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UniProtKB - Q13323 (BIK_HUMAN)
Protein
Bcl-2-interacting killer
Gene
BIK
Organism
Homo sapiens (Human)
Status
Functioni
Accelerates programmed cell death. Association to the apoptosis repressors Bcl-X(L), BHRF1, Bcl-2 or its adenovirus homolog E1B 19k protein suppresses this death-promoting activity. Does not interact with BAX.
1 PublicationGO - Biological processi
- apoptotic mitochondrial changes Source: GO_Central
- apoptotic process Source: UniProtKB
- male gonad development Source: GO_Central
- positive regulation of protein-containing complex assembly Source: BHF-UCL
- positive regulation of release of cytochrome c from mitochondria Source: BHF-UCL
- regulation of apoptotic process Source: ComplexPortal
Keywordsi
Biological process | Apoptosis |
Enzyme and pathway databases
PathwayCommonsi | Q13323 |
SignaLinki | Q13323 |
SIGNORi | Q13323 |
Names & Taxonomyi
Protein namesi | Recommended name: Bcl-2-interacting killerAlternative name(s): Apoptosis inducer NBK BIP1 BP4 |
Gene namesi | Name:BIK Synonyms:NBK |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:1051, BIK |
MIMi | 603392, gene |
neXtProti | NX_Q13323 |
VEuPathDBi | HostDB:ENSG00000100290 |
Subcellular locationi
Mitochondrion
- Mitochondrion membrane By similarity; Single-pass membrane protein By similarity
Other locations
Note: Around the nuclear envelope, and in cytoplasmic membranes.
Mitochondrion
- mitochondrial membrane Source: UniProtKB-SubCell
Other locations
- Bcl-2 family protein complex Source: ComplexPortal
- endomembrane system Source: UniProtKB-SubCell
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 136 – 156 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
Membrane, MitochondrionPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 153 – 154 | GG → FF: Inhibits RHBDL4/RHBDD1-induced cleavage. 1 Publication | 2 |
Organism-specific databases
DisGeNETi | 638 |
OpenTargetsi | ENSG00000100290 |
PharmGKBi | PA25354 |
Miscellaneous databases
Pharosi | Q13323, Tbio |
Genetic variation databases
BioMutai | BIK |
DMDMi | 2493284 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000143100 | 1 – 160 | Bcl-2-interacting killerAdd BLAST | 160 |
Post-translational modificationi
Proteolytically cleaved by RHBDL4/RHBDD1. RHBDL4/RHBDD1-induced cleavage is a necessary step prior its degradation by the proteosome-dependent mechanism.1 Publication
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 153 – 154 | Cleavage; by RHBDL4/RHBDD1Curated | 2 |
Proteomic databases
MassIVEi | Q13323 |
PaxDbi | Q13323 |
PeptideAtlasi | Q13323 |
PRIDEi | Q13323 |
ProteomicsDBi | 59311 |
PTM databases
iPTMneti | Q13323 |
PhosphoSitePlusi | Q13323 |
Expressioni
Gene expression databases
Bgeei | ENSG00000100290, Expressed in nasal cavity epithelium and 149 other tissues |
ExpressionAtlasi | Q13323, baseline and differential |
Genevisiblei | Q13323, HS |
Organism-specific databases
HPAi | ENSG00000100290, Tissue enhanced (salivary) |
Interactioni
Subunit structurei
Interacts with RHBDL4/RHBDD1.
1 PublicationBinary interactionsi
Q13323
Protein-protein interaction databases
BioGRIDi | 107107, 99 interactors |
ComplexPortali | CPX-309, BIK:BCL-w complex |
DIPi | DIP-928N |
ELMi | Q13323 |
IntActi | Q13323, 103 interactors |
MINTi | Q13323 |
STRINGi | 9606.ENSP00000216115 |
Miscellaneous databases
RNActi | Q13323, protein |
Structurei
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 137 – 158 | Leucine-zipperSequence analysisAdd BLAST | 22 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 57 – 71 | BH3Add BLAST | 15 |
Domaini
Intact BH3 motif is required by BIK, BID, BAK, BAD and BAX for their pro-apoptotic activity and for their interaction with anti-apoptotic members of the Bcl-2 family.
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502TF5K, Eukaryota |
GeneTreei | ENSGT00530000064453 |
HOGENOMi | CLU_139842_0_0_1 |
InParanoidi | Q13323 |
OMAi | LECMEGS |
OrthoDBi | 1487465at2759 |
PhylomeDBi | Q13323 |
TreeFami | TF338339 |
Family and domain databases
InterProi | View protein in InterPro IPR024579, Bcl2-int_killer IPR020728, Bcl2_BH3_motif_CS |
PANTHERi | PTHR15018, PTHR15018, 1 hit |
Pfami | View protein in Pfam PF12201, bcl-2I13, 1 hit |
PROSITEi | View protein in PROSITE PS01259, BH3, 1 hit |
i Sequence
Sequence statusi: Complete.
Q13323-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSEVRPLSRD ILMETLLYEQ LLEPPTMEVL GMTDSEEDLD PMEDFDSLEC
60 70 80 90 100
MEGSDALALR LACIGDEMDV SLRAPRLAQL SEVAMHSLGL AFIYDQTEDI
110 120 130 140 150
RDVLRSFMDG FTTLKENIMR FWRSPNPGSW VSCEQVLLAL LLLLALLLPL
160
LSGGLHLLLK
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_029179 | 19 | E → K1 PublicationCorresponds to variant dbSNP:rs4988415Ensembl. | 1 | |
Natural variantiVAR_048420 | 26 | T → I. Corresponds to variant dbSNP:rs11090143Ensembl. | 1 | |
Natural variantiVAR_029180 | 148 | L → P. Corresponds to variant dbSNP:rs11574527Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U34584 mRNA Translation: AAC50413.1 U49730 mRNA Translation: AAC79124.1 X89986 mRNA Translation: CAA62013.1 AF174424 , AF174421, AF174422, AF174423 Genomic DNA Translation: AAF01156.1 CR456390 mRNA Translation: CAG30276.1 BT006728 mRNA Translation: AAP35374.1 AY245248 Genomic DNA Translation: AAO61089.1 CR541863 mRNA Translation: CAG46661.1 CR541883 mRNA Translation: CAG46681.1 AL022237 Genomic DNA Translation: CAA18260.2 CH471138 Genomic DNA Translation: EAW73282.1 BC001599 mRNA Translation: AAH01599.1 |
CCDSi | CCDS14044.1 |
PIRi | S58214 |
RefSeqi | NP_001188.1, NM_001197.4 |
Genome annotation databases
Ensembli | ENST00000216115; ENSP00000216115; ENSG00000100290 |
GeneIDi | 638 |
KEGGi | hsa:638 |
MANE-Selecti | ENST00000216115.3; ENSP00000216115.2; NM_001197.5; NP_001188.1 |
UCSCi | uc003bdk.3, human |
Similar proteinsi
Cross-referencesi
Web resourcesi
NIEHS-SNPs |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U34584 mRNA Translation: AAC50413.1 U49730 mRNA Translation: AAC79124.1 X89986 mRNA Translation: CAA62013.1 AF174424 , AF174421, AF174422, AF174423 Genomic DNA Translation: AAF01156.1 CR456390 mRNA Translation: CAG30276.1 BT006728 mRNA Translation: AAP35374.1 AY245248 Genomic DNA Translation: AAO61089.1 CR541863 mRNA Translation: CAG46661.1 CR541883 mRNA Translation: CAG46681.1 AL022237 Genomic DNA Translation: CAA18260.2 CH471138 Genomic DNA Translation: EAW73282.1 BC001599 mRNA Translation: AAH01599.1 |
CCDSi | CCDS14044.1 |
PIRi | S58214 |
RefSeqi | NP_001188.1, NM_001197.4 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 107107, 99 interactors |
ComplexPortali | CPX-309, BIK:BCL-w complex |
DIPi | DIP-928N |
ELMi | Q13323 |
IntActi | Q13323, 103 interactors |
MINTi | Q13323 |
STRINGi | 9606.ENSP00000216115 |
PTM databases
iPTMneti | Q13323 |
PhosphoSitePlusi | Q13323 |
Genetic variation databases
BioMutai | BIK |
DMDMi | 2493284 |
Proteomic databases
MassIVEi | Q13323 |
PaxDbi | Q13323 |
PeptideAtlasi | Q13323 |
PRIDEi | Q13323 |
ProteomicsDBi | 59311 |
Protocols and materials databases
Antibodypediai | 13376, 554 antibodies from 36 providers |
DNASUi | 638 |
Genome annotation databases
Ensembli | ENST00000216115; ENSP00000216115; ENSG00000100290 |
GeneIDi | 638 |
KEGGi | hsa:638 |
MANE-Selecti | ENST00000216115.3; ENSP00000216115.2; NM_001197.5; NP_001188.1 |
UCSCi | uc003bdk.3, human |
Organism-specific databases
CTDi | 638 |
DisGeNETi | 638 |
GeneCardsi | BIK |
HGNCi | HGNC:1051, BIK |
HPAi | ENSG00000100290, Tissue enhanced (salivary) |
MIMi | 603392, gene |
neXtProti | NX_Q13323 |
OpenTargetsi | ENSG00000100290 |
PharmGKBi | PA25354 |
VEuPathDBi | HostDB:ENSG00000100290 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502TF5K, Eukaryota |
GeneTreei | ENSGT00530000064453 |
HOGENOMi | CLU_139842_0_0_1 |
InParanoidi | Q13323 |
OMAi | LECMEGS |
OrthoDBi | 1487465at2759 |
PhylomeDBi | Q13323 |
TreeFami | TF338339 |
Enzyme and pathway databases
PathwayCommonsi | Q13323 |
SignaLinki | Q13323 |
SIGNORi | Q13323 |
Miscellaneous databases
BioGRID-ORCSi | 638, 10 hits in 1037 CRISPR screens |
ChiTaRSi | BIK, human |
GeneWikii | Bcl-2-interacting_killer |
GenomeRNAii | 638 |
Pharosi | Q13323, Tbio |
PROi | PR:Q13323 |
RNActi | Q13323, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000100290, Expressed in nasal cavity epithelium and 149 other tissues |
ExpressionAtlasi | Q13323, baseline and differential |
Genevisiblei | Q13323, HS |
Family and domain databases
InterProi | View protein in InterPro IPR024579, Bcl2-int_killer IPR020728, Bcl2_BH3_motif_CS |
PANTHERi | PTHR15018, PTHR15018, 1 hit |
Pfami | View protein in Pfam PF12201, bcl-2I13, 1 hit |
PROSITEi | View protein in PROSITE PS01259, BH3, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | BIK_HUMAN | |
Accessioni | Q13323Primary (citable) accession number: Q13323 Secondary accession number(s): Q16582, Q6FH93 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | November 1, 1997 | |
Last modified: | February 23, 2022 | |
This is version 170 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 22
Human chromosome 22: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot