UniProtKB - Q13316 (DMP1_HUMAN)
Protein
Dentin matrix acidic phosphoprotein 1
Gene
DMP1
Organism
Homo sapiens (Human)
Status
Functioni
May have a dual function during osteoblast differentiation. In the nucleus of undifferentiated osteoblasts, unphosphorylated form acts as a transcriptional component for activation of osteoblast-specific genes like osteocalcin. During the osteoblast to osteocyte transition phase it is phosphorylated and exported into the extracellular matrix, where it regulates nucleation of hydroxyapatite.1 Publication
GO - Molecular functioni
- calcium ion binding Source: ProtInc
- extracellular matrix binding Source: Ensembl
- integrin binding Source: ProtInc
GO - Biological processi
- biomineral tissue development Source: UniProtKB-KW
- cellular protein metabolic process Source: Reactome
- extracellular matrix organization Source: Reactome
- ossification Source: ProtInc
- positive regulation of cell-substrate adhesion Source: Ensembl
- post-translational protein modification Source: Reactome
- regulation of enamel mineralization Source: Ensembl
Keywordsi
Biological process | Biomineralization |
Enzyme and pathway databases
PathwayCommonsi | Q13316 |
Reactomei | R-HSA-3000178, ECM proteoglycans R-HSA-381426, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-8957275, Post-translational protein phosphorylation |
SignaLinki | Q13316 |
Names & Taxonomyi
Protein namesi | Recommended name: Dentin matrix acidic phosphoprotein 1Short name: DMP-1 Short name: Dentin matrix protein 1 |
Gene namesi | Name:DMP1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000152592.13 |
HGNCi | HGNC:2932, DMP1 |
MIMi | 600980, gene |
neXtProti | NX_Q13316 |
Subcellular locationi
Nucleus
- Nucleus 1 Publication
Extracellular region or secreted
- extracellular matrix 1 Publication
Other locations
- Cytoplasm 1 Publication
Note: In proliferating preosteoblasts it is nuclear, during early maturation stage is cytoplasmic and in mature osteoblast localizes in the mineralized matrix. Export from the nucleus of differentiating osteoblast is triggered by the release of calcium from intracellular stores followed by a massive influx of this pool of calcium into the nucleus.
Endoplasmic reticulum
- endoplasmic reticulum lumen Source: Reactome
Extracellular region or secreted
- extracellular matrix Source: ProtInc
- extracellular region Source: Reactome
Nucleus
- nucleus Source: UniProtKB-SubCell
Keywords - Cellular componenti
Cytoplasm, Extracellular matrix, Nucleus, SecretedPathology & Biotechi
Involvement in diseasei
Hypophosphatemic rickets, autosomal recessive, 1 (ARHR1)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA hereditary form of hypophosphatemic rickets, a disorder of proximal renal tubule function that causes phosphate loss, hypophosphatemia and skeletal deformities, including rickets and osteomalacia unresponsive to vitamin D. Symptoms are bone pain, fractures and growth abnormalities.
Related information in OMIMOrganism-specific databases
DisGeNETi | 1758 |
MalaCardsi | DMP1 |
MIMi | 241520, phenotype |
OpenTargetsi | ENSG00000152592 |
Orphaneti | 289176, Autosomal recessive hypophosphatemic rickets |
PharmGKBi | PA27379 |
Miscellaneous databases
Pharosi | Q13316, Tbio |
Polymorphism and mutation databases
BioMutai | DMP1 |
DMDMi | 7673998 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 16 | Sequence analysisAdd BLAST | 16 | |
ChainiPRO_0000021110 | 17 – 513 | Dentin matrix acidic phosphoprotein 1Add BLAST | 497 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 25 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 285 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 324 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 345 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 351 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 413 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 426 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 467 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Post-translational modificationi
Phosphorylated in the cytosol and extracellular matrix and unphosphorylated in the nucleus. Phosphorylation is necessary for nucleocytoplasmic transport and may be catalyzed by a nuclear isoform of CK2 and can be augmented by calcium. Phosphorylated (in vitro) by FAM20C in the extracellular medium at sites within the S-x-E/pS motif.2 Publications
Keywords - PTMi
Glycoprotein, PhosphoproteinProteomic databases
MassIVEi | Q13316 |
PaxDbi | Q13316 |
PeptideAtlasi | Q13316 |
PRIDEi | Q13316 |
ProteomicsDBi | 59304 [Q13316-1] 59305 [Q13316-2] |
PTM databases
GlyGeni | Q13316, 8 sites |
iPTMneti | Q13316 |
PhosphoSitePlusi | Q13316 |
Expressioni
Tissue specificityi
Expressed in tooth particularly in odontoblast, ameloblast and cementoblast.
Gene expression databases
Bgeei | ENSG00000152592, Expressed in tibia and 85 other tissues |
Genevisiblei | Q13316, HS |
Organism-specific databases
HPAi | ENSG00000152592, Tissue enhanced (pituitary gland, testis) |
Interactioni
Subunit structurei
Interacts with importin alpha.
1 PublicationGO - Molecular functioni
- integrin binding Source: ProtInc
Protein-protein interaction databases
BioGRIDi | 108098, 2 interactors |
IntActi | Q13316, 1 interactor |
STRINGi | 9606.ENSP00000340935 |
Miscellaneous databases
RNActi | Q13316, protein |
Family & Domainsi
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 364 – 366 | Cell attachment siteSequence analysis | 3 |
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | KOG1181, Eukaryota |
GeneTreei | ENSGT00730000111375 |
HOGENOMi | CLU_040174_0_0_1 |
InParanoidi | Q13316 |
OMAi | ARYQNTE |
OrthoDBi | 1235561at2759 |
PhylomeDBi | Q13316 |
TreeFami | TF337029 |
Family and domain databases
InterProi | View protein in InterPro IPR009889, DMP1 |
PANTHERi | PTHR23400, PTHR23400, 1 hit |
Pfami | View protein in Pfam PF07263, DMP1, 1 hit |
s (2)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketIsoform 1 (identifier: Q13316-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MKISILLMFL WGLSCALPVT RYQNNESEDS EEWKGHLAQA PTPPLESSES
60 70 80 90 100
SEGSKVSSEE QANEDPSDST QSEEGLGSDD HQYIYRLAGG FSRSTGKGGD
110 120 130 140 150
DKDDDEDDSG DDTFGDDDSG PGPKDRQEGG NSRLGSDEDS DDTIQASEES
160 170 180 190 200
APQGQDSAQD TTSESRELDN EDRVDSKPEG GDSTQESESE EHWVGGGSDG
210 220 230 240 250
ESSHGDGSEL DDEGMQSDDP ESIRSERGNS RMNSAGMKSK ESGENSEQAN
260 270 280 290 300
TQDSGGSQLL EHPSRKIFRK SRISEEDDRS ELDDNNTMEE VKSDSTENSN
310 320 330 340 350
SRDTGLSQPR RDSKGDSQED SKENLSQEES QNVDGPSSES SQEANLSSQE
360 370 380 390 400
NSSESQEEVV SESRGDNPDP TTSYVEDQED SDSSEEDSSH TLSHSKSESR
410 420 430 440 450
EEQADSESSE SLNFSEESPE SPEDENSSSQ EGLQSHSSSA ESQSEESHSE
460 470 480 490 500
EDDSDSQDSS RSKEDSNSTE SKSSSEEDGQ LKNIEIESRK LTVDAYHNKP
510
IGDQDDNDCQ DGY
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_030750 | 69 | S → C2 PublicationsCorresponds to variant dbSNP:rs10019009EnsemblClinVar. | 1 | |
Natural variantiVAR_030751 | 117 | D → N in one individual with tumoral calcinosis. 1 PublicationCorresponds to variant dbSNP:rs140719182Ensembl. | 1 | |
Natural variantiVAR_030752 | 272 | R → H1 PublicationCorresponds to variant dbSNP:rs145237146EnsemblClinVar. | 1 | |
Natural variantiVAR_033848 | 463 | K → R. Corresponds to variant dbSNP:rs34661425EnsemblClinVar. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_004191 | 46 – 61 | Missing in isoform 2. 1 PublicationAdd BLAST | 16 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U89012 mRNA Translation: AAC51332.1 U34037 Genomic DNA Translation: AAA97602.1 CH471057 Genomic DNA Translation: EAX05996.1 BC130581 mRNA Translation: AAI30582.1 BC132865 mRNA Translation: AAI32866.1 U65378 mRNA Translation: AAB87728.1 |
CCDSi | CCDS3623.1 [Q13316-1] CCDS43249.1 [Q13316-2] |
RefSeqi | NP_001073380.1, NM_001079911.2 [Q13316-2] NP_004398.1, NM_004407.3 [Q13316-1] |
Genome annotation databases
Ensembli | ENST00000282479; ENSP00000282479; ENSG00000152592 [Q13316-2] ENST00000339673; ENSP00000340935; ENSG00000152592 [Q13316-1] |
GeneIDi | 1758 |
KEGGi | hsa:1758 |
UCSCi | uc003hqv.4, human [Q13316-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U89012 mRNA Translation: AAC51332.1 U34037 Genomic DNA Translation: AAA97602.1 CH471057 Genomic DNA Translation: EAX05996.1 BC130581 mRNA Translation: AAI30582.1 BC132865 mRNA Translation: AAI32866.1 U65378 mRNA Translation: AAB87728.1 |
CCDSi | CCDS3623.1 [Q13316-1] CCDS43249.1 [Q13316-2] |
RefSeqi | NP_001073380.1, NM_001079911.2 [Q13316-2] NP_004398.1, NM_004407.3 [Q13316-1] |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 108098, 2 interactors |
IntActi | Q13316, 1 interactor |
STRINGi | 9606.ENSP00000340935 |
PTM databases
GlyGeni | Q13316, 8 sites |
iPTMneti | Q13316 |
PhosphoSitePlusi | Q13316 |
Polymorphism and mutation databases
BioMutai | DMP1 |
DMDMi | 7673998 |
Proteomic databases
MassIVEi | Q13316 |
PaxDbi | Q13316 |
PeptideAtlasi | Q13316 |
PRIDEi | Q13316 |
ProteomicsDBi | 59304 [Q13316-1] 59305 [Q13316-2] |
Protocols and materials databases
Antibodypediai | 25470, 309 antibodies |
DNASUi | 1758 |
Genome annotation databases
Ensembli | ENST00000282479; ENSP00000282479; ENSG00000152592 [Q13316-2] ENST00000339673; ENSP00000340935; ENSG00000152592 [Q13316-1] |
GeneIDi | 1758 |
KEGGi | hsa:1758 |
UCSCi | uc003hqv.4, human [Q13316-1] |
Organism-specific databases
CTDi | 1758 |
DisGeNETi | 1758 |
EuPathDBi | HostDB:ENSG00000152592.13 |
GeneCardsi | DMP1 |
HGNCi | HGNC:2932, DMP1 |
HPAi | ENSG00000152592, Tissue enhanced (pituitary gland, testis) |
MalaCardsi | DMP1 |
MIMi | 241520, phenotype 600980, gene |
neXtProti | NX_Q13316 |
OpenTargetsi | ENSG00000152592 |
Orphaneti | 289176, Autosomal recessive hypophosphatemic rickets |
PharmGKBi | PA27379 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1181, Eukaryota |
GeneTreei | ENSGT00730000111375 |
HOGENOMi | CLU_040174_0_0_1 |
InParanoidi | Q13316 |
OMAi | ARYQNTE |
OrthoDBi | 1235561at2759 |
PhylomeDBi | Q13316 |
TreeFami | TF337029 |
Enzyme and pathway databases
PathwayCommonsi | Q13316 |
Reactomei | R-HSA-3000178, ECM proteoglycans R-HSA-381426, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-8957275, Post-translational protein phosphorylation |
SignaLinki | Q13316 |
Miscellaneous databases
BioGRID-ORCSi | 1758, 3 hits in 834 CRISPR screens |
GeneWikii | DMP1_(gene) |
GenomeRNAii | 1758 |
Pharosi | Q13316, Tbio |
PROi | PR:Q13316 |
RNActi | Q13316, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000152592, Expressed in tibia and 85 other tissues |
Genevisiblei | Q13316, HS |
Family and domain databases
InterProi | View protein in InterPro IPR009889, DMP1 |
PANTHERi | PTHR23400, PTHR23400, 1 hit |
Pfami | View protein in Pfam PF07263, DMP1, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | DMP1_HUMAN | |
Accessioni | Q13316Primary (citable) accession number: Q13316 Secondary accession number(s): A1L4L3, O43265 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 30, 2000 |
Last sequence update: | January 1, 1998 | |
Last modified: | December 2, 2020 | |
This is version 160 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 4
Human chromosome 4: entries, gene names and cross-references to MIM - Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations