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Protein

Uracil nucleotide/cysteinyl leukotriene receptor

Gene

GPR17

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Dual specificity receptor for uracil nucleotides and cysteinyl leukotrienes (CysLTs). Signals through G(i) and inhibition of adenylyl cyclase. May mediate brain damage by nucleotides and CysLTs following ischemia.1 Publication

GO - Molecular functioni

  • chemokine receptor activity Source: ProtInc
  • G protein-coupled receptor activity Source: GO_Central
  • receptor serine/threonine kinase binding Source: Ensembl

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-HSA-391906 Leukotriene receptors
R-HSA-416476 G alpha (q) signalling events
R-HSA-417957 P2Y receptors
R-HSA-418594 G alpha (i) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
Uracil nucleotide/cysteinyl leukotriene receptor
Short name:
UDP/CysLT receptor
Alternative name(s):
G-protein coupled receptor 17
P2Y-like receptor
R12
Gene namesi
Name:GPR17
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000144230.16
HGNCiHGNC:4471 GPR17
MIMi603071 gene
neXtProtiNX_Q13304

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 64ExtracellularSequence analysisAdd BLAST64
Transmembranei65 – 85Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini86 – 92CytoplasmicSequence analysis7
Transmembranei93 – 113Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini114 – 133ExtracellularSequence analysisAdd BLAST20
Transmembranei134 – 154Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini155 – 175CytoplasmicSequence analysisAdd BLAST21
Transmembranei176 – 196Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini197 – 223ExtracellularSequence analysisAdd BLAST27
Transmembranei224 – 244Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini245 – 260CytoplasmicSequence analysisAdd BLAST16
Transmembranei261 – 281Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini282 – 308ExtracellularSequence analysisAdd BLAST27
Transmembranei309 – 329Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini330 – 367CytoplasmicSequence analysisAdd BLAST38

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi2840
OpenTargetsiENSG00000144230
PharmGKBiPA28859

Chemistry databases

ChEMBLiCHEMBL1075162
GuidetoPHARMACOLOGYi88

Polymorphism and mutation databases

BioMutaiGPR17
DMDMi21264435

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000695361 – 367Uracil nucleotide/cysteinyl leukotriene receptorAdd BLAST367

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi42N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi132 ↔ 209PROSITE-ProRule annotation
Glycosylationi204N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi282N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ13304
PeptideAtlasiQ13304
PRIDEiQ13304
ProteomicsDBi59291
59292 [Q13304-2]

PTM databases

iPTMnetiQ13304
PhosphoSitePlusiQ13304

Expressioni

Tissue specificityi

Expressed in brain, kidney, heart and umbilical vein endothelial cells. Highest level in brain.1 Publication

Gene expression databases

BgeeiENSG00000144230 Expressed in 113 organ(s), highest expression level in heart left ventricle
CleanExiHS_GPR17
ExpressionAtlasiQ13304 baseline and differential
GenevisibleiQ13304 HS

Organism-specific databases

HPAiHPA029766

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi109099, 1 interactor
STRINGi9606.ENSP00000272644

Chemistry databases

BindingDBiQ13304

Structurei

3D structure databases

ProteinModelPortaliQ13304
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IGZC Eukaryota
ENOG41110RZ LUCA
GeneTreeiENSGT00920000148939
HOGENOMiHOG000236328
HOVERGENiHBG102010
InParanoidiQ13304
KOiK08404
OMAiFSGNHWP
OrthoDBiEOG091G0A8K
PhylomeDBiQ13304
TreeFamiTF330775

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q13304-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSKRSWWAGS RKPPREMLKL SGSDSSQSMN GLEVAPPGLI TNFSLATAEQ
60 70 80 90 100
CGQETPLENM LFASFYLLDF ILALVGNTLA LWLFIRDHKS GTPANVFLMH
110 120 130 140 150
LAVADLSCVL VLPTRLVYHF SGNHWPFGEI ACRLTGFLFY LNMYASIYFL
160 170 180 190 200
TCISADRFLA IVHPVKSLKL RRPLYAHLAC AFLWVVVAVA MAPLLVSPQT
210 220 230 240 250
VQTNHTVVCL QLYREKASHH ALVSLAVAFT FPFITTVTCY LLIIRSLRQG
260 270 280 290 300
LRVEKRLKTK AVRMIAIVLA IFLVCFVPYH VNRSVYVLHY RSHGASCATQ
310 320 330 340 350
RILALANRIT SCLTSLNGAL DPIMYFFVAE KFRHALCNLL CGKRLKGPPP
360
SFEGKTNESS LSAKSEL
Length:367
Mass (Da):40,989
Last modified:May 27, 2002 - v2
Checksum:i132FBE97BE83C60C
GO
Isoform 2 (identifier: Q13304-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-28: Missing.

Show »
Length:339
Mass (Da):37,827
Checksum:iBD2AEDB2FEBF15E1
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JWY5C9JWY5_HUMAN
Uracil nucleotide/cysteinyl leukotr...
GPR17
136Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti83L → F in AAH31653 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0019871 – 28Missing in isoform 2. 3 PublicationsAdd BLAST28

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U33447 Genomic DNA Translation: AAB16746.1
Y12546 mRNA Translation: CAA73144.1
Z94154 mRNA Translation: CAB08107.1
Z94155 mRNA Translation: CAB08108.1
AK292725 mRNA Translation: BAF85414.1
AK313949 mRNA Translation: BAG36667.1
CH471103 Genomic DNA Translation: EAW95337.1
BC031653 mRNA Translation: AAH31653.1
BC039595 mRNA No translation available.
CCDSiCCDS2148.1 [Q13304-1]
RefSeqiNP_001154887.1, NM_001161415.1 [Q13304-1]
NP_001154888.1, NM_001161416.1 [Q13304-2]
NP_001154889.1, NM_001161417.1 [Q13304-2]
NP_005282.1, NM_005291.2 [Q13304-1]
XP_016859322.1, XM_017003833.1 [Q13304-1]
UniGeneiHs.46453
Hs.736277

Genome annotation databases

EnsembliENST00000272644; ENSP00000272644; ENSG00000144230 [Q13304-1]
ENST00000393018; ENSP00000376741; ENSG00000144230 [Q13304-1]
ENST00000544369; ENSP00000442982; ENSG00000144230 [Q13304-1]
GeneIDi2840
KEGGihsa:2840
UCSCiuc002tpc.4 human [Q13304-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U33447 Genomic DNA Translation: AAB16746.1
Y12546 mRNA Translation: CAA73144.1
Z94154 mRNA Translation: CAB08107.1
Z94155 mRNA Translation: CAB08108.1
AK292725 mRNA Translation: BAF85414.1
AK313949 mRNA Translation: BAG36667.1
CH471103 Genomic DNA Translation: EAW95337.1
BC031653 mRNA Translation: AAH31653.1
BC039595 mRNA No translation available.
CCDSiCCDS2148.1 [Q13304-1]
RefSeqiNP_001154887.1, NM_001161415.1 [Q13304-1]
NP_001154888.1, NM_001161416.1 [Q13304-2]
NP_001154889.1, NM_001161417.1 [Q13304-2]
NP_005282.1, NM_005291.2 [Q13304-1]
XP_016859322.1, XM_017003833.1 [Q13304-1]
UniGeneiHs.46453
Hs.736277

3D structure databases

ProteinModelPortaliQ13304
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109099, 1 interactor
STRINGi9606.ENSP00000272644

Chemistry databases

BindingDBiQ13304
ChEMBLiCHEMBL1075162
GuidetoPHARMACOLOGYi88

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ13304
PhosphoSitePlusiQ13304

Polymorphism and mutation databases

BioMutaiGPR17
DMDMi21264435

Proteomic databases

PaxDbiQ13304
PeptideAtlasiQ13304
PRIDEiQ13304
ProteomicsDBi59291
59292 [Q13304-2]

Protocols and materials databases

DNASUi2840
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000272644; ENSP00000272644; ENSG00000144230 [Q13304-1]
ENST00000393018; ENSP00000376741; ENSG00000144230 [Q13304-1]
ENST00000544369; ENSP00000442982; ENSG00000144230 [Q13304-1]
GeneIDi2840
KEGGihsa:2840
UCSCiuc002tpc.4 human [Q13304-1]

Organism-specific databases

CTDi2840
DisGeNETi2840
EuPathDBiHostDB:ENSG00000144230.16
GeneCardsiGPR17
HGNCiHGNC:4471 GPR17
HPAiHPA029766
MIMi603071 gene
neXtProtiNX_Q13304
OpenTargetsiENSG00000144230
PharmGKBiPA28859
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IGZC Eukaryota
ENOG41110RZ LUCA
GeneTreeiENSGT00920000148939
HOGENOMiHOG000236328
HOVERGENiHBG102010
InParanoidiQ13304
KOiK08404
OMAiFSGNHWP
OrthoDBiEOG091G0A8K
PhylomeDBiQ13304
TreeFamiTF330775

Enzyme and pathway databases

ReactomeiR-HSA-391906 Leukotriene receptors
R-HSA-416476 G alpha (q) signalling events
R-HSA-417957 P2Y receptors
R-HSA-418594 G alpha (i) signalling events

Miscellaneous databases

GeneWikiiGPR17
GenomeRNAii2840
PROiPR:Q13304
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000144230 Expressed in 113 organ(s), highest expression level in heart left ventricle
CleanExiHS_GPR17
ExpressionAtlasiQ13304 baseline and differential
GenevisibleiQ13304 HS

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiGPR17_HUMAN
AccessioniPrimary (citable) accession number: Q13304
Secondary accession number(s): A8K9L0
, B2R9X0, Q8N5S7, Q9UDZ6, Q9UE21
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 27, 2002
Last modified: November 7, 2018
This is version 149 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
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