BIK

Functionⁱ

Accelerates programmed cell death. Association to the apoptosis repressors Bcl-X(L), BHRF1, Bcl-2 or its adenovirus homolog E1B 19k protein suppresses this death-promoting activity. Does not interact with BAX.1 Publication

GO - Biological processⁱ

apoptotic process
Source: UniProtKB
Traceable author statementⁱ
- 10381623
male gonad development Source: GO_Central
positive regulation of protein homooligomerization
Source: BHF-UCL
Inferred from direct assayⁱ
- 21041309
positive regulation of release of cytochrome c from mitochondria
Source: BHF-UCL
Inferred from direct assayⁱ
- 21041309

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Apoptosis

Biological process

Apoptosis

Enzyme and pathway databases

SIGNORⁱ	Q13323

SIGNORⁱ

Q13323

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Bcl-2-interacting killer Alternative name(s): Apoptosis inducer NBK BIP1 BP4
Gene namesⁱ	Name:BIK Synonyms:NBK
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 22

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000100290.2
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:1051 BIK
MIMⁱ	603392 gene
neXtProtⁱ	NX_Q13323

Topology

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Transmembraneⁱ	136 – 156	HelicalSequence analysisAdd BLAST		21

Keywords - Cellular componentⁱ

Membrane, Mitochondrion

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	153 – 154	GG → FF: Inhibits RHBDL4/RHBDD1-induced cleavage. 1 Publication		2

Organism-specific databases

DisGeNET More...DisGeNETⁱ	638
Open Targets More...OpenTargetsⁱ	ENSG00000100290
PharmGKBⁱ	PA25354

Polymorphism and mutation databases

BioMutaⁱ	BIK
DMDMⁱ	2493284

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000143100	1 – 160	Bcl-2-interacting killerAdd BLAST		160

Post-translational modificationⁱ

Proteolytically cleaved by RHBDL4/RHBDD1. RHBDL4/RHBDD1-induced cleavage is a necessary step prior its degradation by the proteosome-dependent mechanism.1 Publication

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Siteⁱ	153 – 154	Cleavage; by RHBDL4/RHBDD1Curated		2

Proteomic databases

PaxDbⁱ	Q13323
PeptideAtlas More...PeptideAtlasⁱ	Q13323
PRIDEⁱ	Q13323
ProteomicsDBⁱ	59311

PTM databases

iPTMnetⁱ	Q13323
PhosphoSitePlusⁱ	Q13323

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000100290 Expressed in 125 organ(s), highest expression level in nasal cavity epithelium
CleanExⁱ	HS_BIK
ExpressionAtlasⁱ	Q13323 baseline and differential
Genevisibleⁱ	Q13323 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA051360

HPAⁱ

HPA051360

Interactionⁱ

Subunit structureⁱ

Interacts with RHBDL4/RHBDD1.1 Publication

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
BCL2	P10415	5	EBI-700794,EBI-77694
BCL2A1	Q16548	7	EBI-700794,EBI-1003550
BCL2L1	A0A0S2Z3D2	3	EBI-700794,EBI-16431449
BCL2L1	Q07817	12	EBI-700794,EBI-78035
BCL2L1	Q07817-1	4	EBI-700794,EBI-287195
BCL2L10	Q9HD36	2	EBI-700794,EBI-2126349
BCL2L2	Q92843	17	EBI-700794,EBI-707714
FATE1	Q969F0	6	EBI-700794,EBI-743099

Protein-protein interaction databases

BioGridⁱ	107107, 13 interactors
ComplexPortalⁱ	CPX-309 BIK:BCL-w complex
Database of interacting proteins More...DIPⁱ	DIP-928N
ELMⁱ	Q13323
IntActⁱ	Q13323, 96 interactors
Molecular INTeraction database More...MINTⁱ	Q13323
STRINGⁱ	9606.ENSP00000216115

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q13323
SMRⁱ	Q13323
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	137 – 158	Leucine-zipperSequence analysisAdd BLAST		22

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	57 – 71	BH3Add BLAST		15

Domainⁱ

Intact BH3 motif is required by BIK, BID, BAK, BAD and BAX for their pro-apoptotic activity and for their interaction with anti-apoptotic members of the Bcl-2 family.

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG410JHX0 Eukaryota ENOG41116I0 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000064453
HOGENOMⁱ	HOG000095229
HOVERGENⁱ	HBG001515
InParanoidⁱ	Q13323
KEGG Orthology (KO) More...KOⁱ	K18452
OMAⁱ	IYDQTED
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0VGV
PhylomeDBⁱ	Q13323
TreeFamⁱ	TF338339

Family and domain databases

InterProⁱ	View protein in InterPro IPR024579 Bcl2-int_killer IPR020728 Bcl2_BH3_motif_CS
PANTHERⁱ	PTHR15018 PTHR15018, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF12201 bcl-2I13, 1 hit
ProDomⁱ	View protein in ProDom or Entries sharing at least one domain PD032623 PD032623, 1 hit
PROSITEⁱ	View protein in PROSITE PS01259 BH3, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Q13323-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MSEVRPLSRD ILMETLLYEQ LLEPPTMEVL GMTDSEEDLD PMEDFDSLEC 
        60         70         80         90        100
MEGSDALALR LACIGDEMDV SLRAPRLAQL SEVAMHSLGL AFIYDQTEDI 
       110        120        130        140        150
RDVLRSFMDG FTTLKENIMR FWRSPNPGSW VSCEQVLLAL LLLLALLLPL 
       160
LSGGLHLLLK

Length:160

Mass (Da):18,016

Last modified:November 1, 1997 - v2

Checksum:ⁱ89034F4443F5A136

GO

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_029179	19	E → K1 PublicationCorresponds to variant dbSNP:rs4988415Ensembl.	1
Natural variantⁱVAR_048420	26	T → I. Corresponds to variant dbSNP:rs11090143Ensembl.	1
Natural variantⁱVAR_029180	148	L → P. Corresponds to variant dbSNP:rs11574527Ensembl.	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U34584 mRNA Translation: AAC50413.1 U49730 mRNA Translation: AAC79124.1 X89986 mRNA Translation: CAA62013.1 AF174424 , AF174421, AF174422, AF174423 Genomic DNA Translation: AAF01156.1 CR456390 mRNA Translation: CAG30276.1 BT006728 mRNA Translation: AAP35374.1 AY245248 Genomic DNA Translation: AAO61089.1 CR541863 mRNA Translation: CAG46661.1 CR541883 mRNA Translation: CAG46681.1 AL022237 Genomic DNA Translation: CAA18260.2 CH471138 Genomic DNA Translation: EAW73282.1 BC001599 mRNA Translation: AAH01599.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS14044.1
PIRⁱ	S58214
NCBI Reference Sequences More...RefSeqⁱ	NP_001188.1, NM_001197.4
UniGeneⁱ	Hs.475055

Genome annotation databases

Ensemblⁱ	ENST00000216115; ENSP00000216115; ENSG00000100290
GeneIDⁱ	638
KEGGⁱ	hsa:638
UCSC genome browser More...UCSCⁱ	uc003bdk.3 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q13323	BCL2-interacting killer (Apoptosis-inducing), isoform CRA_a		HUMAN		160	UniRef100_Q13323

Protein	Similar proteins		Species	Score	Length	Source
Q13323	BCL2-interacting killer (Apoptosis-inducing), isoform CRA_a		HUMAN		160	UniRef90_Q13323
Uncharacterized protein		PANPA		160
BCL2 interacting killer		PANTR		160
UPI0006C9C34A		PANPA		169
UPI000D09EE91		PANTR		169

Protein	Similar proteins		Species	Score	Length	Source
Q13323	BCL2-interacting killer (Apoptosis-inducing), isoform CRA_a		HUMAN		160	UniRef50_Q13323
BCL2 interacting killer		PANTR		160
Uncharacterized protein		PANPA		160
Uncharacterized protein		MACMU		160
Uncharacterized protein		MACFA		160
+24

Cross-referencesⁱ

Web resourcesⁱ

NIEHS-SNPs

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U34584 mRNA Translation: AAC50413.1 U49730 mRNA Translation: AAC79124.1 X89986 mRNA Translation: CAA62013.1 AF174424 , AF174421, AF174422, AF174423 Genomic DNA Translation: AAF01156.1 CR456390 mRNA Translation: CAG30276.1 BT006728 mRNA Translation: AAP35374.1 AY245248 Genomic DNA Translation: AAO61089.1 CR541863 mRNA Translation: CAG46661.1 CR541883 mRNA Translation: CAG46681.1 AL022237 Genomic DNA Translation: CAA18260.2 CH471138 Genomic DNA Translation: EAW73282.1 BC001599 mRNA Translation: AAH01599.1
CCDSⁱ	CCDS14044.1
PIRⁱ	S58214
RefSeqⁱ	NP_001188.1, NM_001197.4
UniGeneⁱ	Hs.475055

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2IPE	model	-	@	1-160	[»]
ProteinModelPortalⁱ	Q13323
SMRⁱ	Q13323
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	107107, 13 interactors
ComplexPortalⁱ	CPX-309 BIK:BCL-w complex
DIPⁱ	DIP-928N
ELMⁱ	Q13323
IntActⁱ	Q13323, 96 interactors
MINTⁱ	Q13323
STRINGⁱ	9606.ENSP00000216115

PTM databases

iPTMnetⁱ	Q13323
PhosphoSitePlusⁱ	Q13323

Polymorphism and mutation databases

BioMutaⁱ	BIK
DMDMⁱ	2493284

Proteomic databases

PaxDbⁱ	Q13323
PeptideAtlasⁱ	Q13323
PRIDEⁱ	Q13323
ProteomicsDBⁱ	59311

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	638
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000216115; ENSP00000216115; ENSG00000100290
GeneIDⁱ	638
KEGGⁱ	hsa:638
UCSCⁱ	uc003bdk.3 human

Organism-specific databases

CTDⁱ	638
DisGeNETⁱ	638
EuPathDBⁱ	HostDB:ENSG00000100290.2
GeneCardsⁱ	BIK
HGNCⁱ	HGNC:1051 BIK
HPAⁱ	HPA051360
MIMⁱ	603392 gene
neXtProtⁱ	NX_Q13323
OpenTargetsⁱ	ENSG00000100290
PharmGKBⁱ	PA25354
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410JHX0 Eukaryota ENOG41116I0 LUCA
GeneTreeⁱ	ENSGT00530000064453
HOGENOMⁱ	HOG000095229
HOVERGENⁱ	HBG001515
InParanoidⁱ	Q13323
KOⁱ	K18452
OMAⁱ	IYDQTED
OrthoDBⁱ	EOG091G0VGV
PhylomeDBⁱ	Q13323
TreeFamⁱ	TF338339

Enzyme and pathway databases

SIGNORⁱ	Q13323

SIGNORⁱ

Q13323

Miscellaneous databases

GeneWikiⁱ	Bcl-2-interacting_killer
GenomeRNAiⁱ	638
Protein Ontology More...PROⁱ	PR:Q13323
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000100290 Expressed in 125 organ(s), highest expression level in nasal cavity epithelium
CleanExⁱ	HS_BIK
ExpressionAtlasⁱ	Q13323 baseline and differential
Genevisibleⁱ	Q13323 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR024579 Bcl2-int_killer IPR020728 Bcl2_BH3_motif_CS
PANTHERⁱ	PTHR15018 PTHR15018, 1 hit
Pfamⁱ	View protein in Pfam PF12201 bcl-2I13, 1 hit
ProDomⁱ	View protein in ProDom or Entries sharing at least one domain PD032623 PD032623, 1 hit
PROSITEⁱ	View protein in PROSITE PS01259 BH3, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	BIK_HUMAN
Accessionⁱ	Q13323Primary (citable) accession number: Q13323 Secondary accession number(s): Q16582, Q6FH93
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
	Last sequence update:	November 1, 1997
	Last modified:	September 12, 2018
	This is version 151 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human chromosome 22
Human chromosome 22: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

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UniRef

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Supporting data

UniProtKB - Q13323 (BIK_HUMAN)

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Bcl-2-interacting killer

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Mitochondrion

Other locations

Mitochondrion

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Sites

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Motif

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

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Functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