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UniProtKB - Q13310 (PABP4_HUMAN)

Entry version 199 (16 Oct 2019)
Sequence version 1 (01 Nov 1996)
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Protein

Polyadenylate-binding protein 4

Gene

PABPC4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Binds the poly(A) tail of mRNA. May be involved in cytoplasmic regulatory processes of mRNA metabolism. Can probably bind to cytoplasmic RNA sequences other than poly(A) in vivo (By similarity).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRNA-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Polyadenylate-binding protein 4
Short name:
PABP-4
Short name:
Poly(A)-binding protein 4
Alternative name(s):
Activated-platelet protein 1
Short name:
APP-1
Inducible poly(A)-binding protein
Short name:
iPABP
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PABPC4
Synonyms:APP1, PABP4
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:8557 PABPC4

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		603407 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q13310

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		8761

Open Targets

More...OpenTargetsi		ENSG00000090621

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA32883

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q13310

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL5333

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		PABPC4

Domain mapping of disease mutations (DMDM)

More...DMDMi		12229875

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000817031 – 644Polyadenylate-binding protein 4Add BLAST644

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei140PhosphotyrosineCombined sources1
Modified residuei206PhosphoserineCombined sources1
Modified residuei304PhosphothreonineCombined sources1
Modified residuei315PhosphoserineCombined sources1
Modified residuei319PhosphoserineCombined sources1
Modified residuei361N6,N6-dimethyllysine; alternate1 Publication1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki361Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Modified residuei364PhosphotyrosineCombined sources1
Cross-linki375Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei419Omega-N-methylarginineCombined sources1
Modified residuei432Omega-N-methylarginineCombined sources1
Modified residuei436Omega-N-methylarginineCombined sources1
Modified residuei454Omega-N-methylarginineCombined sources1
Modified residuei518Dimethylated arginine1 Publication1
Modified residuei530Omega-N-methylarginineCombined sources1
Modified residuei531PhosphoserineCombined sources1
Modified residuei584PhosphoserineCombined sources1
Isoform 2 (identifier: Q13310-2)
Modified residuei496Omega-N-methylarginineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Arg-518 is dimethylated, probably to asymmetric dimethylarginine.

Keywords - PTMi

Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q13310

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q13310

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q13310

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q13310

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q13310

PeptideAtlas

More...PeptideAtlasi		Q13310

PRoteomics IDEntifications database

More...PRIDEi		Q13310

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		59300 [Q13310-1]
59301 [Q13310-2]
59302 [Q13310-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q13310

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q13310

SwissPalm database of S-palmitoylation events

More...SwissPalmi		Q13310

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed at low levels in resting normal T cells; following T-cell activation, however, mRNA levels are rapidly up-regulated.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000090621 Expressed in 110 organ(s), highest expression level in testis

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q13310 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q13310 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		HPA027301
HPA056496

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs.

Interacts with NFX1.

Interacts with ZFC3H1 in a RNase-sensitive manner (PubMed:27871484).

3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
PHLDA1Q8WV242EBI-372844,EBI-738731

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		114296, 181 interactors

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...ELMi		Q13310

Protein interaction database and analysis system

More...IntActi		Q13310, 64 interactors

Molecular INTeraction database

More...MINTi		Q13310

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000361949

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q13310

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini11 – 89RRM 1PROSITE-ProRule annotationAdd BLAST79
Domaini99 – 175RRM 2PROSITE-ProRule annotationAdd BLAST77
Domaini191 – 268RRM 3PROSITE-ProRule annotationAdd BLAST78
Domaini294 – 370RRM 4PROSITE-ProRule annotationAdd BLAST77
Domaini551 – 628PABCPROSITE-ProRule annotationAdd BLAST78

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi510 – 516Poly-Ala7

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the polyadenylate-binding protein type-1 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0123 Eukaryota
ENOG410XR5X LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00940000154788

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		HOG000217922

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q13310

KEGG Orthology (KO)

More...KOi		K13126

Identification of Orthologs from Complete Genome Data

More...OMAi		MQPAVFY

Database of Orthologous Groups

More...OrthoDBi		1027234at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q13310

TreeFam database of animal gene trees

More...TreeFami		TF300458

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.30.70.330, 4 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR036053 PABP-dom
IPR006515 PABP_1234
IPR002004 PABP_HYD
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
IPR003954 RRM_dom_euk

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00658 PABP, 1 hit
PF00076 RRM_1, 4 hits

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00517 PolyA, 1 hit
SM00360 RRM, 4 hits
SM00361 RRM_1, 3 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF54928 SSF54928, 2 hits
SSF63570 SSF63570, 1 hit

