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Entry version 163 (12 Aug 2020)
Sequence version 2 (01 Nov 1997)
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Protein

Bcl-2-interacting killer

Gene

BIK

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Accelerates programmed cell death. Association to the apoptosis repressors Bcl-X(L), BHRF1, Bcl-2 or its adenovirus homolog E1B 19k protein suppresses this death-promoting activity. Does not interact with BAX.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processApoptosis

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

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PathwayCommonsi
Q13323

SIGNOR Signaling Network Open Resource

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SIGNORi
Q13323

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Bcl-2-interacting killer
Alternative name(s):
Apoptosis inducer NBK
BIP1
BP4
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:BIK
Synonyms:NBK
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 22

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000100290.2

Human Gene Nomenclature Database

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HGNCi
HGNC:1051, BIK

Online Mendelian Inheritance in Man (OMIM)

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MIMi
603392, gene

neXtProt; the human protein knowledge platform

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neXtProti
NX_Q13323

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei136 – 156HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane, Mitochondrion

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi153 – 154GG → FF: Inhibits RHBDL4/RHBDD1-induced cleavage. 1 Publication2

Organism-specific databases

DisGeNET

More...
DisGeNETi
638

Open Targets

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OpenTargetsi
ENSG00000100290

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA25354

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

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Pharosi
Q13323, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
BIK

Domain mapping of disease mutations (DMDM)

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DMDMi
2493284

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001431001 – 160Bcl-2-interacting killerAdd BLAST160

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Proteolytically cleaved by RHBDL4/RHBDD1. RHBDL4/RHBDD1-induced cleavage is a necessary step prior its degradation by the proteosome-dependent mechanism.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei153 – 154Cleavage; by RHBDL4/RHBDD1Curated2

