable) accession number: Q13323
Secondary accession number(s): Q16582, Q6FH93
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: September 12, 2018
This is version 151 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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