TIGRFAMs; a protein family database

More...TIGRFAMsi		TIGR01628 PABP-1234, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51309 PABC, 1 hit
PS50102 RRM, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 8 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q13310-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MNAAASSYPM ASLYVGDLHS DVTEAMLYEK FSPAGPVLSI RVCRDMITRR 
        60         70         80         90        100
SLGYAYVNFQ QPADAERALD TMNFDVIKGK PIRIMWSQRD PSLRKSGVGN 
       110        120        130        140        150
VFIKNLDKSI DNKALYDTFS AFGNILSCKV VCDENGSKGY AFVHFETQEA 
       160        170        180        190        200
ADKAIEKMNG MLLNDRKVFV GRFKSRKERE AELGAKAKEF TNVYIKNFGE 
       210        220        230        240        250
EVDDESLKEL FSQFGKTLSV KVMRDPNGKS KGFGFVSYEK HEDANKAVEE 
       260        270        280        290        300
MNGKEISGKI IFVGRAQKKV ERQAELKRKF EQLKQERISR YQGVNLYIKN 
       310        320        330        340        350
LDDTIDDEKL RKEFSPFGSI TSAKVMLEDG RSKGFGFVCF SSPEEATKAV 
       360        370        380        390        400
TEMNGRIVGS KPLYVALAQR KEERKAHLTN QYMQRVAGMR ALPANAILNQ 
       410        420        430        440        450
FQPAAGGYFV PAVPQAQGRP PYYTPNQLAQ MRPNPRWQQG GRPQGFQGMP 
       460        470        480        490        500
SAIRQSGPRP TLRHLAPTGS ECPDRLAMDF GGAGAAQQGL TDSCQSGGVP 
       510        520        530        540        550
TAVQNLAPRA AVAAAAPRAV APYKYASSVR SPHPAIQPLQ APQPAVHVQG 
       560        570        580        590        600
QEPLTASMLA AAPPQEQKQM LGERLFPLIQ TMHSNLAGKI TGMLLEIDNS 
       610        620        630        640 
ELLHMLESPE SLRSKVDEAV AVLQAHHAKK EAAQKVGAVA AATS
Length:644
Mass (Da):70,783
Last modified:November 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA761488F0B10DF5A
GO
Isoform 2 (identifier: Q13310-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     470-497: SECPDRLAMDFGGAGAAQQGLTDSCQSG → NAPASRGLPTTTQRV

Note: No experimental confirmation available.Combined sources
Show »
Length:631
Mass (Da):69,579
Checksum:i1891E205916695F6
GO
Isoform 3 (identifier: Q13310-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     468-468: T → TGNAPASRGLPTTTQRV

Note: No experimental confirmation available.
Show »
Length:660
Mass (Da):72,391
Checksum:iBC4FB29689689633
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0Y5F5H0Y5F5_HUMAN
Polyadenylate-binding protein
PABPC4
550Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B1ANR0B1ANR0_HUMAN
Polyadenylate-binding protein
PABPC4 hCG_2031827
615Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YEU6H0YEU6_HUMAN
Polyadenylate-binding protein 4
PABPC4
249Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y6X6H0Y6X6_HUMAN
Polyadenylate-binding protein 4
PABPC4
195Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B1ANR1B1ANR1_HUMAN
Polyadenylate-binding protein 4
PABPC4
129Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YEQ8H0YEQ8_HUMAN
Polyadenylate-binding protein 4
PABPC4
112Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YCC8H0YCC8_HUMAN
Polyadenylate-binding protein 4
PABPC4
197Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YER0H0YER0_HUMAN
Polyadenylate-binding protein 4
PABPC4
68Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti114A → V in AAH65540 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_054048382Y → F. Corresponds to variant dbSNP:rs9820Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_043357468T → TGNAPASRGLPTTTQRV in isoform 3. 1 Publication1
Alternative sequenceiVSP_013335470 – 497SECPD…SCQSG → NAPASRGLPTTTQRV in isoform 2. 1 PublicationAdd BLAST28

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
U33818 mRNA Translation: AAC50350.1
U75686 mRNA Translation: AAB97309.1
AL365277 Genomic DNA No translation available.
AL845289 Genomic DNA No translation available.
CH471059 Genomic DNA Translation: EAX07263.1
CH471059 Genomic DNA Translation: EAX07264.1
BC065540 mRNA Translation: AAH65540.1
BC094755 mRNA Translation: AAH94755.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS438.1 [Q13310-1]
CCDS44114.1 [Q13310-2]
CCDS44115.1 [Q13310-3]

NCBI Reference Sequences

More...RefSeqi		NP_001129125.1, NM_001135653.1 [Q13310-3]
NP_001129126.1, NM_001135654.1 [Q13310-2]
NP_003810.1, NM_003819.3 [Q13310-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000372856; ENSP00000361947; ENSG00000090621 [Q13310-2]
ENST00000372857; ENSP00000361948; ENSG00000090621 [Q13310-1]
ENST00000372858; ENSP00000361949; ENSG00000090621 [Q13310-3]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		8761

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:8761

UCSC genome browser

More...UCSCi		uc001cdl.3 human [Q13310-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U33818 mRNA Translation: AAC50350.1
U75686 mRNA Translation: AAB97309.1
AL365277 Genomic DNA No translation available.
AL845289 Genomic DNA No translation available.
CH471059 Genomic DNA Translation: EAX07263.1
CH471059 Genomic DNA Translation: EAX07264.1
BC065540 mRNA Translation: AAH65540.1
BC094755 mRNA Translation: AAH94755.1
CCDSiCCDS438.1 [Q13310-1]
CCDS44114.1 [Q13310-2]
CCDS44115.1 [Q13310-3]
RefSeqiNP_001129125.1, NM_001135653.1 [Q13310-3]
NP_001129126.1, NM_001135654.1 [Q13310-2]
NP_003810.1, NM_003819.3 [Q13310-1]

3D structure databases

SMRiQ13310
ModBaseiSearch...

Protein-protein interaction databases

BioGridi114296, 181 interactors
ELMiQ13310
IntActiQ13310, 64 interactors
MINTiQ13310
STRINGi9606.ENSP00000361949

Chemistry databases

ChEMBLiCHEMBL5333

PTM databases

iPTMnetiQ13310
PhosphoSitePlusiQ13310
SwissPalmiQ13310

Polymorphism and mutation databases

BioMutaiPABPC4
DMDMi12229875

Proteomic databases

EPDiQ13310
jPOSTiQ13310
MassIVEiQ13310
MaxQBiQ13310
PaxDbiQ13310
PeptideAtlasiQ13310
PRIDEiQ13310
ProteomicsDBi59300 [Q13310-1]
59301 [Q13310-2]
59302 [Q13310-3]

Genome annotation databases

EnsembliENST00000372856; ENSP00000361947; ENSG00000090621 [Q13310-2]
ENST00000372857; ENSP00000361948; ENSG00000090621 [Q13310-1]
ENST00000372858; ENSP00000361949; ENSG00000090621 [Q13310-3]
GeneIDi8761
KEGGihsa:8761
UCSCiuc001cdl.3 human [Q13310-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		8761
DisGeNETi8761

GeneCards: human genes, protein and diseases

More...GeneCardsi		PABPC4
HGNCiHGNC:8557 PABPC4
HPAiHPA027301
HPA056496
MIMi603407 gene
neXtProtiNX_Q13310
OpenTargetsiENSG00000090621
PharmGKBiPA32883

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0123 Eukaryota
ENOG410XR5X LUCA
GeneTreeiENSGT00940000154788
HOGENOMiHOG000217922
InParanoidiQ13310
KOiK13126
OMAiMQPAVFY
OrthoDBi1027234at2759
PhylomeDBiQ13310
TreeFamiTF300458

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		PABPC4 human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		PABPC4

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		8761
PharosiQ13310

Protein Ontology

More...PROi		PR:Q13310

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000090621 Expressed in 110 organ(s), highest expression level in testis
ExpressionAtlasiQ13310 baseline and differential
GenevisibleiQ13310 HS

Family and domain databases

Gene3Di3.30.70.330, 4 hits
InterProiView protein in InterPro
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR036053 PABP-dom
IPR006515 PABP_1234
IPR002004 PABP_HYD
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
IPR003954 RRM_dom_euk
PfamiView protein in Pfam
PF00658 PABP, 1 hit
PF00076 RRM_1, 4 hits
SMARTiView protein in SMART
SM00517 PolyA, 1 hit
SM00360 RRM, 4 hits
SM00361 RRM_1, 3 hits
SUPFAMiSSF54928 SSF54928, 2 hits
SSF63570 SSF63570, 1 hit
TIGRFAMsiTIGR01628 PABP-1234, 1 hit
PROSITEiView protein in PROSITE
PS51309 PABC, 1 hit
PS50102 RRM, 4 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPABP4_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q13310
Secondary accession number(s): B1ANQ8, Q4VC03, Q6P0N3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1996
Last modified: October 16, 2019
This is version 199 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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