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q13323

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q13323

PeptideAtlas

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PeptideAtlasi
Q13323

PRoteomics IDEntifications database

More...
PRIDEi
Q13323

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
59311

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q13323

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q13323

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000100290, Expressed in nasal cavity epithelium and 148 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q13323, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q13323, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000100290, Tissue enhanced (blood, lymphoid tissue)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with RHBDL4/RHBDD1.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Q13323
With#Exp.IntAct
ADGRE2 [Q9UHX3]3EBI-700794,EBI-11277970
ADIPOQ [Q15848]3EBI-700794,EBI-10827839
AIG1 - isoform 2 [Q9NVV5-2]3EBI-700794,EBI-11957045
ALG8 [Q9BVK2]3EBI-700794,EBI-3921603
ANKRD46 - isoform 1 [Q86W74-2]3EBI-700794,EBI-12109402
APOD [P05090]3EBI-700794,EBI-715495
BCL2 [P10415]6EBI-700794,EBI-77694
BCL2A1 [Q16548]10EBI-700794,EBI-1003550
BCL2L1 [A0A0S2Z3D2]3EBI-700794,EBI-16431449
BCL2L1 [Q07817]12EBI-700794,EBI-78035
BCL2L1 - isoform Bcl-X(L) [Q07817-1]4EBI-700794,EBI-287195
BCL2L10 [Q9HD36]8EBI-700794,EBI-2126349
BCL2L2 [Q92843]22EBI-700794,EBI-707714
BMP10 [O95393]3EBI-700794,EBI-3922513
BNIP3 [Q12983]3EBI-700794,EBI-749464
BRICD5 - isoform 2 [Q6PL45-2]3EBI-700794,EBI-12244618
BTN2A2 [Q8WVV5]3EBI-700794,EBI-8648738
C16orf58 [Q96GQ5]3EBI-700794,EBI-8636004
C2CD2L [O14523]3EBI-700794,EBI-12822627
C4orf3 - isoform 2 [Q8WVX3-2]3EBI-700794,EBI-12003442
CACNG1 [Q06432]3EBI-700794,EBI-9686780
CD53 [P19397]3EBI-700794,EBI-6657396
CD72 [P21854]3EBI-700794,EBI-307924
CLDN19 - isoform 2 [Q8N6F1-2]3EBI-700794,EBI-12256978
CMTM5 - isoform 2 [Q96DZ9-2]3EBI-700794,EBI-11522780
CMTM7 [Q96FZ5]3EBI-700794,EBI-2807956
CNIH1 [O95406]3EBI-700794,EBI-12172273
CNIH3 [Q8TBE1]3EBI-700794,EBI-12208021
CTXN3 [Q4LDR2]3EBI-700794,EBI-12019274
CYB561 [P49447]3EBI-700794,EBI-8646596
CYB5B [O43169]3EBI-700794,EBI-1058710
ELOVL4 [Q9GZR5]3EBI-700794,EBI-18535450
ERGIC3 [Q9Y282]3EBI-700794,EBI-781551
EXOC3L2 [Q2M3D2]3EBI-700794,EBI-14890134
FAM209A [Q5JX71]3EBI-700794,EBI-18304435
FAM241B - isoform 2 [Q96D05-2]3EBI-700794,EBI-12118888
FAM3C [Q92520]3EBI-700794,EBI-2876774
FATE1 [Q969F0]8EBI-700794,EBI-743099
FCGR1A [P12314]3EBI-700794,EBI-2869867
GIMAP1 [Q8WWP7]3EBI-700794,EBI-11991950
GPX8 [Q8TED1]3EBI-700794,EBI-11721746
GRM2 [Q14416]3EBI-700794,EBI-10232876
INSIG2 [Q9Y5U4]3EBI-700794,EBI-8503746
KCNN4 [O15554]3EBI-700794,EBI-2924473
MARCHF5 [Q9NX47]3EBI-700794,EBI-2341610
MS4A13 [Q5J8X5]3EBI-700794,EBI-12070086
NAT8 [Q9UHE5]3EBI-700794,EBI-2863634
NRAC [Q8N912]3EBI-700794,EBI-12051377
NRM [Q8IXM6]3EBI-700794,EBI-10262547
PBX3 [Q96AL5]3EBI-700794,EBI-741171
PGAP2 - isoform 5 [Q9UHJ9-5]3EBI-700794,EBI-12092917
PGRMC1 [O00264]3EBI-700794,EBI-1045534
PLN [P26678]3EBI-700794,EBI-692836
PLP1 - isoform DM-20 [P60201-2]3EBI-700794,EBI-12188331
PLP2 [Q04941]3EBI-700794,EBI-608347
PLPP4 [Q5VZY2]3EBI-700794,EBI-10485931
REEP4 [Q9H6H4]3EBI-700794,EBI-7545592
SCAMP4 [Q969E2]3EBI-700794,EBI-4403649
SEC22A [Q96IW7]3EBI-700794,EBI-8652744
SELENOK [Q9Y6D0]3EBI-700794,EBI-9679163
SERP1 [Q9Y6X1]3EBI-700794,EBI-10329948
SERP2 [Q8N6R1]3EBI-700794,EBI-749270
SLC30A8 [Q8IWU4]3EBI-700794,EBI-10262251
SLC35A4 [Q96G79]3EBI-700794,EBI-12363689
SLC35E3 [Q7Z769]3EBI-700794,EBI-13389236
SLC37A4 [O43826]3EBI-700794,EBI-6269684
SLC39A7 [Q92504]3EBI-700794,EBI-1051105
SMIM1 [B2RUZ4]3EBI-700794,EBI-12188413
STRIT1 [P0DN84]3EBI-700794,EBI-12200293
STX8 [Q9UNK0]3EBI-700794,EBI-727240
TMBIM1 [Q969X1]3EBI-700794,EBI-2820569
TMEM107 [Q6UX40]3EBI-700794,EBI-12845616
TMEM11 [P17152]3EBI-700794,EBI-723946
TMEM120A [Q9BXJ8]3EBI-700794,EBI-727322
TMEM14B [Q9NUH8]3EBI-700794,EBI-8638294
TMEM14C [Q9P0S9]3EBI-700794,EBI-2339195
TMEM199 [Q8N511]3EBI-700794,EBI-10265825
TMEM222 [Q9H0R3]3EBI-700794,EBI-347385
TMEM229B [Q8NBD8]3EBI-700794,EBI-12195227
TMEM243 [Q9BU79]3EBI-700794,EBI-12887458
TMEM254 [Q8TBM7]3EBI-700794,EBI-11956809
TMEM60 [Q9H2L4]3EBI-700794,EBI-2852148
TMEM80 [Q96HE8]3EBI-700794,EBI-11742770
TMEM86B [Q8N661]3EBI-700794,EBI-2548832
TMEM97 [Q5BJF2]3EBI-700794,EBI-12111910
TSPO2 [Q5TGU0]3EBI-700794,EBI-12195249
TTMP [Q5BVD1]3EBI-700794,EBI-10243654
TUSC5 [A5PKU2]3EBI-700794,EBI-11988865
UBIAD1 [Q9Y5Z9]3EBI-700794,EBI-2819725
VAMP3 [Q15836]3EBI-700794,EBI-722343
VAMP5 [O95183]3EBI-700794,EBI-10191195
VKORC1 [Q9BQB6]3EBI-700794,EBI-6256462
ZFPL1 [O95159]3EBI-700794,EBI-718439

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
107107, 14 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-309, BIK:BCL-w complex

Database of interacting proteins

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DIPi
DIP-928N

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

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ELMi
Q13323

Protein interaction database and analysis system

More...
IntActi
Q13323, 103 interactors

Molecular INTeraction database

More...
MINTi
Q13323

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000216115

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q13323, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q13323

Database of comparative protein structure models

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ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni137 – 158Leucine-zipperSequence analysisAdd BLAST22

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi57 – 71BH3Add BLAST15

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Intact BH3 motif is required by BIK, BID, BAK, BAD and BAX for their pro-apoptotic activity and for their interaction with anti-apoptotic members of the Bcl-2 family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502TF5K, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00530000064453

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_139842_0_0_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q13323

KEGG Orthology (KO)

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KOi
K18452

Identification of Orthologs from Complete Genome Data

More...
OMAi
IYDQTED

Database of Orthologous Groups

More...
OrthoDBi
1487465at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q13323

TreeFam database of animal gene trees

More...
TreeFami
TF338339

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR024579, Bcl2-int_killer
IPR020728, Bcl2_BH3_motif_CS

The PANTHER Classification System

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PANTHERi
PTHR15018, PTHR15018, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12201, bcl-2I13, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01259, BH3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q13323-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSEVRPLSRD ILMETLLYEQ LLEPPTMEVL GMTDSEEDLD PMEDFDSLEC
60 70 80 90 100
MEGSDALALR LACIGDEMDV SLRAPRLAQL SEVAMHSLGL AFIYDQTEDI
110 120 130 140 150
RDVLRSFMDG FTTLKENIMR FWRSPNPGSW VSCEQVLLAL LLLLALLLPL
160
LSGGLHLLLK
Length:160
Mass (Da):18,016
Last modified:November 1, 1997 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i89034F4443F5A136
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_02917919E → K1 PublicationCorresponds to variant dbSNP:rs4988415Ensembl.1
Natural variantiVAR_04842026T → I. Corresponds to variant dbSNP:rs11090143Ensembl.1
Natural variantiVAR_029180148L → P. Corresponds to variant dbSNP:rs11574527Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U34584 mRNA Translation: AAC50413.1
U49730 mRNA Translation: AAC79124.1
X89986 mRNA Translation: CAA62013.1
AF174424 AF174423 Genomic DNA Translation: AAF01156.1
CR456390 mRNA Translation: CAG30276.1
BT006728 mRNA Translation: AAP35374.1
AY245248 Genomic DNA Translation: AAO61089.1
CR541863 mRNA Translation: CAG46661.1
CR541883 mRNA Translation: CAG46681.1
AL022237 Genomic DNA Translation: CAA18260.2
CH471138 Genomic DNA Translation: EAW73282.1
BC001599 mRNA Translation: AAH01599.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS14044.1

