UniProtKB - Q13304 (GPR17_HUMAN)
Protein
Uracil nucleotide/cysteinyl leukotriene receptor
Gene
GPR17
Organism
Homo sapiens (Human)
Status
Functioni
Dual specificity receptor for uracil nucleotides and cysteinyl leukotrienes (CysLTs). Signals through G(i) and inhibition of adenylyl cyclase. May mediate brain damage by nucleotides and CysLTs following ischemia.1 Publication
GO - Molecular functioni
- chemokine receptor activity Source: ProtInc
- G protein-coupled receptor activity Source: GO_Central
- receptor serine/threonine kinase binding Source: Ensembl
GO - Biological processi
- G protein-coupled receptor signaling pathway Source: Reactome
- negative regulation of inflammatory response to antigenic stimulus Source: Ensembl
- oligodendrocyte differentiation Source: Ensembl
- positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway Source: GO_Central
- positive regulation of Rho protein signal transduction Source: GO_Central
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Enzyme and pathway databases
PathwayCommonsi | Q13304 |
Reactomei | R-HSA-391906, Leukotriene receptors R-HSA-416476, G alpha (q) signalling events R-HSA-417957, P2Y receptors R-HSA-418594, G alpha (i) signalling events |
SIGNORi | Q13304 |
Names & Taxonomyi
Protein namesi | Recommended name: Uracil nucleotide/cysteinyl leukotriene receptorShort name: UDP/CysLT receptor Alternative name(s): G-protein coupled receptor 17 P2Y-like receptor R12 |
Gene namesi | Name:GPR17 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:4471, GPR17 |
MIMi | 603071, gene |
neXtProti | NX_Q13304 |
VEuPathDBi | HostDB:ENSG00000144230.16 |
Subcellular locationi
Plasma membrane
Plasma Membrane
- integral component of plasma membrane Source: GO_Central
- plasma membrane Source: Reactome
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 64 | ExtracellularSequence analysisAdd BLAST | 64 | |
Transmembranei | 65 – 85 | Helical; Name=1Sequence analysisAdd BLAST | 21 | |
Topological domaini | 86 – 92 | CytoplasmicSequence analysis | 7 | |
Transmembranei | 93 – 113 | Helical; Name=2Sequence analysisAdd BLAST | 21 | |
Topological domaini | 114 – 133 | ExtracellularSequence analysisAdd BLAST | 20 | |
Transmembranei | 134 – 154 | Helical; Name=3Sequence analysisAdd BLAST | 21 | |
Topological domaini | 155 – 175 | CytoplasmicSequence analysisAdd BLAST | 21 | |
Transmembranei | 176 – 196 | Helical; Name=4Sequence analysisAdd BLAST | 21 | |
Topological domaini | 197 – 223 | ExtracellularSequence analysisAdd BLAST | 27 | |
Transmembranei | 224 – 244 | Helical; Name=5Sequence analysisAdd BLAST | 21 | |
Topological domaini | 245 – 260 | CytoplasmicSequence analysisAdd BLAST | 16 | |
Transmembranei | 261 – 281 | Helical; Name=6Sequence analysisAdd BLAST | 21 | |
Topological domaini | 282 – 308 | ExtracellularSequence analysisAdd BLAST | 27 | |
Transmembranei | 309 – 329 | Helical; Name=7Sequence analysisAdd BLAST | 21 | |
Topological domaini | 330 – 367 | CytoplasmicSequence analysisAdd BLAST | 38 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 2840 |
OpenTargetsi | ENSG00000144230 |
PharmGKBi | PA28859 |
Miscellaneous databases
Pharosi | Q13304, Tchem |
Chemistry databases
ChEMBLi | CHEMBL1075162 |
DrugCentrali | Q13304 |
GuidetoPHARMACOLOGYi | 88 |
Genetic variation databases
BioMutai | GPR17 |
DMDMi | 21264435 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000069536 | 1 – 367 | Uracil nucleotide/cysteinyl leukotriene receptorAdd BLAST | 367 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 42 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 132 ↔ 209 | PROSITE-ProRule annotation | ||
Glycosylationi | 204 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 282 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
MassIVEi | Q13304 |
PaxDbi | Q13304 |
PeptideAtlasi | Q13304 |
PRIDEi | Q13304 |
ProteomicsDBi | 59291 [Q13304-1] 59292 [Q13304-2] |
PTM databases
GlyGeni | Q13304, 3 sites |
iPTMneti | Q13304 |
PhosphoSitePlusi | Q13304 |
Expressioni
Tissue specificityi
Expressed in brain, kidney, heart and umbilical vein endothelial cells. Highest level in brain.1 Publication
Gene expression databases
Bgeei | ENSG00000144230, Expressed in heart left ventricle and 128 other tissues |
ExpressionAtlasi | Q13304, baseline and differential |
Genevisiblei | Q13304, HS |
Organism-specific databases
HPAi | ENSG00000144230, Tissue enhanced (brain) |
Interactioni
GO - Molecular functioni
- receptor serine/threonine kinase binding Source: Ensembl
Protein-protein interaction databases
BioGRIDi | 109099, 1 interactor |
IntActi | Q13304, 2 interactors |
MINTi | Q13304 |
STRINGi | 9606.ENSP00000442982 |
Chemistry databases
BindingDBi | Q13304 |
Miscellaneous databases
RNActi | Q13304, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502QW6S, Eukaryota |
GeneTreei | ENSGT01010000222496 |
HOGENOMi | CLU_009579_8_2_1 |
InParanoidi | Q13304 |
OMAi | FYVNMYA |
OrthoDBi | 1166460at2759 |
PhylomeDBi | Q13304 |
TreeFami | TF330775 |
Family and domain databases
InterProi | View protein in InterPro IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00237, GPCRRHODOPSN |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
Isoform 1 (identifier: Q13304-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSKRSWWAGS RKPPREMLKL SGSDSSQSMN GLEVAPPGLI TNFSLATAEQ
60 70 80 90 100
CGQETPLENM LFASFYLLDF ILALVGNTLA LWLFIRDHKS GTPANVFLMH
110 120 130 140 150
LAVADLSCVL VLPTRLVYHF SGNHWPFGEI ACRLTGFLFY LNMYASIYFL
160 170 180 190 200
TCISADRFLA IVHPVKSLKL RRPLYAHLAC AFLWVVVAVA MAPLLVSPQT
210 220 230 240 250
VQTNHTVVCL QLYREKASHH ALVSLAVAFT FPFITTVTCY LLIIRSLRQG
260 270 280 290 300
LRVEKRLKTK AVRMIAIVLA IFLVCFVPYH VNRSVYVLHY RSHGASCATQ
310 320 330 340 350
RILALANRIT SCLTSLNGAL DPIMYFFVAE KFRHALCNLL CGKRLKGPPP
360
SFEGKTNESS LSAKSEL
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketC9JWY5 | C9JWY5_HUMAN | Uracil nucleotide/cysteinyl leukotr... | GPR17 | 136 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 83 | L → F in AAH31653 (PubMed:15489334).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_001987 | 1 – 28 | Missing in isoform 2. 3 PublicationsAdd BLAST | 28 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U33447 Genomic DNA Translation: AAB16746.1 Y12546 mRNA Translation: CAA73144.1 Z94154 mRNA Translation: CAB08107.1 Z94155 mRNA Translation: CAB08108.1 AK292725 mRNA Translation: BAF85414.1 AK313949 mRNA Translation: BAG36667.1 CH471103 Genomic DNA Translation: EAW95337.1 BC031653 mRNA Translation: AAH31653.1 BC039595 mRNA No translation available. |
CCDSi | CCDS2148.1 [Q13304-1] |
RefSeqi | NP_001154887.1, NM_001161415.1 [Q13304-1] NP_001154888.1, NM_001161416.1 [Q13304-2] NP_001154889.1, NM_001161417.1 [Q13304-2] NP_005282.1, NM_005291.2 [Q13304-1] XP_016859322.1, XM_017003833.1 [Q13304-1] |
Genome annotation databases
Ensembli | ENST00000272644; ENSP00000272644; ENSG00000144230 [Q13304-1] ENST00000393018; ENSP00000376741; ENSG00000144230 [Q13304-1] ENST00000544369; ENSP00000442982; ENSG00000144230 [Q13304-1] |
GeneIDi | 2840 |
KEGGi | hsa:2840 |
UCSCi | uc002tpc.4, human [Q13304-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U33447 Genomic DNA Translation: AAB16746.1 Y12546 mRNA Translation: CAA73144.1 Z94154 mRNA Translation: CAB08107.1 Z94155 mRNA Translation: CAB08108.1 AK292725 mRNA Translation: BAF85414.1 AK313949 mRNA Translation: BAG36667.1 CH471103 Genomic DNA Translation: EAW95337.1 BC031653 mRNA Translation: AAH31653.1 BC039595 mRNA No translation available. |
CCDSi | CCDS2148.1 [Q13304-1] |
RefSeqi | NP_001154887.1, NM_001161415.1 [Q13304-1] NP_001154888.1, NM_001161416.1 [Q13304-2] NP_001154889.1, NM_001161417.1 [Q13304-2] NP_005282.1, NM_005291.2 [Q13304-1] XP_016859322.1, XM_017003833.1 [Q13304-1] |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 109099, 1 interactor |
IntActi | Q13304, 2 interactors |
MINTi | Q13304 |
STRINGi | 9606.ENSP00000442982 |
Chemistry databases
BindingDBi | Q13304 |
ChEMBLi | CHEMBL1075162 |
DrugCentrali | Q13304 |
GuidetoPHARMACOLOGYi | 88 |
Protein family/group databases
GPCRDBi | Search... |
PTM databases
GlyGeni | Q13304, 3 sites |
iPTMneti | Q13304 |
PhosphoSitePlusi | Q13304 |
Genetic variation databases
BioMutai | GPR17 |
DMDMi | 21264435 |
Proteomic databases
MassIVEi | Q13304 |
PaxDbi | Q13304 |
PeptideAtlasi | Q13304 |
PRIDEi | Q13304 |
ProteomicsDBi | 59291 [Q13304-1] 59292 [Q13304-2] |
Protocols and materials databases
Antibodypediai | 18483, 411 antibodies |
DNASUi | 2840 |
Genome annotation databases
Ensembli | ENST00000272644; ENSP00000272644; ENSG00000144230 [Q13304-1] ENST00000393018; ENSP00000376741; ENSG00000144230 [Q13304-1] ENST00000544369; ENSP00000442982; ENSG00000144230 [Q13304-1] |
GeneIDi | 2840 |
KEGGi | hsa:2840 |
UCSCi | uc002tpc.4, human [Q13304-1] |
Organism-specific databases
CTDi | 2840 |
DisGeNETi | 2840 |
GeneCardsi | GPR17 |
HGNCi | HGNC:4471, GPR17 |
HPAi | ENSG00000144230, Tissue enhanced (brain) |
MIMi | 603071, gene |
neXtProti | NX_Q13304 |
OpenTargetsi | ENSG00000144230 |
PharmGKBi | PA28859 |
VEuPathDBi | HostDB:ENSG00000144230.16 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QW6S, Eukaryota |
GeneTreei | ENSGT01010000222496 |
HOGENOMi | CLU_009579_8_2_1 |
InParanoidi | Q13304 |
OMAi | FYVNMYA |
OrthoDBi | 1166460at2759 |
PhylomeDBi | Q13304 |
TreeFami | TF330775 |
Enzyme and pathway databases
PathwayCommonsi | Q13304 |
Reactomei | R-HSA-391906, Leukotriene receptors R-HSA-416476, G alpha (q) signalling events R-HSA-417957, P2Y receptors R-HSA-418594, G alpha (i) signalling events |
SIGNORi | Q13304 |
Miscellaneous databases
BioGRID-ORCSi | 2840, 86 hits in 869 CRISPR screens |
GeneWikii | GPR17 |
GenomeRNAii | 2840 |
Pharosi | Q13304, Tchem |
PROi | PR:Q13304 |
RNActi | Q13304, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000144230, Expressed in heart left ventricle and 128 other tissues |
ExpressionAtlasi | Q13304, baseline and differential |
Genevisiblei | Q13304, HS |
Family and domain databases
InterProi | View protein in InterPro IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00237, GPCRRHODOPSN |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | GPR17_HUMAN | |
Accessioni | Q13304Primary (citable) accession number: Q13304 Secondary accession number(s): A8K9L0 Q9UE21 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | May 27, 2002 | |
Last modified: | February 10, 2021 | |
This is version 165 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM