UniProtKB - Q13303 (KCAB2_HUMAN)
Voltage-gated potassium channel subunit beta-2
KCNAB2
Functioni
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 63 | NADP1 Publication | 1 | |
Binding sitei | 85 | NADP1 Publication | 1 | |
Active sitei | 90 | Proton donor/acceptorBy similarity | 1 | |
Binding sitei | 90 | NADP1 Publication | 1 | |
Binding sitei | 214 | NADP1 Publication | 1 | |
Binding sitei | 254 | NADP1 Publication | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 56 – 57 | NADP1 Publication | 2 | |
Nucleotide bindingi | 188 – 189 | NADP1 Publication | 2 | |
Nucleotide bindingi | 243 – 248 | NADP1 Publication | 6 | |
Nucleotide bindingi | 323 – 329 | NADP1 Publication | 7 |
GO - Molecular functioni
- aldo-keto reductase (NADP) activity Source: UniProtKB
- ion channel binding Source: GO_Central
- potassium channel regulator activity Source: UniProtKB
- voltage-gated potassium channel activity Source: InterPro
GO - Biological processi
- hematopoietic progenitor cell differentiation Source: Ensembl
- NADPH oxidation Source: UniProtKB
- neuromuscular process Source: Ensembl
- neutrophil degranulation Source: Reactome
- oxidation-reduction process Source: UniProtKB
- regulation of action potential Source: GO_Central
- regulation of potassium ion transmembrane transport Source: UniProtKB
- regulation of protein localization to cell surface Source: UniProtKB
Keywordsi
Molecular function | Ion channel, Oxidoreductase, Voltage-gated channel |
Biological process | Ion transport, Potassium transport, Transport |
Ligand | NADP, Potassium |
Enzyme and pathway databases
PathwayCommonsi | Q13303 |
Reactomei | R-HSA-1296072, Voltage gated Potassium channels R-HSA-6798695, Neutrophil degranulation |
Names & Taxonomyi
Protein namesi | Recommended name: Voltage-gated potassium channel subunit beta-2 (EC:1.1.1.-By similarity)Alternative name(s): K(+) channel subunit beta-2 Kv-beta-2 Short name: hKvbeta2 |
Gene namesi | Name:KCNAB2 Synonyms:KCNA2B, KCNK2 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000069424.14 |
HGNCi | HGNC:6229, KCNAB2 |
MIMi | 601142, gene |
neXtProti | NX_Q13303 |
Subcellular locationi
Plasma membrane
- Cell membrane By similarity; Peripheral membrane protein Curated; Cytoplasmic side Curated
Cytoskeleton
- cytoskeleton By similarity
Other locations
- Cytoplasm By similarity
- Membrane 2 Publications; Peripheral membrane protein Curated; Cytoplasmic side Curated
- axon 1 Publication
- synaptosome 1 Publication
Note: Recruited to the cytoplasmic side of the cell membrane via its interaction with pore-forming potassium channel alpha subunits. Associates with microtubules when unphosphorylated.By similarity
Cytoskeleton
- cytoskeleton Source: UniProtKB-SubCell
Cytosol
- cytosol Source: UniProtKB
Plasma Membrane
- extrinsic component of cytoplasmic side of plasma membrane Source: UniProtKB
- plasma membrane Source: Reactome
- voltage-gated potassium channel complex Source: UniProtKB
Other locations
- axon terminus Source: Ensembl
- juxtaparanode region of axon Source: UniProtKB
- membrane Source: UniProtKB
- pinceau fiber Source: UniProtKB
- postsynaptic density Source: Ensembl
- specific granule membrane Source: Reactome
- tertiary granule membrane Source: Reactome
Keywords - Cellular componenti
Cell junction, Cell membrane, Cell projection, Cytoplasm, Cytoskeleton, Membrane, Synapse, SynaptosomePathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 90 | Y → F: No effect on its activity in promoting KCNA4 channel closure. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 8514 |
MalaCardsi | KCNAB2 |
OpenTargetsi | ENSG00000069424 |
Orphaneti | 1606, 1p36 deletion syndrome |
PharmGKBi | PA373 |
Miscellaneous databases
Pharosi | Q13303, Tbio |
Chemistry databases
DrugBanki | DB00228, Enflurane DB01110, Miconazole DB01069, Promethazine |
Polymorphism and mutation databases
BioMutai | KCNAB2 |
DMDMi | 18202496 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000148746 | 1 – 367 | Voltage-gated potassium channel subunit beta-2Add BLAST | 367 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 9 | PhosphoserineCombined sources | 1 | |
Modified residuei | 14 | PhosphoserineCombined sources | 1 | |
Modified residuei | 20 | PhosphoserineBy similarity | 1 | |
Modified residuei | 28 | Asymmetric dimethylarginine; alternateCombined sources | 1 | |
Modified residuei | 28 | Omega-N-methylarginine; alternateBy similarity | 1 | |
Modified residuei | 31 | Phosphoserine1 Publication | 1 | |
Modified residuei | 112 | Phosphoserine1 Publication | 1 | |
Modified residuei | 124 | N6-acetyllysineCombined sources | 1 |
Post-translational modificationi
Keywords - PTMi
Acetylation, Methylation, PhosphoproteinProteomic databases
EPDi | Q13303 |
jPOSTi | Q13303 |
MassIVEi | Q13303 |
MaxQBi | Q13303 |
PaxDbi | Q13303 |
PeptideAtlasi | Q13303 |
PRIDEi | Q13303 |
ProteomicsDBi | 2532 59288 [Q13303-1] 59289 [Q13303-2] 59290 [Q13303-3] |
PTM databases
iPTMneti | Q13303 |
PhosphoSitePlusi | Q13303 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000069424, Expressed in anterior cingulate cortex and 216 other tissues |
ExpressionAtlasi | Q13303, baseline and differential |
Genevisiblei | Q13303, HS |
Organism-specific databases
HPAi | ENSG00000069424, Tissue enhanced (bone marrow, brain) |
Interactioni
Subunit structurei
Homotetramer (By similarity). Interaction with tetrameric potassium channel alpha subunits gives rise to a heterooctamer (By similarity). Identified in potassium channel complexes containing KCNA1, KCNA2, KCNA4, KCNA5, KCNA6, KCNAB1 and KCNAB2 (By similarity).
Interacts with KCNA1 (PubMed:11086297).
Interacts with KCNA2 (PubMed:11086297).
Interacts with KCNA4 and KCND3 (By similarity).
Interacts with KCNA5 (By similarity).
Interacts with KCNB2 (By similarity).
Interacts (in unphosphorylated form) with MAPRE1 (By similarity).
Forms a ternary complex with SQSTM1 and PRKCZ (By similarity).
By similarity1 PublicationGO - Molecular functioni
- ion channel binding Source: GO_Central
Protein-protein interaction databases
BioGRIDi | 114086, 38 interactors |
CORUMi | Q13303 |
IntActi | Q13303, 23 interactors |
STRINGi | 9606.ENSP00000367323 |
Miscellaneous databases
RNActi | Q13303, protein |
Structurei
Secondary structure
3D structure databases
SMRi | Q13303 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q13303 |
Family & Domainsi
Domaini
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG1575, Eukaryota |
GeneTreei | ENSGT00940000157867 |
InParanoidi | Q13303 |
OMAi | VDLWQVH |
OrthoDBi | 633642at2759 |
PhylomeDBi | Q13303 |
TreeFami | TF324563 |
Family and domain databases
CDDi | cd06660, Aldo_ket_red, 1 hit |
Gene3Di | 3.20.20.100, 1 hit |
InterProi | View protein in InterPro IPR005983, K_chnl_volt-dep_bsu_KCNAB IPR005399, K_chnl_volt-dep_bsu_KCNAB-rel IPR005401, K_chnl_volt-dep_bsu_KCNAB2 IPR023210, NADP_OxRdtase_dom IPR036812, NADP_OxRdtase_dom_sf |
Pfami | View protein in Pfam PF00248, Aldo_ket_red, 1 hit |
PRINTSi | PR01579, KCNAB2CHANEL PR01577, KCNABCHANNEL |
SUPFAMi | SSF51430, SSF51430, 1 hit |
TIGRFAMsi | TIGR01293, Kv_beta, 1 hit |
s (5+)i Sequence
Sequence statusi: Complete.
This entry describes 5 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 5 described isoforms and 21 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MYPESTTGSP ARLSLRQTGS PGMIYSTRYG SPKRQLQFYR NLGKSGLRVS
60 70 80 90 100
CLGLGTWVTF GGQITDEMAE QLMTLAYDNG INLFDTAEVY AAGKAEVVLG
110 120 130 140 150
NIIKKKGWRR SSLVITTKIF WGGKAETERG LSRKHIIEGL KASLERLQLE
160 170 180 190 200
YVDVVFANRP DPNTPMEETV RAMTHVINQG MAMYWGTSRW SSMEIMEAYS
210 220 230 240 250
VARQFNLTPP ICEQAEYHMF QREKVEVQLP ELFHKIGVGA MTWSPLACGI
260 270 280 290 300
VSGKYDSGIP PYSRASLKGY QWLKDKILSE EGRRQQAKLK ELQAIAERLG
310 320 330 340 350
CTLPQLAIAW CLRNEGVSSV LLGASNADQL MENIGAIQVL PKLSSSIIHE
360
IDSILGNKPY SKKDYRS
Computationally mapped potential isoform sequencesi
There are 21 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A590UJB6 | A0A590UJB6_HUMAN | K(+) channel subunit beta-2 | KCNAB2 | 398 | Annotation score: | ||
A0A590UJJ4 | A0A590UJJ4_HUMAN | K(+) channel subunit beta-2 | KCNAB2 | 328 | Annotation score: | ||
A0A5F9UN28 | A0A5F9UN28_HUMAN | K(+) channel subunit beta-2 | KCNAB2 | 382 | Annotation score: | ||
K7EKU4 | K7EKU4_HUMAN | Voltage-gated potassium channel sub... | KCNAB2 | 197 | Annotation score: | ||
A0A590UK89 | A0A590UK89_HUMAN | Voltage-gated potassium channel sub... | KCNAB2 | 146 | Annotation score: | ||
K7EIR5 | K7EIR5_HUMAN | Voltage-gated potassium channel sub... | KCNAB2 | 178 | Annotation score: | ||
A0A590UJU4 | A0A590UJU4_HUMAN | Voltage-gated potassium channel sub... | KCNAB2 | 160 | Annotation score: | ||
Q5TG81 | Q5TG81_HUMAN | Voltage-gated potassium channel sub... | KCNAB2 | 152 | Annotation score: | ||
Q5TG84 | Q5TG84_HUMAN | Voltage-gated potassium channel sub... | KCNAB2 | 157 | Annotation score: | ||
Q5TG78 | Q5TG78_HUMAN | Voltage-gated potassium channel sub... | KCNAB2 | 139 | Annotation score: | ||
There are more potential isoformsShow all |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_044311 | 1 – 67 | Missing in isoform 4. 1 PublicationAdd BLAST | 67 | |
Alternative sequenceiVSP_041189 | 1 – 38 | MYPES…RQLQF → MLSMTYSESLRSVSSRCHSE WALHPVRQTDTLELQRLREV RAAAQARNMESFLRMHGLSL DGCTAQRTGMK in isoform 3. 1 PublicationAdd BLAST | 38 | |
Alternative sequenceiVSP_001054 | 26 – 39 | Missing in isoform 2. 1 PublicationAdd BLAST | 14 | |
Alternative sequenceiVSP_041190 | 167 | E → EGDPFSSSKSRTFIIE in isoform 3. 1 Publication | 1 | |
Alternative sequenceiVSP_057282 | 340 – 367 | LPKLS…KDYRS → RVRGPAGQRAHPSPSPVQCI LPGSSCVPGSVLGTQDAPVN HQSCAPGELAFQQEQT in isoform 5. 1 PublicationAdd BLAST | 28 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U33429 mRNA Translation: AAC50955.1 AF029749 mRNA Translation: AAB84170.1 AF044253 mRNA Translation: AAB99859.1 AK124696 mRNA Translation: BAG54071.1 AK131252 mRNA Translation: BAD18431.1 AK289819 mRNA Translation: BAF82508.1 AK315858 mRNA Translation: BAF98749.1 AL035406 Genomic DNA No translation available. BC110351 mRNA Translation: AAI10352.1 BC126424 mRNA Translation: AAI26425.1 BC130413 mRNA Translation: AAI30414.1 |
CCDSi | CCDS55.1 [Q13303-1] CCDS55570.1 [Q13303-3] CCDS55571.1 [Q13303-4] CCDS56.1 [Q13303-2] |
PIRi | S66502 |
RefSeqi | NP_001186789.1, NM_001199860.1 [Q13303-1] NP_001186790.1, NM_001199861.1 [Q13303-1] NP_001186791.1, NM_001199862.1 [Q13303-3] NP_001186792.1, NM_001199863.1 [Q13303-4] NP_003627.1, NM_003636.3 [Q13303-1] NP_742128.1, NM_172130.2 [Q13303-2] XP_005263571.1, XM_005263514.2 [Q13303-2] XP_011540623.1, XM_011542321.2 [Q13303-5] XP_011540624.1, XM_011542322.2 [Q13303-5] |
Genome annotation databases
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U33429 mRNA Translation: AAC50955.1 AF029749 mRNA Translation: AAB84170.1 AF044253 mRNA Translation: AAB99859.1 AK124696 mRNA Translation: BAG54071.1 AK131252 mRNA Translation: BAD18431.1 AK289819 mRNA Translation: BAF82508.1 AK315858 mRNA Translation: BAF98749.1 AL035406 Genomic DNA No translation available. BC110351 mRNA Translation: AAI10352.1 BC126424 mRNA Translation: AAI26425.1 BC130413 mRNA Translation: AAI30414.1 |
CCDSi | CCDS55.1 [Q13303-1] CCDS55570.1 [Q13303-3] CCDS55571.1 [Q13303-4] CCDS56.1 [Q13303-2] |
PIRi | S66502 |
RefSeqi | NP_001186789.1, NM_001199860.1 [Q13303-1] NP_001186790.1, NM_001199861.1 [Q13303-1] NP_001186791.1, NM_001199862.1 [Q13303-3] NP_001186792.1, NM_001199863.1 [Q13303-4] NP_003627.1, NM_003636.3 [Q13303-1] NP_742128.1, NM_172130.2 [Q13303-2] XP_005263571.1, XM_005263514.2 [Q13303-2] XP_011540623.1, XM_011542321.2 [Q13303-5] XP_011540624.1, XM_011542322.2 [Q13303-5] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1ZSX | X-ray | 1.90 | A | 39-360 | [»] | |
SMRi | Q13303 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 114086, 38 interactors |
CORUMi | Q13303 |
IntActi | Q13303, 23 interactors |
STRINGi | 9606.ENSP00000367323 |
Chemistry databases
DrugBanki | DB00228, Enflurane DB01110, Miconazole DB01069, Promethazine |
PTM databases
iPTMneti | Q13303 |
PhosphoSitePlusi | Q13303 |
Polymorphism and mutation databases
BioMutai | KCNAB2 |
DMDMi | 18202496 |
Proteomic databases
EPDi | Q13303 |
jPOSTi | Q13303 |
MassIVEi | Q13303 |
MaxQBi | Q13303 |
PaxDbi | Q13303 |
PeptideAtlasi | Q13303 |
PRIDEi | Q13303 |
ProteomicsDBi | 2532 59288 [Q13303-1] 59289 [Q13303-2] 59290 [Q13303-3] |
Protocols and materials databases
ABCDi | Q13303, 3 sequenced antibodies |
Antibodypediai | 4538, 159 antibodies |
DNASUi | 8514 |
Genome annotation databases
Organism-specific databases
CTDi | 8514 |
DisGeNETi | 8514 |
EuPathDBi | HostDB:ENSG00000069424.14 |
GeneCardsi | KCNAB2 |
HGNCi | HGNC:6229, KCNAB2 |
HPAi | ENSG00000069424, Tissue enhanced (bone marrow, brain) |
MalaCardsi | KCNAB2 |
MIMi | 601142, gene |
neXtProti | NX_Q13303 |
OpenTargetsi | ENSG00000069424 |
Orphaneti | 1606, 1p36 deletion syndrome |
PharmGKBi | PA373 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1575, Eukaryota |
GeneTreei | ENSGT00940000157867 |
InParanoidi | Q13303 |
OMAi | VDLWQVH |
OrthoDBi | 633642at2759 |
PhylomeDBi | Q13303 |
TreeFami | TF324563 |
Enzyme and pathway databases
PathwayCommonsi | Q13303 |
Reactomei | R-HSA-1296072, Voltage gated Potassium channels R-HSA-6798695, Neutrophil degranulation |
Miscellaneous databases
BioGRID-ORCSi | 8514, 1 hit in 845 CRISPR screens |
ChiTaRSi | KCNAB2, human |
EvolutionaryTracei | Q13303 |
GeneWikii | KCNAB2 |
GenomeRNAii | 8514 |
Pharosi | Q13303, Tbio |
PROi | PR:Q13303 |
RNActi | Q13303, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000069424, Expressed in anterior cingulate cortex and 216 other tissues |
ExpressionAtlasi | Q13303, baseline and differential |
Genevisiblei | Q13303, HS |
Family and domain databases
CDDi | cd06660, Aldo_ket_red, 1 hit |
Gene3Di | 3.20.20.100, 1 hit |
InterProi | View protein in InterPro IPR005983, K_chnl_volt-dep_bsu_KCNAB IPR005399, K_chnl_volt-dep_bsu_KCNAB-rel IPR005401, K_chnl_volt-dep_bsu_KCNAB2 IPR023210, NADP_OxRdtase_dom IPR036812, NADP_OxRdtase_dom_sf |
Pfami | View protein in Pfam PF00248, Aldo_ket_red, 1 hit |
PRINTSi | PR01579, KCNAB2CHANEL PR01577, KCNABCHANNEL |
SUPFAMi | SSF51430, SSF51430, 1 hit |
TIGRFAMsi | TIGR01293, Kv_beta, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | KCAB2_HUMAN | |
Accessioni | Q13303Primary (citable) accession number: Q13303 Secondary accession number(s): A0AVM9 Q99411 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 18, 2001 |
Last sequence update: | January 1, 1998 | |
Last modified: | December 2, 2020 | |
This is version 190 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM