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UniProtKB - Q13323 (BIK_HUMAN)

Entry version 154 (13 Feb 2019)
Sequence version 2 (01 Nov 1997)
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Protein

Bcl-2-interacting killer

Gene

BIK

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Accelerates programmed cell death. Association to the apoptosis repressors Bcl-X(L), BHRF1, Bcl-2 or its adenovirus homolog E1B 19k protein suppresses this death-promoting activity. Does not interact with BAX.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

View the complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processApoptosis

Enzyme and pathway databases

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q13323

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Bcl-2-interacting killer
Alternative name(s):
Apoptosis inducer NBK
BIP1
BP4
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:BIK
Synonyms:NBK
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 22

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000100290.2

Human Gene Nomenclature Database

More...HGNCi		HGNC:1051 BIK

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		603392 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q13323

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei136 – 156HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane, Mitochondrion

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi153 – 154GG → FF: Inhibits RHBDL4/RHBDD1-induced cleavage. 1 Publication2

Organism-specific databases

DisGeNET

More...DisGeNETi		638

Open Targets

More...OpenTargetsi		ENSG00000100290

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA25354

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		BIK

Domain mapping of disease mutations (DMDM)

More...DMDMi		2493284

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001431001 – 160Bcl-2-interacting killerAdd BLAST160

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Proteolytically cleaved by RHBDL4/RHBDD1. RHBDL4/RHBDD1-induced cleavage is a necessary step prior its degradation by the proteosome-dependent mechanism.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei153 – 154Cleavage; by RHBDL4/RHBDD1Curated2

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q13323

PeptideAtlas

More...PeptideAtlasi		Q13323

PRoteomics IDEntifications database

More...PRIDEi		Q13323

ProteomicsDB human proteome resource

More...ProteomicsDBi		59311

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q13323

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q13323

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000100290 Expressed in 125 organ(s), highest expression level in nasal cavity epithelium

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q13323 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q13323 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		HPA051360

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with RHBDL4/RHBDD1.1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		107107, 14 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...ComplexPortali		CPX-309 BIK:BCL-w complex

Database of interacting proteins

More...DIPi		DIP-928N

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...ELMi		Q13323

Protein interaction database and analysis system

More...IntActi		Q13323, 96 interactors

Molecular INTeraction database

More...MINTi		Q13323

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000216115

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2IPEmodel-@1-160[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...ProteinModelPortali		Q13323

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q13323

Database of comparative protein structure models

More...ModBasei		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni137 – 158Leucine-zipperSequence analysisAdd BLAST22

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi57 – 71BH3Add BLAST15

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Intact BH3 motif is required by BIK, BID, BAK, BAD and BAX for their pro-apoptotic activity and for their interaction with anti-apoptotic members of the Bcl-2 family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG410JHX0 Eukaryota
ENOG41116I0 LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00530000064453

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		HOG000095229

The HOVERGEN Database of Homologous Vertebrate Genes

More...HOVERGENi		HBG001515

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q13323

KEGG Orthology (KO)

More...KOi		K18452

Identification of Orthologs from Complete Genome Data

More...OMAi		IYDQTED

Database of Orthologous Groups

More...OrthoDBi		1487465at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q13323

TreeFam database of animal gene trees

More...TreeFami		TF338339

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR024579 Bcl2-int_killer
IPR020728 Bcl2_BH3_motif_CS

The PANTHER Classification System

More...PANTHERi		PTHR15018 PTHR15018, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF12201 bcl-2I13, 1 hit

ProDom; a protein domain database

More...ProDomi		View protein in ProDom or Entries sharing at least one domain
PD032623 PD032623, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS01259 BH3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q13323-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSEVRPLSRD ILMETLLYEQ LLEPPTMEVL GMTDSEEDLD PMEDFDSLEC 
        60         70         80         90        100
MEGSDALALR LACIGDEMDV SLRAPRLAQL SEVAMHSLGL AFIYDQTEDI 
       110        120        130        140        150
RDVLRSFMDG FTTLKENIMR FWRSPNPGSW VSCEQVLLAL LLLLALLLPL 
       160
LSGGLHLLLK
Length:160
Mass (Da):18,016
Last modified:November 1, 1997 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i89034F4443F5A136
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_02917919E → K1 PublicationCorresponds to variant dbSNP:rs4988415Ensembl.1
Natural variantiVAR_04842026T → I. Corresponds to variant dbSNP:rs11090143Ensembl.1
Natural variantiVAR_029180148L → P. Corresponds to variant dbSNP:rs11574527Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
U34584 mRNA Translation: AAC50413.1
U49730 mRNA Translation: AAC79124.1
X89986 mRNA Translation: CAA62013.1
AF174424
, AF174421, AF174422, AF174423 Genomic DNA Translation: AAF01156.1
CR456390 mRNA Translation: CAG30276.1
BT006728 mRNA Translation: AAP35374.1
AY245248 Genomic DNA Translation: AAO61089.1
CR541863 mRNA Translation: CAG46661.1
CR541883 mRNA Translation: CAG46681.1
AL022237 Genomic DNA Translation: CAA18260.2
CH471138 Genomic DNA Translation: EAW73282.1
BC001599 mRNA Translation: AAH01599.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS14044.1

Protein sequence database of the Protein Information Resource

More...PIRi		S58214

NCBI Reference Sequences

More...RefSeqi		NP_001188.1, NM_001197.4

UniGene gene-oriented nucleotide sequence clusters

More...UniGenei		Hs.475055

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000216115; ENSP00000216115; ENSG00000100290

Database of genes from NCBI RefSeq genomes

More...GeneIDi		638

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:638

UCSC genome browser

More...UCSCi		uc003bdk.3 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U34584 mRNA Translation: AAC50413.1
U49730 mRNA Translation: AAC79124.1
X89986 mRNA Translation: CAA62013.1
AF174424
, AF174421, AF174422, AF174423 Genomic DNA Translation: AAF01156.1
CR456390 mRNA Translation: CAG30276.1
BT006728 mRNA Translation: AAP35374.1
AY245248 Genomic DNA Translation: AAO61089.1
CR541863 mRNA Translation: CAG46661.1
CR541883 mRNA Translation: CAG46681.1
AL022237 Genomic DNA Translation: CAA18260.2
CH471138 Genomic DNA Translation: EAW73282.1
BC001599 mRNA Translation: AAH01599.1
CCDSiCCDS14044.1
PIRiS58214
RefSeqiNP_001188.1, NM_001197.4
UniGeneiHs.475055

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2IPEmodel-@1-160[»]
ProteinModelPortaliQ13323
SMRiQ13323
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107107, 14 interactors
ComplexPortaliCPX-309 BIK:BCL-w complex
DIPiDIP-928N
ELMiQ13323
IntActiQ13323, 96 interactors
MINTiQ13323
STRINGi9606.ENSP00000216115

PTM databases

iPTMnetiQ13323
PhosphoSitePlusiQ13323

Polymorphism and mutation databases

BioMutaiBIK
DMDMi2493284

Proteomic databases

PaxDbiQ13323
PeptideAtlasiQ13323
PRIDEiQ13323
ProteomicsDBi59311

Protocols and materials databases

The DNASU plasmid repository

More...DNASUi		638
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000216115; ENSP00000216115; ENSG00000100290
GeneIDi638
KEGGihsa:638
UCSCiuc003bdk.3 human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		638
DisGeNETi638
EuPathDBiHostDB:ENSG00000100290.2

GeneCards: human genes, protein and diseases

More...GeneCardsi		BIK
HGNCiHGNC:1051 BIK
HPAiHPA051360
MIMi603392 gene
neXtProtiNX_Q13323
OpenTargetsiENSG00000100290
PharmGKBiPA25354

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG410JHX0 Eukaryota
ENOG41116I0 LUCA
GeneTreeiENSGT00530000064453
HOGENOMiHOG000095229
HOVERGENiHBG001515
InParanoidiQ13323
KOiK18452
OMAiIYDQTED
OrthoDBi1487465at2759
PhylomeDBiQ13323
TreeFamiTF338339

Enzyme and pathway databases

SIGNORiQ13323

Miscellaneous databases

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		Bcl-2-interacting_killer

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		638

Protein Ontology

More...PROi		PR:Q13323

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000100290 Expressed in 125 organ(s), highest expression level in nasal cavity epithelium
ExpressionAtlasiQ13323 baseline and differential
GenevisibleiQ13323 HS

Family and domain databases

InterProiView protein in InterPro
IPR024579 Bcl2-int_killer
IPR020728 Bcl2_BH3_motif_CS
PANTHERiPTHR15018 PTHR15018, 1 hit
PfamiView protein in Pfam
PF12201 bcl-2I13, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD032623 PD032623, 1 hit
PROSITEiView protein in PROSITE
PS01259 BH3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiBIK_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q13323
Secondary accession number(s): Q16582, Q6FH93
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: February 13, 2019
This is version 154 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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