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UniProtKB - Q13304 (GPR17_HUMAN)

Entry version 170 (25 May 2022)
Sequence version 2 (27 May 2002)
Previous versions | rss
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Protein

Uracil nucleotide/cysteinyl leukotriene receptor

Gene

GPR17

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Dual specificity receptor for uracil nucleotides and cysteinyl leukotrienes (CysLTs). Signals through G(i) and inhibition of adenylyl cyclase. May mediate brain damage by nucleotides and CysLTs following ischemia.

1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q13304

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-391906, Leukotriene receptors
R-HSA-416476, G alpha (q) signalling events
R-HSA-417957, P2Y receptors
R-HSA-418594, G alpha (i) signalling events

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q13304

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q13304

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Uracil nucleotide/cysteinyl leukotriene receptor
Short name:
UDP/CysLT receptor
Alternative name(s):
G-protein coupled receptor 17
P2Y-like receptor
R12
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:GPR17
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:4471, GPR17

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		603071, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q13304

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000144230

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 64ExtracellularSequence analysisAdd BLAST64
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei65 – 85Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini86 – 92CytoplasmicSequence analysis7
Transmembranei93 – 113Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini114 – 133ExtracellularSequence analysisAdd BLAST20
Transmembranei134 – 154Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini155 – 175CytoplasmicSequence analysisAdd BLAST21
Transmembranei176 – 196Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini197 – 223ExtracellularSequence analysisAdd BLAST27
Transmembranei224 – 244Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini245 – 260CytoplasmicSequence analysisAdd BLAST16
Transmembranei261 – 281Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini282 – 308ExtracellularSequence analysisAdd BLAST27
Transmembranei309 – 329Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini330 – 367CytoplasmicSequence analysisAdd BLAST38

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		2840

MalaCards human disease database

More...MalaCardsi		GPR17

Open Targets

More...OpenTargetsi		ENSG00000144230

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA28859

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q13304, Tchem

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL1075162

DrugCentral

More...DrugCentrali		Q13304

IUPHAR/BPS Guide to PHARMACOLOGY

More...GuidetoPHARMACOLOGYi		88

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		GPR17

Domain mapping of disease mutations (DMDM)

More...DMDMi		21264435

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000695361 – 367Uracil nucleotide/cysteinyl leukotriene receptorAdd BLAST367

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi42N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi132 ↔ 209PROSITE-ProRule annotation
Glycosylationi204N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi282N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q13304

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q13304

PeptideAtlas

More...PeptideAtlasi		Q13304

PRoteomics IDEntifications database

More...PRIDEi		Q13304

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		59291 [Q13304-1]
59292 [Q13304-2]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q13304, 3 sites

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q13304

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q13304

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in brain, kidney, heart and umbilical vein endothelial cells. Highest level in brain.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000144230, Expressed in heart left ventricle and 129 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q13304, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q13304, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000144230, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		109099, 287 interactors

Protein interaction database and analysis system

More...IntActi		Q13304, 2 interactors

Molecular INTeraction database

More...MINTi		Q13304

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000442982

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		Q13304

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q13304, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		Q13304

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q13304

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 28DisorderedSequence analysisAdd BLAST28

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502QW6S, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT01040000240484

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_009579_8_2_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q13304

Identification of Orthologs from Complete Genome Data

More...OMAi		TCLNGAM

Database of Orthologous Groups

More...OrthoDBi		1166460at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q13304

TreeFam database of animal gene trees

More...TreeFami		TF330775

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR000276, GPCR_Rhodpsn
IPR017452, GPCR_Rhodpsn_7TM

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00001, 7tm_1, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00237, GPCRRHODOPSN

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00237, G_PROTEIN_RECEP_F1_1, 1 hit
PS50262, G_PROTEIN_RECEP_F1_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q13304-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSKRSWWAGS RKPPREMLKL SGSDSSQSMN GLEVAPPGLI TNFSLATAEQ 
        60         70         80         90        100
CGQETPLENM LFASFYLLDF ILALVGNTLA LWLFIRDHKS GTPANVFLMH 
       110        120        130        140        150
LAVADLSCVL VLPTRLVYHF SGNHWPFGEI ACRLTGFLFY LNMYASIYFL 
       160        170        180        190        200
TCISADRFLA IVHPVKSLKL RRPLYAHLAC AFLWVVVAVA MAPLLVSPQT 
       210        220        230        240        250
VQTNHTVVCL QLYREKASHH ALVSLAVAFT FPFITTVTCY LLIIRSLRQG 
       260        270        280        290        300
LRVEKRLKTK AVRMIAIVLA IFLVCFVPYH VNRSVYVLHY RSHGASCATQ 
       310        320        330        340        350
RILALANRIT SCLTSLNGAL DPIMYFFVAE KFRHALCNLL CGKRLKGPPP 
       360 
SFEGKTNESS LSAKSEL
Length:367
Mass (Da):40,989
Last modified:May 27, 2002 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i132FBE97BE83C60C
GO
Isoform 2 (identifier: Q13304-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-28: Missing.

