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UniProtKB - Q13310 (PABP4_HUMAN)

Protein

Polyadenylate-binding protein 4

Gene

PABPC4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds the poly(A) tail of mRNA. May be involved in cytoplasmic regulatory processes of mRNA metabolism. Can probably bind to cytoplasmic RNA sequences other than poly(A) in vivo (By similarity).By similarity

GO - Molecular functioni

  • mRNA 3'-UTR binding Source: GO_Central
  • poly(A) binding Source: MGI
  • poly(U) RNA binding Source: MGI
  • RNA binding Source: UniProtKB
View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

Keywordsi

Molecular functionRNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Polyadenylate-binding protein 4
Short name:
PABP-4
Short name:
Poly(A)-binding protein 4
Alternative name(s):
Activated-platelet protein 1
Short name:
APP-1
Inducible poly(A)-binding protein
Short name:
iPABP
Gene namesi
Name:PABPC4
Synonyms:APP1, PABP4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000090621.13
HGNCiHGNC:8557 PABPC4
MIMi603407 gene
neXtProtiNX_Q13310

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi8761
OpenTargetsiENSG00000090621
PharmGKBiPA32883

Chemistry databases

ChEMBLiCHEMBL5333

Polymorphism and mutation databases

BioMutaiPABPC4
DMDMi12229875

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000817031 – 644Polyadenylate-binding protein 4Add BLAST644

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei140PhosphotyrosineCombined sources1
Modified residuei206PhosphoserineCombined sources1
Modified residuei304PhosphothreonineCombined sources1
Modified residuei315PhosphoserineCombined sources1
Modified residuei319PhosphoserineCombined sources1
Modified residuei361N6,N6-dimethyllysine; alternate1 Publication1
Cross-linki361Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Modified residuei364PhosphotyrosineCombined sources1
Cross-linki375Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei419Omega-N-methylarginineCombined sources1
Modified residuei432Omega-N-methylarginineCombined sources1
Modified residuei436Omega-N-methylarginineCombined sources1
Modified residuei454Omega-N-methylarginineCombined sources1
Modified residuei518Dimethylated arginine1 Publication1
Modified residuei530Omega-N-methylarginineCombined sources1
Modified residuei531PhosphoserineCombined sources1
Modified residuei584PhosphoserineCombined sources1
Isoform 2 (identifier: Q13310-2)
Modified residuei496Omega-N-methylarginineCombined sources1

Post-translational modificationi

Arg-518 is dimethylated, probably to asymmetric dimethylarginine.

Keywords - PTMi

Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ13310
MaxQBiQ13310
PaxDbiQ13310
PeptideAtlasiQ13310
PRIDEiQ13310
ProteomicsDBi59300
59301 [Q13310-2]
59302 [Q13310-3]

PTM databases

iPTMnetiQ13310
PhosphoSitePlusiQ13310
SwissPalmiQ13310

Expressioni

Tissue specificityi

Expressed at low levels in resting normal T cells; following T-cell activation, however, mRNA levels are rapidly up-regulated.

Gene expression databases

BgeeiENSG00000090621 Expressed in 110 organ(s), highest expression level in testis
CleanExiHS_PABPC4
ExpressionAtlasiQ13310 baseline and differential
GenevisibleiQ13310 HS

Organism-specific databases

HPAiHPA027301
HPA056496

Interactioni

Subunit structurei

Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs. Interacts with NFX1. Interacts with ZFC3H1 in a RNase-sensitive manner (PubMed:27871484).3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
PHLDA1Q8WV242EBI-372844,EBI-738731

Protein-protein interaction databases

BioGridi114296, 150 interactors
ELMiQ13310
IntActiQ13310, 49 interactors
MINTiQ13310
STRINGi9606.ENSP00000361949

Structurei

3D structure databases

ProteinModelPortaliQ13310
SMRiQ13310
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini11 – 89RRM 1PROSITE-ProRule annotationAdd BLAST79
Domaini99 – 175RRM 2PROSITE-ProRule annotationAdd BLAST77
Domaini191 – 268RRM 3PROSITE-ProRule annotationAdd BLAST78
Domaini294 – 370RRM 4PROSITE-ProRule annotationAdd BLAST77
Domaini551 – 628PABCPROSITE-ProRule annotationAdd BLAST78

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi510 – 516Poly-Ala7

Sequence similaritiesi

Belongs to the polyadenylate-binding protein type-1 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0123 Eukaryota
ENOG410XR5X LUCA
GeneTreeiENSGT00760000118913
HOGENOMiHOG000217922
HOVERGENiHBG002295
InParanoidiQ13310
KOiK13126
OMAiRNQIRMQ
OrthoDBiEOG091G03ZE
PhylomeDBiQ13310
TreeFamiTF300458

Family and domain databases

Gene3Di3.30.70.330, 4 hits
InterProiView protein in InterPro
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR036053 PABP-dom
IPR006515 PABP_1234
IPR002004 PABP_HYD
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
IPR003954 RRM_dom_euk
PfamiView protein in Pfam
PF00658 PABP, 1 hit
PF00076 RRM_1, 4 hits
SMARTiView protein in SMART
SM00517 PolyA, 1 hit
SM00360 RRM, 4 hits
SM00361 RRM_1, 3 hits
SUPFAMiSSF54928 SSF54928, 2 hits
SSF63570 SSF63570, 1 hit
TIGRFAMsiTIGR01628 PABP-1234, 1 hit
PROSITEiView protein in PROSITE
PS51309 PABC, 1 hit
PS50102 RRM, 4 hits

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 8 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q13310-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MNAAASSYPM ASLYVGDLHS DVTEAMLYEK FSPAGPVLSI RVCRDMITRR 
        60         70         80         90        100
SLGYAYVNFQ QPADAERALD TMNFDVIKGK PIRIMWSQRD PSLRKSGVGN 
       110        120        130        140        150
VFIKNLDKSI DNKALYDTFS AFGNILSCKV VCDENGSKGY AFVHFETQEA 
       160        170        180        190        200
ADKAIEKMNG MLLNDRKVFV GRFKSRKERE AELGAKAKEF TNVYIKNFGE 
       210        220        230        240        250
EVDDESLKEL FSQFGKTLSV KVMRDPNGKS KGFGFVSYEK HEDANKAVEE 
       260        270        280        290        300
MNGKEISGKI IFVGRAQKKV ERQAELKRKF EQLKQERISR YQGVNLYIKN 
       310        320        330        340        350
LDDTIDDEKL RKEFSPFGSI TSAKVMLEDG RSKGFGFVCF SSPEEATKAV 
       360        370        380        390        400
TEMNGRIVGS KPLYVALAQR KEERKAHLTN QYMQRVAGMR ALPANAILNQ 
       410        420        430        440        450
FQPAAGGYFV PAVPQAQGRP PYYTPNQLAQ MRPNPRWQQG GRPQGFQGMP 
       460        470        480        490        500
SAIRQSGPRP TLRHLAPTGS ECPDRLAMDF GGAGAAQQGL TDSCQSGGVP 
       510        520        530        540        550
TAVQNLAPRA AVAAAAPRAV APYKYASSVR SPHPAIQPLQ APQPAVHVQG 
       560        570        580        590        600
QEPLTASMLA AAPPQEQKQM LGERLFPLIQ TMHSNLAGKI TGMLLEIDNS 
       610        620        630        640 
ELLHMLESPE SLRSKVDEAV AVLQAHHAKK EAAQKVGAVA AATS
Length:644
Mass (Da):70,783
Last modified:November 1, 1996 - v1
Checksum:iA761488F0B10DF5A
GO
Isoform 2 (identifier: Q13310-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     470-497: SECPDRLAMDFGGAGAAQQGLTDSCQSG → NAPASRGLPTTTQRV

Note: No experimental confirmation available.Combined sources
Show »
Length:631
Mass (Da):69,579
Checksum:i1891E205916695F6
GO
Isoform 3 (identifier: Q13310-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     468-468: T → TGNAPASRGLPTTTQRV

Note: No experimental confirmation available.
Show »
Length:660
Mass (Da):72,391
Checksum:iBC4FB29689689633
GO

Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B1ANR0B1ANR0_HUMAN
Polyadenylate-binding protein
PABPC4 hCG_2031827
615Annotation score:
H0Y5F5H0Y5F5_HUMAN
Polyadenylate-binding protein
PABPC4
550Annotation score:
H0YEU6H0YEU6_HUMAN
Polyadenylate-binding protein 4
PABPC4
249Annotation score:
B1ANR1B1ANR1_HUMAN
Polyadenylate-binding protein 4
PABPC4
129Annotation score:
H0YCC8H0YCC8_HUMAN
Polyadenylate-binding protein 4
PABPC4
197Annotation score:
H0YEQ8H0YEQ8_HUMAN
Polyadenylate-binding protein 4
PABPC4
112Annotation score:
H0Y6X6H0Y6X6_HUMAN
Polyadenylate-binding protein 4
PABPC4
195Annotation score:
H0YER0H0YER0_HUMAN
Polyadenylate-binding protein 4
PABPC4
68Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti114A → V in AAH65540 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_054048382Y → F. Corresponds to variant dbSNP:rs9820Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_043357468T → TGNAPASRGLPTTTQRV in isoform 3. 1 Publication1
Alternative sequenceiVSP_013335470 – 497SECPD…SCQSG → NAPASRGLPTTTQRV in isoform 2. 1 PublicationAdd BLAST28