Protein sequence database of the Protein Information Resource

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PIRi
S58214

NCBI Reference Sequences

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RefSeqi
NP_001188.1, NM_001197.4

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000216115; ENSP00000216115; ENSG00000100290

Database of genes from NCBI RefSeq genomes

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GeneIDi
638

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:638

UCSC genome browser

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UCSCi
uc003bdk.3, human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U34584 mRNA Translation: AAC50413.1
U49730 mRNA Translation: AAC79124.1
X89986 mRNA Translation: CAA62013.1
AF174424 AF174423 Genomic DNA Translation: AAF01156.1
CR456390 mRNA Translation: CAG30276.1
BT006728 mRNA Translation: AAP35374.1
AY245248 Genomic DNA Translation: AAO61089.1
CR541863 mRNA Translation: CAG46661.1
CR541883 mRNA Translation: CAG46681.1
AL022237 Genomic DNA Translation: CAA18260.2
CH471138 Genomic DNA Translation: EAW73282.1
BC001599 mRNA Translation: AAH01599.1
CCDSiCCDS14044.1
PIRiS58214
RefSeqiNP_001188.1, NM_001197.4

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2IPEmodel-@1-160[»]
SMRiQ13323
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi107107, 14 interactors
ComplexPortaliCPX-309, BIK:BCL-w complex
DIPiDIP-928N
ELMiQ13323
IntActiQ13323, 103 interactors
MINTiQ13323
STRINGi9606.ENSP00000216115

PTM databases

iPTMnetiQ13323
PhosphoSitePlusiQ13323

Polymorphism and mutation databases

BioMutaiBIK
DMDMi2493284

Proteomic databases

MassIVEiQ13323
PaxDbiQ13323
PeptideAtlasiQ13323
PRIDEiQ13323
ProteomicsDBi59311

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
13376, 535 antibodies

The DNASU plasmid repository

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DNASUi
638

Genome annotation databases

EnsembliENST00000216115; ENSP00000216115; ENSG00000100290
GeneIDi638
KEGGihsa:638
UCSCiuc003bdk.3, human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
638
DisGeNETi638
EuPathDBiHostDB:ENSG00000100290.2

GeneCards: human genes, protein and diseases

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GeneCardsi
BIK
HGNCiHGNC:1051, BIK
HPAiENSG00000100290, Tissue enhanced (blood, lymphoid tissue)
MIMi603392, gene
neXtProtiNX_Q13323
OpenTargetsiENSG00000100290
PharmGKBiPA25354

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG502TF5K, Eukaryota
GeneTreeiENSGT00530000064453
HOGENOMiCLU_139842_0_0_1
InParanoidiQ13323
KOiK18452
OMAiIYDQTED
OrthoDBi1487465at2759
PhylomeDBiQ13323
TreeFamiTF338339

Enzyme and pathway databases

PathwayCommonsiQ13323
SIGNORiQ13323

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
638, 4 hits in 868 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
BIK, human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
Bcl-2-interacting_killer

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
638
PharosiQ13323, Tbio

Protein Ontology

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PROi
PR:Q13323
RNActiQ13323, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000100290, Expressed in nasal cavity epithelium and 148 other tissues
ExpressionAtlasiQ13323, baseline and differential
GenevisibleiQ13323, HS

Family and domain databases

InterProiView protein in InterPro
IPR024579, Bcl2-int_killer
IPR020728, Bcl2_BH3_motif_CS
PANTHERiPTHR15018, PTHR15018, 1 hit
PfamiView protein in Pfam
PF12201, bcl-2I13, 1 hit
PROSITEiView protein in PROSITE
PS01259, BH3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiBIK_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q13323
Secondary accession number(s): Q16582, Q6FH93
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: August 12, 2020
This is version 163 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
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