UniProtKB - Q13310 (PABP4_HUMAN)
Protein
Polyadenylate-binding protein 4
Gene
PABPC4
Organism
Homo sapiens (Human)
Status
Functioni
Binds the poly(A) tail of mRNA. May be involved in cytoplasmic regulatory processes of mRNA metabolism. Can probably bind to cytoplasmic RNA sequences other than poly(A) in vivo (By similarity).By similarity
GO - Molecular functioni
- mRNA 3'-UTR binding Source: GO_Central
- poly(A) binding Source: MGI
- poly(U) RNA binding Source: MGI
- RNA binding Source: UniProtKB
GO - Biological processi
- blood coagulation Source: ProtInc
- myeloid cell development Source: Ensembl
- regulation of mRNA stability Source: Ensembl
- RNA catabolic process Source: ProtInc
- RNA processing Source: ProtInc
- translation Source: ProtInc
Keywordsi
Molecular function | RNA-binding |
Enzyme and pathway databases
PathwayCommonsi | Q13310 |
SIGNORi | Q13310 |
Names & Taxonomyi
Protein namesi | Recommended name: Polyadenylate-binding protein 4Short name: PABP-4 Short name: Poly(A)-binding protein 4 Alternative name(s): Activated-platelet protein 1 Short name: APP-1 Inducible poly(A)-binding protein Short name: iPABP |
Gene namesi | Name:PABPC4 Synonyms:APP1, PABP4 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000090621.13 |
HGNCi | HGNC:8557, PABPC4 |
MIMi | 603407, gene |
neXtProti | NX_Q13310 |
Subcellular locationi
Other locations
- Cytoplasm 1 Publication
Note: Localized in cytoplasmic mRNP granules containing untranslated mRNAs.
Cytosol
- cytosol Source: HPA
Nucleus
- nucleus Source: MGI
Other locations
- cytoplasm Source: MGI
- cytoplasmic stress granule Source: MGI
- ribonucleoprotein complex Source: UniProtKB
Keywords - Cellular componenti
CytoplasmPathology & Biotechi
Organism-specific databases
DisGeNETi | 8761 |
OpenTargetsi | ENSG00000090621 |
PharmGKBi | PA32883 |
Miscellaneous databases
Pharosi | Q13310, Tbio |
Chemistry databases
ChEMBLi | CHEMBL5333 |
Polymorphism and mutation databases
BioMutai | PABPC4 |
DMDMi | 12229875 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000081703 | 1 – 644 | Polyadenylate-binding protein 4Add BLAST | 644 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length | |
---|---|---|---|---|---|
Modified residuei | 140 | PhosphotyrosineCombined sources | 1 | ||
Modified residuei | 206 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 304 | PhosphothreonineCombined sources | 1 | ||
Modified residuei | 315 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 319 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 361 | N6,N6-dimethyllysine; alternate1 Publication | 1 | ||
Cross-linki | 361 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources | |||
Modified residuei | 364 | PhosphotyrosineCombined sources | 1 | ||
Cross-linki | 375 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | |||
Modified residuei | 419 | Omega-N-methylarginineCombined sources | 1 | ||
Modified residuei | 432 | Omega-N-methylarginineCombined sources | 1 | ||
Modified residuei | 436 | Omega-N-methylarginineCombined sources | 1 | ||
Modified residuei | 454 | Omega-N-methylarginineCombined sources | 1 | ||
Modified residuei | 518 | Dimethylated arginine1 Publication | 1 | ||
Modified residuei | 530 | Omega-N-methylarginineCombined sources | 1 | ||
Modified residuei | 531 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 584 | PhosphoserineCombined sources | 1 | ||
Isoform 2 (identifier: Q13310-2) | |||||
Modified residuei | 496 | Omega-N-methylarginineCombined sources | 1 |
Post-translational modificationi
Arg-518 is dimethylated, probably to asymmetric dimethylarginine.
Keywords - PTMi
Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | Q13310 |
jPOSTi | Q13310 |
MassIVEi | Q13310 |
MaxQBi | Q13310 |
PaxDbi | Q13310 |
PeptideAtlasi | Q13310 |
PRIDEi | Q13310 |
ProteomicsDBi | 59300 [Q13310-1] 59301 [Q13310-2] 59302 [Q13310-3] |
PTM databases
iPTMneti | Q13310 |
MetOSitei | Q13310 |
PhosphoSitePlusi | Q13310 |
SwissPalmi | Q13310 |
Expressioni
Tissue specificityi
Expressed at low levels in resting normal T cells; following T-cell activation, however, mRNA levels are rapidly up-regulated.