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U33818 mRNA Translation: AAC50350.1
U75686 mRNA Translation: AAB97309.1
AL365277 Genomic DNA No translation available.
AL845289 Genomic DNA No translation available.
CH471059 Genomic DNA Translation: EAX07263.1
CH471059 Genomic DNA Translation: EAX07264.1
BC065540 mRNA Translation: AAH65540.1
BC094755 mRNA Translation: AAH94755.1
CCDSiCCDS438.1 [Q13310-1]
CCDS44114.1 [Q13310-2]
CCDS44115.1 [Q13310-3]
RefSeqiNP_001129125.1, NM_001135653.1 [Q13310-3]
NP_001129126.1, NM_001135654.1 [Q13310-2]
NP_003810.1, NM_003819.3 [Q13310-1]
UniGeneiHs.169900

Genome annotation databases

EnsembliENST00000372856; ENSP00000361947; ENSG00000090621 [Q13310-2]
ENST00000372857; ENSP00000361948; ENSG00000090621 [Q13310-1]
ENST00000372858; ENSP00000361949; ENSG00000090621 [Q13310-3]
GeneIDi8761
KEGGihsa:8761
UCSCiuc001cdl.3 human [Q13310-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U33818 mRNA Translation: AAC50350.1
U75686 mRNA Translation: AAB97309.1
AL365277 Genomic DNA No translation available.
AL845289 Genomic DNA No translation available.
CH471059 Genomic DNA Translation: EAX07263.1
CH471059 Genomic DNA Translation: EAX07264.1
BC065540 mRNA Translation: AAH65540.1
BC094755 mRNA Translation: AAH94755.1
CCDSiCCDS438.1 [Q13310-1]
CCDS44114.1 [Q13310-2]
CCDS44115.1 [Q13310-3]
RefSeqiNP_001129125.1, NM_001135653.1 [Q13310-3]
NP_001129126.1, NM_001135654.1 [Q13310-2]
NP_003810.1, NM_003819.3 [Q13310-1]
UniGeneiHs.169900

3D structure databases

ProteinModelPortaliQ13310
SMRiQ13310
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114296, 150 interactors
ELMiQ13310
IntActiQ13310, 49 interactors
MINTiQ13310
STRINGi9606.ENSP00000361949

Chemistry databases

ChEMBLiCHEMBL5333

PTM databases

iPTMnetiQ13310
PhosphoSitePlusiQ13310
SwissPalmiQ13310

Polymorphism and mutation databases

BioMutaiPABPC4
DMDMi12229875

Proteomic databases

EPDiQ13310
MaxQBiQ13310
PaxDbiQ13310
PeptideAtlasiQ13310
PRIDEiQ13310
ProteomicsDBi59300
59301 [Q13310-2]
59302 [Q13310-3]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000372856; ENSP00000361947; ENSG00000090621 [Q13310-2]
ENST00000372857; ENSP00000361948; ENSG00000090621 [Q13310-1]
ENST00000372858; ENSP00000361949; ENSG00000090621 [Q13310-3]
GeneIDi8761
KEGGihsa:8761
UCSCiuc001cdl.3 human [Q13310-1]

Organism-specific databases

CTDi8761
DisGeNETi8761
EuPathDBiHostDB:ENSG00000090621.13
GeneCardsiPABPC4
HGNCiHGNC:8557 PABPC4
HPAiHPA027301
HPA056496
MIMi603407 gene
neXtProtiNX_Q13310
OpenTargetsiENSG00000090621
PharmGKBiPA32883
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0123 Eukaryota
ENOG410XR5X LUCA
GeneTreeiENSGT00760000118913
HOGENOMiHOG000217922
HOVERGENiHBG002295
InParanoidiQ13310
KOiK13126
OMAiRNQIRMQ
OrthoDBiEOG091G03ZE
PhylomeDBiQ13310
TreeFamiTF300458

Miscellaneous databases

ChiTaRSiPABPC4 human
GeneWikiiPABPC4
GenomeRNAii8761
PROiPR:Q13310
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000090621 Expressed in 110 organ(s), highest expression level in testis
CleanExiHS_PABPC4
ExpressionAtlasiQ13310 baseline and differential
GenevisibleiQ13310 HS

Family and domain databases

Gene3Di3.30.70.330, 4 hits
InterProiView protein in InterPro
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR036053 PABP-dom
IPR006515 PABP_1234
IPR002004 PABP_HYD
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
IPR003954 RRM_dom_euk
PfamiView protein in Pfam
PF00658 PABP, 1 hit
PF00076 RRM_1, 4 hits
SMARTiView protein in SMART
SM00517 PolyA, 1 hit
SM00360 RRM, 4 hits
SM00361 RRM_1, 3 hits
SUPFAMiSSF54928 SSF54928, 2 hits
SSF63570 SSF63570, 1 hit
TIGRFAMsiTIGR01628 PABP-1234, 1 hit
PROSITEiView protein in PROSITE
PS51309 PABC, 1 hit
PS50102 RRM, 4 hits
ProtoNetiSearch...

Entry informationi

Entry nameiPABP4_HUMAN
AccessioniPrimary (citable) accession number: Q13310
Secondary accession number(s): B1ANQ8, Q4VC03, Q6P0N3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1996
Last modified: November 7, 2018
This is version 192 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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