UniProtKB - Q13308 (PTK7_HUMAN)
Inactive tyrosine-protein kinase 7
PTK7
Functioni
Inactive tyrosine kinase involved in Wnt signaling pathway. Component of both the non-canonical (also known as the Wnt/planar cell polarity signaling) and the canonical Wnt signaling pathway. Functions in cell adhesion, cell migration, cell polarity, proliferation, actin cytoskeleton reorganization and apoptosis. Has a role in embryogenesis, epithelial tissue organization and angiogenesis.
5 PublicationsGO - Molecular functioni
- ATP binding Source: InterPro
- cell adhesion molecule binding Source: GO_Central
- coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway Source: ParkinsonsUK-UCL
- protein kinase activity Source: InterPro
GO - Biological processi
- actin cytoskeleton reorganization Source: UniProtKB
- axis elongation Source: Ensembl
- cell adhesion Source: GO_Central
- cell migration Source: UniProtKB
- cellular response to retinoic acid Source: BHF-UCL
- cochlea morphogenesis Source: Ensembl
- convergent extension Source: Ensembl
- coronary vasculature development Source: Ensembl
- establishment of epithelial cell apical/basal polarity Source: Ensembl
- establishment of planar polarity Source: Ensembl
- kidney development Source: Ensembl
- lung-associated mesenchyme development Source: Ensembl
- planar cell polarity pathway involved in neural tube closure Source: Ensembl
- positive regulation of canonical Wnt signaling pathway Source: UniProtKB
- positive regulation of neuron projection development Source: BHF-UCL
- regulation of canonical Wnt signaling pathway Source: GO_Central
- signal transduction Source: ProtInc
- ventricular septum development Source: Ensembl
- wound healing Source: Ensembl
Keywordsi
Molecular function | Receptor |
Biological process | Cell adhesion, Wnt signaling pathway |
Enzyme and pathway databases
PathwayCommonsi | Q13308 |
SignaLinki | Q13308 |
SIGNORi | Q13308 |
Names & Taxonomyi
Protein namesi | Recommended name: Inactive tyrosine-protein kinase 7Alternative name(s): Colon carcinoma kinase 4 Short name: CCK-4 Protein-tyrosine kinase 7 Pseudo tyrosine kinase receptor 7 Tyrosine-protein kinase-like 7 |
Gene namesi | Name:PTK7 Synonyms:CCK4 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:9618, PTK7 |
MIMi | 601890, gene |
neXtProti | NX_Q13308 |
VEuPathDBi | HostDB:ENSG00000112655 |
Subcellular locationi
Other locations
- Membrane 1 Publication; Single-pass type I membrane protein 1 Publication
- Cell junction 1 Publication
Note: Colocalizes with MMP14 at cell junctions. Also localizes at the leading edge of migrating cells.
Plasma Membrane
- integral component of plasma membrane Source: ProtInc
- plasma membrane Source: GO_Central
Other locations
- cell-cell junction Source: UniProtKB
- focal adhesion Source: UniProtKB
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 31 – 704 | ExtracellularSequence analysisAdd BLAST | 674 | |
Transmembranei | 705 – 725 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 726 – 1070 | CytoplasmicSequence analysisAdd BLAST | 345 |
Keywords - Cellular componenti
Cell junction, MembranePathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 622 | L → D: Prevents proteolysis by MMP14. 1 Publication | 1 | |
Mutagenesisi | 641 | M → R: No impact on proteolysis by MMP14. 1 Publication | 1 | |
Mutagenesisi | 701 | M → D: No impact on proteolysis by MMP14. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 5754 |
OpenTargetsi | ENSG00000112655 |
PharmGKBi | PA33961 |
Miscellaneous databases
Pharosi | Q13308, Tbio |
Genetic variation databases
BioMutai | PTK7 |
DMDMi | 116242736 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 30 | Sequence analysisAdd BLAST | 30 | |
ChainiPRO_0000016748 | 31 – 1070 | Inactive tyrosine-protein kinase 7Add BLAST | 1040 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 53 ↔ 101 | PROSITE-ProRule annotation | ||
Glycosylationi | 116 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Disulfide bondi | 150 ↔ 200 | PROSITE-ProRule annotation | ||
Glycosylationi | 175 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Glycosylationi | 184 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 214 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 246 ↔ 301 | PROSITE-ProRule annotation | ||
Glycosylationi | 268 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Glycosylationi | 283 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Disulfide bondi | 343 ↔ 391 | PROSITE-ProRule annotation | ||
Glycosylationi | 405 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 433 ↔ 481 | PROSITE-ProRule annotation | ||
Glycosylationi | 463 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 524 ↔ 570 | PROSITE-ProRule annotation | ||
Glycosylationi | 567 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 613 ↔ 664 | PROSITE-ProRule annotation | ||
Glycosylationi | 646 | N-linked (GlcNAc...) asparagine2 Publications | 1 | |
Modified residuei | 1064 | PhosphoserineBy similarity | 1 |
Post-translational modificationi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 621 – 622 | Cleavage; by MMP14 | 2 |
Keywords - PTMi
Disulfide bond, Glycoprotein, PhosphoproteinProteomic databases
EPDi | Q13308 |
jPOSTi | Q13308 |
MassIVEi | Q13308 |
MaxQBi | Q13308 |
PaxDbi | Q13308 |
PeptideAtlasi | Q13308 |
PRIDEi | Q13308 |
ProteomicsDBi | 20212 59293 [Q13308-1] 59294 [Q13308-2] 59295 [Q13308-3] 59296 [Q13308-4] 59297 [Q13308-5] |
TopDownProteomicsi | Q13308-3 [Q13308-3] |
PTM databases
GlyConnecti | 655, 40 N-Linked glycans (6 sites) |
GlyGeni | Q13308, 11 sites, 46 N-linked glycans (6 sites), 1 O-linked glycan (1 site) |
iPTMneti | Q13308 |
MetOSitei | Q13308 |
PhosphoSitePlusi | Q13308 |
SwissPalmi | Q13308 |
Expressioni
Tissue specificityi
Inductioni
Gene expression databases
Bgeei | ENSG00000112655, Expressed in stromal cell of endometrium and 165 other tissues |
ExpressionAtlasi | Q13308, baseline and differential |
Genevisiblei | Q13308, HS |
Organism-specific databases
HPAi | ENSG00000112655, Low tissue specificity |
Interactioni
Subunit structurei
Interacts with CTNNB1.
1 PublicationBinary interactionsi
Q13308
GO - Molecular functioni
- cell adhesion molecule binding Source: GO_Central
Protein-protein interaction databases
BioGRIDi | 111721, 79 interactors |
IntActi | Q13308, 54 interactors |
MINTi | Q13308 |
STRINGi | 9606.ENSP00000418754 |
Miscellaneous databases
RNActi | Q13308, protein |
Structurei
Secondary structure
3D structure databases
SMRi | Q13308 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 31 – 120 | Ig-like C2-type 1Add BLAST | 90 | |
Domaini | 128 – 218 | Ig-like C2-type 2Add BLAST | 91 | |
Domaini | 225 – 317 | Ig-like C2-type 3Add BLAST | 93 | |
Domaini | 309 – 407 | Ig-like C2-type 4Add BLAST | 99 | |
Domaini | 412 – 497 | Ig-like C2-type 5Add BLAST | 86 | |
Domaini | 503 – 586 | Ig-like C2-type 6Add BLAST | 84 | |
Domaini | 578 – 680 | Ig-like C2-type 7Add BLAST | 103 | |
Domaini | 796 – 1066 | Protein kinase; inactivePROSITE-ProRule annotationAdd BLAST | 271 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 736 – 759 | DisorderedSequence analysisAdd BLAST | 24 | |
Regioni | 773 – 793 | DisorderedSequence analysisAdd BLAST | 21 | |
Regioni | 794 – 1070 | Interaction with CTNNB11 PublicationAdd BLAST | 277 |
Domaini
Sequence similaritiesi
Keywords - Domaini
Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG1026, Eukaryota KOG4475, Eukaryota |
GeneTreei | ENSGT00940000157908 |
HOGENOMi | CLU_012268_0_0_1 |
InParanoidi | Q13308 |
OMAi | PCLSKQR |
OrthoDBi | 530072at2759 |
PhylomeDBi | Q13308 |
TreeFami | TF326835 |
Family and domain databases
Gene3Di | 2.60.40.10, 7 hits |
InterProi | View protein in InterPro IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR013098, Ig_I-set IPR003599, Ig_sub IPR003598, Ig_sub2 IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR001245, Ser-Thr/Tyr_kinase_cat_dom IPR008266, Tyr_kinase_AS |
Pfami | View protein in Pfam PF07679, I-set, 3 hits PF07714, PK_Tyr_Ser-Thr, 1 hit |
PRINTSi | PR00109, TYRKINASE |
SMARTi | View protein in SMART SM00409, IG, 7 hits SM00408, IGc2, 7 hits |
SUPFAMi | SSF48726, SSF48726, 7 hits SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 7 hits PS50011, PROTEIN_KINASE_DOM, 1 hit PS00109, PROTEIN_KINASE_TYR, 1 hit |
s (6+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 6 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 6 described isoforms and 9 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MGAARGSPAR PRRLPLLSVL LLPLLGGTQT AIVFIKQPSS QDALQGRRAL
60 70 80 90 100
LRCEVEAPGP VHVYWLLDGA PVQDTERRFA QGSSLSFAAV DRLQDSGTFQ
110 120 130 140 150
CVARDDVTGE EARSANASFN IKWIEAGPVV LKHPASEAEI QPQTQVTLRC
160 170 180 190 200
HIDGHPRPTY QWFRDGTPLS DGQSNHTVSS KERNLTLRPA GPEHSGLYSC
210 220 230 240 250
CAHSAFGQAC SSQNFTLSIA DESFARVVLA PQDVVVARYE EAMFHCQFSA
260 270 280 290 300
QPPPSLQWLF EDETPITNRS RPPHLRRATV FANGSLLLTQ VRPRNAGIYR
310 320 330 340 350
CIGQGQRGPP IILEATLHLA EIEDMPLFEP RVFTAGSEER VTCLPPKGLP
360 370 380 390 400
EPSVWWEHAG VRLPTHGRVY QKGHELVLAN IAESDAGVYT CHAANLAGQR
410 420 430 440 450
RQDVNITVAT VPSWLKKPQD SQLEEGKPGY LDCLTQATPK PTVVWYRNQM
460 470 480 490 500
LISEDSRFEV FKNGTLRINS VEVYDGTWYR CMSSTPAGSI EAQARVQVLE
510 520 530 540 550
KLKFTPPPQP QQCMEFDKEA TVPCSATGRE KPTIKWERAD GSSLPEWVTD
560 570 580 590 600
NAGTLHFARV TRDDAGNYTC IASNGPQGQI RAHVQLTVAV FITFKVEPER
610 620 630 640 650
TTVYQGHTAL LQCEAQGDPK PLIQWKGKDR ILDPTKLGPR MHIFQNGSLV
660 670 680 690 700
IHDVAPEDSG RYTCIAGNSC NIKHTEAPLY VVDKPVPEES EGPGSPPPYK
710 720 730 740 750
MIQTIGLSVG AAVAYIIAVL GLMFYCKKRC KAKRLQKQPE GEEPEMECLN
760 770 780 790 800
GGPLQNGQPS AEIQEEVALT SLGSGPAATN KRHSTSDKMH FPRSSLQPIT
810 820 830 840 850
TLGKSEFGEV FLAKAQGLEE GVAETLVLVK SLQSKDEQQQ LDFRRELEMF
860 870 880 890 900
GKLNHANVVR LLGLCREAEP HYMVLEYVDL GDLKQFLRIS KSKDEKLKSQ
910 920 930 940 950
PLSTKQKVAL CTQVALGMEH LSNNRFVHKD LAARNCLVSA QRQVKVSALG
960 970 980 990 1000
LSKDVYNSEY YHFRQAWVPL RWMSPEAILE GDFSTKSDVW AFGVLMWEVF
1010 1020 1030 1040 1050
THGEMPHGGQ ADDEVLADLQ AGKARLPQPE GCPSKLYRLM QRCWALSPKD
1060 1070
RPSFSEIASA LGDSTVDSKP
The sequence of this isoform differs from the canonical sequence as follows:
804-816: KSEFGEVFLAKAQ → RPQAVPEDFQEQG
817-1070: Missing.
Computationally mapped potential isoform sequencesi
There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketC9J9E8 | C9J9E8_HUMAN | Inactive tyrosine-protein kinase 7 | PTK7 | 139 | Annotation score: | ||
C9JQR6 | C9JQR6_HUMAN | Inactive tyrosine-protein kinase 7 | PTK7 | 257 | Annotation score: | ||
H0Y8F1 | H0Y8F1_HUMAN | Inactive tyrosine-protein kinase 7 | PTK7 | 365 | Annotation score: | ||
Q86X91 | Q86X91_HUMAN | Inactive tyrosine-protein kinase 7 | PTK7 CCK4 | 459 | Annotation score: | ||
F8WCI7 | F8WCI7_HUMAN | Inactive tyrosine-protein kinase 7 | PTK7 | 84 | Annotation score: | ||
F8WDG7 | F8WDG7_HUMAN | Inactive tyrosine-protein kinase 7 | PTK7 | 157 | Annotation score: | ||
H7C5L0 | H7C5L0_HUMAN | Inactive tyrosine-protein kinase 7 | PTK7 | 269 | Annotation score: | ||
H0Y889 | H0Y889_HUMAN | Inactive tyrosine-protein kinase 7 | PTK7 | 25 | Annotation score: | ||
H7C4X3 | H7C4X3_HUMAN | Inactive tyrosine-protein kinase 7 | PTK7 | 25 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 87 | F → L in BAF85278 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 92 | R → P in AAA87565 (PubMed:7478540).Curated | 1 | |
Sequence conflicti | 93 | L → P in AAH71557 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 147 | T → K in AAA87565 (PubMed:7478540).Curated | 1 | |
Sequence conflicti | 207 | G → S in AAA87565 (PubMed:7478540).Curated | 1 | |
Sequence conflicti | 495 – 496 | RV → VL in AAA87565 (PubMed:7478540).Curated | 2 | |
Sequence conflicti | 515 | E → G in AAA87565 (PubMed:7478540).Curated | 1 | |
Sequence conflicti | 755 | Q → R in BAH12463 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 799 | I → F in BAF85278 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 881 | G → E in AAA87565 (PubMed:7478540).Curated | 1 | |
Sequence conflicti | 969 | P → A in AAA87565 (PubMed:7478540).Curated | 1 | |
Sequence conflicti | 992 | F → S in AAA87565 (PubMed:7478540).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_041502 | 276 | R → H1 PublicationCorresponds to variant dbSNP:rs56188167Ensembl. | 1 | |
Natural variantiVAR_041503 | 410 | T → S1 PublicationCorresponds to variant dbSNP:rs34021075Ensembl. | 1 | |
Natural variantiVAR_041504 | 745 | E → D1 PublicationCorresponds to variant dbSNP:rs9472017Ensembl. | 1 | |
Natural variantiVAR_041505 | 766 | E → Q1 PublicationCorresponds to variant dbSNP:rs56216742Ensembl. | 1 | |
Natural variantiVAR_041506 | 777 | A → V1 PublicationCorresponds to variant dbSNP:rs34764696Ensembl. | 1 | |
Natural variantiVAR_041507 | 783 | H → R1 PublicationCorresponds to variant dbSNP:rs55820547Ensembl. | 1 | |
Natural variantiVAR_041508 | 933 | A → V in a colorectal adenocarcinoma sample; somatic mutation. 1 Publication | 1 | |
Natural variantiVAR_041509 | 1029 | P → T1 PublicationCorresponds to variant dbSNP:rs55755163Ensembl. | 1 | |
Natural variantiVAR_041510 | 1038 | R → Q1 PublicationCorresponds to variant dbSNP:rs34865794Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_044775 | 1 – 26 | MGAAR…LPLLG → MGSFLSGEKRPSAPTVGSAM EKKEFPTPPGRVGP in isoform 6. 1 PublicationAdd BLAST | 26 | |
Alternative sequenceiVSP_037181 | 410 – 540 | TVPSW…WERAD → N in isoform 3. 1 PublicationAdd BLAST | 131 | |
Alternative sequenceiVSP_037182 | 500 – 539 | Missing in isoform 2. 2 PublicationsAdd BLAST | 40 | |
Alternative sequenceiVSP_037183 | 627 – 682 | Missing in isoform 4. 1 PublicationAdd BLAST | 56 | |
Alternative sequenceiVSP_037184 | 804 – 816 | KSEFG…LAKAQ → RPQAVPEDFQEQG in isoform 5. 1 PublicationAdd BLAST | 13 | |
Alternative sequenceiVSP_037185 | 817 – 1070 | Missing in isoform 5. 1 PublicationAdd BLAST | 254 |
Sequence databases
Genome annotation databases
Ensembli | ENST00000230418; ENSP00000230418; ENSG00000112655 [Q13308-5] ENST00000230419; ENSP00000230419; ENSG00000112655 ENST00000345201; ENSP00000325992; ENSG00000112655 [Q13308-2] ENST00000349241; ENSP00000325462; ENSG00000112655 [Q13308-3] ENST00000352931; ENSP00000326029; ENSG00000112655 [Q13308-4] ENST00000481273; ENSP00000418754; ENSG00000112655 [Q13308-6] |
GeneIDi | 5754 |
KEGGi | hsa:5754 |
MANE-Selecti | ENST00000230419.9; ENSP00000230419.4; NM_002821.5; NP_002812.2 |
UCSCi | uc003oub.3, human [Q13308-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Web resourcesi
Atlas of Genetics and Cytogenetics in Oncology and Haematology |
Sequence databases
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
6VG3 | X-ray | 1.95 | A/B/C | 774-1069 | [»] | |
SMRi | Q13308 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 111721, 79 interactors |
IntActi | Q13308, 54 interactors |
MINTi | Q13308 |
STRINGi | 9606.ENSP00000418754 |
PTM databases
GlyConnecti | 655, 40 N-Linked glycans (6 sites) |
GlyGeni | Q13308, 11 sites, 46 N-linked glycans (6 sites), 1 O-linked glycan (1 site) |
iPTMneti | Q13308 |
MetOSitei | Q13308 |
PhosphoSitePlusi | Q13308 |
SwissPalmi | Q13308 |
Genetic variation databases
BioMutai | PTK7 |
DMDMi | 116242736 |
Proteomic databases
EPDi | Q13308 |
jPOSTi | Q13308 |
MassIVEi | Q13308 |
MaxQBi | Q13308 |
PaxDbi | Q13308 |
PeptideAtlasi | Q13308 |
PRIDEi | Q13308 |
ProteomicsDBi | 20212 59293 [Q13308-1] 59294 [Q13308-2] 59295 [Q13308-3] 59296 [Q13308-4] 59297 [Q13308-5] |
TopDownProteomicsi | Q13308-3 [Q13308-3] |
Protocols and materials databases
ABCDi | Q13308, 1 sequenced antibody |
Antibodypediai | 1008, 592 antibodies from 38 providers |
DNASUi | 5754 |
Genome annotation databases
Ensembli | ENST00000230418; ENSP00000230418; ENSG00000112655 [Q13308-5] ENST00000230419; ENSP00000230419; ENSG00000112655 ENST00000345201; ENSP00000325992; ENSG00000112655 [Q13308-2] ENST00000349241; ENSP00000325462; ENSG00000112655 [Q13308-3] ENST00000352931; ENSP00000326029; ENSG00000112655 [Q13308-4] ENST00000481273; ENSP00000418754; ENSG00000112655 [Q13308-6] |
GeneIDi | 5754 |
KEGGi | hsa:5754 |
MANE-Selecti | ENST00000230419.9; ENSP00000230419.4; NM_002821.5; NP_002812.2 |
UCSCi | uc003oub.3, human [Q13308-1] |
Organism-specific databases
CTDi | 5754 |
DisGeNETi | 5754 |
GeneCardsi | PTK7 |
HGNCi | HGNC:9618, PTK7 |
HPAi | ENSG00000112655, Low tissue specificity |
MIMi | 601890, gene |
neXtProti | NX_Q13308 |
OpenTargetsi | ENSG00000112655 |
PharmGKBi | PA33961 |
VEuPathDBi | HostDB:ENSG00000112655 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1026, Eukaryota KOG4475, Eukaryota |
GeneTreei | ENSGT00940000157908 |
HOGENOMi | CLU_012268_0_0_1 |
InParanoidi | Q13308 |
OMAi | PCLSKQR |
OrthoDBi | 530072at2759 |
PhylomeDBi | Q13308 |
TreeFami | TF326835 |
Enzyme and pathway databases
PathwayCommonsi | Q13308 |
SignaLinki | Q13308 |
SIGNORi | Q13308 |
Miscellaneous databases
BioGRID-ORCSi | 5754, 13 hits in 1083 CRISPR screens |
ChiTaRSi | PTK7, human |
GeneWikii | PTK7 |
GenomeRNAii | 5754 |
Pharosi | Q13308, Tbio |
PROi | PR:Q13308 |
RNActi | Q13308, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000112655, Expressed in stromal cell of endometrium and 165 other tissues |
ExpressionAtlasi | Q13308, baseline and differential |
Genevisiblei | Q13308, HS |
Family and domain databases
Gene3Di | 2.60.40.10, 7 hits |
InterProi | View protein in InterPro IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR013098, Ig_I-set IPR003599, Ig_sub IPR003598, Ig_sub2 IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR001245, Ser-Thr/Tyr_kinase_cat_dom IPR008266, Tyr_kinase_AS |
Pfami | View protein in Pfam PF07679, I-set, 3 hits PF07714, PK_Tyr_Ser-Thr, 1 hit |
PRINTSi | PR00109, TYRKINASE |
SMARTi | View protein in SMART SM00409, IG, 7 hits SM00408, IGc2, 7 hits |
SUPFAMi | SSF48726, SSF48726, 7 hits SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 7 hits PS50011, PROTEIN_KINASE_DOM, 1 hit PS00109, PROTEIN_KINASE_TYR, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | PTK7_HUMAN | |
Accessioni | Q13308Primary (citable) accession number: Q13308 Secondary accession number(s): A8K974 Q8NFA8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 30, 2000 |
Last sequence update: | October 17, 2006 | |
Last modified: | February 23, 2022 | |
This is version 205 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human and mouse protein kinases
Human and mouse protein kinases: classification and index - Human chromosome 6
Human chromosome 6: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families