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Entry version 192 (18 Sep 2019)
Sequence version 2 (17 Oct 2006)
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Protein

Inactive tyrosine-protein kinase 7

Gene

PTK7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Inactive tyrosine kinase involved in Wnt signaling pathway. Component of both the non-canonical (also known as the Wnt/planar cell polarity signaling) and the canonical Wnt signaling pathway. Functions in cell adhesion, cell migration, cell polarity, proliferation, actin cytoskeleton reorganization and apoptosis. Has a role in embryogenesis, epithelial tissue organization and angiogenesis.5 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionReceptor
Biological processCell adhesion, Wnt signaling pathway

Enzyme and pathway databases

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q13308

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Inactive tyrosine-protein kinase 7
Alternative name(s):
Colon carcinoma kinase 4
Short name:
CCK-4
Protein-tyrosine kinase 7
Pseudo tyrosine kinase receptor 7
Tyrosine-protein kinase-like 7
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PTK7
Synonyms:CCK4
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:9618 PTK7

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
601890 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q13308

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini31 – 704ExtracellularSequence analysisAdd BLAST674
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei705 – 725HelicalSequence analysisAdd BLAST21
Topological domaini726 – 1070CytoplasmicSequence analysisAdd BLAST345

Keywords - Cellular componenti

Cell junction, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi622L → D: Prevents proteolysis by MMP14. 1 Publication1
Mutagenesisi641M → R: No impact on proteolysis by MMP14. 1 Publication1
Mutagenesisi701M → D: No impact on proteolysis by MMP14. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
5754

Open Targets

More...
OpenTargetsi
ENSG00000112655

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA33961

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PTK7

Domain mapping of disease mutations (DMDM)

More...
DMDMi
116242736

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 30Sequence analysisAdd BLAST30
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001674831 – 1070Inactive tyrosine-protein kinase 7Add BLAST1040

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi53 ↔ 101PROSITE-ProRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi116N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi150 ↔ 200PROSITE-ProRule annotation
Glycosylationi175N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi184N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi214N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi246 ↔ 301PROSITE-ProRule annotation
Glycosylationi268N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi283N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi343 ↔ 391PROSITE-ProRule annotation
Glycosylationi405N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi433 ↔ 481PROSITE-ProRule annotation
Glycosylationi463N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi524 ↔ 570PROSITE-ProRule annotation
Glycosylationi567N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi613 ↔ 664PROSITE-ProRule annotation
Glycosylationi646N-linked (GlcNAc...) asparagine2 Publications1
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1064PhosphoserineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

MMP14 cleaves PTK7 between Pro-621 and Leu-622 generating an N-terminal soluble (70 kDa) fragment and a membrane C-terminal (50 kDa) fragment. Proteolysis by MMP14 regulates PTK7 function in non-canonical Wnt signaling pathway.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei621 – 622Cleavage; by MMP142

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q13308

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q13308

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q13308

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q13308

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q13308

PeptideAtlas

More...
PeptideAtlasi
Q13308

PRoteomics IDEntifications database

More...
PRIDEi
Q13308

ProteomicsDB human proteome resource

More...
ProteomicsDBi
20212
59293 [Q13308-1]
59294 [Q13308-2]
59295 [Q13308-3]
59296 [Q13308-4]
59297 [Q13308-5]

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
Q13308-3 [Q13308-3]

PTM databases

GlyConnect protein glycosylation platform

More...
GlyConnecti
655

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q13308

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q13308

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q13308

UniCarbKB; an annotated and curated database of glycan structures

More...
UniCarbKBi
Q13308

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in lung, liver, pancreas, kidney, placenta and melanocytes. Weakly expressed in thyroid gland, ovary, brain, heart and skeletal muscle. Also expressed in erythroleukemia cells. But not expressed in colon.

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Higher expression in cell lines established from normal non-tumorigenic tissues compared to cell lines established from highly metastatic invasive carcinomas (at protein level).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000112655 Expressed in 147 organ(s), highest expression level in myometrium

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q13308 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q13308 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA003222

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with CTNNB1.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
CTNNB1P352225EBI-2803245,EBI-491549

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
111721, 49 interactors

Protein interaction database and analysis system

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IntActi
Q13308, 49 interactors

Molecular INTeraction database

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MINTi
Q13308

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000418754

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q13308

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini31 – 120Ig-like C2-type 1Add BLAST90
Domaini128 – 218Ig-like C2-type 2Add BLAST91
Domaini225 – 317Ig-like C2-type 3Add BLAST93
Domaini309 – 407Ig-like C2-type 4Add BLAST99
Domaini412 – 497Ig-like C2-type 5Add BLAST86
Domaini503 – 586Ig-like C2-type 6Add BLAST84
Domaini578 – 680Ig-like C2-type 7Add BLAST103
Domaini796 – 1066Protein kinase; inactivePROSITE-ProRule annotationAdd BLAST271

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni794 – 1070Interaction with CTNNB11 PublicationAdd BLAST277

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The protein kinase domain is predicted to be catalytically inactive.

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG1026 Eukaryota
KOG4475 Eukaryota
COG0515 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157908

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000115767

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q13308

KEGG Orthology (KO)

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KOi
K05127

Identification of Orthologs from Complete Genome Data

More...
OMAi
GISHKGV

Database of Orthologous Groups

More...
OrthoDBi
1063560at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q13308

TreeFam database of animal gene trees

More...
TreeFami
TF326835

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
2.60.40.10, 7 hits

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
IPR008266 Tyr_kinase_AS

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07679 I-set, 3 hits
PF07714 Pkinase_Tyr, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR00109 TYRKINASE

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00409 IG, 7 hits
SM00408 IGc2, 7 hits

Superfamily database of structural and functional annotation

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SUPFAMi
SSF48726 SSF48726, 7 hits
SSF56112 SSF56112, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50835 IG_LIKE, 7 hits
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00109 PROTEIN_KINASE_TYR, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (6+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 6 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 6 described isoforms and 9 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q13308-1) [UniParc]FASTAAdd to basket
Also known as: PTK7-1

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGAARGSPAR PRRLPLLSVL LLPLLGGTQT AIVFIKQPSS QDALQGRRAL
60 70 80 90 100
LRCEVEAPGP VHVYWLLDGA PVQDTERRFA QGSSLSFAAV DRLQDSGTFQ
110 120 130 140 150
CVARDDVTGE EARSANASFN IKWIEAGPVV LKHPASEAEI QPQTQVTLRC
160 170 180 190 200
HIDGHPRPTY QWFRDGTPLS DGQSNHTVSS KERNLTLRPA GPEHSGLYSC
210 220 230 240 250
CAHSAFGQAC SSQNFTLSIA DESFARVVLA PQDVVVARYE EAMFHCQFSA
260 270 280 290 300
QPPPSLQWLF EDETPITNRS RPPHLRRATV FANGSLLLTQ VRPRNAGIYR
310 320 330 340 350
CIGQGQRGPP IILEATLHLA EIEDMPLFEP RVFTAGSEER VTCLPPKGLP
360 370 380 390 400
EPSVWWEHAG VRLPTHGRVY QKGHELVLAN IAESDAGVYT CHAANLAGQR
410 420 430 440 450
RQDVNITVAT VPSWLKKPQD SQLEEGKPGY LDCLTQATPK PTVVWYRNQM
460 470 480 490 500
LISEDSRFEV FKNGTLRINS VEVYDGTWYR CMSSTPAGSI EAQARVQVLE
510 520 530 540 550
KLKFTPPPQP QQCMEFDKEA TVPCSATGRE KPTIKWERAD GSSLPEWVTD
560 570 580 590 600
NAGTLHFARV TRDDAGNYTC IASNGPQGQI RAHVQLTVAV FITFKVEPER
610 620 630 640 650
TTVYQGHTAL LQCEAQGDPK PLIQWKGKDR ILDPTKLGPR MHIFQNGSLV
660 670 680 690 700
IHDVAPEDSG RYTCIAGNSC NIKHTEAPLY VVDKPVPEES EGPGSPPPYK
710 720 730 740 750
MIQTIGLSVG AAVAYIIAVL GLMFYCKKRC KAKRLQKQPE GEEPEMECLN
760 770 780 790 800
GGPLQNGQPS AEIQEEVALT SLGSGPAATN KRHSTSDKMH FPRSSLQPIT
810 820 830 840 850
TLGKSEFGEV FLAKAQGLEE GVAETLVLVK SLQSKDEQQQ LDFRRELEMF
860 870 880 890 900
GKLNHANVVR LLGLCREAEP HYMVLEYVDL GDLKQFLRIS KSKDEKLKSQ
910 920 930 940 950
PLSTKQKVAL CTQVALGMEH LSNNRFVHKD LAARNCLVSA QRQVKVSALG
960 970 980 990 1000
LSKDVYNSEY YHFRQAWVPL RWMSPEAILE GDFSTKSDVW AFGVLMWEVF
1010 1020 1030 1040 1050
THGEMPHGGQ ADDEVLADLQ AGKARLPQPE GCPSKLYRLM QRCWALSPKD
1060 1070
RPSFSEIASA LGDSTVDSKP
Length:1,070
Mass (Da):118,392
Last modified:October 17, 2006 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i304926A1774EB5F4
GO
Isoform 2 (identifier: Q13308-2) [UniParc]FASTAAdd to basket
Also known as: PTK7-2

The sequence of this isoform differs from the canonical sequence as follows:
     500-539: Missing.

Show »
Length:1,030
Mass (Da):113,805
Checksum:i34501D254ED02C49
GO
Isoform 3 (identifier: Q13308-3) [UniParc]FASTAAdd to basket
Also known as: PTK7-3

The sequence of this isoform differs from the canonical sequence as follows:
     410-540: TVPSWLKKPQ...KPTIKWERAD → N

Show »
Length:940
Mass (Da):103,581
Checksum:i33FEE51123972DA8
GO
Isoform 4 (identifier: Q13308-4) [UniParc]FASTAAdd to basket
Also known as: PTK7-4

The sequence of this isoform differs from the canonical sequence as follows:
     627-682: Missing.

Show »
Length:1,014
Mass (Da):112,261
Checksum:iBCAA8FEBBF9909B8
GO
Isoform 5 (identifier: Q13308-5) [UniParc]FASTAAdd to basket
Also known as: PTK7-5

The sequence of this isoform differs from the canonical sequence as follows:
     804-816: KSEFGEVFLAKAQ → RPQAVPEDFQEQG
     817-1070: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:816
Mass (Da):89,764
Checksum:i20405B0B94CA99EB
GO
Isoform 6 (identifier: Q13308-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-26: MGAARGSPARPRRLPLLSVLLLPLLG → MGSFLSGEKRPSAPTVGSAMEKKEFPTPPGRVGP

Note: No experimental confirmation available.
Show »
Length:1,078
Mass (Da):119,197
Checksum:iE5F3E9970734EAF8
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JQR6C9JQR6_HUMAN
Inactive tyrosine-protein kinase 7
PTK7
257Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y8F1H0Y8F1_HUMAN
Inactive tyrosine-protein kinase 7
PTK7
365Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q86X91Q86X91_HUMAN
Inactive tyrosine-protein kinase 7
PTK7 CCK4
459Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WCI7F8WCI7_HUMAN
Inactive tyrosine-protein kinase 7
PTK7
84Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J9E8C9J9E8_HUMAN
Inactive tyrosine-protein kinase 7
PTK7
139Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WDG7F8WDG7_HUMAN
Inactive tyrosine-protein kinase 7
PTK7
157Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C5L0H7C5L0_HUMAN
Inactive tyrosine-protein kinase 7
PTK7
269Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y889H0Y889_HUMAN
Inactive tyrosine-protein kinase 7
PTK7
25Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C4X3H7C4X3_HUMAN
Inactive tyrosine-protein kinase 7
PTK7
25Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti87F → L in BAF85278 (PubMed:14702039).Curated1
Sequence conflicti92R → P in AAA87565 (PubMed:7478540).Curated1
Sequence conflicti93L → P in AAH71557 (PubMed:15489334).Curated1
Sequence conflicti147T → K in AAA87565 (PubMed:7478540).Curated1
Sequence conflicti207G → S in AAA87565 (PubMed:7478540).Curated1
Sequence conflicti495 – 496RV → VL in AAA87565 (PubMed:7478540).Curated2
Sequence conflicti515E → G in AAA87565 (PubMed:7478540).Curated1
Sequence conflicti755Q → R in BAH12463 (PubMed:14702039).Curated1
Sequence conflicti799I → F in BAF85278 (PubMed:14702039).Curated1
Sequence conflicti881G → E in AAA87565 (PubMed:7478540).Curated1
Sequence conflicti969P → A in AAA87565 (PubMed:7478540).Curated1
Sequence conflicti992F → S in AAA87565 (PubMed:7478540).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_041502276R → H1 PublicationCorresponds to variant dbSNP:rs56188167Ensembl.1
Natural variantiVAR_041503410T → S1 PublicationCorresponds to variant dbSNP:rs34021075Ensembl.1
Natural variantiVAR_041504745E → D1 PublicationCorresponds to variant dbSNP:rs9472017Ensembl.1
Natural variantiVAR_041505766E → Q1 PublicationCorresponds to variant dbSNP:rs56216742Ensembl.1
Natural variantiVAR_041506777A → V1 PublicationCorresponds to variant dbSNP:rs34764696Ensembl.1
Natural variantiVAR_041507783H → R1 PublicationCorresponds to variant dbSNP:rs55820547Ensembl.1
Natural variantiVAR_041508933A → V in a colorectal adenocarcinoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_0415091029P → T1 PublicationCorresponds to variant dbSNP:rs55755163Ensembl.1
Natural variantiVAR_0415101038R → Q1 PublicationCorresponds to variant dbSNP:rs34865794Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0447751 – 26MGAAR…LPLLG → MGSFLSGEKRPSAPTVGSAM EKKEFPTPPGRVGP in isoform 6. 1 PublicationAdd BLAST26
Alternative sequenceiVSP_037181410 – 540TVPSW…WERAD → N in isoform 3. 1 PublicationAdd BLAST131
Alternative sequenceiVSP_037182500 – 539Missing in isoform 2. 2 PublicationsAdd BLAST40
Alternative sequenceiVSP_037183627 – 682Missing in isoform 4. 1 PublicationAdd BLAST56
Alternative sequenceiVSP_037184804 – 816KSEFG…LAKAQ → RPQAVPEDFQEQG in isoform 5. 1 PublicationAdd BLAST13
Alternative sequenceiVSP_037185817 – 1070Missing in isoform 5. 1 PublicationAdd BLAST254

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U33635 mRNA Translation: AAA87565.1
U40271 mRNA Translation: AAC50484.2
AF447176
, AF447157, AF447158, AF447162, AF447164, AF447167, AF447170, AF447171, AF447173, AF447174, AF447175 Genomic DNA Translation: AAL39062.1
AF531868 mRNA Translation: AAN04862.1
AF531869 mRNA Translation: AAN04863.1
AF531870 mRNA Translation: AAN04864.1
AF531871 mRNA Translation: AAN04865.1
AF531872 mRNA Translation: AAN04866.1
AK291016 mRNA Translation: BAF83705.1
AK292589 mRNA Translation: BAF85278.1
AK296953 mRNA Translation: BAH12463.1
AL355385 Genomic DNA No translation available.
CH471081 Genomic DNA Translation: EAX04154.1
CH471081 Genomic DNA Translation: EAX04155.1
CH471081 Genomic DNA Translation: EAX04156.1
CH471081 Genomic DNA Translation: EAX04158.1
CH471081 Genomic DNA Translation: EAX04160.1
BC071557 mRNA Translation: AAH71557.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS4884.1 [Q13308-1]
CCDS4885.1 [Q13308-2]
CCDS4886.1 [Q13308-3]
CCDS4887.1 [Q13308-4]
CCDS59021.1 [Q13308-6]

Protein sequence database of the Protein Information Resource

More...
PIRi
JC4593

NCBI Reference Sequences

More...
RefSeqi
NP_001257327.1, NM_001270398.1 [Q13308-6]
NP_002812.2, NM_002821.4 [Q13308-1]
NP_690619.1, NM_152880.3 [Q13308-2]
NP_690620.1, NM_152881.3 [Q13308-3]
NP_690621.1, NM_152882.3 [Q13308-4]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000230418; ENSP00000230418; ENSG00000112655 [Q13308-5]
ENST00000230419; ENSP00000230419; ENSG00000112655 [Q13308-1]
ENST00000345201; ENSP00000325992; ENSG00000112655 [Q13308-2]
ENST00000349241; ENSP00000325462; ENSG00000112655 [Q13308-3]
ENST00000352931; ENSP00000326029; ENSG00000112655 [Q13308-4]
ENST00000481273; ENSP00000418754; ENSG00000112655 [Q13308-6]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
5754

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:5754

UCSC genome browser

More...
UCSCi
uc003oub.3 human [Q13308-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U33635 mRNA Translation: AAA87565.1
U40271 mRNA Translation: AAC50484.2
AF447176
, AF447157, AF447158, AF447162, AF447164, AF447167, AF447170, AF447171, AF447173, AF447174, AF447175 Genomic DNA Translation: AAL39062.1
AF531868 mRNA Translation: AAN04862.1
AF531869 mRNA Translation: AAN04863.1
AF531870 mRNA Translation: AAN04864.1
AF531871 mRNA Translation: AAN04865.1
AF531872 mRNA Translation: AAN04866.1
AK291016 mRNA Translation: BAF83705.1
AK292589 mRNA Translation: BAF85278.1
AK296953 mRNA Translation: BAH12463.1
AL355385 Genomic DNA No translation available.
CH471081 Genomic DNA Translation: EAX04154.1
CH471081 Genomic DNA Translation: EAX04155.1
CH471081 Genomic DNA Translation: EAX04156.1
CH471081 Genomic DNA Translation: EAX04158.1
CH471081 Genomic DNA Translation: EAX04160.1
BC071557 mRNA Translation: AAH71557.1
CCDSiCCDS4884.1 [Q13308-1]
CCDS4885.1 [Q13308-2]
CCDS4886.1 [Q13308-3]
CCDS4887.1 [Q13308-4]
CCDS59021.1 [Q13308-6]
PIRiJC4593
RefSeqiNP_001257327.1, NM_001270398.1 [Q13308-6]
NP_002812.2, NM_002821.4 [Q13308-1]
NP_690619.1, NM_152880.3 [Q13308-2]
NP_690620.1, NM_152881.3 [Q13308-3]
NP_690621.1, NM_152882.3 [Q13308-4]

3D structure databases

SMRiQ13308
ModBaseiSearch...

Protein-protein interaction databases

BioGridi111721, 49 interactors
IntActiQ13308, 49 interactors
MINTiQ13308
STRINGi9606.ENSP00000418754

PTM databases

GlyConnecti655
iPTMnetiQ13308
PhosphoSitePlusiQ13308
SwissPalmiQ13308
UniCarbKBiQ13308

Polymorphism and mutation databases

BioMutaiPTK7
DMDMi116242736

Proteomic databases

EPDiQ13308
jPOSTiQ13308
MassIVEiQ13308
MaxQBiQ13308
PaxDbiQ13308
PeptideAtlasiQ13308
PRIDEiQ13308
ProteomicsDBi20212
59293 [Q13308-1]
59294 [Q13308-2]
59295 [Q13308-3]
59296 [Q13308-4]
59297 [Q13308-5]
TopDownProteomicsiQ13308-3 [Q13308-3]

Protocols and materials databases

ABCD curated depository of sequenced antibodies

More...
ABCDi
Q13308

The DNASU plasmid repository

More...
DNASUi
5754
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000230418; ENSP00000230418; ENSG00000112655 [Q13308-5]
ENST00000230419; ENSP00000230419; ENSG00000112655 [Q13308-1]
ENST00000345201; ENSP00000325992; ENSG00000112655 [Q13308-2]
ENST00000349241; ENSP00000325462; ENSG00000112655 [Q13308-3]
ENST00000352931; ENSP00000326029; ENSG00000112655 [Q13308-4]
ENST00000481273; ENSP00000418754; ENSG00000112655 [Q13308-6]
GeneIDi5754
KEGGihsa:5754
UCSCiuc003oub.3 human [Q13308-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
5754
DisGeNETi5754

GeneCards: human genes, protein and diseases

More...
GeneCardsi
PTK7
HGNCiHGNC:9618 PTK7
HPAiHPA003222
MIMi601890 gene
neXtProtiNX_Q13308
OpenTargetsiENSG00000112655
PharmGKBiPA33961

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1026 Eukaryota
KOG4475 Eukaryota
COG0515 LUCA
GeneTreeiENSGT00940000157908
HOGENOMiHOG000115767
InParanoidiQ13308
KOiK05127
OMAiGISHKGV
OrthoDBi1063560at2759
PhylomeDBiQ13308
TreeFamiTF326835

Enzyme and pathway databases

SIGNORiQ13308

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
PTK7 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
PTK7

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
5754

Pharos

More...
Pharosi
Q13308

Protein Ontology

More...
PROi
PR:Q13308

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000112655 Expressed in 147 organ(s), highest expression level in myometrium
ExpressionAtlasiQ13308 baseline and differential
GenevisibleiQ13308 HS

Family and domain databases

Gene3Di2.60.40.10, 7 hits
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
IPR008266 Tyr_kinase_AS
PfamiView protein in Pfam
PF07679 I-set, 3 hits
PF07714 Pkinase_Tyr, 1 hit
PRINTSiPR00109 TYRKINASE
SMARTiView protein in SMART
SM00409 IG, 7 hits
SM00408 IGc2, 7 hits
SUPFAMiSSF48726 SSF48726, 7 hits
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 7 hits
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00109 PROTEIN_KINASE_TYR, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPTK7_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q13308
Secondary accession number(s): A8K974
, B7Z477, E9PFZ5, Q13417, Q5T650, Q6IQ54, Q8NFA5, Q8NFA6, Q8NFA7, Q8NFA8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: October 17, 2006
Last modified: September 18, 2019
This is version 192 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  3. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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