Gene expression databases
Bgeei | ENSG00000090621, Expressed in testis and 130 other tissues |
ExpressionAtlasi | Q13310, baseline and differential |
Genevisiblei | Q13310, HS |
Organism-specific databases
HPAi | ENSG00000090621, Tissue enhanced (pancreas, skeletal muscle) |
Interactioni
Subunit structurei
Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs.
Interacts with NFX1.
Interacts with ZFC3H1 in a RNase-sensitive manner (PubMed:27871484).
3 PublicationsBinary interactionsi
Q13310
With | #Exp. | IntAct |
---|---|---|
PHLDA1 [Q8WV24] | 2 | EBI-372844,EBI-738731 |
Protein-protein interaction databases
BioGRIDi | 114296, 203 interactors |
ELMi | Q13310 |
IntActi | Q13310, 79 interactors |
MINTi | Q13310 |
STRINGi | 9606.ENSP00000361949 |
Miscellaneous databases
RNActi | Q13310, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 11 – 89 | RRM 1PROSITE-ProRule annotationAdd BLAST | 79 | |
Domaini | 99 – 175 | RRM 2PROSITE-ProRule annotationAdd BLAST | 77 | |
Domaini | 191 – 268 | RRM 3PROSITE-ProRule annotationAdd BLAST | 78 | |
Domaini | 294 – 370 | RRM 4PROSITE-ProRule annotationAdd BLAST | 77 | |
Domaini | 551 – 628 | PABCPROSITE-ProRule annotationAdd BLAST | 78 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 510 – 516 | Poly-Ala | 7 |
Sequence similaritiesi
Belongs to the polyadenylate-binding protein type-1 family.Curated
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | KOG0123, Eukaryota |
GeneTreei | ENSGT00940000154788 |
InParanoidi | Q13310 |
OMAi | MQPAVFY |
OrthoDBi | 1027234at2759 |
PhylomeDBi | Q13310 |
TreeFami | TF300458 |
Family and domain databases
Gene3Di | 3.30.70.330, 4 hits |
InterProi | View protein in InterPro IPR012677, Nucleotide-bd_a/b_plait_sf IPR036053, PABP-dom IPR006515, PABP_1234 IPR002004, PABP_HYD IPR035979, RBD_domain_sf IPR000504, RRM_dom IPR003954, RRM_dom_euk |
Pfami | View protein in Pfam PF00658, PABP, 1 hit PF00076, RRM_1, 4 hits |
SMARTi | View protein in SMART SM00517, PolyA, 1 hit SM00360, RRM, 4 hits SM00361, RRM_1, 3 hits |
SUPFAMi | SSF54928, SSF54928, 2 hits SSF63570, SSF63570, 1 hit |
TIGRFAMsi | TIGR01628, PABP-1234, 1 hit |
PROSITEi | View protein in PROSITE PS51309, PABC, 1 hit PS50102, RRM, 4 hits |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 8 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q13310-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MNAAASSYPM ASLYVGDLHS DVTEAMLYEK FSPAGPVLSI RVCRDMITRR
60 70 80 90 100
SLGYAYVNFQ QPADAERALD TMNFDVIKGK PIRIMWSQRD PSLRKSGVGN
110 120 130 140 150
VFIKNLDKSI DNKALYDTFS AFGNILSCKV VCDENGSKGY AFVHFETQEA
160 170 180 190 200
ADKAIEKMNG MLLNDRKVFV GRFKSRKERE AELGAKAKEF TNVYIKNFGE
210 220 230 240 250
EVDDESLKEL FSQFGKTLSV KVMRDPNGKS KGFGFVSYEK HEDANKAVEE
260 270 280 290 300
MNGKEISGKI IFVGRAQKKV ERQAELKRKF EQLKQERISR YQGVNLYIKN
310 320 330 340 350
LDDTIDDEKL RKEFSPFGSI TSAKVMLEDG RSKGFGFVCF SSPEEATKAV
360 370 380 390 400
TEMNGRIVGS KPLYVALAQR KEERKAHLTN QYMQRVAGMR ALPANAILNQ
410 420 430 440 450
FQPAAGGYFV PAVPQAQGRP PYYTPNQLAQ MRPNPRWQQG GRPQGFQGMP
460 470 480 490 500
SAIRQSGPRP TLRHLAPTGS ECPDRLAMDF GGAGAAQQGL TDSCQSGGVP
510 520 530 540 550
TAVQNLAPRA AVAAAAPRAV APYKYASSVR SPHPAIQPLQ APQPAVHVQG
560 570 580 590 600
QEPLTASMLA AAPPQEQKQM LGERLFPLIQ TMHSNLAGKI TGMLLEIDNS
610 620 630 640
ELLHMLESPE SLRSKVDEAV AVLQAHHAKK EAAQKVGAVA AATS
Computationally mapped potential isoform sequencesi
There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketH0Y5F5 | H0Y5F5_HUMAN | Polyadenylate-binding protein | PABPC4 | 550 | Annotation score: | ||
B1ANR0 | B1ANR0_HUMAN | Polyadenylate-binding protein | PABPC4 hCG_2031827 | 615 | Annotation score: | ||
H0YEU6 | H0YEU6_HUMAN | Polyadenylate-binding protein 4 | PABPC4 | 249 | Annotation score: | ||
H0Y6X6 | H0Y6X6_HUMAN | Polyadenylate-binding protein 4 | PABPC4 | 195 | Annotation score: | ||
B1ANR1 | B1ANR1_HUMAN | Polyadenylate-binding protein 4 | PABPC4 | 129 | Annotation score: | ||
H0YCC8 | H0YCC8_HUMAN | Polyadenylate-binding protein 4 | PABPC4 | 197 | Annotation score: | ||
H0YEQ8 | H0YEQ8_HUMAN | Polyadenylate-binding protein 4 | PABPC4 | 112 | Annotation score: | ||
H0YER0 | H0YER0_HUMAN | Polyadenylate-binding protein 4 | PABPC4 | 68 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 114 | A → V in AAH65540 (PubMed:15489334).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_054048 | 382 | Y → F. Corresponds to variant dbSNP:rs9820Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_043357 | 468 | T → TGNAPASRGLPTTTQRV in isoform 3. 1 Publication | 1 | |
Alternative sequenceiVSP_013335 | 470 – 497 | SECPD…SCQSG → NAPASRGLPTTTQRV in isoform 2. 1 PublicationAdd BLAST | 28 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U33818 mRNA Translation: AAC50350.1 U75686 mRNA Translation: AAB97309.1 AL365277 Genomic DNA No translation available. AL845289 Genomic DNA No translation available. CH471059 Genomic DNA Translation: EAX07263.1 CH471059 Genomic DNA Translation: EAX07264.1 BC065540 mRNA Translation: AAH65540.1 BC094755 mRNA Translation: AAH94755.1 |
CCDSi | CCDS438.1 [Q13310-1] CCDS44114.1 [Q13310-2] CCDS44115.1 [Q13310-3] |
RefSeqi | NP_001129125.1, NM_001135653.1 [Q13310-3] NP_001129126.1, NM_001135654.1 [Q13310-2] NP_003810.1, NM_003819.3 [Q13310-1] |
Genome annotation databases
Ensembli | ENST00000372856; ENSP00000361947; ENSG00000090621 [Q13310-2] ENST00000372857; ENSP00000361948; ENSG00000090621 [Q13310-1] ENST00000372858; ENSP00000361949; ENSG00000090621 [Q13310-3] |
GeneIDi | 8761 |
KEGGi | hsa:8761 |
UCSCi | uc001cdl.3, human [Q13310-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U33818 mRNA Translation: AAC50350.1 U75686 mRNA Translation: AAB97309.1 AL365277 Genomic DNA No translation available. AL845289 Genomic DNA No translation available. CH471059 Genomic DNA Translation: EAX07263.1 CH471059 Genomic DNA Translation: EAX07264.1 BC065540 mRNA Translation: AAH65540.1 BC094755 mRNA Translation: AAH94755.1 |
CCDSi | CCDS438.1 [Q13310-1] CCDS44114.1 [Q13310-2] CCDS44115.1 [Q13310-3] |
RefSeqi | NP_001129125.1, NM_001135653.1 [Q13310-3] NP_001129126.1, NM_001135654.1 [Q13310-2] NP_003810.1, NM_003819.3 [Q13310-1] |
3D structure databases
SMRi | Q13310 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 114296, 203 interactors |
ELMi | Q13310 |
IntActi | Q13310, 79 interactors |
MINTi | Q13310 |
STRINGi | 9606.ENSP00000361949 |
Chemistry databases
ChEMBLi | CHEMBL5333 |
PTM databases
iPTMneti | Q13310 |
MetOSitei | Q13310 |
PhosphoSitePlusi | Q13310 |
SwissPalmi | Q13310 |
Polymorphism and mutation databases
BioMutai | PABPC4 |
DMDMi | 12229875 |
Proteomic databases
EPDi | Q13310 |
jPOSTi | Q13310 |
MassIVEi | Q13310 |
MaxQBi | Q13310 |
PaxDbi | Q13310 |
PeptideAtlasi | Q13310 |
PRIDEi | Q13310 |
ProteomicsDBi | 59300 [Q13310-1] 59301 [Q13310-2] 59302 [Q13310-3] |
Protocols and materials databases
Antibodypediai | 17821, 191 antibodies |
Genome annotation databases
Ensembli | ENST00000372856; ENSP00000361947; ENSG00000090621 [Q13310-2] ENST00000372857; ENSP00000361948; ENSG00000090621 [Q13310-1] ENST00000372858; ENSP00000361949; ENSG00000090621 [Q13310-3] |
GeneIDi | 8761 |
KEGGi | hsa:8761 |
UCSCi | uc001cdl.3, human [Q13310-1] |
Organism-specific databases
CTDi | 8761 |
DisGeNETi | 8761 |
EuPathDBi | HostDB:ENSG00000090621.13 |
GeneCardsi | PABPC4 |
HGNCi | HGNC:8557, PABPC4 |
HPAi | ENSG00000090621, Tissue enhanced (pancreas, skeletal muscle) |
MIMi | 603407, gene |
neXtProti | NX_Q13310 |
OpenTargetsi | ENSG00000090621 |
PharmGKBi | PA32883 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0123, Eukaryota |
GeneTreei | ENSGT00940000154788 |
InParanoidi | Q13310 |
OMAi | MQPAVFY |
OrthoDBi | 1027234at2759 |
PhylomeDBi | Q13310 |
TreeFami | TF300458 |
Enzyme and pathway databases
PathwayCommonsi | Q13310 |
SIGNORi | Q13310 |
Miscellaneous databases
BioGRID-ORCSi | 8761, 8 hits in 846 CRISPR screens |
ChiTaRSi | PABPC4, human |
GeneWikii | PABPC4 |
GenomeRNAii | 8761 |
Pharosi | Q13310, Tbio |
PROi | PR:Q13310 |
RNActi | Q13310, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000090621, Expressed in testis and 130 other tissues |
ExpressionAtlasi | Q13310, baseline and differential |
Genevisiblei | Q13310, HS |
Family and domain databases
Gene3Di | 3.30.70.330, 4 hits |
InterProi | View protein in InterPro IPR012677, Nucleotide-bd_a/b_plait_sf IPR036053, PABP-dom IPR006515, PABP_1234 IPR002004, PABP_HYD IPR035979, RBD_domain_sf IPR000504, RRM_dom IPR003954, RRM_dom_euk |
Pfami | View protein in Pfam PF00658, PABP, 1 hit PF00076, RRM_1, 4 hits |
SMARTi | View protein in SMART SM00517, PolyA, 1 hit SM00360, RRM, 4 hits SM00361, RRM_1, 3 hits |
SUPFAMi | SSF54928, SSF54928, 2 hits SSF63570, SSF63570, 1 hit |
TIGRFAMsi | TIGR01628, PABP-1234, 1 hit |
PROSITEi | View protein in PROSITE PS51309, PABC, 1 hit PS50102, RRM, 4 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | PABP4_HUMAN | |
Accessioni | Q13310Primary (citable) accession number: Q13310 Secondary accession number(s): B1ANQ8, Q4VC03, Q6P0N3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 1, 2000 |
Last sequence update: | November 1, 1996 | |
Last modified: | December 2, 2020 | |
This is version 207 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations