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UniProtKB - Q13303 (KCAB2_HUMAN)

Entry version 185 (11 Dec 2019)
Sequence version 2 (01 Jan 1998)
Previous versions | rss
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Protein

Voltage-gated potassium channel subunit beta-2

Gene

KCNAB2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Cytoplasmic potassium channel subunit that modulates the characteristics of the channel-forming alpha-subunits (PubMed:7649300, PubMed:11825900). Contributes to the regulation of nerve signaling, and prevents neuronal hyperexcitability (By similarity). Promotes expression of the pore-forming alpha subunits at the cell membrane, and thereby increases channel activity (By similarity). Promotes potassium channel closure via a mechanism that does not involve physical obstruction of the channel pore (PubMed:7649300, PubMed:11825900). Promotes KCNA4 channel closure (PubMed:7649300, PubMed:11825900). Modulates the functional properties of KCNA5 (By similarity). Enhances KCNB2 channel activity (By similarity). Binds NADPH and has NADPH-dependent aldoketoreductase activity (By similarity). Has broad substrate specificity and can catalyze the reduction of methylglyoxal, 9,10-phenanthrenequinone, prostaglandin J2, 4-nitrobenzaldehyde, 4-nitroacetophenone and 4-oxo-trans-2-nonenal (in vitro) (By similarity).By similarity2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei63NADP1 Publication1
Binding sitei85NADP1 Publication1
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei90Proton donor/acceptorBy similarity1
Binding sitei90NADP1 Publication1
Binding sitei214NADP1 Publication1
Binding sitei254NADP1 Publication1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi56 – 57NADP1 Publication2
Nucleotide bindingi188 – 189NADP1 Publication2
Nucleotide bindingi243 – 248NADP1 Publication6
Nucleotide bindingi323 – 329NADP1 Publication7

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionIon channel, Oxidoreductase, Voltage-gated channel
Biological processIon transport, Potassium transport, Transport
LigandNADP, Potassium

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-1296072 Voltage gated Potassium channels
R-HSA-6798695 Neutrophil degranulation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Voltage-gated potassium channel subunit beta-2 (EC:1.1.1.-By similarity)
Alternative name(s):
K(+) channel subunit beta-2
Kv-beta-2
Short name:
hKvbeta2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:KCNAB2
Synonyms:KCNA2B, KCNK2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000069424.14

Human Gene Nomenclature Database

More...HGNCi		HGNC:6229 KCNAB2

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		601142 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q13303

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell membrane, Cell projection, Cytoplasm, Cytoskeleton, Membrane, Synapse, Synaptosome

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi90Y → F: No effect on its activity in promoting KCNA4 channel closure. 1 Publication1

Organism-specific databases

DisGeNET

More...DisGeNETi		8514

MalaCards human disease database

More...MalaCardsi		KCNAB2

Open Targets

More...OpenTargetsi		ENSG00000069424

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		1606 1p36 deletion syndrome

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA373

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q13303 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		KCNAB2

Domain mapping of disease mutations (DMDM)

More...DMDMi		18202496

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001487461 – 367Voltage-gated potassium channel subunit beta-2Add BLAST367

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei9PhosphoserineCombined sources1
Modified residuei14PhosphoserineCombined sources1
Modified residuei20PhosphoserineBy similarity1
Modified residuei28Asymmetric dimethylarginine; alternateCombined sources1
Modified residuei28Omega-N-methylarginine; alternateBy similarity1
Modified residuei31Phosphoserine1 Publication1
Modified residuei112Phosphoserine1 Publication1
Modified residuei124N6-acetyllysineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated by PRKCZ; may be regulated by incorporation in a complex composed of PRKCZ and SQSTM1.By similarity

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q13303

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q13303

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q13303

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q13303

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q13303

PeptideAtlas

More...PeptideAtlasi		Q13303

PRoteomics IDEntifications database

More...PRIDEi		Q13303

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		2532
59288 [Q13303-1]
59289 [Q13303-2]
59290 [Q13303-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q13303

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q13303

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Detected in myelinated nerve fibers in the spinal cord, in the juxtaparanodal region of the nodes of Ranvier, but also in the paranodal region (PubMed:11086297). Detected in hippocampus (at protein level) (PubMed:21357749). Detected in hippocampus (PubMed:7649300).3 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000069424 Expressed in 201 organ(s), highest expression level in anterior cingulate cortex

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q13303 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q13303 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		CAB001975

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homotetramer (By similarity). Interaction with tetrameric potassium channel alpha subunits gives rise to a heterooctamer (By similarity). Identified in potassium channel complexes containing KCNA1, KCNA2, KCNA4, KCNA5, KCNA6, KCNAB1 and KCNAB2 (By similarity).

Interacts with KCNA1 (PubMed:11086297).

Interacts with KCNA2 (PubMed:11086297).

Interacts with KCNA4 and KCND3 (By similarity).

Interacts with KCNA5 (By similarity).

Interacts with KCNB2 (By similarity).

Interacts (in unphosphorylated form) with MAPRE1 (By similarity).

Forms a ternary complex with SQSTM1 and PRKCZ (By similarity).

By similarity1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		114086, 38 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		Q13303

Protein interaction database and analysis system

More...IntActi		Q13303, 23 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000367323

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q13303 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1367
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q13303

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		Q13303

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

In contrast to KCNAB1, the shorter N-terminal domain of KCNAB2 cannot mediate closure of delayed rectifier potassium channels by physically obstructing the pore.1 Publication

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the shaker potassium channel beta subunit family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1575 Eukaryota
COG0667 LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00940000157867

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		HOG000250283

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q13303

KEGG Orthology (KO)

More...KOi		K04883

Identification of Orthologs from Complete Genome Data

More...OMAi		PPYSLFW

Database of Orthologous Groups

More...OrthoDBi		1106773at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q13303

TreeFam database of animal gene trees

More...TreeFami		TF324563

Family and domain databases

Conserved Domains Database

More...CDDi		cd06660 Aldo_ket_red, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.20.20.100, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR005983 K_chnl_volt-dep_bsu_KCNAB
IPR005399 K_chnl_volt-dep_bsu_KCNAB-rel
IPR005401 K_chnl_volt-dep_bsu_KCNAB2
IPR023210 NADP_OxRdtase_dom
IPR036812 NADP_OxRdtase_dom_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00248 Aldo_ket_red, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR01579 KCNAB2CHANEL
PR01577 KCNABCHANNEL

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF51430 SSF51430, 1 hit

TIGRFAMs; a protein family database

More...TIGRFAMsi		TIGR01293 Kv_beta, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 5 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 21 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q13303-1) [UniParc]FASTAAdd to basket
Also known as: KvB2.1

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MYPESTTGSP ARLSLRQTGS PGMIYSTRYG SPKRQLQFYR NLGKSGLRVS 
        60         70         80         90        100
CLGLGTWVTF GGQITDEMAE QLMTLAYDNG INLFDTAEVY AAGKAEVVLG 
       110        120        130        140        150
NIIKKKGWRR SSLVITTKIF WGGKAETERG LSRKHIIEGL KASLERLQLE 
       160        170        180        190        200
YVDVVFANRP DPNTPMEETV RAMTHVINQG MAMYWGTSRW SSMEIMEAYS 
       210        220        230        240        250
VARQFNLTPP ICEQAEYHMF QREKVEVQLP ELFHKIGVGA MTWSPLACGI 
       260        270        280        290        300
VSGKYDSGIP PYSRASLKGY QWLKDKILSE EGRRQQAKLK ELQAIAERLG 
       310        320        330        340        350
CTLPQLAIAW CLRNEGVSSV LLGASNADQL MENIGAIQVL PKLSSSIIHE 
       360 
IDSILGNKPY SKKDYRS
Length:367
Mass (Da):41,000
Last modified:January 1, 1998 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i91A673F8992140DA
GO
Isoform 2 (identifier: Q13303-2) [UniParc]FASTAAdd to basket
Also known as: KvB2.2

The sequence of this isoform differs from the canonical sequence as follows:
     26-39: Missing.

Show »
Length:353
Mass (Da):39,287
Checksum:i7D59C8203AC5606F
GO
Isoform 3 (identifier: Q13303-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-38: MYPESTTGSP...YGSPKRQLQF → MLSMTYSESL...GCTAQRTGMK
     167-167: E → EGDPFSSSKSRTFIIE

Show »
Length:415
Mass (Da):46,527
Checksum:i3AD46E32E4B200AF
GO
Isoform 4 (identifier: Q13303-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-67: Missing.

Show »
Length:300
Mass (Da):33,657
Checksum:i3ADDAAE15216B737
GO
Isoform 5 (identifier: Q13303-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     340-367: LPKLSSSIIHEIDSILGNKPYSKKDYRS → RVRGPAGQRA...GELAFQQEQT

Show »
Length:395
Mass (Da):43,560
Checksum:i4E6CED2B3028BBB0
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 21 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5TG81Q5TG81_HUMAN
Voltage-gated potassium channel sub...
KCNAB2
152Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EKU4K7EKU4_HUMAN
Voltage-gated potassium channel sub...
KCNAB2
197Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5TG84Q5TG84_HUMAN
Voltage-gated potassium channel sub...
KCNAB2
157Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A590UK89A0A590UK89_HUMAN
Voltage-gated potassium channel sub...
KCNAB2
146Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5TG78Q5TG78_HUMAN
Voltage-gated potassium channel sub...
KCNAB2
139Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A590UJI8A0A590UJI8_HUMAN
Voltage-gated potassium channel sub...
KCNAB2
67Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A590UJK5A0A590UJK5_HUMAN
Voltage-gated potassium channel sub...
KCNAB2
62Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EIR5K7EIR5_HUMAN
Voltage-gated potassium channel sub...
KCNAB2
178Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A590UJB6A0A590UJB6_HUMAN
Voltage-gated potassium channel sub...
KCNAB2
398Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A590UJU4A0A590UJU4_HUMAN
Voltage-gated potassium channel sub...
KCNAB2
160Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0443111 – 67Missing in isoform 4. 1 PublicationAdd BLAST67
Alternative sequenceiVSP_0411891 – 38MYPES…RQLQF → MLSMTYSESLRSVSSRCHSE WALHPVRQTDTLELQRLREV RAAAQARNMESFLRMHGLSL DGCTAQRTGMK in isoform 3. 1 PublicationAdd BLAST38
Alternative sequenceiVSP_00105426 – 39Missing in isoform 2. 1 PublicationAdd BLAST14
Alternative sequenceiVSP_041190167E → EGDPFSSSKSRTFIIE in isoform 3. 1 Publication1
Alternative sequenceiVSP_057282340 – 367LPKLS…KDYRS → RVRGPAGQRAHPSPSPVQCI LPGSSCVPGSVLGTQDAPVN HQSCAPGELAFQQEQT in isoform 5. 1 PublicationAdd BLAST28

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
U33429 mRNA Translation: AAC50955.1
AF029749 mRNA Translation: AAB84170.1
AF044253 mRNA Translation: AAB99859.1
AK124696 mRNA Translation: BAG54071.1
AK131252 mRNA Translation: BAD18431.1
AK289819 mRNA Translation: BAF82508.1
AK315858 mRNA Translation: BAF98749.1
AL035406 Genomic DNA No translation available.
BC110351 mRNA Translation: AAI10352.1
BC126424 mRNA Translation: AAI26425.1
BC130413 mRNA Translation: AAI30414.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS55.1 [Q13303-1]
CCDS55570.1 [Q13303-3]
CCDS55571.1 [Q13303-4]
CCDS56.1 [Q13303-2]

Protein sequence database of the Protein Information Resource

More...PIRi		S66502

NCBI Reference Sequences

More...RefSeqi		NP_001186789.1, NM_001199860.1 [Q13303-1]
NP_001186790.1, NM_001199861.1 [Q13303-1]
NP_001186791.1, NM_001199862.1 [Q13303-3]
NP_001186792.1, NM_001199863.1 [Q13303-4]
NP_003627.1, NM_003636.3 [Q13303-1]
NP_742128.1, NM_172130.2 [Q13303-2]
XP_005263571.1, XM_005263514.2 [Q13303-2]
XP_011540623.1, XM_011542321.2 [Q13303-5]
XP_011540624.1, XM_011542322.2 [Q13303-5]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000164247; ENSP00000164247; ENSG00000069424 [Q13303-1]
ENST00000352527; ENSP00000318772; ENSG00000069424 [Q13303-2]
ENST00000378083; ENSP00000367323; ENSG00000069424 [Q13303-3]
ENST00000378092; ENSP00000367332; ENSG00000069424 [Q13303-1]
ENST00000378097; ENSP00000367337; ENSG00000069424 [Q13303-1]
ENST00000428161; ENSP00000400285; ENSG00000069424 [Q13303-1]
ENST00000458166; ENSP00000396167; ENSG00000069424 [Q13303-4]
ENST00000602612; ENSP00000473602; ENSG00000069424 [Q13303-5]
ENST00000666163; ENSP00000499370; ENSG00000069424 [Q13303-2]
ENST00000668559; ENSP00000499361; ENSG00000069424 [Q13303-5]
ENST00000669250; ENSP00000499485; ENSG00000069424 [Q13303-2]
ENST00000671676; ENSP00000499496; ENSG00000069424 [Q13303-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		8514

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:8514

UCSC genome browser

More...UCSCi		uc001alv.3 human [Q13303-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U33429 mRNA Translation: AAC50955.1
AF029749 mRNA Translation: AAB84170.1
AF044253 mRNA Translation: AAB99859.1
AK124696 mRNA Translation: BAG54071.1
AK131252 mRNA Translation: BAD18431.1
AK289819 mRNA Translation: BAF82508.1
AK315858 mRNA Translation: BAF98749.1
AL035406 Genomic DNA No translation available.
BC110351 mRNA Translation: AAI10352.1
BC126424 mRNA Translation: AAI26425.1
BC130413 mRNA Translation: AAI30414.1
CCDSiCCDS55.1 [Q13303-1]
CCDS55570.1 [Q13303-3]
CCDS55571.1 [Q13303-4]
CCDS56.1 [Q13303-2]
PIRiS66502
RefSeqiNP_001186789.1, NM_001199860.1 [Q13303-1]
NP_001186790.1, NM_001199861.1 [Q13303-1]
NP_001186791.1, NM_001199862.1 [Q13303-3]
NP_001186792.1, NM_001199863.1 [Q13303-4]
NP_003627.1, NM_003636.3 [Q13303-1]
NP_742128.1, NM_172130.2 [Q13303-2]
XP_005263571.1, XM_005263514.2 [Q13303-2]
XP_011540623.1, XM_011542321.2 [Q13303-5]
XP_011540624.1, XM_011542322.2 [Q13303-5]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1ZSXX-ray1.90A39-360[»]
SMRiQ13303
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi114086, 38 interactors
CORUMiQ13303
IntActiQ13303, 23 interactors
STRINGi9606.ENSP00000367323

PTM databases

iPTMnetiQ13303
PhosphoSitePlusiQ13303

Polymorphism and mutation databases

BioMutaiKCNAB2
DMDMi18202496

Proteomic databases

EPDiQ13303
jPOSTiQ13303
MassIVEiQ13303
MaxQBiQ13303
PaxDbiQ13303
PeptideAtlasiQ13303
PRIDEiQ13303
ProteomicsDBi2532
59288 [Q13303-1]
59289 [Q13303-2]
59290 [Q13303-3]

Protocols and materials databases

The DNASU plasmid repository

More...DNASUi		8514

Genome annotation databases

EnsembliENST00000164247; ENSP00000164247; ENSG00000069424 [Q13303-1]
ENST00000352527; ENSP00000318772; ENSG00000069424 [Q13303-2]
ENST00000378083; ENSP00000367323; ENSG00000069424 [Q13303-3]
ENST00000378092; ENSP00000367332; ENSG00000069424 [Q13303-1]
ENST00000378097; ENSP00000367337; ENSG00000069424 [Q13303-1]
ENST00000428161; ENSP00000400285; ENSG00000069424 [Q13303-1]
ENST00000458166; ENSP00000396167; ENSG00000069424 [Q13303-4]
ENST00000602612; ENSP00000473602; ENSG00000069424 [Q13303-5]
ENST00000666163; ENSP00000499370; ENSG00000069424 [Q13303-2]
ENST00000668559; ENSP00000499361; ENSG00000069424 [Q13303-5]
ENST00000669250; ENSP00000499485; ENSG00000069424 [Q13303-2]
ENST00000671676; ENSP00000499496; ENSG00000069424 [Q13303-1]
GeneIDi8514
KEGGihsa:8514
UCSCiuc001alv.3 human [Q13303-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		8514
DisGeNETi8514
EuPathDBiHostDB:ENSG00000069424.14

GeneCards: human genes, protein and diseases

More...GeneCardsi		KCNAB2
HGNCiHGNC:6229 KCNAB2
HPAiCAB001975
MalaCardsiKCNAB2
MIMi601142 gene
neXtProtiNX_Q13303
OpenTargetsiENSG00000069424
Orphaneti1606 1p36 deletion syndrome
PharmGKBiPA373

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1575 Eukaryota
COG0667 LUCA
GeneTreeiENSGT00940000157867
HOGENOMiHOG000250283
InParanoidiQ13303
KOiK04883
OMAiPPYSLFW
OrthoDBi1106773at2759
PhylomeDBiQ13303
TreeFamiTF324563

Enzyme and pathway databases

ReactomeiR-HSA-1296072 Voltage gated Potassium channels
R-HSA-6798695 Neutrophil degranulation

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		KCNAB2 human
EvolutionaryTraceiQ13303

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		KCNAB2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		8514
PharosiQ13303 Tbio

Protein Ontology

More...PROi		PR:Q13303
RNActiQ13303 protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000069424 Expressed in 201 organ(s), highest expression level in anterior cingulate cortex
ExpressionAtlasiQ13303 baseline and differential
GenevisibleiQ13303 HS

Family and domain databases

CDDicd06660 Aldo_ket_red, 1 hit
Gene3Di3.20.20.100, 1 hit
InterProiView protein in InterPro
IPR005983 K_chnl_volt-dep_bsu_KCNAB
IPR005399 K_chnl_volt-dep_bsu_KCNAB-rel
IPR005401 K_chnl_volt-dep_bsu_KCNAB2
IPR023210 NADP_OxRdtase_dom
IPR036812 NADP_OxRdtase_dom_sf
PfamiView protein in Pfam
PF00248 Aldo_ket_red, 1 hit
PRINTSiPR01579 KCNAB2CHANEL
PR01577 KCNABCHANNEL
SUPFAMiSSF51430 SSF51430, 1 hit
TIGRFAMsiTIGR01293 Kv_beta, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiKCAB2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q13303
Secondary accession number(s): A0AVM9
, A8K1A4, B0AZR7, O43659, Q2YD85, Q5TG82, Q5TG83, Q6ZNE4, Q99411
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 18, 2001
Last sequence update: January 1, 1998
Last modified: December 11, 2019
This is version 185 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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