DMP1

Functionⁱ

May have a dual function during osteoblast differentiation. In the nucleus of undifferentiated osteoblasts, unphosphorylated form acts as a transcriptional component for activation of osteoblast-specific genes like osteocalcin. During the osteoblast to osteocyte transition phase it is phosphorylated and exported into the extracellular matrix, where it regulates nucleation of hydroxyapatite.1 Publication

GO - Molecular functionⁱ

calcium ion binding
Source: ProtInc
Traceable author statementⁱ
- 8509401
extracellular matrix binding Source: Ensembl
integrin binding
Source: ProtInc
Traceable author statementⁱ
- 8509401

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

biomineral tissue development Source: UniProtKB-KW
cellular protein metabolic process Source: Reactome
extracellular matrix organization Source: Reactome
ossification
Source: ProtInc
Traceable author statementⁱ
- 8509401
positive regulation of cell-substrate adhesion Source: Ensembl
post-translational protein modification Source: Reactome
regulation of enamel mineralization Source: Ensembl

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Biomineralization

Biological process

Biomineralization

Enzyme and pathway databases

Reactomeⁱ	R-HSA-3000178 ECM proteoglycans R-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-8957275 Post-translational protein phosphorylation
SignaLinkⁱ	Q13316

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Dentin matrix acidic phosphoprotein 1 Short name: DMP-1 Short name: Dentin matrix protein 1
Gene namesⁱ	Name:DMP1
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 4

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000152592.13
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:2932 DMP1
MIMⁱ	600980 gene
neXtProtⁱ	NX_Q13316

Keywords - Cellular componentⁱ

Cytoplasm, Extracellular matrix, Nucleus, Secreted

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Hypophosphatemic rickets, autosomal recessive, 1 (ARHR1)2 Publications

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA hereditary form of hypophosphatemic rickets, a disorder of proximal renal tubule function that causes phosphate loss, hypophosphatemia and skeletal deformities, including rickets and osteomalacia unresponsive to vitamin D. Symptoms are bone pain, fractures and growth abnormalities.

Organism-specific databases

DisGeNET More...DisGeNETⁱ	1758
MalaCards human disease database More...MalaCardsⁱ	DMP1
MIMⁱ	241520 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000152592
Orphanetⁱ	289176 Autosomal recessive hypophosphatemic rickets
PharmGKBⁱ	PA27379

Polymorphism and mutation databases

BioMutaⁱ	DMP1
DMDMⁱ	7673998

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 16	Sequence analysisAdd BLAST		16
ChainⁱPRO_0000021110	17 – 513	Dentin matrix acidic phosphoprotein 1Add BLAST		497

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	25	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	285	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	324	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	345	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	351	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	413	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	426	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	467	N-linked (GlcNAc...) asparagineSequence analysis	1

Post-translational modificationⁱ

Phosphorylated in the cytosol and extracellular matrix and unphosphorylated in the nucleus. Phosphorylation is necessary for nucleocytoplasmic transport and may be catalyzed by a nuclear isoform of CK2 and can be augmented by calcium. Phosphorylated (in vitro) by FAM20C in the extracellular medium at sites within the S-x-E/pS motif.2 Publications

Keywords - PTMⁱ

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbⁱ	Q13316
PeptideAtlas More...PeptideAtlasⁱ	Q13316
PRIDEⁱ	Q13316
ProteomicsDBⁱ	59304 59305 [Q13316-2]

PTM databases

iPTMnetⁱ	Q13316
PhosphoSitePlusⁱ	Q13316

Expressionⁱ

Tissue specificityⁱ

Expressed in tooth particularly in odontoblast, ameloblast and cementoblast.

Gene expression databases

Bgeeⁱ	ENSG00000152592 Expressed in 80 organ(s), highest expression level in tibia
CleanExⁱ	HS_DMP1
Genevisibleⁱ	Q13316 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA037465

HPAⁱ

HPA037465

Interactionⁱ

Subunit structureⁱ

Interacts with importin alpha.1 Publication

GO - Molecular functionⁱ

integrin binding
Source: ProtInc
Traceable author statementⁱ
- 8509401

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

IntActⁱ	Q13316, 1 interactor
STRINGⁱ	9606.ENSP00000340935

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q13316
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	364 – 366	Cell attachment siteSequence analysis		3

Keywords - Domainⁱ

Signal

Phylogenomic databases

eggNOGⁱ	KOG1181 Eukaryota ENOG4111M3T LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00730000111375
HOGENOMⁱ	HOG000220909
HOVERGENⁱ	HBG073257
InParanoidⁱ	Q13316
OMAⁱ	PIGDQDD
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0U5E
PhylomeDBⁱ	Q13316
TreeFamⁱ	TF337029

Family and domain databases

InterProⁱ	View protein in InterPro IPR009889 DMP1
PANTHERⁱ	PTHR23400 PTHR23400, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF07263 DMP1, 1 hit

Sequences (2)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

Isoform 1 (identifier: Q13316-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKISILLMFL WGLSCALPVT RYQNNESEDS EEWKGHLAQA PTPPLESSES 
        60         70         80         90        100
SEGSKVSSEE QANEDPSDST QSEEGLGSDD HQYIYRLAGG FSRSTGKGGD 
       110        120        130        140        150
DKDDDEDDSG DDTFGDDDSG PGPKDRQEGG NSRLGSDEDS DDTIQASEES 
       160        170        180        190        200
APQGQDSAQD TTSESRELDN EDRVDSKPEG GDSTQESESE EHWVGGGSDG 
       210        220        230        240        250
ESSHGDGSEL DDEGMQSDDP ESIRSERGNS RMNSAGMKSK ESGENSEQAN 
       260        270        280        290        300
TQDSGGSQLL EHPSRKIFRK SRISEEDDRS ELDDNNTMEE VKSDSTENSN 
       310        320        330        340        350
SRDTGLSQPR RDSKGDSQED SKENLSQEES QNVDGPSSES SQEANLSSQE 
       360        370        380        390        400
NSSESQEEVV SESRGDNPDP TTSYVEDQED SDSSEEDSSH TLSHSKSESR 
       410        420        430        440        450
EEQADSESSE SLNFSEESPE SPEDENSSSQ EGLQSHSSSA ESQSEESHSE 
       460        470        480        490        500
EDDSDSQDSS RSKEDSNSTE SKSSSEEDGQ LKNIEIESRK LTVDAYHNKP 
       510 
IGDQDDNDCQ DGY

Length:513

Mass (Da):55,782

Last modified:January 1, 1998 - v2

Checksum:ⁱ2C1FDE319A5D106F

GO

Isoform 2 (identifier: Q13316-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
46-61: Missing.

« Hide

        10         20         30         40         50
MKISILLMFL WGLSCALPVT RYQNNESEDS EEWKGHLAQA PTPPLANEDP 
        60         70         80         90        100
SDSTQSEEGL GSDDHQYIYR LAGGFSRSTG KGGDDKDDDE DDSGDDTFGD 
       110        120        130        140        150
DDSGPGPKDR QEGGNSRLGS DEDSDDTIQA SEESAPQGQD SAQDTTSESR 
       160        170        180        190        200
ELDNEDRVDS KPEGGDSTQE SESEEHWVGG GSDGESSHGD GSELDDEGMQ 
       210        220        230        240        250
SDDPESIRSE RGNSRMNSAG MKSKESGENS EQANTQDSGG SQLLEHPSRK 
       260        270        280        290        300
IFRKSRISEE DDRSELDDNN TMEEVKSDST ENSNSRDTGL SQPRRDSKGD 
       310        320        330        340        350
SQEDSKENLS QEESQNVDGP SSESSQEANL SSQENSSESQ EEVVSESRGD 
       360        370        380        390        400
NPDPTTSYVE DQEDSDSSEE DSSHTLSHSK SESREEQADS ESSESLNFSE 
       410        420        430        440        450
ESPESPEDEN SSSQEGLQSH SSSAESQSEE SHSEEDDSDS QDSSRSKEDS 
       460        470        480        490 
NSTESKSSSE EDGQLKNIEI ESRKLTVDAY HNKPIGDQDD NDCQDGY

Show »

Length:497

Mass (Da):54,115

Checksum:ⁱ6E146232B6365507

GO

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_030750	69	S → C2 PublicationsCorresponds to variant dbSNP:rs10019009EnsemblClinVar.	1
Natural variantⁱVAR_030751	117	D → N in one individual with tumoral calcinosis. 1 PublicationCorresponds to variant dbSNP:rs140719182Ensembl.	1
Natural variantⁱVAR_030752	272	R → H1 PublicationCorresponds to variant dbSNP:rs145237146EnsemblClinVar.	1
Natural variantⁱVAR_033848	463	K → R. Corresponds to variant dbSNP:rs34661425EnsemblClinVar.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_004191	46 – 61	Missing in isoform 2. 1 PublicationAdd BLAST		16

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U89012 mRNA Translation: AAC51332.1 U34037 Genomic DNA Translation: AAA97602.1 CH471057 Genomic DNA Translation: EAX05996.1 BC130581 mRNA Translation: AAI30582.1 BC132865 mRNA Translation: AAI32866.1 U65378 mRNA Translation: AAB87728.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS3623.1 [Q13316-1] CCDS43249.1 [Q13316-2]
NCBI Reference Sequences More...RefSeqⁱ	NP_001073380.1, NM_001079911.2 [Q13316-2] NP_004398.1, NM_004407.3 [Q13316-1]
UniGeneⁱ	Hs.652366

Genome annotation databases

Ensemblⁱ	ENST00000282479; ENSP00000282479; ENSG00000152592 [Q13316-2] ENST00000339673; ENSP00000340935; ENSG00000152592 [Q13316-1]
GeneIDⁱ	1758
KEGGⁱ	hsa:1758
UCSC genome browser More...UCSCⁱ	uc003hqv.4 human [Q13316-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q13316	DMP1 isoform 2		PANTR		513	UniRef90_Q13316
Dentin matrix acidic phosphoprotein 1		GORGO		513
Dentin matrix acidic phosphoprotein 1		Cebus capucinus imitator		513
Dentin matrix acidic phosphoprotein 1		PONAB		513
Dentin matrix acidic phosphoprotein 1		PANPA		513
+41

Protein	Similar proteins		Species	Score	Length	Source
Q13316	Dentin matrix acidic phosphoprotein 1		BOVIN		510	UniRef50_Q13316
Dentin matrix acidic phosphoprotein 1		MOUSE		503
Dentin matrix acidic phosphoprotein 1		RAT		489
DMP1 isoform 2		PANTR		513
Dentin matrix acidic phosphoprotein 1		GORGO		513
+236

Entry informationⁱ

Entry nameⁱ	DMP1_HUMAN
Accessionⁱ	Q13316Primary (citable) accession number: Q13316 Secondary accession number(s): A1L4L3, O43265
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
	Last sequence update:	January 1, 1998
	Last modified:	September 12, 2018
	This is version 146 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q13316 (DMP1_HUMAN)

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Dentin matrix acidic phosphoprotein 1

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted

Nucleus

Other locations

Endoplasmic reticulum

Extracellular region or secreted

Nucleus

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Motif

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