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Protein

Mammaglobin-A

Gene

SCGB2A2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Mammaglobin-A
Alternative name(s):
Mammaglobin-1
Secretoglobin family 2A member 2
Gene namesi
Name:SCGB2A2
Synonyms:MGB1, UGB2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000110484.6
HGNCiHGNC:7050 SCGB2A2
MIMi605562 gene
neXtProtiNX_Q13296

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi4250
OpenTargetsiENSG00000110484
PharmGKBiPA34993

Polymorphism and mutation databases

DMDMi2833243

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
ChainiPRO_000003637219 – 93Mammaglobin-AAdd BLAST75

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi53N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi68N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ13296
PeptideAtlasiQ13296
PRIDEiQ13296
ProteomicsDBi59286
59287 [Q13296-2]

PTM databases

GlyConnecti1486
iPTMnetiQ13296
PhosphoSitePlusiQ13296

Expressioni

Tissue specificityi

Mammary gland specific. Over-expressed in breast cancer.

Gene expression databases

BgeeiENSG00000110484 Expressed in 91 organ(s), highest expression level in epithelium of mammary gland
CleanExiHS_SCGB2A2
ExpressionAtlasiQ13296 baseline and differential
GenevisibleiQ13296 HS

Organism-specific databases

HPAiCAB026270

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
VASPP505523EBI-9058786,EBI-748201

Protein-protein interaction databases

BioGridi110406, 82 interactors
IntActiQ13296, 4 interactors
MINTiQ13296
STRINGi9606.ENSP00000227918

Structurei

3D structure databases

ProteinModelPortaliQ13296
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410JEU0 Eukaryota
ENOG4111A32 LUCA
GeneTreeiENSGT00390000013802
HOGENOMiHOG000294150
HOVERGENiHBG005021
InParanoidiQ13296
OMAiQLIYDSS
PhylomeDBiQ13296
TreeFamiTF338521

Family and domain databases

CDDicd00633 Secretoglobin, 1 hit
InterProiView protein in InterPro
IPR016126 Secretoglobin
IPR035960 Secretoglobin_sf
PfamiView protein in Pfam
PF01099 Uteroglobin, 1 hit
SUPFAMiSSF48201 SSF48201, 1 hit
PROSITEiView protein in PROSITE
PS51311 SCGB, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q13296-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKLLMVLMLA ALSQHCYAGS GCPLLENVIS KTINPQVSKT EYKELLQEFI
60 70 80 90
DDNATTNAID ELKECFLNQT DETLSNVEVF MQLIYDSSLC DLF
Length:93
Mass (Da):10,499
Last modified:November 1, 1996 - v1
Checksum:i2896E8C43BF053E2
GO
Isoform 2 (identifier: Q13296-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     79-81: Missing.

Show »
Length:90
Mass (Da):10,122
Checksum:iD166F3FC34FE990D
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q6NX70Q6NX70_HUMAN
Mammaglobin-A
SCGB2A2
120Annotation score:

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_00912279 – 81Missing in isoform 2. 1 Publication3

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U33147 mRNA Translation: AAC50375.1
AF015224 Genomic DNA Translation: AAC39608.1
AY217100 mRNA Translation: AAO60111.1
BC128252 mRNA Translation: AAI28253.1
BC128402 mRNA Translation: AAI28403.1
CCDSiCCDS8018.1 [Q13296-1]
RefSeqiNP_002402.1, NM_002411.3 [Q13296-1]
UniGeneiHs.46452

Genome annotation databases

EnsembliENST00000227918; ENSP00000227918; ENSG00000110484 [Q13296-1]
GeneIDi4250
KEGGihsa:4250
UCSCiuc001ntc.5 human [Q13296-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U33147 mRNA Translation: AAC50375.1
AF015224 Genomic DNA Translation: AAC39608.1
AY217100 mRNA Translation: AAO60111.1
BC128252 mRNA Translation: AAI28253.1
BC128402 mRNA Translation: AAI28403.1
CCDSiCCDS8018.1 [Q13296-1]
RefSeqiNP_002402.1, NM_002411.3 [Q13296-1]
UniGeneiHs.46452

3D structure databases

ProteinModelPortaliQ13296
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110406, 82 interactors
IntActiQ13296, 4 interactors
MINTiQ13296
STRINGi9606.ENSP00000227918

PTM databases

GlyConnecti1486
iPTMnetiQ13296
PhosphoSitePlusiQ13296

Polymorphism and mutation databases

DMDMi2833243

Proteomic databases

PaxDbiQ13296
PeptideAtlasiQ13296
PRIDEiQ13296
ProteomicsDBi59286
59287 [Q13296-2]

Protocols and materials databases

DNASUi4250
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000227918; ENSP00000227918; ENSG00000110484 [Q13296-1]
GeneIDi4250
KEGGihsa:4250
UCSCiuc001ntc.5 human [Q13296-1]

Organism-specific databases

CTDi4250
DisGeNETi4250
EuPathDBiHostDB:ENSG00000110484.6
GeneCardsiSCGB2A2
HGNCiHGNC:7050 SCGB2A2
HPAiCAB026270
MIMi605562 gene
neXtProtiNX_Q13296
OpenTargetsiENSG00000110484
PharmGKBiPA34993
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410JEU0 Eukaryota
ENOG4111A32 LUCA
GeneTreeiENSGT00390000013802
HOGENOMiHOG000294150
HOVERGENiHBG005021
InParanoidiQ13296
OMAiQLIYDSS
PhylomeDBiQ13296
TreeFamiTF338521

Miscellaneous databases

ChiTaRSiSCGB2A2 human
GeneWikiiMammaglobin-A
GenomeRNAii4250
PROiPR:Q13296
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000110484 Expressed in 91 organ(s), highest expression level in epithelium of mammary gland
CleanExiHS_SCGB2A2
ExpressionAtlasiQ13296 baseline and differential
GenevisibleiQ13296 HS

Family and domain databases

CDDicd00633 Secretoglobin, 1 hit
InterProiView protein in InterPro
IPR016126 Secretoglobin
IPR035960 Secretoglobin_sf
PfamiView protein in Pfam
PF01099 Uteroglobin, 1 hit
SUPFAMiSSF48201 SSF48201, 1 hit
PROSITEiView protein in PROSITE
PS51311 SCGB, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSG2A2_HUMAN
AccessioniPrimary (citable) accession number: Q13296
Secondary accession number(s): A1A522, Q86WH8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: October 10, 2018
This is version 134 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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