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Protein

Cyclin-dependent kinase 5 activator 2

Gene

CDK5R2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Activator of CDK5/TPKII.

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandLipid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-dependent kinase 5 activator 2
Short name:
CDK5 activator 2
Alternative name(s):
Cyclin-dependent kinase 5 regulatory subunit 2
p39
p39I
Gene namesi
Name:CDK5R2
Synonyms:NCK5AI
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000171450.5
HGNCiHGNC:1776 CDK5R2
MIMi603764 gene
neXtProtiNX_Q13319

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi2G → A: Absent from the cell periphery. 1 Publication1

Organism-specific databases

DisGeNETi8941
OpenTargetsiENSG00000171450
PharmGKBiPA26312

Polymorphism and mutation databases

BioMutaiCDK5R2

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000004801? – 367Cyclin-dependent kinase 5 activator 2
Initiator methionineiRemoved1 Publication
PropeptideiPRO_00000048002 – ?Sequence analysis

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi2N-myristoyl glycine1 Publication1
Modified residuei84PhosphothreonineBy similarity1

Post-translational modificationi

Myristoylated. The Gly-2-Ala mutant is absent of the cell periphery, suggesting that a proper myristoylation signal is essential for the proper distribution of CDK5R2 (p39).1 Publication

Keywords - PTMi

Lipoprotein, Myristate, Phosphoprotein

Proteomic databases

PaxDbiQ13319
PeptideAtlasiQ13319
PRIDEiQ13319
ProteomicsDBi59306

PTM databases

iPTMnetiQ13319
PhosphoSitePlusiQ13319

Miscellaneous databases

PMAP-CutDBiQ13319

Expressioni

Tissue specificityi

Brain and neuron specific.

Gene expression databases

BgeeiENSG00000171450 Expressed in 100 organ(s), highest expression level in anterior cingulate cortex
CleanExiHS_CDK5R2
GenevisibleiQ13319 HS

Interactioni

Subunit structurei

Heterodimer of a catalytic subunit and a regulatory subunit.

GO - Molecular functioni

Protein-protein interaction databases

BioGridi114453, 1 interactor
ComplexPortaliCPX-3141 Cyclin-dependent protein kinase 5 holoenzyme complex, p39 variant
MINTiQ13319
STRINGi9606.ENSP00000304250

Structurei

3D structure databases

ProteinModelPortaliQ13319
SMRiQ13319
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi75 – 78Poly-Lys4
Compositional biasi130 – 133Poly-Ala4
Compositional biasi155 – 163Poly-Pro9

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3932 Eukaryota
ENOG410YFUI LUCA
GeneTreeiENSGT00390000008812
HOGENOMiHOG000063677
HOVERGENiHBG050853
InParanoidiQ13319
KOiK19929
OMAiGTKHWTM
OrthoDBiEOG091G0OB3
PhylomeDBiQ13319
TreeFamiTF101036

Family and domain databases

InterProiView protein in InterPro
IPR004944 CDK5_activator
IPR036915 Cyclin-like_sf
PfamiView protein in Pfam
PF03261 CDK5_activator, 1 hit
PIRSFiPIRSF009324 Cdk5_activator, 1 hit
SUPFAMiSSF47954 SSF47954, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q13319-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGTVLSLSPA SSAKGRRPGG LPEEKKKAPP AGDEALGGYG APPVGKGGKG
60 70 80 90 100
ESRLKRPSVL ISALTWKRLV AASAKKKKGS KKVTPKPAST GPDPLVQQRN
110 120 130 140 150
RENLLRKGRD PPDGGGTAKP LAVPVPTVPA AAATCEPPSG GSAAAQPPGS
160 170 180 190 200
GGGKPPPPPP PAPQVAPPVP GGSPRRVIVQ ASTGELLRCL GDFVCRRCYR
210 220 230 240 250
LKELSPGELV GWFRGVDRSL LLQGWQDQAF ITPANLVFVY LLCRESLRGD
260 270 280 290 300
ELASAAELQA AFLTCLYLAY SYMGNEISYP LKPFLVEPDK ERFWQRCLRL
310 320 330 340 350
IQRLSPQMLR LNADPHFFTQ VFQDLKNEGE AAASGGGPPS GGAPAASSAA
360
RDSCAAGTKH WTMNLDR
Length:367
Mass (Da):38,705
Last modified:November 1, 1997 - v1
Checksum:iD8CBB7C8E0AA8200
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U34051 mRNA Translation: AAC50278.1
DQ307839 Genomic DNA Translation: ABB96255.1
AC097468 Genomic DNA Translation: AAX88916.1
CCDSiCCDS2427.1
PIRiI39172
RefSeqiNP_003927.1, NM_003936.4
UniGeneiHs.158460

Genome annotation databases

EnsembliENST00000302625; ENSP00000304250; ENSG00000171450
GeneIDi8941
KEGGihsa:8941
UCSCiuc002vjf.5 human

Similar proteinsi

Cross-referencesi

Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U34051 mRNA Translation: AAC50278.1
DQ307839 Genomic DNA Translation: ABB96255.1
AC097468 Genomic DNA Translation: AAX88916.1
CCDSiCCDS2427.1
PIRiI39172
RefSeqiNP_003927.1, NM_003936.4
UniGeneiHs.158460

3D structure databases

ProteinModelPortaliQ13319
SMRiQ13319
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114453, 1 interactor
ComplexPortaliCPX-3141 Cyclin-dependent protein kinase 5 holoenzyme complex, p39 variant
MINTiQ13319
STRINGi9606.ENSP00000304250

PTM databases

iPTMnetiQ13319
PhosphoSitePlusiQ13319

Polymorphism and mutation databases

BioMutaiCDK5R2

Proteomic databases

PaxDbiQ13319
PeptideAtlasiQ13319
PRIDEiQ13319
ProteomicsDBi59306

Protocols and materials databases

DNASUi8941
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000302625; ENSP00000304250; ENSG00000171450
GeneIDi8941
KEGGihsa:8941
UCSCiuc002vjf.5 human

Organism-specific databases

CTDi8941
DisGeNETi8941
EuPathDBiHostDB:ENSG00000171450.5
GeneCardsiCDK5R2
H-InvDBiHIX0161641
HGNCiHGNC:1776 CDK5R2
MIMi603764 gene
neXtProtiNX_Q13319
OpenTargetsiENSG00000171450
PharmGKBiPA26312
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3932 Eukaryota
ENOG410YFUI LUCA
GeneTreeiENSGT00390000008812
HOGENOMiHOG000063677
HOVERGENiHBG050853
InParanoidiQ13319
KOiK19929
OMAiGTKHWTM
OrthoDBiEOG091G0OB3
PhylomeDBiQ13319
TreeFamiTF101036

Miscellaneous databases

ChiTaRSiCDK5R2 human
GeneWikiiCDK5R2
GenomeRNAii8941
PMAP-CutDBiQ13319
PROiPR:Q13319
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000171450 Expressed in 100 organ(s), highest expression level in anterior cingulate cortex
CleanExiHS_CDK5R2
GenevisibleiQ13319 HS

Family and domain databases

InterProiView protein in InterPro
IPR004944 CDK5_activator
IPR036915 Cyclin-like_sf
PfamiView protein in Pfam
PF03261 CDK5_activator, 1 hit
PIRSFiPIRSF009324 Cdk5_activator, 1 hit
SUPFAMiSSF47954 SSF47954, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCD5R2_HUMAN
AccessioniPrimary (citable) accession number: Q13319
Secondary accession number(s): Q4ZFW6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: November 7, 2018
This is version 145 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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