Show »
Length:339
Mass (Da):37,827
Checksum:iBD2AEDB2FEBF15E1
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JWY5C9JWY5_HUMAN
Uracil nucleotide/cysteinyl leukotr...
GPR17
136Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti83L → F in AAH31653 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0019871 – 28Missing in isoform 2. 3 PublicationsAdd BLAST28

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
U33447 Genomic DNA Translation: AAB16746.1
Y12546 mRNA Translation: CAA73144.1
Z94154 mRNA Translation: CAB08107.1
Z94155 mRNA Translation: CAB08108.1
AK292725 mRNA Translation: BAF85414.1
AK313949 mRNA Translation: BAG36667.1
CH471103 Genomic DNA Translation: EAW95337.1
BC031653 mRNA Translation: AAH31653.1
BC039595 mRNA No translation available.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS2148.1 [Q13304-1]

NCBI Reference Sequences

More...RefSeqi		NP_001154887.1, NM_001161415.1 [Q13304-1]
NP_001154888.1, NM_001161416.1 [Q13304-2]
NP_001154889.1, NM_001161417.1 [Q13304-2]
NP_005282.1, NM_005291.2 [Q13304-1]
XP_016859322.1, XM_017003833.1 [Q13304-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000272644.7; ENSP00000272644.3; ENSG00000144230.17
ENST00000393018.3; ENSP00000376741.3; ENSG00000144230.17
ENST00000486700.2; ENSP00000508383.1; ENSG00000144230.17 [Q13304-2]
ENST00000544369.5; ENSP00000442982.1; ENSG00000144230.17

Database of genes from NCBI RefSeq genomes

More...GeneIDi		2840

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:2840

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000486700.2; ENSP00000508383.1; NM_001161417.2; NP_001154889.1 [Q13304-2]

UCSC genome browser

More...UCSCi		uc002tpc.4, human [Q13304-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U33447 Genomic DNA Translation: AAB16746.1
Y12546 mRNA Translation: CAA73144.1
Z94154 mRNA Translation: CAB08107.1
Z94155 mRNA Translation: CAB08108.1
AK292725 mRNA Translation: BAF85414.1
AK313949 mRNA Translation: BAG36667.1
CH471103 Genomic DNA Translation: EAW95337.1
BC031653 mRNA Translation: AAH31653.1
BC039595 mRNA No translation available.
CCDSiCCDS2148.1 [Q13304-1]
RefSeqiNP_001154887.1, NM_001161415.1 [Q13304-1]
NP_001154888.1, NM_001161416.1 [Q13304-2]
NP_001154889.1, NM_001161417.1 [Q13304-2]
NP_005282.1, NM_005291.2 [Q13304-1]
XP_016859322.1, XM_017003833.1 [Q13304-1]

3D structure databases

AlphaFoldDBiQ13304
SMRiQ13304
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi109099, 287 interactors
IntActiQ13304, 2 interactors
MINTiQ13304
STRINGi9606.ENSP00000442982

Chemistry databases

BindingDBiQ13304
ChEMBLiCHEMBL1075162
DrugCentraliQ13304
GuidetoPHARMACOLOGYi88

Protein family/group databases

Information system for G protein-coupled receptors (GPCRs)

More...GPCRDBi		Search...

PTM databases

GlyGeniQ13304, 3 sites
iPTMnetiQ13304
PhosphoSitePlusiQ13304

Genetic variation databases

BioMutaiGPR17
DMDMi21264435

Proteomic databases

MassIVEiQ13304
PaxDbiQ13304
PeptideAtlasiQ13304
PRIDEiQ13304
ProteomicsDBi59291 [Q13304-1]
59292 [Q13304-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		18483, 429 antibodies from 36 providers

The DNASU plasmid repository

More...DNASUi		2840

Genome annotation databases

EnsembliENST00000272644.7; ENSP00000272644.3; ENSG00000144230.17
ENST00000393018.3; ENSP00000376741.3; ENSG00000144230.17
ENST00000486700.2; ENSP00000508383.1; ENSG00000144230.17 [Q13304-2]
ENST00000544369.5; ENSP00000442982.1; ENSG00000144230.17
GeneIDi2840
KEGGihsa:2840
MANE-SelectiENST00000486700.2; ENSP00000508383.1; NM_001161417.2; NP_001154889.1 [Q13304-2]
UCSCiuc002tpc.4, human [Q13304-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		2840
DisGeNETi2840

GeneCards: human genes, protein and diseases

More...GeneCardsi		GPR17
HGNCiHGNC:4471, GPR17
HPAiENSG00000144230, Low tissue specificity
MalaCardsiGPR17
MIMi603071, gene
neXtProtiNX_Q13304
OpenTargetsiENSG00000144230
PharmGKBiPA28859
VEuPathDBiHostDB:ENSG00000144230

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502QW6S, Eukaryota
GeneTreeiENSGT01040000240484
HOGENOMiCLU_009579_8_2_1
InParanoidiQ13304
OMAiTCLNGAM
OrthoDBi1166460at2759
PhylomeDBiQ13304
TreeFamiTF330775

Enzyme and pathway databases

PathwayCommonsiQ13304
ReactomeiR-HSA-391906, Leukotriene receptors
R-HSA-416476, G alpha (q) signalling events
R-HSA-417957, P2Y receptors
R-HSA-418594, G alpha (i) signalling events
SignaLinkiQ13304
SIGNORiQ13304

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		2840, 90 hits in 1063 CRISPR screens

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		GPR17

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		2840
PharosiQ13304, Tchem

Protein Ontology

More...PROi		PR:Q13304
RNActiQ13304, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000144230, Expressed in heart left ventricle and 129 other tissues
ExpressionAtlasiQ13304, baseline and differential
GenevisibleiQ13304, HS

Family and domain databases

InterProiView protein in InterPro
IPR000276, GPCR_Rhodpsn
IPR017452, GPCR_Rhodpsn_7TM
PfamiView protein in Pfam
PF00001, 7tm_1, 1 hit
PRINTSiPR00237, GPCRRHODOPSN
PROSITEiView protein in PROSITE
PS00237, G_PROTEIN_RECEP_F1_1, 1 hit
PS50262, G_PROTEIN_RECEP_F1_2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGPR17_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q13304
Secondary accession number(s): A8K9L0
, B2R9X0, Q8N5S7, Q9UDZ6, Q9UE21
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 27, 2002
Last modified: May 25, 2022
This is version 170 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families
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