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Protein

Voltage-gated potassium channel subunit beta-2

Gene

KCNAB2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Cytoplasmic potassium channel subunit that modulates the characteristics of the channel-forming alpha-subunits (PubMed:7649300, PubMed:11825900). Contributes to the regulation of nerve signaling, and prevents neuronal hyperexcitability (By similarity). Promotes expression of the pore-forming alpha subunits at the cell membrane, and thereby increases channel activity (By similarity). Promotes potassium channel closure via a mechanism that does not involve physical obstruction of the channel pore (PubMed:7649300, PubMed:11825900). Promotes KCNA4 channel closure (PubMed:7649300, PubMed:11825900). Modulates the functional properties of KCNA5 (By similarity). Enhances KCNB2 channel activity (By similarity). Binds NADPH and has NADPH-dependent aldoketoreductase activity (By similarity). Has broad substrate specificity and can catalyze the reduction of methylglyoxal, 9,10-phenanthrenequinone, prostaglandin J2, 4-nitrobenzaldehyde, 4-nitroacetophenone and 4-oxo-trans-2-nonenal (in vitro) (By similarity).By similarity2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei63NADP1 Publication1
Binding sitei85NADP1 Publication1
Active sitei90Proton donor/acceptorBy similarity1
Binding sitei90NADP1 Publication1
Binding sitei214NADP1 Publication1
Binding sitei254NADP1 Publication1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi56 – 57NADP1 Publication2
Nucleotide bindingi188 – 189NADP1 Publication2
Nucleotide bindingi243 – 248NADP1 Publication6
Nucleotide bindingi323 – 329NADP1 Publication7

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIon channel, Oxidoreductase, Voltage-gated channel
Biological processIon transport, Potassium transport, Transport
LigandNADP, Potassium

Enzyme and pathway databases

ReactomeiR-HSA-1296072 Voltage gated Potassium channels
R-HSA-6798695 Neutrophil degranulation

Names & Taxonomyi

Protein namesi
Recommended name:
Voltage-gated potassium channel subunit beta-2 (EC:1.1.1.-By similarity)
Alternative name(s):
K(+) channel subunit beta-2
Kv-beta-2
Short name:
hKvbeta2
Gene namesi
Name:KCNAB2
Synonyms:KCNA2B, KCNK2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000069424.14
HGNCiHGNC:6229 KCNAB2
MIMi601142 gene
neXtProtiNX_Q13303

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell membrane, Cell projection, Cytoplasm, Cytoskeleton, Membrane, Synapse, Synaptosome

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi90Y → F: No effect on its activity in promoting KCNA4 channel closure. 1 Publication1

Organism-specific databases

DisGeNETi8514
MalaCardsiKCNAB2
OpenTargetsiENSG00000069424
Orphaneti1606 1p36 deletion syndrome
PharmGKBiPA373

Polymorphism and mutation databases

BioMutaiKCNAB2
DMDMi18202496

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001487461 – 367Voltage-gated potassium channel subunit beta-2Add BLAST367

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei9PhosphoserineCombined sources1
Modified residuei14PhosphoserineCombined sources1
Modified residuei20PhosphoserineBy similarity1
Modified residuei28Asymmetric dimethylarginine; alternateCombined sources1
Modified residuei28Omega-N-methylarginine; alternateBy similarity1
Modified residuei31Phosphoserine1 Publication1
Modified residuei112Phosphoserine1 Publication1
Modified residuei124N6-acetyllysineCombined sources1

Post-translational modificationi

Phosphorylated by PRKCZ; may be regulated by incorporation in a complex composed of PRKCZ and SQSTM1.By similarity

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

EPDiQ13303
MaxQBiQ13303
PaxDbiQ13303
PeptideAtlasiQ13303
PRIDEiQ13303
ProteomicsDBi59288
59289 [Q13303-2]
59290 [Q13303-3]

PTM databases

iPTMnetiQ13303
PhosphoSitePlusiQ13303

Expressioni

Tissue specificityi

Detected in myelinated nerve fibers in the spinal cord, in the juxtaparanodal region of the nodes of Ranvier, but also in the paranodal region (PubMed:11086297). Detected in hippocampus (at protein level) (PubMed:21357749). Detected in hippocampus (PubMed:7649300).3 Publications

Gene expression databases

BgeeiENSG00000069424 Expressed in 201 organ(s), highest expression level in anterior cingulate cortex
CleanExiHS_KCNAB2
HS_KCNK2
ExpressionAtlasiQ13303 baseline and differential
GenevisibleiQ13303 HS

Organism-specific databases

HPAiCAB001975

Interactioni

Subunit structurei

Homotetramer (By similarity). Interaction with tetrameric potassium channel alpha subunits gives rise to a heterooctamer (By similarity). Identified in potassium channel complexes containing KCNA1, KCNA2, KCNA4, KCNA5, KCNA6, KCNAB1 and KCNAB2 (By similarity). Interacts with KCNA1 (PubMed:11086297). Interacts with KCNA2 (PubMed:11086297). Interacts with KCNA4 and KCND3 (By similarity). Interacts with KCNA5 (By similarity). Interacts with KCNB2 (By similarity). Interacts (in unphosphorylated form) with MAPRE1 (By similarity). Forms a ternary complex with SQSTM1 and PRKCZ (By similarity).By similarity1 Publication

Protein-protein interaction databases

BioGridi114086, 37 interactors
IntActiQ13303, 13 interactors
STRINGi9606.ENSP00000367323

Structurei

Secondary structure

1367
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ13303
SMRiQ13303
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ13303

Family & Domainsi

Domaini

In contrast to KCNAB1, the shorter N-terminal domain of KCNAB2 cannot mediate closure of delayed rectifier potassium channels by physically obstructing the pore.1 Publication

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1575 Eukaryota
COG0667 LUCA
GeneTreeiENSGT00550000074567
HOGENOMiHOG000250283
HOVERGENiHBG052216
InParanoidiQ13303
KOiK04883
OMAiTWGRDTD
OrthoDBiEOG091G0KDN
PhylomeDBiQ13303
TreeFamiTF324563

Family and domain databases

CDDicd06660 Aldo_ket_red, 1 hit
Gene3Di3.20.20.100, 1 hit
InterProiView protein in InterPro
IPR005983 K_chnl_volt-dep_bsu_KCNAB
IPR005399 K_chnl_volt-dep_bsu_KCNAB-rel
IPR005401 K_chnl_volt-dep_bsu_KCNAB2
IPR023210 NADP_OxRdtase_dom
IPR036812 NADP_OxRdtase_dom_sf
PfamiView protein in Pfam
PF00248 Aldo_ket_red, 1 hit
PRINTSiPR01579 KCNAB2CHANEL
PR01577 KCNABCHANNEL
SUPFAMiSSF51430 SSF51430, 1 hit
TIGRFAMsiTIGR01293 Kv_beta, 1 hit

Sequences (5+)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q13303-1) [UniParc]FASTAAdd to basket
Also known as: KvB2.1

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MYPESTTGSP ARLSLRQTGS PGMIYSTRYG SPKRQLQFYR NLGKSGLRVS
60 70 80 90 100
CLGLGTWVTF GGQITDEMAE QLMTLAYDNG INLFDTAEVY AAGKAEVVLG
110 120 130 140 150
NIIKKKGWRR SSLVITTKIF WGGKAETERG LSRKHIIEGL KASLERLQLE
160 170 180 190 200
YVDVVFANRP DPNTPMEETV RAMTHVINQG MAMYWGTSRW SSMEIMEAYS
210 220 230 240 250
VARQFNLTPP ICEQAEYHMF QREKVEVQLP ELFHKIGVGA MTWSPLACGI
260 270 280 290 300
VSGKYDSGIP PYSRASLKGY QWLKDKILSE EGRRQQAKLK ELQAIAERLG
310 320 330 340 350
CTLPQLAIAW CLRNEGVSSV LLGASNADQL MENIGAIQVL PKLSSSIIHE
360
IDSILGNKPY SKKDYRS
Length:367
Mass (Da):41,000
Last modified:January 1, 1998 - v2
Checksum:i91A673F8992140DA
GO
Isoform 2 (identifier: Q13303-2) [UniParc]FASTAAdd to basket
Also known as: KvB2.2

The sequence of this isoform differs from the canonical sequence as follows:
     26-39: Missing.

Show »
Length:353
Mass (Da):39,287
Checksum:i7D59C8203AC5606F
GO
Isoform 3 (identifier: Q13303-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-38: MYPESTTGSP...YGSPKRQLQF → MLSMTYSESL...GCTAQRTGMK
     167-167: E → EGDPFSSSKSRTFIIE

Show »
Length:415
Mass (Da):46,527
Checksum:i3AD46E32E4B200AF
GO
Isoform 4 (identifier: Q13303-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-67: Missing.

Show »
Length:300
Mass (Da):33,657
Checksum:i3ADDAAE15216B737
GO
Isoform 5 (identifier: Q13303-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     340-367: LPKLSSSIIHEIDSILGNKPYSKKDYRS → RVRGPAGQRA...GELAFQQEQT

Note: No experimental confirmation available.
Show »
Length:395
Mass (Da):43,560
Checksum:i4E6CED2B3028BBB0
GO

Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5TG80Q5TG80_HUMAN
Voltage-gated potassium channel sub...
KCNAB2
254Annotation score:
Q5TG81Q5TG81_HUMAN
Voltage-gated potassium channel sub...
KCNAB2
253Annotation score:
Q5TG84Q5TG84_HUMAN
Voltage-gated potassium channel sub...
KCNAB2
173Annotation score:
Q5TG78Q5TG78_HUMAN
Voltage-gated potassium channel sub...
KCNAB2
51Annotation score:
K7EIR5K7EIR5_HUMAN
Voltage-gated potassium channel sub...
KCNAB2
162Annotation score:
K7EKU4K7EKU4_HUMAN
Voltage-gated potassium channel sub...
KCNAB2
122Annotation score:

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0443111 – 67Missing in isoform 4. 1 PublicationAdd BLAST67
Alternative sequenceiVSP_0411891 – 38MYPES…RQLQF → MLSMTYSESLRSVSSRCHSE WALHPVRQTDTLELQRLREV RAAAQARNMESFLRMHGLSL DGCTAQRTGMK in isoform 3. 1 PublicationAdd BLAST38
Alternative sequenceiVSP_00105426 – 39Missing in isoform 2. 1 PublicationAdd BLAST14
Alternative sequenceiVSP_041190167E → EGDPFSSSKSRTFIIE in isoform 3. 1 Publication1
Alternative sequenceiVSP_057282340 – 367LPKLS…KDYRS → RVRGPAGQRAHPSPSPVQCI LPGSSCVPGSVLGTQDAPVN HQSCAPGELAFQQEQT in isoform 5. 1 PublicationAdd BLAST28

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U33429 mRNA Translation: AAC50955.1
AF029749 mRNA Translation: AAB84170.1
AF044253 mRNA Translation: AAB99859.1
AK124696 mRNA Translation: BAG54071.1
AK131252 mRNA Translation: BAD18431.1
AK289819 mRNA Translation: BAF82508.1
AK315858 mRNA Translation: BAF98749.1
AL035406 Genomic DNA No translation available.
BC110351 mRNA Translation: AAI10352.1
BC126424 mRNA Translation: AAI26425.1
BC130413 mRNA Translation: AAI30414.1
CCDSiCCDS55.1 [Q13303-1]
CCDS55570.1 [Q13303-3]
CCDS55571.1 [Q13303-4]
CCDS56.1 [Q13303-2]
PIRiS66502
RefSeqiNP_001186789.1, NM_001199860.1 [Q13303-1]
NP_001186790.1, NM_001199861.1 [Q13303-1]
NP_001186791.1, NM_001199862.1 [Q13303-3]
NP_001186792.1, NM_001199863.1 [Q13303-4]
NP_003627.1, NM_003636.3 [Q13303-1]
NP_742128.1, NM_172130.2 [Q13303-2]
XP_005263571.1, XM_005263514.2 [Q13303-2]
XP_011540623.1, XM_011542321.2 [Q13303-5]
XP_011540624.1, XM_011542322.2 [Q13303-5]
UniGeneiHs.440497
Hs.735032

Genome annotation databases

EnsembliENST00000164247; ENSP00000164247; ENSG00000069424 [Q13303-1]
ENST00000341524; ENSP00000340824; ENSG00000069424 [Q13303-1]
ENST00000352527; ENSP00000318772; ENSG00000069424 [Q13303-2]
ENST00000378083; ENSP00000367323; ENSG00000069424 [Q13303-3]
ENST00000378092; ENSP00000367332; ENSG00000069424 [Q13303-2]
ENST00000378097; ENSP00000367337; ENSG00000069424 [Q13303-1]
ENST00000458166; ENSP00000396167; ENSG00000069424 [Q13303-4]
ENST00000602612; ENSP00000473602; ENSG00000069424 [Q13303-5]
GeneIDi8514
KEGGihsa:8514
UCSCiuc001alv.3 human [Q13303-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U33429 mRNA Translation: AAC50955.1
AF029749 mRNA Translation: AAB84170.1
AF044253 mRNA Translation: AAB99859.1
AK124696 mRNA Translation: BAG54071.1
AK131252 mRNA Translation: BAD18431.1
AK289819 mRNA Translation: BAF82508.1
AK315858 mRNA Translation: BAF98749.1
AL035406 Genomic DNA No translation available.
BC110351 mRNA Translation: AAI10352.1
BC126424 mRNA Translation: AAI26425.1
BC130413 mRNA Translation: AAI30414.1
CCDSiCCDS55.1 [Q13303-1]
CCDS55570.1 [Q13303-3]
CCDS55571.1 [Q13303-4]
CCDS56.1 [Q13303-2]
PIRiS66502
RefSeqiNP_001186789.1, NM_001199860.1 [Q13303-1]
NP_001186790.1, NM_001199861.1 [Q13303-1]
NP_001186791.1, NM_001199862.1 [Q13303-3]
NP_001186792.1, NM_001199863.1 [Q13303-4]
NP_003627.1, NM_003636.3 [Q13303-1]
NP_742128.1, NM_172130.2 [Q13303-2]
XP_005263571.1, XM_005263514.2 [Q13303-2]
XP_011540623.1, XM_011542321.2 [Q13303-5]
XP_011540624.1, XM_011542322.2 [Q13303-5]
UniGeneiHs.440497
Hs.735032

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1ZSXX-ray1.90A39-360[»]
ProteinModelPortaliQ13303
SMRiQ13303
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114086, 37 interactors
IntActiQ13303, 13 interactors
STRINGi9606.ENSP00000367323

PTM databases

iPTMnetiQ13303
PhosphoSitePlusiQ13303

Polymorphism and mutation databases

BioMutaiKCNAB2
DMDMi18202496

Proteomic databases

EPDiQ13303
MaxQBiQ13303
PaxDbiQ13303
PeptideAtlasiQ13303
PRIDEiQ13303
ProteomicsDBi59288
59289 [Q13303-2]
59290 [Q13303-3]

Protocols and materials databases

DNASUi8514
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000164247; ENSP00000164247; ENSG00000069424 [Q13303-1]
ENST00000341524; ENSP00000340824; ENSG00000069424 [Q13303-1]
ENST00000352527; ENSP00000318772; ENSG00000069424 [Q13303-2]
ENST00000378083; ENSP00000367323; ENSG00000069424 [Q13303-3]
ENST00000378092; ENSP00000367332; ENSG00000069424 [Q13303-2]
ENST00000378097; ENSP00000367337; ENSG00000069424 [Q13303-1]
ENST00000458166; ENSP00000396167; ENSG00000069424 [Q13303-4]
ENST00000602612; ENSP00000473602; ENSG00000069424 [Q13303-5]
GeneIDi8514
KEGGihsa:8514
UCSCiuc001alv.3 human [Q13303-1]

Organism-specific databases

CTDi8514
DisGeNETi8514
EuPathDBiHostDB:ENSG00000069424.14
GeneCardsiKCNAB2
HGNCiHGNC:6229 KCNAB2
HPAiCAB001975
MalaCardsiKCNAB2
MIMi601142 gene
neXtProtiNX_Q13303
OpenTargetsiENSG00000069424
Orphaneti1606 1p36 deletion syndrome
PharmGKBiPA373
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1575 Eukaryota
COG0667 LUCA
GeneTreeiENSGT00550000074567
HOGENOMiHOG000250283
HOVERGENiHBG052216
InParanoidiQ13303
KOiK04883
OMAiTWGRDTD
OrthoDBiEOG091G0KDN
PhylomeDBiQ13303
TreeFamiTF324563

Enzyme and pathway databases

ReactomeiR-HSA-1296072 Voltage gated Potassium channels
R-HSA-6798695 Neutrophil degranulation

Miscellaneous databases

ChiTaRSiKCNAB2 human
EvolutionaryTraceiQ13303
GeneWikiiKCNAB2
GenomeRNAii8514
PROiPR:Q13303
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000069424 Expressed in 201 organ(s), highest expression level in anterior cingulate cortex
CleanExiHS_KCNAB2
HS_KCNK2
ExpressionAtlasiQ13303 baseline and differential
GenevisibleiQ13303 HS

Family and domain databases

CDDicd06660 Aldo_ket_red, 1 hit
Gene3Di3.20.20.100, 1 hit
InterProiView protein in InterPro
IPR005983 K_chnl_volt-dep_bsu_KCNAB
IPR005399 K_chnl_volt-dep_bsu_KCNAB-rel
IPR005401 K_chnl_volt-dep_bsu_KCNAB2
IPR023210 NADP_OxRdtase_dom
IPR036812 NADP_OxRdtase_dom_sf
PfamiView protein in Pfam
PF00248 Aldo_ket_red, 1 hit
PRINTSiPR01579 KCNAB2CHANEL
PR01577 KCNABCHANNEL
SUPFAMiSSF51430 SSF51430, 1 hit
TIGRFAMsiTIGR01293 Kv_beta, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiKCAB2_HUMAN
AccessioniPrimary (citable) accession number: Q13303
Secondary accession number(s): A0AVM9
, A8K1A4, B0AZR7, O43659, Q2YD85, Q5TG82, Q5TG83, Q6ZNE4, Q99411
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 18, 2001
Last sequence update: January 1, 1998
Last modified: September 12, 2018
This is version 175 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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