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UniProtKB - Q13322 (GRB10_HUMAN)

Entry version 202 (31 Jul 2019)
Sequence version 2 (15 Jul 1999)
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Protein

Growth factor receptor-bound protein 10

Gene

GRB10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Adapter protein which modulates coupling of a number of cell surface receptor kinases with specific signaling pathways. Binds to, and suppress signals from, activated receptors tyrosine kinases, including the insulin (INSR) and insulin-like growth factor (IGF1R) receptors. The inhibitory effect can be achieved by 2 mechanisms: interference with the signaling pathway and increased receptor degradation. Delays and reduces AKT1 phosphorylation in response to insulin stimulation. Blocks association between INSR and IRS1 and IRS2 and prevents insulin-stimulated IRS1 and IRS2 tyrosine phosphorylation. Recruits NEDD4 to IGF1R, leading to IGF1R ubiquitination, increased internalization and degradation by both the proteasomal and lysosomal pathways. May play a role in mediating insulin-stimulated ubiquitination of INSR, leading to proteasomal degradation. Negatively regulates Wnt signaling by interacting with LRP6 intracellular portion and interfering with the binding of AXIN1 to LRP6. Positive regulator of the KDR/VEGFR-2 signaling pathway. May inhibit NEDD4-mediated degradation of KDR/VEGFR-2.4 Publications

Miscellaneous

The GRB10 locus is imprinted. During embryonic development, the expression in the brain and spinal cord is from the paternal allele, while in placental villous trophoblasts and skeletal muscle, it is from the maternal one. Expression is biallelic in most other tissues. Paternal expression in the brain is maintained throughout adulthood. Imprinting often is isoform-specific.
GRB10 is unlikely to be responsible for Silver-Russell syndrome (SRS).

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Phosphorylation by mTORC1 stabilizes and activates GRB10 constituting a feedback pathway by which mTORC1 inhibits INSR-dependent signaling.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • SH3/SH2 adaptor activity Source: GO_Central
  • identical protein binding Source: IntAct
  • insulin receptor binding Source: BHF-UCL
Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-1433557 Signaling by SCF-KIT
R-HSA-74713 IRS activation
R-HSA-74749 Signal attenuation
R-HSA-74751 Insulin receptor signalling cascade
R-HSA-8853659 RET signaling

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q13322

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q13322

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Growth factor receptor-bound protein 10
Alternative name(s):
GRB10 adapter protein
Insulin receptor-binding protein Grb-IR
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:GRB10
Synonyms:GRBIR, KIAA0207
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:4564 GRB10

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		601523 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q13322

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi104S → G: No effect on phosphorylation. 1 Publication1
Mutagenesisi134S → A: No effect on YWHAE-binding. 1 Publication1
Mutagenesisi136P → A: No effect on NEDD4-binding; when associated with A-139 and A-141. 1 Publication1
Mutagenesisi139P → A: No effect on NEDD4-binding; when associated with A-136 and A-141. 1 Publication1
Mutagenesisi141P → S: No effect on NEDD4-binding; when associated with A-136 and A-139. 1 Publication1
Mutagenesisi150S → I: Loss of phosphorylation. 1 Publication1
Mutagenesisi300K → A: 2-fold loss of inositide-binding. 1 Publication1
Mutagenesisi305K → A: 5-fold loss of inositide-binding. 1 Publication1
Mutagenesisi308K → A: 5-fold loss of inositide-binding. 1 Publication1
Mutagenesisi355N → G: 5-fold loss of inositide-binding. 1 Publication1
Mutagenesisi418S → A: No net loss of phosphorylation, this may be due to a compensatory phosphorylation of T-422 in vitro. 1 Publication1
Mutagenesisi428S → A: Impairs YWHAE-binding. 1 Publication1
Mutagenesisi476S → A: Loss of phosphorylation. 1 Publication1
Mutagenesisi520R → K: No effect on NEDD4-binding. No effect on the disruption of the interaction between INSR and IRS1 and IRS2. 2 Publications1

Organism-specific databases

DisGeNET

More...DisGeNETi		2887

Open Targets

More...OpenTargetsi		ENSG00000106070

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA28960

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL3621028

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		GRB10

Domain mapping of disease mutations (DMDM)

More...DMDMi		6166186

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001503461 – 594Growth factor receptor-bound protein 10Add BLAST594

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei67Phosphotyrosine; by TEC1 Publication1
Modified residuei104PhosphoserineCombined sources1
Modified residuei150Phosphoserine; by MTOR, MAPK1 and MAPK32 Publications1
Modified residuei418Phosphoserine; by MAPK1 and MAPK3; in vitroCombined sources1 Publication1
Modified residuei428Phosphoserine; by MTOR and PKB/AKT12 Publications1
Modified residuei431PhosphoserineBy similarity1
Modified residuei476Phosphoserine; by MTOR, MAPK1 and MAPK32 Publications1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated on serine residues upon EGF, FGF and PDGF stimulation (By similarity). Phosphorylated at Tyr-67 by TEC.By similarity4 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

The CPTAC Assay portal

More...CPTACi		CPTAC-1247

Encyclopedia of Proteome Dynamics

More...EPDi		Q13322

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q13322

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q13322

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q13322

PeptideAtlas

More...PeptideAtlasi		Q13322

PRoteomics IDEntifications database

More...PRIDEi		Q13322

ProteomicsDB human proteome resource

More...ProteomicsDBi		59307 [Q13322-1]
59308 [Q13322-2]
59309 [Q13322-3]
59310 [Q13322-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q13322

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q13322

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed in fetal and adult tissues, including fetal and postnatal liver, lung, kidney, skeletal muscle, heart, spleen, skin and brain.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000106070 Expressed in 233 organ(s), highest expression level in visceral pleura

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q13322 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q13322 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		CAB019423
HPA027502
HPA031818

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with ligand-activated tyrosine kinase receptors, including FGFR1, INSR, IGF1R, MET and PDGFRB in a phosphotyrosine-dependent manner through the SH2 domain (By similarity). Poorly binds to the EGFR (By similarity). Directly interacts with MAP3K14/NIK and is recruited to the EGFR-ERBB2 complex.

Interacts with GIGYF1/PERQ1 and GIGYF2/TNRC15 (By similarity). When unphosphorylated, interacts with AKT1 and when phosphorylated with YWHAE/14-3-3 epsilon.

Interacts with NEDD4.

Interacts with LRP6, thus interfering with the binding of AXIN1 to LRP6 (By similarity). Binds to activated NRAS.

By similarity5 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		109144, 43 interactors

Database of interacting proteins

More...DIPi		DIP-31657N

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...ELMi		Q13322

Protein interaction database and analysis system

More...IntActi		Q13322, 32 interactors

Molecular INTeraction database

More...MINTi		Q13322

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000381793

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		Q13322

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1594
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q13322

Database of comparative protein structure models

More...ModBasei		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		Q13322

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini166 – 250Ras-associatingPROSITE-ProRule annotationAdd BLAST85
Domaini290 – 399PHPROSITE-ProRule annotationAdd BLAST110
Domaini493 – 574SH2PROSITE-ProRule annotationAdd BLAST82

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The PH domain binds relatively non-specifically to several phosphoinositides, including PI5P, PI(4,5)P2, PI(3,4)P2 and PI(3,4,5)P3, with modest affinities.

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the GRB7/10/14 family.Curated

Keywords - Domaini

SH2 domain

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3751 Eukaryota
ENOG410XXC8 LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00940000155909

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q13322

KEGG Orthology (KO)

More...KOi		K20064

Identification of Orthologs from Complete Genome Data

More...OMAi		CSMQSET

Database of Orthologous Groups

More...OrthoDBi		497681at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q13322

TreeFam database of animal gene trees

More...TreeFami		TF317511

Family and domain databases

Conserved Domains Database

More...CDDi		cd01259 PH_APBB1IP, 1 hit
cd10415 SH2_Grb10, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.30.29.30, 1 hit
3.30.505.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR015042 BPS-dom
IPR039664 GRB/APBB1IP
IPR035036 Grb10
IPR035037 Grb10_SH2
IPR011993 PH-like_dom_sf
IPR039665 PH_APBB1IP
IPR001849 PH_domain
IPR000159 RA_dom
IPR000980 SH2
IPR036860 SH2_dom_sf
IPR029071 Ubiquitin-like_domsf

The PANTHER Classification System

More...PANTHERi		PTHR11243 PTHR11243, 1 hit
PTHR11243:SF4 PTHR11243:SF4, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF08947 BPS, 1 hit
PF00169 PH, 1 hit
PF00788 RA, 1 hit
PF00017 SH2, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00401 SH2DOMAIN

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00233 PH, 1 hit
SM00314 RA, 1 hit
SM00252 SH2, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF54236 SSF54236, 1 hit
SSF55550 SSF55550, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50003 PH_DOMAIN, 1 hit
PS50200 RA, 1 hit
PS50001 SH2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Note: Additional isoforms seem to exist, many of which involve splicing of 5' non-coding exons.

This entry has 4 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 3 (identifier: Q13322-1) [UniParc]FASTAAdd to basket
Also known as: Zeta

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MALAGCPDSF LHHPYYQDKV EQTPRSQQDP AGPGLPAQSD RLANHQEDDV 
        60         70         80         90        100
DLEALVNDMN ASLESLYSAC SMQSDTVPLL QNGQHARSQP RASGPPRSIQ 
       110        120        130        140        150
PQVSPRQRVQ RSQPVHILAV RRLQEEDQQF RTSSLPAIPN PFPELCGPGS 
       160        170        180        190        200
PPVLTPGSLP PSQAAAKQDV KVFSEDGTSK VVEILADMTA RDLCQLLVYK 
       210        220        230        240        250
SHCVDDNSWT LVEHHPHLGL ERCLEDHELV VQVESTMASE SKFLFRKNYA 
       260        270        280        290        300
KYEFFKNPMN FFPEQMVTWC QQSNGSQTQL LQNFLNSSSC PEIQGFLHVK 
       310        320        330        340        350
ELGKKSWKKL YVCLRRSGLY CSTKGTSKEP RHLQLLADLE DSNIFSLIAG 
       360        370        380        390        400
RKQYNAPTDH GLCIKPNKVR NETKELRLLC AEDEQTRTCW MTAFRLLKYG 
       410        420        430        440        450
MLLYQNYRIP QQRKALLSPF STPVRSVSEN SLVAMDFSGQ TGRVIENPAE 
       460        470        480        490        500
AQSAALEEGH AWRKRSTRMN ILGSQSPLHP STLSTVIHRT QHWFHGRISR 
       510        520        530        540        550
EESHRIIKQQ GLVDGLFLLR DSQSNPKAFV LTLCHHQKIK NFQILPCEDD 
       560        570        580        590 
GQTFFSLDDG NTKFSDLIQL VDFYQLNKGV LPCKLKHHCI RVAL
Length:594
Mass (Da):67,231
Last modified:July 15, 1999 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i53A5F885E17C6C6B
GO
Isoform 1 (identifier: Q13322-2) [UniParc]FASTAAdd to basket
Also known as: Beta

The sequence of this isoform differs from the canonical sequence as follows:
     283-328: Missing.

Show »
Length:548
Mass (Da):62,026
Checksum:iFCAA0792DBEB8AC3
GO
Isoform 2 (identifier: Q13322-3) [UniParc]FASTAAdd to basket
Also known as: Gamma, Beta, SV-1

The sequence of this isoform differs from the canonical sequence as follows:
     1-58: Missing.

Show »
Length:536
Mass (Da):60,848
Checksum:i626377A169AE6530
GO
Isoform 4 (identifier: Q13322-4) [UniParc]FASTAAdd to basket
Also known as: Epsilon

The sequence of this isoform differs from the canonical sequence as follows:
     1-17: MALAGCPDSFLHHPYYQ → MQAAGPLFRSK

Note: No experimental confirmation available.
Show »
Length:588
Mass (Da):66,487
Checksum:iB5EE8FA86A240D21
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2R8YCL1A0A2R8YCL1_HUMAN
Growth factor receptor-bound protei...
GRB10
632Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C3B9H7C3B9_HUMAN
Growth factor receptor-bound protei...
GRB10
108Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JTW6C9JTW6_HUMAN
Growth factor receptor-bound protei...
GRB10
55Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8Y6Q4A0A2R8Y6Q4_HUMAN
Growth factor receptor-bound protei...
GRB10
94Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA13198 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti152P → A in BAA13198 (PubMed:9039502).Curated1
Sequence conflicti400G → E in AAB08431 (PubMed:9006901).Curated1
Sequence conflicti428S → F in BAF82200 (PubMed:14702039).Curated1
Sequence conflicti498I → F in AAB08431 (PubMed:9006901).Curated1
Sequence conflicti541N → I in AAC50671 (PubMed:8798417).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_05311236P → L. Corresponds to variant dbSNP:rs35647889Ensembl.1
Natural variantiVAR_06286495P → S1 PublicationCorresponds to variant dbSNP:rs80244589Ensembl.1
Natural variantiVAR_053113558D → H. Corresponds to variant dbSNP:rs11768472Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0018421 – 58Missing in isoform 2. 4 PublicationsAdd BLAST58
Alternative sequenceiVSP_0387841 – 17MALAG…HPYYQ → MQAAGPLFRSK in isoform 4. 1 PublicationAdd BLAST17
Alternative sequenceiVSP_001843283 – 328Missing in isoform 1. 2 PublicationsAdd BLAST46

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
U34355 mRNA Translation: AAA88819.1
U66065 mRNA Translation: AAC50671.1
U69276 mRNA Translation: AAB08431.1
AF001534 mRNA Translation: AAB81134.1
AF000017 mRNA Translation: AAC19748.1
AB000731 mRNA Translation: BAF76353.1
AJ271366 mRNA Translation: CAB96542.1
D86962 mRNA Translation: BAA13198.2 Different initiation.
AK289511 mRNA Translation: BAF82200.1
AF073378
, AF073363, AF073364, AF073365, AF073366, AF073367, AF073368, AF073369, AF073370, AF073371, AF073372, AF073373, AF073374, AF073375, AF073376, AF073377 Genomic DNA Translation: AAC83655.1
AF073378
, AF073363, AF073364, AF073365, AF073366, AF073367, AF073368, AF073369, AF073371, AF073372, AF073373, AF073374, AF073375, AF073376, AF073377 Genomic DNA Translation: AAC83654.1
AC005153 Genomic DNA No translation available.
CH236955 Genomic DNA Translation: EAL23897.1
CH471128 Genomic DNA Translation: EAW60964.1
CH471128 Genomic DNA Translation: EAW60965.1
CH471128 Genomic DNA Translation: EAW60967.1
BC024285 mRNA Translation: AAH24285.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS43582.1 [Q13322-1]
CCDS43583.1 [Q13322-3]
CCDS47586.1 [Q13322-2]
CCDS87503.1 [Q13322-4]

Protein sequence database of the Protein Information Resource

More...PIRi		I39175

NCBI Reference Sequences

More...RefSeqi		NP_001001549.1, NM_001001549.2 [Q13322-2]
NP_001001550.1, NM_001001550.2 [Q13322-3]
NP_001001555.1, NM_001001555.2 [Q13322-3]
NP_005302.3, NM_005311.4
XP_011513606.1, XM_011515304.1
XP_011513614.1, XM_011515312.2
XP_011513618.1, XM_011515316.1 [Q13322-3]
XP_016867534.1, XM_017012045.1 [Q13322-3]
XP_016867535.1, XM_017012046.1 [Q13322-1]
XP_016867552.1, XM_017012063.1 [Q13322-3]
XP_016867553.1, XM_017012064.1 [Q13322-3]
XP_016867554.1, XM_017012065.1 [Q13322-3]
XP_016867555.1, XM_017012066.1
XP_016867556.1, XM_017012067.1 [Q13322-3]
XP_016867557.1, XM_017012068.1 [Q13322-3]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000335866; ENSP00000338543; ENSG00000106070 [Q13322-3]
ENST00000357271; ENSP00000349818; ENSG00000106070 [Q13322-2]
ENST00000398810; ENSP00000381790; ENSG00000106070 [Q13322-3]
ENST00000398812; ENSP00000381793; ENSG00000106070 [Q13322-1]
ENST00000401949; ENSP00000385770; ENSG00000106070 [Q13322-1]
ENST00000402497; ENSP00000385748; ENSG00000106070 [Q13322-3]
ENST00000402578; ENSP00000385189; ENSG00000106070 [Q13322-3]
ENST00000403097; ENSP00000385544; ENSG00000106070 [Q13322-3]
ENST00000406641; ENSP00000385366; ENSG00000106070 [Q13322-3]
ENST00000407526; ENSP00000385046; ENSG00000106070 [Q13322-3]
ENST00000643299; ENSP00000496245; ENSG00000106070 [Q13322-3]
ENST00000645075; ENSP00000495341; ENSG00000106070 [Q13322-4]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		2887

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:2887

UCSC genome browser

More...UCSCi		uc003tph.4 human [Q13322-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U34355 mRNA Translation: AAA88819.1
U66065 mRNA Translation: AAC50671.1
U69276 mRNA Translation: AAB08431.1
AF001534 mRNA Translation: AAB81134.1
AF000017 mRNA Translation: AAC19748.1
AB000731 mRNA Translation: BAF76353.1
AJ271366 mRNA Translation: CAB96542.1
D86962 mRNA Translation: BAA13198.2 Different initiation.
AK289511 mRNA Translation: BAF82200.1
AF073378
, AF073363, AF073364, AF073365, AF073366, AF073367, AF073368, AF073369, AF073370, AF073371, AF073372, AF073373, AF073374, AF073375, AF073376, AF073377 Genomic DNA Translation: AAC83655.1
AF073378
, AF073363, AF073364, AF073365, AF073366, AF073367, AF073368, AF073369, AF073371, AF073372, AF073373, AF073374, AF073375, AF073376, AF073377 Genomic DNA Translation: AAC83654.1
AC005153 Genomic DNA No translation available.
CH236955 Genomic DNA Translation: EAL23897.1
CH471128 Genomic DNA Translation: EAW60964.1
CH471128 Genomic DNA Translation: EAW60965.1
CH471128 Genomic DNA Translation: EAW60967.1
BC024285 mRNA Translation: AAH24285.1
CCDSiCCDS43582.1 [Q13322-1]
CCDS43583.1 [Q13322-3]
CCDS47586.1 [Q13322-2]
CCDS87503.1 [Q13322-4]
PIRiI39175
RefSeqiNP_001001549.1, NM_001001549.2 [Q13322-2]
NP_001001550.1, NM_001001550.2 [Q13322-3]
NP_001001555.1, NM_001001555.2 [Q13322-3]
NP_005302.3, NM_005311.4
XP_011513606.1, XM_011515304.1
XP_011513614.1, XM_011515312.2
XP_011513618.1, XM_011515316.1 [Q13322-3]
XP_016867534.1, XM_017012045.1 [Q13322-3]
XP_016867535.1, XM_017012046.1 [Q13322-1]
XP_016867552.1, XM_017012063.1 [Q13322-3]
XP_016867553.1, XM_017012064.1 [Q13322-3]
XP_016867554.1, XM_017012065.1 [Q13322-3]
XP_016867555.1, XM_017012066.1
XP_016867556.1, XM_017012067.1 [Q13322-3]
XP_016867557.1, XM_017012068.1 [Q13322-3]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1NRVX-ray1.65A/B487-591[»]
3HK0X-ray2.60A/B164-415[»]
SMRiQ13322
ModBaseiSearch...

Protein-protein interaction databases

BioGridi109144, 43 interactors
DIPiDIP-31657N
ELMiQ13322
IntActiQ13322, 32 interactors
MINTiQ13322
STRINGi9606.ENSP00000381793

Chemistry databases

BindingDBiQ13322
ChEMBLiCHEMBL3621028

PTM databases

iPTMnetiQ13322
PhosphoSitePlusiQ13322

Polymorphism and mutation databases

BioMutaiGRB10
DMDMi6166186

Proteomic databases

CPTACiCPTAC-1247
EPDiQ13322
jPOSTiQ13322
MaxQBiQ13322
PaxDbiQ13322
PeptideAtlasiQ13322
PRIDEiQ13322
ProteomicsDBi59307 [Q13322-1]
59308 [Q13322-2]
59309 [Q13322-3]
59310 [Q13322-4]

Protocols and materials databases

The DNASU plasmid repository

More...DNASUi		2887
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000335866; ENSP00000338543; ENSG00000106070 [Q13322-3]
ENST00000357271; ENSP00000349818; ENSG00000106070 [Q13322-2]
ENST00000398810; ENSP00000381790; ENSG00000106070 [Q13322-3]
ENST00000398812; ENSP00000381793; ENSG00000106070 [Q13322-1]
ENST00000401949; ENSP00000385770; ENSG00000106070 [Q13322-1]
ENST00000402497; ENSP00000385748; ENSG00000106070 [Q13322-3]
ENST00000402578; ENSP00000385189; ENSG00000106070 [Q13322-3]
ENST00000403097; ENSP00000385544; ENSG00000106070 [Q13322-3]
ENST00000406641; ENSP00000385366; ENSG00000106070 [Q13322-3]
ENST00000407526; ENSP00000385046; ENSG00000106070 [Q13322-3]
ENST00000643299; ENSP00000496245; ENSG00000106070 [Q13322-3]
ENST00000645075; ENSP00000495341; ENSG00000106070 [Q13322-4]
GeneIDi2887
KEGGihsa:2887
UCSCiuc003tph.4 human [Q13322-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		2887
DisGeNETi2887

GeneCards: human genes, protein and diseases

More...GeneCardsi		GRB10
HGNCiHGNC:4564 GRB10
HPAiCAB019423
HPA027502
HPA031818
MIMi601523 gene
neXtProtiNX_Q13322
OpenTargetsiENSG00000106070
PharmGKBiPA28960

Human Unidentified Gene-Encoded large proteins database

More...HUGEi		Search...

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG3751 Eukaryota
ENOG410XXC8 LUCA
GeneTreeiENSGT00940000155909
InParanoidiQ13322
KOiK20064
OMAiCSMQSET
OrthoDBi497681at2759
PhylomeDBiQ13322
TreeFamiTF317511

Enzyme and pathway databases

ReactomeiR-HSA-1433557 Signaling by SCF-KIT
R-HSA-74713 IRS activation
R-HSA-74749 Signal attenuation
R-HSA-74751 Insulin receptor signalling cascade
R-HSA-8853659 RET signaling
SignaLinkiQ13322
SIGNORiQ13322

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		GRB10 human
EvolutionaryTraceiQ13322

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		GRB10

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		2887

Protein Ontology

More...PROi		PR:Q13322

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000106070 Expressed in 233 organ(s), highest expression level in visceral pleura
ExpressionAtlasiQ13322 baseline and differential
GenevisibleiQ13322 HS

Family and domain databases

CDDicd01259 PH_APBB1IP, 1 hit
cd10415 SH2_Grb10, 1 hit
Gene3Di2.30.29.30, 1 hit
3.30.505.10, 1 hit
InterProiView protein in InterPro
IPR015042 BPS-dom
IPR039664 GRB/APBB1IP
IPR035036 Grb10
IPR035037 Grb10_SH2
IPR011993 PH-like_dom_sf
IPR039665 PH_APBB1IP
IPR001849 PH_domain
IPR000159 RA_dom
IPR000980 SH2
IPR036860 SH2_dom_sf
IPR029071 Ubiquitin-like_domsf
PANTHERiPTHR11243 PTHR11243, 1 hit
PTHR11243:SF4 PTHR11243:SF4, 1 hit
PfamiView protein in Pfam
PF08947 BPS, 1 hit
PF00169 PH, 1 hit
PF00788 RA, 1 hit
PF00017 SH2, 1 hit
PRINTSiPR00401 SH2DOMAIN
SMARTiView protein in SMART
SM00233 PH, 1 hit
SM00314 RA, 1 hit
SM00252 SH2, 1 hit
SUPFAMiSSF54236 SSF54236, 1 hit
SSF55550 SSF55550, 1 hit
PROSITEiView protein in PROSITE
PS50003 PH_DOMAIN, 1 hit
PS50200 RA, 1 hit
PS50001 SH2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGRB10_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q13322
Secondary accession number(s): A4D258
, A7VJ95, A8K0E6, D3DVM9, O00427, O00701, O75222, Q92606, Q92907, Q92948
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: July 15, 1999
Last modified: July 31, 2019
This is version 202 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
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